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Hsu Eric W - - 2014
The endogenous RNA interference (RNAi) pathway enables control of pathologies caused by the dysregulation of proteins. Several biological molecules are active in RNAi including short interfering ribonucleic acid (siRNA). The effective utilization of siRNA as a therapeutic agent has been marked with distinct challenges, namely in intracellular delivery and achieving ...
Aryal Binod B Vascular Biology and Therapeutics Program, Yale University School of Medicine, 10 Amistad Street, Amistad Research Building, Room 337C, New Haven, CT, 06510, - - 2014
Noncoding RNAs (ncRNAs) represent a class of RNA molecules that typically do not code for proteins. Emerging data suggest that ncRNAs play an important role in several physiological and pathological conditions such as cancer and cardiovascular diseases, including atherosclerosis. The best-characterized ncRNAs are the microRNAs which are small, approximately 22-nucleotide ...
Armenia Joshua J Division of Experimental Oncology 2, CRO, National Cancer Institute, Aviano, - - 2014
MicroRNAs (miRs) are a large class of small regulatory RNAs that function as nodes of signaling networks. This implicates that miRs expression has to be finely tuned, as observed during cell cycle progression. Here, using an expression profiling approach, we provide evidence that the CDK inhibitor p27Kip1 regulates miRs expression ...
Barnie Prince Amoah PA Department of Immunology, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. - - 2014
The aim of the present study was to investigate the effect of CpG-oligodeoxynucelotides (CpG-ODN) on the proliferation of the A549 human lung adenocarcinoma cell line and the expression of Runt-related transcription factor 3 (Runx3) and investigate the association between the toll-like receptor 9 (TLR9) signaling pathway and Runx3 expression during ...
Xu Quanfu Q Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, - - 2014
Dysfunction of endothelial progenitor cells (EPC) contribute to diabetic vascular disease. MicroRNAs (miRNAs) are key regulators of diverse cellular processes, including angiogenesis. We recently reported that downregulated miR-130a in patients with Type 2 diabetes mellitus (DM) results in EPC dysfunction, including increased apoptosis, likely via its target runt-related transcription factor ...
Alper Meltem M Department of Biology, Faculty of Science and Literature, Balıkesir University, Balıkesir, 10145, - - 2014
ADAMTS-2 and ADAMTS-3 (a disintegrin and metalloproteinase with thrombospondin type 1 motif 2) belong to the procollagen aminoproteinase subfamily of ADAMTS proteases. They play crucial roles in the collagen metabolism. To understand the regulation of ADAMTS-2 gene expression in osteoblastic cells, we have cloned a functional 760 bp of human ADAMTS-2 ...
Bai Chaogang C State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of - - 2014
Interleukin-24 (IL-24) is a novel cytokine selectively inhibiting proliferation of cancer cells but with little effect on normal cells. However, IL-24 is difficult to express in Escherichia coli. In this study, we optimised the secondary structure of the translation initiation region using computational approach to obtain non-fusion recombinant IL-24 (nrIL-24). ...
Kim Ju Deok JD Department of Anesthesiology and Pain Medicine, Kosin University Gospel Hospital, 34 Amnam-dong, Seogu, Busan, 602-702, - - 2014
Surgery during pregnancy can be a cause of preterm labor or birth, possibly resulting from anesthetic agents or direct effects of surgery. This study was aimed to investigate the effect of propofol on uterine contractility by examining prostaglandin E2 (PGE2) production and the expression of PGE synthase 2 (PGES2) and ...
Thiel Gerald G Department of Medical Biochemistry and Molecular Biology, University of Saarland, Homburg, - - 2014
Many intracellular functions have been attributed to resveratrol, a polyphenolic phytoalexin found in grapes and in other plants, including the regulation of transcription. Here, we have analyzed the impact of resveratrol on the activity of the transcription factor activator protein-1 (AP-1). Using a chromosomally embedded AP-1-responsive reporter gene, we show ...
Press T T Department of Cranio- and Maxillofacial Surgery, ], D-93053, Regensburg, - - 2014
To evaluate whether and how the transcription factor early growth response gene 1 (EGR1) affects the osteogenic differentiation of dental stem cells. Dental stem cells from apical papilla (SCAPs) and from the dental follicle (DFCs) were transfected with EGR1 specific siRNA or EGR-1 expression plasmid. Gene regulation was verified at ...
He Zhenning - - 2014
The normal accumulation of adult alpha and beta globins in definitive erythrocytes is critically dependent upon processes that ensure that the cognate mRNAs are maintained at high levels in transcriptionally silent, but translationally active progenitor cells. The impact of these post-transcriptional regulatory events on the expression of embryonic zeta globin ...
O'Neill Daniel J DJ Northern Institute for Cancer Research; Newcastle University; Newcastle upon Tyne, - - 2014
The lysine methyltransferase SETD6 modifies the histone variant H2AZ, a key component of nuclear receptor-dependent transcription. Herein, we report the identification of several factors that associate with SETD6 and are implicated in nuclear hormone receptor signaling. Specifically, SETD6 associates with the estrogen receptor α (ERα), histone deacetylase HDAC1, metastasis protein ...
Waight Jeremy D JD Roswell Park Cancer Institute, United - - 2014
Tyrosine kinase inhibitors such as imatinib can effectively target the BCR-ABL oncoprotein in a majority of patients with chronic myeloid leukemia (CML). Unfortunately, some patients are primarily resistant to imatinib and others develop drug resistance, prompting interest in the discovery of new drug targets. Although much of this resistance can ...
Liu Zhen - - 2014
CDK4 is a protein kinase in the CDK family important for G1/S phase cell cycle progression. However, the roles and molecular mechanisms of CDK4 triggering nasopharynx carcinogenesis are still unclear. Lentiviral-vector mediated shRNA was used to suppress CDK4 expression and examine its molecular mechanisms. Using immunohistochemistry, we analyzed CDK4 protein ...
Lee Kyuwan K 1] Department of Bioengineering, Department of Electrical Engineering and Computer Science, University of California Berkeley, Berkeley, California 94720, USA [2] Department of Agricultural and Biological Engineering, Bindley Bioscience Center, Purdue University, 225 South University Street, West Lafayette, Indiana 47907, - - 2014
Alternative messenger RNA (mRNA) splicing is a fundamental process of gene regulation, and errors in RNA splicing are known to be associated with a variety of different diseases. However, there is currently a lack of quantitative technologies for monitoring mRNA splice variants in cells. Here, we show that a combination ...
Shin Ilchung I Ames Laboratory, US Department of Energy, Ames, IA 50011, - - 2014
We describe a ribonucleic acid (RNA) reporter system for live-cell imaging of gene expression to detect changes in polymerase II activity on individual promoters in individual cells. The reporters use strings of RNA aptamers that constitute IMAGEtags (Intracellular MultiAptamer GEnetic tags) that can be expressed from a promoter of choice. ...
Wang Li L Department of Histology and Embryology, Weifang Medical University, Weifang, Shandong, People's Republic of - - 2014
Neural stem cells (NSCs) are involved in neural tube formation. As the high-mobility group box 1 (HMGB1) protein is involved in neurulation and is present at elevated levels in neural tube defects (NTDs) induced by hyperthermia, we have now investigated the effects of HMGB1 on proliferation, differentiation, and MAPK signaling ...
Guo Wei W Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987; Pathology Department, Wuhan University, 185 Donghu Rd., Wuhan, Hubei 430071, - - 2014
p27(kip1) is a potent inhibitor of the cyclin-dependent kinases that drive G1 to S phase transition. Since deregulation of p27(kip1) is found in many malignancies and is associated with the poor prognosis, elucidation of the molecular bases for regulation of p27(kip1) expression is of great significance, not only in providing ...
Highley J Robin JR Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, United - - 2014
Loss of nuclear TDP-43 characterises sporadic and most familial forms of amyotrophic lateral sclerosis (ALS). TDP-43 (encoded by TARDBP) has multiple roles in RNA processing. We aimed to determine whether 1) RNA splicing dysregulation is present in lower motor neurons in ALS and in a motor neuron-like cell model, and ...
Ning Bei-Fang BF Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, - - 2014
Hepatocyte nuclear factor 4α (HNF4α) is a liver enriched transcription factor and is indispensable for liver development. However, role of HNF4α in hepatocellular carcinoma (HCC) progression remains to be elucidated. Herein, we report that reduced HNF4α expression correlated well with the aggressive clinicopathological characteristics of HCC and predicted poor prognosis ...
Wang Tao T General Surgery Center, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, - - 2014
In a previous study, the Notch pathway inhibited with N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (also called DAPT) was shown to promote the differentiation of fetal liver stem/progenitor cells (FLSPCs) into hepatocytes and to impair cholangiocyte differentiation. The precise mechanism for this, however, was not elucidated. Two mechanisms are possible: Notch inhibition might ...
Xiao Sheng S Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, - - 2014
We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including Th17-cell-mediated autoimmune disease. We systemically characterized RORγt binding in the presence and absence of drugs with corresponding whole-genome transcriptome sequencing. RORγt acts as a direct activator of Th17 cell signature genes ...
Sakamoto Yuima Y Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan; Laboratory of applied pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Sciences, 2641 Yamazaki, Noda, Chiba 278-8510, - - 2014
Aquaporin-5 (AQP5) is a water-selective channel protein that is expressed in submucosal glands and alveolar epithelial cells in the lungs. Recent studies have revealed that AQPs regulate not only water metabolism, but also some cellular functions such as cell growth and migration. Here, we report the role of AQP5 in ...
Liu Xi X Department of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. - - 2014
Endothelin-1 (ET-1)-induced cell damage is commonly involved in ischemia/hypoxia-associated diseases. PD155080 [sodium 2-benzo (1.3)dioxol-5-yl-3-benzyl-4-(4‑metho-xyphenyl)-4-oxobut-2-enoate] is a selective endothelin A receptor (ETAR) antagonist that inhibits ET-1‑induced cell damage. The aim of this study was to investigate the effects of PD155080 on hypoxia-induced rat brain microvascular endothelial cell (BMEC) injury. BMECs were isolated from the ...
Wang Ning N Department of General Surgery, The First Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. - - 2014
The aim of the present study was to examine the regulation of selenium binding protein 1 (SELENBP1) expression in colorectal cancer (CRC). Samples of cancer tissue and adjacent normal mucosa were collected from 83 CRC patients, and analyzed for SELENBP1 expression by 2D-DIGE, immunoblotting, RT-PCR and immunostaining. Expression levels of ...
Wu Shu-Man - - 2014
Gingiva-derived mesenchymal stem cells (GMSCs) have recently been harvested and applied for rebuilding lost periodontal tissue. Enamel matrix derivative (EMD) has been used for periodontal regeneration and the formation of new cementum with inserting collagen fibers; however, alveolar bone formation is minimal. Recently, EMD has been shown to enhance the ...
Cao Cong C State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, - - 2014
Studies on the chaperone protein α-hemoglobin stabilizing protein (AHSP) reveal that abundant AHSP in erythroid cells enhance the cells' tolerance to oxidative stress imposed by excess α-hemoglobin in pathological conditions. However, the potential intracellular modulation of AHSP expression itself in response to oxidative stress is still unknown. The present study ...
Alimperti Stella - - 2014
Although soluble factors (e.g. Transform Growth Factor beta 1 (TGF-β1)) induced mesenchymal stem cell (MSC) differentiation toward smooth muscle (SMC) lineage, the role of adherent junctions in this process is not well understood. We found that Cadherin-11 but not Cadherin-2 was necessary for MSC differentiation into SMC. Cadherin-11 regulated expression ...
Benina Maria M Plovdiv University, Plant Physiology and Molecular Biology, 24 Tzar Assen Street, BG-4000 Plovdiv, Bulgaria; Institute of Molecular Biology and Biotechnology, Plovdiv, - - 2014
Oxidative stress causes dramatic changes in the expression levels of many genes. The formation of a functional protein through successful mRNA translation is central to a coordinated cellular response. To what extent the response towards reactive oxygen species (ROS) is regulated at the translational level is poorly understood. Here we ...
Huang Hongyu H State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, - - 2014
Triclosan (TCS) and triclocarban (TCC), as broad spectrum antibacterial agents, are distributed widely in the environment and humans. Most studies have focused on their distribution and biodegradation, but the endocrine-disrupting effects of these chemicals, especially their estrogenic effects, are still unclear. In the present study, we investigated the estrogenic effects ...
Vogt Daniel D Department of Psychiatry, Neuroscience Program and the Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address: - - 2014
Cortical GABAergic interneurons have essential roles for information processing and their dysfunction is implicated in neuropsychiatric disorders. Transcriptional codes are elucidating mechanisms of interneuron specification in the MGE (a subcortical progenitor zone), which regulate their migration, integration, and function within cortical circuitry. Lhx6, a LIM-homeodomain transcription factor, is essential for specification ...
Cechin Sirlene R SR Diabetes Research Institute Miller School of Medicine, University of Miami 1450 NW 10 Ave (R-134), Miami, FL - - 2014
Glucocorticoids are an important class of anti-inflammatory/immunosuppressive drugs. A crucial part of their anti-inflammatory action results from their ability to repress proinflammatory transcription factors such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) upon binding to the glucocorticoid receptor (GR). Accordingly, sensor cells quantifying their effect on inflammatory signal-induced NF-κB ...
Ueda Kiyotaka K Graduate School of Biological Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, - - 2014
Global translational repression under abiotic stress influences translation of both endogenous and transgene mRNAs. Even in plant cell culture, hypoxia and nutrient deficient stress arise during the growth process. In this study, we first demonstrated the existence of global translational repression in Arabidopsis T87 cultured cells over a time course ...
Komiya Eriko E Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, - - 2014
Malignant pleural mesothelioma (MPM) is an aggressive malignancy arising from mesothelial lining of pleura. It is generally associated with a history of asbestos exposure and has a very poor prognosis, partly due to the lack of a precise understanding of the molecular mechanisms associated with its malignant behavior. In the ...
Li Xiaoyan X Department of Pediatrics, Peking University First Hospital, Beijing 100034, - - 2014
Podocyte foot process (FP) is dysregulated in nephrotic syndrome. The effacement of podocyte FPs typically arises following perturbations in the actin cytoskeleton. Recent data suggest that the effects of calcineurin (CaN) inhibitor cyclosporine A (CsA) are independent of its effects on T-cells, and CsA has been identified as stabilizing the ...
Cheng Quan Q Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. - - 2014
Paired box 6 (PAX6), a highly conserved transcription factor, is important in glioma. However, the molecular mechanisms involved remain unclear. The present study demonstrated that the expression of PAX6 was significantly reduced with the malignancy of glioma and also identified PAX6 as a novel target of microRNA (miR)‑335, which was ...
Zhang Guang-Jun GJ The First Department of General Surgery, Institute of Hepato‑Biliary‑Pancreas and Intestinal Disease, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. - - 2014
Accumulating evidence indicates that dysregulated microRNAs (miRNAs) are involved in cancer development, progression and metastasis. miR‑20a was found to be involved in invasion and epithelial‑mesenchymal transition (EMT) programs, with its aberrant expression having been observed in a variety of malignant tumors. However, the molecular mechanisms underlying the role of miR‑20a ...
Barrios-García Tonatiuh T Instituto de Investigaciones Biomedicas, Universidad Nacional Autónoma de - - 2014
The estrogen receptor alpha (ERα) mediates the effects of 17β- estradiol (E2) in normal mammary gland and it is a key participant in breast cancer tumor development. ERα transactivation activity is mediated by the synergistic interaction of two domains designated AF1 and AF2. The function of AF2 is to recruit ...
Kawatsu Y Y Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu 807-8555, - - 2014
Background:The transcription factor, zinc finger protein 143 (ZNF143), positively regulates many cell-cycle-related genes. The ZNF143 would show high expression of multiple solid tumours related closely to cancer cell growth, similar to the widely accepted Ki67 (MIB-1) protein, but the underlying mechanisms for ZNF143 remain unclear. We investigated the association of ...
Wang Changshan C Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, - - 2014
Numerous studies have recently reported mutations involving multiple components of the mRNA splicing machinery in patients with myelodysplastic syndrome (MDS). SF3B1 is mutated in 70-85% of refractory anemia with ringed sideroblasts (RARS) patients and is highly associated with the presence of ringed sideroblasts, although the pathological role of SF3B1 mutations ...
Qu Shuang S Department of Hematology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Department of Hematology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, - - 2014
Internal tandem duplication of FMS-like tyrosine kinase (FLT3-ITD) is well known to be involved in acute myeloid leukemia (AML) progression, but FLT3-ITD-negative AML cases account for 70% to 80% of AML, and the mechanisms underlying their pathology remain unclear. This study identifies protein tyrosine phophatase PRL-3 as a key mediator ...
Ostvik Ann E AE *Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway; †Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; ‡Department of Gastroenterology and Hepatology, St. Olav's University Hospital, Trondheim, Norway; §Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway; ‖Department of Pathology and Medical Genetics, St. Olav's University Hospital, Trondheim, Norway; ¶Research Laboratory, Department of Laboratory Medicine, Nordland Hospital, Bodø, Norway; **Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway; K. G. Jebsen IRC, University of Oslo, Oslo, Norway; and ††Department of Infectious Diseases, St. Olav's University Hospital, Trondheim, - - 2014
Recent studies link Toll-like receptor 3 (TLR3) to the pathogenesis of inflammatory bowel disease (IBD). Screening TLR3-agonist response in an intestinal epithelial cell line, we found complement factor B mRNA (CFB) potently upregulated and went on to further study localization of complement factor B synthesis and systemic activation of complement ...
Tan Zengqi - - 2014
Epithelial-to-mesenchymal transition (EMT) is an essential biological process that occurs in embryonic development, metastatic diseases, and cancer progression. Altered expression of glycans is known to be associated with cancer progression. No studies to date have presented global analysis of the precise variation of N-glycans in EMT. We describe here the ...
Kumar V V Department of Molecular Medicine, Sapienza University, Rome, - - 2014
Notch signaling deregulation is linked to the onset of several tumors including T cell acute lymphoblastic leukemia (T-ALL). Deregulated microRNA (miRNA) expression is also associated to several cancers, including leukemias. However, the transcriptional regulators of miRNAs as well as the relationships between Notch signaling and miRNA deregulation are poorly understood. ...
Spirin P V PV Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, - - 2014
The t(8;21)(q22;q22) rearrangement represents the most common chromosomal translocation in acute myeloid leukemia (AML). It results in a transcript encoding for the fusion protein AML1-ETO (AE) with transcription factor activity. AE is considered to be an attractive target for treating t(8;21) leukemia. However, AE expression alone is insufficient to cause ...
Omori Akiko A Department of Developmental Genetics (A.O., G.Y.), Institute of Advanced Medicine, Wakayama Medical University, Wakayama, 641-8509, Japan; Okazaki Institute for Integrative Bioscience (S.M., Y.O.), National Institute for Basic Biology, National Institutes of Natural Science, Okazaki, 444-8787, Japan; Department of Clinical Anatomy (M.H.), Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, 113-8591, Japan; Department of Oncologic Pathology (K.I.), and Nephro-Urologic Surgery and Andrology (Y.S.), Mie University Graduate School of Medicine, Tsu, Mie, 514-8507, Japan; Department of Animal Bioscience (H.O.), Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga, 526-0829, Japan; and Division of Reproductive Engineering (N.N.), Center for Animal Resources and Development (CARD), Kumamoto University, Kumamoto 860-0811, - - 2014
Prostate is a male sex accessory organ. The prostatic epithelia consist primarily of basal and luminal cells that differentiate from embryonic urogenital sinus epithelia. Prostate tumors are believed to originate in the basal and luminal cells. However, factors that promote normal epithelial differentiation have not been well elucidated, particularly for ...
Dmitrieva Natalia I NI Renal Cellular and Molecular Biology Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD - - 2014
Hypercoagulability increases risk of thrombi that cause cardiovascular events. Here we identify plasma sodium concentration as a factor that modulates blood coagulability by affecting the production of von Willebrand factor (vWF), a key initiator of the clotting cascade. We find that elevation of salt over a range from the lower ...
Tan Frederick E FE Howard Hughes Medical Institute and Division of Biology and Departments of Bioengineering and Applied Physics, California Institute of Technology, Pasadena, CA - - 2014
AU-rich element mRNA-binding proteins (AUBPs) are key regulators of development, but how they are controlled and what functional roles they play depends on cellular context. Here, we show that Brf1 (zfp36l1), an AUBP from the Zfp36 protein family, operates downstream of FGF/Erk MAP kinase signaling to regulate pluripotency and cell ...
Chevallet Mireille M Université Grenoble Alpes, LCBM, F-38054 Grenoble, - - 2014
The canonical transient receptor potential 6 (TRPC6) protein is a non-selective cation channel able to transport essential trace elements like iron (Fe) and zinc (Zn) through the plasma membrane. Its over-expression in HEK-293 cells causes an intracellular accumulation of Zn, indicating that it could be involved in Zn transport. This ...
Jutooru Indira I Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX - - 2014
Reactive oxygen species (ROS)-inducing anticancer agents such as phenethyl isothiocyanate (PEITC) activate stress pathways for killing cancer cells. Here we demonstrate that PEITC-induced ROS decreased expression of microRNA-27a (miR-27a)/miR-20a:miR-17-5p and induced miR-regulated ZBTB10/ZBTB4 and ZBTB34 transcriptional repressors which, in turn, downregulate specificity protein (Sp) transcription factors (TFs) Sp1, Sp3 and ...
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