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Zhao Lianggong L The Second Clinical Medical College of Lanzhou University, 82 Cuiying Men, Lanzhou 730030, PR China; Orthopaedics Key Laboratory of Gansu Province, Lanzhou 730000, PR - - 2014
Radix Hedysari polysaccharides (HPS) is the principal active fraction of Radix Hedysari (RH). The information about HPS3d, the main fraction of HPS3, and its effect on bone is still unknown. In the present study, the purified HPS3d was obtained by anion-exchange column. It consisted of 94.38% polysaccharide, 3.40% protein and ...
Lei San-Lin SL Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. - - 2014
MicroRNAs (miRs) function as key regulators of gene expression and their deregulation is associated with the carcinogenesis of various cancers. In the present study, the aim was to validate the potential roles and regulatory mechanisms of miR-708 and miR-31 in colorectal cancer (CRC) cells. miR-708 and miR-31 were found to ...
Weaver Ian C G IC Department of Psychology and Neuroscience, Dalhousie University, Life Science Research Institute, 1348 Summer Street, Halifax, Nova Scotia, Canada B3H - - 2014
Variations in maternal care in the rat influence the epigenetic state and transcriptional activity of glucocorticoid receptor (GR) gene in the hippocampus. The mechanisms underlying this maternal effect remained to be defined, including the nature of the relevant maternally regulated intracellular signalling pathways. We show here that increased maternal licking/grooming ...
Dong Jun J The Orthopedics Department, The Second Affiliated Hospital of Xi'an Jiaotong University, no. 157, West Five Road, Xi'an, 710004, - - 2014
Spinal cord injury (SCI) is medically and socioeconomically debilitating, and effective treatments are lacking. The elucidation of the pathophysiological mechanisms underlying SCI is essential for developing effective treatments for SCI. MicroRNAs (miRNAs) are small non-coding RNA molecules (18-24 nucleotides long) that regulate gene expression by interacting with specific target sequences. ...
Yu Ning N Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai 200050, - - 2014
IL-1β is now emerging as a critical cytokine in the pathogenesis of Th17-mediated skin diseases, including psoriasis. Psoriatic keratinocytes are a major source of IL-1β, however, the mechanisms triggering IL-1β processing remain unknown. Recently, an acute-phase protein serum amyloid A (SAA) has been identified as a danger signal that triggers ...
Campos-Melo Danae D Molecular Medicine Group, Robarts Research Institute, Western University, London, ON, - - 2014
For many years, epidemiological studies have suggested an association between cancer and neurodegenerative disorders-two disease processes that seemingly have little in common. Although these two disease processes share disruptions in a wide range of cellular pathways, including cell survival, cell death and the cell cycle, the end result is very ...
Yan Junjie J State Key Laboratory of Hybrid Rice, Department of Genetics, College of Life Sciences, Wuhan University, Wuhan 430072, People's Republic of - - 2014
miRNAs are involved in the pollen development during the CMS occurrence in rice. miRNAs are 20-24 nt endogenously expressed small RNAs that play key roles in the regulation of many growth and developmental processes in plants. The knowledge on cytoplasmic male sterility (CMS) regulation by miRNAs in rice is rather ...
Gaber Rania - - 2014
BackgroundEpidermal Growth Factor Receptor (EGFR) targeting therapies are currently of great relevance for the treatment of lung cancer. For this reason, in addition to mutational analysis immunohistochemistry (IHC) of EGFR in lung cancer has been discussed for the decision making of according therapeutic strategies. The aim of this study was ...
Wu Changgong C Rutgers University, United - - 2014
The dysregulation of protein oxidative post-translational modifications (PTMs) has been implicated in stress-related diseases. Trx1 is a key reductase that reduces specific disulfide bonds and other cysteine PTMs. Although commonly in the cytoplasm, Trx1 can also modulate transcription in the nucleus. However, few Trx1 nuclear targets have been identified due ...
Kim Won-Chan WC Department of Horticulture and Department of Forestry, Michigan State University, East Lansing, MI 48824-1222, USA; DOE-Great Lakes Bioenergy Research Center, Michigan State University, East Lansing, MI - - 2014
AtC3H14 (At1g66810) is a plant-specific tandem CCCH zinc finger (TZF) protein that belongs to the 68-member CCCH family in Arabidopsis thaliana. In animals, TZFs have been shown to bind and recruit target mRNAs to the cytoplasmic foci where mRNA decay enzymes are active. However, it is not known whether plant ...
Bloom Ryan J RJ Department of Bioengineering, Stanford University, Stanford, California, - - 2014
Synthetic genetic circuits incorporating regulatory components based on RNA interference (RNAi) have been used in a variety of systems. A comprehensive understanding of the parameters that determine the relationship between microRNA (miRNA) and target expression levels is lacking. We describe a quantitative framework supporting the forward engineering of gene circuits ...
Pascault Noémie N iEES Paris, UMR 7618 UPMC-CNRS-INRA-IRD-Paris 7-UPEC, 4 place Jussieu, 75005, Paris, - - 2014
Metatranscriptome analysis relates to the transcriptome of microbial communities directly sampled in the environment. Accessing the mRNA pool in natural bacterial communities presents some technical challenges such as the RNA extraction, rRNA depletion, and the choice of the high-throughput sequencing technique. The lack of technical details in scientific articles is ...
Ung Timothy H TH Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO, - - 2014
Exosomes are virus-sized, membrane enclosed vesicles with origins in the cellular endosomal system, but are released extracellularly. As a population, these tiny vesicles carry relatively enormous amounts of information in their protein, lipid, and nucleic acid content, and the vesicles can have profound impacts on recipient cells. This review employs ...
Zhang Lianglu L Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, No. 185, Donghu Road, Wuchang District, Wuhan, 430071, - - 2014
Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease, has broken out several times and was accompanied by neurological disease. microRNAs, a class of small non-coding RNAs that are approximately 20 nucleotides long, play important roles in the regulation of various biological processes, including antiviral defense. ...
Gentry Leanna R LR University of North Carolina at Chapel Hill, Department of Pharmacology, Chapel Hill, NC, - - 2014
Since their discovery in 1986, Ral (Ras-like) GTPases have emerged as critical regulators of diverse cellular functions. Ral-selective guanine nucleotide exchange factors (RalGEFs) function as downstream effectors of the Ras oncoprotein, and the RalGEF-Ral signaling network comprises the third best characterized effector of Ras-dependent human oncogenesis. Because of this, Ral ...
Cushing Leah L Boston University School of Medicine, Boston, Massachusetts, United States ; - - 2014
Decades of studies have shown evolutionarily conserved molecular networks consisting of transcriptional factors, diffusing growth factors, and signaling pathways that regulate proper lung development. Recently, miRNAs, small non-coding regulatory RNAs, have been integrated into these networks. Significant advances have been made in characterizing the developmental stage- or cell type-specific miRNAs ...
Xie Meng M Center for Plant Science Innovation and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68588-0660, - - 2014
microRNAs (miRNAs) are important regulators of gene expression. After excised from primary miRNA transcript by dicer-like1 (DCL1, an RNAse III enzyme), miRNAs bind and guide their effector protein named argonaute 1 (AGO1) to silence the expression of target RNAs containing their complementary sequences in plants. miRNA levels and activities are ...
Iwasaki Yasuno Y Department of Biochemistry and Cell Biology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794-5215, - - 2014
Alternative splicing of pre-mRNAs is an important means of regulating developmental processes, yet the molecular mechanisms governing alternative splicing in embryonic contexts are just beginning to emerge. Polyglutamine-binding protein 1 (PQBP1) is an RNA-splicing factor that, when mutated, in humans causes Renpenning syndrome, an X-linked intellectual disability disease characterized by ...
He Fan F F He, Orthopaedic Institute, Soochow University, Suzhou, 215007, China - - 2014
Both self-renewal and lineage-specific differentiation of mesenchymal stem cells are triggered by their in vivo microenvironment including the extracellular matrix (ECM) and secreted hormones. The ECM may modulate the physiological functions of hormones by providing binding sites and by regulating downstream signaling pathways. Thus, the purpose of this investigation was ...
Zhou Xiuping X Brain Hospital, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China; Insititute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, - - 2014
Protein kinase D2 (PKD2) has been demonstrated to promote tumorigenesis in many types of cancers. However, how PKD2 regulates cancer cell growth is largely unknown. In this study, we found that over-expression of PKD2 promoted glioma cell growth but down-regulation of PKD2 inhibited it. Further investigation indicated that PKD2 down-regulation ...
Lacroix Chrystelle C CNRS/UPS Toulouse, - - 2014
Obstructive nephropathy is a frequently encountered situation in newborns. In previous studies, the urinary peptidome has been analyzed for the identification of clinically useful biomarkers of obstructive nephropathy. However, the urinary proteome has not been explored yet and should allow additional insight into the pathophysiology of the disease. We have ...
Csibi Alfredo A Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, - - 2014
Growth-promoting signaling molecules, including the mammalian target of rapamycin complex 1 (mTORC1), drive the metabolic reprogramming of cancer cells required to support their biosynthetic needs for rapid growth and proliferation [1]. Glutamine is catabolyzed to α-ketoglutarate (αKG), a tricarboxylic acid (TCA) cycle intermediate, through two deamination reactions, the first requiring ...
Wilczynska A A MRC Toxicology Unit, University of Leicester, Leicester, - - 2014
Since their discovery 20 years ago, miRNAs have attracted much attention from all areas of biology. These short (∼22 nt) non-coding RNA molecules are highly conserved in evolution and are present in nearly all eukaryotes. They have critical roles in virtually every cellular process, particularly determination of cell fate in development ...
Curinha Ana A Gene Regulation Group of Institute for Molecular and Cellular Biology (IBMC); University of Porto; Porto, Portugal; Department of Biology; University of Aveiro; Aveiro, - - 2014
Polyadenylation is the RNA processing step that completes the maturation of nearly all eukaryotic mRNAs. It is a two-step nuclear process that involves an endonucleolytic cleavage of the pre-mRNA at the 3'-end and the polymerization of a polyadenosine (polyA) tail, which is fundamental for mRNA stability, nuclear export and efficient ...
Mitic Tijana T Bristol Heart Institute, School of Clinical Sciences, University of Bristol, England, - - 2014
Epigenetic mechanisms may regulate the expression of pro-angiogenic genes, thus affecting reparative angiogenesis in ischemic limbs. The enhancer of zest homolog-2 (EZH2) induces thtrimethylation of lysine 27 on histone H3 (H3K27me3), which represses gene transcription. We explored: 1) if EZH2 expression is regulated by hypoxia and ischemia; 2) the impact ...
Kumar Virender V Department of Pharmaceutical Sciences, University of Nebraska Medical Center (UNMC), 986025 Nebraska Medical Center, Omaha, Nebraska, 68198-6025, - - 2014
Liver fibrosis is a pathological condition originating from liver damage that leads to excess accumulation of extracellular matrix (ECM) proteins in the liver. Viral infection, chronic injury, local inflammatory responses and oxidative stress are the major factors contributing to the onset and progression of liver fibrosis. Multiple cell types and ...
Dayekh Khalil K Cancer Therapeutics, Ottawa Hospital Research - - 2014
Targeting the epidermal growth factor receptor (EGFR), with inhibitors such as erlotinib, represents a promising therapeutic option in advanced Head and Neck Squamous Cell Carcinomas (HNSCC). However, they lack significant efficacy as single agents. Recently, we identified the ability of statins to induce synergistic cytotoxicity in HNSCC cells through targeting ...
Ye Julia J The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Urology, University of California, San Francisco, San Francisco, CA 94143, - - 2014
Establishment, maintenance, and exit from pluripotency require precise coordination of a cell's molecular machinery. Substantial headway has been made in deciphering many aspects of this elaborate system, particularly with respect to epigenetics, transcription, and noncoding RNAs. Less attention has been paid to posttranscriptional regulatory processes such as alternative splicing, RNA ...
Jakob Sissi S Department of Neuroscience, School for Mental Health and Neuroscience (MHENS), Maastricht University, Maastricht, The - - 2014
Prenatal stress (PS) exposure is known to increase the risk of developing emotional disorders like major depression in later life. However, some individuals do not succumb to adversity following developmental stress exposure, a phenomenon referred to as resilience. To date, the molecular mechanisms explaining why some subjects are vulnerable and ...
Van Pham Phuc P Laboratory of Stem Cell Research and Application, University of Science, Vietnam National University, Ho Chi Minh City, Viet Nam. Electronic address: - - 2014
Numerous studies have sought to identify diabetes mellitus treatment strategies with fewer side effects. Mesenchymal stem cell (MSC) therapy was previously considered as a promising therapy; however, it requires the cells to be trans-differentiated into cells of the pancreatic-endocrine lineage before transplantation. Previous studies have shown that PDX-1 expression can ...
Ma Jun J 1] Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, People's Republic of China [2] Institute of Pathology and Pathophysiology, China Medical University, Shenyang, People's Republic of - - 2014
Blood-tumor barrier (BTB) constitutes an efficient organization of tight junctions that impairs the delivery of therapeutic drugs. However, the methods and molecular mechanisms underlying the BTB opening remain elusive. MicroRNAs (miRNAs) have recently emerged as key regulators of various biologic processes and therapeutic targets. In this study, we have identified ...
Chiarella-Redfern H H HH Division of Cardiac Surgery Genomics and Cell Biology Group University of Ottawa Heart Institute, and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa ON, - - 2014
MicroRNAs (miRNAs) are small, non-messenger RNAs, 20-22 nucleotides in size, which regulate gene expression at the post-transcriptional level. Typically, miRNAs target the 3' untranslated region (3'UTR) of mRNA transcripts leading to mRNA degradation or translational repression. The known dysregulation of miRNAs during cardiac ischemia and the crucial role of miRNA-dependent ...
Muthusamy Senthilkumar S University of Louisville, United - - 2014
Derangements in metabolism and related signaling pathways characterize the failing heart. One such signal, O-linked β-N-acetylglucosamine (O-GlcNAc), is an essential post-translational modification regulated by two enzymes, O-GlcNAc transferase and O-GlcNAcase, which modulate function of many nuclear and cytoplasmic proteins. We recently reported reduced OGA expression in the failing heart, which ...
Guan Fuqin F Jiangsu Key Laboratory for Bioresources of Saline Soils, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences/Nanjing Botanical Garden Memorial Sun Yat-Sen, Nanjing, Jiangsu 210014, P.R. China ; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. - - 2014
Lonimacranthoide VI, first isolated from the flower buds of Lonicera macranthoides in our previous study, is a rare chlorogenic acid ester acylated at C-23 of hederagenin. In the present study, the anti-inflammatory effects of lonimacranthoide VI were studied. Lipopolysaccharides (LPS) induced an inflammatory response through the production of prostaglandin E2 ...
Kurosaki Tatsuaki T Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA; Center for RNA Biology, University of Rochester, Rochester, New York 14642, - - 2014
Nonsense-mediated mRNA decay (NMD) controls the quality of eukaryotic gene expression and also degrades physiologic mRNAs. How NMD targets are identified is incompletely understood. A central NMD factor is the ATP-dependent RNA helicase upframeshift 1 (UPF1). Neither the distance in space between the termination codon and the poly(A) tail nor ...
Schacht Theresa T Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, D-07747 Jena, Erlanger Allee 101, Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Beutenbergstrasse 11a, 07745 Jena, Theoretical Bioinformatics, German Cancer Research Center, INF 580, 69121 Heidelberg, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, and Bioquant, University of Heidelberg, Im Neuenheimer Feld 267 and Division Translational Immunology, Group Tumor Antigens, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, D-07747 Jena, Erlanger Allee 101, Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Beutenbergstrasse 11a, 07745 Jena, Theoretical Bioinformatics, German Cancer Research Center, INF 580, 69121 Heidelberg, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, and Bioquant, University of Heidelberg, Im Neuenheimer Feld 267 and Division Translational Immunology, Group Tumor Antigens, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, D-07747 Jena, Erlanger Allee 101, Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Beutenbergstrasse 11a, 07745 Jena, Theoretical Bioinformatics, German Cancer Research Center, INF 580, 69121 Heidelberg, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, and Bioquant, University of Heidelberg, Im Neuenheimer Feld 267 and Division Translational Immunology, Group Tumor Antigens, German Cancer - - 2014
Understanding regulation of transcription is central for elucidating cellular regulation. Several statistical and mechanistic models have come up the last couple of years explaining gene transcription levels using information of potential transcriptional regulators as transcription factors (TFs) and information from epigenetic modifications. The activity of TFs is often inferred by ...
Zhang Junpeng J Faculty of Engineering, Dali University, Dali, CN. Electronic address: - - 2014
Discovering the regulatory relationships between microRNAs (miRNAs) and mRNAs is an important problem that interests many biologists and medical researchers. A number of computational methods have been proposed to infer miRNA-mRNA regulatory relationships, and are mostly based on the statistical associations between miRNAs and mRNAs discovered in observational data. The ...
Yin Jinlong J Specific Organs Cancer Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi , Korea. These authors contributed equally to this - - 2014
Glioma stemness has been recognized as the most important reason for glioma relapse and drug resistance. Differentiation of glioma stem cells (GSCs) has been implicated as a novel approach to target recurrent glioma. However, the detailed molecular mechanism involved in the differentiation of GSCs has not yet been elucidated. This ...
Wang Pei P Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, 36 Wuluju, Chaoyang District, Beijing, 100029, - - 2014
Hypertrophic cardiomyopathy (HCM) is a leading cause of heart failure and sudden death in adolescents and young adults. Recently, the role of the Hippo/YAP pathway has been investigated in the pathogenesis of HCM, although the detailed molecular mechanisms largely remain elusive. In this study, we demonstrated an up-regulation of YAP ...
Hahn Cynthia K CK Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH, United - - 2014
Fetal hemoglobin (HbF) induction can ameliorate the clinical severity of sickle cell disease and β-thalassemia. We previously reported that activation of the eukaryotic initiation factor 2α (eIF2α) stress pathway increased HbF through a post-transcriptional mechanism. In this study, we explored the underlying means by which salubrinal, an activator of eIF2α ...
Lee Mihye M IBS Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, - - 2014
Although more than 100 types of RNA modification have been described thus far, most of them were thought to be rare in mRNAs and in regulatory noncoding RNAs. Recent developments have unveiled that at least some of the modifications are considerably abundant and widely conserved. This Minireview summarizes the molecular ...
Peter Stefan S Oncology, University of - - 2014
Purpose: Loss of epigenetic gene regulation through altered long non-coding RNA (lncRNA) expression appears important in human cancer. LncRNAs have diagnostic and therapeutic potential, and offer insights into the biology disease, but little is known of their expression in urothelial cancer (UC). Here we identify differentially expressed lncRNAs with potential ...
He Dongxu D National Engineering Laboratory for Cereal Fermentation - - 2014
We previously demonstrated that the over-expression of transient receptor potential channel C5 (TRPC5) and nuclear factor of activated T-cells isoform c3 (NFATC3) are essential for cancer chemoresistance, but how TRPC5 and NFATC3 are regulated was still unclear. In this study, microRNA 320a (miR-320a) was found to be down-regulated in chemoresistant ...
Kelly Michy P MP Department of Pharmacology, Physiology & Neuroscience University of South Carolina School of Medicine 6439 Garners Ferry Road VA Bldg 1, 3rd Floor, D-12 Columbia, SC 29208. - - 2014
Phosphodiesterase 11A (PDE11A) is the most recently discovered 3',5'-cyclic nucleotide phosphodiesterase. By breaking down both cAMP and cGMP, PDE11A is a critical regulator of intracellular signaling. To date, PDE11A has been implicated to play a role in tumorigenesis, brain function, and inflammation. Here, we consolidate and, where necessary, reconcile the ...
Wong Mandy S MS Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390-9039, - - 2014
Alternative splicing affects approximately 95% of eukaryotic genes, greatly expanding the coding capacity of complex genomes. Although our understanding of alternative splicing has increased rapidly, current knowledge of splicing regulation has largely been derived from studies of highly expressed mRNAs. Telomerase is a key example of a protein that is ...
Zhao Ruibin R Department of Pediatrics, Zhongda Hospital, Southeast - - 2014
Ocular neovascularization is a vision-threatening complication of ischemic retinopathy that develops in various ocular disorders, such as retinopathy of prematurity (ROP) and diabetic retinopathy. Both Ang-2 and VEGF are implicated in this pathogenesis. However, their inter-regulation still remains elusive. Competitive endogenous RNAs (ceRNAs) are messenger RNA (mRNA) molecules that affect ...
Cheng Chun-Ting CT Chun-Ting Cheng, Ching-Ying Kuo, David K Ann, Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, CA 91010-3000, United - - 2014
KAP1/TRIM28/TIF1β was identified nearly twenty years ago as a universal transcriptional co-repressor because it interacts with a large KRAB-containing zinc finger protein (KRAB-ZFP) transcription factor family. Many studies demonstrate that KAP1 affects gene expression by regulating the transcription of KRAB-ZFP-specific loci, trans-repressing as a transcriptional co-repressor or epigenetically modulating chromatin ...
Tan Sean Yang-Yi SY Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore 637551 School of Biological Sciences, Nanyang Technological University, Singapore - - 2014
Food is now recognized as a natural resource of novel antimicrobial agents including those that target the virulence mechanisms of bacterial pathogens. Iberin, an isothiocyanate compound from horseradish, was recently identified as a quorum sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa. Here, we used a comparative systems biology ...
Sasse Sarah K SK Department of Medicine, National Jewish Health, Denver, CO, - - 2014
Nuclear receptors (NRs) are widely targeted to treat a range of human diseases. Feed-forward loops are an ancient mechanism through which single cell organisms organize transcriptional programming and modulate gene expression dynamics, but they have not been systematically studied as a regulatory paradigm for NR-mediated transcriptional responses. Here, we provide ...
Kowalska Joanna J Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Warsaw, - - 2014
Modified mRNA cap analogs aid in the study of mRNA-related processes and may enable creation of novel therapeutic interventions. We report the synthesis and properties of 11 dinucleotide cap analogs bearing a single boranophosphate modification at either the α-, β- or γ-position of the 5',5'-triphosphate chain. The compounds can potentially ...
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