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Results 251 - 300 of 3016
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Vartak-Sharma Neha N University of North Texas Health Science Center, United - - 2014
Astrocyte Elevated Gene-1 (AEG-1), a novel HIV-1 and TNF-α inducible oncogene, has generated significant interest in the field of cancer research as a therapeutic target for many metastatic aggressive tumors. However, little is known about its role in astrocyte responses during HIV-1 CNS infection, and whether it contributes towards the ...
Anderson Eve E MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, - - 2014
The regulatory architecture that controls developmental genes is often a collection of enhancers that, in combination, generate a complex spatial and temporal pattern of expression. These enhancers populate domains operating at long distances and, in the case of the sonic hedgehog (Shh) locus, this regulatory domain covers ∼900-1000kb. Within this ...
Teramatsu Yoko Y Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, - - 2014
Repair of damaged periodontal ligament (PDL) tissue is an essential challenge in tooth preservation. Various researchers have attempted to develop efficient therapies for healing and regenerating PDL tissue based on tissue engineering methods focused on targeting signaling molecules in PDL stem cells and other mesenchymal stem cells. In this context, ...
Kang Min-Ju MJ Laboratory of Genetics, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, - - 2014
The primarily neuronal RNA-binding protein HuD is implicated in learning and memory. Here, we report the identification of several HuD target transcripts linked to Alzheimer's disease (AD) pathogenesis. HuD interacted with the 3' UTRs of APP mRNA (encoding amyloid precursor protein) and BACE1 mRNA (encoding β-site APP-cleaving enzyme 1) and ...
Cho Sun Wook SW Department of Internal Medicine, Seoul National University College of Medicine, Seoul, - - 2014
Backgrounds: Aberrant activation of the Wnt/β-catenin pathway is a common pathogenesis of various human cancers. We investigated the role of Wnt inhibitor, Dkk-1, in papillary thyroid cancer (PTC). Methods: Immunohistochemical β-catenin staining was performed in tissue microarray containing 148 papillary thyroid cancers (PTC) and 5 normal thyroid tissues. In vivo ...
Shih D Q DQ F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, - - 2014
Intestinal fibrostenosis is among the hallmarks of severe Crohn's disease. Patients with certain TNFSF15 (gene name for TL1A) variants over-express TL1A and have a higher risk of developing strictures in the small intestine. In addition, sustained Tl1a expression in mice leads to small and large intestinal fibrostenosis under colitogenic conditions. ...
Catalán Victoria V Metabolic Research Laboratory (V.C., J.G.-A., A.R., A.I.P.-H., J.G., B.R., L.M.-G., G.F.), Departments of Surgery (F.R., V.V., P.M.), Anesthesia (R.M.), Pathology (I.S.) and Endocrinology & Nutrition (C.S., J.S., G.F.), Clínica Universidad de Navarra, Pamplona, Spain. CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Spain (V.C., J.G.-A., A.R., B.R., F.R., V.V., C.S., J.S., - - 2014
Context: Wingless-type MMTV integration site family (WNT)-5A is a glycoprotein involved in the regulation of the inflammatory response by activating the non-canonical Wnt signaling pathway. Secreted frizzled-related protein (SFRP)-5 acts as a decoy receptor that binds and sequesters WNT5A, preventing activation of frizzled receptors and attenuating the non-canonical Wnt signaling. ...
Yuan Dengyue D Department of aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, - - 2014
In the present study, full-length cDNA sequences of leptin and cholecystokinin (CCK) were cloned from Schizothorax prenanti (S. prenanti), and applied real-time quantitative PCR to characterize the tissue distribution, and appetite regulatory effects of leptin and CCK in S. prenanti. The S. prenanti leptin and CCK full-length cDNA sequences were ...
Tretiakova Maria S MS Department of Pathology, University of Washington, Seattle, WA, - - 2014
Owing to the loss of heterochromatin integrity that occurs during thyroid tumorigenesis, the expression of Heterochromatin Protein 1 isoforms HP1α and HP1β was assessed by immunohistochemistry in 189 thyroid tumors and non-neoplastic tissues. Expression of HP1β was significantly decreased in all thyroid lesions, except in follicular adenomas, when compared with ...
Xing Y U - - 2014
MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs, which are involved in carcinogenesis. Laryngeal squamous cell carcinoma (LSCC) represents the largest subgroup of squamous cell carcinoma in head and neck. Whether miRNAs can be used in the diagnosis of LSCC is largely unknown. The aim of this study was to identify ...
Beyer Nancy N Queen's University Belfast, School of Medicine, Dentistry and Biomedical Sciences, N. - - 2014
β-site amyloid precursor protein cleaving enzyme (BACE1) is the rate-limiting enzyme for production of Aβ peptides, proposed to drive the pathological changes found in Alzheimer's disease (AD). Reticulon 3 (RTN3) is a negative modulator of BACE1 (β-secretase) proteolytic activity, while peptidylprolyl isomerase (cyclophilin)-like 2 (PPIL2) positively regulated BACE1 gene expression ...
Majkut Stephanie S Biophysical Engineering Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA; Physics and Astronomy Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, - - 2014
Early in embryogenesis, the heart begins its rhythmic contractions as a tube that helps perfuse the nascent vasculature, but the embryonic heart soon changes shape and mechanical properties, like many other developing organs. A key question in the field is whether stresses in development impact the underlying gene circuits and, ...
Di Fiore Maria Maddalena MM Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università di Napoli, via Vivaldi 43, 80100, Caserta, Italy, - - 2014
Free D-aspartate (D-Asp) occurs in substantial amounts in glandular tissues. This paper reviews the existing work on D-Asp in vertebrate exocrine and endocrine glands, with emphasis on functional roles. Endogenous D-Asp was detected in salivary glands. High D-Asp levels in the parotid gland during development suggest an involvement of the ...
Arzt Lisa L Institute of Pathology, Research Unit for Molecular Lung- and Pleurapathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria, - - 2014
Malignant pleural mesothelioma (MPM) is the most common primary tumor of the pleura. Its incidence is increasing in Europe and the prognosis remains poor. We compared epithelioid MPM in short and long survivors, and identified signal transducer and activator of transcription 1 (STAT1) as probably being responsible for antiapoptotic signaling ...
To Sarah Q SQ Cancer Drug Discovery Laboratory, MIMR-PHI Institute of Medical Research, Clayton, Victoria 3168, Australia; Monash University, Clayton, Victoria 3168, - - 2014
Aromatase is the critical enzyme that converts androgens to estrogens. It is frequently highly expressed in the tumour bearing breast of women diagnosed with estrogen receptor positive tumours, resulting in dramatically increased local estrogen production to drive tumour progression. Expression of aromatase is regulated primarily at the transcriptional level of ...
Yao Fuli F School of Life Science and Technology, University of Electronic Science and Technology of China, No. 4, Section 2, North Jianshe Road, Chengdu 610054, Sichuan, People's Republic of - - 2014
The Runt-related transcription factor (Runx) family consists of three members, Runx1, Runx2 and Runx3 in mammals, which are involved in various biological processes. Recent studies have demonstrated that Runx1 plays critical roles in the immunity of higher vertebrates. In fish, zebrafish and fugu Runx family members have been identified, and ...
Beaman Glenda Maria GM School of Forensic and Investigative Sciences, University of Central Lancashire, Preston, PR1 2HE, - - 2014
Production of heat shock protein 70 (HSP70/HSPA) is induced by a wide range of cellular stress conditions, such as cancer and hypoxia, with production also being linked to tumourigenesis. HSPA mRNA transcripts and proteins were examined in three human glioma cell lines, representing astrocytoma, oligodendroglioma and glioblastoma, plus 18 clinical ...
Zhang Junli J Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. - - 2014
Jagged2 is closely associated with numerous congenital diseases and has an important role in multiple malignancies. It has been identified that Jagged2 is a sonic hedgehog‑regulated factor. However, its expression and correlation with Gli1 in hepatocellular carcinoma (HCC) remain unknown. A total of 58 samples of surgically resected paired HCC and normal ...
Cai Jingjing - - 2014
Previous reports have indicated that matrix metallopeptidase2 (MMP-2) regulates angiogenic processes, which are involved in choroidal neovascularization (CNV). However, the regulation of MMP-2 in CNV has not been well-characterized. To gain more information about the regulation of MMP-2 in CNV, we analyzed the circuitry associated with MMP-2 regulation in a ...
Lasarzik Irina I Johannes Gutenberg-University, Department of Anesthesiology, Mainz, Germany ; - - 2014
Tissue sampling for gene expression analysis is usually performed under general anesthesia. Anesthetics are known to modulate hemodynamics, receptor-mediated signaling cascades and outcome parameters. The present study determined the influence of anesthetic paradigms typically used for euthanization and tissue sampling on cerebral mRNA expression in mice. Naïve mice and animals ...
Zhou Bin B Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. - - 2014
N‑myc downstream regulated gene 2 (NDRG2) is highly expressed in numerous normal tissues, while it is marginally expressed or undetectable in various tumors, including lung and colon cancer. In order to investigate the expression of NDRG2 in human glioma and its downstream regulatory mechanisms, quantitative polymerase chain reaction (qPCR), immunohistochemistry and ...
Cocci Paolo P School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III Da Varano, I-62032 Camerino, MC, - - 2014
Epigallocatechin gallate (EGCG), the major active component of the green tea, has recently been found to inhibit 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCoAR) activity in vitro and to modulate lipogenesis in vivo. In this study we have evaluated the effects of short-term in vivo exposure to EGCG (6μgg(-1) BW or 9μgg(-1) BW) on ...
Lappas Martha M M Lappas, Department of Obstetrics & Gynaecology, University of Melbourne, HEIDELBERG, 3084, Australia - - 2014
Maternal peripheral insulin resistance and increased inflammation are two features of pregnancies complicated by gestational diabetes mellitus (GDM). The nucleotide oligomerization domain (NOD) intracellular molecules recognise a wide range of microbial products as well as other intracellular danger signals, thereby initiating inflammation through activation of nuclear factor-κB. The aim of ...
Hu Guo-Bin GB Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China; College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China. Electronic address: - - 2014
Interferon regulatory factor 9 (IRF9) in mammals is known to be involved in antiviral response. In this study, we studied the structure, mRNA tissue distribution and regulation of IRF9 from Japanese flounder, Paralichthys olivaceus. The cDNA sequence of IRF9 is 3305 bp long, containing an open reading frame (ORF) of ...
Vartoukian Sonia R SR Centre for Clinical and Diagnostic Oral Sciences, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, London, - - 2014
The Suppressor-of-Cytokine-Signalling-3 (SOCS3) negatively regulates the JAK/STAT3/IL-17 pathway. The pro-inflammatory cytokine IL-17 is overexpressed in Sjögren's syndrome (SS) and is a key factor in its pathogenesis. We hypothesised that IL-17 overexpression in SS results from ineffective regulation by SOCS3. The expression of SOCS3 was analysed in peripheral-blood mononuclear cells (PBMC) ...
Huang Guian G Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, PR - - 2014
Leptin (LEP) is reported to play important roles in controlling energy balance in vertebrates including birds; however, it remains an open question whether an authentic 'leptin gene' exists and functions in birds. Here, we identified and characterized a leptin gene (zbLEP) encoding a 172-amino acid precursor in zebra finches. Despite ...
Liu C P CP Department of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China, - - 2014
Selenium (Se) is an essential trace element in many life forms due to its occurrence as selenocysteine (Sec) residue in selenoproteins. However, little is known about the expression pattern of selenoproteins in the liver of layer chicken. To investigate the effects of Se deficiency on the mRNA expressions of selenoproteins ...
Tulalamba Warut W Graduate Programme in Molecular Medicine, Mahidol University, Bangkok, - - 2014
Although the ERBB proteins have been shown to be associated in many types of human tumours and serve as important cancer therapeutic targets, however, data regarding the expression and clinical relevance of ERBBs in nasopharyngeal carcinoma (NPC) are still conflicting. The aim of this study is to investigate the expression ...
Bogefors Jesper J Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Skånes University Hospital, Lund University, Malmö, - - 2014
In the upper airway, the production of antimicrobial peptides (AMPs) protects against bacteria, viruses and fungi. Previous investigations have revealed downregulated expression of AMPs in different manifestations of allergic disease. In this study, we examined the expression of LL-37, RNase7 and LEAP-2 in tonsillar tissue and studied a possible relation ...
Gunasekaran Vinoth Prasanna VP Department of Biomedical Science, School of Basic Medical Sciences, Bharathidasan University, Tiruchirappalli, India, 620024. Electronic address: - - 2014
The detection of possible correlation between ribosomal protein RPS27A and multifunctional YB-1 expression in Hepatocellular carcinoma (HCC). Tissue microarray slides containing totally 80 cores with 19 tissues of HCC, 1 tissue of hepatocholangiocarcinoma, 10 tissues of liver cirrhosis and 10 normal liver tissues in duplicates were analyzed for expression of ...
Yilmaz Mehmet M Department of Otorhinolaryngology, Cerrahpasa Medical School, Istanbul University, Istanbul, - - 2014
Background: Laryngeal squamous cell carcinoma (LSCC), being an aggressive malignancy, is one of the most commonly diagnosed malignant types of head and neck squamous cell carcinoma worldwide. The recent studies suggested that αB-Crystallin might play an important role in tumorigenesis. In this study, we aimed to investigate the αB-Crystallin expression ...
Breves Jason P JP Hawaii Institute of Marine Biology, University of Hawaii, Kaneohe, HI 96744, USA; Department of Biology & Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: - - 2014
Growth in teleosts is controlled in large part by the activities of the growth hormone (Gh)/insulin-like growth factor (Igf) system. In this study, we initially identified igf-binding protein (bp)1b, -2b, -4, -5a and -6b transcripts in a tilapia EST library. In Mozambique tilapia (Oreochromis mossambicus), tissue expression profiling of igfbps ...
Lin Xiao-Cong XC Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing 400016, P.R. - - 2014
Long non-coding RNAs (lncRNAs) have been shown to play a critical role in cancer biology and are frequently aberrantly expressed. Despite their important role in pathology, little is known mechanistically regarding their role in gastric cancer (GC) pathogenesis. To characterize the role of lncRNAs in GC pathogenesis, 8 paired human ...
Qiu Dong-Mei - - 2014
A role for autophagy, a conserved cellular response to stress, has recently been demonstrated in human cancers. Aberrant expression of Beclin-1, an important autophagic gene, has been reported in various human cancers. In the present study, we investigated the significance and relationship between Beclin-1 expression and cell proliferation, apoptosis, microvessel ...
Khvostova E P EP Institute of Molecular Biology and Biophysics, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, - - 2014
Benign prostatic hyperplasia (BPH) as well as prostate cancer (CaP) are prevalent in the aging male population, and both the diseases display androgen-dependence when the circulating testosterone from the gonads decreases. This suggests that the local or intracrine production of androgens may drive these diseases. Both diseases are dependent on ...
Leppert Ulrike U Charité - Universitätsmedizin Berlin, Campus Mitte, 10117, Berlin, - - 2014
Tissue Factor (TF) is an evolutionary conserved glycoprotein, which is of immense importance for a variety of biologic processes. TF is expressed in two naturally occurring protein isoforms, membrane-bound "full-length" (fl)TF and soluble alternatively spliced (as)TF. The TF isoform expression is differentially modulated on post-transcriptional level via regulatory factors, such ...
Liu Tielong T Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. - - 2014
Osteosarcoma is the most common type of human primary malignant bone tumor with a potential propensity for local invasion and distant metastasis. Thus, this study focused on the expression and roles of IRX2 in the development of osteosarcoma. The mRNA expression levels of IRX2 in tissue samples of 69 cases of ...
Agaimy Abbas A Institute of Pathology, University Hospital Erlangen, Erlangen, - - 2014
Sinonasal hemangiopericytoma (SN-HPC) is a rare sinonasal mesenchymal neoplasm of perivascular myoid cell origin. Solitary fibrous tumor (SFT) occurs only very rarely in the sinonasal tract. SFT and soft tissue HPC were considered a single entity. Recently, recurrent gene fusions involving NAB2/STAT6 resulting in differential expression of STAT6 were characterized ...
Chu Dinh-Toi DT From the Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-748 Olsztyn, - - 2014
A cohort of genes was selected to characterize the adipogenic phenotype in primary cell cultures from three tissue sources. We compared the quantitative expression of biomarkers in culture relative to their expression in vivo because the mere presence or absence of expression is minimally informative. Although all biomarkers analyzed have ...
Morrison Jamie Ian JI Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrheniusväg 20C, Stockholm, 10691, Sweden, - - 2014
Transcription is the primary regulatory step to gene expression. However, there are numerous post-transcriptional mechanisms that are also crucial for developing the transcritptome, and the subsequent proteome, signature of any physiological setting. Organ and tissue regeneration is one such physiological setting that requires the rapid development of an environment that ...
Zhong Xinwen X Department of Thoracic Surgery, The First Affiliated Hospital, China Medical University, Shenyang, - - 2014
Histone methyltransferase G9a has been primarily understood as a co-repressor of gene expression, but it has been showed G9a also positively regulates nuclear receptor mediated transcription. MCM7, a critical component of the DNA replication licensing complex, is amplified and over-expressed in a variety of human malignancy. The objectives of the ...
Harstad Sara L SL Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic, 200 First Street SW, 5-194 Joseph Building, Rochester, MN 55905, United States. Electronic address: - - 2014
Pregnancy-associated plasma protein-A (PAPP-A) is a novel zinc metalloproteinase that functions in many systems outside of pregnancy. Data in both humans and mice suggest a role for PAPP-A in aging and age-related diseases. However, our knowledge of tissue-specific PAPP-A expression and possible changes in this expression with age is limited. ...
Zhang Ke K Department of Hepatobiliary Surgery, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Beijing, 100015, - - 2014
CYP2W1 overexpression has been reported in a variety of human cancers. However, the role of CYP2W1 in hepatocellular carcinoma (HCC) remains unclear. This study was designed to evaluate the expression and prognostic significance of CYP2W1 in human HCC. Real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was conducted to detect CYP2W1 ...
Chen Paula P Department of Animal Sciences, The Ohio State University, Columbus - - 2014
The United States is a world leader in poultry production, which is the reason why achieving better performance and muscle growth each year is a necessity. Reducing accretion of adipose tissue is another important factor for poultry producers because this allows more nutrients to be directed toward muscle growth, but ...
Assefnia Shahin S Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Research Building, Room 520A, Washington, District of Columbia 20057, USA Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive, Bethesda, Maryland 20892-0822, USA Department of Microbiology, Dankook University, Cheonan 330-714, Republic of Korea Department Pharmazie, Ludwig-Maximilians-Universität München, München, Germany College of Medical Sciences, King Khalid University, Abha, Saudi Arabia Departments of Pathology Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Research Building, Room 520A, Washington, District of Columbia 20057 - - 2014
Transformation-related protein 63 (Trp63), the predominant member of the Trp53 family, contributes to epithelial differentiation and is expressed in breast neoplasia. Trp63 features two distinct promoters yielding specific mRNAs encoding two major TRP63 isoforms, a transactivating transcription factor and a dominant negative isoform. Specific TRP63 isoforms are linked to cell ...
Urias Ursula U Laboratory of Molecular and Cellular Biology, Department of Neurology, Faculdade de Medicina da, Universidade de São Paulo, São Paulo, SP, 01246-903, - - 2014
In the present study, we searched for genes highly expressed in placenta and that could contribute to the establishment and maintenance of a malignant phenotype in different types of tumours, and in astrocytomas in particular. We employed a strategy based on the integration of in silico data from previously generated ...
Parker M Rockwell MR Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19103 United States. Electronic address: - - 2014
Stress increases the secretion of glucocorticoids (GCs), potent steroid hormones that exert their effects on numerous target tissues by acting through glucocorticoid receptors (GRs). GC signaling significantly affects ingestive behavior and taste preferences in humans and rodent models, but far less is known about the hormonal modulation of the peripheral ...
Gao Yankun Y Department of Biological Sciences, University at Buffalo, Buffalo, NY 14260, - - 2014
Despite the importance of taste in determining nutrient intake, our understanding of the processes that control the development of the peripheral taste system is lacking. Several early regulators of taste development have been identified, including sonic hedgehog, bone morphogenetic protein 4 and multiple members of the Wnt/β-catenin signaling pathway. However, ...
Koh Winston W Departments of Bioengineering - - 2014
Circulating cell-free RNA in the blood provides a potential window into the health, phenotype, and developmental programs of a variety of human organs. We used high-throughput methods of RNA analysis such as microarrays and next-generation sequencing to characterize the global landscape circulating RNA in a cohort of human subjects. By ...
Li Wei W National & Regional United Engineering Laboratory of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Department of Orthopedic Surgery, Affiliated Hospital of Bengbu Medical College, Bengbu 233030, Anhui Province, - - 2014
Chondrosarcoma is the second most common type of primary bone malignancy following up osteosarcoma, characterized by resistance to conventional chemotherapeutic agents and radiation regimens. The p160 family members steroid receptor coactivator-1 and -3 (SRC-1 and SRC-3) have been implied in the regulation of cancer growth, migration, invasion, metastasis and chemotherapeutic ...
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