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Li Wenping W From the Departments of Pathology - - 2014
Uroplakin (UP) II and UPIII are highly specific immunohistochemical markers for urothelial differentiation. Here we studied the sensitivity of UPII and UPIII in conventional and variant urothelial carcinomas (UCs). Immunohistochemical staining for UPII and UPIII was performed on tissue microarray slides, including 105 conventional bladder UCs (BUCs), 90 upper urinary ...
Li G-L GL Fisheries College, Guangdong Ocean University, Zhanjiang, 524088, China; Key Laboratory of Aquaculture in South China Sea for Aquatic Economic Animal of Guangdong Higher Education Institutes, Guangdong Ocean University, Zhanjiang, 524088, - - 2014
In this study, the complete foxl2 complementary (c)DNA sequence was isolated by simple modular-architecture research tool (SMART)er rapid amplification of cDNA ends (RACE). Two year-old female spotted scat, Scatophagus argus, were reared at different temperatures (23, 26 and 29° C) for 6 weeks, or fed with different concentrations of dietary ...
Dunn Lorna J LJ Northern Oesophago-Gastric Cancer Unit, Royal Victoria Infirmary, Queen Victoria Road, Newcastle-upon-Tyne, NE1 4LP, UK, - - 2014
Trefoil proteins are believed to have an important role in mucosal protection and repair in the gastrointestinal tract. They are well recognized in Barrett's esophagus and considered a potential biomarker for the condition. Metaplasia occurring in the esophageal remnant after esophagectomy is a human model for the early stages of ...
Figueira Ana - - 2014
BackgroundCadherins are calcium-dependent cell-to-cell adhesion glycoproteins playing a critical role in the formation and maintenance of normal tissue architecture. In normal mammary gland, E-cadherin is expressed by luminal epithelial cells, while P-cadherin is restricted to myoepithelial cells. Changes in the expression of classical E- and P-cadherins have been observed in ...
Tsang Felice Ho-Ching FH State Key Laboratory for Liver Research and Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, - - 2014
Hepatocellular carcinoma (HCC) is one of the most common human cancers. Recently, emerging evidence has suggested the role of long non-coding RNAs (lncRNAs) in human carcinogenesis. In this study we aimed to investigate the expression and functional implications of lncRNAs in human HCC. 88 well-annotated lncRNAs were profiled in primary ...
Zhang Shulin - - 2014
BackgroundThe Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in several types of cancer including mesothelioma. Protein kinase CK2 affects several cell signaling pathways through the mechanism of phosphorylation.MethodsProtein and mRNA levels of CK2¿ and Gli1 were tested by quantitative RT-PCR and ...
Lin Li - - 2014
Hepatocyte nuclear factor-3beta (HNF-3beta) plays a critical role in hepatocyte differentiation and controls liver-specific gene expression during the development of hepatocellular carcinoma (HCC), but the molecular basis of this process has not been fully elucidated. microRNAs (miRNAs) are powerful, post-transcriptional regulators of gene expression. Whether miRNAs can impact the effects ...
Feng Ming-Xiang MX 1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China - - 2014
Objective: To explore the expression of cyclophilin A (CypA) in esophageal tissues and its clinical significance. Method: Expression of CypA was detected in 236 esophageal cancer tissues and 236 normal tissues by using an immunohistochemical method, and the relationship between CypA expression and clinical outcomes was observed. Results: There were ...
Lei Mingzhu M College of Veterinary Medicine of Northwest A&F University, Yangling, Shaanxi, - - 2014
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) interactions affect the regulation of cytotoxic/immunotrophic pathways that are themselves under control of IL-18. The effect of Fn14 on regulation of endometrium IL-18 expression, however, remains unclear. The aim was to determine the mode of ovarian steroid action ...
Kamphues Carsten C From the *Department of General, Visceral and Transplantation Surgery, and †Institute of Pathology, Charité University Hospital, Berlin; ‡Institute of Pathology, University Hospital Heidelberg; and §National Center for Tumor Diseases, Heidelberg, - - 2014
Recently, aberrations in the gene encoding for ataxia-telangiectasia-mutated (ATM) protein kinase have been reported for pancreatic ductal adenocarcinomas (PDAC). These findings argue that ATM deficiency may play a role during carcinogenesis. Therefore, in this study, we investigated the clinical relevance of ATM expression and ATM activation in PDAC. Both ATM ...
Yuan Taize T Department of Radiotherapy, Affiliated Cancer Hospital of Guangzhou Medical University, No. 78, Hengzhigang Road, Yuexiu District, Guangzhou, 510095, Guangdong, - - 2014
Metastasis-associated protein 1 (MTA1) is related to tumour metastasis and poor prognosis in various human cancers. The aim of this study was to investigate the expression of MTA1 in nasopharyngeal carcinoma (NPC) and explore the prognostic value of MTA1 in NPC patients. The expression of MTA1 in 136 human NPC ...
Boscia Francesca F Dipartimento di Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, Università di Napoli "Federico II, 80131, Naples, - - 2014
The G protein-coupled estrogen receptor (GPR30) is suggested to be involved in non-nuclear estrogen signalling and is expressed in a variety of hormone dependent cancer entities. It is well established that oestrogens are involved in pathological germ cell proliferation including testicular germ cell tumours. This study was performed to further ...
Hamamoto Junko J Department of Pulmonary Medicine, School of Medicine, Keio - - 2014
We identified TMPRSS4 (transmembrane protease, serine 4) as a putative, druggable target by screening surgically resected samples from 90 Japanese non-small lung cancer (NSCLC) patients using cDNA microarray. TMPRSS4 has two druggable domains and up-regulated in 94.5% of the lung cancer patient specimens. Interestingly, we found that TMPRSS4 expression was ...
Li Hai-Feng HF Department of Pathology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P.R. - - 2014
The aim of the present study was to investigate the expression and function of metastasis-associated in colon cancer 1 (MACC1) in tongue squamous cell carcinoma (TSCC) and its relationship with the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147). Levels of MACC1 and EMMPRIN expression were analyzed in 65 paraffin‑embedded ...
Li Chunyan C Department of Oncology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. - - 2014
v-ets erythroblastosis virus E26 oncogene homolog 1 (ETS-1) plays crucial roles in a spectrum of malignancies. ETS-1 has gained attention in cancer research for its importance in cell migration, invasion and proliferation. In the present study, we focused on the effect of ETS-1 on epithelial-mesenchymal transition (EMT), which is characterized by ...
He Bin B Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. - - 2014
The increasing expression of microRNA‑155 (miR‑155) and decreasing expression of RNA‑binding protein quaking (QKI) in colon cells have been observed previously. In this study, we attempted to establish the correlation between miR‑155 and QKI. In addition, we assessed whether the expression of miR‑155 and QKI is linked to the proliferation ...
Xue Jing J Department of Epidemiology, Public Health School of Central South University, Changsha, 410078, China, - - 2014
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. P21-activated kinase 4 (PAK4) has been identified as an oncogenic protein in a variety of cancers. However, the contribution and regulation of PAK4 in HCC remain poorly understood. In the present study, we found that inhibition of PAK4 expression ...
Sperandio Felipe F FF Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, 37130-000, MG, Brazil; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA. sperandio@usp.br, - - 2014
Low-level laser therapy (LLLT) has been extensively employed to improve epithelial wound healing, though the exact response of epithelium maturation and stratification after LLLT is unknown. Thus, this study aimed to assess the in vitro growth and differentiation of keratinocytes (KCs) and in vivo wound healing response when treated with ...
Hwang David H DH Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, - - 2014
Myc family members are important contributors to oncogenesis in a variety of tumors. Identification of therapeutic targets are needed in small cell lung carcinoma (SCLC), an aggressive disease with limited treatment options. Sequencing studies have identified MYC amplification in 2-7% of SCLC. We hypothesized that immunohistochemistry (IHC) will detect Myc ...
Dong Liangpeng L Department of General Surgery, the First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, 453100, - - 2014
More and more evidence has demonstrated that astrocyte elevated gene-1 (AEG-1) is tightly associated with progression, metastasis, and unfavorable prognosis in many malignancies. However, the potential biological role of AEG-1 in gastric carcinoma (GC) has not been thoroughly delineated. In the current study, we found that AEG-1 mRNA and protein ...
Xuan Xaioyan X Department of Pathology, The First Affiliated Hospital and Key Laboratory of Tumor Pathology, Zhengzhou University School of Medicine, Zhengzhou, Henan, - - 2014
Stat3 alters the expression of its downstream genes and is associated with tumor invasion and metastasis in several human cancers. Its role in esophageal squamous cell carcinoma (ESCC) has not been well characterized. We examined the tumor sections of 100 cases of ESCC by immunohistochemistry and observed significant overexpression of ...
Hirata Hidenari H Department of Surgery, Kyushu University Beppu Hospital, Beppu, - - 2014
Downregulation of paired related homeobox 1 (PRRX1) is associated with the acquisition of cancer stem cell (CSC)-like properties and poor prognosis in cancers. The purpose of this study is to clarify the role of PRRX1 expression in predicting prognosis and mediating CSC-like properties in hepatocellular carcinoma (HCC). The association between ...
Kanda Mitsuro M Department of Gastroenterological Surgery (Surgery Ⅱ), Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, - - 2014
Although the B‑cell translocation gene 1 (BTG1) plays an important role in apoptosis and negatively regulates cell proliferation, BTG1 expression in hepatocellular carcinoma (HCC) has not been evaluated. In this study expression analysis of BTG1 was conducted to clarify the role of BTG1 in the initiation of HCC carcinogenesis and progression. BTG1 mRNA ...
Yang Qing-Qing QQ Union School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, - - 2014
Alterations in the expression of several long non-coding RNAs (lncRNAs) have been found in primary nasopharyngeal carcinoma (NPC). However, the effect of lncRNA expression on primary NPC as well as the molecular mechanism of lncRNA remains vague. This study was to identify differentially expressed lncRNAs involved in NPC on a ...
Liu Zhen - - 2014
Stromal cell-derived factor 1 (SDF-1) is a chemokine that is expressed in some cancer cells and is involved in tumor cell migration and metastasis. CXCR7, a novel receptor for SDF-1, has been identified recently. Research has demonstrated that SDF-1/CXCR7 interaction could play an important role in cancer progression. In this ...
Jiang W W State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Fudan University, Shanghai, - - 2014
Activation of cyclin E1, a key regulator of the G1/S cell-cycle transition, has been implicated in many cancers including hepatocellular carcinoma (HCC). Although much is known about the regulation of cyclin E1 expression and stability, its post-transcriptional regulation mechanism remains incompletely understood. Here, we report that nuclear factor 90 (NF90), ...
Matsuo Yuji Y Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, Honjo 1-1-1, Chuou-ku, Kumamoto, 860-8556, - - 2014
Ovarian clear cell adenocarcinoma (CCA) has been believed to be a lethal histological subtype of an epithelial ovarian adenocarcinoma (EOA); its precursor has been assumed to be endometriosis. However, it has been reported that CCAs occasionally exhibit different clinical behaviors, suggesting that CCAs might not belong to a single category. ...
Tang Xiao Bing XB Department of Pediatric Surgery, Shengjing Hospital, China Medical University, Shenyang, - - 2014
Purpose: The aim of this study was to determine the expression of Cdx4 (caudal-type homeobox gene-4) during anorectal development in normal and ethylenethiourea (ETU)-induced anorectal malformation (ARM) embryos with a view to establishing the possible role of Cdx4 in ARM pathogenesis. Materials and Methods: ARM was induced by ETU on ...
Kim Min Jong MJ Department of Pathology, Yeungnam University College of Medicine, Daegu, Republic of - - 2014
To investigate AT-rich interactive domain-containing protein 1A (ARID1A) and p53 expression in small intestine carcinoma (SIC) and to determine its prognostic significance. Immunohistochemical staining for ARID1A and p53 was performed in 178 SICs using a tissue microarray (TMA). Loss of or low ARID1A expression was observed in 36 (20.2%) and ...
Shi Mo M Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, - - 2014
The inactivation of RUNX3 in various cancers has been reported while the expression of RUNX3 on protein level in esophageal squamous cell carcinoma (ESCC) and its relationship with pathological parameters and prognosis still remained unclear. In this study, we examined the expression of RUNX3 in 158 ESCC samples and 20 ...
Wang Yumin Y Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. - - 2014
Long‑chain non‑coding RNAs (lncRNAs) have been shown to be involved in the development and progression of non‑small cell lung cancer (NSCLC). However, the roles of lncRNAs in NSCLC are not well understood. In this study, a high‑throughput microarray was used to compare the lncRNA and mRNA expression profiles in NSCLC ...
Seidelin Jakob Benedict JB Herlev Hospital, University of Copenhagen - - 2014
Identification of pathways involved in wound healing is important for understanding the pathogenesis of various intestinal diseases. Cellular inhibitor of apoptosis protein 2 (cIAP2) regulates proliferation and migration in non-epithelial cells and is expressed in human colonocytes. The aim of the study was to investigate the role of cIAP2 for ...
Ma Jin-An JA Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. - - 2014
The aim of the present study was to investigate the effect of downregulation of the c‑Met gene on signal transduction and apoptosis in gastric cancer MKN‑45 cells; furthermore, the study aimed to determine whether altered c‑Met gene expression affected MKN‑45 sensitivity to gefitinib. Three c‑Met‑specific small interfering RNAs (siRNAs) were ...
Lu Hongsheng H Department of Pathology, Taizhou Central Hospital, Taizhou, 318000, Zhejiang, - - 2014
To explore the relationship between Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3(MEKK3) and cell apoptosis, clinicopathology and prognosis, we characterize the expression of MEKK3, survivin and stat3 in renal clear cell carcinoma (RCCC). The expressions were measured by RT-PCR and Western blot from 15 cases of RCCC and 15 ...
Dai Ting T Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, China; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University; Department of biotechnology, GuangZhou Medical - - 2014
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies, in which NF-κB pathway plays an important role and is constitutively activated. Better understanding of the molecular pathogenesis of HCC and NF-κB pathway are needed to improve patient outcomes. Herein, we identified an unappreciated protein involved in NF-κB induced activation, ...
Wang Yunhua Y Department of Anesthesiology, The First People's Hospital of Foshan and Foshan Hospital of Sun Yat‑Sen University, Foshan, Guangdong 528000, P.R. - - 2014
The aim of the present study was to investigate the in vitro effects of ulinastatin (UTI) on the proliferation, invasion, apoptosis, expression and distribution of high mobility group box 1 (HMGB1) and the expression of nuclear factor κB (NF‑κB) in human colon carcinoma LoVo cells. The cells were divided into control (untreated), UTI1 ...
Lee Heejeong - - 2014
MicroRNA (miRNA) expression is known to be deregulated in cervical carcinomas. However, no data is available about the miRNA expression pattern for the minimal deviation adenocarcinoma (MDA) of uterine cervix. We sought to detect deregulated miRNAs in MDA in an attempt to find the most dependable miRNA or their combinations ...
Chen You-Fang YF State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, No. 651, Dongfeng Road East, Guangzhou, 510060, Guangdong Province, - - 2014
To investigate the clinical prognostic value of protein tyrosine kinase 6 (PTK6) in patients with esophageal squamous cell carcinoma (ESCC), quantitative RT-PCR and Western blotting were utilized to measure the mRNA and protein expression levels of PTK6 in 29 and eight pairs of ESCC and peritumoral normal esophageal tissues, respectively. ...
Elkady Ayman I AI Ayman I Elkady, Osama A Abu-Zinadah, Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi - - 2014
To investigate the effects of extracts from Rhazya stricta (R. stricta) and Zingiber officinale (Z. officinale) on human colorectal cancer cells. Human colorectal cancer cells (HCT116) were subjected to increasing doses of crude alkaloid extracts from R. stricta (CAERS) and crude flavonoid extracts from Z. officinale (CFEZO). Cells were then ...
Sun Jiangtao J Institute of Cancer Research, The First Affiliated Hospital of Henan University of Science Technology, Luoyang, Henan 471003, P.R. - - 2014
microRNAs (miRNAs) have been demonstrated to be important gene regulators with critical roles in diverse biological processes, including tumorigenesis. Accumulating evidence suggests that miR‑338-3p exerts a tumor suppressor role and is downregulated in tumors, including gastric cancer and colorectal carcinoma. However, the role of miR‑338-3p in lung cancer, particularly non‑small‑cell ...
Song Zhifang Z Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. - - 2014
The aim of the current study was to analyze the differential microRNA (miRNA) expression profiles of human epidermal stem cells (ESCs) and differentiated keratinocytes. Enzyme digestion was used in combination with rapid adhesion to collagen IV to isolate primary human ESCs and differentiated keratinocytes, from which total RNA was extracted. Fluorescence ...
Bai Jing J Department of Otolaryngology, Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai; Department of Otolaryngology, The First People's Hospital of Foshan City, - - 2014
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by significant goblet hyperplasia and mucus hypersecretion. However, the molecular mechanism underlying mucin overexpression in CRSwNP has not been well characterized. This study sought to assess the expression of SAM-pointed domain-containing Ets-like factor (SPDEF) and its regulation of mucin production in CRSwNP ...
Wang Guihua G Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, - - 2014
PIK3R3, an isoform of class IA phosphoinositide 3-kinase (PI3K), specifically interacts with cell proliferation regulators, such as retinoblastoma and proliferation cell nuclear antigen, to promote cell proliferation. However, the mechanisms behind the upstream signaling pathway of PIK3R3 remain unclear to date. This study showed that PIK3R3 expression was regulated by ...
Tae Chung Hyun - - 2014
Although altered levels of adiponectin have been reported as a potential risk factor in colorectal cancer (CRC), the importance of the role played by adiponectin in colorectal carcinogenesis has not been established. We sought to examine the expression pattern of adiponectin and adiponectin receptors (AdipoRs) in the normal-adenoma-carcinoma sequence and ...
Ahmed Hanaa H HH Hormones Department, Medical Research Division, National Research Centre, 12411, Dokki, Giza, Egypt, - - 2014
This study was designed to investigate the role of curcumin against hepatocellular carcinoma (HCC) induced in rats. Forty rats were divided into five groups. Group (1) was negative control. Groups (2), (4), and (5) were orally administrated N-nitrosodiethylamine for HCC induction, then group (2) was left untreated, and group (4) ...
Xu Hua H University of Arizona Health Sciences - - 2014
Sodium/hydrogen exchanger (NHE) 8 is expressed at the apical membrane of the epithelial cells and plays important roles in neutral sodium absorption in the gastrointestinal tract and the kidney. It also has an important role in epithelial mucosal protection in the gastric gland and the intestine. Although NHE8 has broad ...
Zhu Yi - - 2014
BackgroundMUC4 plays important roles in the malignant progression of human pancreatic cancer. But the huge length of MUC4 gene fragment restricts its functional and mechanism research. As one of its splice variants, MUC4/Y with coding sequence is most similar to that of the full-length MUC4 (FL-MUC4), together with alternative splicing ...
Mori Yugo Y Kyoto Sangyo University, - - 2014
Mucin 1 (MUC1) is overexpressed in various human malignant tumors and its expression is correlated with a poor prognosis. MUC1 engages in signal transduction by interacting with receptors for growth and differentiation factors, which contributes to the growth and survival of cancer cells. However, the mechanism by which MUC1 promotes ...
Vasuri Francesco F Department of Experimental, Diagnostic and Specialty Medicine (DIMES), S.Orsola-Malpighi Hospital, Bologna University, Bologna, - - 2014
To investigate the immunohistochemical expression of Dyskerin, a biomarker involved in ribosome production and telomeres maintenance, in human fetal, adult and neoplastic bile ducts, as well as the possible correlations with cholangiocarcinoma aggressiveness. Sixty consecutive intrahepatic cholangiocarcinomas were collected and used for a tissue micro-array construction (total 176 cores); clinical ...
Alam Maroof M Dana-Farber Cancer Institute, Harvard Medical - - 2014
The LIN28B→let-7 pathway contributes to regulation of the epithelial-mesenchymal transition (EMT) and stem cell self-renewal. The oncogenic MUC1-C transmembrane protein is aberrantly overexpressed in lung and other carcinomas; however, there is no known association between MUC1-C and the LIN28B→let-7 pathway. Here in non-small cell lung cancer (NSCLC), silencing MUC1-C downregulates ...
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