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Ghosh Asish K AK Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, Illinois, - - 2014
Fibrosis, the deadly pathological manifestation of an abnormal tissue remodeling in any organ due to excessive collagen deposition, is associated with a wide variety of organ failure-related human diseases. Chronic stress or repeated injury in a particular organ induces abnormal molecular signals that lead to super-activation of matrix protein producing ...
Shabab Mohammed M Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 8, D-07745, Jena, - - 2014
12-oxophytodienoic acid (OPDA), a well-known phytohormone of the jasmonate family, has a reactive α,β-unsaturated carbonyl structure which easily adds cellular nucleophiles (Michael addition), making OPDA potentially toxic for herbivores. The glutathione S-transferase GST16 inactivates 12-OPDA in the insect gut by isomerization to inactive iso-OPDA. Quantitative tissue expression analysis showed that ...
Lin Yi-Yu YY Department of Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, - - 2014
White adipose tissue (WAT) releases fatty acids from stored triacylglycerol (TAG) for energy source. Here, we report that targeted deletion of KH-type splicing regulatory protein (KSRP), an RNA-binding protein that regulates gene expression at multiple levels, enhances lipolysis in epididymal WAT (eWAT) due to up-regulation of genes promoting lipolytic activity. ...
Li Ping P Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, - - 2014
Trefoil factor family (TFF) peptides are mucin-associated secretory products that are produced in the airways and gastrointestinal tract. These peptides appear to play an important role in mucosal healing and epithelial protection and are overexpressed in chronically inflamed gastrointestinal tissues. We hypothesize that TFF peptides may also be differentially expressed ...
Wang Yan Y Laboratory of Animal Genetic and Breeding, Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Ya'an, 625014, Sichuan, - - 2014
In this study, we quantified the expression of CRBP1 and CRBP3 in Roman layer (R) and Erlang mountainous chickens (SD02 and SD03), to discern the tissue, breed and age-related expression patterns in order to discover potential involvement in egg production and other related reproduction traits. Real-time quantitative PCR assays were ...
Bleul Tim T Department of General Surgery, University Hospital Heidelberg, Heidelberg, - - 2014
Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest cancers in the world. All-trans retinoic acid (ATRA) is the major physiologically active form of vitamin A, regulating expression of many genes. Disturbances of vitamin A metabolism are prevalent in some cancer cells. The main aim of this work was to ...
Kruithof E K O EK Egbert K.O. Kruithof, Division of Angiology and Hemostasis, Department of internal medicine, University Hospital of Geneva and Faculty of Medicine of the University of Geneva, University Medical Center CMU 9094, 1 Rue Michel Servet, CH1211 Geneva 4, Switzerland, Tel.: +41 22 3795493, E-mail: - - 2014
Tissue-type plasminogen activator (t-PA ) plays an important role in the removal of intravascular fibrin deposits and has several physiological roles and pathological activities in the brain. Its production by many other cell types suggests that t-PA has additional functions outside the vascular and central nervous system. Activity of t-PA ...
Zhang Yi Y Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou 510080, - - 2014
The homeobox gene Barx2 was recently identified as a regulator of ovarian and breast cancer; however, the expression level of BARX2 and its significance in hepatocellular carcinoma (HCC) remain unknown. Protein and mRNA expression levels of Barx2 were examined using Western blotting and real-time PCR respectively, in paired HCC tissue ...
Hong Zhuan Z State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, 22 Hankou Road, Nanjing, 210093, Poeple's Republic of - - 2014
The activation of the hedgehog pathway, which is an important signaling mechanism crucial in embryogenesis, has strong links to carcinogenesis. Aberrant regulation of this pathway can result in the development of tumors. The present study was designed to investigate Hh related protein expression in non-small cell lung cancers. Fifty five ...
Deng Lili - - 2014
gamma-tocotrienol (GT3), an analogue of vitamin E, has gained increasing scientific interest recently as it provides significant health benefits. It has been shown that emulsified GT3, after subcutaneous administration, has long-term biological effects. However, whether the effects are due to the increase of GT3 level in the early phase following ...
Wichmann Henri H Department of Radiotherapy, Martin-Luther-University of Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany, - - 2014
Human epidermal growth factor receptor 2 (ErbB2) is overexpressed in a variety of human malignancies. Moreover, ErbB2 has been reported to influence cancer patient survival and progression of different tumor entities. However, information regarding the prognostic impact of ErbB2 in soft tissue sarcoma (STS) patients is limited and conflicting. ErbB2 mRNA ...
Zhan Ping P Department of Gynecology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. - - 2014
The aim of the present study was to examine the expression of integrin β1 in squamous cell carcinoma (SCC) of the cervix and its association with the clinicopathological features of patients. The expression of integrin β1 in 87 SCC cervical tissues and 32 normal cervical tissues was detected using an enzyme‑linked immunosorbent assay, western ...
Li He-Xiang HX Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Ningbo University, Ningbo 315211, - - 2014
Liver-expressed antimicrobial peptide 2 (LEAP-2) plays a vital role in the host innate immune system. In the present study, two LEAP-2 genes (LcLEAP-2A and LcLEAP-2C) from large yellow croaker (Larimichthys crocea) were cloned, both of which consist of 3 exons and 2 introns. The LcLEAP-2A transcripts were expressed in a ...
Kurashima Yosuke Y Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 102-0075, Japan; Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan; Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, - - 2014
Mast cells (MCs) mature locally, thus possessing tissue-dependent phenotypes for their critical roles in both protective immunity against pathogens and the development of allergy or inflammation. We previously reported that MCs highly express P2X7, a receptor for extracellular ATP, in the colon but not in the skin. The ATP-P2X7 pathway ...
Liu W-L WL Allergy and Cancer Center, Otorhinolarygology Hospital, The First Affiliated Hospital of Sun Yat-sen University; Department of Otolaryngology, Guangzhou Women and Children's Medical Center, - - 2014
Osteopontin (OPN) has been proposed to be associated with airway inflammation including asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). This study sought to evaluate the expression and regulation of the OPN in CRSwNP patients. Nasal polyp (NP) tissues and normal tissues were collected from 30 CRSwNP patients and 16 ...
Zhou Lin L State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China; The 88th Hospital of PLA, Tai'an, 271000, - - 2014
Prion protein (PrPc) has been previously reported to be involved in gastric cancer(GC) development and progression. However, the association between expression of PrPc and GC prognosis is yet poorly characterized. In the present study, the expressions of PrPc and MGr1-Ag/37LRP, a protein interacting with PrPc, were detected using the tissue ...
Richards Jacob J Department of Medicine, University of Florida; Department of Biochemistry and Molecular Biology, University of - - 2014
The present study is designed to consider a role for the circadian clock protein Per1 in the regulation of the endothelin axis in mouse kidney, lung, liver and heart. Renal endothelin-1 (ET-1) is a regulator of the epithelial sodium channel (ENaC) and blood pressure (BP), via activation of both endothelin ...
Volkoff Hélène H Departments of Biology and Biochemistry, Memorial University of Newfoundland, St. John's, NL, A1B 3X9 Canada. Electronic address: - - 2014
cDNAs encoding the appetite regulating peptides apelin, cocaine and amphetamine regulated transcript (CART), cholecystokinin (CCK), peptide YY (PYY) and orexin were isolated in red-bellied piranha and their mRNA tissue and brain distributions examined. When compared to other fish, the sequences obtained for all peptides were most similar to that of ...
Flood Diana E K DE Department of Chemistry and Chemical Engineering, Royal Military College of Canada, ON, CA;and Biology Department, Queen's University, Kingston, ON, CA. Electronic address: - - 2014
The objectives of this study were to examine the effects of potassium perchlorate (KClO4) treatment on androgen- and thyroid hormone (TH)-related transcript levels during gonadogenesis in the frog Silurana tropicalis. Androgen- and TH-related gene expression was examined in gonad-mesonephros complex (GMC) and liver tissues at stage NF 56 and stage ...
Simões Priscila Santos Rodrigues PS Neurology/Neurosurgery Department, Federal University of São Paulo (UNIFESP), São Paulo, - - 2014
Thimet oligopeptidase (TOP) is a metalloprotease that has been associated with peptide processing in several nervous system structures, and its substrates include several peptides such as bradykinin, amyloid beta (Aβ), and major histocompatibility complex (MHC) class I molecules. As shown previously by our research group, patients with temporal lobe epilepsy ...
Fang Di-An DA Scientific Observing and Experimental Station of Fishery Resources and Environment in the Changjiang River, Freshwater Fisheries Research Center, Wuxi, Shanshui Road 9, 214081, - - 2014
Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2 in the presence of sulfhydryl compounds. In this study, a full length PGDS gene comprising 1250 nucleotides from the Chinese mitten crab Eriocheir sinensis (Es-PGDS) was characterized, with a 615bp open reading frame encoding 204 amino acid residues. ...
Jianmin Zou Z a Institute of Poultry Science , Chinese Academy of Agricultural Science , Yangzhou , - - 2014
The IGF system is one of the most important endocrine and paracrine growth factor systems that regulate fetal and placental growth, whereas the liver is the principal source of circulation IGF-I. In the present study, expression of IGF-I, IGF type-I receptor (IGF-IR), and IGF binding protein (IGFBP)-3 genes was quantified ...
Wang X X Department of Gynecology, Laiwu People's Hospital, 001 Xuehu avenue, Laiwu, 271100, China, - - 2014
The present study aimed to investigate the expression level of MicroRNA-25 (miR-25) in epithelial ovarian cancer (EOC) tissue, and examine its relationship with clinicopathological factors and prognosis of patients with EOC. Expression levels of miR-25 in 86 pairs of EOC tissue and adjacent normal tissue were measured by quantitative real-time ...
Kanda Mitsuro M Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan, - - 2014
Patients with advanced gastric cancer (GC) have an adverse prognosis even after curative resection. Development of novel diagnostic and therapeutic approaches for GC is urgently required. The expression and methylation status of DENN/MADD domain-containing protein 2D (DENND2D), a member of the membrane trafficking proteins, were evaluated in 12 GC cell ...
Wang Tao T Department of Aquaculture, Sichuan Agricultural University, 46# Xinkang Road, Ya'an, 625014, - - 2014
Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. For a better understanding of the structure and function of the CRH gene and to study its effect on feeding regulation in cyprinid fish, the cDNA of the CRH gene from the brain of ...
Samyesudhas Serene J SJ Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, South Bend, IN, USA. Electronic address: - - 2014
ARID3B is a DNA binding protein that is overexpressed in neuroblastoma and ovarian cancer. To understand the extent that ARID3B participates in tumor development, we assessed protein expression of ARID3B in normal adult and malignant tissues. We found that ARID3B is highly expressed in differentiated layers of squamous epithelium. We ...
von Klot Christoph-A J - - 2014
Galectins are known to regulate cell differentiation and growth as well as cell adhesion and apoptosis. Galectins have been discussed as possible prognosticators for survival in renal cell cancer (RCC) and other urological tumors. They might also play an emerging role as possible new marker-proteins for RCC. In this study, ...
Wan Zhiyi Z State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, No.2 Yuan Ming Yuan West Road, Beijing, 100193, People's Republic of - - 2014
PRDM1 (PR domain containing 1) is a transcriptional repressor that has been identified in various species and is crucial for cell growth, differentiation and development. However, the expression pattern and role of PRDM1 in development has not been sufficiently established in birds. We therefore investigate the spatio-temporal expression of PRDM1 ...
Kanda Mitsuro M Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, - - 2014
The prognosis of advanced gastric cancer (GC) remains dismal. The aim of this study was to identify a novel tumor suppressor gene (TSG) with repressed transcription by aberrant DNA methylation in GC. The expression and methylation status of tumor suppressor candidate 1 (TUSC1) were evaluated in GC cell lines and ...
Aso Teppei T From the Departments of *Surgery and Oncology, and †Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, - - 2014
Aberrant expression of several microRNAs (miRs) has been reported in various neoplasms including intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. MicroRNA-196a (miR-196a) is up-regulated in Barrett esophagus (characterized by intestinal metaplasia) and in colorectal cancer; this relationship between intestinal characteristics and miR-196a might also be applicable to intestinal-type IPMNs. ...
Gauff Felicia C FC Department of Horses and Small Animals, University of Veterinary Medicine Vienna, A-1210 Vienna, - - 2014
Objective-To determine the effect of short-term hyperinsulinemia on the localization and expression of endothelin receptor (ETR)-A and ETR-B in lamellar tissue of the forelimbs of horses. Samples-Distal portion of 15 cadaveric forelimbs from healthy adult horses (1 limb/horse) obtained immediately after slaughter at an abattoir. Procedures-Each forelimb was assigned to ...
Assefnia Shahin S S Assefnia, Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, United - - 2014
Trp63, founding member of the Trp53 family, contributes to epithelial differentiation and is expressed in breast neoplasia. Trp63 features two distinct promoters yielding specific mRNAs encoding two major TRP63 isoforms, a transactivating transcription factor and a dominant negative isoform. Specific TRP63 isoforms are linked to cell cycle arrest, apoptosis, survival ...
Yang Wen-Bing WB Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China, - - 2014
The abnormal expression of MUC15, a novel cell membrane-associated mucin, has been reported to predict poor survival in several cancers. The aim of the present study was to examine the expression of MUC15 in glioma and its correlation with clinicopathological features, including the survival of patients with glioma. The mRNA ...
Varelas Xaralabos X Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Room K-620, Boston, MA 02118, - - 2014
Studies over the past 20 years have defined the Hippo signaling pathway as a major regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have emerged, the majority of which in vertebrates are determined by the transcriptional regulators TAZ and YAP (TAZ/YAP). Key processes regulated by ...
Yu Yaping - - 2014
Previous studies have shown that lactate dehydrogenase-A (LDH-A) is strongly expressed in several malignancies, that LDH-A expression is associated with poor prognosis, and that LDH-A inhibition severely diminishes tumorigenicity. However, little is known about the implications of LDH-A expression in intrahepatic cholangiocarcinoma. The purpose of this study was to investigate ...
Zheng Jiexing J Burn Center, Ruijin Hospital, Jiaotong University Medical School, Shanghai, - - 2014
The skin color of human hypertrophic scar changes dynamically during scar progression. To investigate whether hypoxia is dynamic during scar progression. Thirty-five patients with early, proliferative, regressive, and mature scars were involved in this study. Tissue oxygen tension was measured before scar surgery. After surgery, the scar stage was further ...
Hu Kunpeng K Department of General Surgery, Lingnan Hospital of Sun Yat-sen University, Guangzhou, China, - - 2014
The molecular mechanisms of the development and progression of hepatocellular carcinoma (HCC) are poorly understood. The main objective of this study was to analyze the expression of Enabled [mammalian Ena (Mena)] protein and its clinical significance in human HCC. The Mena expression was examined at mRNA and protein levels by ...
Lin Xu-Yong XY Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110001, - - 2014
Large tumor suppressor (LATS) is a Ser/Thr kinase originally isolated from Drosophila. Recent studies demonstrate that LATS is an important member of the Hippo pathway which can regulate organ size and cell proliferation. However, little is known about the expression and clinical significance of LATS in lung cancer. In this ...
Estep J M JM Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United - - 2014
Non-alcoholic fatty liver disease (NAFLD) is strongly associated with visceral adiposity. The secretion of adipocytokines from white adipose tissue promoting necroinflammation, and/or fibrosis may play important roles in the pathogenesis of non-alcoholic steatohepatits (NASH). In a previous study, reduced expression of a number of miRNA species in white adipose tissue ...
Jahns Franziska F Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany; Department of Single Cell and Single Molecule Techniques, Leibniz Institute for Age Research - Fritz Lipmann Institute, Jena, - - 2014
The induction of antioxidant enzymes is an important mechanism in colon cancer chemoprevention, but the response of human colon tissue to butyrate, a gut fermentation product derived from dietary fiber, remains largely unknown. Therefore, our study investigated the effect of a butyrate treatment on catalase (CAT) and superoxide dismutase (SOD2) ...
Andreasen E B EB Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, - - 2014
Tissue factor (TF) expression in human cancers has been associated with a procoagulant state and facilitation of metastasis. This study was conducted in order to evaluate if TF was expressed in canine mammary tumours. Forty epithelial mammary tumours from 28 dogs were included. TF expression of the tumours was evaluated ...
Wang Dan D Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, People's Republic of - - 2014
Objectives Previous studies have suggested that the expression and function of placenta-specific microRNAs (miRNAs) are associated with placenta trophoblastic proliferation and invasion. This study investigated whether the altered expression of placenta-specific miRNAs was involved in the development of fetal growth. Methods Placenta tissues were obtained from pregnant women with large for gestational ...
Zhang Er-Bao EB Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, - - 2014
Gastric cancer (GC) is one of the most frequent cancers worldwide. Recent studies have shown that long noncoding RNAs (lncRNAs) play critical roles in multiple biological processes, including oncogenesis. The present study aimed to evaluate the potential role of lncRNA H19 in GC. qRT-PCR was performed to investigate the expression ...
Wang You Y Shanghai Key Laboratory of Gynecologic Oncology, Focus Construction Subject of Shanghai Education Department, Shanghai, 200127, - - 2014
To elucidate the clinicopathological significance and the role of Jun Activation Domain-Binding Protein 1 (JAB1), Ser10-phosphorylated p27 (p27S10), and total p27 in human hepatocellular carcinoma (HCC) prognosis. We evaluated the expression of JAB1 and p27S10 in tissues by immunohistochemical and immunoblot analyses. p27 Ser10 phosphorylation and Ser10 phosphorylation-dependent p27-JAB1 interaction ...
Yu Kaifan K State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510006, P.R. - - 2014
Adipose tissue is crucial for energy homeostasis, and it has been a topic interest to investigate the regulation of adipose tissue formation for the ever-increasing health concerns of obesity and type 2 diabetes. Adipocyte differentiation is tightly regulated by characteristic sequential expression change of adipocyte genes, including members of the ...
Suzuki Daisuke D Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, - - 2014
The Wnt signaling pathway is essential for cell fate decisions during embryonic development as well as for homeostasis after birth. Dapper-antagonist-of-catenin1 (Dact1) plays an important role during embryogenesis by regulating Wnt signaling pathways. Consequently, targeted disruption of the Dact1 gene in mice leads to perinatal lethality due to severe developmental ...
Carbonell-Bejerano Pablo - - 2014
Temperature and solar radiation influence Vitis vinifera L. berry ripening. Both environmental conditions fluctuate cyclically on a daily period basis and the strength of this fluctuation affects grape ripening too. Additionally, a molecular circadian clock regulates daily cyclic expression in a large proportion of the plant transcriptome modulating multiple developmental ...
Leung King Pong KP School of Life Sciences, The Chinese University of Hong Kong, Sha Tin, N.T., Hong Kong Special Administrative Region, China. - - 2014
Zebrafish (Danio rerio) is a freshwater fish species of Cyprinidae known for its copper (Cu) intolerance, yet the underlying mechanisms of the sensitivity remain unclear. In this study, we examined the highly conserved molecular machineries in the copper handling system, namely ATOX1, ATP7A, ATP7B, and CTR1, by profiling their gene ...
Singh Indrabahadur - - 2014
The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development and their levels are strongly reduced in the corresponding adult tissues, where they have been implicated in maintaining and activating stem/progenitor cells. Here we deciphered ...
Lee I H IH Department of Life Sciences and GT5 program, Ewha Womans University, Seoul, - - 2014
We provide detailed mechanisms of Ahnak-mediated potentiation of transforming growth factor β (TGFβ) signaling, which leads to a negative regulation of cell growth. We show that Smad3 interacts with Ahnak through MH2 domain and that Ahnak stimulates Smad3 localization into nucleus leading to potentiating TGFβ-induced transcriptional activity of R-Smad. Moreover, ...
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