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Cohen Jonathan E JE Section on Nervous System Development and Plasticity, The Eunice Kennedy Shriver National Institute of Child and Human Development, National Institute of Health, Building 35, Room 2A211, Bethesda, MD 20892-3714, - - 2014
Ongoing neuronal activity during development and plasticity acts to refine synaptic connections and contributes to the induction of plasticity and ultimately long-term memory storage. Activity-dependent, post-transcriptional control of mRNAs occurs through transport to axonal and dendritic compartments, local translation and mRNA stability. We have identified a mechanism that contributes to ...
Smalheiser Neil R NR Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA - - 2014
If mRNAs were the only RNAs made by a neuron, there would be a simple mapping of mRNAs to proteins. However, microRNAs and other non-coding RNAs (ncRNAs; endo-siRNAs, piRNAs, BC1, BC200, antisense and long ncRNAs, repeat-related transcripts, etc.) regulate mRNAs via effects on protein translation as well as transcriptional and ...
Wang Chih-Yen CY Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, - - 2014
Astrogliosis occurs at the lesion site within days to weeks after spinal cord injury (SCI) and involves the proliferation and hypertrophy of astrocytes, leading to glia scar formation. Changes in gene expression by deregulated microRNAs (miRNAs) are involved in the process of central nervous system neurodegeneration. Here, we report that ...
Desclaux Mathieu M Biotechnology and Biotherapy, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epiniere, Centre National de la Recherche Scientifique (CNRS) UMR 7225, Institut National de la Santé et de la Recherche Médicale (INSERM) UMRS 975, Université Pierre et Marie Curie (UPMC), Hôpital de la Pitié Salpêtrière, Paris, France; Columbia University, Department of Pathology and Cell Biology Project A.L.S.-Jenifer Estess Laboratory for Stem Cell Research, New York, New - - 2014
In spinal cord injury (SCI), absence of functional recovery and lack of spontaneous axonal regeneration are attributed, among other factors, to the formation of a glial scar that forms both physical and chemical barriers. The glial scar is composed mainly of reactive astrocytes that overexpress two intermediate filament proteins, glial ...
Hoyng Stefan A SA Department of Neuroregeneration, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA Amsterdam, The Netherlands; Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The - - 2014
The clinical outcome of microsurgical repair of an injured peripheral nerve with an autograft is suboptimal. A key question addressed here is: can axon regeneration through an autograft be further improved? In this article the impact of six neurotrophic factors (BDNF, CNTF, GDNF, NGF, NT3 or VEGF) on axon regeneration ...
Salta Evgenia E VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics and Leuven Institute for Neurodegenerative Disorders, KU Leuven, 3000 Leuven, - - 2014
Radial glial progenitors play pivotal roles in the development and patterning of the spinal cord, and their fate is controlled by Notch signaling. How Notch is shaped to regulate their crucial transition from expansion toward differentiation remains, however, unknown. miR-132 in the developing zebrafish dampens Notch signaling via a cascade involving the ...
He Yan Y National Drug Clinical Trial Institution, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037; College of Traditional Chinese Medicine, Southern Medical University, Guangdong Guangzhou, 510515, P.R. - - 2014
N-methyl-d-aspartate (NMDA) receptor subunit GluN1 and GluN2B in hippocampal play key roles in anxiety. Our previous studies show that rhynchophylline, an active component of the Uncaria species, down-regulates GluN2B expression in the hippocampal CA1 area of amphetamine-induced rat. The effects of rhynchophylline on expressions of GluN1 and GluN2B in primary ...
Nielsen Soren S Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne, NE2 4AX, - - 2014
Arimbasseri et al., in their Comment, suggest that to terminate transcription in vivo, RNA polymerase III uses a mechanism other than hairpin-dependent termination and that properties of purified polymerase may depend on preparation procedure. Evidence suggests that our preparation is indeed different from that of other methods. Our new data ...
García-Pérez Daniel D Group of Molecular and Cellular Pharmacology, Medical Faculty of Murcia, Campus de Espinardo, 30100 Murcia, Spain; Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain. Electronic address: - - 2014
Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and pleiotrophin transcription. We observed that single morphine injection and chronic ...
Taniguchi Hiroaki H Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, - - 2014
Disruptions in chromatin regulator genes are frequently the cause of neurodevelopmental and neuropsychiatric disorders. Chromatin regulators are widely expressed in the brain, yet symptoms suggest that specific circuits can be preferentially altered when they are mutated. Using Drosophila allows targeted manipulation of chromatin regulators in defined neuronal classes, lineages, or ...
Zhang Haiyan H Department of Immunology, Medical College of Nantong University, Nantong, 226001, Jiangsu Province, People's Republic of - - 2014
Adenylate cyclase-associated protein 1 (CAP1), a member of cyclase-associated proteins involved in the regulation of actin filaments, was recently reported to play a role in the pathology of sciatic nerves injury. However, the distribution and function of CAP1 in the central nervous system (CNS) remain unclear. To investigate whether CAP1 ...
Greaves Erin E MRC Centre for Reproductive Health, The University of Edinburgh, Queens Medical Research Institute, 47 Little France Cres, Edinburgh EH16 - - 2014
Endometriosis is an estrogen-dependent neurovascular disorder characterised by growth of endometrial tissue (lesions) outside the uterine cavity. Patients suffer chronic pelvic pain and it has been proposed that co-recruitment of nerves/blood vessels (neuroangiogenesis) into the lesions is fundamental to the development of painful symptoms. We hypothesized that estrogen-dependent regulation of ...
Luo Songjiang S Department of Comprehensive Dentistry, University of Texas Health Science Center, San Antonio, TX, - - 2014
Among sodium channel isoforms, Nav 1.6 is selectively expressed at nodes of Ranvier in both the CNS and PNS. However, non-Nav 1.6 isoforms such as Nav 1.2 are also present at the CNS nodes in early development but gradually diminish later. It has been proposed that myelination is part of ...
Goldie Belinda J BJ School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia Schizophrenia Research Institute, Sydney, Australia Centre for Translational Neuroscience and Mental Health, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, - - 2014
Rapid input-restricted change in gene expression is an important aspect of synaptic plasticity requiring complex mechanisms of post-transcriptional mRNA trafficking and regulation. Small non-coding miRNA are uniquely poised to support these functions by providing a nucleic-acid-based specificity component for universal-sequence-dependent RNA binding complexes. We investigated the subcellular distribution of these ...
Hong Peiwei P West China Developmental & Stem Cell Institute, West China Second University Hospital, Sichuan University, Chengdu, 610041, People's Republic of - - 2014
Reactive astrogliosis after spinal cord injury (SCI) contributes to glial scar formation that impedes axonal regeneration. The mechanisms underlying reactive astrocyte proliferation upon injury remain partially understood. MicroRNAs (miRNAs) function as a major class of post-transcriptional gene expression regulators that participate in many biological processes. However, miRNA function during reactive ...
Wang Chun-Juan CJ Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, - - 2014
Lingo-1 is a negative regulator of myelination. Repairment of demyelinating diseases, such as multiple sclerosis (MS)/experimental autoimmune encephalomyelitis (EAE), requires activation of the myelination program. In this study, we observed the effect of RNA interference on Lingo-1 expression, and the impact of Lingo-1 suppression on functional recovery and myelination/remyelination in ...
Sun Xinxin X Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111; Department of Genetics Program, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, - - 2014
Glutamatergic signaling through N-methyl-D-aspartate receptors (NMDARs) is important for neuronal development and plasticity and is often dysregulated in psychiatric disorders. Mice mutant for the transcription factor Sp4 have reduced levels of NMDAR subunit 1 (NR1) protein, but not mRNA, and exhibit behavioral and memory deficits (Zhou et al., 2010). In ...
Bai Qing Q University of Pittsburgh, United - - 2014
Zebrafish CNS axons regenerate robustly following injury; it is thought that CNS oligodendrocytes contribute to this response by expressing growth-promoting molecules. We characterized the mpz gene, which encodes myelin P0 and is upregulated in oligodendroglia following axonal injury. The 2.5kb mpz mRNA is expressed from a single TATA-box promoter. Four ...
Ettle Benjamin B Department of Molecular Neurology, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, - - 2014
Myelin loss is a widespread neuropathological hallmark of the atypical parkinsonian disorder multiple system atrophy (MSA). On a cellular level, MSA is characterized by alpha-synuclein (aSyn)-positive glial cytoplasmatic inclusions (GCIs) within mature oligodendrocytes leading to demyelination as well as axonal and neuronal loss. Oligodendrocyte progenitor cells (OPCs) represent a proliferative ...
Bicker Silvia S Biochemical-Pharmacological Center (BPC) Marburg, Institute of Physiological Chemistry, Philipps-University Marburg, Marburg, - - 2014
Dendritic mRNA transport and local translation in the postsynaptic compartment play an important role in synaptic plasticity, learning and memory. Local protein synthesis at the synapse has to be precisely orchestrated by a plethora of factors including RNA binding proteins as well as microRNAs, an extensive class of small non-coding ...
Hepp Régine R Sorbonne Universités, UPMC Univ Paris 06, UM CR 18, Neuroscience Paris Seine, 75005, Paris, - - 2014
Recent reports point to critical roles of glutamate receptor subunit delta2 (GluD2) at excitatory synapses and link GluD1 gene alteration to schizophrenia but the expression patterns of these subunits in the brain remain almost uncharacterized. We examined the distribution of GluD1-2 mRNAs and proteins in the adult rodent brain, focusing ...
Buffington Shelly A SA Department of Neuroscience, Memory and Brain Research Center, Baylor College of Medicine, Houston, Texas 77030; email: shelly.buffington@bcm.edu , wei.huang@bcm.edu , - - 2014
Activity-dependent changes in the strength of synaptic connections are fundamental to the formation and maintenance of memory. The mechanisms underlying persistent changes in synaptic strength in the hippocampus, specifically long-term potentiation and depression, depend on new protein synthesis. Such changes are thought to be orchestrated by engaging the signaling pathways ...
Heraud-Farlow Jacki E JE Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, 1030 Vienna, - - 2014
Staufen (Stau) proteins belong to a family of RNA-binding proteins (RBPs) that are important for RNA localisation in many organisms. In this review we discuss recent findings on the conserved role played by Stau during both the early differentiation of neurons and in the synaptic plasticity of mature neurons. Recent ...
Chen Hong-Ru HR Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan 11221, Republic of - - 2014
Cdk12 and Cdk13 are Cdc2-related proteins that share 92% identity in their kinase domains. Using in situ hybridization and Western blot analysis, we detected the expression of Cdk12 and Cdk13 mRNAs and their proteins in developing mouse embryos, especially during development of the nervous system. We explored the roles of ...
Sun Tingting T Institute of Neuroscience and Anatomy, Zhejiang University School of Medicine, Hangzhou, - - 2014
Semaphorin3A (sema3a), mainly localized in the olfactory neuron layer and periglomerular layer, is essential for the normal arrangement of axons in the olfactory bulb both in embryonic and adult mice functioning through its dynamic spatiotemporal expression. The regulators that can modulate the expression of sema3a by direct interaction, however, are ...
Park Keun Woo KW Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio - - 2014
The present study investigates the endogenous expression of Suppressor of Cytokine Signaling-3 (SOCS3) after spinal cord injury (SCI) and its effect on SCI-induced cell death in vivo. In addition, we determined whether a reduction of SOCS3 expression induced by microinjection of short hairpin RNA (shSOCS3) carried by lentivirus into spinal ...
Yang Shudong S From the *Department of Pathology and †Central Laboratory, Wuxi People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, People's Republic of - - 2014
Amyloid-β (Aβ) protein and its precursor, amyloid-β precursor protein (β-APP), have traditionally been used in the diagnosis of Alzheimer disease. Their use in diagnosis of traumatic brain injury by forensic analysis is becoming more widespread. However, to date, no reliable small animal model exists to evaluate these brain injury indicators. ...
Li Xiaosu X Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China 072023029@fudan.edu.cn - - 2014
Progenitor cells are segregated into multiple domains along the dorsoventral axis of the vertebrate neural tube, and each progenitor domain generates particular types of neurons. Selective cross-repressive interactions between pairs of class I and class II transcription factors play important roles in patterning neural progenitors into domains with clear boundaries. ...
Dai Zhong-Min ZM Institute of Developmental and Regenerative Biology, Key Laboratory of Organ Development and Regeneration of Zhejiang Province, College of Life Sciences, Hangzhou Normal University, Hangzhou, 310029, People's Republic of - - 2014
Oligodendrocytes are myelin-forming glia that ensheath the axons of neurons in the CNS. Recent studies have revealed that Wnt/β-catenin signaling plays important roles in oligodendrocyte development and myelin formation. However, there are conflicting reports on the specific function of Wnt signaling components in oligodendrocyte specification and differentiation. In the present ...
Gardiol Alejandra A The Wellcome CRUK Gurdon Institute, University of Cambridge, Tennis Court Road Cambridge CB2 1QN, United - - 2014
The post-synaptic translation of localised mRNAs has been postulated to underlie several forms of plasticity at vertebrate synapses, but the mechanisms that target mRNAs to these postsynaptic sites are not well understood. Here we show that the evolutionary conserved dsRNA binding protein, Staufen, localises to the postsynaptic side of the ...
Szostak Natalia N Institute of Computing Science; Poznan University of Technology; Poznan, - - 2014
Intercellular communication mediated by extracellular vesicles has proved to play an important role in normal and pathological scenarios. However not too much information about the sorting mechanisms involved in loading the vesicles is available. Recently, our group has characterized the mRNA content of vesicles released by hepatic cellular systems, showing ...
Yamazaki Reiji R Department of Molecular Neurobiology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, - - 2014
Myelin is a dynamic multilamellar structure that ensheathes axons and is crucial for normal neuronal function. In the central nervous system (CNS), myelin is produced by oligodendrocytes that wrap many layers of plasma membrane around axons. The dynamic membrane trafficking system, which relies on motor proteins, is required for myelin ...
Palazuelos Javier J Department of Pharmacological Sciences, Center for Molecular Medicine - - 2014
Research on myelination has focused on identifying molecules capable of inducing oligodendrocyte (OL) differentiation in an effort to develop strategies that promote functional myelin regeneration in demyelinating disorders. Here, we show that transforming growth factor β (TGFβ) signaling is crucial for allowing oligodendrocyte progenitor (OP) cell cycle withdrawal, and therefore, ...
Kesherwani Varun V Division of Neurosurgery, Department of Surgery, University of Nebraska Medical Center, Omaha, NE - - 2014
Fasudil (HA-1077), a specific Rho kinase II (ROCKII) inhibitor, is in clinical trials for recovery from spinal cord injury (SCI). The primary role of Fasudil is in axonal regeneration, as it inhibits ROCKII, the key signaling molecule involved in collapse of axon growth cone. Astrogliosis, due to the activation of ...
Wang Yazhou Y Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. - - 2014
Trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, has been shown to have neuroprotective, neurotrophic and anti-inflammatory properties in both animal and cellular models of neurodegenerative disorders. In a previous study of ours, we demonstrated that TSA inhibited the proliferation and increased the differentiation of neuronal precursor cells (NPCs). However, the effects of ...
Liu Yang Y Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People's Republic of - - 2014
Ebp1, an ErbB3-binding protein, is the human homologue of the cell cycle-regulated mouse protein p38-2G4. Ebp1 was reported to inhibit the proliferation and induce the differentiation of human cancer cells. Its p48 isoform contributes to neuronal differentiation and growth factor specificity. However, the expression and role of Ebp1 in peripheral ...
Cooney Sean J - - 2014
Abstract Reactive oxygen species and the NADPH oxidase (NOX) enzyme are both up-regulated after spinal cord injury (SCI) and play significant roles in promoting post-injury inflammation. However, the cellular and temporal expression profile of NOX isotypes, including NOX2, 3 and 4, after SCI is currently unclear. The purpose of this ...
Cheng Albert W AW Whitehead Institute of Biomedical Research, Cambridge, MA, United - - 2014
The scope and roles of regulated isoform gene expression during erythroid terminal development are poorly understood. We identified hundreds of differentiation-associated isoform changes during terminal erythropoiesis. Sequences surrounding cassette exons of skipped exon (SE) events are enriched for motifs bound by the Muscleblind-like family of splicing factors. Knockdown of Mbnl1 ...
Lee-Liu Dasfne - - 2014
Xenopus laevis has regenerative and non-regenerative stages. As a tadpole, it is fully capable of functional recovery after a spinal cord injury, while its juvenile form (froglet) loses this capability during metamorphosis. We envision that comparative studies between regenerative and non-regenerative stages in Xenopus could aid in understanding why spinal ...
Wilkerson Julia R JR Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, - - 2014
Experience refines synaptic connectivity through neural activity-dependent regulation of transcription factors. Although activity-dependent regulation of transcription factors has been well described, it is unknown whether synaptic activity and local, dendritic regulation of the induced transcripts are necessary for mammalian synaptic plasticity in response to transcription factor activation. Neuronal depolarization activates ...
Salles Angeles A Laboratorio de Neurobiología de la Memoria, FBMC, FCEyN, UBA, - IFIBYNE, CONICET, 2°piso, pabellón II, Intendente Güiraldez 2160, Ciudad Universitaria, CP 1428, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: - - 2014
Several transcription factors are present at the synapse, and among these are the Rel-NF-kappa B pathway components. NF-kappa B is a constitutive transcription factor, with a strong presence in the brain of which a considerable part is located in the neuropiles. This localization of the transcription factor, plus evidence pointing ...
Volk David W DW Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA; - - 2014
Disturbances in parvalbumin- and somatostatin-containing neurons, including deficits in the gamma-aminobutyric acid (GABA)-synthesizing enzyme GAD67 in the prefrontal cortex (PFC) in schizophrenia, may be related to disrupted pre- and/or postnatal development. Deficits in the transcription factor Lhx6, which regulates parvalbumin and somatostatin neuron development, are associated with GAD67 deficits in ...
Böttner Martina M Institute of Anatomy, Christian-Albrechts-University of Kiel, Kiel, Germany. Electronic address: - - 2014
In the central nervous system (CNS), reelin coordinates migration and lamination of neurons and regulates synaptic plasticity, whereas its role in the enteric nervous system (ENS) remains enigmatic. Thus we determined the expression pattern and localization of reelin in the human ENS and monitored the time course of mRNA expression ...
Weyne Emmanuel E Laboratory for Experimental Urology, Department of Development and Regeneration, University of Leuven, Leuven, - - 2014
Erectile dysfunction (ED) remains a frequent complication of radical prostatectomy due to injury to the cavernous nerves (CNs). A recent microarray showed the neuropeptide galanin to be one of the most strikingly upregulated genes in the rat major pelvic ganglion (MPG) after bilateral CN crush injury (BCNI). The aim of ...
Mairhofer Juergen - - 2014
The phage-derived T7 RNA polymerase is the most prominent orthogonal transcriptions system used in the field of synthetic biology. However, gene expression driven by T7 RNA polymerase is prone to read-through transcription due to contextuality of the T7 terminator. The native T7 terminator has a termination efficiency of approximately 80% ...
Fernando Chathurini C Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia ; - - 2014
During development of the central nervous system trophic, together with genetic, cues dictate the balance between cellular proliferation and differentiation. Subsequent to the birth of new neurons additional intrinsic and extrinsic signals regulate the connectivity of these cells. While a number of regulators of ventral midbrain (VM) neurogenesis and dopaminergic ...
Login Hande H Department of Molecular Biology, Umeå University, 901 87, Umeå, - - 2014
It is well established that environmental influences play a key role in sculpting neuronal connectivity in the brain. One example is the olfactory sensory map of topographic axonal connectivity. While intrinsic odorant receptor signaling in olfactory sensory neurons (OSN) determines anterior-posterior counter gradients of the axonal guidance receptors Neuropilin-1 and ...
Wang Xun X Department of Biological Sciences, College of Biological Sciences and Biotechnology, Chungnam National University, Daejeon 305-764, Republic of - - 2014
The gal operon of Escherichia coli has 4 cistrons, galE, T, K, and M. In our previous report (1), we have identified 6 different mRNA species, mE1, mE2, mT1, mK1, mK2, and mM1in the gal operon and mapped these mRNAs. The mRNA map suggests a gradient of gene expression known ...
Satoh Jun-Ichi - - 2014
Nasu-Hakola disease (NHD) is a rare autosomal recessive disorder characterized by sclerosing leukoencephalopathy and multifocal bone cysts, caused by a loss-of-function mutation of either DAP12 or TREM2. TREM2 and DAP12 constitute a receptor/adaptor signaling complex expressed exclusively on osteoclasts, dendritic cells, macrophages, and microglia. Neuropathologically, NHD exhibits profound loss of ...
Kasabova Mariana M Inserm U1100 / CEPR, - - 2014
Lung matrix homeostasis partly depends on the fine regulation of proteolytic activities. We examined the expression of human cysteine cathepsins (Cats) and their relative contribution to TGF-β1-induced fibroblast differentiation into myofibroblasts. Assays were conducted using both primary fibroblasts obtained from patients with idiopathic pulmonary fibrosis (IPF) and human lung CCD-19Lu ...
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