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Portelli Michael A MA University of Nottingham, Division of Respiratory Medicine , D Floor South Block , Queens Medical Centre , Nottingham, Nottinghamshire, United Kingdom , NG7 2UH , 441158231069 ; - - 2014
The urokinase plasminogen activator receptor (uPAR) gene (PLAUR) has been identified as an asthma susceptibility gene, with polymorphisms within that gene being associated with baseline lung function, lung function decline and lung function in a smoking population. Soluble cleaved uPAR (scuPAR), a molecule identified as a marker of increased morbidity ...
Li Zhipeng Z Department of Otorhinolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. - - 2014
Interleukin (IL)-25, a cytokine of IL-17 family, can activate p38 Mitogen-Activated Protein kinases(MAPK) and Nuclear Factor(NF)-κB pathways to propagate Th2 responses. The allergic rhinitis mouse model was established by stimulating BALB/c mouse with ovalbumin (OVA). Then we detected expression of IL-25 and downstream p38MAPK and NF-κB. The expression of IL-25, ...
Zhang Xiangfeng X Department of Respiratory Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. Email: - - 2014
Exposure of adult mice to more than 95% O2 produces a lethal injury by 72 hours. Nuclear factor kappa B (NF-κB) is a transcriptional factor that plays a key role in the modulation of cytokine networks during hyperoxia-induced acute lung injury (ALI). Osteopontin (OPN) is a phosphorylated glycoprotein produced principally ...
Choi Y S - - 2014
The variety of beneficial effects of green tea has been reported. Epigallocatechin-3-gallate (EGCG) is a major component of green tea extract. The biological activity of EGCG includes anti-allergic and anti-inflammatory activities. However, the precise effect of EGCG on the allergic airway inflammation has not been fully defined. In lung tissues ...
Karnik Sonali S Center for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Ruston, LA, - - 2014
An alginate/halloysite nanotube nanocomposite was developed with sustained release of bone morphogenetic proteins (BMPs) at picogram low levels. BMP-2, 4, and 6 and osteoblasts were chosen as our model 'growth factor' and 'cell type' as the interaction of BMPs with osteoblasts is well known and thoroughly investigated. Alginate hydrogels with ...
Wu Li-Qin LQ Department of Pulmonary Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou City, - - 2014
Roxithromycin (RXM) expresses anti-asthmatic effects that are separate from its antibiotic activity, but its effects on airway remodeling are still unknown. Here, we evaluated the effects of RXM on airway remodeling and the expression of caveolin-1 and phospho-p42/p44mitogen-activated protein kinase (phospho-p42/p44MAPK) in chronic asthmatic rats. The chronic asthma was induced ...
Fischer Kimberly D - - 2014
BackgroundSubepithelial fibrosis is a characteristic hallmark of airway remodeling in asthma. A critical regulator of fibrosis, transforming growth factor ß (TGF-ß), can induce airway remodeling in epithelial cells through induction of epithelial-mesenchymal transition (EMT). Vitamin D has immunomodulatory functions, however, its effect on controlling subepithelial fibrosis is not known.MethodsHuman bronchial ...
Chang Po-Jui PJ Chang Gung University College of Medicine, Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan ; - - 2014
Rationale: Patients with severe asthma (SA) are less responsive to the beneficial effects of corticosteroid (CS) therapy and relative CS insensitivity has been shown in airway smooth muscle cells (ASMC) from SA patients. Objectives: We investigated whether there was a defect in the actions of the glucocorticoid receptor (GR) underlying ...
Korbecki Jan J Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111, Szczecin, Poland, - - 2014
Vanadium is a metal present in air pollution. Its compounds may have both anticancer and carcinogenic properties. Vanadium compounds are tested in treatment of diabetes and cancer. An important research direction aimed at better understanding of the mechanisms of action of the vanadium compounds is a more detailed insight into ...
Sorbello Valentina V Department of Clinical and Biological Sciences, University of Torino, - - 2014
Severe asthma (SA) is associated with neutrophil recruitment and T helper (TH )17 chemokine over-expression in bronchial biopsies. We aimed to evaluate IL-17A and IL-17F expression in nasal/bronchial lamina propria of atopic mild-to-severe asthmatics and controls in relation to neutrophilia and asthma exacerbations. Cryostat sections of nasal/bronchial biopsies obtained from ...
Adelibieke Yelixiati Y Department of Advanced Medicine for Uremia, Nagoya University Graduate School of Medicine, Nagoya, - - 2014
Background/Aims: Interleukin-6 (IL-6) is one of the inflammation biomarkers with highest predictive value for outcome in chronic kidney disease (CKD) patients. The present study aimed to determine the effects of indoxyl sulfate (IS) on IL-6 expression in vascular cells. Methods: IS was administered to normo- and hypertensive rats. Human umbilical ...
Kennedy Lindsey L LL Digestive Disease Research Center, Central Texas Veterans Health Care System, Temple, TX, - - 2014
Cholangiopathies are characterized by dysregulation of the balance between biliary growth and loss. We have shown that histamine (HA) stimulates biliary growth via autocrine mechanisms. To evaluate the paracrine effects of mast cell (MC) stabilization on biliary proliferation, sham or BDL rats were treated by IP-implanted osmotic pumps filled with ...
Herber-Jonat Susanne S 1Division of Neonatology, Dr. von Hauner Children's Hospital, Perinatal Center Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany. 2Laboratory of Physiology and Physiopathology, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium. 3Comprehensive Pneumology Center, University Hospital, Ludwig-Maximilian-University and Helmholtz Centre, Munich, Germany. 4Department of Obstetrics and Gynecology, University Hospital Brugmann, Brussels, - - 2014
Fetal tracheal occlusion of hypoplastic rabbit lungs results in lung growth and alveolarization although the surfactant protein messenger RNA expression is decreased and the transforming growth factor-β pathway induced. The prenatal filling of healthy rabbit lungs with perfluorooctylbromide augments lung growth without suppression of surfactant protein synthesis. We hypothesizes that ...
Sueblinvong Viranuj V Division of Pulmonary, Allergy & Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, - - 2014
Chronic alcohol ingestion induces the expression of transforming growth factor beta-1(TGFβ1), inhibits nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated activation of the antioxidant response element (ARE), depletes alveolar glutathione pools, and potentiates acute lung injury. In this study, we examined the mechanistic relationship between TGFβ1 and Nrf2-ARE signaling in the experimental ...
Wages Phillip A PA Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC, - - 2014
Human exposure to particulate matter (PM) is a global environmental health concern. Zinc (Zn(2+)) is a ubiquitous respiratory toxicant that has been associated with PM health effects. However, the molecular mechanism of Zn(2+) toxicity is not fully understood. H2O2 and Zn(2+) have been shown to mediate signaling leading to adverse ...
Li Wenlei W Center of Pediatric Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, - - 2014
After surgery performed under cardiopulmonary bypass (CPB), severe lung injury often occurs in infants. MicroRNAs (miRNAs) are potentially involved in diverse pathophysiological processes via regulation of gene expression. The objective of this study was to investigate differentially expressed miRNAs and their potential target genes in immature piglet lungs in response ...
Zhou Pang-Hu PH Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. - - 2014
The aim of the study was to determine whether the controlled release of interleukin (IL)‑1Ra from chitosan (CS) microspheres inhibits the IL‑1β‑stimulated production of matrix metalloproteinases (MMPs) in chondrocytes. The CS‑IL‑1Ra microspheres were fabricated by an emulsification method using sodium tripolyphosphate as a crosslinker, and the controlled release of IL‑1Ra ...
Friedmacher Florian F National Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin 12, - - 2014
Pulmonary hypoplasia (PH), characterized by alveolar immaturity, is one of the leading causes of respiratory insufficiency in newborns with congenital diaphragmatic hernia (CDH). Leptin (Lep) and its receptor (Lep-R) play an important role in fetal lung growth by stimulating alveolar differentiation and maturation. Lep and Lep-R are strongly expressed by alveolar ...
Li Yaqing - - 2014
BackgroundIn chronic obstructive pulmonary disease (COPD), two major pathological changes that occur are the loss of alveolar structure and airspace enlargement. To treat COPD, it is crucial to repair damaged lung tissue and regenerate the lost alveoli. Type II alveolar epithelial cells (AECII) play a vital role in maintaining lung ...
Gaspar-Ramírez Octavio O Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí , San Luis Potosí , México - - 2014
Abstract Recent studies have demonstrated that compounds inducing pro-inflammatory cytokines enhance AhR expression. The aim of this study was 2-fold: (1) to determine if two pro-inflammatory compounds, dichlorodiphenyldichloroethylene (DDE) and 2,2',4,4',5,5'-hexa-chlorobiphenyl (PCB 153), independently affect AhR gene expression in peripheral blood mononuclear cells (PBMC); and (2) if affected, to determine ...
Hou Xiaoxia X Department of Pulmonary Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, - - 2014
To investigate the expression pattern of histone deacetylase 9 in peripheral blood of patients with allergic asthma and its regulatory effect on the balance of Th17/Treg cells involved in the pathogenesis of asthma. FUGW vector was used to construct the Jurkat-HA-FOXP3 cell line. After histone deacetylase inhibitor-trichostatin A (TSA) treatment, ...
Qian J J Department of Emergency Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, - - 2014
Toll-like receptor 9 (TLR9), an important component of the innate immune system, contributes to the pathogenesis of lung injury. However, its role in paraquat (PQ)-induced lung injury has not been studied. Mice were divided into PQ group (n = 24) and control group (n = 12). Mice in both groups ...
Xie Min M Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; University of Pittsburgh Asthma Institute@UPMC, Pulmonary Allergy Critical Care Medicine Division, Department of Medicine, University of Pittsburgh, Pittsburgh, - - 2014
Severe asthma (SA) can involve both innate and type 2 cytokine-associated adaptive immunity. Although IL-27 has been reported to potentiate TH1 responses (including the chemokine CXCL9) and suppress TH2 responses, its function in asthmatic patients is unknown. We sought to evaluate IL-27 expression in human asthma alone and in combination ...
Patel Brijeshkumar S BS University of Sydney, Faculty of Pharmacy, Sydney, New South Wales, Australia ; - - 2014
β2-agonists are principally used in asthma to provide bronchodilation, however they also have anti-inflammatory properties due, in part, to their ability to upregulate mitogen-activated protein kinase phosphatase 1 (MKP-1) in a cAMP-dependent manner. Phosphodiesterases (PDEs) are attractive targets for potentiating the anti-inflammatory response. There are 11 subfamilies of PDE enzymes, ...
Govitvattana Nattanan N Research Unit of Mineralized Tissue, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; Graduate Program in Oral Biology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Electronic address: - - 2015
To investigate the relationship between ATP and IL-6 in mechanical stress-induced REX-1 expression in SHEDs. Cells were stimulated with mechanical stress (0-2.5gcm(-2)), IL-6 (0.1-5ng/ml), or ATP (10-100μM) for 2h in serum-free media. IL-6 and REX-1 expression was examined by qualitative and quantitative polymerase chain reaction. ATP release was measured using ...
Hao Yonghua Y Department of Pathobiology, University of Illinois at Urbana-Champaign, - - 2014
Aberrant mucin secretion and accumulation in the airway lumen are clinical hallmarks associated with various lung diseases, such as asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Mycoplasma pneumoniae (MP), long appreciated as one of the triggers for acute exacerbations of chronic pulmonary diseases, has recently been reported ...
Shiono Osamu O Department of Otorhinolaryngology and Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan; Department of Otorhinolaryngology, and Head and Neck Surgery, Yokohama City University Medical Center, Yokohama, Japan. Electronic address: - - 2014
Chronic rhinosinusitis (CRS) is thought to be a multifactorial disease, and it is classified into a number of subtypes according to clinicohistological features. Periostin, a 90-kDa secreted protein, was reported to exist in nasal polyps (NPs) associated with CRS. We compared the expression of periostin with the degree of eosinophilic ...
Zhang Zhaolin Z Northwestern University, Lurie Children's Research Center, Chicago, Illinois, United States ; - - 2014
Cystic fibrosis transmembrane conductance regulator gene (CFTR) expression in human airway epithelial cells involves the recruitment of distal cis-regulatory elements, which are associated with airway-selective DNase hypersensitive sites (DHS) at -44kb and -35kb from the gene. The -35kb site encompasses an enhancer that is regulated by the immune mediators Interferon ...
Melboucy-Belkhir Sara S INSERM UMR - - 2014
Aberrant expression of master phenotype regulators by lung fibroblasts may play a central role in idiopathic pulmonary fibrosis (IPF). Interrogating IPF fibroblast transcriptome datasets, we identified Forkhead Box F1 (FOXF1), a DNA-binding protein required for lung development, as a candidate actor in IPF. Thus, we determined FOXF1 expression levels in ...
Cao Qingsong Q Department of Otorhinolaryngology, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, - - 2014
The expression and distribution of signal transducer and activator of transcription 3 (STAT3), phosphorylated STAT3 (p-STAT3), and vascular endothelial growth factor (VEGF), as well as eosinophil infiltration in nasal polyps was detected to examine their roles and correlations in the nasal polyp pathogenesis. Using the streptavidin-biotin-peroxidase (SP) method, immunohistochemistry was ...
Lin Hai H Department of Otorhinolaryngology, Eye and ENT Hospital of Fudan University, Shanghai, China; Department of Otorhinolaryngology, Fuzhou General Hospital, Fuzhou, Fujian, - - 2014
The pathogenesis of human chronic rhinosinusitis with nasal polyps (CRSwNP) comprising eosinophilic CRSwNP (ECRSwNP) and non-eosinophilic (nECRSwNP) is not completely understood. Recent evidence has suggested that platelet-derived growth factor receptor alpha (PDGFRα) is implicated in cell growth, transformation, proliferation, migration, and vascular permeability and platelet-derived growth factor-A (PDGF-A) is a ...
Lin Hai H Department of Otorhinolaryngology, Eye and ENT Hospital of Fudan University, Shanghai, China Department of Otorhinolaryngology, Fuzhou General Hospital, Fuzhou, Fujian, - - 2014
The pathogenesis of human chronic rhinosinusitis with nasal polyps (CRSwNP) remains undetermined. Livin is a member of the inhibitor of the apoptosis protein family proteins. Caspase-3 and second mitochondria-derived activator of caspases (Smac) are critical in the induction of apoptosis. However, little is known about their roles in CRSwNP. We ...
Cho See-Wun SW Department of Life and Nanopharmaceutical Science, Kyung Hee University, Hoegi Dong, Dongdaemun-Gu, Seoul, 130-701, - - 2014
The aryl hydrocarbon receptor (AHR) is responsible for susceptibility to its ligand-dependent responses. However, the effect of non-AHR factors is less clear. To explore the non-AHR factors, we used two mouse strains with different AHR genetic variants, namely C3H/lpr and MRL/lpr strains with Ala and Val as the 375th amino ...
Comer Brian S BS University of South - - 2014
MicroRNA(miR)-146a and miR-146b are negative regulators of inflammatory gene expression in lung fibroblasts, epithelial cells, monocytes, and endothelial cells. The abundance of cyclooxygenase-2 (COX-2) and IL-1β is negatively regulated by the miR-146 family, suggesting miR-146a and/or miR-146b might modulate inflammatory mediator expression in airway smooth muscle thereby contributing to pathogenesis ...
Boivin Roxane R Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, St-Hyacinthe, Quebec, - - 2014
Overexpression of the (+)insert smooth muscle myosin heavy chain (SMMHC) isoform could contribute to airway bronchospasm by increasing the velocity of contraction. Whether the (+)insert isoform is present in the small airways and its expression is reversible in asthma are unknown. To determine the anatomical location and the expression kinetics ...
François Déborah D 1] INSERM, U1148-LVTS, F-75018 Paris, France, Université Paris Diderot, Sorbonne Paris Cité, Paris, France [2] DHU FIRE, Paris, - - 2014
Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse lung disease characterized by an accumulation of excess fibrous material in the lung. Protease nexin-1 (PN-1) is a tissue serpin produced by many cell types, including lung fibroblasts. PN-1 is capable of regulating proteases of both coagulation and fibrinolysis systems, by inhibiting, ...
Gardini Alessandro A Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; The Wistar Institute, Philadelphia, PA 19104, - - 2014
In unicellular organisms, initiation is the rate-limiting step in transcription; in metazoan organisms, the transition from initiation to productive elongation is also important. Here, we show that the RNA polymerase II (RNAPII)-associated multiprotein complex, Integrator, plays a critical role in both initiation and the release of paused RNAPII at immediate ...
Homma Tetsuya T Northwestern University, Allergy and Immunology, Chicago, Illinois, United States, Showa University, Tokyo, Japan ; - - 2014
Rationale: Staphylococcus aureus (SA) colonization and infection is common and may promote allergic or inflammatory airway diseases such as asthma, cystic fibrosis, and chronic rhinosinusitis (CRS) by interacting with airway epithelial cells. Airway epithelial cells not only comprise a physical barrier, but also play key roles in immune, inflammatory, repair ...
Comer Brian S BS University of South Alabama, Dept. of Biochemistry and Molecular Biology, Mobile, Alabama, United States ; - - 2014
Cyclooxygenase-2 expression and PGE2 secretion from human airway smooth muscle cells (hASMCs) may contribute to β2-adrenoceptor hyporesponsiveness, a clinical feature observed in some patients with asthma. HASMCs from patients with asthma exhibit elevated expression of cytokine-responsive genes and in some instances this is attributable to an altered histone code and/or ...
Dileepan Mythili - - 2014
BackgroundThe cell-surface protein CD38 mediates airway smooth muscle (ASM) contractility by generating cyclic ADP-ribose, a calcium-mobilizing molecule. In human ASM cells, TNF-¿ augments CD38 expression transcriptionally by NF-¿B and AP-1 activation and involving MAPK and PI3K signaling. CD38 ¿/¿ mice develop attenuated airway hyperresponsiveness following allergen or cytokine challenge. The ...
Hecht Emelia E Department of Medicine, McGill University, Montreal, Quebec, - - 2014
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor implicated in the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics such as dioxin inhibits the cell cycle and control apoptosis, paradoxically, AhR expression also promotes cell proliferation and survival independent of exogenous ligands. The microRNA ...
Giannetti M M Division of Allergy-Immunology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, - - 2014
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized pathologically by eosinophil infiltration. In addition to loss of barrier integrity, a dominant T Helper 2-associated immune response and strong allergic connection, the esophagus tissue undergoes dramatic changes, with frequent presence of mucosal rings, strictures, linear furrows, and trachealization. Although the ...
Graf Allyson A Central Texas Veteran's Health Care System/Scott & White - - 2014
Background: Histidine is converted to histamine by histidine decarboxylase (HDC). We have shown that cholangiocytes (i) express HDC; (ii) secrete histamine; and (iii) proliferate after histamine treatment via ERK1/2 signaling. In bile duct ligated (BDL) rodents, there is enhanced biliary hyperplasia, HDC expression and histamine secretion. Aim: to demonstrate that ...
Fonseca Linda L Texas Perinatal Group , Austin, TX , USA - - 2014
Abstract Objective: While prenatal administration of synthetic corticosteroids stimulates both fetal lung development and expression of pulmonary surfactant, the specific effects may depend on the corticosteroid formulation used. We compared the dose-dependent effects of various concentrations of two synthetic corticosteroids, betamethasone and dexamethasone, on steady state levels of surfactant protein ...
Herman Melissa A MA Neuroscience Research Center and NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, 10117 Berlin, - - 2014
The vesicular glutamate transporter (VGLUT) plays an essential role in synaptic transmission by filling vesicles with glutamate. At mammalian synapses, VGLUT expression level determines the amount of glutamate packaged into vesicles, and the specific paralog of VGLUT expressed affects the release probability. In this study, we investigate whether there is ...
Li Jian J Jinan Centre for Disease Control and Prevention, Jinan, Shandong 250001, P.R. - - 2014
β-catenin contributes to the pathogenesis of lung fibrosis. However, the expression of β-catenin in fibroblasts under fibrotic conditions has not been studied. We investigated the expression of β-catenin in lung fibroblasts from bleomycin (BLM)‑challenged mice and human lung fibroblasts treated with transforming growth factor β (TGF-β) or lysophosphatidic acid (LPA) ...
Luo Lei L Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306, - - 2014
Corticotropin-releasing hormone (CRH), urotensin I (UI) and urotensin II (UII) are found throughout vertebrate species from fish to human. To further understand the role of crh, uI and uII in teleosts during development, we investigated the expression pattern of crh, uI, uIIα and uIIβ genes, and their response to acute ...
Hayashi Genki G Department of Molecular Biosciences - - 2014
An inherited deficiency of the mitochondrial protein frataxin causes Friedreich's ataxia (FRDA); the mechanism by which this deficiency triggers neuro- and cardio-degeneration is unclear. Microarrays of neural tissue of animal models of the disease showed decreases in antioxidant genes, and increases in inflammatory genes. Cyclooxygenase (COX)-derived oxylipins are important mediators ...
Jeong Jae Hyeok JH Department Obstetrics and Gynecology, Pusan National University, School of Medicine, Yangsan, - - 2014
We examined the effect of sildenafil citrate on advanced glycation end products (AGEs)-induced soluble fms-like tyrosine kinase 1 (sFlt-1) release in JEG-3 choriocarcinoma cells. Cells were incubated with control bovine serum albumin (BSA) or AGEs-BSA, and expression of sFlt-1 mRNA and protein release was determined by quantitative reverse transcription-polymerase chain ...
Masuda Keiko K Section of Behavioral Sciences, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, - - 2014
Neurotensin (NT) and neurotensin-related peptide (Lys(8), Asn(9), NT(8-13): LANT-6) have previously been purified from chicken intestine. However, the presence of these peptides and the localization of their precursor mRNA in the brain were not well understood. In the present study, through a comprehensive analysis of bioactive substances, NT and LANT-6 ...
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