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Guo Zhentao Z Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, - - 2014
Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a tumor suppressor gene and may be related to tumor drug resistance. In this study, we explored whether LRIG1 protein expression can ...
Sung Hye Youn HY Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, - - 2014
Recent discoveries suggest that aberrant DNA methylation provides cancer cells with advanced metastatic properties. However, the precise regulatory mechanisms controlling metastasis genes and their role in metastatic transformation are largely unknown. To address epigenetically-regulated gene products involved in ovarian cancer metastasis, we examined the mechanisms regulating mucin 13 (MUC13) expression ...
Sheng Xiu-Jie XJ Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. - - 2014
Metastasis-associated in colon cancer 1 (MACC1) is a newly identified gene that has been shown to promote tumor cell invasion and metastasis. The present study investigated the effect of MACC1 downregulation on the biological characteristics of the ovarian cancer OVCAR3 cell line. In this study, MACC1 expression was blocked using ...
Yang Jia-Jun JJ Department of Neurology, Sixth People's Hospital of Shanghai Jiao Tong University, Shanghai 200233, P.R. - - 2014
The aim of this study was to investigate the effects of pentylenetetrazol (PTZ) and nuclear factor κ B (NF-κB) decoy oligodeoxynucleotides (ODNs) on p38 expression in neuron-like PC12 cells. In addition, the role of NF-κB activation in the pathogenesis of epilepsy was explored. p38 expression levels in control and PTZ-treated ...
Qiu Guoqiang G Laboratory of Hematology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu 213003, P.R. - - 2014
The present study examined the effects of simvastatin on the proliferation, apoptosis and gene expression levels involved in the nuclear factor-κB (NF-κB) signaling pathway in the human acute promyelocytic leukemia NB4 cell line by methyl thiazolyl tetrazolium assay, flow cytometry and the Human NF-κB Signaling Pathway RT(2) Profiler™ PCR Array ...
Peng Tian-Shu TS Department of Anorectal Disease, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410005, P.R. - - 2014
Protein phosphatase, Mg(2+)/Mn(2+) dependent, 1D (PPM1D) has been associated with carcinogenesis. The present study investigated PPM1D expression as a potential biomarker in colorectal cancer (CRC). PPM1D expression was assessed using immunohistochemistry in 368 patients with CRC. The correlation between PPM1D expression, clinicopathological features and prognosis was analyzed. PPM1D small interfering ...
Xiao Hui H Department of Laboratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, P.R. - - 2014
c-Kit and epidermal growth factor receptor (EGFR) have critical roles in cell proliferation and differentiation in patients with non-small cell lung cancer (NSCLC). The present study aimed to investigate the prognostic impact of c-Kit and/or EGFR expression in tumor tissue samples from 146 patients with NSCLC. c-Kit expression was analyzed ...
Yu Guiping G Department of Cardiothoracic Surgery, The Affiliated Jiangyin Hospital of Southeast University Medical College, No. 163, Shoushan Rd, Jiangyin, 214400, - - 2014
The aim of this study was to determine the relationship and underlying mechanisms between ectopic expression of phosphatidylethanolamine-binding protein 4 (PEBP4) and cisplatin (DDP)-induced cytotoxicity in the lung cancer cell line A549 to provide an experimental basis for future chemotherapeutic applications involving PEBP4 in human lung cancer. A recombinant plasmid, ...
Fernández-Pérez Antonio - - 2014
Alterations in transcription factors expressed in insulin-producing islet β cells generate pancreatic dysfunction leading to diabetes. The homeodomain transcription factor Alx3 expressed in pancreatic islets participates in the regulated expression of several islet genes, and its deficiency in mice leads to islet cell apoptosis and glucose intolerance. In this study, ...
Yan Hong H State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, - - 2014
Aim:Expression of liver low-density lipoprotein receptor (LDLR), a determinant regulator in cholesterol homeostasis, is tightly controlled at multiple levels. The aim of this study was to examine whether proteasome inhibition could affect LDLR expression and LDL uptake in liver cells in vitro.Methods:HepG2 cells were examined. Real-time PCR and Western blot ...
Ho P W M PW St. Vincent's Institute of Medical Research and Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, - - 2014
Osteosarcoma (OS) is the most common cancer of bone. Parathyroid hormone (PTH) regulates calcium homeostasis and bone development, while the paracrine/autocrine PTH-related protein (PTHrP) has central roles in endochondral bone formation and bone remodeling. Using a murine OS model, we found that OS cells express PTHrP and the common PTH/PTHrP ...
Williams Paul P Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden, - - 2014
The protein nucleobindin 1 (NUCB1; also known as CALNUC or Nuc) contains an intriguing combination of DNA- and calcium-binding motifs, a trait that it shares with the protein nucleobindin 2 (NUCB2; also known as nesfatin). NUCB2 has been implicated in several aspects of metabolic control and has been identified in ...
An Eunkyung E NIH, United - - 2014
In addition to forming macrophages and dendritic cells, monocytes in adult peripheral blood retain the ability to develop into osteoclasts, mature bone-resorbing cells. The extensive morphological and functional transformation that occurs during osteoclast differentiation requires substantial reprogramming of gene and protein expression. Here we employ -omic scale technologies to examine ...
Quan Meiling M Department of Orthopedics, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Republic of - - 2014
Steroid applications are able to repress inflammatory activity in various conditions, including herniation of the nucleus pulposus (HNP), by inhibiting tumour necrosis factor (TNF)-α, but the effects of long-term use are unknown. Here, we investigated the effect of dexamethasone (DEXA) on TNF-α-stimulated intervertebral disc cells by monitoring the expression and ...
Nagamura Yuko - - 2014
Rikkunshito is a traditional Japanese herbal medicine that is used to treat appetite loss associated with cancer and other disorders. The formulation contains various constituents that influence cell signaling, and rikkunshito may accordingly affect human homeostasis through multiple regulatory pathways, including those governed by the endocrine system. We investigated the ...
Fuerst Elisabeth E Division of Asthma, Allergy and Lung Biology, King's College London, London, UK; MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, - - 2014
Increased proliferation of airway smooth muscle (ASM) cells leading to hyperplasia and increased ASM mass is one of the most characteristic features of airway remodelling in asthma. A bioactive lipid, sphingosine-1-phosphate (S1P), has been suggested to affect airway remodelling by stimulation of human ASM cell proliferation. To investigate the effect ...
Pipino Caterina C School of Medicine and Health Sciences ''G. d'Annunzio'' University Chieti-Pescara, Chieti, Italy; Aging Research Center, Ce.S.I., ''Università G. d'Annunzio'' Foundation, Chieti, Italy; StemTeCh Group, Chieti Italy, Department of Experimental and Clinical Sciences, Italy ; - - 2014
Mesenchymal stem cells derived from human amniotic fluid (hAFMSCs) is a promising model for therapeutic applications in bone damage. Calcium Sensing Receptor (CaSR), a G protein-coupled receptor, plays a physiological role in the regulation of bone metabolism. Thus, the bone CaSR could be targeted by calcimimetic agonists, which may be ...
Leal Mariana Ferreira MF Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, R. Botucatu, 740, São Paulo, SP, CEP 04023-900, Brazil, - - 2014
Gastric cancer (GC) is the second highest cause of cancer mortality worldwide. However, nowadays, most of the studies aiming to understand the gastric carcinogenesis analyzed tumors of individuals from Asian population and, thus, may not reflect the distinct biological and clinical behaviors among GC processes. Since several membrane proteins have ...
Favorskaya Irina I Oncogenes Regulation Department, Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Kashirskoye shosse 24, Moscow, Russia, 115478, - - 2014
The impairment of retinoic acid (RA)-dependent signaling is a frequent event during carcinogenesis. Cellular retinoic acid-binding proteins (CRABP1 and CRABP2) are important modulators of RA activity. Up to date, the role of these proteins in cancer progression remains poorly investigated. Here, we studied for the first time the simultaneous messenger ...
Skogberg Gabriel G Department of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden; - - 2014
Down syndrome (DS), caused by trisomy of chromosome 21, is associated with immunological dysfunctions such as increased frequency of infections and autoimmune diseases. Patients with DS share clinical features, such as autoimmune manifestations and specific autoantibodies, with patients affected by autoimmune polyendocrine syndrome type 1. Autoimmune polyendocrine syndrome type 1 ...
Powell D J DJ Faculty of Veterinary Science, The University of Sydney, Camden, NSW 2750, Australia Poultry Cooperative Research Centre, PO Box U242, University of New England, Armidale, NSW 2351, - - 2014
Satellite cells (SC) are a multipotential stem cell population responsible for facilitating posthatch muscle fiber hypertrophy. The proliferation and differentiation of SC is sensitive to nutritional regimen, and the SC response to nutrition varies depending upon their muscle type of origin. The objective of the current study was to determine ...
Soboll Hussey Gisela G Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, East Lansing, MI, USA. Electronic address: - - 2014
Recently, the product of equine herpesvirus type 1 (EHV-1) ORF1, a homolog to HSV-1 pUL56, was shown to modulate MHC-I expression and innate immunity. Here, we investigated modulation of respiratory epithelial immunity by EHV-1 pUL56 and compared responses to those of PBMCs, which are important target cells that allow cell-associated ...
Bologna-Molina Ronell R *Department of Molecular Pathology, School of Dentistry, Universidad de la República (UDELAR), Montevideo, Uruguay †Department of HealthCare, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, - - 2014
Although benign, ameloblastomas are locally invasive and destructive tumors of the jawbones. The glypicans comprise a family of glycosylphosphatidylinositol-anchored proteoglycans that, by virtue of their cell-surface localization and heparin sulfate chain composition, might regulate the response of cells to numerous heparin-binding growth factors, cell adhesion molecules, and extracellular matrix components. ...
Ettorre Michele M Department of Neurological and Movement Sciences, Section of Physiology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy; Center for Biomedical Computing, University of Verona, Strada le Grazie 8, 37134 Verona, Italy. Electronic address: - - 2014
Cystic Fibrosis is caused by mutations of CFTR gene, a protein kinase A-activated anion channel, and is associated to an persistent and excessive chronic lung inflammation, suggesting functional alterations of immune cells. Leukocytes express detectable levels of CFTR but the molecule has not been fully characterized in these cells. Freshly ...
Bao Y Y First Affiliated Hospital, Huzhou Teachers College, the First People's Hospital of Huzhou, Huzhou 313000, - - 2014
Background:Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII, also known as NR2F2) promotes metastasis by functioning in the tumour microenvironment; however, the role of COUP-TFII in colorectal cancer remains unknown.Methods:Human colon adenocarcinoma tissues were collected to test COUP-TFII expression. Wound-healing and cell invasion assay were used to evaluate migration and invasion ...
Zhang Dandan D College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, People's Republic of - - 2014
Tapetal programmed cell death (PCD) is a prerequisite for pollen grain development in angiosperms, and cysteine proteases are the most ubiquitous hydrolases involved in plant PCD. We identified a papain-like cysteine protease, CEP1, which is involved in tapetal PCD and pollen development in Arabidopsis thaliana. CEP1 is expressed specifically in ...
Sievers Susanne S Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, - - 2014
The multicopy sRNA LhrC of the intracellular pathogen Listeria monocytogenes has been shown to be induced under infection-relevant conditions, but its physiological role and mechanism of action is not understood. In an attempt to pinpoint the exact terms of LhrC expression, cell envelope stress could be defined as a specific ...
Kirschner Karin M KM Charite-Universitaetsmedizin Berlin, - - 2014
Amine oxidase copper containing 1 (AOC1, formerly known as amiloride-binding protein 1, ABP1) is a secreted glycoprotein, which catalyzes the degradation of putrescine and histamine. Polyamines and their diamine precursor putrescine are ubiquitous to all organisms and fulfill pivotal functions in cell growth and proliferation. Despite the importance of AOC1 ...
Jeong Jin Young JY Division of Animal Genomics and Bioinformatics, National Institute of Animal science, Rural Development Administration, #564 Omockchun-dong, Suwon, 441-706, Republic of - - 2014
Epigallocatechin gallate (EGCG), a major component of tea, has known effects on obesity, fatty liver, and obesity-related cancer. We explored the effects of EGCG on the differentiation of bovine mesenchymal stem cells (BMSCs, which are multipotent) in a dose- and time-dependent manner. Differentiating BMSCs were exposed to various concentrations of ...
Hyun Soo-Wang SW College of Pharmacy, Ajou University, Suwon 443-749, Republic of Korea; Graduate Program of Molecular Medicine, Ajou University School of Medicine, Suwon 443-749, Republic of - - 2014
The Forkhead box O 3a (FoxO3a), a transcription factor, is known to be involve in change of endothelial permeability. During hypoxia, blood-brain barrier (BBB) permeability is increased through degradation of vascular endothelium cadherin (VE-cadherin) and clsudin-5. The hypoxia also increased mRNA levels of matrix metalloproteinase (MMP)-3/9 and promoted translocation of ...
Huang Qingfeng Q Department of Neurosurgery, Affiliated Hospital of Nantong University, Jiangsu Key Laboratory of Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, - - 2014
Nuclear factor of activated T cells 45 kDa (NF45), is a transcription factor that interacts with NF90 to regulate gene expression. It has been proved to be associated with tumor proliferation in various human malignancies. However, the role of NF45 in glioma is poorly understood. The aim of our study was ...
Ren Wen Hao WH Department of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University, Number 98, Xiwu Road, Xi'an, 710004, Shaanxi, People's Republic of - - 2014
Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Here, we evaluated the expression of cold-inducible RNA-binding protein (CIRP) and toll-like receptors 4 (TLR4) in OSCC tissues with immunohistochemistry. Using biostatistical methods designed to assess the impact of the expression of CIRP and TLR4 on the ...
Koutroutsos Konstantinos K 1st Department of Pathology, Medical School, University of Athens , Greece - - 2014
Abstract Background: Mature podocytes are in cell cycle arrest and their inability to proliferate successfully is a consequence of negative cell-cycle regulators' expression, such as p57. Phosphorylated smad2/smad3 (pSmad2/3) is an intracellular heteromeric mediator of transforming growth factor beta (TGF-β) signals and, together with co-activators such as P300, regulates gene ...
Semenova S A SA Neuroscience Center, University of Helsinki, Helsinki, - - 2014
Two tyrosine hydroxylases (TH1 and TH2) are found in teleost fish, but no antibodies are available for TH2 protein to analyze the detailed structure of the system. We generated antibodies targeting TH2 and used them to characterize the TH2-producing cells in larval and adult zebrafish brain. The rabbit antisera reliably ...
Sirotkin Alexander V AV Constantine The Philosopher University in Nitra, Nitra, Slovakia, - - 2014
The roles of the mTOR system enzyme sirtuin 1 (SIRT1), the transcription factor p53 and the nuclear factor kappaB (NF-κB) and their interrelationships in the control of ovarian function have not been well studied. We examine, in vitro, the involvement of SIRT1, p53 and the p65 and p50 subunits of ...
Lee So Hee - - 2014
Tight junction protein 1 (TJP1), a component of tight junction, has been reported to play a role in protein networks as an adaptor protein, and TJP1 expression is altered during tumor development. Here, we found that TJP1 expression was increased at the RNA and protein levels in TGFβ-stimulated lung cancer ...
Saraiva Raposo Rui André RA Division of Experimental Medicine, University of California San Francisco, California, USA Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA - - 2014
In this study, we investigated the expression levels of host restriction factors in six untreated HIV-1-positive patients over the course of infection. We found that the host restriction factor gene expression profile consistently increased over time and significantly associated with CD4(+) T cell activation and viral load. Our data are ...
Boopathi Ettickan E University of - - 2014
Partial bladder outlet obstruction (pBOO)-induced remodeling of bladder detrusor smooth muscle (DSM) is associated with the modulation of cell signals regulating contraction. We analyzed the DSM from obstructed murine urinary bladders for the temporal regulation of RhoA GTPase and Rho-activated kinase (ROCK), which are linked to Ca(2+)-sensitization. In addition, the ...
Gruber Andreas J AJ Biozentrum, University of Basel, Klingelberstrasse 50-70, CH-4056 Basel, - - 2014
The findings that microRNAs (miRNAs) are essential for early development in many species and that embryonic miRNAs can reprogram somatic cells into induced pluripotent stem cells suggest that these miRNAs act directly on transcriptional and chromatin regulators of pluripotency. To elucidate the transcription regulatory networks immediately downstream of embryonic miRNAs, ...
Pan Zhi-Qiang ZQ Department of Physiology, Georgia Regents University (Medical College of Georgia), 1120 15th Street, Augusta, Georgia 30912, USA; School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, - - 2014
Pioglitazone belongs to the class of drugs called thiazolidinediones (TZDs), which are widely used as insulin sensitizers in the treatment of diabetes. A major side effect of TZDs is fluid retention. The steroid hormone aldosterone also promotes sodium and fluid retention; however, the effect of pioglitazone on aldosterone production is ...
Chen Hu H State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006 P. R. - - 2014
Adipocyte differentiation is tightly regulated by altering gene expression in which microRNAs might be strong post-transcriptional regulators. In this study, we examined the roles of miR-709 in adipogenic differentiation of 3T3-L1 preadipocyte. We found that miR-709 expression was down-regulated during adipogenesis after MDI (1-methyl-3-isobutylxanthine, dexamethasone and insulin) stimulation in normal ...
Wahlström Therese T Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Box 280, SE-171 77 Stockholm, - - 2014
The MYC proto-oncoproteins including c-MYC, MYCN and MYCL exert their functions as heterodimers with MAX, which in turn binds to E-box sequences at target promoters to regulate gene expression. It has been shown that MYC binds to 10-15 % of all promoter regions and regulates genes involved in a wide ...
Neal Christopher P CP Cancer Studies and Molecular Medicine, The Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United - - 2014
The serine/threonine kinase Nek2 (NIMA-related kinase 2) regulates centrosome separation and mitotic progression, with overexpression causing induction of aneuploidy in vitro. Overexpression may also enable tumour progression through effects upon Akt signalling, cell adhesion markers and the Wnt pathway. The objective of this study was to examine Nek2 protein expression ...
Gage Philip J PJ Department of Ophthalmology & Visual Science, University of Michigan Medical School, Ann Arbor, MI, 48105, USA; Department of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, 48105, - - 2014
Background: Correct specification of cell lineages and establishing angiogenic privilege within the developing cornea are essential for normal vision but the mechanisms controlling these processes are poorly understood. Results: We show that the homeodomain transcription factor PItX2 is expressed in mesenchymal cells of the developing and mature cornea and use ...
Co Ngai Na NN Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, - - 2014
Liver kinase B1 (LKB1) is a serine/threonine kinase that functions as a tumor suppressor and regulates cell polarity, proliferation, and metabolism. Mutations in LKB1 are associated with Peutz-Jeghers syndrome as well as sporadic cervical and lung cancers. Although LKB1-null mice develop invasive endometrial cancers, the role and regulation of LKB1 ...
Mahoney John E JE Columbia Center for Human Development, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA; Department of Pathology, Boston University School of Medicine, Boston, MA 02118, - - 2014
How epithelial progenitor cells integrate local signals to balance expansion with differentiation during organogenesis is still little understood. Here, we provide evidence that the Hippo pathway effector Yap is a key regulator of this process in the developing lung. We show that when epithelial tubules are forming and branching, a nucleocytoplasmic ...
Espinosa S S Barcelona Cardiovascular Research Center (CSIC-ICCC), IIB-Sant Pau, Hosp Sant Pau, UAB, Barcelona, - - 2014
Atherosclerosis is characterized by lipid accumulation, inflammation and neovascularization. Advanced atherosclerotic plaques can be destabilized and become vulnerable to rupture by microcapillary formation and inflammatory cell infiltration; and can lead to thrombosis and acute coronary syndromes. We have demonstrated in previous studies that increased tissue factor (TF) expression, that it ...
Wang Juandong J Department of Hematology, The Second Hospital of Shandong University, Jinan, 250033, People's Republic of China, - - 2014
To detect the expression of cancerous inhibitor of phosphatase 2A (CIP2A) in chronic myelocytic leukemia (CML) and investigate the mechanism underlying CIP2A knockdown-mediated cell proliferation and apoptosis as well as the interaction of CIP2A with breakpoint cluster region-Abelson leukemia virus (BCR-ABL). CIP2A mRNA and protein expression in chronic myelocytic leukemia-chronic ...
Chaabane C C University of Geneva, Pathology and Immunology, Geneva, - - 2014
Apelin, and its receptor APJ, are a peptidic system playing a crucial role in vascular diseases. However, the role of apelin in atherogenesis and smooth muscle cell (SMC) proliferation remains unclear. We isolated 2 distinct SMC phenotypes from porcine coronary artery: spindle-shaped (S) and rhomboid (R). Biological features of R-SMCs ...
Tribulova N N Slovak Academy of Sciences, Institute for Heart Research, Bratislava, Slovak - - 2014
Mechanisms underlying atrial fibrillation (AF) the most common cardiac arrhythmia in aged population are not fully elucidated. We have previously shown that unlike to young the aged guinea pig heart is much prone to develop AF upon repetitive burst stimulation. We hypothesize that in addition to atrial structural remodeling the ...
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