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Zhao Lianggong L The Second Clinical Medical College of Lanzhou University, 82 Cuiying Men, Lanzhou 730030, PR China; Orthopaedics Key Laboratory of Gansu Province, Lanzhou 730000, PR - - 2014
Radix Hedysari polysaccharides (HPS) is the principal active fraction of Radix Hedysari (RH). The information about HPS3d, the main fraction of HPS3, and its effect on bone is still unknown. In the present study, the purified HPS3d was obtained by anion-exchange column. It consisted of 94.38% polysaccharide, 3.40% protein and ...
Guan Fuqin F Jiangsu Key Laboratory for Bioresources of Saline Soils, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences/Nanjing Botanical Garden Memorial Sun Yat-Sen, Nanjing, Jiangsu 210014, P.R. China ; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. - - 2014
Lonimacranthoide VI, first isolated from the flower buds of Lonicera macranthoides in our previous study, is a rare chlorogenic acid ester acylated at C-23 of hederagenin. In the present study, the anti-inflammatory effects of lonimacranthoide VI were studied. Lipopolysaccharides (LPS) induced an inflammatory response through the production of prostaglandin E2 ...
Liu Bo B FIRST, Aihara Innovative Mathematical Modelling Project, Japan Science and Technology Agency, Tokyo, Japan Institute of Industrial Science, The University of Tokyo, Tokyo, Japan Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China, Xidian University, Xi'an, People's Republic of - - 2014
Gene transcription is a noisy process carried out by the transcription machinery recruited to the promoter. Noise reduction is a fundamental requirement for reliable transcriptional responses which in turn are crucial for signal transduction. Compared with the relatively simple transcription initiation in prokaryotes, eukaryotic transcription is more complex partially owing ...
Anwar-Mohamed Anwar A Faculty of Pharmacy and Pharmaceutical Sciences, 2142J Katz Group-Rexall Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB T6G 2E1, - - 2014
The toxic effects of arsenic on the whole brain, as well as the discrete regions, has been previously reported for mice. We investigated the effects of acute arsenite (As(III)) on brain levels of arachidonic acid (AA) and its associated metabolites generated through cytochrome P450 (CYP), cyclooxygenase (COX), and lipoxygenase (LOX) ...
O'Hara Andrew - - 2014
Nucleolar sequestration of RelA is an important mechanism for regulating NF-κB transcriptional activity. COMMD1(MURR1) facilitated ubiquitination acts as a critical nucleolar targeting signal for RelA, but how this ubiquitination is regulated, and how it differs from cytokine-mediated ubiquitination which causes proteasomal degradation of RelA, is poorly understood. Here we report ...
Jackson Angelyca A AA Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, - - 2014
Hemolytic phospholipase C (PlcH) is a potent virulence and colonization factor that is highly expressed by Pseudomonas aeruginosa within the mammalian host. The phosphorylcholine liberated from phosphatidylcholine and sphingomyelin by PlcH is further catabolized into molecules that both support growth and further induce plcH expression. We have shown previously that ...
Almeida Luis Eduardo LE Department of Oral Sciences, Oral Surgery, Marquette University, School of Dentistry, Milwaukee, WI, - - 2014
Matrix metalloproteases (MMPs) are tissue-remodeling enzymes that function during the remodeling process, such as in immune-inflammatory diseases. Metalloprotease-2 (MMP-2) and metalloprotease-9 (MMP-9) are gelatinases that degrade several types of extracellular matrix collagen. It is hypothesized that in temporomandibular joint (TMJ) dysfunction, MMP-2 and MMP-9 expression levels may be elevated. Therefore, ...
Edwards Adrianne N AN Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, - - 2014
The anaerobic gastrointestinal pathogen Clostridium difficile must form a metabolically dormant spore to survive in oxygenic environments and be transmitted from host to host. The regulatory factors by which C. difficile initiates and controls the early stages of sporulation in C. difficile are not highly conserved with other Clostridium or ...
Chen Jianping J Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, - - 2014
The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed as a health supplement worldwide. To study the role of jujube in brain benefits, the expression of neurotrophic factors and anti-oxidant enzymes in the jujube-treated cultured astrocytes was determined. Application of a chemical standardized water ...
Zhang Yingqian Y Department of Cardiology, Chinese PLA General Hospital, 28 Fuxing Rd, Beijing, 100853, - - 2014
Hypoxia/reoxygenation (H/R) is one of the cellular stresses in pathological conditions, such as myocardial infarction, stroke and organ transplantation. Oxidative stress caused by reactive oxygen species (ROS) is a crucial element of H/R injury in vascular endothelial cells (ECs). Xanthine oxidase (XO) has been recognized to contribute to H/R injury. ...
Yin Chaomin C Key Laboratory of Agro-Microbial Resources and Utilization, Ministry of Agriculture, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, - - 2014
The full-length cDNA of Pleurotus ostreatus superoxide dismutase (PoMn-SOD) was cloned and successfully expressed by using the pPIC9K vector under the control of alcohol oxidase 1 promoter with a secretion signal peptide (α-factor) in Pichia pastoris. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blotting demonstrated that recombinant PoMn-SOD, a ...
Guida Natascia N Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatologic Sciences, School of Medicine, "Federico II" University of Naples, Via Pansini, 5, 80131 Naples, - - 2014
Phthalates, phthalic acid esters, are widely used as plasticizers to produce polymeric materials in industrial production of plastics and daily consumable products. Animal studies have shown that di(2-ethylhexyl)phthalate (DEHP) may cause toxic effects in rat brain. In the present study, chronic exposure to DEHP (0.1-100μM) caused dose-dependent cell death via ...
Boesmans Leen L Translational Research Center for Gastrointestinal Disorders (TARGID) and Leuven Food Science and Nutrition Research Centre (LFoRCe), University Hospital Gasthuisberg, KU Leuven, Herestraat 49 0&N1 box 701, 3000 Leuven, - - 2014
In ulcerative colitis (UC) the butyrate metabolism is impaired, leading to energy-deficiency in the colonic cells. The effect of inflammation on the butyrate metabolism was investigated. HT-29 cells were incubated with pro-inflammatory cytokines (TNF-α and/or IFN-γ) for 1h and 24h. Cells were additionally stimulated with butyrate to investigate its anti-inflammatory ...
Li Gang G Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, - - 2014
When Escherichia coli is grown in a medium lacking glucose or another preferred carbohydrate, the concentration of cyclic cAMP-cAMP receptor protein (cAMP-CRP) increases, and this latter complex regulates the expression of more than 180 genes. To respond rapidly to changes in carbohydrate availability, E. coli must maintain a suitable intracellular ...
Jeong Kwon K Department of Biochemistry and Molecular Biology (BK21 project), Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, #1, Hoegi-dong, Dongdaemoon-gu, Seoul, 130-701, Republic of - - 2014
Apelin, which is an endogenous ligand for the orphan G-protein-coupled receptor APJ, was reported to be up-regulated by hypoxia-inducible factor 1-α (HIF1-α) in hypoxia- and insulin-treated cell systems. However, a negative transcriptional regulator of apelin has not yet been identified. In this study, we showed that apelin is down-regulated by ...
Markell Lauren K LK DuPont Haskell Global Centers for Health and Environmental Sciences , Newark, Delaware 19714, United - - 2014
Xenobiotics may activate the estrogen receptor, resulting in alteration of normal endocrine functions in animals and humans. Consequently, this necessitates development of assay end points capable of identifying estrogenic xenobiotics. In the present study, we screened the potential estrogenicity of chemicals via their ability to induce vitellogenin (VTG) expression in ...
Wang C - - 2014
In addition to being positively regulated by prandial activity, bile acid production is also negatively controlled by the endocrine fibroblast growth factor 19 (FGF19) or the mouse ortholog FGF15 from the ileum that represses hepatic cholesterol 7 α-hydroxylase (Cyp7a1) expression through activating FGF receptor four (FGFR4). However, how these two ...
Zhang Junpeng J Faculty of Engineering, Dali University, Dali, CN. School of Information Technology and Mathematical Sciences, University of South Australia, AU. Children's Cancer Institute Australia, Randwick NSW 2301, AU. Kunming University of Science and Technology, Kunming, CN. Centre for Cancer Biology, SA Pathology, SA 5000, - - 2014
microRNAs (miRNAs) play crucial roles in complex cellular networks by binding to the messenger RNAs (mRNAs) of protein coding genes. It has been found that miRNA regulation is often condition-specific. A number of computational approaches have been developed to identify miRNA activity specific to a condition of interest using gene ...
Tudek Agnieszka A Centre de Génétique Moléculaire, CNRS UPR3404, 91190 Gif sur Yvette, - - 2014
The Nrd1-Nab3-Sen1 (NNS) complex is essential for controlling pervasive transcription and generating sn/snoRNAs in S. cerevisiae. The NNS complex terminates transcription of noncoding RNA genes and promotes exosome-dependent processing/degradation of the released transcripts. The Trf4-Air2-Mtr4 (TRAMP) complex polyadenylates NNS target RNAs and favors their degradation. NNS-dependent termination and degradation are coupled, ...
Nicholson Pamela P Department of Chemistry and Biochemistry, University of Berne, Berne, CH-3012, - - 2014
Eukaryotic mRNAs with premature translation-termination codons (PTCs) are recognized and eliminated by nonsense-mediated mRNA decay (NMD). NMD substrates can be degraded by different routes that all require phosphorylated UPF1 (P-UPF1) as a starting point. The endonuclease SMG6, which cleaves mRNA near the PTC, is one of the three known NMD ...
Ravasi Giulia G Department of Health Science, University Milano-Bicocca, Monza, - - 2014
Hepcidin transcription is strongly down-regulated under hypoxic conditions, however whether hypoxia inhibits hepcidin directly or indirectly is still unknown. We investigated the time course of hypoxia-mediated hepcidin down-regulation in vivo in healthy volunteers exposed to hypobaric hypoxia at high altitude and, based on the hypothesis that circulating factors are implicated ...
Shridhar Varsha - - 2014
The CD8 Antiviral Factor (CAF) suppresses viral transcription from the HIV-1 Long Terminal Repeat (LTR) promoter in a non-cytolytic manner. However, the region on the LTR upon which CAF acts is unknown. Our objective was to determine the region on the LTR upon which CAF acts to suppress HIV-1 transcription. ...
Wang Bing B State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Wuhan 430072, - - 2014
Mammalian viperin is a typical interferon (IFN)-induced antiviral protein. Fish have viperin homologs; however, little is known about the expression regulation of fish viperins. In this study, we report the expression regulation and antiviral function of a fish viperin from crucian carp Carassius auratus during IFN response. Crucian carp viperin ...
Yamamoto Kaneyoshi K Department of Frontier Bioscience, Hosei University, - - 2014
Expression pattern of the genome in Escherichia coli is controlled by regulating the utilization of a limited number of RNA polymerase between a total of 4,600 genes on its genome. The distribution pattern of RNA polymerase on the genome changes after two steps of protein-protein interaction with 7 sigma subunits ...
Liu Xuewei X R&D Center for Petrochemical Technology, Tianjin University, Tianjin 300072, China; Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People's Republic of - - 2014
There has been little research reported on the synergism of plant expansins in cellulose hydrolysis because of the difficulty of heterologous expression. In this study, the expansin gene LeExp2 of Lycopersicum esculentum was expressed for the first time in Pichia pastoris to identify its function in vitro. The optimal expression ...
Huang Xiaobo X Department of Chinese Medicine, Xuanwu Hospital, Capital Medical University , Beijing , China - - 2014
Abstract Context: DTD is a Chinese herb prescription used for centuries to treat atherosclerosis or dizziness. Previous studies show that DTD could inhibit ICAM-1 expression induced by TNF-α. However, its mechanism has never been clearly described. Objective: To examine the hypothesis that DTD might inhibit TNF-α-induced ICAM-1 expression through regulating ...
Wang Chen-Hsu CH Medical Intensive Care Unit, Cathay General Hospital , Taipei , Taiwan - - 2014
Abstract Background: Carbamazepine, which was developed primarily for the treatment of epilepsy, is now also useful for the treatment of non-epileptic disorders and inflammatory hyperalgesia. However, the mechanism of its anti-neuroinflammatory action remains poorly understood. Objective: This study elucidates the anti-neuroinflammatory capacity of carbamazepine on microglial activation and the relative ...
Domitrović Robert R Department of Chemistry and Biochemistry, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia. Electronic address: - - 2014
The aim of this study was to investigate the renoprotective activity of chlorogenic acid (CA) in a murine model of cisplatin (CP)-induced kidney injury. Male BALB/cN mice were gavaged daily with CA at 3, 10 and 30mg/kg for two successive days, 48h after intraperitoneal injection of CP (13mg/kg). On the ...
Lee So-Hyoung SH Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-921, Republic of - - 2014
Bahamaolide A, a new macrocyclic lactone isolated from the culture of marine actinomycete Streptomyces sp. CNQ343, was evaluated for its inhibitory activity toward isocitrate lyase (ICL) from Candida albicans. These studies led to the identification of bahamaolide A as a potent ICL inhibitor with IC50 value of 11.82μM. The growth ...
Pathak R R Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, - - 2014
Endothelial thrombomodulin (TM) is critically involved in anti-coagulation, anti-inflammation, cytoprotection, and normal fetal development. Tumor necrosis factor alpha (TNF) suppresses TM expression. TNFα has been shown to down-regulate TM partly via activation of nuclear factor kappa B (NF-B). However, because the TM promoter lacks an NF-κB binding site, the direct ...
Kasperova Alena A Department of Immunology, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Olomouc, Czech - - 2014
Cysteine dioxygenase (CDO) is involved in regulation of intracellular cysteine levels by catabolising the cysteine to sulphite and sulphate. In keratinolytic fungi, sulphite is actively excreted to reduce disulphide bridges in keratin before its enzymatic degradation. The pathogenicity role of CDO was confirmed in cysteine-hypersensitive and growth-defective ΔCdo mutant of ...
Zhao Shengqiang S Center for Vascular Biology Research, Division of Molecular and Vascular Biology, and Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA;Center for Vascular Biology Research, Division of Molecular and Vascular Biology, and Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA; Department of Gastroenterology, Provincial Hospital Affiliated to Shandong University, Ji-nan, - - 2014
Angiogenesis is a hallmark of many diseases, including cancer, ischemic heart disease, inflammation, and others. It is well known that vascular endothelial growth factor (VEGF) is the most important angiogenic factor. Recently, we demonstrated that orphan nuclear receptor TR3 (mouse Nur77 and rat NGFI-B) plays critical roles in tumor growth ...
Burns Michael L ML Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, - - 2014
Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system function and has therapeutic potential. Microbial production of BDNF has resulted in low fidelity protein product, often in the form of large insoluble aggregates incapable of binding to cognate TrkB or p75 receptors. In this study, employing yeast display ...
Xia Ning - - 2014
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) possesses multiple protective properties in the vasculature, including anti-oxidative and anti-inflammatory effects and improvement of endothelial function. A substantial part of these effects is attributable to gene expression changes induced by the compound. Resveratrol can activate the NAD-dependent deacetylase sirtuin 1 (SIRT1), leading to deacetylation of SIRT1 target ...
Chen Ming M Thomas Jefferson University, United - - 2014
Protein arginine methyltransferase 5 (PRMT5), a protein arginine methyltransferase that catalyzes the symmetrical dimethylation of arginine residues within target proteins, has been implicated in many essential cellular processes, ranging from the regulation of gene expression to cell proliferation and differentiation. PRMT5 is highly expressed in the heart, the functional role ...
Du Minmin M State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China College of Horticulture, Northeast Agricultural University, Harbin 150030, - - 2014
To restrict pathogen entry, plants close stomata as an integral part of innate immunity. To counteract this defense, Pseudomonas syringae pv tomato produces coronatine (COR), which mimics jasmonic acid (JA), to reopen stomata for bacterial entry. It is believed that abscisic acid (ABA) plays a central role in regulating bacteria-triggered ...
Templeton Neil N Department of Chemical and Biomolecular Engineering, Vanderbilt University; PMB 351604, 2301 Vanderbilt Place, Nashville, TN, 37235-1604, - - 2014
Anti-apoptosis engineering is an established technique to prolong the viability of mammalian cell cultures used for industrial production of recombinant proteins. However, the effect of overexpressing anti-apoptotic proteins on central carbon metabolism has not been systematically studied. We transfected CHO-S cells to express Bcl-2∆, an engineered anti-apoptotic gene, and selected ...
Iyer Srividhya S University of Arkansas for Medical Sciences, United - - 2014
A decline of the levels and activity of Sirtuin1 (Sirt1), a NAD+ class III histone deacetylase, with age contributes to the development of several diseases including type 2 diabetes, neurodegeneration, inflammation, and cancer. The anti-aging effects of Sirt1 evidently result from the deacetylation of many transcription factors and co-factors including ...
Hong Sohyun S Department of Life Science and the Research Center for Cellular Homeostasis, Ewha Womans University, Seoul 120-750, - - 2014
We previously reported the inhibitory role of thioredoxin-related protein of 14 kDa (TRP14), a novel disulfide reductase in nuclear factor-κB (NF-κB) activation, but its biological function has remained to be explored. Here, we evaluated the role of TRP14 in the differentiation and function of osteoclast (OC), for which NF-κB and ...
Ehira Shigeki S Department of Biological Sciences, Graduate school of Science and Engineering, Tokyo Metropolitan University, Hachioji, Tokyo, JapanDepartment of Biological Science, Faculty of Science and Engineering, Chuo University, Bunkyo-ku, Tokyo, Japan Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan - - 2014
The filamentous, nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120 accumulates sucrose as a compatible solute against salt stress. Sucrose-phosphate synthase activity, which is responsible for the sucrose synthesis, is increased by salt stress, but the mechanism underlying the regulation of sucrose synthesis remains unknown. In the present study, a response ...
Ing Nancy H NH Department of Animal Science, Texas A&M AgriLife Research. Electronic address: - - 2014
In rodents, livestock and primate species, a single dose of the synthetic glucocorticoid dexamethasone acutely lowers testosterone biosynthesis. To determine the mechanism of decreased testosterone biosynthesis, stallions were treated with 0.1mg/kg dexamethasone 12h prior to castration. Dexamethasone decreased serum concentrations of testosterone by 60% compared to saline-treated control stallions. Transcriptome ...
Yadav Poonam P a National Bureau of Animal Genetic Resources , Karnal , - - 2014
Lactation is an important physiological process in dairy animals. During lactation, up to 85% of the body glucose is directed toward the mammary glands for milk synthesis. Studies related to lactation physiology are generally carried out on mammary biopsies, which may adversely affect animal health. In the present study, milk ...
Wright P W PW Basic Science Program, Leidos Biomedical Research Inc., Lab of Experimental Immunology, Frederick National Lab, Frederick, MD, - - 2014
Members of the human KIR (killer cell immunoglobulin-like receptor) class I major histocompatibility complex receptor gene family contain multiple promoters that determine the variegated expression of KIR on natural killer cells. In order to identify novel genetic alterations associated with decreased KIR expression, a group of donors was characterized for ...
Zhou Xiaoming X Uniformed Services University of the Health Sciences - - 2014
Visceral leishmaniasis patients have been reported to have a urine concentration defect. Concentration of urine by the renal inner medulla is essentially dependent on a transcription factor, NFAT5/TonEBP, because it activates expression of osmoprotective genes BGT1 and SMIT, and water channel aquaporin-2, all of which are imperative for concentrating urine. ...
Lu Jing-Jing JJ State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, - - 2014
In response to deprivation of combined nitrogen, the filamentous cyanobacterium Anabaena sp. strain PCC 7120 develops heterocyst, which is specifically involved in the nitrogen fixation. In this study, we focused on the regulation of HanA, a histone-like protein, in heterocyst development. Electrophoretic mobility shift assay results showed that NtcA, a ...
Li Yan Y The MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy & Biotechnology, China Agricultural University, Beijing 100193, - - 2014
The type III secretion system (T3SS) is a major virulence factor in many Gram-negative bacterial pathogens and represents a particularly appealing target for antimicrobial agents. Previous studies have shown that the plant phenolic compound p-coumaric acid (PCA) plays a role in inhibiting the T3SS expression of the phytopathogen D. dadantii ...
Clayton C E CE Universität Heidelberg, Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany. Electronic address: - - 2014
Regulation of gene expression in Kinetoplastids relies mainly on post-transcriptional mechanisms. Recent high-throughput analyses, combined with mathematical modelling, have demonstrated possibilities for transcript-specific regulation at every stage: trans splicing, polyadenylation, translation, and degradation of both the precursor and the mature mRNA. Different mRNA degradation pathways result in different types of ...
Verma Amit Kumar AK Molecular Biophysics Unit, Indian Institute of Science, - - 2014
MsRbpA is a RNA polymerase (RNAP) binding protein from Mycobacterium smegmatis. According to our earlier studies, MsRbpA rescues rifampicin induced transcription inhibition upon binding to the RNAP. Hu et al., (2012) showed that RbpA from Mycobacterium tuberculosis (MtbRbpA) is a transcription activator. In this study, we report that both MsRbpA ...
Pillai-Kastoori Lakshmi L Department of Biology, University of Kentucky, Lexington, Kentucky, United States of - - 2014
Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts. Although Hedgehog signaling is known to play a critical role in choroid fissure closure, genetic regulation of this pathway ...
Chahar Sanjay S Human Genetics Institute of New Jersey and the Department of Genetics, Rutgers, the State University of New Jersey, Piscataway, - - 2014
Transcriptional regulatory mechanisms likely contribute to the etiology of Inflammatory Bowel Disease (IBD), as genetic variants associated with the disease are disproportionately found at regulatory elements. However, the transcription factors regulating colonic inflammation are unclear. To identify these transcription factors, we mapped epigenomic changes in the colonic epithelium upon inflammation. ...
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