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Chen Xiaowan X Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, 110001, - - 2014
It is well known that the differential expression of long noncoding RNA (lncRNA) plays critical roles in carcinogenesis. However, the significance of lncRNA in the diagnosis of gastric cancer (GC) remains largely unknown. The goal of this study was to determine the expression level of AC138128.1, a novel lncRNA, in ...
Li Ying Y Center of Gerontology and Geriatrics, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. - - 2014
The aim of the present study was to investigate the function of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and cyclooxygenase-2 (COX-2) in angiogenesis and their association with the prognosis of non-small cell lung cancer (NSCLC). Using immunohistochemical staining, the expression of 15-PGDH and COX-2, and the microvessel density (MVD) levels were evaluated in ...
Li Li-Ping LP Department of Gastroenterology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. - - 2014
The present study aimed to identify the association between microRNA (miR/miRNA)-449a, the cyclin-dependent kinase (CDK)6 protein and gastric carcinoma, and discuss the effect of miR-449a on the expression of the CDK6 protein. Quantitative (q)PCR and western blot analysis were used to analyze the expression of the miR-449a and the CDK6 ...
Cho Soo Youn SY Department of Pathology and Translational Genomics, Samsung Medical Center, School of Medicine, Sungkyunkwan University, 50 Ilwon-dong, Gangnam-gu, Seoul, 135-710, - - 2014
Smad3 functions as an integrator of diverse signaling, including transforming growth factor β signaling and the function of Smad3 is complexly regulated by differential phosphorylation at various sites of Smad3. Despite the importance of Smad3 and its various phosphoisoforms, their prognostic significance has rarely been studied. In this study, we ...
Liu Qingquan Q Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR. - - 2014
Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a microtubule-associated protein that impacts spindle assembly in human cells. Several studies have shown that the overexpression of TPX2 is correlated with multiply tumor types. However, the role of TPX2 in hepatocellular carcinoma (HCC) remains undetermined. TPX2 expression was detected by ...
Jiang Shan-Shan - - 2014
BackgroundGalectin-3, a member of the beta-galactoside-binding lectin family, is a multifunctional protein with various biological functions, including the proliferation and differentiation of tumor cells, angiogenesis, cancer progression, and metastasis. We aimed to clarify if expression of galectin-3 is related to the clinicopathological characteristics and prognosis of hepatocellular carcinoma (HCC) patients, ...
Hu Stephen Chu-Sung SC Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, - - 2014
The chemokine receptor CXCR7 has been demonstrated to be involved in the development of certain cancers, but its role in cutaneous squamous cell carcinoma (SCC) has not been previously investigated. We seek to determine whether CXCR7 is expressed in human cutaneous SCC skin lesions and SCC cell lines. In addition, ...
Tang Y Y Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, - - 2014
We aim to evaluate the diagnostic value of ribonuclease inhibitor (RI) in colorectal cancer (CRC) and investigate the important role of RI in cell growth and metastasis of CRC. In this study, the expression of RI was evaluated in human CRC samples with different histological grade and the association between ...
Xu R H RH Department of Oncology Surgery, The Affiliated Hospital of Hainan Medical College, Haikou, 570102, - - 2014
To explore the expression profile of miRNAs during differentiation of rat hepatic oval cells (HOCs) into hepatocellular carcinoma cells (HCC). Proliferation of rat HOCs was induced by chemical carcinogen, 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) in male rats. By using Percoll density gradient centrifugation method, HOCs were isolated, followed by continuous cultivation in vitro. ...
Mondalek Fadee G FG Department of Urology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd., WP3150, Oklahoma City, OK, 73104, - - 2014
Hyaluronic acid (HA), a non-sulfated glycosaminoglycan, is an essential component of the extracellular matrix (ECM). Since HA is involved in many phases of wound healing and may play a key role in tissue repair and regeneration, this study was intended to understand temporal and spatial expression of HA and HA ...
Niu Yanfeng Y Departments of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, - - 2014
This study was designed to explore the correlation between expressions of SATB1 and S100A4 and their relationships to the clinicopathologic parameters of colorectal carcinoma (CRC). Expressions of SATB1 and S100A4 were evaluated by immunohistochemistry in a cohort of 131 primary CRC patients undergone surgical resection from 2005 to 2007. SATB1 ...
Oktyabri Dulamsuren D Division of Functional Genomics, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Ishikawa, - - 2014
Histone methylation is involved in various biological and pathological processes including cancer development. In this study, we found that EED, a component of Polycomb repressive complex-2 (PRC2) that catalyzes methylation of lysine 27 of histone H3 (H3K27), was involved in epithelial-mesenchymal transition (EMT) of cancer cells induced by Transforming Growth ...
Tang Bo B Department of Hepatobiliary Surgery, Guilin Medical University, Affiliated Hospital, Guilin, Guangxi, People's Republic of - - 2014
Emerging evidence indicates that C-X-C chemokine receptor type 4 (CXCR4) is a candidate oncogene in several types of human tumors including renal cell carcinoma (RCC). We conducted a meta-analysis to quantitatively evaluate the association of CXCR4 expression with the incidence of RCC and clinicopathological characteristics. We searched PubMed, Embase, and ...
Wang Hui H Department of Medical Oncology, Affiliated Tumor Hospital of Guangzhou Medical - - 2014
Purpose: The expression of LIM and SH3 protein 1 (LASP1) was up-regulated in colorectal carcinoma (CRC) cases, thereby contributing to the aggressive phenotypes of CRC cells. However, we still cannot decipher the underlying molecular mechanism associated with CRC metastasis. Experimental Design: In this study, immunohistochemistry was performed to investigate the ...
Sterenczak Katharina Anna - - 2014
Humans and dogs are affected by squamous cell carcinomas of the oral cavity (OSCC) in a considerably high frequency. The high mobility group A2 (HMGA2) protein was found to be highly expressed in human OSCC and its expression was suggested to act as a useful predictive and prognostic tool in ...
Liu Caihong C Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, - - 2014
microRNAs (miRNAs) have been documented playing a critical role in cancer development and progression. In this study, we investigated the role of miR-548l in non-small cell lung cancer (NSCLC) migration and invasion. microRNAs microarray analysis was used to detect the differentially expressed miRNAs between various metastatic levels of NSCLC cells ...
So Wai-Kin WK Department of Obstetrics and Gynecology, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, - - 2014
Aberrant epidermal growth factor receptor (EGFR) activation is associated with ovarian cancer progression. In this study, we report that the EGFR ligand amphiregulin (AREG) stimulates cell invasion and down-regulates E-cadherin expression in two human ovarian cancer cell lines, SKOV3 and OVCAR5. In addition, AREG increases the expression of transcriptional repressors ...
Khattri Arun A Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL, - - 2014
The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor and is overexpressed in up to 90% of head and neck squamous cell carcinoma (HNSCC) cases. The EGFR truncation mutation, EGFR variant III (EGFRvIII), harbors an in-frame deletion of exons 2-7 (801bp) that leads to the constitutive activation ...
Oliveira Alves Mônica Ghislaine MG Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, UNESP, Univ Estadual Paulista, 777 Engenheiro Francisco José Longo Avenue, São Dimas, São José Dos Campos, SP, 12245-000, Brazil, - - 2014
Actinic cheilitis exhibits a potential of malignant transformation in 10-20 % of cases. The objective of this study was to compare the expression of MDM2 and SUMO-1 proteins between actinic cheilitis (AC) and squamous cell carcinoma (SCC) of the lip. The sample consisted of lower lip mucosa specimens obtained from cases ...
Huang Da D Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China; Jiangxi Province Engineering Research Center of Hepatobiliary Disease, Nanchang, - - 2014
Rho-associated coiled-coil-containing protein kinase 2 (Rock2) is a downstream effector of Rho that plays an important role in the tumorigenesis and progression of hepatocellular carcinoma (HCC). Matrix metalloproteinase 2 (MMP2) is a master regulator of tumor metastasis. In this study, we investigated the collections of Rock2 and MMP2 in HCCs ...
Li Na N Department of Genetics, Medical College of Soochow University, Suzhou 215123, - - 2014
Gene fusion is among the primary processes that generate new genes and has been well characterized as potent pathway of oncogenesis. Here, by high-throughput RNA sequencing (RNA-Seq) in 9 paired human endometrial carcinoma (EC) and matched non-cancerous tissues, we obtained that chimeric TSNAX-DISC1 occurred significantly upregulated in multiple EC samples. ...
Xue Tong-Chun TC Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, P.R. - - 2014
Hepatocellular carcinoma (HCC) is a malignancy with dysregulated differentiation. However, effective differentiation therapy for HCC is lacking. Previous evidence suggests that CXCR7 is associated with the differentiation of embryonic stem cells. Here, we evaluated the potential role of CXCR7 in the differentiation of HCC. In HCC cell lines, the expression ...
Grimm Martin M Department of Oral and Maxillofacial - - 2014
Abstract Background. Apoptosis resistance is a crucial factor for the carcinogenesis of oral squamous cell carcinoma (OSCC). Methods. Expression of apoptosis resistance-related ATP-binding cassette (ABC) transporter ABCB5 [subfamily B (MDR/TAP) member 5] and DNaseX (Apo10) were analyzed in normal oral mucosa (n = 5), oral precursor lesions (simple hyperplasia, n ...
Choudhary Vivek V 1] Charlie Norwood VA Medical Center, Augusta, GA, USA [2] Department of Physiology, Georgia Regents University, Augusta, GA, USA [3] Section of Dermatology, Department of Medicine, Georgia Regents University, Augusta, GA, - - 2014
Aquaporin-3 (AQP3) is a water and glycerol channel expressed in epidermal keratinocytes. Despite many studies, controversy remains about the role of AQP3 in keratinocyte differentiation. Previously, our laboratory has shown co-localization of AQP3 and phospholipase D2 (PLD2) in caveolin-rich membrane microdomains. We hypothesized that AQP3 transports glycerol and "funnels" this ...
de Siqueira Elisa C EC Department of Oral Pathology and Medicine, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, - - 2014
Pleomorphic adenoma (PA) is the most common salivary gland neoplasm. The Hsp27 (HSPB1) is an antiapoptotic protein whose synthesis follows cytotoxic stresses and result in a transient increase in tolerance to subsequent cell injury. Although Hsp27 is expressed in a range of normal tissues and neoplasms, a wide variation in ...
Koral Kelly K Department of Pathology, University of Pittsburgh, Pittsburgh, - - 2014
Hepatocellular carcinoma (HCC) is the most commonly diagnosed form of liver cancer with high morbidity and mortality. Copy number variation analysis (CNV) of human HCC revealed that leukocyte specific protein-1 (LSP1) had the highest number of cases with CNV. LSP1, a F-actin binding protein, is expressed in hematopoietic cells and ...
Tian Yuan - - 2014
miRNA-27a has been confirmed as an important regulator in carcinogenesis and other pathological processes. Whether and how it plays a role in the laryngeal carcinoma is unknown. Mature miRNA-27a expression in laryngeal cancer was detected by qRT-PCR. Gain-of-function studies using mature miR-27a were performed to investigate cell proliferation and apoptosis ...
Fang Liang - - 2014
BackgroundMICA/B are major ligands for NK cell activating receptor NKG2D and previous studies showed that the serum level of soluble MICA (sMICA) is an independent prognostic factor for advanced human hepatocellular carcinoma. However, the correlation between cellular MICA/B expression pattern and human hepatocellular carcinoma progression has not been well explored. ...
Kirat Doaa D Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt, - - 2014
Extensive studies are published concerning the distribution of monocarboxylate transporters (MCTs) in various animal issues including ruminants; nonetheless, nothing is known about their cellular expression and localization in the ruminant pancreas. The present study was carried out to examine the expression and cellular localization of all the fourteen MCT isoforms ...
Sun Yan Y Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, - - 2014
Extensive investigations have shown that miRNAs are important regulators of epithelial-to-mesenchymal transition (EMT), mainly targeting the transcriptional repressors of E-cadherin (E-cad). Less is known about the post-transcriptional regulation of vimentin or N-cadherin (N-cad) in EMT. Our previous study identified miR-506 as a key EMT inhibitor through directly targeting the E-cad ...
Shi Feng F State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical - - 2014
Purpose: We previously revealed that calreticulin (CRT) gene is a candidate oncogene promoting cell migration and invasion and that neuropilin-1 (NRP1) is a possible effector downstream of CRT in esophageal cancer cells. This study aims to explore the mechanisms underlying the migration and invasion of esophageal cancer cells regulated by ...
Hanazono Kiwamu K Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen - - 2014
Transitional cell carcinoma (TCC), a urinary bladder tumor with high mortality, is encountered commonly in dogs. Whereas overexpression of epidermal growth factor receptor (EGFR) is associated with development of human urinary bladder cancer, information on EGFR expression in canine TCC is lacking. In this study, EGFR protein and mRNA expression ...
Pimton Pimchanok P Walailak University, Department of Biology, Thailand ; - - 2014
We investigated the effects of hypoxia on spontaneous (SP) and activin A (AA)-induced definitive endoderm (DE) differentiation of mouse embryonic stem cells (mESCs) and their subsequent differentiation into distal pulmonary epithelial cells. Spontaneous differentiation for 6 days of mESCs towards endoderm at hypoxia of 1% O2, but not at 3% ...
He Shuixiang S Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. - - 2014
Hepatocellular carcinoma (HCC) is one of the most common malignancies and accounts for ~6% of all types of human cancer worldwide, particularly in Asia. The incidence and mortality rates in the USA have also rapidly increased. Saikosaponin‑d (SSD), a saponin derivative extracted from several species of Bupleurum (Umbelliferae), possesses unique ...
Ha Yun-Sok - - 2014
The anticancer effects of selenium may be mediated by selenium-binding proteins, such as SELENBP1. The association between SELENBP1 expression levels and clinicopathologic parameters was assessed in renal cell carcinoma (RCC). SELENBP1 mRNA expression was measured with real-time quantitative polymerase chain reaction (qPCR) in 139 specimens of primary RCC and 59 ...
Attramadal Cecilie G CG Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, - - 2014
Expression of the stem cell transcription factor SOX2 is often used to imply stemness and poor prognosis in cancer. However, its role in oral squamous cell carcinoma (OSCC) is not fully elucidated. Tumour tissues from 62 patients with primary, node negative and non-metastatic OSCCs were used to evaluate SOX2 expression ...
Otsuki Tadayoshi T First Department of Surgery, Faculty of Medicine, University of Fukui, Fukui 910‑1193, - - 2014
Epithelial‑mesenchymal transition (EMT) is thought to be a key step for cancer metastasis. Using an immunohistochemical approach with gastric carcinoma tissue, we found the expression of protease‑activated receptor‑1 (PAR1), along with a metalloproteinase known to activate PAR1, were associated with poorer prognosis, compared with expression‑negative tumors, and activated PAR1 promotes gastric cancer ...
Ramírez-Salazar Eric Gustavo EG Faculty of Medicine, Universidad Autónoma de México, Mexico City, - - 2014
Pleural chronic inflammation (PP) and mesothelial hyperplasia (HP) may be critical to the development of malignant pleural mesothelioma (MPM). Nonetheless, studies searching for mechanistic links involving microRNA (miRNA) regulation among these interrelated processes have not been reported. Using PCR-Array, we identified the miRNAs expressed in pleural tissues diagnosed with MPM ...
Yuan X P XP Gastrointestinal Surgery Department, First Hospital of China Medical University, No. 92 Bei'er Road, Heping District, Shenyang, Liaoning Province, People's Republic of China, - - 2014
The major characteristics of pancreatic cancer are its excessive local invasion and early systemic dissemination. The glucose-regulated protein is over-expressed in many human cancers including pancreatic cancer and correlated with invasion and metastasis in many cancers. To investigate the effect of Grp78 on the invasion of pancreatic cancer, we used ...
Ertongur-Fauth Torsten T BRAIN AG, Darmstaedter Strasse 34-36, 64673, Zwingenberg, - - 2014
Sweating is an important physiological process to regulate body temperature in humans and various disorders are associated with dysregulated sweat formation. Primary sweat secretion in human eccrine sweat glands involves Ca(2+) -activated Cl(-) channels (CaCC). Recently, members of the TMEM16 family were identified as CaCCs in various secretory epithelia, however, ...
Park Hyun H Department of Gynecological Oncology, CHA University, Sungnam, - - 2014
Adenocarcinoma (ACA) of the uterine cervix is increasing in incidence and currently accounts for approximately 20% of all cervical malignancies. MicroRNAs (miRNAs) have been investigated as potential biomarkers of cervical cancer; however, their role in ACA remains unknown. Here, we characterized miRNA expression profiles and investigated miRNAs as diagnostic and ...
Zhu Lei L Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 116000, - - 2014
Ursodeoxycholic acid (UDCA) is widely used in clinic to treat chronic liver diseases and shown its cytoprotective effect on normal hepatocytes. This study investigated the pro-apoptotic effects of UDCA on hepatocellular carcinoma cells and the underlying molecular events in vitro. HCC cells were cultured and treated by UDCA at different ...
Tanaka Kyoko K Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan, - - 2014
Among negatively charged lipids, sulfoglycolipids are known to be expressed by specific cell populations and to be involved in their functions, including in adhesion with functional proteins, modification of ion channels and induction of cellular differentiation. Accordingly, we determined their amounts in several histologically defined types of ovarian carcinoma tissues. ...
Zhang J J Department of Thoracic Surgery, Weifang People's Hospital, Weifang, 261041, Shandong, - - 2014
MicroRNA-10b(miR-10b) has been reported to be dysregulated in some types of cancer and to play an important role in invasion and metastasis. It was previously found to be a tumor enhancer in NSCLC; however, its clinical significance in NSCLC has not been evaluated. We compared the expression levels of miR-10b ...
Singh Swarnendra S Cancer Microarray, Genes and Proteins Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110 067, - - 2014
Renal cell carcinoma (RCC) represents one of the most resistant tumors to radiotherapy and chemotherapy. Current therapies for the RCC patients are limited owing to lack of diagnosis and therapeutic treatments. Testis-specific heat-shock protein 70-2 (HSP70-2), a member of HSP70 chaperone family, has been shown to be associated with various ...
Ren L-H LH 1] Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210029, PR China [2] Department of Gastroenterology, Zhangjiagang First People's Hospital, Affiliated Hospital of Soochow University, Jiangsu Province, Suzhou 215006, PR - - 2014
Background:Dysregulated microRNAs (miRNAs) can serve as oncogenes or suppressors and are associated with many cancers, including oesophageal squamous cell carcinoma (ESCC).Methods:An alignment miRNA array was used to identify differentially expressed miRNAs in ESCC tissues. The expression of miR-183 and programmed cell death 4 (PDCD4) in oesophageal tissues from ESCC and ...
Sheshadri Namratha N Molecular Genetics and Microbiology, Stony Brook - - 2014
The serine/cysteine protease inhibitor SCCA1 (Serpin B3) is upregulated in many advanced cancers with poor prognosis, but there is limited information about whether it makes functional contributions to malignancy. Here we show that SCCA1 expression promoted oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and that SCCA1 silencing ...
Wang Mojin M Department of Gastrointestinal Surgery, Institute of Digestive Surgery, National Key Laboratory of - - 2014
The aim of this study was to investigate the role of PKA RIα/AKAP10 signaling pathway in colorectal cancer (CRC). The AKAP10 expression at the mRNA and protein level have been analyzed in colon cancer cell lines, primary CRCs and matched normal mucosa samples, and compared in accordance with specific clinicopathological ...
Zhang Qi - - 2014
To study the effects of chronic ischemia on bladder purinoceptors. A close correlation between bladder ischemia and lower urinary tract symptoms has been reported. Purinoceptors contribute to important aspects of bladder function including sensation, neural signaling, and voiding contraction. Our goal was to examine purinoceptors expression in the ischemic overactive ...
Hsu Fei-Ting FT Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Bei-tou, Taipei, Taiwan, - - 2014
Background/Aim: Although anticancer effects of sorafenib on renal, liver and colon carcinomas are well-known, its combination effect with ionizing radiation on oral squamous cell carcinoma (OSCC) is unclear. Herein human SAS cells, an OSCC cell line, were used in order to elucidate this combination effect. Materials and Methods: Both SAS ...
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