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Wang Yumin Y Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of - - 2014
Studies showed that long chain non-coding RNAs (lncRNAs) involved in the development and progression of lung cancer. However, the mechanisms of EGFR exon 19 deletion in lung adenocarcinoma were unclear. Lung adenocarcinoma was divided into EGFR exon 19 deletion group and EGFR wild-type group. We studied the differential expression profiles ...
Nigam Jaya J Department of Surgical Gastroenterology, King George's Medical University, Lucknow, 226003, Uttar Pradesh, - - 2014
The role of survivin in gallbladder cancer (GBC) has not been evaluated. We investigated survivin protein expression in serum of patients with gallbladder diseases (cholelithiasis, n = 30; GBC, n = 39) and compared with healthy controls (n = 25). Clinicopathological parameters, diagnosis and prognosis of patients with GBC were correlated with the expression of serum ...
Kunej Tanja T Department of Animal Science, Biotechnical Faculty, University of Ljubljana , Domzale , Slovenia - - 2014
Abstract Long non-coding RNAs (lncRNAs) are transcripts without protein-coding capacity; initially regarded as "transcriptional noise", lately they have emerged as essential factors in both cell biology and mechanisms of disease. In this article, we present basic knowledge of lncRNA molecular mechanisms, associated physiological processes and cancer association, as well as ...
Urban Peter P Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovak - - 2014
Clinical diagnosis of gynaecological malignancies is usually successful in the advanced stages of the tumour, and this has a major impact on the success of therapy. Therefore, in the last few years, cancer research has tried to identify and characterise new biochemical and molecular markers needed as predictive indicators for ...
Lewis Annabelle A Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, - - 2014
A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 polymorphism, rs16969681, is also associated with CRC susceptibility, conferring ∼20% differential ...
Kashihara Hideya H Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan, - - 2014
Protein kinase Cι (PKCι) is an important oncogenic K-ras effector, and its expression is correlated with tumor angiogenesis. The role of PKCι in gastric cancer remains unclear. The aim of this study was to clarify the role of PKCι in gastric cancer. Twenty-eight patients with gastric cancer who underwent gastrectomy ...
Raghoebir Lalini L Department of Pediatric Surgery, Erasmus Medical Centre, Rotterdam, The - - 2014
Colorectal cancer (CRC) can be divided into non-mucinous and mucinous subtypes, of which the latter portends to have a worse clinical prognosis. A previous study suggested a putative link between SOX2 expression observed selectively in mucinous CRC and the induction of the gastric mucin MUC5AC. In this study, we re-evaluated ...
Kimura Tomoko T Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, - - 2014
Mitochondrial transcription factor A (mtTFA) plays a crucial role in both the transcription and maintenance of mitochondrial DNA. A high expression of mtTFA has been demonstrated in several solid tumors, and is closely associated with cancer cell survival/apoptosis and growth. However, its expression pattern in pancreatic ductal adenocarcinoma (PAC) remains ...
Han Lei L Department of Hepatobiliary and Pancreas Surgery, The General Hospital of Shenyang Military Region, Shenyang, Liaoning 110016, P.R. - - 2014
Pancreatic adenocarcinoma (PA) is a leading cause of adult cancer mortality, and surgery is still the best available treatment strategy. However, PA can recur at any time and has limited prognosis. It is therefore necessary to explore novel serum biomarkers of PA to allow the early diagnosis of PA. Soluble ...
Singh Lata L Department of Ocular Pathology, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, - - 2014
Regulation of apoptosis is a complex process which involves a number of genes including bcl-2, bcl-x, bax and other bcl-2 family members. The aim of the present study is to assess the expression of Bcl- 2 and Bax in retinoblastoma (Rb) and correlate them with clinical & histopathological parameters. The ...
Essandoh Kobina K Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH - - 2014
Sepsis is the major cause of death in the intensive care unit (ICU). Numerous biomarkers have been studied to identify the cause and severity of sepsis but these factors cannot differentiate between infectious and non-infectious inflammatory response. MicroRNAs (miRNAs) are non-coding RNA transcripts that regulate the expression of genes by ...
Zhang Wu W Department of Adiotherapy, The Third Affiliated Hospital, Wenzhou Medical College, Wenzhou, - - 2014
We tried to investigate the expression characteristics of KAI1, a suppressor of wide-spectrum tumor metastasis, and vascular endothelial growth factor (VEGF), the most common angiogenesis factor, and then to analyze their diagnostic value for hepatocellular carcinoma (HCC). The protein and mRNA expression levels of KAI1 or VEGF in HCC tissues ...
Yuan Ray-Hwang RH Department of Surgery, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 10051, Taiwan, Republic of - - 2014
Hepatocellular carcinoma (HCC) frequently exhibits biliary differentiation, which is typically overlooked. Hepatocyte nuclear factor 1β (HNF1β), a bile duct-specific transcription factor expressed in bile ducts but not in the normal hepatocytes, is also expressed in HCC. The expression of HNF1β and the biliary differentiation marker cytokeratin 19 (CK19) were retrospectively ...
Beca Francisco F http://orcid.org/0000-0002-4409-012X Department of Medical Oncology, Dana-Farber Cancer Institute/Harvard Medical School, Boston, Massachusetts, USA IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal Faculty of Medicine, Department of Pathology and Oncology, University of Porto, Porto, - - 2014
Despite considerable interest in the PI3K/AKT/mTOR pathway in breast carcinomas (BC), published data reports contradictory results regarding the association of phosphorylated mammalian target of Rapamycin (p-mTOR) expression with clinico-pathological features and prognosis in BC. Here, we evaluate the main clinico-pathological associations with p-mTOR expression in BC, with focus on the ...
Kitahashi Tsukasa T From the Central Animal Division, National Cancer Center Research Institute, Tokyo, - - 2014
The aim of the present study was to characterize molecular targets for the prevention/diagnosis of pancreatic cancer using a chemically induced hamster pancreatic carcinogenesis model, in which background injuries to the parenchyma, for example, chronic pancreatitis or acinar atrophy, are limited. Gene expression profiles in atypical hyperplasias were first investigated ...
Ruggieri Simona S Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, - - 2014
Bcl-6 translocation is a genetic alteration that is commonly detected in Primary Central Nervous System Lymphoma. The role of this protein in cerebral tumors is unclear. In this study we investigated Bcl-6 translocation and its transcriptional and translational levels in formalin-fixed, paraffin-embedded cerebral tissue sections from Glioblastoma (GBM), low-grade glioma ...
Dasgupta Subhamoy S S Dasgupta, Molecular and Cellular Biology, Baylor College of Medicine, Houston, United - - 2014
Transcriptional coactivators have evolved as an important new class of functional proteins that participate with virtually all transcription factors and NRs to intricately regulate gene expression in response to a wide variety of environmental cues. Recent findings have highlighted that coactivators are important for almost all biological functions, and consequently, ...
Song Ruipeng R Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, - - 2014
Hepatocellular carcinoma (HCC) is a highly vascularized tumor with frequent extrahepatic metastasis. Active angiogenesis and metastasis are responsible for rapid recurrence and poor survival of HCC. However, the mechanisms that contribute to tumor metastasis remain unclear. Here, we evaluate the effects of ATPase inhibitory factor 1 (IF1), an inhibitor of ...
Morishita Asahiro A Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761-0793, - - 2014
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Despite improvementsin HCC therapy, the prognosis for HCC patients remains poor due to a high incidence of recurrence.An improved understanding of the pathogenesis of HCC development would facilitate the development of moreeffective outcomes for the diagnosis and treatment ...
Ikemoto Tetsuya T Department of Surgery, Institute of Health Biosciences, the University of Tokushima, Kuramoto 3-18-15, Tokushima 770-8503, - - 2014
This study was performed to elucidate the expression of the Notch signaling pathway and its correlations to clinicopathological factors of intraductal papillary mucinous neoplasms (IPMNs).It is incontrovertible that regulatory T cells (Tregs) play an important role in tumor immunity. However, the whole mechanism of control of peripheral Tregs remains unclear. ...
Liu Sheng S aDepartment of Gastrointestinal Surgery, Xiangya Hospital of Central South University bDepartment of Pathology, Hunan Provincial Cancer Hospital, Changsha, - - 2014
Snail, a zinc finger structure transcription inhibitory factor, has been reported to play an important role in the metastatic progression of several types of cancer. The aim of the study was to identify potential biomarkers for metastasis in gastrointestinal stromal tumors (GISTs) by examining the expression levels of Snail, E-cadherin, ...
Miyata Yasuyoshi Y Department of Nephro-Urology, Nagasaki University Graduate School of Biomedical, Sciences, Nagasaki, Japan. Electronic address: - - 2014
Heme oxygenase (HO)-1 is upregulated in malignancies and, in turn, regulates other cancer-related factors. Although HO-1 expression has been associated with cigarette smoking under various pathologic conditions, little is known about their association in patients with bladder cancer. HO-1 expression was assessed in 215 formalin-fixed bladder cancer specimens by immunohistochemistry. Microvessel ...
Shen Yanyun Y Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. - - 2014
Cyclin D1 is a member of the G1 cyclin family that regulates the transition through the G1 phase of the cell cycle and is involved in the neoplastic transformation of certain tumors. This study was designed to investigate the expression of cyclin D1 in Bowen's disease (BD) and cutaneous squamous ...
Zhai Jianwen J Department of Cardiothoracic Surgery, The Affiliated Hospital of Hebei University of Engineering, Handan, Hebei 056002, P.R. - - 2014
It has been shown that death-associated protein kinase (DAPK) family and E-cadherin play significant roles in the promotion of apoptosis and the suppression of cell adhesion and migration, and are involved in tumor metastasis. Ezrin, a cytoplasmic peripheral membrane protein, has been shown to interact with E-cadherin to participate in ...
Xu Xiao-Yan XY Department of Pathology, People's Hospital of Zhengzhou Attached to Southern Medical University, Zhengzhou, PR - - 2014
This study aimed at evaluating the utility of a panel of antibodies, consisting of cytokeratins (CK) 5/6, CK34βE12, p63, thyroid transcription factor-1 (TTF-1), and CK7 for distinguishing between squamous cell carcinoma (SCC) and adenocarcinomas (Ad), as well as their expression with clinicopathological parameters and prognosis in SCC and Ad. 111 ...
Li Cong C Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Dong'an road, 270, Shanghai, 200032, - - 2014
Chemoradiotherapy has been commonly used as neoadjuvant therapy for rectal cancer to allow for less aggressive surgical approaches and to improve quality of life. In cancer, it has been reported that CXCL10 has an anti-tumor function. However, the association between CXCL10 and chemoradiosensitivity has not been fully investigated. We performed ...
Mariaselvam Christina Mary CM Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India; INSERM, UMRS 1160, Saint Louis Hospital, Paris F75010, - - 2014
Rheumatoid arthritis (RA), a chronic inflammatory disease affects up to 1% of the general population. Early diagnosis and treatment are limited by the absence of specific and reliable diagnostic/prognostic biomarkers. This study was carried out in 48 Tamil South Indian RA patients and 49 healthy controls (HC) to identify any ...
Stella Flavia F Laboratorio de Genética de Neoplasias Linfoides, Instituto de Medicina Experimental, CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina. Electronic address: - - 2014
In this study, we have examined CKS1B gene expression and copy number in a total of 114- patients at diagnosis: 83 with multiple myeloma (MM) and 31 with monoclonal gammopathy of undetermined significance (MGUS). Results were correlated with cytogenetics, FISH and clinical characteristic. Significant CKS1B mRNA levels in MM compared ...
Douds Jonathan J JJ Departments of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, - - 2014
Previous studies showed that CD200 expression is a prognostic factor for plasma cell myeloma (PCM), but the prognostic effect is conflicting between studies. We studied CD200 protein expression and the stability of expression in PCM to clarify its potential utility in diagnosis, prognosis and monitoring of disease. CD200 expression was ...
Smith Steven Christopher SC 1] Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA [2] Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, - - 2014
Recent molecular advances have identified a novel, clinically aggressive subgroup of undifferentiated round cell sarcomas defined molecularly by oncogenic fusion of the gene, CIC, and either DUX4 or its paralog, DUX4L, herein termed CIC-DUX sarcomas. Morphologically, CIC-DUX sarcomas are round cell sarcomas with high-grade nuclear features, including vesicular chromatin and ...
Nigam Jaya J Department of Surgical Gastroenterology, King George's Medical University, Lucknow, Uttar Pradesh, 226003, - - 2014
Survivin, an inhibitor of apoptosis, has been shown to be expressed in various malignancies. However, its role in gallbladder cancer (GBC) has not been evaluated yet. We investigated its expression in peripheral blood of patients with gallbladder diseases (gallstone disease (GSD), n = 30; GBC, n = 39) and compared with healthy controls (n = 25). ...
Adam Patrick P Institute of Pathology, Ingolstadt, - - 2014
Due to its profound therapeutic consequences, the distinction between thymoma and T-lymphoblastic lymphoma in needle biopsies is one of the most challenging in mediastinal pathology. One essential diagnostic criterion favouring thymoma is the demonstration of increased numbers of keratin-positive epithelial cells by immunohistochemistry. Loss of keratin expression in neoplastic epithelial ...
Sui Lu L Department of Pathophysiology, Shenyang Medical College, Huanghe North Avenue No.146, Shenyang, 110034, People's Republic of China, - - 2014
We carried out the current meta-analysis of relevant cohort studies in an attempt to investigate the relationships between vascular endothelial growth factor (VEGF) expression and pathological characteristics of diffuse large B cell lymphoma (DLBCL). The following electronic databases were searched for relevant articles without any language restrictions: Web of Science ...
Tao Tao T Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, - - 2014
Recent studies have shown that many molecular mechanisms, such as the EGFR, AKT, STAT3, and beta-catenin pathways, are involved in glioma. However, the prognosis of the disease remains poor. Explorations of the underlying mechanisms of glioma and identification of effective markers for early diagnosis and accurate prognostication remain important today. ...
Ishikawa Daichi D The Department of Surgery, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima 770-8503, - - 2014
Intraductal papillary mucinous neoplasm (IPMN) is a well-established entity among pancreatic neoplasms, which ranges from low-grade dysplasia to invasive carcinoma. Epithelial-mesenchymal transition (EMT) contributes to tumor progression in various cancers. Moreover, Notch signaling is one of the important upstream effectors of EMT promotion. Currently, it is unclear whether EMT causes ...
Karli Philemon P Division of Neurological Sciences, Department of Clinical Veterinary Neurology, Vetsuisse Faculty, University of Bern, Switzerland. Electronic address: - - 2014
In canine intervertebral disc (IVD) disease, a useful animal model, only little is known about the inflammatory response in the epidural space. To determine mRNA expression of selected cytokines, chemokines and matrix metalloproteinases (MMP) qualitatively and semi-quantitatively over the course of the disease and to correlate results to neurological status ...
Gungorduk Kemal K Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, - - 2014
To analyze the expression patterns of extracellular signal-regulated kinase (ERK1/2) and phosphorylated (p)-AKT in the tissues of non-pathologic endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer using indirect immunohistochemistry, and also to investigate the effect of ERK1/2 and p-AKT expression patterns on prognosis in endometrioid adenocancer. Immunolocalization ...
Bhandaru Madhuri - - 2014
To date only a handful of drugs are available for the treatment of melanoma. Among them vemurafenib, a BrafV600E specific inhibitor, showed promising results in terms of response rate and increase in median survival time. However, its effectiveness is limited by development of resistance and the search for additional drugs ...
Righi Luisella L From the Departments of Oncology and - - 2014
Malignant pleural mesothelioma (MPM) is a highly aggressive disease for which new prognostic biomarkers need to be identified. Caveolin-1 (CAV1), the most important member of caveolae, has been described as deregulated in MPM at the genomic level, but detailed histologic information on its distribution and prognostic role is still lacking. ...
El-Menshawy Nadia N Mansoura University Faculty of Medicine, Department of Clinical Pathology, Mansoura, - - 2014
Aberrant activation of transcription factor genes is the most frequent target of genetic alteration in lymphoid malignancies. The lymphoblastic leukemia-derived sequence 1 (LYL1) gene, which encodes a basic helix-loop helix, was first identified with human T-cell acute leukemia. Recent studies suggest its involvement in myeloid malignancies. We aimed to study ...
Alexopoulou Dimitra K DK Department of Biochemistry & Molecular Biology, University of Athens, Panepistimiopolis, 15701, Athens, - - 2014
Dysregulated expression of several KLK family members has been observed in colorectal adenocarcinoma. In the present study, the prognostic value of KLK11 mRNA expression as a molecular tissue biomarker in colorectal adenocarcinoma was examined. Using quantitative real-time PCR, KLK11 mRNA expression was studied in 120 cancerous and 41 paired noncancerous ...
Kazeminezhad Behrang B Department of Pathology, Shahidbeheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. - - 2014
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein with vital function during human embryogenesis in terms of cellular growth and migration. Although it has minimum and undetectable expression in human adult tissues, it is highly expressed in various types of cancer. Few studies have recommend application ...
Huang Yuanshen Y Molecular Medicine Lab and Chieng Genomics Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada; Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, - - 2014
Mycosis fungoides (MF) often mimics the common chronic inflammatory skin diseases and is difficult to be diagnosed with certainty, partly because of the lack of well-characterized molecular markers. Previously, we discovered that TOX, a key T cell development regulator,was aberrantly over-expressed in early stage MF. In the current multi-center study ...
Zhuang Zhuo-Nan ZN Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, PR China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, 250012, Shandong, PR - - 2014
Background. Over-expression of integrin β6 plays an important role in a variety of malignant tumor invasion and metastasis. Methods. The expression levels of integrin β6, MMP-2 and MMP-9 were analyzed by immunohistochemistry with human follicular thyroid carcinomas. Then we investigated their correlation with clinical outcomes parameters, relationship and the survival ...
Kaira Kyoichi K Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma, Japan; Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma, - - 2014
ASCT2 is highly expressed in cancer cells. However, the clinicopathological significance of ASCT2 expression in pancreatic cancer remains unclear. The aim of this study was to investigate the clinical significance of ASCT2 expression in pancreatic cancer. Ninety-seven patients with surgically resected pancreatic ductal adenocarcinoma were evaluated. Tumor sections were stained ...
Choi Jung-Woo JW Department of Pathology, Korea University Ansan Hospital, Ansan, Republic of - - 2014
To investigate the prognostic significance of lactate/proton monocarboxylate transporters MCT1, MCT4, and their chaperone CD147 expressions in urothelial carcinoma of the bladder (UCB). We examined the expressions of MCT1, MCT4, and CD147 proteins in a total of 360 cases of UCB by immunohistochemistry. The immunohistochemical expressions were quantified using an ...
Wahid Fazli F Biotechnology Program, COMSATS Institute of Information Technology, Abbottabad, Pakistan. Electronic address: - - 2014
MicroRNA (miRNA) is a small non-coding regulatory RNA of 21-25 nucleotides (nts) in length. miRNA works as a post-transcriptional regulator of a specific mRNA by inducing degradation or translation repression resulting in gene silencing. A large number of miRNA have been reported and many more are yet to be discovered. ...
Hanfstein Benjamin B Universitatsmedizin - - 2014
The vast majority of chronic myeloid leukemia patients express a BCR-ABL1 fusion gene mRNA encoding a 210 kDa tyrosine kinase which promotes leukemic transformation. A possible differential impact of the corresponding BCR-ABL1 transcript variants e13a2 (b2a2) and e14a2 (b3a2) on disease phenotype and outcome is still conflicting. A total of ...
Zhou Zhongren Z Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642. Electronic address: - - 2014
Bile acid reflux into the esophagus is important in the development of esophageal adenocarcinoma (EAC). Recently, vitamin D receptor (VDR) was recognized as a bile acid receptor as well as a vitamin receptor. Expression of VDR is reported to influence the development of various types of cancer, such as those ...
Jiang Wenjie - - 2014
Abstract MicroRNAs (miRNAs) are small RNAs that regulate target gene expression. Using microarray-based miRNA expression profiling, we compared the miRNA expression in granulocytes from 4 acute myeloid leukemia patients and 4 healthy controls. Thirty-four miRNAs were found to be differentially expressed, including 20 miRNAs that were upregulated and 14 miRNAs ...
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