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Aryal Binod B Vascular Biology and Therapeutics Program, Yale University School of Medicine, 10 Amistad Street, Amistad Research Building, Room 337C, New Haven, CT, 06510, - - 2014
Noncoding RNAs (ncRNAs) represent a class of RNA molecules that typically do not code for proteins. Emerging data suggest that ncRNAs play an important role in several physiological and pathological conditions such as cancer and cardiovascular diseases, including atherosclerosis. The best-characterized ncRNAs are the microRNAs which are small, approximately 22-nucleotide ...
Armenia Joshua J Division of Experimental Oncology 2, CRO, National Cancer Institute, Aviano, - - 2014
MicroRNAs (miRs) are a large class of small regulatory RNAs that function as nodes of signaling networks. This implicates that miRs expression has to be finely tuned, as observed during cell cycle progression. Here, using an expression profiling approach, we provide evidence that the CDK inhibitor p27Kip1 regulates miRs expression ...
Tan Zengqi - - 2014
Epithelial-to-mesenchymal transition (EMT) is an essential biological process that occurs in embryonic development, metastatic diseases, and cancer progression. Altered expression of glycans is known to be associated with cancer progression. No studies to date have presented global analysis of the precise variation of N-glycans in EMT. We describe here the ...
Kumar V V Department of Molecular Medicine, Sapienza University, Rome, - - 2014
Notch signaling deregulation is linked to the onset of several tumors including T cell acute lymphoblastic leukemia (T-ALL). Deregulated microRNA (miRNA) expression is also associated to several cancers, including leukemias. However, the transcriptional regulators of miRNAs as well as the relationships between Notch signaling and miRNA deregulation are poorly understood. ...
Spirin P V PV Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, - - 2014
The t(8;21)(q22;q22) rearrangement represents the most common chromosomal translocation in acute myeloid leukemia (AML). It results in a transcript encoding for the fusion protein AML1-ETO (AE) with transcription factor activity. AE is considered to be an attractive target for treating t(8;21) leukemia. However, AE expression alone is insufficient to cause ...
Omori Akiko A Department of Developmental Genetics (A.O., G.Y.), Institute of Advanced Medicine, Wakayama Medical University, Wakayama, 641-8509, Japan; Okazaki Institute for Integrative Bioscience (S.M., Y.O.), National Institute for Basic Biology, National Institutes of Natural Science, Okazaki, 444-8787, Japan; Department of Clinical Anatomy (M.H.), Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, 113-8591, Japan; Department of Oncologic Pathology (K.I.), and Nephro-Urologic Surgery and Andrology (Y.S.), Mie University Graduate School of Medicine, Tsu, Mie, 514-8507, Japan; Department of Animal Bioscience (H.O.), Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga, 526-0829, Japan; and Division of Reproductive Engineering (N.N.), Center for Animal Resources and Development (CARD), Kumamoto University, Kumamoto 860-0811, - - 2014
Prostate is a male sex accessory organ. The prostatic epithelia consist primarily of basal and luminal cells that differentiate from embryonic urogenital sinus epithelia. Prostate tumors are believed to originate in the basal and luminal cells. However, factors that promote normal epithelial differentiation have not been well elucidated, particularly for ...
Dmitrieva Natalia I NI Renal Cellular and Molecular Biology Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD - - 2014
Hypercoagulability increases risk of thrombi that cause cardiovascular events. Here we identify plasma sodium concentration as a factor that modulates blood coagulability by affecting the production of von Willebrand factor (vWF), a key initiator of the clotting cascade. We find that elevation of salt over a range from the lower ...
Tan Frederick E FE Howard Hughes Medical Institute and Division of Biology and Departments of Bioengineering and Applied Physics, California Institute of Technology, Pasadena, CA - - 2014
AU-rich element mRNA-binding proteins (AUBPs) are key regulators of development, but how they are controlled and what functional roles they play depends on cellular context. Here, we show that Brf1 (zfp36l1), an AUBP from the Zfp36 protein family, operates downstream of FGF/Erk MAP kinase signaling to regulate pluripotency and cell ...
Chevallet Mireille M Université Grenoble Alpes, LCBM, F-38054 Grenoble, - - 2014
The canonical transient receptor potential 6 (TRPC6) protein is a non-selective cation channel able to transport essential trace elements like iron (Fe) and zinc (Zn) through the plasma membrane. Its over-expression in HEK-293 cells causes an intracellular accumulation of Zn, indicating that it could be involved in Zn transport. This ...
Jutooru Indira I Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX - - 2014
Reactive oxygen species (ROS)-inducing anticancer agents such as phenethyl isothiocyanate (PEITC) activate stress pathways for killing cancer cells. Here we demonstrate that PEITC-induced ROS decreased expression of microRNA-27a (miR-27a)/miR-20a:miR-17-5p and induced miR-regulated ZBTB10/ZBTB4 and ZBTB34 transcriptional repressors which, in turn, downregulate specificity protein (Sp) transcription factors (TFs) Sp1, Sp3 and ...
Jeon Ji Hoon JH Seoul National University, Department of veterinary physiology, Seoul, Korea, Republic of ; - - 2014
We aimed to study the relationship between glucosamine and FoxO1/Notch in gluconeogenesis and maintenance of mouse embryonic stem cell (mESC) self-renewal. Glucosamine (GlcN) increased glucose production and gluconeogenic enzymes (G6Pase and PEPCK) expression. GlcN also increased the percentage of cells in S phase, the protein expression of cell cycle regulatory ...
Bergadà Laura L Pathology Group, Pathology and Molecular Genetics Department, Hospital Universitari Arnau de Vilanova, University of Lleida, and IRB-Lleida (Lleida Institute for Biomedical Research), Lleida, - - 2014
Vitamin D (VD) deficiency has been suggested as a risk factor for cancer. One recognized mechanism is that the low-serum 25-hydroxyvitamin D (25(OH)D) of VD deficiency reduces intratumoral 25(OH)D conversion to 1α,25-dihydroxyvitamin D (1,25D, the hormonal form of VD), compromising 1,25D-VD receptor (VDR) antitumoral actions. Reduced tumoral VDR and increased ...
Liu Feng F Division of Biological Sciences/CDB, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, - - 2014
Positive autoregulation is an effective mechanism for the long-term maintenance of a transcription factor's expression. This strategy is widely deployed in cell lineages, where the autoregulatory factor controls the activity of a battery of genes that constitute the differentiation program of a postmitotic cell type. In Drosophila, the Notch pathway ...
Tulley Shaun S State University of New York at Stony Brook, United - - 2014
The tumor invasive phenotype driven by seprase expression/activity has been widely examined in an array of malignant tumor cell types, however very little is known about the transcriptional regulation of this critical protease. Seprase (also named FAPα; APCE; DPP5) is expressed at high levels by stromal fibroblasts, endothelial, and tumor ...
Arvey Aaron A 1] Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. [2] Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. - - 2014
The transcription factor Foxp3 is indispensable for the ability of regulatory T cells (Treg cells) to suppress fatal inflammation. Here we characterized the role of Foxp3 in chromatin remodeling and the regulation of gene expression in actively suppressive Treg cells in an inflammatory setting. Although genome-wide occupancy of regulatory elements ...
Zheng Meihua M Department of Physiology, Xuzhou Medical College, #209 Tongshan Road, Xuzhou, 221004, Jiangsu, - - 2014
The present study was designed to investigate the effect of hydrogen sulfide on cellular senescence of human umbilical vascular endothelial cells (HUVECs CC-2517) and its underlying mechanism. The premature senescence-like phenotype HUVECs (the fourth passage) was induced by treatment with nicotinamide (NAM, an inhibitor of SIRT1, 5 mmol/L, 12 h). Cells were ...
Choi Jeong-Hae JH Department of Oral Anatomy, School of Dentistry, Yangsan Campus of Pusan National University, Beomeo-ri, Mulgeum-eup, Yangsan-si, Yangsan, Gyeongsangnam, 626-870, South - - 2014
The barrier system of the skin not only defends against antigens and harmful substances, but also hinders the permeation of medicines and cosmetics into the dermis. Several strategies have been developed to enhance the absorption ability of skin, including the use of chemicals and skin ablation devices. However, the cost ...
Zhang Xiaoping X School of Hanlin, Nanjing University of Chinese Medicine, Taizhou, 225300, - - 2014
Liver fibrosis represents a frequent event following chronic insult to trigger wound healing responses in the liver. Activation of hepatic stellate cells (HSCs) is a pivotal event during liver fibrogenesis. Compelling evidence indicates that renin-angiotensin system (RAS) takes part in the pathogenesis of liver fibrosis. Angiotensin II (Ang II), the ...
Daggett R N RN Department of Comprehensive Pathology, Tokyo Medical and Dental University, Tokyo, - - 2014
Mycosis fungoides (MF) classically presents from patch stage to plaque stage over a number of years and finally progresses to tumour stage with nodal or visceral involvement and the mechanism of progression remains incompletely elucidated. Whereas, chemokines and their receptors have been shown as clues for disease mechanisms, CXCL12 and ...
Sunagawa Masataka M Departments of Medicine, University of Pittsburgh School of Medicine, A 1217 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, - - 2014
The objectives of this study were to examine the expression of various cellular proteins within the urothelium (UT) and lamina propria (LP) following chronic bladder ischemia in the rat urinary bladder. Urinary bladders were removed from adult Sprague-Dawley rats 8 weeks after creation of bladder ischemia and from sham controls. Immunocytochemistry ...
Seok Hye-Yeon HY Department of Molecular Biology, Pusan National University, Busan, 609-735, - - 2014
HRE1α shows transcriptional activation activity in its C-terminal region via GCC box but not DRE/CRT and plays an important role in root development via root meristem cell division regulation. AtERF73/HRE1 protein, a member of the Arabidopsis AP2/ERF family, contains a conserved AP2/ERF DNA-binding domain. Here, we studied the molecular function ...
Gao Qing Q Key Laboratory of Pathology of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, - - 2014
Recent studies have shown that block wnt/β-catenin signaling pathway is integrant for cardiomyocytes differentiation from bone marrow mesenchymal stem cells (MSCs). By transducing the MSCs with lentivirus which contain β-catenin interference RNA, we screened out the non β-catenin expression clone. In the establishment of knockdown β-catenin in MSCs, we investigated ...
Chen Zhi-Hua ZH 1Second Affiliated Hospital of Zhejiang, University School of - - 2014
Autophagy plays a pivotal role in cellular homeostasis and adaptation to adverse environments, though the regulation of this process remains incompletely understood. We have recently observed that caveolin-1 (Cav-1), a major constituent of lipid rafts on plasma membrane, can regulate autophagy in cigarette smoking-induced injury of lung epithelium, whereas the ...
Gossan Nicole C NC Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, - - 2014
Post-translational modifications (such as ubiquitination) of clock proteins are critical in maintaining the precision and robustness of the evolutionarily conserved circadian clock. Ubiquitination of the core clock transcription factor BMAL1 (brain and muscle Arnt-like 1) has recently been reported. However, it remains unknown whether BMAL1 ubiquitination affects circadian pacemaking and ...
Beguelini Mateus R MR Department of Biology, UNESP - Univ Estadual Paulista, São José do Rio Preto, São Paulo 15054-000, Brazil. Electronic address: - - 2014
Despite the worldwide distribution and many unique reproductive adaptations that bats present, many aspects of their reproductive hormonal regulation have not been adequately studied, especially in species that presented patterns of total testicular regression. Thus, this study aimed to evaluate the testicular expression of 17β-HSD type 1, aromatase and ERα ...
Erdei Zsuzsa Z Institute of Molecular Pharmacology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, - - 2014
ATP-binding cassette (ABC) transporters have key roles in various physiological functions as well as providing chemical defense and stress tolerance in human tissues. In this study, we have examined the expression pattern of all ABC proteins in pluripotent human embryonic stem cells (hESCs) and in their differentiated progenies. We paid ...
Bandyopadhyay Sushobhana S Department of Biochemistry, University of Calcutta, INDIA, & Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, - - 2014
Progression into mitosis is a major point of regulation in Schizosaccharomyces pombe cell cycle and its proper control is essential for maintenance of genomic stability. Investigation of the G2/M progression event in S. pombe has revealed the existence of a complex regulatory process that is responsible for making the decision ...
van de Schootbrugge Chantal - - 2014
The presence of hypoxia in head and neck squamous cell carcinoma (HNSCC) is associated with therapeutic resistance and increased risk of metastasis formation. alphaB-crystallin (HspB5) is a small heat shock protein, which is also associated with metastasis formation in HNSCC. In this study, we investigated whether alphaB-crystallin protein expression is ...
Girke Georg G Department for Orthopaedic, Trauma and Reconstructive Surgery, Charité-University of Medicine, Campus Benjamin Franklin, Berlin, - - 2014
Inferior tendon healing can lead to scarring and tendinopathy. The role of complement in tendon healing is still unclear. The aim of this study was to understand tenocytes response to mechanical injury and whether complement is regulated by injury. Tenocytes were injured using an optimized automated scratch assay model. Using ...
Link Jason M JM Shriners Hospitals for Children Portland, 3101 SW Sam Jackson Park Road, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address: - - 2014
The MYC family of proteins play essential roles in embryonic development and in oncogenesis. Efforts over the past 30years to define the transcriptional activities of MYC and how MYC functions to promote proliferation have produced evolving models of MYC function. One picture that has emerged of MYC and its partner ...
Park Gyeongsin G Department of Pathology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea; Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, - - 2014
Indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme for the tryptophan catabolism that plays an important role in the induction of immune tolerance. It is induced in the colon and exerts its effects there, regulating T-cell proliferation and survival. To address the role of IDO in acute graft-versus-host disease (AGVHD) after ...
Suman Pankaj P Reproductive Cell Biology Laboratory, National Institute of Immunology, New Delhi, - - 2014
The aim of this study was to investigate the relative importance of STAT3 and ERK1/2 activation in leukaemia inhibitory factor (LIF)-mediated invasion of JEG-3 cells. Matrigel matrix-based invasion assay; Western blot; cDNA microarray; quantitative RT-PCR; gene silencing by siRNA. Leukaemia inhibitory factor treatment led to the activation of STAT3 and ...
Butler Lynn M LM Department of Medicine, Centre for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden; - - 2014
Anemia is a feature of CKD and a complication of renal transplantation, often caused by impaired production of erythropoietin. The kidney is a target organ for human cytomegalovirus (hCMV) in such patients, but it is not known whether hCMV effects erythropoietin production. We found that kidneys from patients with CKD ...
Wei Zhengkai Z College of Veterinary Medicine, Jilin University, Changchun 130062, Jilin - - 2014
Niacin is a precursor of coenzymes NAD and NADP and plays a critical role in electron transfer during the metabolic process. In addition to its nutrimental function, niacin has long been used for the treatment of lipid disorders and cardiovascular disease. However, the effect of niacin on Staphylococcus aureus (S. ...
Zhou Ying Y Institute of Orthopaedics, the First Affiliated Hospital of Chinese PLA General Hospital, No. 51 Fucheng Road, Beijing 100048, - - 2014
Osteoblast plays a pivotal role in bone metabolism and bone remodeling by mediating bone formation and regulating the activity of osteoclast. Clarifying the regulators and regulation mechanisms of osteogenic differentiation of mesenchymal stem cells (MSCs) and pre-osteoblasts will provide tremendous promise for bone repair and bone regeneration. RNF185 was identified ...
Kwak Young-Don YD Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida; Biomolecular Science Center, University of Central Florida, 4000 Central Florida Blvd. BMS building, Room 223, Orlando, Florida - - 2014
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases leading to dementia. Although cytotoxicity of amyloid β peptides has been intensively studied within pathophysiology of AD, the physiological function of amyloid precursor protein (APP) still remains unclarified. We have shown previously that secreted APPα (sAPPα) is associated with ...
Cai Liquan L Department of Urology, The University of Pittsburgh, 5200 Centre Avenue, Pittsburgh, PA - - 2014
The tumor suppressor EAF2 is regulated by androgen signaling and associated with prostate cancer. While EAF2 and its partner ELL have been shown to be members of protein complexes involved in RNA polymerase II transcriptional elongation, the biologic roles for EAF2 especially with regards to the development of cancer remains ...
Chalubinski Maciej M Dept. of Internal Diseases and Clinical Pharmacology, Laboratory of Tissue Immunopharmacology, Medical University of Lodz, Kniaziewicza 1/5, 91-347 Lodz, Poland. Electronic address: - - 2014
The intestinal epithelium is exposed to oxygenated cholesterol products present in foodstuffs. In vitro studies demonstrate the effect of oxysterols on cytokine release by intestinal cells cultured alone. However, physiologically, the response of the intestinal epithelium to external agents occurs in the presence of dendritic cells (DCs). The aim of ...
Chen Yongbing Y Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, - - 2014
The aims of this study were to investigate the expression of transforming growth factor-β1 (TGF-β1) and α-smooth muscle actin (α-SMA) in surgical resection specimens from nonsmall cell lung cancer (NSCLC) and to evaluate the prognostic significance of this gene expression in stromal fibroblasts for patients with clinical stage I-IIIA NSCLC. ...
Pan Y Q - - 2014
The inhibitor of growth 2 (ING2) is a member of ING family, involved in cell cycle regulation, DNA repair, apoptosis and senescence, and participating in chromatin remodeling and transcriptional regulation by histone modification. Recent researches suggest ING2 plays roles in carcinogenesis both as tumor suppressor gene and ongocene depending on tumor ...
Shoji Toru T Department of Biotechnology, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, - - 2014
Interleukin-10 (IL-10) expression was significantly elevated upon stimulation with lipopolysaccharide (LPS) when the sialic acid-recognizing Ig-superfamily lectin Siglec-5 or -9 was overexpressed in RAW264 cells. During the course to clarify the mechanism for this activation, we found that IL-10 promoter proximal region up to -500 bp led to transactivation similar to ...
Njaine Brian B Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, Edifício do Centro de Ciencias da Saude, Bloco G, Cidade Universitaria, Ilha do Fundão, 21941-902, Rio de Janeiro, - - 2014
We showed previously that the neuropeptide pituitary adenylyl cyclase-activating polypeptide (PACAP) negatively regulates proliferation of postnatal rat retinal progenitor cells through the downregulation of cyclin D1 in a cAMP/protein kinase A dependent manner. In the present study, we describe by microarray analysis several putative PACAP targets regulated by different transcription ...
Zander Mark A MA Neuroscience and Mental Health Program, Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada, and Institute of Medical Science and Departments of Molecular Genetics and Physiology, University of Toronto, Toronto, Ontario M5G 1X5, - - 2014
The Snail transcription factor plays a key role in regulating diverse developmental processes but is not thought to play a role in mammalian neural precursors. Here, we have examined radial glial precursor cells of the embryonic murine cortex and demonstrate that Snail regulates their survival, self-renewal, and differentiation into intermediate ...
Shibata Yuki - - 2014
Two types of AQP5 genes (aqp-xt5a and aqp-xt5b) were identified in the genome of Xenopus tropicalis by synteny comparison and molecular phylogenetic analysis. When the frogs were in water, AQP-xt5a mRNA was expressed in the skin and urinary bladder. The expression of AQP-xt5a mRNA was significantly increased in dehydrated frogs. ...
Emori Chihiro C Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, - - 2014
Mammalian oocytes secrete transforming growth factor β (TGF-β) superfamily proteins, such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 6 (BMP6) and BMP15, and fibroblast growth factors (FGFs). These oocyte-derived paracrine factors (ODPFs) play essential roles in regulating the differentiation and function of somatic granulosa cells as well as ...
Catlin Natasha R NR 1Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, - - 2014
Over the past decade, laser capture microdissection (LCM) has grown as a tool for gene expression profiling of small numbers of cells from tumor samples and of specific cell populations in complex tissues. LCM can be used to study toxicant effects on selected cell populations within the testis at different ...
Kataoka Hiroshi H Department of Medicine II, Hokkaido University Graduate School of Medicine , Sapporo , - - 2014
Objectives. To investigate the role of Foxp3(+) CD25(+) CD4(+) regulatory T cells (Treg) and their transcription factor, Runt-related transcription factor 1 (Runx1), in the pathogenesis and development of systemic sclerosis (SSc). Methods. We collected 23 blood samples from patients with SSc including 19 females and 4 males, 11 early-stage cases ...
Goeman Frauke F Translational Oncogenomics Unit, Italian National Cancer Institute "Regina Elena", 00144 Rome, Italy. Electronic address: - - 2014
There is growing evidence that 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) plays a role in breast cancer prevention and survival. It elicits a variety of antitumor activities like controlling cellular differentiation, proliferation and angiogenesis. Most of its biological effects are exerted via its nuclear receptor which acts as a transcriptional regulator. Here, we ...
Gill Roop Ms RM Department of Comparative Biomedical Sciences, The Royal Veterinary College, university of London, Royal College Street, London NW1 OTU, UK; Centre for Tumour Biology, Barts and the London School of Medicine and Dentistry, Queen Mary College, University of London, EC1M 6BQ, - - 2014
This study highlights the highly dynamic nature of SULF1/SULF2 splice variants in different human pancreatic cancers that regulate the activities of multiple cell signalling pathways in development and disease. Most pancreatic tumours expressed variable levels of both SULF1 and SULF2 variants including some expression during inflammation and pancreatitis. Many ductal ...
Zheng Yan-Fang YF Fujian University of Traditional Chinese Medicine, No. 1, Huatuo Road, Minhoushangjie, 350122 Fuzhou, - - 2014
Emodin (1, 3, 8-trihydroxy-6-methylanthraquinone) is a stimulant laxative and used to treat constipation. Aquaporin 3 (AQP3) plays an important role in regulating water transfer in the colon. In the study, we investigated whether the laxative effect of emodin is associated with the regulation of AQP3 in the colon. Our results ...
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