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Park Jae Hyung JH Division of Cardiology, Yonsei University Health System, Seoul, - - 2014
It has been known that the dominant driver of atrial fibrillation (AF) exists in the left atrium (LA) and the incidence of systemic thromboembolism is higher than that of pulmonary thromboembolism in patients with AF. Therefore, we hypothesized that histological and biochemical characteristics of the LA and the right atrium ...
Song Yan-Yan YY Department of Pathology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. - - 2014
Vasculogenic mimicry (VM) formation is important for invasion and metastasis of tumor cells in gastric adenocarcinoma (GAC). The present study aimed to investigate the association between signal transducer and activator of transcription-3 (STAT3), phosphor-STAT3 (p-STAT3), hypoxia-inducible factor-1α (HIF-1α) and VM formation in GAC, and discuss their clinical significance and correlation ...
Li Juan J Institute of Technical Biology and Agriculture Engineering, Chinese Academy of Sciences, Hefei, 230031, - - 2014
A novel rice constitutive promoter (P OsCon1 ) was isolated. The molecular mechanism of the promoter activity was investigated. P OsCon1 could be used as an alternative constitutive promoter for crop transgenic engineering. Monocot constitutive promoter is an important resource for crop transgenic engineering. In this report, we isolated a ...
Park Mi-Young MY Department of Food & Nutrition Education, Graduate School of Education, Soonchunhyang University, Asan, Chungnam 336-745, - - 2014
Carnosic acid (CA), found in rosemary (Rosemarinus officinalis) leaves, is known to exhibit anti-obesity and anti-inflammatory activities. However, whether its anti-inflammatory potency can contribute to the amelioration of obesity has not been elucidated. The aim of the current study was to investigate the effect of CA on Toll-like receptor 4 ...
Poynton Helen C HC School for the Environment, University of Massachusetts Boston, 100 Morrissey Blvd., Boston, MA 02125, United States. Electronic address: - - 2014
Marine biomonitoring programs in the U.S. and Europe have historically relied on monitoring tissue concentrations of bivalves to monitor contaminant levels and ecosystem health. By integrating 'omic methods with these tissue residue approaches we can uncover mechanistic insight to link tissue concentrations to potential toxic effects. In an effort to ...
Chagas Luciene Reginato LR Instituto de Pesquisa e Desenvolvimento - IP&D, Universidade do Vale do Paraíba - UNIVAP, Av. Shishima Hifumi, 2911. Urbanova, CEP 12244-000, São José dos Campos, SP, - - 2014
The increase in PGE2 production by microsomal PGE synthase-1 (mPGES-1) in CNS contributes to the severity of the inflammatory and pain responses in the model of edema formation and hyperalgesia induced by carrageenan. PGI2, alike to PGE2, plays an important role in the inflammation. Low-level laser therapy (LLLT) has been ...
Ferrante Maria C MC Department of Veterinary Medicine and Animal Productions, Federico II University of Naples, Via Delpino 1, 80137 Naples, - - 2014
Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) are highly lipophilic environmental contaminants that accumulate in lipid-rich tissues, such as adipose tissue. Here, we reported the effects induced by PCBs 101, 153 and 180, three of the six NDL-PCBs defined as indicators, on mature 3T3-L1 adipocytes. We observed an increase in lipid content, in ...
Chen M-K MK Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, - - 2014
It has been suggested that the p300 transcriptional coactivator participates in the regulation of a wide range of cell biological processes, and mutations in p300 have been identified in various cancers. The aim of the current study was to investigate p300 expression in Cutaneous squamous cell carcinoma (cSCC) tissues and ...
Lv Guixiang G Beijing Institute of Radiation Medicine, Beijing 100850, P.R. - - 2014
Accumulating evidence suggests that microRNAs (miRNAs) can function as oncogenes or as tumor suppressor genes depending on the tissue type or target. Therefore, clarification of the specific roles of miRNAs is vital for the diagnosis and treatment of cancer. In the present study, miR-451 was found to be downregulated in ...
Tao Ji J Department of Medical Oncology, the Affiliated Tumor Hospital, Harbin Medical University, Harbin, - - 2014
Mel-18 is a member of the polycomb group (PcG) of proteins, which are chromatin regulatory factors that play an important role in oncogenesis. This study was designed to investigate the clinical and prognostic significance of Mel-18 in colorectal cancer (CRC) patients. For this purpose, expression of Mel-18 mRNA was evaluated ...
Xu Shi-Hong - - 2014
The purpose of the present study was to examine the expression levels of microRNA-9 (miR-9) in osteosarcoma tissues and normal bone tissues, and investigate the relationships between miR-9 expression, clinicopathological features and the prognosis of patients with osteosarcoma. The expression levels of miR-9 in osteosarcoma tissues and corresponding non-cancerous tissues ...
Blirando K K University Pierre & Marie Curie Paris VI, Paris, - - 2014
The sarco(endo) plasmic reticulum Ca2+ ATPases (SERCA) system is a key regulator of calcium cycling and signaling in cardiac and vascular myocytes and is composed of several isoforms. We aimed to characterize 1) the expression of the different SERCA isoforms in normal mouse cardiovascular tissues and 2) the modulation of ...
Van Nieuwenhoven Fa F Cardiovascular Research Institute Maastricht (CARIM), Maastricht, - - 2014
A chronic increase in cardiac workload leads to hypertrophic growth of cardiomyocytes, often accompanied by accumulation of extracellular matrix (fibrosis). This structural remodeling of the myocardial wall impairs cardiac function and may eventually lead to heart failure. Connective Tissue Growth Factor (CTGF, CCN2) is considered to play an important role ...
Yin Xiaoming X Thyroid Research Unit, Department of - - 2014
Context: The immune response in autoimmune thyroid disease has been shown to occur primarily within the thyroid gland where the most abundant antigens can be found. A variety of capture molecules are known to be expressed by thyroid epithelial cells and serve to attract and help retain an intra-thyroidal immune ...
Guillomot M M INRA, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France. Electronic address: - - 2014
Alteration of expression of various genes including extracellular matrix components, have been suggested to play major role in the placental pathologies after somatic cloning in mammals. The objectives of the present study were to analyze pattern of expression (mRNA and protein) of the small leucine-rich proteoglycan, Decorin in association with ...
Levy Aviv - - 2014
The change from juvenile to mature phase in woody plants is often accompanied by a gradual loss of rooting ability, as well as by reduced microRNA (miR) 156 and increased miR172 expression. We characterized the population of miRNAs of Eucalyptus grandis and compared the gradual reduction in miR156 and increase ...
Warnefors Maria - - 2014
Mammalian microRNAs (miRNAs) are sometimes subject to adenosine-to-inosine RNA editing, which can lead to dramatic changes in miRNA target specificity or expression levels. However, although a few miRNAs are known to be edited at identical positions in human and mouse, the evolution of miRNA editing has not been investigated in ...
Eo Jungwoo J Pusan National University, Department of Biological Sciences, Busan, Korea, Republic of ; - - 2014
Endogenous retroviruses (ERVs), which are footprints of ancient germline infections, were inserted into the genome during the early stages of primate evolution. Human endogenous retroviruses (HERVs) occupy approximately 8% of the human genome. Although most ERV genes are defective, with large deletions, stop codons, and frameshifts in their open reading ...
Ruthenborg Robin J RJ Department of Molecular and Cell Biology, The University of Texas at Dallas, Richardson TX 75080, - - 2014
Wound healing is a complex multi-step process that requires spatial and temporal orchestration of cellular and non-cellular components. Hypoxia is one of the prominent microenvironmental factors in tissue injury and wound healing. Hypoxic responses, mainly mediated by a master transcription factor of oxygen homeostasis, hypoxiainducible factor-1 (HIF-1), have been shown ...
Juszczuk-Kubiak E E Department of Molecular Cytogenetics, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzębiec, Poland. Electronic address: - - 2014
The aim of this study was to analyze the level of expression of the Mef2C gene in the developing bovine longissimus dorsi (LD) muscle (at 6, 9 and 12months of age) and to evaluate differences in expression among Polish Holstein-Friesian (HO) and Limousine (LM) bulls. Moreover, the expression patterns of ...
Haselman Jonathan T JT US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Blvd. Duluth, MN 55804, USA. Electronic address: - - 2014
African clawed frog Xenopus sp. is used extensively for developmental biology and toxicology research. Amid concerns of environmental pollutants disrupting endocrine systems and causing altered reproductive development in wildlife, eco-toxicology research has led to a focus on linking molecular initiating events to population-level effects. As such, efforts to better understand ...
Di Jie-Hui JH Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, 84 West Huai-hai Road, Xuzhou, 221002, Jiangsu, People's Republic of - - 2014
The aim of our study was to elucidate the role of Rap2B in the development of human suprarenal epithelioma and to investigate the effect of Rap2B on suprarenal epithelioma cells migration and invasion. We use tissue microarray and immunohistochemistry to evaluate Rap2B staining in 75 suprarenal epithelioma tissues and 75 ...
He Hao-Lan HL Hao-Lan He, Qian Li, Department of Gastroenterology, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, - - 2014
To investigate the clinical significance of expression of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in ulcerative colitis (UC). Thirty UC specimens taken by colonoscopy from patients with active UC treated at the Department of Pathology, Central Hospital Affiliated to Shenyang Medical College from February 2010 to January ...
Amich Jorge J Instituto de Biología Funcional y Genómica (IBFG) (centro mixto CSIC-Universidad de Salamanca) y Departamento de Microbiología y Genética, Universidad de Salamanca, Edificio IBFG, Lab. P1.10. C/Zacarías González nº 2, 37007, Salamanca, - - 2014
Zinc is an essential micronutrient required for the growth of all microorganisms. To grow in the lungs of a susceptible patient Aspergillus fumigatus must obtain zinc from the surrounding tissues. The concentration of Zn(2+) ions in living tissues is much lower than that required for optimal fungal growth in vitro ...
Chwalisz Marina - - 2014
CYP19A1 encodes the aromatase which catalyzes the final reaction of estrogen biosynthesis. The bovine genome also contains a non-coding copy of CYP19A1, the transcribed pseudogene CYP19P1. Whereas CYP19A1 is transcribed in all estrogen-producing tissues, mainly in the placenta and gonads, the CYP19P1 transcript so far was detected in the placenta. ...
Chen Xi'en X Key Laboratory of Plant Protection Resources and Pest Management, Ministry of Education, College of Plant Protection, Northwest A & F University, Yangling, Shaanxi, - - 2015
We identify and characterize 14 small heat-shock protein (sHSP) genes from the diamondback moth (DBM), Plutella xylostella (L.), a destructive pest. Phylogenetic analyses indicate that, except for sHSP18.8 and sHSP19.22, the other 12 DBM sHSPs belong to five known insect sHSP groups. Developmental expression analysis revealed that most sHSPs peaked ...
Bodempudi Vidya V University of Minnesota School of - - 2014
Idiopathic Pulmonary Fibrosis is characterized by the relentless spread of fibroblasts from scarred alveoli into adjacent alveolar units resulting in progressive hypoxia and death by asphyxiation. Although hypoxia is a prominent clinical feature of IPF, the role of hypoxia as a driver of the progressive fibrotic nature of the disease ...
Seveso Davide D Department of Biotechnologies and Biosciences, University of Milan - Bicocca, Piazza della Scienza 2, 20126, Milan, Italy; MaRHE Centre (Marine Research and High Education Centre), Magoodhoo Island, Faafu Atoll, Maldives. Electronic address: - - 2014
Due to the increasing frequency and severity of the coral bleaching events in the context of global warming, there is an urgent need to improve our understanding of the susceptibility of corals to thermal stresses, particularly at the sub-cellular level. In this context, we examined the modulation of the polyp ...
Rubio-Moraga Angela - - 2014
In saffron (Crocus sativus), new corms develop at the base of every shoot developed from the maternal corm, a globular underground storage stem. Since the degree of bud sprouts influences the number and size of new corms, and strigolactones (SLs) suppress growth of pre-formed axillary bud, it was considered appropriate ...
Plaza David Fernando - - 2014
It is well known that mushrooms produce defense proteins and secondary metabolites against predators and competitors; however, less is known about the correlation between the tissue-specific expression and the target organism (antagonist) specificity of these molecules. In addition, conserved transcriptional circuitries involved in developing sexual organs in fungi are not ...
Eswarappa Sandeepa M SM Department of Cellular and Molecular Medicine, The Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, - - 2014
Translational readthrough, observed primarily in less complex organisms from viruses to Drosophila, expands the proteome by translating select transcripts beyond the canonical stop codon. Here, we show that vascular endothelial growth factor A (VEGFA) mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a ...
Groux-Degroote Sophie S Structural and Functional Glycobiology Unit, UMR CNRS 8576, University Lille Nord de France, Lille1, 59655 Villeneuve d'Ascq, - - 2014
The histo blood group carbohydrate Sd(a) antigen and its cognate biosynthetic enzyme B4GALNT2 show the highest level of expression in normal colon. Their dramatic down regulation previously observed in colon cancer tissues could play a role in the concomitant elevation of the selectin ligand sLe(x), involved in metastasis. However, down ...
Neeman Rina R Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel, - - 2014
Hepatic stellate cells (HSCs) have a key role in the formation of hepatic fibrosis. The active form of vitamin D, 1,25(OH)2D3, has been found to have antiproliferative and antifibrotic effects in various tissues including liver. Farnesylthiosalicylic acid (FTS), a novel Ras antagonist, was also found to inhibit hepatic fibrosis. The ...
Madsen Steffen S SS University of Southern Denmark, Denmark; - - 2014
We investigated the salinity dependent expression dynamics of 7 aquaporin paralogs (aqp1a, -3a, -7, -8ab, -10a, -10b and -11a) in several tissues of euryhaline Japanese medaka (Oryzias latipes). All paralogs except aqp7 and -10a had a broad tissue distribution and several were affected by salinity in both osmoregulatory and non-osmoregulatory ...
Bach Helene H Department of Psychiatry , Columbia University College of Physicians and Surgeons, New York, New York; Division of Molecular Imaging and Neuropathology , New York State Psychiatric Institute, New York, New - - 2014
Chronic alcohol use depletes brain serotonin (5-hydroxytryptamine [5-HT]), yet we previously found more tryptophan hydroxylase 2 (TPH2), the rate-limiting biosynthetic enzyme for 5-HT, in the dorsal raphe nucleus (DRN) of alcoholics. We sought to determine whether the increase in amount of TPH2 enzyme is associated with more TPH2 mRNA gene ...
Wu Hui-Mei HM Department of Pulmonary Medicine, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, PR - - 2014
Gene associated with retinoid and interferon-induced mortality 1 (GRIM-1) acts as a tumor growth suppressor via apoptosis induction. However, GRIM-1 expression in human non-small cell lung cancer (NSCLC) and its potential interaction with another apoptosis-associated protein-glucose-regulated protein 78 (GRP78)-are as yet unknown. Using 40 surgical specimens, we showed significantly lower ...
Taniguchi Yuka - - 2014
Appendage regeneration in amphibians is regulated by the combinatorial actions of signaling molecules. The requirement of molecules secreted from specific tissues is reflected by the observation that the whole process of regeneration can be inhibited if a certain tissue is removed from the amputated stump. Interestingly, urodeles and anurans show ...
Rasmussen Martin Krøyer MK Department of Food Science, Aarhus University, Denmark. Electronic address: - - 2014
Due to limited availability of human liver tissue for the study of cytochrome P450 (CYP450), porcine liver tissue has been suggested as an alternative source to prepare microsomes and hepatocytes. The porcine liver is made by four different lobes. The present study investigated the expression and activity of specific CYP450 ...
Dharmaraj N N Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251, - - 2014
Are the transmembrane mucins, MUC1, MUC4 and MUC16, differentially expressed in endometriosis compared with normal endometrium? This study revealed that transmembrane mucin expression does not vary significantly in normal endometrium during the menstrual cycle and is not altered in endometriosis relative to the epithelial marker, cytokeratin-18 (KRT18). Increased serum levels ...
Matsui Maiko M Department of Cell Biology, Duke University Medical Center, Durham, NC27710. Electronic address: - - 2014
Proper morphogenesis is essential for both form and function of the mammalian craniofacial skeleton, which consists of more than twenty small cartilages and bones. Skeletal elements that support the oral cavity are derived from cranial neural crest cells (NCCs) that develop in the maxillary and mandibular buds of pharyngeal arch ...
Shaikhibrahim Zaki Z Z Shaikhibrahim, Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Bonn, - - 2014
In a recent effort to unravel the molecular basis of prostate cancer, Barbieri and co-workers using whole-exome sequencing identified a novel recurrently mutated gene, MED12, in 5.4% of primary PCa. MED12, encoding a subunit of the Mediator complex, is a transducer of Wntcatenin signaling, linked to modulation of hedgehog signaling, ...
Fu Xiumin X Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Zijingang Campus, Hangzhou 310058, China South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, - - 2014
Differences in carotenoid accumulation between tissues and cultivars is common in plants. White-fleshed loquat cultivars had low levels of carotenoids in the flesh, but accumulated carotenoids in peel when ripe, and the leaves accumulated similar carotenoids to those in the red-fleshed loquat cultivars. The catalytic activity and expression patterns of ...
Zhen Tiantian T Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, - - 2014
Here we confirmed that metastasis-associated in colon cancer 1 (MACC1) and β-catenin expression were higher in colorectal cancer (CRC) cells and tissues than those in normal colonic epithelial cell line and adjacent non-tumour colorectal mucosa (ANM) tissues, respectively. MACC1 expression was significantly related to histological differentiation (p<0.001), UICC stage (p=0.029), ...
Peng Wei W Department of Digestive Diseases, Huashan Hospital, Fudan University, No. 12 Wulumuqi Road, Shanghai, 200040, - - 2014
The poor prognosis and high recurrent rate of pancreatic cancer (PC) necessitates the discovery of new predictive markers of PC invasion and prognosis. In this study, we evaluated the expression pattern of up-regulated gene 11 (URG11) in a tissue microarray with 18 pairs of PC and adjacent normal tissues. It ...
Wan Weiqing - - 2014
Malignant gliomas are the most common form of primary malignant brain tumor. It has recently been suggested that genetic changes are involved in the progression of malignant gliomas. In previous studies, a novel gene, p42.3, was characterized as a tumor-specific gene that encodes a mitosis phase-dependent expression protein which is ...
Massart Sophie S Research Unit in Environmental and Evolutionary Biology (URBE), NARILIS, University of Namur, Rue de Bruxelles, 61, B-5000 Namur, - - 2014
In vertebrates, estrogens act on the reproductive system but also affect the functioning of non-reproductive tissues such as the immune system. In teleost fish, effects of estrogens and xenoestrogens have been reported extensively, but the available information on targeted tissues and cells is still scarce. Moreover, a better knowledge of ...
Willi Martin M Section of Oral Translational Research, Institute of Oral Biology, Center of Dental Medicine, University of Zürich, - - 2014
Periodontitis is an inflammatory infectious disease that destroys the tooth-supporting tissues. It is caused by multi-species subgingival biofilms that colonize the tooth surface. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia (i.e. "red complex" bacteria) are characteristic subgingival biofilm species. The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a ...
Baltes Jennifer - - 2014
We describe altered sortilin sorting in AP-1/σ1B complex deficient adipocytes, which leads to the inhibition of adipogenesis. The AP-1 complex mediates protein sorting between the trans-Golgi network and endosomes. Vertebrates express three σ1-subunit isoforms: σ1A, σ1B and σ1C. σ1B -/- mice have impaired synaptic-vesicle recycling and a lipodystrophy. Sortilin is ...
Hardcastle M R MR Institute of Veterinary, Animal and Biomedical Sciences, College of Sciences, Massey University, Palmerston North, New - - 2014
Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of humans. Some mesenchymal tumours (often resembling haemangiopericytomas) express molecules that normally regulate phosphorus metabolism; most frequently, fibroblast growth factor 23. Patients develop renal phosphate wasting and inappropriately low serum concentrations of 1, 25 (OH)2 vitamin D3 , leading to osteomalacia. Surgical ...
Wallace Jacqueline J J Wallace, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, AB21 9SM, United Kingdom - - 2014
Intrauterine growth restriction (IUGR) is a risk factor for obesity, particularly when offspring are born into an unrestricted nutritional environment. Herein we investigated the impact of IUGR and gender on circulating lipids and on adipogenic, lipogenic and adipokine gene expression in perirenal adipose tissue. Singleton lambs born to overnourished adolescent ...
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