Search Results
Results 601 - 650 of 3003
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Guo Chaoshe - - 2014
Anorectal malformation (ARM) is a common birth defect but the developmental history and the underlying molecular mechanism are poorly understood. Using murine genetic models, we report here that a signaling molecule Dickkopf-1 (Dkk1) is a critical regulator. The anorectal and genitourinary tracts are major derivatives of caudal hindgut, or the ...
Jacques Jaime J Laboratory of Molecular Oral Pathophysiology, INSERM UMRS 1138, Team Berdal, Cordeliers Research Center, Pierre and Marie Curie University - Paris 6, Paris Descartes University - Paris 5, Paris, France; UFR d'Odontologie, Paris Diderot University - Paris 7, Paris, France; Unit of Periodontology, Department of Stomatology, University of Talca, Talca, - - 2014
Research on enamel matrix proteins (EMPs) is centered on understanding their role in enamel biomineralization and their bioactivity for tissue engineering. While therapeutic application of EMPs has been widely documented, their expression and biological function in non-enamel tissues is unclear. Our first aim was to screen for amelogenin (AMELX) and ...
Talbot Jared A JA Lewis-Sigler Institute for Integrative Genomics, Carl C. Icahn Laboratory, Princeton University, Princeton, NJ 08544, - - 2014
Dynamins are GTPases that are required for separation of vesicles from the plasma membrane and thus are key regulators of endocytosis in eukaryotic cells. This role for dynamin proteins is especially crucial for the proper function of neurons, where they ensure that synaptic vesicles and their neurotransmitter cargo are recycled ...
Zhang Ziyin - - 2014
Aims: Disabled-2 (Dab2) is frequently down-regulated in several types of cancers. We examined the expression level of Dab2 in human meningiomas and meningioma cells, aimed to investigate its role in the oncogenesis and development of meningiomas. Materials and Methods: Western blot analysis was employed to detect Dab2 expression in 90 ...
Diawara Malika R MR Institut National de la Santé et de la Recherche Médicale (INSERM) UMRS 872, Cordeliers Research Center, University Pierre & Marie Curie, Paris, France; Institute of Cardiometabolism & Nutrition, ICAN, Pitié-Salpêtrière Hospital, University Pierre & Marie-Curie, Paris, - - 2014
MicroRNAs are emerging as new mediators in the regulation of adipose tissue biology and the development of obesity. An important role of microRNA-125a has been suggested in the pathogenesis of insulin resistance (IR). Here, we characterized the function of microRNA-125a in adipose tissue in a context of experimentally-induced IR and ...
Huang Zhen Z Department of Gastrointestinal Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China E-mail : - - 2014
AMFR, autocrine motility factor receptor, also called gp78, is a cell surface cytokine receptor which has a dual role as an E3 ubiquitin ligase in endoplasmic reticulum-associated degradation. AMFR expression is associated with tumor malignancy. We here investigated the clinical significance of AMFR and its role in metastasis and prognosis ...
Zhao Qiu Q Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu, People's Republic of - - 2014
 Aims: To examine the relationship between the expression levels of miR-1 and PIK3CA in resected non-small-cell lung cancer (NSCLC) tissues and clinical characteristics and prognosis. Materials & methods: Levels of miR-1 and PIK3CA in cancerous and normal tissues obtained from 55 patients with NSCLC were measured by real-time PCR and ...
Cao Peng-Fei PF Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University Guangzhou, Guangdong, - - 2014
Hypertrophic scars are fibroproliferative disorders of excessive wound healing after skin injury. Vascular endothelial growth factor (VEGF)-induced angiogenesis plays a major role in fibrogenesis and hypertrophic scar formation. Over recent years, there has been a major interest in homeobox gene regulation of VEGF-VEGFR mediated angiogenesis in dermal tissue. In the ...
Matsui Sho S Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, - - 2014
Ultraviolet (UV) B irradiation decreases blood adiponectin levels, but the mechanism is not well understood. This study investigated how UVB irradiation reduces adiponectin expression in ovarial adipose tissues. Female Hos:HR-1 hairless mice were exposed to UVB (1.6 J/cm2) irradiation and were killed 24 h later. UVB irradiation decreased the adiponectin ...
Imanaka-Yoshida Kyoko K Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine Tsu, Japan ; Mie University Research Center for Matrix Biology Tsu, - - 2014
Living tissue is composed of cells and extracellular matrix (ECM). In the heart and blood vessels, which are constantly subjected to mechanical stress, ECM molecules form well-developed fibrous frameworks to maintain tissue structure. ECM is also important for biological signaling, which influences various cellular functions in embryonic development, and physiological/pathological ...
Zhang Di D Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University Shenyang, - - 2014
Delta-catenin, a member of the p120-catenin subfamily, and the Rho GTPase RhoA both have roles in the regulation of the cytoskeleton. In this study, we found that delta-catenin positive expression and RhoA over-expression is consistently found in non-small cell lung cancer, but not in normal lung tissue, and that their ...
Chen Guang-Lie GL School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu, PR ChinaE-mail : - - 2014
The STK15 gene located on chromosome 20q13.2 encodes a centrosome-associated kinase critical for regulated chromosome segregation and cytokinesis. Recent studies have demonstrated STK15 to be significantly associated with many tumors, with aberrant expression obseved in many human malignancies. The purpose of this study was to investigate expression of STK15 in ...
Wang Weilin W Key Laboratory of Health Ministry for Congenital Malformations, Shengjing Hospital of China Medical University 36 Sanhao Street Heping District, Shenyang, Liaoning, 110004, The People's Republic of - - 2014
Hirschsprung disease (HSCR) is characterized by the absence of intramural ganglion cells in the nerve plexuses of the distal gut. Recent studies have shown that the bone morphogenetic protein receptor-type IA (BMPR1α), actinin-alpha 4 (ACTN4α) and fatty acid binding protein 7 (FABP7) play important roles in the differentiation and development ...
Zhang Chun C Department of Orthopedic Surgery, The Second Hospital Affiliated to Xi'an Jiao Tong University School of Medicine Xi'an, Shaanxi, 710004, - - 2014
The aim of the present study was to investigate whether the aberrant expression of microRNA (miR)-133b and miR-206 can be used as potential prognostic markers of human osteosarcoma. Quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR) analysis was performed to detect the expression levels of miR-133b and miR-206 in 100 pairs ...
Haney Robert A - - 2014
Animal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries. Next-generation transcriptomics and proteomics provide unparalleled, but underexploited, capabilities for venom characterization. We combined multi-tissue RNA-Seq with mass spectrometry and bioinformatic analyses to determine venom gland specific transcripts and venom proteins from ...
Tiss Ali - - 2014
Obesity is characterized by a chronic low-grade inflammation and altered stress responses in key metabolic tissues. Impairment of heat shock response (HSR) has been already linked to diabetes and insulin resistance as reflected by decrease in heat shock proteins (HSPs) expression. However, the status of HSR in non-diabetic human obese ...
Martini Paolo P Department of Biology, University of Padova, Padova, Italy; CRIBI Biotechnology Centre, University of Padova, Padova, - - 2014
Despite the economic and medical importance of the pig, knowledge about its genome organization, gene expression regulation, and molecular mechanisms involved in physiological processes is far from that achieved for mouse and rat, the two most used model organisms in biomedical research. MicroRNAs (miRNAs) are a wide class of molecules ...
Jiang D F DF College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, - - 2014
Evodiamine, the major alkaloid component isolated from the fruit of dried, unripened Evodia rutaecarpa Bentham, affects the plasma levels of cholecystokinin and various biological events such as gastric emptying and gastrointestinal transit; these effects of evodiamine were previously investigated in male rats. In this study, we aimed to investigate the ...
Seo Sang Woo SW 1] Department of Bioengineering, University of California San Diego, La Jolla, California 92093-0412, USA - - 2014
The ferric uptake regulator (Fur) plays a critical role in the transcriptional regulation of iron metabolism. However, the full regulatory potential of Fur remains undefined. Here we comprehensively reconstruct the Fur transcriptional regulatory network in Escherichia coli K-12 MG1655 in response to iron availability using genome-wide measurements. Integrative data analysis ...
Wan Timothy Ming-Hun TM Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pok Fu Lam Road, Pok Fu Lam, Hong - - 2014
This study determined the expression of microRNA-133a (MiR-133a) in colorectal cancer (CRC) and adjacent normal mucosa samples and evaluated its clinicopathological role in CRC. The expression of miR-133a in 125 pairs of tissue samples was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) and correlated with patient's clinicopathological data by ...
Mesa Francisco F Department of Periodontics, School of Dentistry, University of Granada, Granada, - - 2014
The aim of this pilot study was to investigate associations between IL-6 and COX-2 expression in gingival biopsies and both clinical diagnosis and genotypes in the IL-6 and COX-2 genes. A case-control study included 41 gingival biopsies obtained from Caucasian patients grouped according to clinical diagnosis of gingival health (n = 10), ...
Wang Feng F Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China E-mail : - - 2014
Stathmin, also called oncoprotein 18, is a founding member of the family of microtubule-destabilizing proteins that play a critical role in the regulation of mitosis. At the same time stathmin has been recognized as one of responsible factors in cancer cells. The aim of this study was to assess stathmin ...
Patil Mallikarjun - - 2014
Id proteins (Id1-Id4) are helix-loop-helix (HLH) transcriptional regulators that lack a basic DNA binding domain. They act as negative regulators of basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibit their DNA binding and transcriptional activity. Id proteins areimplicated in the regulation of various cellular mechanisms such as cell ...
Liang Guanxiang G Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, - - 2014
This study aimed to investigate the potential regulatory role of miRNAs in the development of gastrointestinal tract (GIT) during the early life of dairy calves. Rumen and small intestinal (mid-jejunum and ileum) tissue samples were collected from newborn (30 min after birth; n = 3), 7-day-old (n = 6), 21-day-old (n = 6), and 42-day-old (n = 6) ...
Li Ying Y The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, - - 2014
Aim. To evaluate the predictive value of RRM1, ERCCl, and BRCA1 expression in Chinese NSCLC patients treated with gemcitabine and cisplatin. Methods. Real-time fluorescent quantitative PCR was used to determine the RRM1, ERCC1, and BRCA1 mRNA expression levels of peripheral blood in late-stage NSCLC patients. The relationship between peripheral blood ...
Kazmi Hasan Raza HR Department of Surgical Gastroenterology, King George's Medical University, Lucknow 226003, - - 2014
Background. Cholecystokinin type A receptor (CCKAR) is known to be overexpressed in variety of human malignancies but information regarding its expression in gallbladder cancer (GBC) is limited. Attempts were now made to investigate expression pattern of CCKAR mRNA and protein in controls and GBC patients and correlate it with various ...
Liu S X SX Key Laboratory for Ecological Environment in Coastal Areas, State Oceanic Administration, National Marine Environmental Monitoring Center, Dalian, - - 2014
Pattern recognition molecules play an important role in innate immunity by recognizing conserved molecular patterns that are present on the surface of invading microorganisms. In this study, a lipopolysaccharide and β-1,3-glucan binding protein (LGBP) gene was cloned from the hard clam Meretrix meretrix (designated as Mm-LGBP) by the expressed sequence ...
Tørring Pernille M PM Department of Clinical Genetics, Odense University Hospital, Odense, Denmark; Otorhinolaryngology, Institute of Clinical Research, University of Southern Denmark, Odense, - - 2014
Hereditary Haemorrhagic Telangiectasia (HHT) is an autosomal dominantly inherited vascular disease characterized by the presence of mucocutaneous telangiectasia and arteriovenous malformations in visceral organs. HHT is predominantly caused by mutations in ENG and ACVRL1, which both belong to the TGF-β signalling pathway. The exact mechanism of how haploinsufficiency of ENG ...
Wang Mingxia M School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China ; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China ; Department of Rheumatology of Zhongshan Affiliated Hospital, Sun Yat-Sen University, Zhongshan, Guangdong 528400, - - 2014
Sonic hedgehog (Shh) signaling controls many aspects of human development, regulates cell growth and differentiation in adult tissues, and is activated in a number of malignancies. Rheumatoid arthritis (RA) is characterized by chronic synovitis and pannus formation associated with activation of fibroblast-like synoviocytes (FLS). We investigated whether Shh signaling plays ...
Kozhemyakina Elena E Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of - - 2014
In the limb bud, patterning along the anterior-posterior (A-P) axis is controlled by Sonic Hedgehog (Shh), a signaling molecule secreted by the "Zone of Polarizing Activity", an organizer tissue located in the posterior margin of the limb bud. We have found that the transcription factors GATA4 and GATA6, which are ...
Gao Y - - 2014
Distal-less homeobox gene 4 (DLX4) has been shown to play a role in carcinogenesis. The value of DLX4 in hepatocellular carcinoma (HCC) has not been fully investigated. Here, we sought to quantify the expression of DLX4 in association with the clinicopathological features and prognosis in hepatocellular carcinoma (HCC). We examined ...
Liu Dongdong D State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang West Road, Guangzhou, Guangdong 510120, China ; Intensive Care Unit, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, - - 2014
Acute respiratory distress syndrome (ARDS) remains a high morbidity and mortality disease entity in critically ill patients, despite decades of numerous investigations into its pathogenesis. To obtain global protein expression changes in acute lung injury (ALI) lung tissues, we employed a high-throughput proteomics method to identify key components which may ...
Zhao Xin X Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, People's Republic of - - 2014
The purpose of this study was to investigate differentially expressed long noncoding RNAs (lncRNAs) in pulmonary adenocarcinoma tissue and adjacent noncancerous tissue from Chinese patients using lncRNA expression microarray and preliminary analysis. RNA extracted from three paired pulmonary adenocarcinoma tissue and adjacent noncancerous tissue specimens was used to synthesize double-stranded ...
Liszka L L Łukasz Liszka MD Department of Pathomorphology in Katowice Medical University of Silesia Medyków 18 40-754 Katowice, Poland tel./fax +48 32 25 25 080 e-mail: - - 2014
There are limited data on the biology of metastatic pancreatic ductal adenocarcinoma (PDAC). The aim of the present study was to compare the expression of immunohistochemical markers that may be involved in the development of metastatic disease in primary PDAC and in synchronous liver metastatic tissues. Thirty-two stains (corresponding to ...
Moreira Fabiano Cordeiro FC Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, - - 2014
MicroRNAs are small non-coding nucleotide sequences that regulate gene expression. These structures are fundamental to several biological processes, including cell proliferation, development, differentiation and apoptosis. Identifying the expression profile of microRNAs in healthy human gastric antrum mucosa may help elucidate the miRNA regulatory mechanisms of the human stomach. A small ...
Yu Yaping - - 2014
Previous studies have shown that lactate dehydrogenase-A (LDH-A) is strongly expressed in several malignancies, that LDH-A expression is associated with poor prognosis, and that LDH-A inhibition severely diminishes tumorigenicity. However, little is known about the implications of LDH-A expression in intrahepatic cholangiocarcinoma. The purpose of this study was to investigate ...
Yang Wen-Ting WT Department of Reproductive Medicine, First Affiliated Hospital Medical School of Xi'an Jiaotong University, Xi'an, The People's Republic of China ; Department of Biochemistry and Molecular Biology, Medical School of Xi'an Jiaotong University, Xi'an, The People's Republic of - - 2014
The KLF4 gene has been shown to be inactivated in cervical carcinogenesis as a tumor suppressor. However, the mechanism of KLF4 silencing in cervical carcinomas has not yet been identified. DNA methylation plays a key role in stable suppression of gene expression. The methylation status of the KLF4 promoter CpG ...
Wu Yu Y Department of Gynecology and Obstetrics, Qilu Hospital, Shandong University, Jinan, China E-mail : - - 2014
Objective: The tumor suppressor gene, Ras-association domain family (RASSF)2A, is inactivated by promoter hypermethylation in many cancers. The current study was performed to evaluate the methylation status of RASSF2A in epithelial ovarian cancer (EOC) tissues and plasma, and correlations with gene expression and clinicopathologic characteristics. Method: We detected methylation of ...
Nome Torfinn T Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital - Oslo University Hospital, Oslo, Norway; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, - - 2014
VTI1A-TCF7L2 was reported as a recurrent fusion gene in colorectal cancer (CRC), found to be expressed in three out of 97 primary cancers, and one cell line, NCI-H508, where a genomic deletion joins the two genes [1]. To investigate this fusion further, we analyzed high-throughput DNA and RNA sequencing data ...
Wang Hongwei H Advanced Cell Diagnostics, - - 2014
The 'gold standard' for oncogenic HPV detection is the demonstration of transcriptionally active high-risk HPV in tumor tissue. However, detection of E6/E7 mRNA by quantitative reverse transcription polymerase chain reaction (qRT-PCR) requires RNA extraction which destroys the tumor tissue context critical for morphological correlation and has been difficult to be ...
Kirkby Nicholas S NS National Heart & Lung Institute, Imperial College London, London, United Kingdom; The William Harvey Research Institute, Barts & the London School of Medicine & Dentistry, Queen Mary University of London, London, United - - 2014
Cyxlo-oxygenase (COX)-2 inhibitors, including traditional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with increased cardiovascular side effects, including myocardial infarction. We and others have shown that COX-1 and not COX-2 drives vascular prostacyclin in the healthy cardiovascular system, re-opening the question of how COX-2 might regulate cardiovascular health. In diseased, atherosclerotic ...
Guo Zhiyun Z School of Life Sciences and Bioengineering, Southwest Jiaotong University, Chengdu, 610031, P.R. - - 2014
Tissue-specific miRNAs (TS miRNA) specifically expressed in particular tissues play an important role in tissue identity, differentiation and function. However, transcription factor (TF) and TS miRNA regulatory networks across multiple tissues have not been systematically studied. Here, we manually extracted 116 TS miRNAs and systematically investigated the regulatory network of ...
Peng You Y Department of Oncological Surgery, Hangzhou First People's Hospital, Hangzhou 310006, China. - - 2014
This study screened microRNAs (miRNAs) that are abnormally expressed in papillary thyroid carcinoma (PTC) tissues to identify PTC and nodular goiter and the degree of PTC malignancy. A total of 51 thyroid tumor tissue specimens paired with adjacent normal thyroid tissues were obtained from the Department of Surgical Oncology of ...
Nokhbehsaim Marjan M Experimental Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany ; Clinical Research Unit 208, University of Bonn, 53111 Bonn, - - 2014
Obesity is increasing throughout the globe and characterized by excess adipose tissue, which represents a complex endocrine organ. Adipose tissue secrets bioactive molecules called adipokines, which act at endocrine, paracrine, and autocrine levels. Obesity has recently been shown to be associated with periodontitis, a disease characterized by the irreversible destruction ...
Passetti Fabio F Bioinformatics Unit, Clinical Research Coordination, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil, - - 2014
High-throughput sequencing (HTS) has emerged as a promising method to study gene expression in neoplastic and normal tissues. Using HTS, many research groups have described transcript variants as well as discovering new transcribed loci and noncoding RNAs, including microRNAs. In oncology, expression profiling of microRNAs in matched tumor and normal ...
Wang F F Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, - - 2014
Tumor-associated calcium signal transducer 2 (TACSTD2), a calcium signal transducer, is universally expressed in stratified squamous epithelia of many organs, including skin, esophagus and cervix. Although TACSTD2, was reported to be overexpressed in many epithelial tumors, which has increased interest in using it as a molecular target for cancer therapy, ...
Liu Na N Department of Stomatology, Chinese PLA General Hospital, Beijing, - - 2014
The formation and attachment of new cementum is crucial for periodontium regeneration. Tissue engineering is currently explored to achieve complete, reliable and reproducible regeneration of the periodontium. The capacity of multipotency and self-renewal makes adipose tissue-deprived stem cells (ADSCs) an excellent cell source for tissue regeneration and repair. After rat ...
Lai N N Yuchang Lin, Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University, Wuxi 214002, Jiangsu Province, China, e-mail: - - 2014
Introduction: The microRNA, miR-210, is frequently associated with hypoxia induction, and an increase in its levels is often correlated with poor prognosis in many solid tumours. The present study examines the levels of miR-210 in glioma tumours of multiple origins to determine if an association can be established with disease ...
Miller Antony J AJ The Department of Molecular Genetics, The Ohio State University, OH, - - 2014
Delta-like homologue 1 (Dlk1), an atypical Notch ligand, is known to have roles in growth and development, stem cell maintenance, and cancer. Evidence suggests that Dlk1 expression patterns are more complex than previously appreciated, with multiple isoforms expressed in various tissues in both the embryo and adult. However, the early ...
Zhang J - - 2014
Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) is an ubiquitously expressed cochaperone of heat shock cognate protein of 70 kDa (Hsc70). SGT binds to the C terminus of Hsc70 to recruit Hsc70 into complexes of diverse function. SGTB was identified as an isoform of SGT with 60% amino acid sequence homology. To ...
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