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Vincelli Gabriele G Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Irnerio 48, 40126, Bologna, (BO), - - 2015
The regulation of MOR expression at the level of mRNA is relevant for its role in pain transmission and in other functions involving opioid receptors. Recently, the role of the 3'UTR in the posttranscriptional regulation of MOR expression has been highlighted. Here we describe a Renilla luciferase reporter assay for ...
Arantes Ricardo Vinicius Nunes RV University of São Paulo, Bauru School of Dentistry, Department of Biological Sciences, Bauru, São Paulo, - - 2014
Background: Vascular endothelial growth factor (VEGF) plays an important role during angiogenesis and bone repair. This study investigated whether the use of meloxicam alters bone repair via down-regulation of VEGF and its receptors expression. Methods: 120 male Wistar rats had their upper right incisor extracted. Animals were divided into control ...
Zhou Zhen-Xing ZX Institute of Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, 310058, - - 2014
Quorum sensing molecular γ-butyrolactones (GBL) are widely distributed among the genus Streptomyces. Their cognate receptors have been demonstrated to control secondary metabolism and/or morphological differentiation. ScgA is responsible for the biosynthesis of GBL in Streptomyces chattanoogensis. According to the genome-wide transcriptome analysis of the ΔscgA mutant, we found that the ...
Jacob Aude A Inserm, UMR-S 1144, Paris, F-75006, France; Université Paris Descartes, UMR-S 1144, Paris, F-75006, France; Université Paris Diderot, UMR-S 1144, Paris, F-75013, - - 2014
The expression of aryl hydrocarbon receptor (AhR) transcription factor was detected at transcript level in freshly isolated human brain microvessels and in the hCMEC/D3 human cerebral microvascular endothelial cell line. Recent studies have demonstrated that AhR pathway is able to crosstalk with other pathways such as hypoxia signaling pathway. Therefore, ...
Lee D D Department of Biology, University of Toronto Mississauga, Mississauga, ON, - - 2014
Myosuppressins are a family of the FMRFamide-like peptides. They have been characterized in many insects and shown to inhibit visceral muscle contraction. Rhodnius prolixus possesses an unusual myosuppressin in that the typical FLRFamide C-terminal motif is unique and ends with FMRFamide. In the present study, we isolated the cDNA sequence ...
Kempisty Bartosz B Department of Histology and Embryology,Department of Anatomy,PoznanUniversity of Medical Sciences,6 Swiecickiego St.,60-781 - - 2014
Summary Although the expression of estrogen and progesterone receptors within porcine ovary and cumulus-oocyte complexes (COCs) is well recognized, still little information is known regarding expression of the progesterone receptor (PGR), PGR membrane component 1 (PGRMC1) and of estrogen-related receptors (ERRγ and ERRβ/γ) in separated cumulus cells in relation to ...
Seth-Vollenweider Tanya T Rutgers- New Jersey Medical School, United - - 2014
The SWI/SNF chromatin remodeling complex facilitates gene transcription by remodeling chromatin using the energy of ATP hydrolysis. Recent studies have indicated an interplay between the SWI/SNF complex and protein arginine methyltransferases (PRMTs). Little is known however about the role of SWI/SNF and PRMTs in vitamin D receptor (VDR) mediated transcription. ...
Peng Bo B Department of Obstetrics & Gynecology, Child & Family Research Institute, University of British Columbia, Vancouver, BC, - - 2014
Gonadotropin Releasing Hormone (GnRH) and its receptor GnRHR were shown to promote trophoblastic cell invasion. Detection of elevated early development related transcription factor TWIST and adhesion molecule N-cadherin in the invasive trophoblastic cells could possible suggest that GnRH promotes trophoblastic cell invasion through TWIST regulated N-cadherin pathway. To investigate the ...
Tabandeh Mohammad Reza MR Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz , Ahvaz , Iran - - 2014
Abstract Context: Rb1 ginsenoside, the key element of ginseng root, is widely used as an herbal therapeutic drug in diabetic patients. Various hypoglycemic mechanisms have been described for Rb1; however, to date, there has been no report on the effect of Rb1 on adiponectin signaling. Objectives: The current study was ...
Hong Hua H Department of Molecular Medicine, College of Medicine, Keimyung University, Dalseo-gu, Daegu 704-701, Republic of - - 2014
Hearing loss can be induced by multiple causes, including cochlear inflammation. Prednisone (PDN) is a well‑known steroid clinically used in the treatment of hearing loss. In the present study, we investigated the inhibitory effects and the mechanisms of action of PDN on the expression of cyclooxygenase (COX)-2, an inflammatory enzyme ...
Kühn Lukas C LC Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC - Swiss Institute for Experimental Cancer Research, EPFL_SV_ISREC, Room SV2516, Station 19, CH-1015 Lausanne, Switzerland. - - 2014
Cellular iron homeostasis is regulated by post-transcriptional feedback mechanisms, which control the expression of proteins involved in iron uptake, release and storage. Two cytoplasmic proteins with mRNA-binding properties, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a central role in this regulation. Foremost, IRPs regulate ferritin H and ...
Schmitt M M Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Campus North, Postfach 3640, Karlsruhe 76021, - - 2014
Wnt reception at the membrane is complex and not fully understood. CD44 is a major Wnt target gene in the intestine and is essential for Wnt-induced tumor progression in colorectal cancer. Here we show that CD44 acts as a positive regulator of the Wnt receptor complex. Downregulation of CD44 expression ...
Wang Qian Q Department of Clinical Laboratory Science, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, People's Republic of - - 2014
We previously reported that glucocorticoid receptor β (GRβ) regulates injury-mediated astrocyte activation and contributes to glioma pathogenesis via modulation of β-catenin/T-cell factor/lymphoid enhancer factor (TCF/LEF) transcriptional activity. The aim of this study was to characterize the mechanism behind cross-talk between GRβ and β-catenin/TCF in the progression of glioma. Here, we ...
Solaimani Parrisa P UCLA, United - - 2014
CYP1A1 bioactivates several procarcinogens and detoxifies several xenobiotic compounds. Transcription of CYP1A1 is highly induced by 2,3,7,8-tetrachlorodibenzo-р-dioxin (TCDD) via the aryl hydrocarbon receptor (AHR). We recently described an RNAi high throughput screening performed in the Hepa-1 mouse hepatoma cell line, which revealed that SIN3A is necessary for the induction of ...
Martin Elizabeth C - - 2014
The AKT/mammalian target of rapamycin (mTOR) signaling pathway is regulated by 17alpha-estradiol (E2) signaling and mediates E2-induced proliferation and progesterone receptor (PgR) expression in breast cancer.Methods and results: Here we use deep sequencing analysis of previously published data from The Cancer Genome Atlas to demonstrate that expression of a key ...
Dennis Stuart R SR Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield, UK, - - 2014
Elucidating the developmental and genetic control of phenotypic plasticity remains a central agenda in evolutionary ecology. Here, we investigate the physiological regulation of phenotypic plasticity induced by another organism, specifically predator-induced phenotypic plasticity in the model ecological and evolutionary organism Daphnia pulex. Our research centres on using molecular tools to ...
Lado Joanna J Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Valencia, Spain Instituto Nacional de Investigación Agropecuaria (INIA), - - 2014
Grapefruits are among the citrus species more sensitive to cold and develop chilling injury symptoms during prolonged postharvest storage at temperatures lower than 8 ℃-10 ℃. The plant hormone ethylene has been described either to protect or potentiate chilling injury development in citrus whereas little is known about transcriptional regulation of ethylene ...
Martineau Corine C Laboratoire du Métabolisme Osseux, BioMed, Département des Sciences Biologiques, Université du Québec à Montréal, Montréal, H3C 3P8, Quebec, - - 2014
Scavenger receptor class B type I (SR-BI), the Scarb1 gene product, is a high-density lipoprotein (HDL) receptor which was shown to influence bone metabolism. Its absence in mice is associated with alterations of the glucocorticoid/adrenocorticotropic hormone axis, and translated in high bone mass and enhanced bone formation. Since the cellular ...
Qin Qing Q Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA; Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai 200032, - - 2014
Endothelin-1 (ET-1) produced by vascular endothelial cells plays essential roles in the regulation of vascular tone and development of cardiovascular diseases. The objective of this study is to identify novel regulators implicated in the regulation of ET-1 expression in vascular endothelial cells (ECs). By using quantitative real-time PCR (qRT-PCR) and ...
Francis W R WR Institute of Life Science, College of Medicine, Swansea University, UK. Electronic address: - - 2014
During bone maintenance in vivo, estrogen signals through Estrogen receptor (ER)-α. The objectives of this study were to investigate the temporal expression of ERα36 and ascertain its functional relevance during osteogenesis in human bone marrow derived mesenchymal stromal cells (BMSC). This was assessed in relation to runt-related transcription factor-2 (runx2), ...
Zhao Jiangang J Institute of Molecular Medicine, The University of Texas Health Science Center Medical School at Houston, Houston, TX 77030, - - 2014
Pluripotent embryonic stem cells (ESCs) generate rostral paraxial mesoderm-like progeny in 5-6 days of differentiation induced by Wnt3a and Noggin (Nog). We report that canonical Wnt signaling introduced either by forced expression of activated β-catenin, or the small-molecule inhibitor of Gsk3, CHIR99021, satisfied the need for Wnt3a signaling, and that the ...
Park Phil June PJ Bioscience Research Division, R&D Unit, AmorePacific Corporation, Yongin-si, Gyeonggi-do, Republic of - - 2014
Substance P (SP) is a well-known neuropeptide implicated in the wound healing process. The wound occasionally causes a pigmented scar. In the present study, we examined whether increased levels of SP affected melanogenesis. When human melanocytes were treated with SP, the melanin content increased and the pigmentation process accelerated in ...
Gupta M M Physiology & Climatology Division, Indian Veterinary Research Institute, Izatnagar 243122, - - 2014
Ghrelin, a hormone predominantly found in the stomach, was recently described as a factor that controls female reproductive function. The aim of our study was to investigate the expression and localization of ghrelin and its active receptor, growth hormone secretagogue receptor type 1a (GHS-R1a) in buffalo ovarian follicles of different ...
He Fang F The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, - - 2014
Peroxisome proliferator-activated receptor δ (PPARδ) is a versatile regulator of distinct biological processes and overexpression of PPARδ in cancer may be partially related to its suppression of its own co-regulators. To determine whether recruited suppressor proteins bind to and regulate PPARδ expression, activity and PPARδ-dependent cholangiocarcinoma proliferation. Yeast two-hybrid assays ...
Manokawinchoke Jeeranan J Mineralized Tissue Research Unit, Faculty of Dentistry, Chulalongkorn University, Bangkok, - - 2014
Estrogen deficiency is associated with increased inflammation related periapical bone resorption. The present study aimed to evaluate the effect and intracellular mechanism(s) of estrogen on osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL) expression in human dental pulp cells (HDPs). HDPs were treated with estradiol at a ...
Mason Clifford C University of Kansas Medical Center; - - 2014
Prostaglandin E2 (PGE2), a major product of cyclooxygenase -2 (COX-2), acts as an immunomodulator at the maternal-fetal interface during pregnancy. It exerts biological function through interaction with E-prostanoid (EP) receptors localized to the placenta. The activation of the COX-2/PGE2/EP signal pathway can alter the expression of the ATP binding cassette ...
Kassem Kamal M KM Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, United - - 2014
Prostaglandin E2 (PGE2) is elevated during cardiac injury and we have previously shown that mice lacking the PGE2 EP4 receptor display dilated cardiomyopathy (DCM) with increased expression of the membrane type matrix metalloproteinase, MMP-14. We thus hypothesized that PGE2 regulates expression of MMP-14 and also affects fibroblast migration. Primary cultures ...
Cordes M A MA University of Wisconsin, Madison Department of Zoology: 430 Lincoln Ave. Madison, WI, USA. Electronic address: - - 2014
Across vertebrates, communication conveys information about an individual's motivational state, yet little is known about the neuroendocrine regulation of motivational aspects of communication. For seasonally breeding songbirds, increases in testosterone in spring stimulate high rates of sexually-motivated courtship song, though not all birds sing at high rates. It is generally ...
Pessemesse Laurence L INRA, UMR866 Dynamique Musculaire et Métabolisme, 2 place Viala, F-34060 Montpellier, France; Université Montpellier I et II, F-34060 Montpellier, - - 2014
We have previously identified in mitochondria two truncated forms of the T3 nuclear receptor TRα1, with molecular weights of 43kDa (p43) and 28kDa (p28) respectively located in the matrix and in the inner membrane. Previously, we have demonstrated that p43 stimulates mitochondrial transcription and protein synthesis in the presence of ...
Little Tanya Jane TJ University of Adelaide - - 2014
Fatty acids (FAs) stimulate the secretion of gastrointestinal hormones, including cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1), which suppress energy intake. In obesity, gastrointestinal responses to FAs are attenuated. Recent studies have identified a key role for the FA-sensing receptors, CD36, GPR40, GPR120, and GPR119, in mediating gastrointestinal hormone secretion. ...
Azimi Mohammad M Molecular Cell Biomechanics Laboratory, Departments of Bioengineering, Mechanical Engineering and Graduate Program in Chemical Biology, 208A Stanley Hall #1762, Berkeley, CA 94720, - - 2014
mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood. The density of export receptors that must bind an mRNA to ensure export, as well as how receptor distribution affects transport dynamics, ...
Marnetto Fabiana F Clinical Neurobiology Unit, Regional Referring Multiple Sclerosis Centre (CRESM), Neuroscience Institute Cavalieri Ottolenghi (NICO), University Hospital San Luigi Gonzaga, Orbassano, Turin, Italy; Clinical Neurology Unit, Regional Referring Multiple Sclerosis Centre (CReSM), University Hospital San Luigi Gonzaga,Orbassano, Turin, Italy. Electronic address: - - 2014
We compared pre-amplification (PA) RT-PCR blood CD19 mRNA quantification with flow cytometry (FC), to personalize rituximab re-treatment in neuromyelitis optica spectrum disorders (NMOSDs) patients. 47 blood samples from 3 NMOSDs patients were studied. PA-RT-PCR quantified CD19 in all samples, and a positivity threshold was defined, whereas CD19+ B cells were ...
Terashima Alexandra V AV Department of Genetics, Harvard Medical School, Boston, MA, - - 2014
Background Early embryo patterning is orchestrated by tightly regulated morphogen gradients. The Nodal morphogen patterns the mesendoderm, giving rise to all endoderm and head and trunk mesoderm. High Nodal concentrations favor endoderm differentiation while lower promote mesoderm differentiation. Nodal signaling is controlled by both positive and negative feedback regulation to ...
Guzmán A A 1Universidad Autónoma Metropolitana-Xochimilco,Calzada del Hueso 1100,CP 04960,México - - 2014
Blood vessel expansion and reduction in the corpus luteum (CL) is regulated by the vascular endothelial growth factor (VEGF) system and linked to the maintenance of the CL. The VEGF system has both angiogenic and antiangiogenic ligands and receptors. Our objective was to evaluate the relationship between the mRNA expression ...
Gerbal-Chaloin Sabine S http://orcid.org/0000-0002-2549-7899 INSERM U1040; - - 2014
The WNT/β-catenin/Adenomatous polyposis coli (CTNNB1/APC) pathway has been identified as a regulator of drug-metabolizing enzymes in rodent liver. Conversely, little is known about the role of this pathway in drug metabolism regulation in human liver. Primary human hepatocytes (PHHs) that are the most physiologically relevant culture system to study drug ...
Cizkova Katerina K Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech - - 2014
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-dependent transcription factor which is activated by various endogenous as well as exogenous compounds. It is involved in the regulation of a variety of biological processes, such as nutrient metabolism, energy homeostasis, immunological response and xenobiotic metabolism. Little is known about its expression ...
Yeon Jeong-Tae JT Research Institute of Basic Science, Sunchon National University, Suncheon, 540-742, Republic of - - 2014
Natural polyamines have numerous biological activities. Several studies have reported their beneficial role in bone metabolism, but their mode of action is not fully understood. Bone diseases such as osteoporosis, which is characterized by impaired bone structure and low bone mass, are caused by an increased number of osteoclasts and/or ...
Menon Bindu B Departments of Obstetrics/Gynecology and Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI - - - 2014
Downregulation of LH receptor (LHR) in the ovary by its ligand is mediated by a specific RNA binding protein designated as LHR mRNA binding protein (LRBP), through translational suppression and mRNA degradation. Using yeast two hybrid screens, we previously identified eukaryotic initiation factor 5A (eIF5A) as one of the proteins ...
Bishop Kathleen A KA Department of Biochemistry, University of Wisconsin-Madison, Madison, WI - - 2014
In addition to osteoblast lineage cells, the TNF-like factor Receptor Activator of NF-ΚB ligand (RANKL) is expressed in both B and T cells and may play a role in bone resorption. Rankl expression in mouse T cells is mediated through multiple distal elements marked by increased transcription factor occupancy, histone ...
Aoyagi Ryohei R Graduate School of Pharmaceutical Sciences, Keio - - 2014
Recent epidemiological studies showed that coffee consumption is associated with a lower risk of type 2 diabetes, presumably due to suppression of excess fat accumulation in adipocytes. However, the mechanism underlying the effect of coffee on adipocyte differentiation has not been well documented. To elucidate the mechanism, we investigated the ...
Al-Bader Maie Dawoud MD Department of Physiology, Faculty of Medicine, Kuwait University, Kuwait - - 2014
Metastasis-associated protein 1 (MTA1) and its short form (MTA1s) regulate the function of estrogen receptors (ERs). Estrogens, via ERs, affect placental growth and fetal development, a process that may involve MTA1 signaling. Expression of MTA1, MTA1s, ERα, and ERβ genes and proteins in rat placentas was studied on 16, 19, ...
Liu Xiyuan X Graduate School of Life Systems Sciences, Sookmyung Women's University, Seoul, Republic of - - 2014
Estrogen receptor α (ERα) plays a crucial role in estrogen-mediated signaling pathways and exerts its action as a nuclear transcription factor. Binding of the ligand-activated ERα to the estrogen response element (ERE) is a central part of ERα-associated signal transduction pathways and its aberrant modulation is associated with many disease ...
Drynda Andreas A Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, - - 2014
CXCR4, the chemokine receptor for CXCL12, also known as SDF-1 (stromal cell derived factor-1), has been shown to play a pivotal role in bone metastasis, inflammatory and autoimmune conditions but has not been investigated in periprosthetic osteolysis. We co-cultured osteoblast-like cells with increasing concentrations of metallic (Co-35Ni-20Cr-10Mo and Co-28Cr-6Mo) and ...
Evren Sevan S Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S - - 2014
Xenopus provides a well-studied model of vertebrate gastrulation, but a central feature, the movement of the mesoderm to the interior of the embryo, has received little attention. Here, we analyze mesoderm involution at the Xenopus dorsal blastopore lip. We show that a phase of rapid involution - peak involution - ...
Louw-du Toit Renate R University of Stellenbosch, South - - 2014
Medroxyprogesterone acetate (MPA), designed to mimic the actions of the endogenous hormone progesterone (Prog), is extensively used by women as a contraceptive and in hormone replacement therapy (HRT). However, little is known about the steroid receptor-mediated molecular mechanisms of action of MPA in the female genital tract. In this study, ...
Mekky Radwa Yehia RY The Molecular Pathology Research Group, German University in Cairo, Cairo, - - 2014
The tetraspanin CD81 is one of the main receptors involved in hepatitis C virus entry. Herein, we aimed to explore the role of microRNAs in regulating CD81 receptor expression and function. Bioinformatics analysis was carried out to select potential mircroRNAs that binds CD81 3'untranslated region. Liver biopsies taken from 28 ...
Yeh Meng Ching MC Division of General Surgery, Department of Surgery, Mackay Memorial Hospital Hsinchu Branch, Hsinchu, Taiwan - - 2014
Increase of μ-opioid receptor (MOR) expression in liver of diabetic rats has been mentioned to associate with hyperglycemia that can activate the signal transducer and activator of transcription 3 (STAT3) pathway. Additionally, STAT3 may regulate the expression of MOR genes. In the present study, role of STAT3 in the regulation ...
Mondal Bama Charan BC Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United - - 2014
Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells. We term the signal from differentiating cells the 'equilibrium signal' in order to distinguish it from the 'niche signal'. Earlier ...
Sung Ji Yeon JY Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, - - 2014
The protein C receptor (PROCR), toll-like receptor (TLR) and L-selectin leukocyte receptor play roles in systemic inflammatory response including disseminated intravascular coagulation (DIC). Expression of these receptors, which mediate systemic immune or coagulation responses, is tightly regulated by physiologic or pathologic signals. We investigated whether the expressions of 3 leukocyte ...
Mukherjee Arun A Pineal Research Lab., Department of Zoology, Banaras Hindu University, Varanasi 221005, India. Electronic address: - - 2014
Photoperiodic modulation of melatonin membrane receptor (MT1R) expression in testis has never been reported for any seasonal breeder. Thus, the aim of the present study was to investigate the expression dynamics of MT1R in testis and its interaction with testicular steroidogenesis in a long-day breeder, Mesocricetus auratus. Hamsters were exposed ...
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