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Celikbilek Asuman A Department of Neurology, Medical School, Bozok University, 66200, Yozgat, Turkey, - - 2014
Evidence suggests that peripheral nerve injury occurs during the early stages of disease with mild glycemic dysregulation. Two proteins, neuron-specific enolase (NSE) and neurofilament light chain (NFL), have been examined previously as possible markers of neuronal damage in the pathophysiology of neuropathies. Herein, we aimed to determine the potential value ...
Wu-Fienberg Yuewei Y Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, Campus Box 8238, 660 South Euclid Avenue, St. Louis, MO, - - 2014
Glial cell-line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor known to enhance motor nerve regeneration following its delivery. However, recent studies have determined that extended GDNF delivery to regenerating axons can entrap motor axons at the site of GDNF delivery. This entrapment leads to reduced motor axons available to ...
Loya Carlos M CM Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, - - 2014
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play important roles in nervous system development and physiology. However, our understanding of the strategies by which miRNAs control synapse development is limited. We find that the highly conserved miRNA miR-8 regulates the morphology of presynaptic arbors at the Drosophila neuromuscular ...
Yue Ying Y The Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, People's Republic of - - 2014
LIN28, an RNA-binding protein, is known to be involved in the regulation of many cellular processes, such as embryonic stem cell proliferation, cell fate succession, developmental timing, and oncogenesis. However, its expression and function in central nervous system still unclear. In this study, we performed an acute spinal cord contusion ...
Zhou Liang L Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, People's Republic of - - 2014
Oligodendrocytes are generated by the differentiation and maturation of oligodendrocyte precursor cells (OPCs). The failure of OPC differentiation is a major cause of demyelinating diseases; thus, identifying the molecular mechanisms that affect OPC differentiation is critical for understanding the myelination process and repairing after demyelination. Although prevailing evidence shows that ...
Agnese Marisa M Department of Biology, University of Naples Federico II, Naples, - - 2014
Starting from the knowledge that in the reproductive period the Vasoactive Intestinal Peptide (VIP) is widely distributed in Podarcis sicula testis, we studied VIP expression and the localization of the neuropeptide and its receptors in the testis of the Italian wall lizard Podarcis sicula in the other phases of its ...
Lenzken Silvia Carolina SC Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, - - 2014
In mammalian cells in general and in neurons in particular, mRNA maturation, translation, and degradation are highly complex and dynamic processes. RNA-binding proteins (RBPs) play crucial roles in all these events. First, they participate in the choice of pre-mRNA splice sites and in the selection of the polyadenylation sites, determining ...
Farris Shannon S Reeve-Irvine Research Center and Departments of Anatomy and Neurobiology, Neurobiology and Behavior, and Neurosurgery, University of California, Irvine, Irvine, California - - 2014
Arc is an immediate early gene that is unique among neuronal mRNAs because its transcripts are transported into dendrites and accumulate near activated synapses, presumably to be translated locally. These qualities pose Arc as playing an important, yet not fully understood, role in the activity-dependent modifications of synapses that are ...
Bercury Kathryn K KK Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, and Department of Neurology and Neuroscience, New Jersey Medical School Cancer Center, Rutgers Biomedical and Health Sciences, Newark, New Jersey - - 2014
During CNS development, oligodendrocytes, the myelinating glia of the CNS, progress through multiple transitory stages before terminating into fully mature cells. Oligodendrocyte differentiation and myelination is a tightly regulated process requiring extracellular signals to converge to elicit specific translational and transcriptional changes. Our lab has previously shown that the protein ...
Cui Zhiming Z Department of Spine Surgery, The Second Affiliated Hospital of Nantong University, Nantong University, 226001, Nantong, Jiangsu, People's Republic of China, - - 2014
Hypoxia and other adverse conditions are usually encountered by rapidly growing cells. The RNA-binding motif protein 3 (RBM3) is induced by low temperature and hypoxia. However, its expression and function in spinal cord injury are still unclear. To investigate the certain expression and biological function in the central nervous system, ...
Santiago Celine C Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, - - 2014
Transcription factors establish neural diversity and wiring specificity; however, how they orchestrate changes in cell morphology remains poorly understood. The Drosophila Roundabout (Robo) receptors regulate connectivity in the CNS, but how their precise expression domains are established is unknown. Here, we show that the homeodomain transcription factor Hb9 acts upstream ...
Zeng X X Provincial Key Laboratory of Developmental Biology and Neuroscience, Fujian Normal University, Fuzhou, China; Research Institute of Traditional Chinese Medicine, Fuzhou, Fujian, - - 2014
Adrenomedullin (AM) belongs to the calcitonin gene-related peptide (CGRP) family. Our previous studies show that chronic exposure to morphine increases spinal AM bioactivity, contributing to the development and maintenance of morphine tolerance. This study investigated the possible involvement of AM in morphine-evoked gliosis. Real-time polymerase chain reaction was performed to ...
Kitic Maja M Medical University Vienna, Center for Brain Research, Department of Neuroimmunology, Spitalgasse 4, 1090, Vienna, - - 2014
Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase. At these sites, it is important for the generation and maintenance of non-inflammatory, tissue-resident dendritic cell responses. We show here that TSLP is also expressed in the central ...
Daugherty Rebecca L RL Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL - - 2014
α-Catenin (α-cat) is an actin-binding protein required for cell-cell cohesion. Although this adhesive function for α-cat is well appreciated, cells contain a substantial amount of nonjunctional α-cat that may be used for other functions. We show that α-cat is a nuclear protein that can interact with β-catenin (β-cat) and T-cell ...
Wu Kaiyuan - - 2014
Abstract S-nitrosoglutathione reductase (GSNOR) is the key enzyme controlling the intracellular levels of S-nitrosoglutathione and S-nitrosothiols. GSNOR has been implicated in many biological processes, such as the cardiovascular and respiratory systems. However, the role of GSNOR, the sole brain alcohol dehydrogenase, in the nervous systems is still largely a mystery. ...
Laedermann Cédric J - - 2014
Dysregulation of voltage-gated sodium channels (Navs) is believed to play a major role in nerve fiber hyperexcitability associated with neuropathic pain. A complete transcriptional characterization of the different isoforms of Navs under normal and pathological conditions had never been performed on mice, despite their widespread use in pain research. Navs ...
Qu Yang Y Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin 13033, P.R. - - 2014
EphrinB3 may restrict axonal regeneration and recovery following traumatic injury of the adult mammalian central nervous system (CNS). Therefore, inhibition of ephrinB3 expression may enhance the ability of the nervous system to regenerate following damage. In the present study, lentiviral expressing vectors, pGCSIL-GFP, expressing an active small interfering RNA (siRNA) ...
Miyamoto Yuki Y Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo, Tokyo 113-8510, Japan The Japan Human Health Sciences Foundation, Chuo, Tokyo 103-0001, - - 2014
Oligodendrocyte precursor cells differentiate to produce myelin sheaths that insulate axons to ensure fast propagation of action potentials. Many aspects of differentiation are regulated by multiple extracellular signals. However, their intracellular signalings remain elusive. Here, we show that Rab35 and its effector, ACAP2, a GTPase-activating protein that switches off Arf6 ...
Lacin Haluk H Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, - - 2014
Most neurons of the adult Drosophila ventral nerve cord arise from a burst of neurogenesis during the third larval instar stage. Most of this growth occurs in thoracic neuromeres, which contain 25 individually identifiable postembryonic neuronal lineages. Initially, each lineage consists of two hemilineages - 'A' (Notch(On)) and 'B' (Notch(Off)) ...
Xu Jie - - 2014
Bone cancer pain (BCP) is one of the most disabling factors in patients suffering from primary bone cancer or bone metastases. Recent studies show several chemokines (for example, CCL2, CXCL10) in the spinal cord are involved in the pathogenesis of BCP. Here we investigated whether and how spinal CXCL1 contributes ...
Chiaretti A - - 2014
Neurotrophic factors, such as Nerve Growth Factor (NGF), play a key role in the stimulation of sprouting, synaptic plasticity, and reorganization after spinal cord damage. The aim of this study was to investigate the expression of nerve growth factor (NGF) in the cerebrospinal fluid (CSF) of newborns with myelomeningocele (MMC) ...
Nakamura Yasuhiro Y Department of Pathology, Tohoku University Graduate School of Medicine, Sendai 980- 8575, - - 2014
The majority of the cases diagnosed as primary aldosteronism (PA) are caused by aldosterone-producing adenoma (APA) or idiopathic hyperaldosteronism (IHA). Histopathologically, both IHA and adjacent adrenal glands of APA demonstrate remodeled subcapsular zone (RSZ) but these zones in two disorders are markedly different in terms of steroidogenesis. 3β-hydroxysteroid dehydrogenase/Δ(5)-Δ(4) isomerase ...
Tsutsumi Kuniaki K Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: - - 2014
Oxaliplatin causes severe peripheral neuropathy. In this study, we examined hypomyelination in the peripheral nerve in oxaliplatin-induced neuropathy rat model. Gene expression of neuregulin 1 (NRG1), a myelination regulatory factor, is reduced in the dorsal root ganglion (DRG) in DNA microarray analysis. Oxaliplatin increased the g-ratio and reduced levels of ...
Raddant Ann C AC Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, - - 2014
To examine calcitonin gene-related peptide (CGRP) gene expression under inflammatory conditions using trigeminal ganglia organ cultures as an experimental system. These cultures have increased proinflammatory signaling that may mimic neurogenic inflammation in the migraine state. The trigeminal nerve sends peripheral pain signals to the central nervous system during migraine. Understanding ...
Lerch Jessica K JK Department of Neuroscience, Center for Brain and Spinal Cord Repair, The Ohio State University, 460W 12th Ave, Columbus, OH 43210, USA; The Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, 1400 NW 12th Ave, Miami, FL 33136, - - 2014
A number of genes regulate regeneration of peripheral axons, but their ability to drive axon growth and regeneration in the central nervous system (CNS) remains largely untested. To address this question we overexpressed eight transcription factors and one small GTPase alone and in pairwise combinations to test whether combinatorial overexpression ...
Hao Ning N Department of Anatomy and Neurobiology, the Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, - - 2014
Corticospinal tract is mainly descending tracts by dominating voluntary movement of the limbs and fine movement of distal limb, especially in mammals. Distal axonal degeneration is called anterograde degeneration. Proximal end is connected to the neuron cell body, whereas retrograde degeneration is very slight with the possibility of regeneration. MicroRNAs ...
Zhu Qiang Q Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40292, - - 2014
In the central nervous system (CNS), oligodendrocyte maturation and axonal myelination occur on a predictable schedule, but the underlying timing mechanisms are largely unknown. In the present study, we demonstrate that Nkx2.2 homeodomain transcription factor is a key regulator for the timing of oligodendrocyte differentiation during development. Whereas induced expression ...
Tchetchelnitski Viktoria V Institute of Child Health, University College London, 30 Guilford Street, London WC1N - - 2014
Receptor-type protein tyrosine phosphatases (RPTPs) have been implicated as direct or indirect regulators of neurotrophin receptors (Trks). It remains less clear if and how such RPTPs might regulate Trk proteins in vivo during development. Here we present a comparative expression profile of RPTP genes and Trk genes during early stages ...
Ichii Osamu O Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan. Electronic address: - - 2014
MicroRNAs (miRNAs) play a role in the pathogenesis of certain diseases and may serve as biomarkers. Here, we present the first analysis of miRNA expression in the kidneys of healthy cats and dogs. Kidneys were divided into renal cortex (CO) and medulla (MD), and RNA sequence analysis was performed using ...
Zavala K K Department of Anesthesia and Perioperative Care Division of Pain Medicine University of California, San Francisco - - 2014
Activation of peripheral nociceptors by products of inflammation has been shown to be dependent on specific sensory transducing elements such as the capsaicin receptor, TRPV1. The development of high-affinity antagonists to TRPV1 as well as to other receptors capable of detecting noxious stimuli has now become a major focus in ...
Zhang J J Medical College, Shandong University, Jinan, Shandong, - - 2014
Decades of research have provided the data to confirm the hypothesis that there is bidirectional communication between the central nervous system and the immune system in psoriasis pathogenesis, but the contribution of the cutaneous neural system remains underexplored. In this study, we evaluated the molecular mechanisms by which nerve growth ...
Lee Dongwook D University of California San Diego, La Jolla, Calfornia, 92037, United - - 2014
To test whether a diet supplemented with coenzyme Q10 (CoQ10) ameliorates glutamate excitotoxicity- and oxidative stress-mediated retinal ganglion cell (RGC) degeneration by preventing mitochondrial alterations in the retina of glaucomatous DBA/2J mice. Pre-glaucomatous DBA/2J and age-matched control DBA/2J-Gpnmb+ mice were fed with CoQ10 (1%) or a control diet daily for ...
Sugimoto Tatsuhiko T Department of Pharmacology, Hiroshima University Graduate School of Biomedical & Health Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553, - - 2014
It has been previously reported that spinal clock genes controlled under circadian rhythm contribute to the regulation of astrocytic function, which in turn is involved in diverse processes such as nociceptive transduction and the induction of inflammation. However, how clock genes expressed in spinal cord astrocytes are associated with the ...
Ishtiaq Muhammad M Molecular Medicine Research Group, Robarts Research Institute, Western University, London, Ontario, - - 2014
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motor neuron degeneration and neurofilament aggregate formation. Spinal motor neurons in ALS also show a selective suppression in the levels of low molecular weight neurofilament (NEFL) mRNA. We have been interested in investigating the role of microRNAs (miRNAs) in ...
Goldshmit Yona Y Australian Regenerative Medicine Institute East Melbourne, VIC, Australia ; Centre for Eye Research Australia & Royal Victorian Eye and Ear Hospital East Melbourne, VIC, - - 2014
A major impediment for recovery after mammalian spinal cord injury (SCI) is the glial scar formed by proliferating reactive astrocytes. Finding factors that may reduce glial scarring, increase neuronal survival, and promote neurite outgrowth are of major importance for improving the outcome after SCI. Exogenous fibroblast growth factor (Fgf) has ...
Gojska Nicole M NM Departments of Physiology, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada M5S - - 2014
A novel RFamide peptide, gonadotropin-inhibitory hormone (GnIH) has emerged as a modulator of avian reproduction. However, the functional role of the mammalian homologue, RFRP-3 remains poorly understood. The RFRP-3 neuronal circuit is influenced by the stress axis. However, whether the Rfrp gene is under direct glucocorticoid (GC)-mediated transcriptional regulation, in ...
Xu Dawei D Department of Orthopedics, The Second Affiliated Hospital of Nantong University, Nantong, 226001, People's Republic of - - 2014
Wnt can induce signal transduction via the canonical pathway, which was involved in many processes in the nervous system. Nemo-like kinase (NLK) acts as a negative regulator of β-catenin/T-cell factor/lymphoid enhancer factor (LEF) and functions downstream of transforming growth factor β-activated kinase-1 in the Wnt signaling pathway. In this study, ...
Hancock Melissa L ML Department of Cell Biology, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts - - 2014
Developing axons can locally synthesize proteins, with roles in axon growth, guidance, and regeneration, but the mechanisms that regulate axonal mRNA translation are not well understood. MicroRNAs (miRNAs) are important regulators of translation but have still been little characterized in developing axons. Here we study mouse dorsal root ganglion (DRG) ...
Smalheiser Neil R NR Department of Psychiatry and Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois, United States of - - 2014
Because of the role played by miRNAs in post-transcriptional regulation of an array of genes, their impact in neuropsychiatric disease pathophysiology has increasingly been evident. In the present study, we assessed microRNA expression in prefrontal cortex (Brodmann area 10) of a well-characterized cohort of major depressed, bipolar, and schizophrenia subjects ...
Balasanyan Varuzhan V Department of Biology, Program in Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States of - - 2014
The localization of mRNAs within axons and dendrites allows neurons to manipulate protein levels in a time and location dependent manner and is essential for processes such as synaptic plasticity and axon guidance. However, an essential step in the process of mRNA localization, the decision to traffic to dendrites and/or ...
Huang Yan Y Department of Anesthesiology, School of Medicine, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200011, China. - - 2014
Recent studies have shown that dexmedetomidine exerts an anti-inflammatory effect by reducing serum levels of inflammatory factors, however, the up-stream mechanism is still unknown. The transcription factor NF-κB enters the nucleus and promotes the transcription of its target genes, including those encoding the pro-inflammatory cytokines IL-6 and TNF-α. In this ...
Codeluppi Simone S Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, - - 2014
After contusion spinal cord injury (SCI), astrocytes become reactive and form a glial scar. While this reduces spreading of the damage by containing the area of injury, it inhibits regeneration. One strategy to improve the recovery after SCI is therefore to reduce the inhibitory effect of the scar, once the ...
Neumann Carolin C Department of Anatomy II, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, - - 2014
The aqueous humor (AH) component transforming growth factor (TGF)-β2 is strongly correlated to primary open-angle glaucoma (POAG), and was shown to up-regulate glaucoma-associated extracellular matrix (ECM) components, members of the ECM degradation system and heat shock proteins (HSP) in primary ocular cells. Here we present osteopontin (OPN) as a new ...
Wilson Ariel M AM Department of Neuroscience and Groupe de Recherche sur le Système Nerveux Central, University of Montreal Hospital Research Center (CR-CHUM), University of Montreal, Montreal, Quebec, - - 2014
The transcription factor p53 mediates the apoptosis of post-mitotic neurons exposed to a wide range of stress stimuli. The apoptotic activity of p53 is tightly regulated by the apoptosis-stimulating proteins of p53 (ASPP) family members: ASPP1, ASPP2 and iASPP. We previously showed that the pro-apoptotic members ASPP1 and ASPP2 contribute ...
Yin H L HL Department of Neurology, The 148th Hospital, Zibo, Shandong, - - 2014
Curcumin has been widely used for the prevention and treatment of Alzheimer's disease (AD), but its mechanism is still not clear. Inhibitory factors of axonal regeneration have been shown to cause a series of pathophysiological changes in the early period of AD. In this study, the co-receptor (Nogo receptor; NgR) ...
Luo Jian-Gang JG Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, - - 2013
Objective. It is known that noxious stimuli from inflamed tissues may increase the excitability of spinal dorsal horn neurons (central sensitization), which can signal back and contribute to peripheral inflammation. However, the underlying mechanisms have yet to be fully defined. A number of recent studies indicate that spinal nuclear factor-kappaB ...
Zhu Xiaojian X Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China; Department of Orthopaedics, Affiliated Mental Health Center of Nantong University, Nantong 226001, People's Republic of - - 2013
K-homology splicing regulator protein (KHSRP), a multifunctional RNA-binding protein, was originally thought to primarily control mRNA decay. KHSRP was shown to be involved in p38MAPK, NF-κB and the JAK2-STAT-1a pathways. Besides, KHSRP regulated neuronal localization of beta-actin and microtubule-associated protein 2 (MAP2) mRNAs, respectively. However, the expression and roles of ...
Lindblom Rickard P F RP Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, - - 2013
The complement system is activated in a wide spectrum of CNS diseases and is suggested to play a role in degenerative phenomena such as elimination of synaptic terminals. Still, little is known of mechanisms regulating complement activation in the CNS. Loss of synaptic terminals in the spinal cord after an ...
Garza-Manero Sylvia S Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria. CP 014510, México, DF. Electronic address: - - 2013
MicroRNAs (miRNAs) are small non-coding RNAs that control a wide range of functions in the cell. They act as post-transcriptional gene regulators throughout development and in adulthood, although recent evidence suggests also their potential role in the onset and development of various diseases and neuropathologies. In neurons miRNAs seem to ...
Gill L C LC University of Florida, College of Public Health and Health Professions, McKnight Brain Institute, Department of Physical Therapy, PO Box 100154, 100 S. Newell Drive, Gainesville, FL - - 2013
A cervical (C2) hemilesion (C2Hx), which disrupts ipsilateral bulbospinal inputs to the phrenic nucleus, was used to study diaphragm plasticity after acute spinal cord injury. We hypothesized that C2Hx would result in rapid atrophy of the ipsilateral hemidiaphragm and increases in mRNA expression of proteolytic biomarkers. Diaphragm tissue was harvested ...
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