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Yuan Ray-Hwang RH Department of Surgery, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 10051, Taiwan, Republic of - - 2014
Hepatocellular carcinoma (HCC) frequently exhibits biliary differentiation, which is typically overlooked. Hepatocyte nuclear factor 1β (HNF1β), a bile duct-specific transcription factor expressed in bile ducts but not in the normal hepatocytes, is also expressed in HCC. The expression of HNF1β and the biliary differentiation marker cytokeratin 19 (CK19) were retrospectively ...
Beca Francisco F http://orcid.org/0000-0002-4409-012X Department of Medical Oncology, Dana-Farber Cancer Institute/Harvard Medical School, Boston, Massachusetts, USA IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal Faculty of Medicine, Department of Pathology and Oncology, University of Porto, Porto, - - 2014
Despite considerable interest in the PI3K/AKT/mTOR pathway in breast carcinomas (BC), published data reports contradictory results regarding the association of phosphorylated mammalian target of Rapamycin (p-mTOR) expression with clinico-pathological features and prognosis in BC. Here, we evaluate the main clinico-pathological associations with p-mTOR expression in BC, with focus on the ...
Kitahashi Tsukasa T From the Central Animal Division, National Cancer Center Research Institute, Tokyo, - - 2014
The aim of the present study was to characterize molecular targets for the prevention/diagnosis of pancreatic cancer using a chemically induced hamster pancreatic carcinogenesis model, in which background injuries to the parenchyma, for example, chronic pancreatitis or acinar atrophy, are limited. Gene expression profiles in atypical hyperplasias were first investigated ...
Ruggieri Simona S Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, - - 2014
Bcl-6 translocation is a genetic alteration that is commonly detected in Primary Central Nervous System Lymphoma. The role of this protein in cerebral tumors is unclear. In this study we investigated Bcl-6 translocation and its transcriptional and translational levels in formalin-fixed, paraffin-embedded cerebral tissue sections from Glioblastoma (GBM), low-grade glioma ...
Dasgupta Subhamoy S S Dasgupta, Molecular and Cellular Biology, Baylor College of Medicine, Houston, United - - 2014
Transcriptional coactivators have evolved as an important new class of functional proteins that participate with virtually all transcription factors and NRs to intricately regulate gene expression in response to a wide variety of environmental cues. Recent findings have highlighted that coactivators are important for almost all biological functions, and consequently, ...
Song Ruipeng R Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, - - 2014
Hepatocellular carcinoma (HCC) is a highly vascularized tumor with frequent extrahepatic metastasis. Active angiogenesis and metastasis are responsible for rapid recurrence and poor survival of HCC. However, the mechanisms that contribute to tumor metastasis remain unclear. Here, we evaluate the effects of ATPase inhibitory factor 1 (IF1), an inhibitor of ...
Morishita Asahiro A Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761-0793, - - 2014
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Despite improvementsin HCC therapy, the prognosis for HCC patients remains poor due to a high incidence of recurrence.An improved understanding of the pathogenesis of HCC development would facilitate the development of moreeffective outcomes for the diagnosis and treatment ...
Ikemoto Tetsuya T Department of Surgery, Institute of Health Biosciences, the University of Tokushima, Kuramoto 3-18-15, Tokushima 770-8503, - - 2014
This study was performed to elucidate the expression of the Notch signaling pathway and its correlations to clinicopathological factors of intraductal papillary mucinous neoplasms (IPMNs).It is incontrovertible that regulatory T cells (Tregs) play an important role in tumor immunity. However, the whole mechanism of control of peripheral Tregs remains unclear. ...
Liu Sheng S aDepartment of Gastrointestinal Surgery, Xiangya Hospital of Central South University bDepartment of Pathology, Hunan Provincial Cancer Hospital, Changsha, - - 2014
Snail, a zinc finger structure transcription inhibitory factor, has been reported to play an important role in the metastatic progression of several types of cancer. The aim of the study was to identify potential biomarkers for metastasis in gastrointestinal stromal tumors (GISTs) by examining the expression levels of Snail, E-cadherin, ...
Shen Yanyun Y Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. - - 2014
Cyclin D1 is a member of the G1 cyclin family that regulates the transition through the G1 phase of the cell cycle and is involved in the neoplastic transformation of certain tumors. This study was designed to investigate the expression of cyclin D1 in Bowen's disease (BD) and cutaneous squamous ...
Zhai Jianwen J Department of Cardiothoracic Surgery, The Affiliated Hospital of Hebei University of Engineering, Handan, Hebei 056002, P.R. - - 2014
It has been shown that death-associated protein kinase (DAPK) family and E-cadherin play significant roles in the promotion of apoptosis and the suppression of cell adhesion and migration, and are involved in tumor metastasis. Ezrin, a cytoplasmic peripheral membrane protein, has been shown to interact with E-cadherin to participate in ...
Li Cong C Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Dong'an road, 270, Shanghai, 200032, - - 2014
Chemoradiotherapy has been commonly used as neoadjuvant therapy for rectal cancer to allow for less aggressive surgical approaches and to improve quality of life. In cancer, it has been reported that CXCL10 has an anti-tumor function. However, the association between CXCL10 and chemoradiosensitivity has not been fully investigated. We performed ...
Mariaselvam Christina Mary CM Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India; INSERM, UMRS 1160, Saint Louis Hospital, Paris F75010, - - 2014
Rheumatoid arthritis (RA), a chronic inflammatory disease affects up to 1% of the general population. Early diagnosis and treatment are limited by the absence of specific and reliable diagnostic/prognostic biomarkers. This study was carried out in 48 Tamil South Indian RA patients and 49 healthy controls (HC) to identify any ...
Stella Flavia F Laboratorio de Genética de Neoplasias Linfoides, Instituto de Medicina Experimental, CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina. Electronic address: - - 2014
In this study, we have examined CKS1B gene expression and copy number in a total of 114- patients at diagnosis: 83 with multiple myeloma (MM) and 31 with monoclonal gammopathy of undetermined significance (MGUS). Results were correlated with cytogenetics, FISH and clinical characteristic. Significant CKS1B mRNA levels in MM compared ...
Douds Jonathan J JJ Departments of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, - - 2014
Previous studies showed that CD200 expression is a prognostic factor for plasma cell myeloma (PCM), but the prognostic effect is conflicting between studies. We studied CD200 protein expression and the stability of expression in PCM to clarify its potential utility in diagnosis, prognosis and monitoring of disease. CD200 expression was ...
Smith Steven Christopher SC 1] Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA [2] Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, - - 2014
Recent molecular advances have identified a novel, clinically aggressive subgroup of undifferentiated round cell sarcomas defined molecularly by oncogenic fusion of the gene, CIC, and either DUX4 or its paralog, DUX4L, herein termed CIC-DUX sarcomas. Morphologically, CIC-DUX sarcomas are round cell sarcomas with high-grade nuclear features, including vesicular chromatin and ...
Nigam Jaya J Department of Surgical Gastroenterology, King George's Medical University, Lucknow, Uttar Pradesh, 226003, - - 2014
Survivin, an inhibitor of apoptosis, has been shown to be expressed in various malignancies. However, its role in gallbladder cancer (GBC) has not been evaluated yet. We investigated its expression in peripheral blood of patients with gallbladder diseases (gallstone disease (GSD), n = 30; GBC, n = 39) and compared with healthy controls (n = 25). ...
Adam Patrick P Institute of Pathology, Ingolstadt, - - 2014
Due to its profound therapeutic consequences, the distinction between thymoma and T-lymphoblastic lymphoma in needle biopsies is one of the most challenging in mediastinal pathology. One essential diagnostic criterion favouring thymoma is the demonstration of increased numbers of keratin-positive epithelial cells by immunohistochemistry. Loss of keratin expression in neoplastic epithelial ...
Sui Lu L Department of Pathophysiology, Shenyang Medical College, Huanghe North Avenue No.146, Shenyang, 110034, People's Republic of China, - - 2014
We carried out the current meta-analysis of relevant cohort studies in an attempt to investigate the relationships between vascular endothelial growth factor (VEGF) expression and pathological characteristics of diffuse large B cell lymphoma (DLBCL). The following electronic databases were searched for relevant articles without any language restrictions: Web of Science ...
Tao Tao T Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, - - 2014
Recent studies have shown that many molecular mechanisms, such as the EGFR, AKT, STAT3, and beta-catenin pathways, are involved in glioma. However, the prognosis of the disease remains poor. Explorations of the underlying mechanisms of glioma and identification of effective markers for early diagnosis and accurate prognostication remain important today. ...
Ishikawa Daichi D The Department of Surgery, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima 770-8503, - - 2014
Intraductal papillary mucinous neoplasm (IPMN) is a well-established entity among pancreatic neoplasms, which ranges from low-grade dysplasia to invasive carcinoma. Epithelial-mesenchymal transition (EMT) contributes to tumor progression in various cancers. Moreover, Notch signaling is one of the important upstream effectors of EMT promotion. Currently, it is unclear whether EMT causes ...
Karli Philemon P Division of Neurological Sciences, Department of Clinical Veterinary Neurology, Vetsuisse Faculty, University of Bern, Switzerland. Electronic address: - - 2014
In canine intervertebral disc (IVD) disease, a useful animal model, only little is known about the inflammatory response in the epidural space. To determine mRNA expression of selected cytokines, chemokines and matrix metalloproteinases (MMP) qualitatively and semi-quantitatively over the course of the disease and to correlate results to neurological status ...
Gungorduk Kemal K Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, - - 2014
To analyze the expression patterns of extracellular signal-regulated kinase (ERK1/2) and phosphorylated (p)-AKT in the tissues of non-pathologic endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer using indirect immunohistochemistry, and also to investigate the effect of ERK1/2 and p-AKT expression patterns on prognosis in endometrioid adenocancer. Immunolocalization ...
Bhandaru Madhuri - - 2014
To date only a handful of drugs are available for the treatment of melanoma. Among them vemurafenib, a BrafV600E specific inhibitor, showed promising results in terms of response rate and increase in median survival time. However, its effectiveness is limited by development of resistance and the search for additional drugs ...
Righi Luisella L From the Departments of Oncology and - - 2014
Malignant pleural mesothelioma (MPM) is a highly aggressive disease for which new prognostic biomarkers need to be identified. Caveolin-1 (CAV1), the most important member of caveolae, has been described as deregulated in MPM at the genomic level, but detailed histologic information on its distribution and prognostic role is still lacking. ...
El-Menshawy Nadia N Mansoura University Faculty of Medicine, Department of Clinical Pathology, Mansoura, - - 2014
Objective: Aberrant activation of transcription factor genes is the most frequent target of genetic alteration in lymphoid malignancies. The lymphoblastic leukemia-derived sequence 1 (LYL1) gene, which encodes a basic helix-loop helix, was first identified with human T-cell acute leukemia. Recent studies suggest its involvement in myeloid malignancies. We aimed to ...
Huang Yuanshen Y Molecular Medicine Lab and Chieng Genomics Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada; Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, - - 2014
Mycosis fungoides (MF) often mimics the common chronic inflammatory skin diseases and is difficult to be diagnosed with certainty, partly because of the lack of well-characterized molecular markers. Previously, we discovered that TOX, a key T cell development regulator,was aberrantly over-expressed in early stage MF. In the current multi-center study ...
Zhuang Zhuo-Nan ZN Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, PR China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, 250012, Shandong, PR - - 2014
Background. Over-expression of integrin β6 plays an important role in a variety of malignant tumor invasion and metastasis. Methods. The expression levels of integrin β6, MMP-2 and MMP-9 were analyzed by immunohistochemistry with human follicular thyroid carcinomas. Then we investigated their correlation with clinical outcomes parameters, relationship and the survival ...
Kaira Kyoichi K Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma, Japan; Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma, - - 2014
ASCT2 is highly expressed in cancer cells. However, the clinicopathological significance of ASCT2 expression in pancreatic cancer remains unclear. The aim of this study was to investigate the clinical significance of ASCT2 expression in pancreatic cancer. Ninety-seven patients with surgically resected pancreatic ductal adenocarcinoma were evaluated. Tumor sections were stained ...
Choi Jung-Woo JW Department of Pathology, Korea University Ansan Hospital, Ansan, Republic of - - 2014
To investigate the prognostic significance of lactate/proton monocarboxylate transporters MCT1, MCT4, and their chaperone CD147 expressions in urothelial carcinoma of the bladder (UCB). We examined the expressions of MCT1, MCT4, and CD147 proteins in a total of 360 cases of UCB by immunohistochemistry. The immunohistochemical expressions were quantified using an ...
Wahid Fazli F Biotechnology Program, COMSATS Institute of Information Technology, Abbottabad, Pakistan. Electronic address: - - 2014
MicroRNA (miRNA) is a small non-coding regulatory RNA of 21-25 nucleotides (nts) in length. miRNA works as a post-transcriptional regulator of a specific mRNA by inducing degradation or translation repression resulting in gene silencing. A large number of miRNA have been reported and many more are yet to be discovered. ...
Hanfstein Benjamin B Universitatsmedizin - - 2014
The vast majority of chronic myeloid leukemia patients express a BCR-ABL1 fusion gene mRNA encoding a 210 kDa tyrosine kinase which promotes leukemic transformation. A possible differential impact of the corresponding BCR-ABL1 transcript variants e13a2 (b2a2) and e14a2 (b3a2) on disease phenotype and outcome is still conflicting. A total of ...
Zhou Zhongren Z Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642. Electronic address: - - 2014
Bile acid reflux into the esophagus is important in the development of esophageal adenocarcinoma (EAC). Recently, vitamin D receptor (VDR) was recognized as a bile acid receptor as well as a vitamin receptor. Expression of VDR is reported to influence the development of various types of cancer, such as those ...
Jiang Wenjie - - 2014
Abstract MicroRNAs (miRNAs) are small RNAs that regulate target gene expression. Using microarray-based miRNA expression profiling, we compared the miRNA expression in granulocytes from 4 acute myeloid leukemia patients and 4 healthy controls. Thirty-four miRNAs were found to be differentially expressed, including 20 miRNAs that were upregulated and 14 miRNAs ...
Rosenkrantz A B AB Department of Radiology, NYU Langone Medical Center, New York, NY, USA. Electronic address: - - 2014
To evaluate the degree of variability in clinicians' interpretation of expressions used by radiologists to communicate their level of diagnostic confidence within radiological reports. Clinicians were solicited to complete a prospective survey asking them to select the approximate perceived level of certainty, expressed as a percentage, associated with 20 expressions ...
CieĊ›la Maciej M Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Gronostajowa 7, 30-387 Krakow, - - 2014
Rhabdomyosarcoma is the most common type of soft tissue sarcoma in children. Two main subtypes of rhabdomyosarcoma with different molecular pattern and distinct clinical behaviour may be identified-embryonal and alveolar rhabdomyosarcoma. All types of rhabdomyosarcoma are believed to be of myogenic origin as they express high levels of myogenesis-related factors. ...
Rosner Karli K Department of Dermatology, Wayne State University, 110, East Warren Avenue, Detroit, MI 48201; Center for Molecular Medicine and Genetics, Wayne State University, 110, East Warren Avenue, Detroit, MI 48201; Karmanos Cancer Institute, Wayne State University, 110, East Warren Avenue, Detroit, MI 48201. Electronic address: - - 2014
Melanoma is the leading cause of death from skin cancer in industrialized countries. Several melanoma-related biomarkers and signaling pathways have been identified; however, their relevance to melanoma development/progression or to clinical outcome remains to be established. Aberrant activation of Wnt/β-catenin pathway is implicated in various cancers including melanoma. We have ...
Rüping Katinka K Institute of Pathology, Friedrich-Schiller University, Jena, - - 2014
Pleomorphic undifferentiated sarcomas (formerly known as malignant fibrous histiocytomas) are recognised by the actual WHO classification as an undifferentiated, unclassifiable category of pleomorphic sarcomas which show no definable line of differentiation and are still a diagnosis of exclusion. Therefore, diagnostic, prognostic and therapeutic options of these tumours are urgently needed. ...
González-Andrade Pablo P Biomedical Sciences Department, Institute of Tropical Medicine, Antwerp, - - 2014
Trypanosomatids transcribe their genes in large polycistronic clusters that are further processed into mature mRNA molecules by trans-splicing. During this maturation process, a conserved spliced leader RNA (SL-RNA) sequence of 39 bp is physically linked to the 5' end of the pre-mRNA molecules. Trypanosomatid infections cause a series of devastating ...
Mourra Najat N Departments of Pathology, St-Antoine Hospital, Paris, - - 2014
Clusterin (CLU) is a sulfated glycoprotein implicated in many physiological and pathological processes, including tumorigenesis. We have previously demonstrated that CLU is highly expressed, in pancreatic neuroendocrine tumours (NETs). Here we investigate its expression in gastrointestinal NETs, the potential correlation between this expression and different clinicopathologic parameters and its usefulness ...
Fu Rong-Dang RD Department of Hepatic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, - - 2014
Retinoic acid receptor-related receptor alpha (RORalpha) has been proven to play a tumor suppressive role in certain types of solid tumors. However, the clinical characteristic of RORalpha has not been reported by far. This study investigated the expression of RORalpha in hepatocellular carcinoma (HCC) and evaluated its relationship with clinical ...
Chen Guo G Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer - - 2014
An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between brain and extracranial metastases would support the need for the development ...
Pandi Narayanan Sathiya NS Unit of Rural Biotechnology, Saraswathi Narayanan College, Madurai 625022, India. Electronic address: - - 2014
Actin-binding protein anillin (ANLN) is primarily involved in the cytokinesis and known to be dysregulated in many cancers including gastric cancer (GC). However, the regulation and clinical significance of ANLN in GC are far less clear. In the present study, we aimed to investigate the clinical significance and possible regulators ...
Honkaniemi Emma E 1Department of Pediatrics, Astrid Lindgren Children`s Hospital, Karolinska University Hospital-Huddinge, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, - - 2014
Background: Alterations in the tumor suppressor gene TP53 have been associated with poor outcome in adult hematological malignancies. We have earlier reported an increased expression of the TP53 encoded protein p53, in bone marrow samples from pediatric patients with aggressive leukemia. Our aim was now to evaluate p53 protein expression ...
Loures Luciano Fernandes LF Department of Obstetrics and Gynecology, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, - - 2014
To investigate protein expression and mutations in phosphatase and tensin homolog (PTEN) in patients with stage IB cervical squamous cell carcinoma (CSCC) and the association with clinical-pathologic features, tumor p53 expression, cell proliferation and angiogenesis. Women with stage IB CSCC (n=20 - Study Group) and uterine myoma (n=20 - Control ...
Honardoost Mohammad Amin MA Division of Cellular and Molecular Biology, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, - - 2014
Multiple sclerosis is an inflammatory autoimmune disease widely characterized by myelin destruction of CNS. Th-17 cells, have been demonstrated to play a crucial role in pathogenesis of MS. MicroRNAs are a new class of non-coding RNAs that participate in post-transcriptional regulation of gene expression. Previous studies have reported a potential ...
Linnertz Colton C Department of Neurology, Duke University Medical Center, Durham, NC 27710, - - 2014
The molecular genetic basis that leads to Lewy Body (LB) pathology in 15-20% of Alzheimer disease cases (LBV/AD) was largely unknown. Alpha-synuclein (SNCA) and Leucine-rich repeat kinase2 (LRRK2) have been implicated in the pathogenesis of Parkinson's disease (PD), the prototype of LB spectrum disorders. We tested the association of SNCA ...
Galac S S Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address: - - 2014
We report on a screening for the relative messenger RNA (mRNA) and protein expression of steroidogenic factor 1 (SF-1) in normal canine adrenals (n = 10) and cortisol-secreting adrenocortical tumors (11 adenomas and 26 carcinomas). The relative mRNA expression of SF-1 was determined by quantitative real-time polymerase chain reaction analysis ...
Guled Mohamed M Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, - - 2014
The rare and highly aggressive adult soft tissue sarcomas leiomyosarcoma (LMS) and undifferentiated pleomorphic sarcoma (UPS) contain complex genomes characterized by a multitude of rearrangements, amplifications, and deletions. Differential diagnosis remains a challenge. MicroRNA (miRNA) profiling was conducted on a series of LMS and UPS samples to initially investigate the ...
Duregon Eleonora E Department of Oncology, University of Turin at San Luigi Hospital, Orbassano, 10043, Torino, - - 2014
Several microRNAs (miRNAs) were shown to be deregulated in adrenocortical carcinoma (ACC) as compared with adenoma, but a detailed assessment of their expression in its histologic variants and correlation with clinicopathologic characteristics has not been performed, so far. Our aim was to assess the expression of 5 selected miRNAs (IGF2 ...
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