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Li Ying Y Center of Gerontology and Geriatrics, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. - - 2014
The aim of the present study was to investigate the function of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and cyclooxygenase-2 (COX-2) in angiogenesis and their association with the prognosis of non-small cell lung cancer (NSCLC). Using immunohistochemical staining, the expression of 15-PGDH and COX-2, and the microvessel density (MVD) levels were evaluated in ...
Li Li-Ping LP Department of Gastroenterology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. - - 2014
The present study aimed to identify the association between microRNA (miR/miRNA)-449a, the cyclin-dependent kinase (CDK)6 protein and gastric carcinoma, and discuss the effect of miR-449a on the expression of the CDK6 protein. Quantitative (q)PCR and western blot analysis were used to analyze the expression of the miR-449a and the CDK6 ...
Fang Liang - - 2014
BackgroundMICA/B are major ligands for NK cell activating receptor NKG2D and previous studies showed that the serum level of soluble MICA (sMICA) is an independent prognostic factor for advanced human hepatocellular carcinoma. However, the correlation between cellular MICA/B expression pattern and human hepatocellular carcinoma progression has not been well explored. ...
Choudhary Vivek V 1] Charlie Norwood VA Medical Center, Augusta, GA, USA [2] Department of Physiology, Georgia Regents University, Augusta, GA, USA [3] Section of Dermatology, Department of Medicine, Georgia Regents University, Augusta, GA, - - 2014
Aquaporin-3 (AQP3) is a water and glycerol channel expressed in epidermal keratinocytes. Despite many studies, controversy remains about the role of AQP3 in keratinocyte differentiation. Previously, our laboratory has shown co-localization of AQP3 and phospholipase D2 (PLD2) in caveolin-rich membrane microdomains. We hypothesized that AQP3 transports glycerol and "funnels" this ...
de Siqueira Elisa C EC Department of Oral Pathology and Medicine, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, - - 2014
Pleomorphic adenoma (PA) is the most common salivary gland neoplasm. The Hsp27 (HSPB1) is an antiapoptotic protein whose synthesis follows cytotoxic stresses and result in a transient increase in tolerance to subsequent cell injury. Although Hsp27 is expressed in a range of normal tissues and neoplasms, a wide variation in ...
Kirat Doaa D Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt, - - 2014
Extensive studies are published concerning the distribution of monocarboxylate transporters (MCTs) in various animal issues including ruminants; nonetheless, nothing is known about their cellular expression and localization in the ruminant pancreas. The present study was carried out to examine the expression and cellular localization of all the fourteen MCT isoforms ...
Sun Yan Y Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, - - 2014
Extensive investigations have shown that miRNAs are important regulators of epithelial-to-mesenchymal transition (EMT), mainly targeting the transcriptional repressors of E-cadherin (E-cad). Less is known about the post-transcriptional regulation of vimentin or N-cadherin (N-cad) in EMT. Our previous study identified miR-506 as a key EMT inhibitor through directly targeting the E-cad ...
Shi Feng F State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical - - 2014
Purpose: We previously revealed that calreticulin (CRT) gene is a candidate oncogene promoting cell migration and invasion and that neuropilin-1 (NRP1) is a possible effector downstream of CRT in esophageal cancer cells. This study aims to explore the mechanisms underlying the migration and invasion of esophageal cancer cells regulated by ...
Hanazono Kiwamu K Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen - - 2014
Transitional cell carcinoma (TCC), a urinary bladder tumor with high mortality, is encountered commonly in dogs. Whereas overexpression of epidermal growth factor receptor (EGFR) is associated with development of human urinary bladder cancer, information on EGFR expression in canine TCC is lacking. In this study, EGFR protein and mRNA expression ...
Pimton Pimchanok P Walailak University, Department of Biology, Thailand ; - - 2014
We investigated the effects of hypoxia on spontaneous (SP) and activin A (AA)-induced definitive endoderm (DE) differentiation of mouse embryonic stem cells (mESCs) and their subsequent differentiation into distal pulmonary epithelial cells. Spontaneous differentiation for 6 days of mESCs towards endoderm at hypoxia of 1% O2, but not at 3% ...
Ha Yun-Sok - - 2014
The anticancer effects of selenium may be mediated by selenium-binding proteins, such as SELENBP1. The association between SELENBP1 expression levels and clinicopathologic parameters was assessed in renal cell carcinoma (RCC). SELENBP1 mRNA expression was measured with real-time quantitative polymerase chain reaction (qPCR) in 139 specimens of primary RCC and 59 ...
He Shuixiang S Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. - - 2014
Hepatocellular carcinoma (HCC) is one of the most common malignancies and accounts for ~6% of all types of human cancer worldwide, particularly in Asia. The incidence and mortality rates in the USA have also rapidly increased. Saikosaponin‑d (SSD), a saponin derivative extracted from several species of Bupleurum (Umbelliferae), possesses unique ...
Attramadal Cecilie G CG Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, - - 2014
Expression of the stem cell transcription factor SOX2 is often used to imply stemness and poor prognosis in cancer. However, its role in oral squamous cell carcinoma (OSCC) is not fully elucidated. Tumour tissues from 62 patients with primary, node negative and non-metastatic OSCCs were used to evaluate SOX2 expression ...
Otsuki Tadayoshi T First Department of Surgery, Faculty of Medicine, University of Fukui, Fukui 910‑1193, - - 2014
Epithelial‑mesenchymal transition (EMT) is thought to be a key step for cancer metastasis. Using an immunohistochemical approach with gastric carcinoma tissue, we found the expression of protease‑activated receptor‑1 (PAR1), along with a metalloproteinase known to activate PAR1, were associated with poorer prognosis, compared with expression‑negative tumors, and activated PAR1 promotes gastric cancer ...
Yuan X P XP Gastrointestinal Surgery Department, First Hospital of China Medical University, No. 92 Bei'er Road, Heping District, Shenyang, Liaoning Province, People's Republic of China, - - 2014
The major characteristics of pancreatic cancer are its excessive local invasion and early systemic dissemination. The glucose-regulated protein is over-expressed in many human cancers including pancreatic cancer and correlated with invasion and metastasis in many cancers. To investigate the effect of Grp78 on the invasion of pancreatic cancer, we used ...
Ertongur-Fauth Torsten T BRAIN AG, Darmstaedter Strasse 34-36, 64673, Zwingenberg, - - 2014
Sweating is an important physiological process to regulate body temperature in humans and various disorders are associated with dysregulated sweat formation. Primary sweat secretion in human eccrine sweat glands involves Ca(2+) -activated Cl(-) channels (CaCC). Recently, members of the TMEM16 family were identified as CaCCs in various secretory epithelia, however, ...
Park Hyun H Department of Gynecological Oncology, CHA University, Sungnam, - - 2014
Adenocarcinoma (ACA) of the uterine cervix is increasing in incidence and currently accounts for approximately 20% of all cervical malignancies. MicroRNAs (miRNAs) have been investigated as potential biomarkers of cervical cancer; however, their role in ACA remains unknown. Here, we characterized miRNA expression profiles and investigated miRNAs as diagnostic and ...
Zhu Lei L Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 116000, - - 2014
Ursodeoxycholic acid (UDCA) is widely used in clinic to treat chronic liver diseases and shown its cytoprotective effect on normal hepatocytes. This study investigated the pro-apoptotic effects of UDCA on hepatocellular carcinoma cells and the underlying molecular events in vitro. HCC cells were cultured and treated by UDCA at different ...
Tanaka Kyoko K Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan, - - 2014
Among negatively charged lipids, sulfoglycolipids are known to be expressed by specific cell populations and to be involved in their functions, including in adhesion with functional proteins, modification of ion channels and induction of cellular differentiation. Accordingly, we determined their amounts in several histologically defined types of ovarian carcinoma tissues. ...
Zhang J J Department of Thoracic Surgery, Weifang People's Hospital, Weifang, 261041, Shandong, - - 2014
MicroRNA-10b(miR-10b) has been reported to be dysregulated in some types of cancer and to play an important role in invasion and metastasis. It was previously found to be a tumor enhancer in NSCLC; however, its clinical significance in NSCLC has not been evaluated. We compared the expression levels of miR-10b ...
Singh Swarnendra S Cancer Microarray, Genes and Proteins Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110 067, - - 2014
Renal cell carcinoma (RCC) represents one of the most resistant tumors to radiotherapy and chemotherapy. Current therapies for the RCC patients are limited owing to lack of diagnosis and therapeutic treatments. Testis-specific heat-shock protein 70-2 (HSP70-2), a member of HSP70 chaperone family, has been shown to be associated with various ...
Ren L-H LH 1] Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210029, PR China [2] Department of Gastroenterology, Zhangjiagang First People's Hospital, Affiliated Hospital of Soochow University, Jiangsu Province, Suzhou 215006, PR - - 2014
Background:Dysregulated microRNAs (miRNAs) can serve as oncogenes or suppressors and are associated with many cancers, including oesophageal squamous cell carcinoma (ESCC).Methods:An alignment miRNA array was used to identify differentially expressed miRNAs in ESCC tissues. The expression of miR-183 and programmed cell death 4 (PDCD4) in oesophageal tissues from ESCC and ...
Sheshadri Namratha N Molecular Genetics and Microbiology, Stony Brook - - 2014
The serine/cysteine protease inhibitor SCCA1 (Serpin B3) is upregulated in many advanced cancers with poor prognosis, but there is limited information about whether it makes functional contributions to malignancy. Here we show that SCCA1 expression promoted oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and that SCCA1 silencing ...
Wang Mojin M Department of Gastrointestinal Surgery, Institute of Digestive Surgery, National Key Laboratory of - - 2014
The aim of this study was to investigate the role of PKA RIα/AKAP10 signaling pathway in colorectal cancer (CRC). The AKAP10 expression at the mRNA and protein level have been analyzed in colon cancer cell lines, primary CRCs and matched normal mucosa samples, and compared in accordance with specific clinicopathological ...
Zhang Qi - - 2014
To study the effects of chronic ischemia on bladder purinoceptors. A close correlation between bladder ischemia and lower urinary tract symptoms has been reported. Purinoceptors contribute to important aspects of bladder function including sensation, neural signaling, and voiding contraction. Our goal was to examine purinoceptors expression in the ischemic overactive ...
Hsu Fei-Ting FT Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Bei-tou, Taipei, Taiwan, - - 2014
Background/Aim: Although anticancer effects of sorafenib on renal, liver and colon carcinomas are well-known, its combination effect with ionizing radiation on oral squamous cell carcinoma (OSCC) is unclear. Herein human SAS cells, an OSCC cell line, were used in order to elucidate this combination effect. Materials and Methods: Both SAS ...
Hu Zhongliang Z Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia; Department of Pathology, Xiangya Hospital, Central South University, Changsha, China; Department of Pathology, Xiangya Medical School, Central South University, Changsha, - - 2014
To understand the mechanism of frequent and early lymph node metastasis in high-risk human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), this study investigated whether β-catenin is regulated by the HPV oncoprotein and contributes to OPSCC metastasis. Expression levels of p16, β-catenin, and epidermal growth factor receptor (EGFR) were examined ...
Winuthayanon Wipawee - - 2014
Estrogens exert their activity through estrogen receptor alpha (ERalpha) to stimulate hypertrophy and hyperplasia in the uterus. A uterine epithelial ERα conditional knockout mouse model (Wnt7a(Cre+);Esr1(f/f) or cKO) demonstrated that ER&alpha in the epithelial cells was dispensable for an initial uterine proliferative response to 17beta-estradiol (E2), but required for subsequent ...
Ma Li L The Hepatosplenic Surgery Center, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China; Department of Urologic Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, - - 2014
Sorafenib is the approved systemic drug of choice for advanced hepatocellular carcinoma (HCC), but has demonstrated limited benefits because of drug resistance. 2-methoxyestradiol (2ME2) has been shown to be a promising anticancer drug against various types of cancers and acts by dysregulating hypoxia-inducible factor (HIF)-1. Hypoxic cancer cells are extremely ...
Yi Sang Ah SA Research Center for Epigenome Regulation, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi 440‑746, Republic of - - 2014
Heterochromatin protein 1 (HP1) is an epigenetic modifier of gene regulation and chromatin packing via binding to trimethylated histone H3 lysine 9 (H3K9). HP1 plays an important role in gene activation as well as gene repression in heterochromatin and euchromatin. However, the role of individual HP1 proteins in human diseases remains elusive. Here, we ...
Ivan Michael E ME Department of Neurological Surgery, University of California, San Francisco, CA, USA, - - 2014
Epidermal growth factor (EGF) module-containing mucin-like receptor 2 (EMR2) is a member of the seven span transmembrane adhesion G-protein coupled receptor subclass. This protein is expressed in a subset of glioblastoma (GBM) cells and associated with an invasive phenotype. The expression pattern and functional significance of EMR2 in low grade ...
Lawrenson Kate K Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, - - 2014
Epithelial ovarian cancer is still considered the most lethal gynecological malignancy and improved early detection of ovarian cancer is crucial to improving patient prognoses. To address this need, we tested whether candidate EOC biomarkers can be identified using three-dimensional in vitro models. We quantified changes in the abundance of secreted ...
Xu Lijun - - 2014
Aberrant expression of miR-1 has been implicated in various cancers. However, the mechanisms underlying the role of miR-1 in CRC progression still have not been clarified clearly. Here, we showed the decreased expression of miR-1 in colorectal carcinoma (CRC) tissues and cell lines. Ectopic introduction of miR-1 suppressed cell proliferation ...
Faria André M AM Unidade de Suprarrenal & Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, - - 2014
LIN28 control cells reprogramming and pluripotency mainly through miRNA regulation and has been overexpressed in many advanced cancers. In this study, we evaluated the prognostic role of LIN28 and its regulatory miRNAs in a large cohort of adrenocortical tumors (ACTs). LIN28 protein expression was assessed in 266 adults ACTs (78 ...
Ge Zhong Z Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, - - 2014
The molecular regulation of growth of hepatocellular carcinoma (HCC) is yet to be fully clarified. Here we found a significantly higher ratio of phosphorylated β-catenin (phos-β-cat) to β-catenin (β-cat) as an indicator of an activated Wnt signaling, with significantly higher levels of c-myc and transcription factor activating protein-4 (AP-4) and ...
Podmaniczky Eszter E Department of Pulmonology, Semmelweis University, Diosarok u. 1/c, Budapest, H-1125, - - 2014
We have already demonstrated in a small cohort of 17 non-small cell lung cancer patients that ERCC1 (excision repair cross-complementation group 1) protein expression decreased after platinum-based treatment, however, certain clinicopathological parameters, such as histologic subtypes, ERCC1 expression scores, chemotherapeutic combinations, response rate, gender and smoking history were not analyzed. ...
Alves Venâncio A VA Venâncio A Alves, Aloisio Felipe-Silva, Adhemar Longatto-Filho, Laboratory of Medical Investigation (LIM) 14, Department of Pathology, University of São Paulo School of Medicine, São Paulo, SP 1246-903, - - 2014
To assess the immunoexpression of hypoxia-related markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma (HCC). From a total of 5836 autopsies performed at the Pathology Department - University of Sao Paulo School of Medicine Hospital - from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity ...
Zhao Yurong Y Department of Obstetrics and Gynecology, FuXing Hospital, Capital Medical University, Beijing, - - 2014
Aim: To observe the expression of aquaporin-2 (AQP2) in human ectocervical-vaginal epithelial cells (hECEs). Methods: The study included 75 females who underwent hysterectomy for benign pelvic lesions. They were divided into three groups according to menstrual states: 28 cases in the normal menstrual group, 24 cases in the perimenopausal group, ...
Pal Deeksha D Department of Biochemistry, PGIMER, Chandigarh, - - 2014
Zinc is an indispensable trace element which is vital for the functioning of numerous cellular processes like cell replication and growth. Cellular zinc homeostasis is tightly regulated by zinc transporters involved in zinc influx and efflux processes. Notwithstanding, the association of zinc transporters with the aggressiveness of cancer, especially renal ...
Luan Fang F Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China; Department of Clinical Laboratory, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, Shandong 250021, PR - - 2014
Glypican 3 (GPC3) has been paid particular attention owing to its potential as diagnosis marker for hepatocellular carcinoma (HCC). Identifying the mechanisms regulating the reactivation of GPC3 in HCC appears to be clinically meaningful. Previous study identified zinc-fingers and homeoboxes 2 (ZHX2) as transcriptional factor responsible for postnatal repression of ...
Song Na-Young NY Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, South - - 2014
Multiple lines of compelling evidence from clinical and population-based studies supports that hyperinsulinemia often accompanying obesity-associated insulin insensitivity promotes colon carcinogenesis. Insulin can acetylate, thereby activating sterol regulator element-binding protein 1 (SREBP-1), a prime transcription factor responsible for expression of genes involved in lipogenesis. Moreover, SREBP-1 upregulates cyclooxygenase-2 (COX-2), a ...
Yan Xue-Bing XB Department of Surgery, Sixth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200233, P.R. - - 2014
Y‑box binding protein‑1 (YB‑1) has been identified as an oncoprotein in various malignancies. The aim of this study was to investigate the biological role of YB‑1 and its association with epithelial‑to‑mesenchymal transition (EMT) in colorectal cancer (CRC). The expression of YB‑1 and three EMT‑related proteins (E‑cadherin, N‑cadherin and vimentin) was ...
Li Hui H College of Animal Science and Technology, Northwest A&F University, Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, - - 2014
The signal transducer and activator of transcription 5a (Stat5a) modulates genes involved in proliferation and survival and plays pivotal roles in regulating the function of the mammary gland during pregnancy, lactation, and involution. However, there is little information about the effects of Stat5a on apoptosis of goat mammary gland epithelial ...
Wang B-J BJ Department of Laboratory Medicine, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, People's Republic of - - 2014
Insulin-like growth factor 2 (IGF-2) mRNA-binding protein 3 (IMP3) is overexpressed in pancreatic cancer, while remaining undetectable in the normal pancreas, indicating its important role in pancreatic cancer pathogenesis. The role of IMP3 in pancreatic carcinogenesis has not been fully understood. The main goal of this study was to probe ...
Wang Dandan D Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, 110004, - - 2014
Human antigen R (HuR) is an mRNA-binding factor that belongs to the embryonic lethal abnormal vision/Hu protein family which may function as a tumor maintenance gene in a variety of carcinomas. However, there is no study to analyze HuR expression in endometrial carcinoma. Here, we investigated the expression of HuR ...
Kanda Mitsuro M Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, - - 2014
Identification of novel genetic and epigenetic alterations is required for optimal stratification of patients with hepatocellular carcinoma (HCC) at risk for recurrence and adverse prognosis. Coenzyme Q10 (CoQ10), which mediates apoptosis, is synthesized by prenyl diphosphate synthase subunit 2 (PDSS2). In the present study we evaluated the clinical significance and ...
Fang Yang Y Department of Hepatobiliary Surgery, Fuzong Clinical Medical College of Fujian Medical University , Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Fujian, China - - 2014
Rho GDP dissociation inhibitor (GDI) beta, (RhoGDI2), has been identified as a proto-oncogene that is upregulated in human cancers, but the role of RhoGDI2 in hepatocellular carcinoma (HCC) remains unclear. In the present study, we investigated the RhoGDI2 expression level in HCC tissues and the function of RhoGDI2 in HCC ...
Song Shangqing S Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, P.R. - - 2014
To investigate the expression pattern of a novel long noncoding ribonucleic acid (RNA), RCCRT1, in renal cell carcinoma (RCC) tissues among the patients with various clinicopathologic features and to detect the role of RCCRT1 in migration and invasion of RCC in vitro. We found out a novel long noncoding RNA, RCCRT1, ...
Sun Zhifeng Z Department of Otolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Berlin, - - 2014
MicroRNAs (miRs) are small non-coding RNAs that regulate the translation of many genes in normal and cancer cells where they are frequently dysregulated promoting tumor progression. Several studies have illustrated the potential of manipulating miR expression in cancer research and therapy. The aim of the present study was to investigate ...
Díaz-López Antonio A Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, - - 2014
Cell plasticity is emerging as a key regulator of tumor progression and metastasis. During carcinoma dissemination epithelial cells undergo Epithelial to Mesenchymal Transition (EMT) processes characterized by the acquisition of migratory/invasive properties, while the reverse, Mesenchymal to Epithelial Transition (MET) process, is also essential for metastasis outgrowth. Different transcription factors, ...
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