Search Results
Results 1 - 50 of 1660
1 2 3 4 5 6 7 8 9 10 >
Buell-Gutbrod Rebecca R Departments of Pathology (R.B.-G., A.C., A.M., K.G.) Gynecologic Oncology (N.L.), University of Chicago, Chicago, Illinois Department of Pathology (K.G.), UT Southwestern Medical Center, Dallas, - - 2015
Progesterone inhibits the proliferative growth effects of estrogen in the endometrium and prevents the development of endometrial hyperplasia and Type I adenocarcinoma. The exact mechanism of this action is unknown. The progesterone-induced helix-loop-helix transcription factor Heart and Neural Crest Derivatives Expressed 2 (Hand2) was recently shown to suppress production of ...
Lee Hsiang-Ying HY Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, - - 2014
Urothelial carcinoma (UC) originating from the bladder (UBUC) and upper urinary tract (UTUC) is the most common type of urinary tract tumor. While its pathogenesis remains obscured. Computerizing a published transcriptomic database of UBUC (GSE31684), we identified Inhibin, Beta A (INHBA) as the most significant upregulated gene associated with tumor ...
Kanda Mitsuro M Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan, - - 2014
Genetic signatures may differ by histopathologic and anatomic subtypes of gastric cancer (GC). B-cell translocation gene 1 (BTG1) was identified as one of genes downregulated in GC tissues from our microarray data. To evaluate the clinical implications of BTG1 expression in GC and the genetic diversity among GC subtypes. BTG1 ...
Reza Abu M M T AM Laboratory of Stem Cell and Regenerative Biotechnology, Department of Animal biotechnology, College of Animal life sciences, Kangwon National - - 2014
Mesenchymal-epithelial transition (MET) is an inevitable process for cellular reprogramming. MET could be induced by suppressing epithelial-mesenchymal transition (EMT) signaling and activating an epithelial program within the cells. Aiming at MET, we investigated the potential of keratinocyte growth factor (KGF) and bone morphogenetic protein (BMP)-6 separately for the induction of ...
Yang Y Y Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, - - 2014
Preliminary studies showed that miR-21 is overexpressed in some human cancers. However, the role of miR-21 in cancer is still unclear and even controversial. Our purpose was to investigate the biological effects of miR-21 on A549 non-small cell lung cancer (NSCLC) cells and the underlying mechanisms of those effects. The ...
Huang Xin-Ping XP Research department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, - - 2014
Deregulated microRNAs (miRNAs) and their roles in carcinogenesis and cancer progression have attracted much attention. In previous studies conducted in our laboratory, the Illumina Solexa massively parallel signature sequencing (MPSS) of miRNomes in nontumor and hepatocellular carcinoma (HCC) tissues revealed that miR-486-5p was significantly downregulated in HCC, but its role ...
Pyo Jung-Soo JS Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 78 Saemunan-gil, Jongno-gu, Seoul, 110-746, South - - 2014
Bile acids might induce mucin expression and regulate tumor behavior in esophageal and colon cancers. However, little is known about the effect of bile acids on tumor invasiveness of gastric carcinoma (GC). The aim of the current study was to elucidate the mechanisms by which bile acids regulate tumor invasion ...
Pekow Joel J University of Chicago - - 2014
The colon differs regionally in local luminal environment, excretory function, and gene expression. Polycistronic miR-143 and miR-145 are down-regulated early in colon cancer. We asked if these miRNA might be differentially expressed in the proximal versus the distal colon, contributing to regional differences in protein expression. Primary transcripts and mature ...
Duan Meng M Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of - - 2014
Triggering receptors expressed on myeloid cells 1 (TREM-1) is a novel molecule that modulates inflammatory responses. Hepatocellular carcinoma (HCC) is a well-known type of inflammation-related cancer. However, TREM-1 expression and its direct effects on HCC cells have not been previously determined. Western blotting, quantitative reverse transcription-PCR (qRT-PCR), and immunofluorescence were ...
Agrawal Vishal V Department of Pediatrics, University of California, San - - 2014
BACKGROUNDAt birth, the large fetal adrenal involutes rapidly and the patterns of steroidogenesis change dramatically; the event(s) triggering these changes remain largely unexplored. Fetal abdominal viscera receive hypoxic blood having a partial pressure of oxygen of only ~2 kPa (20-23 mmHg); perinatal circulatory changes change this to adult values (~20 ...
Bacigalupo María L ML Institute of Biological Chemistry and Biophysics "Prof. Alejandro C. Paladini" (UBA-CONICET), Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, C1113AAD, Buenos Aires, - - 2014
Galectin-1 (Gal1), a β-galactoside-binding protein abundantly expressed in tumor microenvironments, is associated with the development of metastasis in hepatocellular carcinomas (HCC). However, the precise roles of Gal1 in HCC cell invasiveness and dissemination are uncertain. Here, we investigated whether Gal1 mediate epithelial-mesenchymal transition (EMT) in HCC cells, a key process ...
Li Bin-Kui - - 2014
BackgroundMicroRNA-106b (miR-106b) is a member of the miR-106b¿~¿25 cluster. It has been reported that miR-106b acts as an oncogene and is upregulated in many human cancers. However, the prognostic value of miR-106b in hepatocellular carcinoma (HCC) remains unclear. The aim of this study was to investigate the clinical significance of ...
Khammanivong Ali - - 2014
Bone morphogenetic protein (BMP) signaling is thought to play key roles in regulating the survival and maintenance of cancer stem cells (CSCs), which contribute to disease recurrences and treatment failures in many malignances, including head and neck squamous cell carcinoma (HNSCC). Intracellular BMP signaling is regulated by SMAD specific E3 ...
Ranieri Danilo D Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Medicina Clinica e Molecolare, Sapienza Università di Roma, - - 2014
The E5 oncoprotein of the human papillomavirus type 16 (HPV16 E5) deregulates epithelial homeostasis through the modulation of receptor tyrosine kinases and their signaling. Accordingly, the fibroblast growth factor receptor 2b (FGFR2b/KGFR), epithelial splicing transcript variant of the FGFR2, is down-modulated by the viral protein expression, leading to impairment of ...
Ozawa Daigo D Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan, - - 2014
Esophageal squamous cell carcinoma (ESCC) is an important cause of cancer-related death worldwide. To improve prognoses in patients with ESCC, we evaluated the potential of transforming growth factor-beta-induced protein (TGFBI), which is overexpressed in ESCC, as a therapeutic candidate. We examined the clinical significance of TBFBI in 102 ESCC samples ...
Sun Dongmei D Key Laboratory of Molecular Epigenetics of Ministry of Education of China, Northeast Normal University, Renmin Street 5268, Changchun, 130024, Jilin, - - 2014
L-Sox5 is a member of sex-determining region Y-type high mobility group box (SOX) family of transcription factors. We assessed the effects of retroviral overexpression of L-Sox5 on chondrocyte differentiation using the clonal murine cell line ATDC5. We observed a temporal-restricted expression pattern of L-Sox5 in insulin-induced ATDC5 cells differentiating toward ...
Pan Linjiang - - 2014
BackgroundAberrant expression of microRNA-148a (miR-148a) has been reported in several types of malignancies. However, its expression and clinicopathological significance in hepatocellular carcinoma (HCC) has not been entirely clarified. Our objective was to investigate the clinicopathological contribution of the miR-148a expression in HCC formalin-fixed paraffin-embedded (FFPE) tissues.MethodsEighty-nine HCC and their para-cancerous ...
Wang Linlin L Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. - - 2014
The development of strategies for the inhibition of non‑small cell lung cancer (NSCLC) progression and metastasis have been mainly unsuccessful, in part due to insufficient mechanistic understanding of the disease. In the current study, the critical role of the co‑expression of immunoglobulin‑like transcript 4 (ILT4) and its ligands, angiopoietin‑like proteins (ANGPTLs), ...
Li Wenping W From the Departments of Pathology - - 2014
Uroplakin (UP) II and UPIII are highly specific immunohistochemical markers for urothelial differentiation. Here we studied the sensitivity of UPII and UPIII in conventional and variant urothelial carcinomas (UCs). Immunohistochemical staining for UPII and UPIII was performed on tissue microarray slides, including 105 conventional bladder UCs (BUCs), 90 upper urinary ...
Lim Whasun W Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of - - 2014
Prostaglandin D2 synthase (PTGDS), also known as a glutathione-independent prostaglandin D synthase, catalyzes prostaglandin H2 to prostaglandin D2 that exhibits functions that include regulation of the central nervous system, contraction/relaxation of smooth muscle and inhibition of platelet aggregation. Gene profiling data based on our previous study indicated that PTGDS is ...
Kan Heping H Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Road North, Guangzhou 510515, China. Electronic address: - - 2014
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Aberrant expression of miRNAs contributes to HCC development. Here, we observed elevated miR-520g expression in tumor samples from HCC patients with relapse and metastasis, and this high miR-520g expression was correlated with poor survival. Through gain- and loss-of-function ...
Maayah Zaid H ZH Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, - - 2014
RL-14 cells, human fetal ventricular cardiomyocytes, are a commercially available cell line that has been established from non-proliferating primary cultures derived from human fetal heart tissue. However, the expression of different drug metabolizing enzymes (DMEs) in RL-14 cells has not been elucidated yet. Therefore, the main objectives of the current ...
Zhou Yi - - 2014
OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1) is a deubiquitinating enzyme (DUB) that belongs to the OTU (ovarian tumor) superfamily. The aim of this study was to clarify the role of OTUB1 in colorectal cancer (CRC) and to identify the mechanism underlying its function. Two hundred and sixty CRC samples ...
Wang Xiaoxiong X Pharmacy College, Jinan University, Guangzhou 510632, - - 2014
Trichostatin A (TSA) is a kind of classical histone deacetylase (HDAC) inhibitor. In this study, we reported the reversal effects of TSA on EMT and investigated the possible involved molecular mechanisms in SW480 and PC3 cells. Firstly, we observed that TSA induced the reversal process of epithelial-mesenchymal transition (EMT) in ...
Bozdogan Onder O Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey; Department of Pathology, Medical Faculty, Kırıkkale University, Kırıkkale, - - 2014
Basal cell carcinomas (BCCs) are common malignant skin tumors. Despite having a significant invasion capacity, they metastasize only rarely. Our aim in this study was to detect the expression patterns of the NM23-H1, NDRG1, E-cadherin, RHOGDI2, CD82/KAI1, MKK4, and AKAP12 metastasis suppressor proteins in BCCs. A total of 96 BCC ...
Yang Peng P Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, 1838#, North of Guangzhou Avenue, Guangzhou, 510515, Guangdong, People's Republic of - - 2015
Human sacral chondrosarcoma, the most common one of malignant tumors, has a potent capacity to invade locally and metastasize. Notably, CXCR4 and survivin are widely recommended as a candidate of the molecule-targeted therapy. However, the roles and associations of CXCR4 and survivin in sacral chondrosarcoma have not been well characterized. ...
Xia Suhua S Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of - - 2015
Pancreatic ductal adenocarcinoma (PDAC) is one of the most leading causes of cancer-related death. Cancer stem cell is responsible for tumor initiation, metastasis and relapse. Sox9 is a pancreatic stem cell marker. PI3K/PTEN/Akt/mTORC is an important signal for maintaining stem cells. The purpose of this study is to determine the ...
Wang Qingqing Q Department of General Surgery, Nantong University Affiliated Hospital, Nantong, 226001, Jiangsu, - - 2015
RAB27A is a member of Rab family GTPases involved in cellular vesicle trafficking, and TP53 has recently been implicated in regulating the exosome secretion pathway. Because exosome secretion plays an important role in modulating tumor microenvironment and invasive growth, we hypothesized that RAB27A and TP53 expression might be associated with ...
Stewart Colin Jr CJ Department of Histopathology, King Edward Memorial Hospital, Perth, Western Australia; School for Women's and Infants' Health, University of Western - - 2014
The significance and pathogenesis of irregular or asynchronous maturation within endometrial glands remains uncertain. This study investigated differences in epithelial hormone receptor immunoreactivity and stromal cell calretinin, CD34 and p16 expression in morphologically normal secretory endometrium and in asynchronous (non-secretory) endometrial glands (AEGs). Nineteen consecutive endometrial specimens demonstrating AEGs were ...
Li G-L GL Fisheries College, Guangdong Ocean University, Zhanjiang, 524088, China; Key Laboratory of Aquaculture in South China Sea for Aquatic Economic Animal of Guangdong Higher Education Institutes, Guangdong Ocean University, Zhanjiang, 524088, - - 2014
In this study, the complete foxl2 complementary (c)DNA sequence was isolated by simple modular-architecture research tool (SMART)er rapid amplification of cDNA ends (RACE). Two year-old female spotted scat, Scatophagus argus, were reared at different temperatures (23, 26 and 29° C) for 6 weeks, or fed with different concentrations of dietary ...
Dunn Lorna J LJ Northern Oesophago-Gastric Cancer Unit, Royal Victoria Infirmary, Queen Victoria Road, Newcastle-upon-Tyne, NE1 4LP, UK, - - 2014
Trefoil proteins are believed to have an important role in mucosal protection and repair in the gastrointestinal tract. They are well recognized in Barrett's esophagus and considered a potential biomarker for the condition. Metaplasia occurring in the esophageal remnant after esophagectomy is a human model for the early stages of ...
Figueira Ana - - 2014
BackgroundCadherins are calcium-dependent cell-to-cell adhesion glycoproteins playing a critical role in the formation and maintenance of normal tissue architecture. In normal mammary gland, E-cadherin is expressed by luminal epithelial cells, while P-cadherin is restricted to myoepithelial cells. Changes in the expression of classical E- and P-cadherins have been observed in ...
Tsang Felice Ho-Ching FH State Key Laboratory for Liver Research and Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, - - 2014
Hepatocellular carcinoma (HCC) is one of the most common human cancers. Recently, emerging evidence has suggested the role of long non-coding RNAs (lncRNAs) in human carcinogenesis. In this study we aimed to investigate the expression and functional implications of lncRNAs in human HCC. 88 well-annotated lncRNAs were profiled in primary ...
Zhang Shulin - - 2014
BackgroundThe Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in several types of cancer including mesothelioma. Protein kinase CK2 affects several cell signaling pathways through the mechanism of phosphorylation.MethodsProtein and mRNA levels of CK2¿ and Gli1 were tested by quantitative RT-PCR and ...
Lin Li - - 2014
Hepatocyte nuclear factor-3beta (HNF-3beta) plays a critical role in hepatocyte differentiation and controls liver-specific gene expression during the development of hepatocellular carcinoma (HCC), but the molecular basis of this process has not been fully elucidated. microRNAs (miRNAs) are powerful, post-transcriptional regulators of gene expression. Whether miRNAs can impact the effects ...
Feng Ming-Xiang MX 1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China - - 2014
Objective: To explore the expression of cyclophilin A (CypA) in esophageal tissues and its clinical significance. Method: Expression of CypA was detected in 236 esophageal cancer tissues and 236 normal tissues by using an immunohistochemical method, and the relationship between CypA expression and clinical outcomes was observed. Results: There were ...
Lei Mingzhu M College of Veterinary Medicine of Northwest A&F University, Yangling, Shaanxi, - - 2014
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) interactions affect the regulation of cytotoxic/immunotrophic pathways that are themselves under control of IL-18. The effect of Fn14 on regulation of endometrium IL-18 expression, however, remains unclear. The aim was to determine the mode of ovarian steroid action ...
Kamphues Carsten C From the *Department of General, Visceral and Transplantation Surgery, and †Institute of Pathology, Charité University Hospital, Berlin; ‡Institute of Pathology, University Hospital Heidelberg; and §National Center for Tumor Diseases, Heidelberg, - - 2014
Recently, aberrations in the gene encoding for ataxia-telangiectasia-mutated (ATM) protein kinase have been reported for pancreatic ductal adenocarcinomas (PDAC). These findings argue that ATM deficiency may play a role during carcinogenesis. Therefore, in this study, we investigated the clinical relevance of ATM expression and ATM activation in PDAC. Both ATM ...
Yuan Taize T Department of Radiotherapy, Affiliated Cancer Hospital of Guangzhou Medical University, No. 78, Hengzhigang Road, Yuexiu District, Guangzhou, 510095, Guangdong, - - 2014
Metastasis-associated protein 1 (MTA1) is related to tumour metastasis and poor prognosis in various human cancers. The aim of this study was to investigate the expression of MTA1 in nasopharyngeal carcinoma (NPC) and explore the prognostic value of MTA1 in NPC patients. The expression of MTA1 in 136 human NPC ...
Wang Zhaojing Z Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, - - 2014
Over-expression of ATP-binding cassette (ABC) transporters, a large family of integral membrane proteins that decrease cellular drug uptake and accumulation by active extrusion, is one of the major causes of cancer multi-drug resistance (MDR) that frequently leads to failure of chemotherapy. Carbon nanotubes (CNTs)-based drug delivery devices hold great promise ...
Boscia Francesca F Dipartimento di Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, Università di Napoli "Federico II, 80131, Naples, - - 2014
The G protein-coupled estrogen receptor (GPR30) is suggested to be involved in non-nuclear estrogen signalling and is expressed in a variety of hormone dependent cancer entities. It is well established that oestrogens are involved in pathological germ cell proliferation including testicular germ cell tumours. This study was performed to further ...
Hamamoto Junko J Department of Pulmonary Medicine, School of Medicine, Keio - - 2014
We identified TMPRSS4 (transmembrane protease, serine 4) as a putative, druggable target by screening surgically resected samples from 90 Japanese non-small lung cancer (NSCLC) patients using cDNA microarray. TMPRSS4 has two druggable domains and up-regulated in 94.5% of the lung cancer patient specimens. Interestingly, we found that TMPRSS4 expression was ...
Li Hai-Feng HF Department of Pathology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P.R. - - 2014
The aim of the present study was to investigate the expression and function of metastasis-associated in colon cancer 1 (MACC1) in tongue squamous cell carcinoma (TSCC) and its relationship with the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147). Levels of MACC1 and EMMPRIN expression were analyzed in 65 paraffin‑embedded ...
Li Chunyan C Department of Oncology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. - - 2014
v-ets erythroblastosis virus E26 oncogene homolog 1 (ETS-1) plays crucial roles in a spectrum of malignancies. ETS-1 has gained attention in cancer research for its importance in cell migration, invasion and proliferation. In the present study, we focused on the effect of ETS-1 on epithelial-mesenchymal transition (EMT), which is characterized by ...
He Bin B Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. - - 2014
The increasing expression of microRNA‑155 (miR‑155) and decreasing expression of RNA‑binding protein quaking (QKI) in colon cells have been observed previously. In this study, we attempted to establish the correlation between miR‑155 and QKI. In addition, we assessed whether the expression of miR‑155 and QKI is linked to the proliferation ...
Xue Jing J Department of Epidemiology, Public Health School of Central South University, Changsha, 410078, China, - - 2014
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. P21-activated kinase 4 (PAK4) has been identified as an oncogenic protein in a variety of cancers. However, the contribution and regulation of PAK4 in HCC remain poorly understood. In the present study, we found that inhibition of PAK4 expression ...
Sperandio Felipe F FF Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, 37130-000, MG, Brazil; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA. sperandio@usp.br, - - 2014
Low-level laser therapy (LLLT) has been extensively employed to improve epithelial wound healing, though the exact response of epithelium maturation and stratification after LLLT is unknown. Thus, this study aimed to assess the in vitro growth and differentiation of keratinocytes (KCs) and in vivo wound healing response when treated with ...
Hwang David H DH Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, - - 2014
Myc family members are important contributors to oncogenesis in a variety of tumors. Identification of therapeutic targets are needed in small cell lung carcinoma (SCLC), an aggressive disease with limited treatment options. Sequencing studies have identified MYC amplification in 2-7% of SCLC. We hypothesized that immunohistochemistry (IHC) will detect Myc ...
Dong Liangpeng L Department of General Surgery, the First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, 453100, - - 2014
More and more evidence has demonstrated that astrocyte elevated gene-1 (AEG-1) is tightly associated with progression, metastasis, and unfavorable prognosis in many malignancies. However, the potential biological role of AEG-1 in gastric carcinoma (GC) has not been thoroughly delineated. In the current study, we found that AEG-1 mRNA and protein ...
Xuan Xaioyan X Department of Pathology, The First Affiliated Hospital and Key Laboratory of Tumor Pathology, Zhengzhou University School of Medicine, Zhengzhou, Henan, - - 2014
Stat3 alters the expression of its downstream genes and is associated with tumor invasion and metastasis in several human cancers. Its role in esophageal squamous cell carcinoma (ESCC) has not been well characterized. We examined the tumor sections of 100 cases of ESCC by immunohistochemistry and observed significant overexpression of ...
1 2 3 4 5 6 7 8 9 10 >