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Mouallif Mustapha M Laboratory of Experimental Pathology, GIGA-Cancer, University of Liège, Liège, Belgium; Laboratory of Virology and Hygiene & Microbiology, University Hassan II-Mohammedia, Mohammedia, - - 2014
Undifferentiated cell Transcription Factor 1 (UTF1) is a chromatin-bound protein involved in stem cell differentiation. It was initially reported to be restricted to stem cells or germinal tissues. However, recent work suggests that UTF1 is also expressed in somatic cells and that its expression may increase during carcinogenesis. To further ...
Brychtova Veronika V Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 65653 Brno, Czech - - 2014
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice but is often difficult to achieve. The ...
Harvey Steve S Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. Electronic address: - - 2014
While growth hormone (GH) is obligatory for postnatal growth, it is not required for a number of growth-without-GH syndromes, such as early embryonic or fetal growth. Instead, these syndromes are thought to be dependent upon local growth factors, rather than pituitary GH. The GH gene is, however, also expressed in ...
Tsou Pei-Suen PS University of - - 2014
Tissue fibrosis occurs with excessive extracellular matrix (ECM) deposition from myofibroblasts resulting in tissue scarring and inflammation. It is driven by multiple mediators, such as the G-protein coupled receptor ligands lysophosphatidic acid (LPA) and endothelin (ET-1) as well as signaling by transforming growth factor β (TGFβ), connective tissue growth factor ...
Unal Guler G Yuzunçu Yil University, Science Faculty, Department of Biology, Van 65080-Turkey. Electronic address: - - 2014
Reproductively arrested gonadal development has been previously described in the teleost pearl mullet (Chalcalburnus tarichi, Cyprinidae) from Van Edremit Gulf of Lake Van, Turkey. Oocyte development in some females was arrested at the previtellogenic stage, while gonadosomatic index (GSI) and plasma 17β-estradiol (E2) level were low. A subset of the ...
Ghosh Asish K AK Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, Illinois, - - 2014
Fibrosis, the deadly pathological manifestation of an abnormal tissue remodeling in any organ due to excessive collagen deposition, is associated with a wide variety of organ failure-related human diseases. Chronic stress or repeated injury in a particular organ induces abnormal molecular signals that lead to super-activation of matrix protein producing ...
Wang Ying Y Oncology Department of the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, - - 2014
Background/Aims: Long noncoding RNAs (lncRNAs) are pervasively transcribed and have been shown to regulate key biological processes that maintain normal cellular functions. Abnormal regulation of these lncRNAs can promote tumorigenesis through resulting aberrant cellular essential functions. however, the roles of lncRNAs played in the development of gastric cardiac adenocarcinoma (GCA) ...
Mladenovic Zvezdana Z From the University Pierre and Marie Curie, Paris; Pierre Fabre Laboratories, Castres; Labex Transimmunomics, DHU i2B, Paris; Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, - - 2014
To determine the effect of hyaluronic acid (HA) on proteolytic enzymes and bone remodeling mediators induced by interleukin 1b (IL-1β) and related to cartilage catabolism in murine osteoblasts. Osteoblasts were obtained from Swiss mice and cultured for 3 weeks. HA-treated osteoblasts were incubated with 100 μg/ml HA during the last ...
Shabab Mohammed M Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 8, D-07745, Jena, - - 2014
12-oxophytodienoic acid (OPDA), a well-known phytohormone of the jasmonate family, has a reactive α,β-unsaturated carbonyl structure which easily adds cellular nucleophiles (Michael addition), making OPDA potentially toxic for herbivores. The glutathione S-transferase GST16 inactivates 12-OPDA in the insect gut by isomerization to inactive iso-OPDA. Quantitative tissue expression analysis showed that ...
Lin Yi-Yu YY Department of Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, - - 2014
White adipose tissue (WAT) releases fatty acids from stored triacylglycerol (TAG) for energy source. Here, we report that targeted deletion of KH-type splicing regulatory protein (KSRP), an RNA-binding protein that regulates gene expression at multiple levels, enhances lipolysis in epididymal WAT (eWAT) due to up-regulation of genes promoting lipolytic activity. ...
Li Ping P Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, - - 2014
Trefoil factor family (TFF) peptides are mucin-associated secretory products that are produced in the airways and gastrointestinal tract. These peptides appear to play an important role in mucosal healing and epithelial protection and are overexpressed in chronically inflamed gastrointestinal tissues. We hypothesize that TFF peptides may also be differentially expressed ...
Sun Xicai X Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, - - 2014
Although JNA is a benign neoplasm histopathologically, it has a propensity for locally destructive growth and remains a higher postoperative recurrence rate. The aim of this study was to analyze the expression and localization of MMP-9 in JNA using tissue microarray to elucidate its correlation with clinicopathological features and recurrence. ...
Wang Yan Y Laboratory of Animal Genetic and Breeding, Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Ya'an, 625014, Sichuan, - - 2014
In this study, we quantified the expression of CRBP1 and CRBP3 in Roman layer (R) and Erlang mountainous chickens (SD02 and SD03), to discern the tissue, breed and age-related expression patterns in order to discover potential involvement in egg production and other related reproduction traits. Real-time quantitative PCR assays were ...
Bleul Tim T Department of General Surgery, University Hospital Heidelberg, Heidelberg, - - 2014
Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest cancers in the world. All-trans retinoic acid (ATRA) is the major physiologically active form of vitamin A, regulating expression of many genes. Disturbances of vitamin A metabolism are prevalent in some cancer cells. The main aim of this work was to ...
Scorilas Andreas - - 2014
Abstract Several members of the family of tissue kallikrein and kallikrein-related peptidases have been suggested as promising tumor biomarkers with important prognostic significance. However, only one (KLK11) has already been studied in laryngeal squamous cell carcinoma (LSCC) as potential biomarker for LSCC diagnosis and/or prognosis. Our study investigated the prognostic ...
Zhang Yi Y Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou 510080, - - 2014
The homeobox gene Barx2 was recently identified as a regulator of ovarian and breast cancer; however, the expression level of BARX2 and its significance in hepatocellular carcinoma (HCC) remain unknown. Protein and mRNA expression levels of Barx2 were examined using Western blotting and real-time PCR respectively, in paired HCC tissue ...
Kruithof E K O EK Egbert K.O. Kruithof, Division of Angiology and Hemostasis, Department of internal medicine, University Hospital of Geneva and Faculty of Medicine of the University of Geneva, University Medical Center CMU 9094, 1 Rue Michel Servet, CH1211 Geneva 4, Switzerland, Tel.: +41 22 3795493, E-mail: - - 2014
Tissue-type plasminogen activator (t-PA ) plays an important role in the removal of intravascular fibrin deposits and has several physiological roles and pathological activities in the brain. Its production by many other cell types suggests that t-PA has additional functions outside the vascular and central nervous system. Activity of t-PA ...
Deng Lili - - 2014
gamma-tocotrienol (GT3), an analogue of vitamin E, has gained increasing scientific interest recently as it provides significant health benefits. It has been shown that emulsified GT3, after subcutaneous administration, has long-term biological effects. However, whether the effects are due to the increase of GT3 level in the early phase following ...
Li He-Xiang HX Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Ningbo University, Ningbo 315211, - - 2014
Liver-expressed antimicrobial peptide 2 (LEAP-2) plays a vital role in the host innate immune system. In the present study, two LEAP-2 genes (LcLEAP-2A and LcLEAP-2C) from large yellow croaker (Larimichthys crocea) were cloned, both of which consist of 3 exons and 2 introns. The LcLEAP-2A transcripts were expressed in a ...
Kurashima Yosuke Y Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 102-0075, Japan; Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan; Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, - - 2014
Mast cells (MCs) mature locally, thus possessing tissue-dependent phenotypes for their critical roles in both protective immunity against pathogens and the development of allergy or inflammation. We previously reported that MCs highly express P2X7, a receptor for extracellular ATP, in the colon but not in the skin. The ATP-P2X7 pathway ...
Wichmann Henri H Department of Radiotherapy, Martin-Luther-University of Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany, - - 2014
Human epidermal growth factor receptor 2 (ErbB2) is overexpressed in a variety of human malignancies. Moreover, ErbB2 has been reported to influence cancer patient survival and progression of different tumor entities. However, information regarding the prognostic impact of ErbB2 in soft tissue sarcoma (STS) patients is limited and conflicting. ErbB2 mRNA ...
Hong Zhuan Z State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, 22 Hankou Road, Nanjing, 210093, Poeple's Republic of - - 2014
The activation of the hedgehog pathway, which is an important signaling mechanism crucial in embryogenesis, has strong links to carcinogenesis. Aberrant regulation of this pathway can result in the development of tumors. The present study was designed to investigate Hh related protein expression in non-small cell lung cancers. Fifty five ...
Zhan Ping P Department of Gynecology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. - - 2014
The aim of the present study was to examine the expression of integrin β1 in squamous cell carcinoma (SCC) of the cervix and its association with the clinicopathological features of patients. The expression of integrin β1 in 87 SCC cervical tissues and 32 normal cervical tissues was detected using an enzyme‑linked immunosorbent assay, western ...
Liu W-L WL Allergy and Cancer Center, Otorhinolarygology Hospital, The First Affiliated Hospital of Sun Yat-sen University; Department of Otolaryngology, Guangzhou Women and Children's Medical Center, - - 2014
Osteopontin (OPN) has been proposed to be associated with airway inflammation including asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). This study sought to evaluate the expression and regulation of the OPN in CRSwNP patients. Nasal polyp (NP) tissues and normal tissues were collected from 30 CRSwNP patients and 16 ...
Richards Jacob J Department of Medicine, University of Florida; Department of Biochemistry and Molecular Biology, University of - - 2014
The present study is designed to consider a role for the circadian clock protein Per1 in the regulation of the endothelin axis in mouse kidney, lung, liver and heart. Renal endothelin-1 (ET-1) is a regulator of the epithelial sodium channel (ENaC) and blood pressure (BP), via activation of both endothelin ...
Volkoff Hélène H Departments of Biology and Biochemistry, Memorial University of Newfoundland, St. John's, NL, A1B 3X9 Canada. Electronic address: - - 2014
cDNAs encoding the appetite regulating peptides apelin, cocaine and amphetamine regulated transcript (CART), cholecystokinin (CCK), peptide YY (PYY) and orexin were isolated in red-bellied piranha and their mRNA tissue and brain distributions examined. When compared to other fish, the sequences obtained for all peptides were most similar to that of ...
Zhou Lin L State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China; The 88th Hospital of PLA, Tai'an, 271000, - - 2014
Prion protein (PrPc) has been previously reported to be involved in gastric cancer(GC) development and progression. However, the association between expression of PrPc and GC prognosis is yet poorly characterized. In the present study, the expressions of PrPc and MGr1-Ag/37LRP, a protein interacting with PrPc, were detected using the tissue ...
Flood Diana E K DE Department of Chemistry and Chemical Engineering, Royal Military College of Canada, ON, CA;and Biology Department, Queen's University, Kingston, ON, CA. Electronic address: - - 2014
The objectives of this study were to examine the effects of potassium perchlorate (KClO4) treatment on androgen- and thyroid hormone (TH)-related transcript levels during gonadogenesis in the frog Silurana tropicalis. Androgen- and TH-related gene expression was examined in gonad-mesonephros complex (GMC) and liver tissues at stage NF 56 and stage ...
Simões Priscila Santos Rodrigues PS Neurology/Neurosurgery Department, Federal University of São Paulo (UNIFESP), São Paulo, - - 2014
Thimet oligopeptidase (TOP) is a metalloprotease that has been associated with peptide processing in several nervous system structures, and its substrates include several peptides such as bradykinin, amyloid beta (Aβ), and major histocompatibility complex (MHC) class I molecules. As shown previously by our research group, patients with temporal lobe epilepsy ...
Fang Di-An DA Scientific Observing and Experimental Station of Fishery Resources and Environment in the Changjiang River, Freshwater Fisheries Research Center, Wuxi, Shanshui Road 9, 214081, - - 2014
Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2 in the presence of sulfhydryl compounds. In this study, a full length PGDS gene comprising 1250 nucleotides from the Chinese mitten crab Eriocheir sinensis (Es-PGDS) was characterized, with a 615bp open reading frame encoding 204 amino acid residues. ...
Mannerås-Holm Louise L Institute of Neuroscience and Physiology; Department of Physiology; Sahlgrenska Academy; University of Gothenburg; Gothenburg, - - 2014
Adipose tissue dysfunction may be a central factor in the pathogenesis of insulin resistance in women with polycystic ovary syndrome (PCOS). Gene expression in subcutaneous adipose tissue in PCOS and its relation to metabolic and endocrine features of the syndrome have been fragmentarily investigated. The aim was to assess in ...
Buckman Laura B LB Department of Molecular Physiology & Biophysics; Vanderbilt University Medical Center; Nashville, TN - - 2014
S100B is a calcium binding protein found in adipose tissue; however, relatively little is known about the physiologic regulation or distribution of the protein within this organ. We examined plasma S100B concentration and white adipose tissue (WAT) s100b mRNA levels in lean and diet-induced obese (DIO) mice. Plasma S100B levels ...
Jianmin Zou Z a Institute of Poultry Science , Chinese Academy of Agricultural Science , Yangzhou , - - 2014
The IGF system is one of the most important endocrine and paracrine growth factor systems that regulate fetal and placental growth, whereas the liver is the principal source of circulation IGF-I. In the present study, expression of IGF-I, IGF type-I receptor (IGF-IR), and IGF binding protein (IGFBP)-3 genes was quantified ...
Wang X X Department of Gynecology, Laiwu People's Hospital, 001 Xuehu avenue, Laiwu, 271100, China, - - 2014
The present study aimed to investigate the expression level of MicroRNA-25 (miR-25) in epithelial ovarian cancer (EOC) tissue, and examine its relationship with clinicopathological factors and prognosis of patients with EOC. Expression levels of miR-25 in 86 pairs of EOC tissue and adjacent normal tissue were measured by quantitative real-time ...
Samyesudhas Serene J SJ Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, South Bend, IN, USA. Electronic address: - - 2014
ARID3B is a DNA binding protein that is overexpressed in neuroblastoma and ovarian cancer. To understand the extent that ARID3B participates in tumor development, we assessed protein expression of ARID3B in normal adult and malignant tissues. We found that ARID3B is highly expressed in differentiated layers of squamous epithelium. We ...
Wang Tao T Department of Aquaculture, Sichuan Agricultural University, 46# Xinkang Road, Ya'an, 625014, - - 2014
Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. For a better understanding of the structure and function of the CRH gene and to study its effect on feeding regulation in cyprinid fish, the cDNA of the CRH gene from the brain of ...
Kanda Mitsuro M Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan, - - 2014
Patients with advanced gastric cancer (GC) have an adverse prognosis even after curative resection. Development of novel diagnostic and therapeutic approaches for GC is urgently required. The expression and methylation status of DENN/MADD domain-containing protein 2D (DENND2D), a member of the membrane trafficking proteins, were evaluated in 12 GC cell ...
Kanda Mitsuro M Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, - - 2014
The prognosis of advanced gastric cancer (GC) remains dismal. The aim of this study was to identify a novel tumor suppressor gene (TSG) with repressed transcription by aberrant DNA methylation in GC. The expression and methylation status of tumor suppressor candidate 1 (TUSC1) were evaluated in GC cell lines and ...
Wan Zhiyi Z State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, No.2 Yuan Ming Yuan West Road, Beijing, 100193, People's Republic of - - 2014
PRDM1 (PR domain containing 1) is a transcriptional repressor that has been identified in various species and is crucial for cell growth, differentiation and development. However, the expression pattern and role of PRDM1 in development has not been sufficiently established in birds. We therefore investigate the spatio-temporal expression of PRDM1 ...
Zhang Zhi-Wei ZW a Key Laboratory of Chicken Genetics and Breeding of Agriculture Ministry, Key Laboratory of Animal Genetics, Breeding and Reproduction of Education Department of Heilongjiang Province , College of Animal Science and Technology, Northeast Agricultural University , Harbin , - - 2014
Studies in mammalian species showed that Krüppel-like factor 3 (KLF3) regulated adipose tissue development. However, it was not reported in chicken. In the current study, we found that during the growth and development of abdominal fat tissue, chicken KLF3 (Gallus gallus KLF3, gKLF3) was consecutively expressed, and its transcripts were ...
Xu Xin-Hua XH Oncology Department, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, 183 Yiling Road, Yichang 443003, China. Tel. +86 (717) 6487360. Fax. +86 (717) 6481291. E-mail: - - 2014
Nasopharyngeal carcinoma (NPC) is a polygenic disease related to a variety of factors. With the development of the microRNAs (miRNAs) technique, researchers found a close link between miRNAs and NPC. Differentially expressed miRNAs exist in NPC and normal nasopharyngeal tissues; radiotherapy and chemotherapy also affect the expression of miRNAs in ...
Aso Teppei T From the Departments of *Surgery and Oncology, and †Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, - - 2014
Aberrant expression of several microRNAs (miRs) has been reported in various neoplasms including intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. MicroRNA-196a (miR-196a) is up-regulated in Barrett esophagus (characterized by intestinal metaplasia) and in colorectal cancer; this relationship between intestinal characteristics and miR-196a might also be applicable to intestinal-type IPMNs. ...
Abbott Sarah K - - 2014
Genetic studies have provided increasing evidence that ceramide homeostasis plays a role in neurodegenerative diseases including Parkinson’s disease (PD). It is known that the relative amounts of different ceramide molecular species, as defined by their fatty acyl chain length, regulate ceramide function in lipid membranes and in signaling pathways. In ...
Rogers Ryan P RP Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, 263 Farmington, CT 06030-6403, - - 2014
TheDrosophila Indy (I'm Not Dead Yet) gene encodes a plasma membrane transporter of Krebs cycle intermediates, with robust expression in tissues associated with metabolism. Reduced INDY alters metabolism and extends longevity in a manner similar to caloric restriction (CR); however, little is known about the tissue specific physiological effects of ...
Varelas Xaralabos X Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Room K-620, Boston, MA 02118, - - 2014
Studies over the past 20 years have defined the Hippo signaling pathway as a major regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have emerged, the majority of which in vertebrates are determined by the transcriptional regulators TAZ and YAP (TAZ/YAP). Key processes regulated by ...
Gauff Felicia C FC Department of Horses and Small Animals, University of Veterinary Medicine Vienna, A-1210 Vienna, - - 2014
Objective-To determine the effect of short-term hyperinsulinemia on the localization and expression of endothelin receptor (ETR)-A and ETR-B in lamellar tissue of the forelimbs of horses. Samples-Distal portion of 15 cadaveric forelimbs from healthy adult horses (1 limb/horse) obtained immediately after slaughter at an abattoir. Procedures-Each forelimb was assigned to ...
Yang Wen-Bing WB Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China, - - 2014
The abnormal expression of MUC15, a novel cell membrane-associated mucin, has been reported to predict poor survival in several cancers. The aim of the present study was to examine the expression of MUC15 in glioma and its correlation with clinicopathological features, including the survival of patients with glioma. The mRNA ...
Vassilakos George G Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, - - 2014
Insulin-like growth factor-1 (IGF-1) is a multipotent growth factor involved in the growth, development and regulation of homeostasis in a tissue-specific manner. Alternative splicing, multiple transcription initiation sites and different polyadelynation signals give rise to diverse mRNA isoforms, such as IGF-1Ea, IGF-1Eb and IGF-1Ec transcripts. There is increasing interest in ...
He Songbing S Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China; Washington University School of Medicine, St. Louis, Missouri 63110, USA. Electronic address: - - 2014
Cancer stem cells (CSCs) have been the focus of intense investigations in cancer research although the cellular origin of CSCs has not been clearly determined. Lgr5 is a regulated target of Wnt/β-catenin signaling, which was first identified as a marker of intestinal stem cells. However, the expression of Lgr5 in ...
Zheng Jiexing J Burn Center, Ruijin Hospital, Jiaotong University Medical School, Shanghai, - - 2014
The skin color of human hypertrophic scar changes dynamically during scar progression. To investigate whether hypoxia is dynamic during scar progression. Thirty-five patients with early, proliferative, regressive, and mature scars were involved in this study. Tissue oxygen tension was measured before scar surgery. After surgery, the scar stage was further ...
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