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Sun Shengming S Agriculture Ministry Key Laboratory of Healthy Freshwater Aquaculture, Zhejiang Institute of Freshwater Fisheries, Huzhou 313001, China; Key Laboratory of Genetic Breeding and Aquaculture Biology of Freshwater Fishes, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, - - 2014
Ferritin, a major iron storage protein in most living organisms, plays a crucial role in iron metabolism. In this study, the ferritin subunit MnFer was identified in the oriental river prawn (Macrobrachium nipponense) and functionally characterized. The full-length cDNA of MnFer is 999 bp in size with a 122-bp 5'-untranslated ...
Xiao Guiran G State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences , Tsinghua University , Beijing , - - 2014
The intracellular iron transfer process is not well understood and the identity of the iron transporter responsible for iron delivery to the secretory compartments remains elusive. Here we show Drosophila ZIP13 (Slc39a13), a presumed zinc importer, fulfills the iron effluxing role. Interfering with dZIP13 expression causes iron-rescuable iron absorption defect, ...
Zumbrennen-Bullough Kimberly K Massachusetts General Hospital, Harvard Medical School, United - - 2014
Systemic iron balance is controlled by the liver peptide hormone hepcidin, which is transcriptionally regulated by the bone morphogenetic protein (BMP)-SMAD pathway. In iron deficiency, liver BMP-SMAD signaling and hepcidin are suppressed as a compensatory mechanism to increase iron availability. MicroRNAs (miRNAs) are small regulatory RNAs that have an increasingly ...
Gaun Vera V Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, United States; Department of Medicine, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, United - - 2014
Hepcidin, a peptide hormone produced in the liver, decreases intestinal iron absorption and macrophage iron release via effects on ferroportin. Bone morphogenic protein and Stat3 signaling regulate Hepcidin's transcription. Hepcidin is a potential drug target for patients with iron overload syndromes because its levels are inappropriately low in these individuals. ...
Gulec Sukru S University of - - 2014
Iron is an essential trace mineral that plays a number of important physiologic roles in humans, including oxygen transport, energy metabolism and neurotransmitter synthesis. Iron absorption by the proximal small bowel is a critical check point in the maintenance of whole-body iron levels as, unlike most other essential nutrients, no ...
Shanmugam Nanda Kumar N NK Department of Pediatrics, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129; - - 2014
States of chronic inflammation such as inflammatory bowel disease are often associated with dysregulated iron metabolism and the consequent development of an anemia that is caused by maldistribution of iron. Abnormally elevated expression of the hormone hepcidin, the central regulator of systemic iron homeostasis, has been implicated in these abnormalities. ...
Arenas-Hernández Margarita M P MM Posgrado en Microbiología, Benemérita Universidad Autónoma de Puebla, Apartado Postal, 1622, Puebla, Puebla, México; Licenciatura en Biomedicina, Benemérita Universidad Autónoma de Puebla, Apartado Postal 1622, Puebla, Puebla, México; Centro de Investigaciones en Ciencias Microbiológicas, Benemérita Universidad Autónoma de Puebla, Apartado Postal 1622, Puebla, Puebla, - - 2014
The molecular mechanisms controlling expression of the Long Polar Fimbriae 2 (Lpf2) of enterohemorrhagic E. coli (EHEC) O157:H7 were evaluated. Primer extension was used to locate the lpfA2 transcriptional start site in EHEC strain EDL933 at 171 bp upstream of the lpfA2 start codon. Semi-quantitative RT-PCR demonstrated that the highest ...
Nishimura Kazuhiko K Laboratory of Bioenvironmental Sciences, Course of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku Ohrai-Kita, Izumisano, Osaka, 598-8531, - - 2014
Erythropoietin (EPO) and iron are both indispensable hematopoietic factors and are often studied in humans and rodents. Iron activates prolyl hydroxylases (PHDs) and promotes the degradation of the α-subunit of hypoxia inducible factor (HIF), which regulates EPO production. Iron also causes oxidative stress. Oxidative stress leads to alterations in the ...
Moya Diana D Department of Pediatrics, SUNY at Buffalo, United States; Digestive Diseases and Nutrition Center, Women and Children's Hospital of Buffalo, United - - 2014
Iron may be an important factor in the pathogenesis of non-alcoholic steatohepatitis (NASH) as it catalyzes the production of potent reactive oxygen species. We aim to examine iron status in pediatric NASH. Serum indices of NASH patients (N = 36) were compared to those in the U.S. National Health and Nutrition Examination ...
Wang Xunde X National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United - - 2014
In adults with sickle cell disease (SCD), markers of iron burden such as serum ferritin are associated with excessive production of the angiogenic protein placenta growth factor (PlGF) and high estimated pulmonary artery pressure. Enforced PlGF expression in mice stimulates production of the potent vasoconstrictor endothelin-1, producing pulmonary hypertension. We ...
Przybyszewska Justyna J Department of Nutrition and Dietetics, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, - - 2014
introduction and objective. The clinical consequences of malnutrition are multi-directional and result in dysfunctions of the majority of internal organs and systems. The results of recent studies suggest that a significant role is played by malnutrition in pathophysiology of iron homeostasis disorders, but the underlying mechanism is unclear. The study ...
Padula Maria Carmela MC Department of Science, University of Basilicata, Viale dell'Ateneo Lucano, 85100 Potenza, Italy. Electronic address: - - 2014
HFE-hemochromatosis (HH) is an autosomal disease characterized by excessive iron absorption. Homozygotes for H63D variant, and still less H63D heterozygotes, generally do not express HH phenotype. The data collected in our previous study in the province of Matera (Basilicata, Italy) underlined that some H63D carriers showed altered iron metabolism, without ...
Jeong S M SM Department of Cell Biology, Harvard Medical School, Boston, MA, - - 2014
Iron metabolism is essential for many cellular processes, including oxygen transport, respiration and DNA synthesis, and many cancer cells exhibit dysregulation in iron metabolism. Maintenance of cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which control the expression of iron-related genes by binding iron-responsive elements (IREs) of target ...
Parrow Nermi L NL Division of Molecular and Clinical Nutrition, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD - - 2014
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGF-β) superfamily of signaling molecules. In addition to protean roles in embryonic development, germ-line specification, and cellular differentiation, a central role in iron homeostasis has recently been demonstrated for certain BMPs. Specifically, BMP6 serves to relate hepatic iron stores ...
Dostalikova-Cimburova Marketa M Department of Cell and Molecular Biology, Third Faculty of Medicine, Charles University Prague, Prague, Czech - - 2014
Patients with alcoholic liver disease (ALD) often display disturbed iron indices. Hepcidin, a key regulator of iron metabolism, has been shown to be down-regulated by alcohol in cell lines and animal models. This down-regulation led to increased duodenal iron transport and absorption in animals. In this study, we investigated gene ...
Foster Andrew W AW Department of Chemistry, School of Biological and Biomedical Sciences, Durham University, Durham, DH1 3LE, - - 2014
The extreme resistance of Saccharomyces cerevisiae to copper is overcome by 2-(6-benzyl-2-pyridyl)quinazoline (BPQ), providing a chemical-biology tool which has been exploited in two lines of discovery. First, BPQ is shown to form a red (BPQ)2 Cu(I) complex and promote Ctr1-independent copper-accumulation in whole cells and in mitochondria isolated from treated ...
Lortz S S Hannover Medical SchoolInstitute of Clinical Biochemistry, 30623 Hannover, Germany - - 2014
Free intracellular ferrous iron (Fe(2) (+)) is essential for the generation of the extremely toxic hydroxyl radicals, which contribute to β-cell destruction by cytokines. Therefore the expression of the different divalent metal transporter 1 (Dmt1) isoforms and ferritin (Ft) subunits, responsible for iron import and chelation, was analyzed under pro-inflammatory ...
Yin Dan D Huazhong University of Science and - - 2014
Variants in 37 genes have been associated with low density lipoprotein cholesterol (LDL-C) levels, including HFE (High Fe) p.(C282Y), rs1800562. This variant is homozygous in ~90% patients with haemochromatosis. It may reduce signalling to hepcidin, increasing iron absorption. However it has an extended founder haplotype and the mechanism leading to ...
Goralska Małgorzata M Department of Molecular Biomedical Sciences, North Carolina State University, 1060 William Moore Dr Raleigh, NC 27607, USA. Electronic address: - - 2014
Hypoxia inducible factor (HIF) regulates expression of over 60 genes by binding to hypoxia response elements (HRE) located upstream of the transcriptional start sites. Many genes encoding proteins involved in iron transport and homeostasis are regulated by HIF. Expression of iron handling proteins can also be translationally regulated by binding ...
Mesquita S D SD 0000000207865010 1] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal [2] ICVS/3B's-PT Government Associate Laboratory, Guimaraes, - - 2014
The production, accumulation and aggregation of amyloid beta (Aβ) peptides in Alzheimer's disease (AD) are influenced by different modulators. Among these are iron and iron-related proteins, given their ability to modulate the expression of the amyloid precursor protein and to drive Aβ aggregation. Herein, we describe that lipocalin 2 (LCN2), ...
Tsanova Borislava B Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston and The University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, - - 2014
RNA degradation plays important roles for maintaining temporal control and fidelity of gene expression, as well as processing of transcripts. In Saccharomyces cerevisiae the RNA exosome is a major 3'-to-5' exoribonuclease and also has an endonuclease domain of unknown function. Here we report a physiological role for the exosome in ...
Pandey Satya Deo SD Department of Animal Sciences, Univerisity of Hyderabad, - - 2014
The influence of iron levels on the transcription of hupB gene in Mycobacterium tuberculosis is the focus of this study. Studies in our lab showed HupB to be co-expressed with the two siderophores in low iron organisms. Mycobactin biosynthesis is repressed by IdeR-Fe(2+) complex that binds the IdeR box in ...
Li Liangtao L U of Utah, United - - 2014
Mmt1 and Mmt2 are highly homologous yeast proteins that are the only members of the cation diffusion facilitator transporter family localized to mitochondria. Overexpression of MMT1/2 led to changes in cellular metal homeostasis (increased iron sensitivity, decreased cobalt sensitivity, increased sensitivity to copper), oxidant generation and increased sensitivity to H2O2. ...
Huang Suna S Laboratory of Neuropharmacology and Department of Neurosurgery, South-west Hospital, The Third Military Medical University, Chongqing 400038, - - 2014
The existence of all components of the renin-angiotensin system (RAS) and the iron metabolism system, and the recent findings on the functions of angiotensin II (ANGII) in peripheral iron metabolism imply that ANGII might play a role in iron homeostasis by regulating expression of iron transport proteins in the brain. ...
Foka Pelagia P Laboratory of Molecular Biology and Immunobiotechnology, Department of Biochemistry, Hellenic Pasteur Institute, Athens, - - 2014
Hepatitis C virus (HCV) infection is associated with hepatic iron overload and elevated serum iron that correlate to poor antiviral responses. Hepcidin (HAMP), a 25-aa cysteine-rich liver-specific peptide, controls iron homeostasis. Its expression is up-regulated in inflammation and iron excess. HCV-mediated hepcidin regulation remains controversial. Chronic HCV patients possess relatively ...
Sheldon Jessica R JR Department of Microbiology and Immunology, University of Western Ontario, London, ON, - - 2014
Staphylococcus aureus elaborates two citrate-containing siderophores, staphyloferrin A (SA) and staphyloferrin B (SB), that enhance growth under iron-restriction, yet, paradoxically, expression of the TCA cycle citrate synthase, CitZ, is down-regulated during iron starvation. Iron starvation does, however, result in expression of SbnG, recently identified as a novel citrate synthase that ...
Kim Don-Kyu DK 1] National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea. - - 2014
In response to microbial infection, expression of the defensin-like peptide hepcidin (encoded by Hamp) is induced in hepatocytes to decrease iron release from macrophages. To elucidate the mechanism by which Salmonella enterica var. Typhimurium (S. typhimurium), an intramacrophage bacterium, alters host iron metabolism for its own survival, we examined the ...
Kilinc Veli V Public Health Laboratory, 55139, Kurupelit, Trabzon, - - 2014
Histone deacetylase (HDAC) inhibitors, such as trichostatin A (TSA), and iron chelators, including deferoxamine (DFO) and phenanthroline (PHEN), appear to have anticancer effects. We hypothesized that the HDAC inhibitors and iron chelators would be synergistic with their effect on breast cancer cell line MCF7, because the HDAC inhibitors increase glucose-regulated ...
Sonnweber Thomas T Department of Internal Medicine VI, Medical University Innsbruck, , Innsbruck, - - 2014
Hypoxia affects body iron homeostasis; however, the underlying mechanisms are incompletely understood. Using a standardised hypoxia chamber, 23 healthy volunteers were subjected to hypoxic conditions, equivalent to an altitude of 5600 m, for 6 h. Subsequent experiments were performed in C57BL/6 mice, CREB-H knockout mice, primary hepatocytes and HepG2 cells. ...
Chen Li-Hung LH Institute of Food and Agricultural Sciences, University of Florida, - - 2014
The ability of the necrotrophic fungus Alternaria alternata to detoxify reactive oxygen species (ROS) is crucial for pathogenesis to citrus. We report a regulation of siderophore-mediated iron acquisition and ROS resistance by the NADPH oxidase (NOX), the redox activating YAP1 regulator, and the HOG1 MAP kinase. The A. alternata nonribosomal ...
Reyes-Becerril Martha M Centro de Investigaciones Biológicas del Noroeste (CIBNOR), Mar Bermejo 195, Col. Playa Palo de Santa Rita, La Paz, B.C.S. 23090, - - 2014
Ferritin is a major intracellular iron storage protein in higher vertebrates and plays an important role in iron metabolism. In this study, ferritin H subunit was cloned from the larvae of yellow snapper, Lutjanus argentiventris, by rapid amplification of cDNA ends (RACE) following in silico transcriptome analysis. The full-length cDNAs ...
Chung Jacky J From the Division of Hematology, Brigham and Women's Hospital; Division of Hematology-Oncology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts - - 2014
Mitochondrial iron is essential for the biosynthesis of heme and iron-sulfur ([Fe-S]) clusters in mammalian cells. In developing erythrocytes, iron is imported into the mitochondria by MFRN1 (mitoferrin-1, SLC25A37). Although loss of MFRN1 in zebrafish and mice leads to profound anemia, mutant animals showed no overt signs of porphyria, suggesting ...
Bandyopadhyay Sanghamitra S Neurochemistry Laboratory, Department of Psychiatry-Neuroscience, Massachusetts General Hospital (East), Charlestown, MA 02129, United - - 2014
The neurotoxicity of amyloid beta (Aβ), a major cleavage product of the amyloid precursor protein (APP), is enhanced by iron, as found in the amyloid plaques of Alzheimer's disease (AD) patients. By contrast, the long-known neuroprotective activity of APP is evident after α-secretase cleavage of the precursor to release sAPPα, ...
Kuiper Caroline C Centre for Free Radical Research, Department of Pathology and Biomedical Science, University of Otago, Christchurch, P.O. Box 4345, Christchurch 8140, New Zealand. Electronic address: - - 2014
Hypoxia-inducible factor (HIF)-1 drives the transcription of hundreds of genes to support cell survival under conditions of microenvironmental and metabolic stress. HIF-1 is down-regulated by iron-containing 2-oxoglutarate-dependent enzymes that require ascorbate as a cofactor. The HIF hydroxylases control both protein stability and the formation of an active transcription complex and, ...
Romsang Adisak A Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand ; Laboratory of Biotechnology, Chulabhorn Research Institute, Bangkok, - - 2014
IscR is a global transcription regulator responsible for governing various physiological processes during growth and stress responses. The IscR-mediated regulation of the Pseudomonas aeruginosa isc operon, which is involved in iron-sulphur cluster ([Fe-S]) biogenesis, was analysed. The expression of iscR was highly induced through the exposure of the bacteria to ...
Coffey Richard R Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, United States of - - 2014
It is well known that iron overload can result in pancreatic iron deposition, beta-cell destruction, and diabetes in humans. Recent studies in animals have extended the link between iron status and pancreatic function by showing that iron depletion confers protection against beta-cell dysfunction and diabetes. The aim of the present ...
Zhang Zhuzhen Z Laboratory of Nutrition and Metabolism, Center for Nutrition and Health, Department of Nutrition, Institute of Nutrition and Food Safety, School of Public Health, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, Zhejiang, China ; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, - - 2014
The liver is the primary organ for storing iron and plays a central role in the regulation of body iron levels by secretion of the hormone Hamp1. Although many factors modulate Hamp1 expression, their regulatory mechanisms are poorly understood. Here, we used conditional knockout mice for the iron exporter ferroportin1 ...
Mleczko-Sanecka Katarzyna K Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, - - 2014
The hepatic hormone hepcidin is a key regulator of systemic iron metabolism. Its expression is largely regulated by two signaling pathways, the 'iron-regulated' bone morphogenetic protein (BMP) and the inflammatory JAK-STAT pathways. To obtain broader insights into cellular processes that modulate hepcidin transcription and to provide a resource to identify ...
Casanovas Guillem G Department of Pediatric Oncology, Hematology and Immunology, University Hospital of Heidelberg, Heidelberg, Germany ; Molecular Medicine Partnership Unit, Heidelberg, Germany ; European Molecular Biology Laboratory, Heidelberg, - - 2014
Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels. Hepcidin expression is regulated by the BMP6/SMAD and IL6/STAT signaling cascades. Deregulation of either pathway causes iron-related diseases such as hemochromatosis or anemia of ...
Semsey Szabolcs S Center for Models of Life, Niels Bohr Institute, University of Copenhagen, Copenhagen, - - 2014
Expression of the SodA superoxide dismutase (MnSOD) in Escherichia coli is regulated by superoxide concentration through the SoxRS system and also by Fur (Ferric uptake regulator) through a mixed incoherent feed forward loop (FFL) containing the RyhB small regulatory RNA. In this work I theoretically analyze the function of this ...
Jiang Xuan-Zhao XZ Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400715, P. R. - - 2014
A constant ratio of ferritin heavy chain homolog (HCH) and light chain homolog (LCH) subunits seems to be required to compose the ferritin heteropolymer protein in insects. However, the mechanism by which insect LCH genes regulate protein levels remains unclear. We report that alternative promoters and alternative splicing contribute to ...
Gnana-Prakasam Jaya P JP Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, - - 2014
Matriptase-2 (also known as TMPRSS6) is a critical regulator of the iron-regulatory hormone hepcidin in the liver; matriptase-2 cleaves membrane-bound hemojuvelin and consequently alters bone morphogenetic protein (BMP) signaling. Hemojuvelin and hepcidin are expressed in the retina and play a critical role in retinal iron homeostasis. However, no information on ...
Philippot Quentin Q Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Washington University, St. Louis, Missouri, United States of America; Institut National de la Santé Et de la Recherche Medicale Unit 903, University Hospital, Reims, - - 2014
Free iron in lung can cause the generation of reactive oxygen species, an important factor in chronic obstructive pulmonary disease (COPD) pathogenesis. Iron accumulation has been implicated in oxidative stress in other diseases, such as Alzheimer's and Parkinson's diseases, but little is known about iron accumulation in COPD. We sought ...
Menanteau-Ledouble Simon S Clinical Division of Fish Medicine, University of Veterinary Medicine, Veterinärplatz 1, Vienna 1210, - - 2014
Aeromonas salmonicida is an important fish pathogen that produces a wide and varied array of virulence factors. Here we used iron deprivation by addition of the chelator 2'2-dipyridyl to induce the expression of several such virulence factors in three isolates of Aeromonas salmonicida (one avirulent and two virulent). By using ...
Jacques Jean-François JF Département de Biochimie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Quebec, - - 2014
Iron is required for several metabolic functions involved in cellular growth. Although several players involved in iron transport have been identified, the mechanisms by which iron-responsive transcription factors are controlled are still poorly understood. In Schizosaccharomyces pombe, the Fep1 transcription factor represses genes involved in iron acquisition in response to ...
Worthen Christal A CA Department of Cell and Developmental Biology, Oregon Health and Science University Portland, OR, - - 2014
Fine-tuning of body iron is required to prevent diseases such as iron-overload and anemia. The putative iron sensor, transferrin receptor 2 (TfR2), is expressed in the liver and mutations in this protein result in the iron-overload disease Type III hereditary hemochromatosis (HH). With the loss of functional TfR2, the liver ...
Core Amanda B AB Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Program in Anemia Signaling Research Boston, MA, - - 2014
Mutations in hemojuvelin (HJV) are the most common cause of the juvenile-onset form of the iron overload disorder hereditary hemochromatosis. The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling molecules helped to identify this signaling pathway as a central regulator of the ...
Poli Maura M Molecular Biology Laboratory, Department of Molecular and Translational Medicine, University of Brescia Brescia, - - 2014
The discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by furin into the mature active peptide. Hepcidin binds ferroportin, the only cellular iron exporter, causing the internalization and degradation of both. Thus ...
Zhang De-Liang DL Molecular Medicine Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health Bethesda, MD, - - 2014
Iron regulatory proteins (IRPs) regulate the expression of genes involved in iron metabolism by binding to RNA stem-loop structures known as iron responsive elements (IREs) in target mRNAs. IRP binding inhibits the translation of mRNAs that contain an IRE in the 5'untranslated region of the transcripts, and increases the stability ...
Hamod Mohammed A - - 2014
The outer membrane protein K, OmpK first identified in Vibrio parahaemolyticus has been shown to be a receptor for a broad host range vibriophage KVP40 infecting members of the Vibrionaceae. In the study, the effect of culture conditions on the expression of ompK in V. anguillarum was studied using real-time ...
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