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Liu Xuehui X State Key Laboratory of Cardiovascular Disease, Division of Population Genetics, Fuwai Hospital & National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College & National Human Genome Center at Beijing, Beijing, - - 2014
-Hyperhomocysteinemia is a risk factor for cardiovascular disease. Coactivator- associated arginine methyltransferase 1 (CARM1) participates in the synthesis of homocysteine, but whether the genetic variations regulate CARM1 expression and homocysteine levels remains unknown. -Functional analyses combined with an association study were conducted to identify the causal variant for CARM1 expression ...
Faso Daniel J DJ School of Behavioral and Brain Sciences, The University of Texas at Dallas, GR41, Richardson, TX, 75080, - - 2014
Though many studies have examined facial affect perception by individuals with autism spectrum disorder (ASD), little research has investigated how facial expressivity in ASD is perceived by others. Here, naïve female observers (n = 38) judged the intensity, naturalness and emotional category of expressions produced by adults with ASD (n = 6) and typically ...
van Loosdregt Jorg J Division of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Cell Biology, University Medical Center Utrecht, Utrecht, The - - 2014
Forkhead box (FOX)P3 is a requisite transcription factor for the development and maintenance of immunosuppressive function of regulatory T (Treg) cells, and therefore for immune homeostasis. Post-translational modifications (PTMs) can transiently alter the functionality of transcription factors, and recent evidence reveals that FOXP3 can be regulated by various PTMs including ...
Fukazawa Jutarou J Department of Biological Science, Graduate School of Science, Hiroshima University, Kagamiyama, Higashi-Hiroshima 739-8526, Japan RIKEN Plant Science Center, Tsurumi, Yokohama, Kanagawa 230-0045, Japan Department of Biological Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan - - 2014
Gibberellins (GAs) are essential regulators of plant development, and DELLAs are negative regulators of GA signaling. The mechanism of GA-dependent transcription has been explained by DELLA-mediated titration of transcriptional activators and their release through the degradation of DELLAs in response to GA. However, the effect of GA on genome-wide expression ...
Zhang Yang Y Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, - - 2014
SIMPL (Signaling Molecule that associates with the mouse Pelle-Like Kinase) has been recently identified as a co-regulator of NF-κB dependent transcription. Here, we report the discovery and functional analysis of the SIMPL in a mollusk, Crassostrea gigas, which terms as CgSIMPL. CgSIMPL is comprised of 252 amino acids and shares ...
Du Chen C National Institutes of Health, United - - 2014
Increasing evidence indicates that transcription and alternative splicing are coordinated processes; however, our knowledge of specific factors implicated in both functions during the process of adipocyte differentiation is limited. We have previously demonstrated that the zinc finger protein ZNF638 plays a role as a transcriptional coregulator of adipocyte differentiation via ...
Narkpuk Jaraspim J Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Phaholyothin Rd, Klong 1, Klong Luang, Pathumthani 12120, - - 2014
While viral inhibition by tethering of budding virions to host cell membranes has been focused upon as one of the main functions of BST-2/tetherin, BST-2 is thought to possess other functions as well. Overexpression of BST-2 was found here to down-regulate transient protein expression. Removal of the N- and C-terminal ...
Mei Chao C MOE Systems Biology and Bioinformatics Laboratory, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, - - 2014
A dominant suppressor of the ABAR overexpressor, soar1-1D, from CHLH/ABAR [coding for Mg-chelatase H subunit/putative abscisic acid (ABA) receptor (ABAR)] overexpression lines was screened to explore the mechanism of the ABAR-mediated ABA signalling. The SOAR1 gene encodes a pentatricopeptide repeat (PPR) protein which localizes to both the cytosol and nucleus. ...
Keung Albert J AJ Department of Biomedical Engineering and Center of Synthetic Biology, Boston University, Boston, MA 02215, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, - - 2014
The transcription of genomic information in eukaryotes is regulated in large part by chromatin. How a diverse array of chromatin regulator (CR) proteins with different functions and genomic localization patterns coordinates chromatin activity to control transcription remains unclear. Here, we take a synthetic biology approach to decipher the complexity of ...
Fourquin Chloé C Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia, - - 2014
CRABS CLAW (CRC) is a member of the YABBY family of transcription factors involved in carpel morphogenesis, floral determinacy and nectary specification in arabidopsis. CRC orthologues have been functionally characterized across angiosperms, revealing additional roles in leaf vascular development and carpel identity specification in Poaceae. These studies support an ancestral ...
Schmidt Susanne S Centre de Recherche en Biochimie Macromoléculaire; CNRS - UMR 5237; Universités Montpellier I et II; Montpellier - - 2014
Rho GTPases oscillate between an inactive GDP-bound state and an active GTP-bound state. They are activated by Rho Guanine nucleotide Exchange Factors (GEF), which accelerate the GDP to GTP exchange. RhoGEFs fall into two different classes: the Dbl family and the DOCK family of proteins. In this review, we focus ...
Mahato Simpla S Department of Biology, Indiana University, Bloomington, Indiana, United States of - - 2014
A hallmark of visual rhabdomeric photoreceptors is the expression of a rhabdomeric opsin and uniquely associated phototransduction molecules, which are incorporated into a specialized expanded apical membrane, the rhabdomere. Given the extensive utilization of rhabdomeric photoreceptors in the eyes of protostomes, here we address whether a common transcriptional mechanism exists ...
Perales Roberto R Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of - - 2014
During C. elegans development, microRNAs (miRNAs) function as molecular switches that define temporal gene expression and cell lineage patterns in a dosage-dependent manner. It is critical, therefore, that the expression of miRNAs be tightly regulated so that target mRNA expression is properly controlled. The molecular mechanisms that function to optimize ...
Espinosa L L Stem Cells and Cancer Research Laboratory, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, - - 2014
NF-κB pathway exerts an essential function in the regulation of the immune response, which has been the nucleus of numerous studies for the past 25 years. Both activation of the pathway and termination of the NF-κB response are tightly regulated events, which is essential to prevent exacerbated inflammatory responses. Thus, ...
Zhang Rui R Department of Colorectal Surgery, Liaoning Cancer Hospital & Institute, Shenyang, - - 2014
Background/Aims: To identify the regulator of nucleotide-binding oligomerization domain-containing protein 1 (NOD1) and its regulatory function. Methods and Results : We performed a yeast two-hybrid screening assay and identified the E3 ligase RNF34 as a candidate partner of NOD1. Using co-immunoprecipitation (co-IP) and glutathione S transferase (GST)-pull down assays, we ...
Bowers Erin E Department of Plant Pathology and Microbiology, Iowa State University , 160 Seed Science Building, Ames, Iowa 50011, United - - 2014
Field trials were conducted from 2007 to 2010 to compare grain fumonisin levels among non-Bt maize hybrids and Bt hybrids with transgenic protection against manual infestations of European corn borer (ECB) and Western bean cutworm (WBC). HPLC and ELISA were used to measure fumonisin levels. Results of the methods were ...
Garner Ashley L AL Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, - - 2014
Although the basic mechanisms of prokaryotic transcription are conserved, it has become evident that some bacteria require additional factors to allow for efficient gene transcription. CarD is an RNA polymerase (RNAP) binding protein conserved in numerous bacterial species and essential in mycobacteria. Despite the importance of CarD, its function at ...
Cho Ginam G Department of Pathology, Brigham and Women's Hospital and Harvard Medical School; Department of Pathology and Laboratory Medicine, Children's Hospital of - - 2014
Mutations in the Aristaless related homeodomain transcription factor (ARX) are associated with a diverse set of X-linked mental retardation and epilepsy syndromes in humans. Although most studies have been focused on its function in the forebrain, ARX is also expressed in other regions of the developing nervous system including the ...
Yeh Shu-Dan SD Department of Ecology and Evolutionary Biology, University of California Irvine, CA - - 2014
MicroRNAs (miRNAs) are endogenous RNA molecules that regulate gene expression post-transcriptionally. To date, the emergence of miRNAs and their patterns of sequence evolution have been analyzed in great detail. However, the extent to which miRNA expression levels have evolved over time, the role different evolutionary forces play in shaping these ...
Rønnekleiv Oline K OK Department of Physiology & Pharmacology, OR Health & Science University, Portland, OR 97239, - - 2014
The hypothalamic arcuate nucleus controls many critical homeostatic functions including energy homeostasis, reproduction and motivated behavior. Although, G-protein-coupled receptors (GPCRs) are involved in the regulation of these functions, relatively few of the GPCRs have been identified specifically within the arcuate nucleus. Here, using TaqMan low density arrays we quantified the ...
Herriges Michael J MJ Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2014
Long noncoding RNAs (lncRNAs) are thought to play important roles in regulating gene transcription, but few have well-defined expression patterns or known biological functions during mammalian development. Using a conservative pipeline to identify lncRNAs that have important biological functions, we identified 363 lncRNAs in the lung and foregut endoderm. Importantly, ...
Filloux Cyril - - 2014
Transcriptome sequencing is a powerful tool for measuring gene expression, but as well as some other technologies, various artifacts and biases affect the quantification. In order to correct some of them, several normalization approaches have emerged, differing both in the statistical strategy employed and in the type of corrected biases. ...
Bakele Martina M University of Tuebingen, - - 2014
CXCL8 (IL-8) recruits and activates neutrophils through the G protein-coupled chemokine receptor CXCR1. We showed previously that elastase cleaves CXCR1 and thereby impairs antibacterial host defense. However, the molecular intracellular machinery involved in this process remained undefined. Here we demonstrate, by using flow cytometry, confocal microscopy, subcellular fractionation, Co-IP and ...
Ghosh Sanjay S European Molecular Biology Laboratory, Heidelberg, - - 2014
In eukaryotes, RNA processing events in the nucleus influence the fate of transcripts in the cytoplasm. The multi-protein exon junction complex (EJC) associates with mRNAs concomitant with splicing in the nucleus and plays important roles in export, translation, surveillance and localization of mRNAs in the cytoplasm. In mammalian cells, the ...
Nadarajah Saralees S School of Mathematics, University of Manchester, Manchester M13 9PL, United - - 2014
Bandi et al. [Phys. Rev. E 79, 016309 (2009)] reported a closed form expression for the probability density function of the product of two correlated normal random variables and proposed an approximation for the distribution of its mean. Here, we question the closed form expression and derive exact expressions for the ...
Hu Jin-Yong JY Department of Plant Breeding and Genetics, Max-Planck-Institute for Plant Breeding Research, 50829 Cologne, Germany - - 2014
The timing of flowering is pivotal for maximizing reproductive success under fluctuating environmental conditions. Flowering time is tightly controlled by complex genetic networks that integrate endogenous and exogenous cues, such as light, temperature, photoperiod, and hormones. Here, we show that AGAMOUS-LIKE16 (AGL16) and its negative regulator microRNA824 (miR824) control flowering ...
Lai Ya-Shiuan - - 2014
Whether structure and function are correlated features of organelles is a fundamental question in cell biology. Here we have queried the ability of mutants with defective structure of the endoplasmic reticulum (ER) to invoke the unfolded protein response (UPR), an essential ER signaling pathway. Through molecular and genetic approaches we ...
Fechter Pierre P Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 15 Rue René Descartes 67084 - - 2014
A plethora of RNAs with regulatory functions has been discovered in many non-pathogenic and pathogenic bacteria. In Staphylococcus aureus, recent findings show that a large variety of RNAs control target gene expression by diverse mechanisms and many of them are expressed in response to specific internal or external signals. These ...
Qin Yao Y State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong 271018, People's Republic of China Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of - - 2014
In this study, we carried out an evolutionary, transcriptional, and functional analyses of the trihelix transcription factor family. A total of 319 trihelix members, identified from 11 land plant species, were classified into five clades. The results of phylogeny indicate the binding domains of GT1 and GT2 diverged early in ...
Pećina-Šlaus Nives N Laboratory of Neurooncology, Croatian Institute for Brain Research, and Department of Biology, School of Medicine, University of Zagreb, Zagreb, Croatia. - - 2014
Since the discovery of the TCF/LEF family of transcription factors, their functions have been under intensive investigation in the area of cancer biology. The work presented in this paper focused on the changes in TCF-1 and LEF-1 expression levels in a set of astrocytic brain tumors. Protein expression was detected ...
Aftabuddin Md M West Bengal University of Technology, Kolkata 700064, - - 2014
MicroRNAs (miRNAs) interact with their target mRNAs and regulate biological processes at post-transcriptional level. While one miRNA can target many mRNAs, a single mRNA can also be targeted by a set of miRNAs. The targeted mRNAs may be involved in different biological processes that are described by gene ontology (GO) ...
Verzillo Vittorio V Department of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, 11203, Brooklyn, New - - 2014
The gene encoding the mu-opioid receptor (MOR) generates a remarkable diversity of subtypes, the functional significance of which remains largely unknown. The structure of MOR could be a critical determinant of MOR functionality and its adaptations to chronic morphine exposure. Since MOR antinociception has sexually dimorphic dimensions, we determined the ...
Nitzan Mor M Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem, Israel; Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, - - 2014
Competing endogenous RNAs (ceRNAs) were recently introduced as RNA transcripts that affect each other's expression level through competition for their microRNA (miRNA) coregulators. This stems from the bidirectional effects between miRNAs and their target RNAs, where a change in the expression level of one target affects the level of the ...
Srimontri Paitoon P Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto, 603-8555, - - 2014
Growth hormone (GH) has been implicated in a variety of brain functions, including neural development, cognition, and neuroprotection. The biological effects of GH are known to rely on the binding of GH to the GH receptor (GHR), yet the resulting signals in the brain remain poorly understood. The present study ...
Wu Chao C Department of Computer Science, University of Cincinnati, Cincinnati, OH 45221, USA Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, - - 2014
Identifying functionally significant microRNAs (miRs) and their correspondingly most important messenger RNA targets (mRNAs) in specific biological contexts is a critical task to improve our understanding of molecular mechanisms underlying organismal development, physiology and disease. However, current miR-mRNA target prediction platforms rank miR targets based on estimated strength of physical ...
Arámburo Carlos C Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, 76230, México. Electronic address: - - 2014
There is increasing evidence that growth hormone (GH) expression is not confined exclusively to the pituitary somatotrophs as it is synthesized in many extrapituitary locations. The nervous system is one of those extrapituitary sites. In this brief review we summarize data that substantiate the expression, distribution and characterization of neural ...
Miyamura Koichi K Department of Hematology, Japanese Red Cross Nagoya First - - 2014
In a multicenter study, we evaluated the Major BCR-ABL mRNA/ABL mRNA quantification kit (M135R), which uses reference material included in the kit designed to report results using the international scale (IS). In total, 127 samples were studied. A good correlation was observed between M135R results and home-brew RT-qPCR results, which ...
Noorlag Rob R Department of Oral and Maxillofacial Surgery, University Medical Center Utrecht, Utrecht, The - - 2014
Background Gene expression profiling revealed a strong signature predicting lymph node metastases (LNM) in oral squamous cell carcinoma (OSCC). Four of the most predictive genes are secretory leukocyte protease inhibitor (SLPI), lipocalin-2 (LCN2), thrombospondin-2 (THBS2) and tumor-associated calcium signal transducer 2 (TACSTD2). This study correlates their protein expression with LNM, ...
Bedont Joseph L JL Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, - - 2014
Vertebrate circadian rhythms are organized by the hypothalamic suprachiasmatic nucleus (SCN). Despite its physiological importance, SCN development is poorly understood. Here, we show that Lim homeodomain transcription factor 1 (Lhx1) is essential for terminal differentiation and function of the SCN. Deletion of Lhx1 in the developing SCN results in loss of ...
Gebhardt Marie L ML Max Delbrück Center for Molecular Medicine, Berlin 13125, - - 2014
There are groups of genes that need coordinated repression in multiple contexts, for example if they code for proteins that work together in a pathway or in a protein complex. Redundancy of biological regulatory networks implies that such coordinated repression might occur at both the pre- and post-transcriptional level, though ...
Li Caili - - 2014
MYB is the largest plant transcription factor gene family playing vital roles in plant growth and development. However, it has not been systematically studied in Salvia miltiorrhiza, an economically important medicinal plant. Here we report the genome-wide identification and characterization of 110 R2R3-MYBs, the largest subfamily of MYBs in S. ...
Marquardt Sebastian S Department of Cell & Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, - - 2014
Antisense transcription is widespread in many genomes; however, how much is functional is hotly debated. We are investigating functionality of a set of long noncoding antisense transcripts, collectively called COOLAIR, produced at Arabidopsis FLOWERING LOCUS C (FLC). COOLAIR initiates just downstream of the major sense transcript poly(A) site and terminates either ...
Wang Shufen S Key Laboratory of Horticultural Plant Biology, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, - - 2014
The tomato (Solanum lycopersicum) protein MADS-RIN plays important roles in fruit ripening. In this study, the functions of two homologous tomato proteins, FUL1 and FUL2, which contain conserved MIKC domains that typify plant MADS-box proteins, and which interact with MADS-RIN, were analysed. Transgenic functional analysis showed that FUL1 and FUL2 ...
Song Xiaodong X Medicine Research Center, Binzhou Medical University, Yantai, - - 2014
Long non-coding RNAs (lncRNAs) are involved in various pathophysiologic processes and human diseases. However, their dynamics and corresponding functions in pulmonary fibrosis remain poorly understood. In this study, portions of lncRNAs adjacent or homologous to protein-coding genes were determined by searching the UCSC genome bioinformatics database. This was found to ...
Marano Robert J RJ Ear Science Institute Australia (R.J.M.), Subiaco, Western Australia, 6008, Australia; Ear Sciences Centre, School of Surgery (R.J.M.), The University of Western Australia, Nedlands, Western Australia, 6009, Australia; and Department of Cancer Biology (N.B-J.), University of Cincinnati Medical School, Cincinnati, Ohio - - 2014
Prolactin (PRL) is an important hormone with many diverse functions. Although it is predominantly produced by lactrotrophs of the pituitary there are a number of other organs, cells, and tissues in which PRL is expressed and secreted. The impact of this extrapituitary PRL (ePRL) on localized metabolism and cellular functions ...
Celton Jean-Marc JM INRA, UMR1345 Institut de Recherche en Horticulture et Semences, 49071, Beaucouzé, - - 2014
Characterizing the transcriptome of eukaryotic organisms is essential for studying gene regulation and its impact on phenotype. The realization that anti-sense (AS) and noncoding RNA transcription is pervasive in many genomes has emphasized our limited understanding of gene transcription and post-transcriptional regulation. Numerous mechanisms including convergent transcription, anti-correlated expression of ...
Park Ju Young JY Cancer Cell and Molecular Biology Branch, Research Institute, National Cancer Center, Goyang, - - 2014
More than 98% of eukaryotic tanscriptomes are composed of non-coding RNAs with no functional protein-coding capacity. Those transcripts also include tens of thousands of long non-coding RNAs (lncRNAs) which are emerging as key elements of cellular homeostasis, essentially tumorigenesis steps. However, we are only beginning to understand the nature and ...
Ramakrishnan Kalpana K Department of Biological Sciences, University of Illinois at Chicago, 900 S. Ashland Avenue (MC567), Chicago, IL 60607, - - 2014
M4 is a multifunctional neuron in the C. elegans pharynx that can both stimulate peristaltic contractions of the muscles in the pharyngeal isthmus and function systemically to regulate an enhanced sensory response under hypoxic conditions. Here we identify a third function for M4 that depends on activation of the TGF-ß ...
Moore Ashleigh E AE Alexandria Center for Life Sciences, New York University School of Medicine, New York, NY, - - 2014
Regulated messenger RNA (mRNA) decay is an essential mechanism that governs proper control of gene expression. In fact, many of the most physiologically potent proteins are encoded by short-lived mRNAs, many of which contain AU-rich elements (AREs) in their 3'-untranslated region (3'-UTR). AREs target mRNAs for post-transcriptional regulation, generally rapid ...
Ruby Plant Tissue Culture Division, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, Maharashtra, - - 2014
Health related benefits of isoflavones such as genistein are well known. Glycosylation of genistein yields different glycosides like genistein 7-O-glycoside (genistin) and genistein 4'-O-glycoside (sophoricoside). This is the first report on isolation, cloning and functional characterization of a glycosyltransferase specific for genistein 4'-O-glucoside from Bacopa monniera, an important Indian medicinal ...
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