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Zhao Lianggong L The Second Clinical Medical College of Lanzhou University, 82 Cuiying Men, Lanzhou 730030, PR China; Orthopaedics Key Laboratory of Gansu Province, Lanzhou 730000, PR - - 2014
Radix Hedysari polysaccharides (HPS) is the principal active fraction of Radix Hedysari (RH). The information about HPS3d, the main fraction of HPS3, and its effect on bone is still unknown. In the present study, the purified HPS3d was obtained by anion-exchange column. It consisted of 94.38% polysaccharide, 3.40% protein and ...
Weaver Ian C G IC Department of Psychology and Neuroscience, Dalhousie University, Life Science Research Institute, 1348 Summer Street, Halifax, Nova Scotia, Canada B3H - - 2014
Variations in maternal care in the rat influence the epigenetic state and transcriptional activity of glucocorticoid receptor (GR) gene in the hippocampus. The mechanisms underlying this maternal effect remained to be defined, including the nature of the relevant maternally regulated intracellular signalling pathways. We show here that increased maternal licking/grooming ...
Guan Fuqin F Jiangsu Key Laboratory for Bioresources of Saline Soils, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences/Nanjing Botanical Garden Memorial Sun Yat-Sen, Nanjing, Jiangsu 210014, P.R. China ; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. - - 2014
Lonimacranthoide VI, first isolated from the flower buds of Lonicera macranthoides in our previous study, is a rare chlorogenic acid ester acylated at C-23 of hederagenin. In the present study, the anti-inflammatory effects of lonimacranthoide VI were studied. Lipopolysaccharides (LPS) induced an inflammatory response through the production of prostaglandin E2 ...
Schacht Theresa T Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, D-07747 Jena, Erlanger Allee 101, Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Beutenbergstrasse 11a, 07745 Jena, Theoretical Bioinformatics, German Cancer Research Center, INF 580, 69121 Heidelberg, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, and Bioquant, University of Heidelberg, Im Neuenheimer Feld 267 and Division Translational Immunology, Group Tumor Antigens, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, D-07747 Jena, Erlanger Allee 101, Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Beutenbergstrasse 11a, 07745 Jena, Theoretical Bioinformatics, German Cancer Research Center, INF 580, 69121 Heidelberg, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, and Bioquant, University of Heidelberg, Im Neuenheimer Feld 267 and Division Translational Immunology, Group Tumor Antigens, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, D-07747 Jena, Erlanger Allee 101, Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Beutenbergstrasse 11a, 07745 Jena, Theoretical Bioinformatics, German Cancer Research Center, INF 580, 69121 Heidelberg, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, and Bioquant, University of Heidelberg, Im Neuenheimer Feld 267 and Division Translational Immunology, Group Tumor Antigens, German Cancer - - 2014
Understanding regulation of transcription is central for elucidating cellular regulation. Several statistical and mechanistic models have come up the last couple of years explaining gene transcription levels using information of potential transcriptional regulators as transcription factors (TFs) and information from epigenetic modifications. The activity of TFs is often inferred by ...
Wang Pei P Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, 36 Wuluju, Chaoyang District, Beijing, 100029, - - 2014
Hypertrophic cardiomyopathy (HCM) is a leading cause of heart failure and sudden death in adolescents and young adults. Recently, the role of the Hippo/YAP pathway has been investigated in the pathogenesis of HCM, although the detailed molecular mechanisms largely remain elusive. In this study, we demonstrated an up-regulation of YAP ...
Hahn Cynthia K CK Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH, United - - 2014
Fetal hemoglobin (HbF) induction can ameliorate the clinical severity of sickle cell disease and β-thalassemia. We previously reported that activation of the eukaryotic initiation factor 2α (eIF2α) stress pathway increased HbF through a post-transcriptional mechanism. In this study, we explored the underlying means by which salubrinal, an activator of eIF2α ...
Lee Mihye M IBS Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, - - 2014
Although more than 100 types of RNA modification have been described thus far, most of them were thought to be rare in mRNAs and in regulatory noncoding RNAs. Recent developments have unveiled that at least some of the modifications are considerably abundant and widely conserved. This Minireview summarizes the molecular ...
Peter Stefan S Oncology, University of - - 2014
Purpose: Loss of epigenetic gene regulation through altered long non-coding RNA (lncRNA) expression appears important in human cancer. LncRNAs have diagnostic and therapeutic potential, and offer insights into the biology disease, but little is known of their expression in urothelial cancer (UC). Here we identify differentially expressed lncRNAs with potential ...
He Dongxu D National Engineering Laboratory for Cereal Fermentation - - 2014
We previously demonstrated that the over-expression of transient receptor potential channel C5 (TRPC5) and nuclear factor of activated T-cells isoform c3 (NFATC3) are essential for cancer chemoresistance, but how TRPC5 and NFATC3 are regulated was still unclear. In this study, microRNA 320a (miR-320a) was found to be down-regulated in chemoresistant ...
Kelly Michy P MP Department of Pharmacology, Physiology & Neuroscience University of South Carolina School of Medicine 6439 Garners Ferry Road VA Bldg 1, 3rd Floor, D-12 Columbia, SC 29208. - - 2014
Phosphodiesterase 11A (PDE11A) is the most recently discovered 3',5'-cyclic nucleotide phosphodiesterase. By breaking down both cAMP and cGMP, PDE11A is a critical regulator of intracellular signaling. To date, PDE11A has been implicated to play a role in tumorigenesis, brain function, and inflammation. Here, we consolidate and, where necessary, reconcile the ...
Wong Mandy S MS Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390-9039, - - 2014
Alternative splicing affects approximately 95% of eukaryotic genes, greatly expanding the coding capacity of complex genomes. Although our understanding of alternative splicing has increased rapidly, current knowledge of splicing regulation has largely been derived from studies of highly expressed mRNAs. Telomerase is a key example of a protein that is ...
Zhao Ruibin R Department of Pediatrics, Zhongda Hospital, Southeast - - 2014
Ocular neovascularization is a vision-threatening complication of ischemic retinopathy that develops in various ocular disorders, such as retinopathy of prematurity (ROP) and diabetic retinopathy. Both Ang-2 and VEGF are implicated in this pathogenesis. However, their inter-regulation still remains elusive. Competitive endogenous RNAs (ceRNAs) are messenger RNA (mRNA) molecules that affect ...
Tan Sean Yang-Yi SY Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore 637551 School of Biological Sciences, Nanyang Technological University, Singapore - - 2014
Food is now recognized as a natural resource of novel antimicrobial agents including those that target the virulence mechanisms of bacterial pathogens. Iberin, an isothiocyanate compound from horseradish, was recently identified as a quorum sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa. Here, we used a comparative systems biology ...
Sasse Sarah K SK Department of Medicine, National Jewish Health, Denver, CO, - - 2014
Nuclear receptors (NRs) are widely targeted to treat a range of human diseases. Feed-forward loops are an ancient mechanism through which single cell organisms organize transcriptional programming and modulate gene expression dynamics, but they have not been systematically studied as a regulatory paradigm for NR-mediated transcriptional responses. Here, we provide ...
Kowalska Joanna J Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Warsaw, - - 2014
Modified mRNA cap analogs aid in the study of mRNA-related processes and may enable creation of novel therapeutic interventions. We report the synthesis and properties of 11 dinucleotide cap analogs bearing a single boranophosphate modification at either the α-, β- or γ-position of the 5',5'-triphosphate chain. The compounds can potentially ...
Rajasundaram Dhivyaa D Institute of Biochemistry and Biology, University of Potsdam, Potsdam-Golm, 14476, Germany Max-Planck Institute of Molecular Plant Physiology, Potsdam-Golm, 14476, - - 2014
A key challenge in biology is to systematically investigate and integrate the different levels of information available at the global and single-cell level. Recent studies have elucidated spatiotemporal expression patterns of root cell types in Arabidopsis thaliana, and genome-wide quantification of polysome-associated mRNA levels, i.e. the translatome, has also been ...
Liu W W Department of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, - - 2014
Bromodomain-containing protein 4 (BRD4) is an important epigenetic reader implicated in the pathogenesis of a number of different cancers and other diseases. Brd4-null mouse embryos die shortly after implantation and are compromised in their ability to maintain the inner cell mass, which gives rise to embryonic stem cells (ESCs). Here ...
Knake Claudia C Department of Physiology, Otago School of Medical Sciences, University of Otago, Lindo Ferguson Building, 270 Great King Street, Dunedin 9010, New - - 2014
Gout patients receiving a combination of allopurinol and furosemide require higher allopurinol doses to achieve the target serum urate (SU) of < 6mg/dl [1]. Our study aimed to identify the molecular basis for this observation. We used a fluorimetric assay to determine the impact of furosemide and oxypurinol (the active ...
Miranda P J PJ Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu, - - 2014
MicroRNAs (miRNAs) are small non coding RNA molecules (∼23nt) that are capable of regulating several physiological and pathological processes by targeting mRNAs post transcriptionally, and miRNAs are also known to be regulated by their own target gene(s) in a feedback manner. In this study, we analysed the expression of miRNAs ...
Ascenso Andreia - - 2014
Background & Scope of the review: This review focuses on the UV radiation effects on skin, emphasizing the photoaging process, and the photoprotection conferred by tretinoin (all-trans retinoic acid or ATRA). Tretinoin is still the best tested retinoid to reverse photoaged skin. Major Conclusions: Tretinoin can be used for photoaging ...
Zhou Joseph Yi JY Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0G4, - - 2014
The recent discovery of microRNA, thousands of short, non-coding strands of RNA, that regulate gene expressions on the transcriptional level throughout the body, raises the possibility of their roles as therapeutic targets in the treatment of a diverse range of diseases including diabetes, cancer, cardiovascular disease, and obesity. Specifically, their ...
Martínez Luary C LC Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México. Cuernavaca, Morelos 62210, - - 2014
Salmonella Pathogenicity Islands 1 and 2 (SPI-1 and SPI-2) have essential roles in the pathogenesis of Salmonella enterica. Previously, we reported transcriptional cross-talk between SPI-1 and SPI-2, where the SPI-1 regulator HilD induces expression of the SsrA/B two-component system, the central positive regulator of SPI-2, when Salmonella is grown to ...
Zhang Lin L Department of Gastroenterology and Hepatology, Jinshan Hospital of Fudan University, 1508, Longhang road, 201508 Shanghai, - - 2014
Evidence of an association between inflammation, microRNAs (miRNAs) and tumorigenesis has emerged in recent years. Patients with inflammatory bowel disease (IBD) are at an increased risk for colorectal cancer (CRC) development, suggesting that inflammatory mediators play a causative role in colon carcinogenesis. MiRNAs are small (19-22 nucleotides) non-coding RNA molecules ...
Lind Monique M Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, Ludwig-Maximilians University Munich, Oberschleissheim, - - 2014
The distal compartments of the udder are the first to interact with invading pathogens. The regulatory and effector functions of two major teat regions [Fürstenberg's rosette (FR); teat cistern (TC)] are largely unknown. The objective of this study was to establish an in vitro model with explants of the FR and ...
Wang Jingli J Auckland Cancer Society Research Centre, Private Bag 92019, The University of Auckland, Auckland, New - - 2014
SN30000 is a second-generation benzotriazine-N-oxide hypoxia-activated prodrug scheduled for clinical trial. Previously we showed that covalent binding of the hypoxia probe EF5 predicts metabolic activation of SN30000 in a panel of cancer cell lines under anoxia, suggesting that they are activated by the same reductases. However the identity of these ...
Saksi Jani J Research Programs Unit, Molecular Neurology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland - - 2014
-Fatty acid-binding protein 4 (FABP4 or aP2 in mice) has been identified as a key regulator of core aspects of cardiometabolic disorders including lipotoxic endoplasmic reticulum (ER) stress in macrophages. A functional promoter polymorphism (rs77878271) of human FABP4 gene has been described resulting in reduced FABP4 transcription. -We investigated the ...
Doron Lior L Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, - - 2014
The expression of the CO2 -fixation enzyme ribulose-bisphosphate carboxylase/oxygenase (Rubisco), which is affected by light, involves the cysteine-rich protein, bundle-sheath defective-2 (BSD2) that was originally identified in maize bundle-sheath cells. We identified the BSD2 orthologue in Chlamydomonas reinhardtii as a small protein (17 kDa) that is localized to the chloroplast. ...
Kao Cheng-Yen CY Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, - - 2014
Motility mediated by the flagella of Helicobacter pylori has been shown to be required for normal colonization and is thought to be important for the bacteria to move toward the gastric mucus in niches adjacent to the epithelium. Barnard et al. showed that CsrA appears to be necessary for full motility ...
Shi Jia-Xin JX Department of Respiratory Medicine, Lianyungang First People's Hospital, Affiliated Hospital of Xuzhou Medical College, Clinical Medical School of Nanjing Medical University, Lianyungang 222002, China. Electronic address: - - 2014
Glucocorticoids have been widely used in various inflammatory disorders, and the transcriptional repression of inflammatory mediators has been considered to be the main mechanism of action. However, a previous study showed that dexamethasone inhibited interleukin 8 (IL-8) expression by promoting IL-8 mRNA decay, which implies a posttranscriptional regulation. Nevertheless, by ...
Zhao Ya Y Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, - - 2014
Numerous studies have established important roles for microRNAs (miRNAs) in regulating gene expression. Here, we report that miRNAs also serve as a surveillance system to repress the expression of nonsense mRNAs that may produce harmful truncated proteins. Upon recognition of the premature termination codon by the translating ribosome, the downstream ...
Liu Bo B Department of Pharmacology and Systems Therapeutics, Box - - 2014
Messenger RNA decay in Bacillus subtilis is accomplished by a combination of exoribonucleases and endoribonucleases. Intermediates in the decay process have not been readily detectable, and previous studies on mRNA decay have used a handful of highly expressed transcripts as models. Here, we use RNA-Seq analysis to probe mRNA turnover ...
Zhao Xia X Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, - - 2014
Activation of RhoA, a low molecular-weight G-protein, plays an important role in protecting the heart against ischemic stress. Studies using non-cardiac cells demonstrate that the expression and subsequent secretion of the matricellular protein CCN1 is induced by GPCR agonists that activate RhoA. In this study we determined whether and how ...
Köster Tino T Molecular Cell Physiology, Bielefeld - - 2014
The hnRNP-like glycine-rich RNA-binding protein AtGRP7 regulates pre-mRNA splicing in Arabidopsis. Here we used small RNA-seq to show that AtGRP7 also affects the miRNA inventory. AtGRP7 overexpression caused a significant reduction in the level of 30 miRNAs and an increase for 14 miRNAs with a minimum log2 fold change of ...
Liu Bo B FIRST, Aihara Innovative Mathematical Modelling Project, Japan Science and Technology Agency, Tokyo, Japan Institute of Industrial Science, The University of Tokyo, Tokyo, Japan Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China, Xidian University, Xi'an, People's Republic of - - 2014
Gene transcription is a noisy process carried out by the transcription machinery recruited to the promoter. Noise reduction is a fundamental requirement for reliable transcriptional responses which in turn are crucial for signal transduction. Compared with the relatively simple transcription initiation in prokaryotes, eukaryotic transcription is more complex partially owing ...
Sumi Daigo D Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, - - 2014
Arsenic-induced toxicity appears to be dependent on the tissue- or cell-specific accumulation of this metalloid. An early study showed that arsenic was retained in the esophagus as well as the liver, kidney cortex and skin of marmosets after intraperitoneal administration of (74)As-arsenite. However, there is little available information regarding the ...
Ba Liang-Jie LJ State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, 510642, - - 2014
The ripening-induced MaBSD1 acts as a transcriptional activator, and might be involved in banana fruit ripening partly through directly activating the expression of two ripening-associated genes, MaEXP1/2. BSD (BTF2-like transcription factors, synapse-associated proteins and DOS2-like proteins) transcription factors are characterized by a typical BSD domain. However, little information is available ...
Chinenov Yurii - - 2014
Inflammation triggered by infection or injury is tightly controlled by glucocorticoid hormones which signal via a dedicated transcription factor, the Glucocorticoid Receptor (GR), to regulate hundreds of genes. However, the hierarchy of transcriptional responses to GR activation and the molecular basis of their oftentimes non-linear dynamics are not understood. We ...
Bianchi A A UMR 7365 CNRS-Université de Lorraine « Ingénierie Moléculaire et Physiopathologie Articulaire » (IMoPA), Biopôle de l'Université de Lorraine, Campus Biologie-Santé, Vandœuvre-lès-Nancy, France. Electronic address: - - 2014
The inhibitory effect of 15-deoxy-Δ(12, 14)-prostaglandin J2 (15d-PGJ2) on pro-inflammatory genes expression has been extensively documented and frequently ascribed to its ability to prevent NF-κB pathway activation. We and others have previously demonstrated that it was frequently independent of the peroxisome proliferator activated receptor (PPAR)γ activation. Here, we provide evidence ...
Kim Samin S Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH - - 2014
High-throughput RNA-sequencing technology has identified the 5' UTR region of sarA to contain two putative small RNAs, designated teg49and teg48. Northern blot analysis disclosed that teg49 and teg48 were detectable within the P3-P1 and P1 sarA promoter region, respectively. Focusing on teg49, we found that this small RNA, consisting of ...
Tan Shuwen S College of Life Science, Foshan University, No. 1 Xianhu University Road, Nanhai, Foshan, Guangdong 528231, China; Holdone Aquaculture Breeding Limited Company, Foshan, Guangdong 528231, - - 2014
To gain more knowledge about the physiological regulation of metal pollutant detoxification in grass carp, we examined Cd concentration and its the potential influence on the expression of metallothionein 2 (MT2) and multidrug resistance protein 2 (ABCC2) mRNA in the liver and kidney, using in vitro and in vivo experiments. ...
Choi Sung-Chan SC Department of Environmental Sciences and Biotechnology, Hallym University, Chunchon, 200-702, Republic of - - 2014
4-Hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF), a nonhalogenated furanone found in a variety of fruits, has been shown to have antimicrobial activity. However, few studies have focused on its inhibitory effect on bacterial quorum sensing (QS) at levels below the non-inhibitory concentration. In this study, 0.1 μM HDMF decreased the production of QS signal ...
Yauk Yar-Khing YK The New Zealand Institute for Plant & Food Research Limited (PFR), Private Bag 92169, Auckland, 1142, New - - 2014
Glycosides are an important potential source of aroma and flavour compounds for release as volatiles in flowers and fruit. The production of glycosides is catalysed by UDP-glycosyltransferases (UGTs) that mediate the transfer of an activated nucleotide sugar to acceptor aglycones. A screen of UGTs expressed in kiwifruit (Actinidia deliciosa) identified ...
Anwar-Mohamed Anwar A Faculty of Pharmacy and Pharmaceutical Sciences, 2142J Katz Group-Rexall Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB T6G 2E1, - - 2014
The toxic effects of arsenic on the whole brain, as well as the discrete regions, has been previously reported for mice. We investigated the effects of acute arsenite (As(III)) on brain levels of arachidonic acid (AA) and its associated metabolites generated through cytochrome P450 (CYP), cyclooxygenase (COX), and lipoxygenase (LOX) ...
Umasuthan Navaneethaiyer N Department of Marine Life Sciences, School of Marine Biomedical Sciences, Jeju National University, Jeju Self-Governing Province 690-756, Republic of Korea; Fish Vaccine Development Center, Jeju National University, Jeju Self-Governing Province 690-756, Republic of - - 2014
Superoxide dismutases (SODs) are dedicated to scavenge and dismutate the superoxide anions in order to protect the cells from oxidative stress by establishing the redox homeostasis. In this study, we describe a cytosolic Cu/ZnSOD, the second SOD member from rock bream Oplegnathus fasciatus (Of-cCu/ZnSOD) at molecular, genomic structural-, transcriptional- and ...
Johnson Michael G MG Department of Medicine, Division of Endocrinology University of Wisconsin , Madison, WI , USA - - 2014
Abstract Introduction: Endothelin (ET1) promotes the growth of osteoblastic breast and prostate cancer metastases. Conversion of big ET1 to mature ET1, catalyzed primarily by endothelin converting enzyme 1 (ECE1), is necessary for ET1's biological activity. We previously identified the Ece1, locus as a positional candidate gene for a pleiotropic quantitative ...
Abed Nadia N INRA, UMR1282 Infectiologie et Santé Publique, F-37380 Nouzilly, France; Université François Rabelais de Tours, UMR1282 Infectiologie et Santé Publique, F-37000 Tours, - - 2014
One important step for the pathogenesis of Salmonella is its ability to penetrate host cells. Recently, a new entry system involving the outer membrane protein Rck has been characterized. Previous studies have shown that the pefI-srgC locus, which contains rck, was regulated by the temperature and SdiA, the transcriptional regulator ...
Lin Grace G Cellular & Molecular Biology Program, Univ Michigan, Ann Arbor, MI; Department of Molecular & Integrative Physiology, Univ Michigan, Ann Arbor, - - 2014
Expression of the Growth Hormone (GH)-stimulated gene Socs2 (Suppressor Of Cytokine Signaling 2) is mediated by the transcription activator STAT5 (Signal Transducer and Activator of Transcription 5) and the transcription repressor BCL6 (B-cell lymphoma 6). ChIP-Sequencing identified Cish (Cytokine-inducible SH2-containing protein) and Bcl6 as having similar patterns of reciprocal occupancy ...
El-Mowafy Somaia A SA Department of Microbiology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: - - 2014
Quorum sensing (QS) plays a vital role in regulation of virulence factors and toxins in Pseudomonas aeruginosa, which can cause serious human infections. Therefore, the QS system in P. aeruginosa may be an important target for pharmacological intervention. Activity of aspirin on the QS system was assessed using a reporter ...
Tran-Lundmark Karin K Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, - - 2014
Smooth muscle cell (SMC) proliferation is a key process in stabilization of atherosclerotic plaques, and during restenosis after interventions. A clearer understanding of SMC growth regulation is therefore needed to design specific anti-proliferative therapies. Retinoic acid has been shown to inhibit proliferation of SMCs both in vitro and in vivo ...
Farrokhnia Farkhondeh F University of Manchester, United - - 2014
Placental cell growth depends on an adaptable combination of an endogenous developmental programme and the exogenous influence of maternal growth factors, both of which may be influenced by microRNA (miR)-dependent effects on gene expression. We have previously shown that global miR suppression in placenta accelerates proliferation and enhances levels of ...
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