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Guo Zhentao Z Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, - - 2014
Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a tumor suppressor gene and may be related to tumor drug resistance. In this study, we explored whether LRIG1 protein expression can ...
Sung Hye Youn HY Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, - - 2014
Recent discoveries suggest that aberrant DNA methylation provides cancer cells with advanced metastatic properties. However, the precise regulatory mechanisms controlling metastasis genes and their role in metastatic transformation are largely unknown. To address epigenetically-regulated gene products involved in ovarian cancer metastasis, we examined the mechanisms regulating mucin 13 (MUC13) expression ...
Sheng Xiu-Jie XJ Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. - - 2014
Metastasis-associated in colon cancer 1 (MACC1) is a newly identified gene that has been shown to promote tumor cell invasion and metastasis. The present study investigated the effect of MACC1 downregulation on the biological characteristics of the ovarian cancer OVCAR3 cell line. In this study, MACC1 expression was blocked using ...
Yang Jia-Jun JJ Department of Neurology, Sixth People's Hospital of Shanghai Jiao Tong University, Shanghai 200233, P.R. - - 2014
The aim of this study was to investigate the effects of pentylenetetrazol (PTZ) and nuclear factor κ B (NF-κB) decoy oligodeoxynucleotides (ODNs) on p38 expression in neuron-like PC12 cells. In addition, the role of NF-κB activation in the pathogenesis of epilepsy was explored. p38 expression levels in control and PTZ-treated ...
Qiu Guoqiang G Laboratory of Hematology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu 213003, P.R. - - 2014
The present study examined the effects of simvastatin on the proliferation, apoptosis and gene expression levels involved in the nuclear factor-κB (NF-κB) signaling pathway in the human acute promyelocytic leukemia NB4 cell line by methyl thiazolyl tetrazolium assay, flow cytometry and the Human NF-κB Signaling Pathway RT(2) Profiler™ PCR Array ...
Peng Tian-Shu TS Department of Anorectal Disease, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410005, P.R. - - 2014
Protein phosphatase, Mg(2+)/Mn(2+) dependent, 1D (PPM1D) has been associated with carcinogenesis. The present study investigated PPM1D expression as a potential biomarker in colorectal cancer (CRC). PPM1D expression was assessed using immunohistochemistry in 368 patients with CRC. The correlation between PPM1D expression, clinicopathological features and prognosis was analyzed. PPM1D small interfering ...
Xiao Hui H Department of Laboratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, P.R. - - 2014
c-Kit and epidermal growth factor receptor (EGFR) have critical roles in cell proliferation and differentiation in patients with non-small cell lung cancer (NSCLC). The present study aimed to investigate the prognostic impact of c-Kit and/or EGFR expression in tumor tissue samples from 146 patients with NSCLC. c-Kit expression was analyzed ...
Qin Hui H Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China, - - 2014
Alpha B-crystallin (CRYAB) is one of the principal members of the small heat-shock protein family, and several studies described the CRYAB expression in human cancers. However, the association between CRYAB expression and the clinical features of non-small cell lung cancer (NSCLC) is rarely elucidated. In this present study, one-step quantitative ...
Zhang CaiYun C College of Livestock Husbandry and Veterinary Engineering, Henan Agricultural University, Henan Research Center of Breeding Resources for Poultry, Zhengzhou 450002, People's Republic of China., College of Biology Engineering, Henan University of Technology, Zhengzhou 450001, People's Republic of - - 2014
Objective-To determine the effects of resveratrol (RES) on growth and immune status in chickens receiving conventional vaccinations. Animals-Two hundred forty 1-day-old layer chickens. Procedures-Chickens received conventional vaccinations throughout the study and were randomly assigned to 1 of 4 treatments in 6 replicate pens/treatment. Treatments included 1 control group (basal diet) ...
Li Wenfeng W Department of Radiation Oncology, First Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325000, Zhejiang, China, - - 2014
Enhanced glycolysis is a common trait of many types of human cancers. This study was to detect the expression pattern of three regulatory enzymes during glycolysis in esophageal squamous cell carcinoma (ESCC) and to investigate their correlation with patients' outcome based on banked pathology material. A total of 141 surgically ...
Li Ruixin R Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Xiangya Road, Changsha, 410008, Hunan, People's Republic of - - 2014
Aberrant expression of microRNAs (miRNAs) has been shown to play important roles in cancer progression as a result of changes in expression of their target genes. In this study, we investigated the roles of miR-520d-3p on gastric cancer (GC) cell proliferation, migration, and invasion, and confirmed that this miRNA regulates ...
Kao Ting-Hsien TH Graduate Institute of Medical Science, National Defense Medical Center, - - 2014
Object Increased neurotrophin activity in degenerative intervertebral discs (IVDs) is one potential cause of chronic low-back pain (LBP). The aim of the study was to assess if nerve growth factor (NGF) might alter gene expression of IVD cells and contribute to disc degeneration by enhancing expression or activity of factors ...
Isogaya Kazunobu K Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, - - 2014
Thyroid transcription factor-1 (TTF-1, also known as NKX2-1) is a tissue-specific transcription factor in lung epithelial cells. Although TTF-1 inhibits the epithelial-to-mesenchymal transition induced by transforming growth factor-β (TGF-β) in lung adenocarcinoma cells, the mechanism through which TTF-1 inhibits the functions of TGF-β is unknown. Here we show that TTF-1 ...
Sun G G GG Department of Chemoradiotherapy, Tangshan people's hospital, NO.65, Shengli road, Lunan district, Tangshan, 063000, Hebei province, - - 2014
This study aimed to analyze the expression, clinical significance of proto-oncogene in nasopharyngeal carcinoma and the biological effect in its cell line by siRNA targeting wild-type p53-induced phosphatase 1 (Wip1). Immunohistochemistry and western blot were respectively used to analyze Wip1 protein expression in 85 cases of nasopharyngeal cancer and normal ...
Young George R - - 2014
A substantial proportion of both the mouse and human genomes comprise of endogenous retroelements (REs), which include endogenous retroviruses. Over evolutionary time, REs accumulate inactivating mutations or deletions and thus lose the ability to replicate. Additionally, REs can be transcriptionally repressed by dedicated mechanisms of the host. Nevertheless, many of ...
Yan Yang Y Department of Urology, Shanghai Tenth People's Hospital, Tongji University, No 301, Yanchang Mid-Road, Shanghai, 200072, - - 2014
Flotillin-2 (FLOT2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathway. FLOT2 has recently been identified to be involved in tumorigenesis of several cancers such as breast cancer, melanoma, and gastric cancer. However, the role of FLOT2 in renal ...
Zara Susi S Section of Human Anatomy, Department of Pharmacy, University "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy, - - 2014
This study aimed to check the effect of zoledronic acid (ZA) at subtoxic dose on human osteoblasts (HOs) in terms of cell viability, apoptosis occurrence, and differentiation induction. ZA belongs to the family of bisphosphonates (BPs), largely used in the clinical practice for the treatment of bone diseases, often associated ...
Czubowicz Kinga K Laboratory of Preclinical Research and Environmental Agents, Department of Neurosurgery, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego Street, 02-106, Warsaw, - - 2014
Sphingosine kinase-1 (Sphk1-1, EC 2.7.1.91) is a regulator of pro-survival signalling, and its alterations have been observed in Alzheimer's disease, brain ischemia and other neurological disorders. In this study we addressed the question whether Sphk1 and its product, sphingosine-1-phosphate (S1P), play a significant role in glucose deprivation (GD)/glucose reload (GR) ...
Silveyra Patricia P 1Center for Host Defense, Inflammation, and Lung Disease (CHILD) Research, Department of Pediatrics, The Pennsylvania State University College of Medicine , Hershey, Pennsylvania , - - 2014
ABSTRACT Human surfactant protein A (SP-A) plays an important role in surfactant metabolism and lung innate immunity. SP-A is synthesized and secreted by alveolar type II (ATII) cells, one of the two cell types of the distal lung epithelium (ATII and ATI). We have shown that miRNA interactions with sequence ...
Mustafa Shamimunisa B SB 1Department of Pediatrics, University of Texas Health Science Center , San Antonio Texas , - - 2014
ABSTRACT During fetal development physiological stretching helps drive lung growth and maturation. At birth, the α-subunit of the alveolar epithelial sodium channel (α-ENaC) is a critical factor in helping to facilitate clearance of lung fluid during the perinatal period. The effects of stretch, however, on α-ENaC expression in the fetal ...
Kawase Satoshi S Keio University School of Medicine, Physiology, Tokyo, Japan ; - - 2014
The transcriptional regulation of neural stem/progenitor cells (NS/PCs) is of great interest in neural development and stem cell biology. The RNA-binding protein Musashi1 (Msi1), which is often employed as a marker for NS/PCs, regulates Notch signaling to maintain NS/PCs in undifferentiated states by the translational repression of Numb expression. Considering ...
Chiappara Giuseppina G 1Istituto di Biomedicina e Immunologia Molecolare (I.B.I.M.), Commessa di Immunopatologia e Farmacologia Sperimentale dell'Apparato Respiratorio, Consiglio Nazionale delle Ricerche , Palermo , - - 2014
ABSTRACT Background: The cyclin-dependent kinase inhibitor p21CIP1/WAF1 is involved in cell-cycle growth arrest due to cell stressors, such as cigarette smoke. The role of p21 in cell apoptosis is controversial as it exerts pro- or antiapoptotic effects in different cells. In the present study, we investigated whether, in the epithelium ...
Mao Jie J Department of Neurosurgery of The first affiliated Hospital, Wannan Medical College, 2 West Zheshan Road, Wuhu, 241001, Anhui, People's Republic of - - 2014
Ezrin is overexpressed in a variety of neoplastic cells and involved in the later stages of tumor progression and metastasis. Ezrin expression can be regulated at both the transcriptional and post-transcriptional levels. We used a combination of bioinformatics and experimental techniques to demonstrate that the miR-204 is a direct negative ...
Weiss Michele B MB Department of Cancer Biology and Kimmel Cancer Center, Thomas Jefferson - - 2014
The neural crest is a multi-potent, highly migratory cell population that gives rise to diverse cell types, including melanocytes. Factors regulating the development of the neural crest and emigration of its cells are likely to influence melanoma metastasis. The transcription factor FOXD3 plays an essential role in pre-migratory neural crest ...
Farberov Svetlana - - 2014
Previously we showed luteal stage-specific regulation of angiogenesis modulating factors by prostaglandin F2 alpha (PGF2a). Fibroblast growth factor 2 (FGF2) and thrombospondins (THBSs) exhibited the most divergent profile of induction by PGF2a. We therefore examined the transcriptional regulation and roles of THBSs in luteal cells and studied their interaction with ...
Miyata Kohei K Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Department of Biochemistry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan; Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, - - 2014
Ovarian clear cell carcinoma (OCCC) is a worst histological subtype than other ovarian malignant tumor. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for ovarian cancer therapy. The aims of this study were to validate the efficacy of HB-EGF-targeted therapy for OCCC and to identify the transcription ...
Alizadeh Effat E Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, - - 2014
MicroRNAs are small non-coding RNAs that regulate key processes of the stem cells. Although, microRNAs have emerged as powerful regulators of differentiation; few studies have been focused on the post transcriptional regulation of hepatic differentiation in mesenchymal stem cells (MSCs) by microRNAs. The aim of the present study was to ...
Liu Jiannan J Department of Oral Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, - - 2014
Kallmann syndrome 1 sequence gene (KAL1) protein is an extracellular matrix associated protein which plays vital roles in neurons development and cell migration. However, its biological functions and clinical implications have yet not been revealed in oral carcinogenesis. The objective of the study was to evaluate the role of KAL1 ...
Yan Guangyao G Jiangsu Livestock Embryo Engineering Laboratory, Nanjing Agricultural University, Nanjing, 210095, - - 2014
The plasticity of human and murine bone marrow mesenchymal stem cells (BMSCs) has been proven by their ability to trans-differentiate to multilineage cells, including germ cells. We have investigated ability of goat BMSCs to trans-differentiate to germ cells with extrinsic (e.g., retinoic acid [RA] and BMP4 signalling molecules) and intrinsic ...
Maccani Andreas A Austrian Centre of Industrial Biotechnology (ACIB GmbH), Muthgasse 11, 1190, Vienna, Austria, - - 2014
MicroRNAs are short non-coding RNAs that play an important role in the regulation of gene expression. Hence, microRNAs are considered as potential targets for engineering of Chinese hamster ovary (CHO) cells to improve recombinant protein production. Here, we analyzed and compared the microRNA expression patterns of high, low, and non-producing ...
Zhou Yuning Y †Markey Cancer Center, The University of Kentucky, Lexington, - - 2014
The intestinal mucosa undergoes a continual process of proliferation, differentiation and apoptosis, which is regulated by multiple signaling pathways. Previously, we have shown that the nuclear factor of activated T-cells 5 (NFAT5) is involved in the regulation of intestinal enterocyte differentiation. Here, we show that treatment with sodium chloride (NaCl), ...
Pioli Peter D PD Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT - - 2014
The protein Zfp318 is expressed during the transition of naive B cells from an immature to mature state. To evaluate its role in mature B cell functions, a conditional gene deficiency in Zfp318 was created and deleted in bone marrow lineages via Vav-Cre. B cell development was minimally altered in ...
Lai Wei-An WA W Lai, Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei , - - 2014
Estrogens are essential for female reproduction and overall well-being, and estrogens in circulation are largely synthesized in ovarian granulosa cells. Using primary culture of ovarian granulosa cells from gonadotropin-primed immature rats, we recently uncovered that pituitary FSH and ovarian cytokine TGFβ1 induce calcineurin-mediated dephosphorylation-activation of CREB-regulated transcription coactivator (CRTC2) to ...
Zhang Qi Q Q Zhang, The First Clinical College, Lanzhou University, LanZhou, - - 2014
Non-alcoholic fatty liver disease (NAFLD) is associated with hepatic microangiopathy and liver inflammation caused by type 2 diabetes mellitus (T2DM). Oxidised low-density lipoprotein (oxLDL) is involved in proinflammatory and cytotoxic events in various microcirculatory systems. The lectin-like oxLDL receptor-1 (LOX-1) plays a crucial role in oxLDL induced pathological transformation. However, ...
Kim Sung-Ho SH Department of Respiration, Tianjin First Central Hospital, Tianjin 300192, China - - 2014
Asthma is a common chronic inflammatory disease characterized by the infiltration and accumulation of memory-like Th2 cells and eosinophils. Viral infection has emerged as the most common cause of severe episodes of asthma. For the treatment of bronchial asthma, the root of liquorice (Glycyrrhiza glabra) has been used as a ...
Withers Ryan R School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, - - 2014
Acinetobacter species are widely distributed bacteria in the environment, and have recently gained notoriety as opportunistic nosocomial pathogens. Here we characterize a novel RNA polymerase-interacting protein named acidic transcription factor A, AtfA. It is small and highly acidic, and is widely distributed throughout the γ proteobacteria, including other significant pathogens ...
Zhao Jing J 1 Department of Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University , Shanghai, China - - 2014
The hepatitis B viral X protein (HBx) has been established to implicate in the development of HBV-related hepatocellular carcinoma (HCC) via multiple pathways. The oncoprotein astrocyte elevated gene-1 (AEG-1) is overexpressed in various tumors, including HCC, and plays critical roles in promoting cell migration and invasion. However, the mechanisms for ...
Rui Mingzhong M Department of Hematology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. - - 2014
Rosiglitazone (RGZ) is a thiazolidinedione ligand of peroxisome proliferator‑activated receptor‑γ. Our previous studies have confirmed that RGZ possesses antitumoral properties. Bone marrow angiogenesis exhibits an important role in multiple myeloma (MM), and angiogenesis often correlates with the prognosis and disease burden of MM. However, to the best of our knowledge, ...
Li Chuan-You CY Department of Brain Surgery, Xinxiang Center Hospital, Xinxiang, Henan 453000, P.R. - - 2014
Glioma is the most common brain malignancy and has a very poor prognosis. The current treatment options have a minimal benefit on prolonging patient survival time. Accumulating data have shown that the WNT signaling pathway has a critical function in the progression and invasion of glioma. Thus, targeting WNT signaling ...
Zhang Xiaoning X Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunity, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong, 250012, P.R. - - 2014
Recent data reported the increased expression of forkhead box protein 3 (FOXP3), the well known master regulator of CD4(+) C25(+) regulatory T cells, in hepatocellular carcinoma (HCC) cells. However, the mechanisms remain unknown. We previously showed that preS2, one of important regulatory proteins encoded by HBV, triggers transactivation of hTERT ...
Huo Xiaodong X Sichuan University, - - 2014
Glycogen synthase kinase-3 (GSK3) has either tumor suppressive roles or pro-tumor roles in different types of human tumors. A number of GSK3 targets in diverse signaling pathways have been uncovered, such as tuberous sclerosis complex subunit 2 and β-catenin. The O subfamily of forkhead/winged helix transcription factors (FOXO) are known ...
Bouguen Guillaume G Université Lille Nord de France, Lille, France Inserm U995, Lille, France Service des Maladies de l'Appareil digestif, University Hospital of Rennes, Pontchaillou, France Inserm, UMR991, Liver Metabolism and Cancer, Rennes, France Université de Rennes 1, Rennes, - - 2014
Immune tolerance breakdown during UC involves the peroxisome proliferator-activated receptor-γ (PPARγ), a key factor in mucosal homoeostasis and the therapeutic target of 5-aminosalycilates, which expression is impaired during UC. Here we assess the impact of glucocorticoids (GCs) on PPARγ expression, focusing especially on extra-adrenal cortisol production by colonic epithelial cells ...
Kim Mi-Bo MB Department of Biomaterials Science and Engineering, Yonsei University, Seoul 120-749, Republic of - - 2014
Kirenol has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities; however, its effect on osteoblast differentiation has not yet been reported. The aim of the present study was to evaluate the effect of kirenol on osteoblast differentiation through activation of the bone morphogenetic protein (BMP) and Wnt/β-catenin ...
Wang Xin X Department of Orthopedic Surgery and the Graduate Program in Cell and Developmental Biology, Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Bone and Soft Tissue, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, - - 2014
Matrix metalloproteinase-3 (MMP-3) plays an important role in intervertebral disc degeneration, a ubiquitous condition closely linked to low back pain and disability. Elevated expression of syndecan 4, a cell surface heparan sulfate proteoglycan, actively controls disc matrix catabolism. However, the relationship between MMP-3 expression and syndecan 4 in the context ...
Schaefer Jeremy S JS Department of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX 77054, - - 2014
Roquin-1, a RING finger E3 ubiquitin ligase, functions as a modulator of inflammation; however, nothing is known about how Rc3h1 expression is regulated. Here, we describe an opposing relationship between Roquin-1 and the IL-17 proinflammatory cytokine by demonstrating that enforced expression of Rc3h1 restricts Il17a expression, and that exposure of ...
Yu Guiping G Department of Cardiothoracic Surgery, The Affiliated Jiangyin Hospital of Southeast University Medical College, No. 163, Shoushan Rd, Jiangyin, 214400, - - 2014
The aim of this study was to determine the relationship and underlying mechanisms between ectopic expression of phosphatidylethanolamine-binding protein 4 (PEBP4) and cisplatin (DDP)-induced cytotoxicity in the lung cancer cell line A549 to provide an experimental basis for future chemotherapeutic applications involving PEBP4 in human lung cancer. A recombinant plasmid, ...
Fernández-Pérez Antonio - - 2014
Alterations in transcription factors expressed in insulin-producing islet β cells generate pancreatic dysfunction leading to diabetes. The homeodomain transcription factor Alx3 expressed in pancreatic islets participates in the regulated expression of several islet genes, and its deficiency in mice leads to islet cell apoptosis and glucose intolerance. In this study, ...
Yan Hong H State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, - - 2014
Aim:Expression of liver low-density lipoprotein receptor (LDLR), a determinant regulator in cholesterol homeostasis, is tightly controlled at multiple levels. The aim of this study was to examine whether proteasome inhibition could affect LDLR expression and LDL uptake in liver cells in vitro.Methods:HepG2 cells were examined. Real-time PCR and Western blot ...
Ho P W M PW St. Vincent's Institute of Medical Research and Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, - - 2014
Osteosarcoma (OS) is the most common cancer of bone. Parathyroid hormone (PTH) regulates calcium homeostasis and bone development, while the paracrine/autocrine PTH-related protein (PTHrP) has central roles in endochondral bone formation and bone remodeling. Using a murine OS model, we found that OS cells express PTHrP and the common PTH/PTHrP ...
Cornett Ashley L AL Department of Biochemistry and Molecular Biology, Rutgers, The State University of New Jersey, New Jersey Medical School and the Graduate School of Biomedical Sciences, Newark, New Jersey 07103, - - 2014
Prostaglandins are a class of molecules that mediate cellular inflammatory responses and control cell growth. The oxidative conversion of arachidonic acid to prostaglandin H2 is carried out by two isozymes of cyclooxygenase, COX-1 and COX-2. COX-1 is constitutively expressed, while COX-2 can be transiently induced by external stimuli, such as ...
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