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Manokawinchoke Jeeranan J Mineralized Tissue Research Unit, Faculty of Dentistry, Chulalongkorn University, Bangkok, - - 2014
Estrogen deficiency is associated with increased inflammation related periapical bone resorption. The present study aimed to evaluate the effect and intracellular mechanism(s) of estrogen on osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL) expression in human dental pulp cells (HDPs). HDPs were treated with estradiol at a ...
Mason Clifford C University of Kansas Medical Center; - - 2014
Prostaglandin E2 (PGE2), a major product of cyclooxygenase -2 (COX-2), acts as an immunomodulator at the maternal-fetal interface during pregnancy. It exerts biological function through interaction with E-prostanoid (EP) receptors localized to the placenta. The activation of the COX-2/PGE2/EP signal pathway can alter the expression of the ATP binding cassette ...
Little Tanya Jane TJ University of Adelaide - - 2014
Fatty acids (FAs) stimulate the secretion of gastrointestinal hormones, including cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1), which suppress energy intake. In obesity, gastrointestinal responses to FAs are attenuated. Recent studies have identified a key role for the FA-sensing receptors, CD36, GPR40, GPR120, and GPR119, in mediating gastrointestinal hormone secretion. ...
Azimi Mohammad M Molecular Cell Biomechanics Laboratory, Departments of Bioengineering, Mechanical Engineering and Graduate Program in Chemical Biology, 208A Stanley Hall #1762, Berkeley, CA 94720, - - 2014
mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood. The density of export receptors that must bind an mRNA to ensure export, as well as how receptor distribution affects transport dynamics, ...
Terashima Alexandra V AV Department of Genetics, Harvard Medical School, Boston, MA, - - 2014
Background Early embryo patterning is orchestrated by tightly regulated morphogen gradients. The Nodal morphogen patterns the mesendoderm, giving rise to all endoderm and head and trunk mesoderm. High Nodal concentrations favor endoderm differentiation while lower promote mesoderm differentiation. Nodal signaling is controlled by both positive and negative feedback regulation to ...
Guzmán A A 1Universidad Autónoma Metropolitana-Xochimilco,Calzada del Hueso 1100,CP 04960,México - - 2014
Blood vessel expansion and reduction in the corpus luteum (CL) is regulated by the vascular endothelial growth factor (VEGF) system and linked to the maintenance of the CL. The VEGF system has both angiogenic and antiangiogenic ligands and receptors. Our objective was to evaluate the relationship between the mRNA expression ...
Gerbal-Chaloin Sabine S http://orcid.org/0000-0002-2549-7899 INSERM U1040; - - 2014
The WNT/β-catenin/Adenomatous polyposis coli (CTNNB1/APC) pathway has been identified as a regulator of drug-metabolizing enzymes in rodent liver. Conversely, little is known about the role of this pathway in drug metabolism regulation in human liver. Primary human hepatocytes (PHHs) that are the most physiologically relevant culture system to study drug ...
Cizkova Katerina K Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech - - 2014
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-dependent transcription factor which is activated by various endogenous as well as exogenous compounds. It is involved in the regulation of a variety of biological processes, such as nutrient metabolism, energy homeostasis, immunological response and xenobiotic metabolism. Little is known about its expression ...
Yeon Jeong-Tae JT Research Institute of Basic Science, Sunchon National University, Suncheon, 540-742, Republic of - - 2014
Natural polyamines have numerous biological activities. Several studies have reported their beneficial role in bone metabolism, but their mode of action is not fully understood. Bone diseases such as osteoporosis, which is characterized by impaired bone structure and low bone mass, are caused by an increased number of osteoclasts and/or ...
Menon Bindu B Departments of Obstetrics/Gynecology and Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI - - - 2014
Downregulation of LH receptor (LHR) in the ovary by its ligand is mediated by a specific RNA binding protein designated as LHR mRNA binding protein (LRBP), through translational suppression and mRNA degradation. Using yeast two hybrid screens, we previously identified eukaryotic initiation factor 5A (eIF5A) as one of the proteins ...
Bishop Kathleen A KA Department of Biochemistry, University of Wisconsin-Madison, Madison, WI - - 2014
In addition to osteoblast lineage cells, the TNF-like factor Receptor Activator of NF-ΚB ligand (RANKL) is expressed in both B and T cells and may play a role in bone resorption. Rankl expression in mouse T cells is mediated through multiple distal elements marked by increased transcription factor occupancy, histone ...
Aoyagi Ryohei R Graduate School of Pharmaceutical Sciences, Keio - - 2014
Recent epidemiological studies showed that coffee consumption is associated with a lower risk of type 2 diabetes, presumably due to suppression of excess fat accumulation in adipocytes. However, the mechanism underlying the effect of coffee on adipocyte differentiation has not been well documented. To elucidate the mechanism, we investigated the ...
Al-Bader Maie Dawoud MD Department of Physiology, Faculty of Medicine, Kuwait University, Kuwait - - 2014
Metastasis-associated protein 1 (MTA1) and its short form (MTA1s) regulate the function of estrogen receptors (ERs). Estrogens, via ERs, affect placental growth and fetal development, a process that may involve MTA1 signaling. Expression of MTA1, MTA1s, ERα, and ERβ genes and proteins in rat placentas was studied on 16, 19, ...
Liu Xiyuan X Graduate School of Life Systems Sciences, Sookmyung Women's University, Seoul, Republic of - - 2014
Estrogen receptor α (ERα) plays a crucial role in estrogen-mediated signaling pathways and exerts its action as a nuclear transcription factor. Binding of the ligand-activated ERα to the estrogen response element (ERE) is a central part of ERα-associated signal transduction pathways and its aberrant modulation is associated with many disease ...
Drynda Andreas A Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, - - 2014
CXCR4, the chemokine receptor for CXCL12, also known as SDF-1 (stromal cell derived factor-1), has been shown to play a pivotal role in bone metastasis, inflammatory and autoimmune conditions but has not been investigated in periprosthetic osteolysis. We co-cultured osteoblast-like cells with increasing concentrations of metallic (Co-35Ni-20Cr-10Mo and Co-28Cr-6Mo) and ...
Evren Sevan S Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S - - 2014
Xenopus provides a well-studied model of vertebrate gastrulation, but a central feature, the movement of the mesoderm to the interior of the embryo, has received little attention. Here, we analyze mesoderm involution at the Xenopus dorsal blastopore lip. We show that a phase of rapid involution - peak involution - ...
Louw-du Toit Renate R University of Stellenbosch, South - - 2014
Medroxyprogesterone acetate (MPA), designed to mimic the actions of the endogenous hormone progesterone (Prog), is extensively used by women as a contraceptive and in hormone replacement therapy (HRT). However, little is known about the steroid receptor-mediated molecular mechanisms of action of MPA in the female genital tract. In this study, ...
Mondal Bama Charan BC Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United - - 2014
Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells. We term the signal from differentiating cells the 'equilibrium signal' in order to distinguish it from the 'niche signal'. Earlier ...
Mekky Radwa Yehia RY The Molecular Pathology Research Group, German University in Cairo, Cairo, - - 2014
The tetraspanin CD81 is one of the main receptors involved in hepatitis C virus entry. Herein, we aimed to explore the role of microRNAs in regulating CD81 receptor expression and function. Bioinformatics analysis was carried out to select potential mircroRNAs that binds CD81 3'untranslated region. Liver biopsies taken from 28 ...
Yeh Meng Ching MC Division of General Surgery, Department of Surgery, Mackay Memorial Hospital Hsinchu Branch, Hsinchu, Taiwan - - 2014
Increase of μ-opioid receptor (MOR) expression in liver of diabetic rats has been mentioned to associate with hyperglycemia that can activate the signal transducer and activator of transcription 3 (STAT3) pathway. Additionally, STAT3 may regulate the expression of MOR genes. In the present study, role of STAT3 in the regulation ...
Sung Ji Yeon JY Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, - - 2014
The protein C receptor (PROCR), toll-like receptor (TLR) and L-selectin leukocyte receptor play roles in systemic inflammatory response including disseminated intravascular coagulation (DIC). Expression of these receptors, which mediate systemic immune or coagulation responses, is tightly regulated by physiologic or pathologic signals. We investigated whether the expressions of 3 leukocyte ...
Mukherjee Arun A Pineal Research Lab., Department of Zoology, Banaras Hindu University, Varanasi 221005, India. Electronic address: - - 2014
Photoperiodic modulation of melatonin membrane receptor (MT1R) expression in testis has never been reported for any seasonal breeder. Thus, the aim of the present study was to investigate the expression dynamics of MT1R in testis and its interaction with testicular steroidogenesis in a long-day breeder, Mesocricetus auratus. Hamsters were exposed ...
Costa M A MA Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal; Instituto de Biologia Celular e Molecular da Universidade do Porto (IBMC), Porto, - - 2014
A balanced cytotrophoblast cell turnover is crucial for placental development and anomalies in this process associated with gestational diseases. The Endocannabinoid System (ECS) has emerged as a new player in several biological processes. However, its influence during placental development is still unknown. We report here the expression of the endocannabinoid ...
Schmidt Yvonne - - 2014
Abstract Adequate vascularization is an essential requirement for bone development, fracture healing and bone tissue engineering. We have previously described the coculture of primary human osteoblasts (hOBs) and human endothelial cells (HUVECs), designed to investigate the interactions between these cells. In this system, we showed that cocultivation of these two ...
Domingue Jada C JC Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, - - 2014
The Human Embryonic Kidney 293 cell line (HEK-293) readily lends itself to genetic manipulation and is a common tool for biologists to overexpress proteins of interest and study their function and molecular regulation. Although these cells have some limitations, such as an inability to form resistive monolayers necessary for studying ...
Schmidt Carolin C Division of Neonatology, Center for Pediatric Research Leipzig, Hospital for Children & Adolescents, University of Leipzig, 04103, Leipzig, - - 2014
Glucocorticoids and progesterone exert stimulatory effects on epithelial Na(+) transport, including increased mRNA expression of the participating ion transporters (epithelial Na(+) channels [ENaC] and Na,K-ATPases) and their electrophysiological activity. Fetuses threatened by preterm labor may receive high doses of glucocorticoids to stimulate lung maturation and are naturally exposed to high ...
Mooney Steven M SM The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicinexs, Baltimore, MD, 21287; The James Buchanan Brady Urological Institute and Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287; The James Buchanan Brady Urological Institute and Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, - - 2014
Zinc finger E-box binding homeobox 1 (ZEB1) is a transcription factor that plays a central role in the epithelial to mesenchymal transition (EMT) of cancer cell lines. Studies on its regulation have mostly focused on the negative 3'UTR binding of miR200c. Interestingly, it has been previously reported that androgen receptor ...
Bellaïche Johanna - - 2014
What makes the spermatogonial stem cells (SSCs) self-renew or differentiate to produce spermatozoa is barely understood, in particular in non-mammalian species. Our research explores possible regulations of the spermatogonial stem cell niche in teleost, locally by paracrine factors and peripherally by hormonal regulation. In the present study, we focus on ...
Wu Jiaguo J Division of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310058, PR - - 2014
NF-E2 P45-related factor 2 (Nrf2) is a key transcription factor that controls genes encoding cytoprotective and detoxifying enzymes through antioxidant response elements (AREs) in their regulatory regions. We reported recently that retinoid X receptor alpha (RXRα) inhibits NRF2 function by direct interaction with the Neh7 domain of NRF2 in a ...
Li X X Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China, - - 2014
To investigate the effects of Exendin-4 (Ex-4), a glucagon-like peptide-1 (GLP-1) receptor agonist, on the expression of C1q/TNF-related protein-3 (CTRP3), a novel adipokine, in 3T3-L1 adipocytes. The role of protein kinase A (PKA) signal pathway in the effects was also investigated. The mRNA and protein expressions of CTRP3 in 3T3-L1 ...
Kavarthapu Raghuveer R Section on Molecular Endocrinology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, - - 2014
Prolactin (PRL) serves a critical role in breast cancer progression via activation of its cognate receptor. These studies reveal up-regulation of PRLR gene expression by PRL in absence of estradiol in MCF-7 and T47D breast cancer cells. PRL/PRLR via activation of STAT5 that binds a GAS-element in the PRLR gene ...
Besancenot Rodolphe R Inserm UMR1009, Villejuif, - - 2014
Megakaryopoiesis is a two-step differentiation process regulated by thrombopoietin (TPO), upon binding to its cognate receptor MPL. This receptor associates with intracytoplasmic tyrosine kinases, essentially JAK2 that regulates MPL stability and cell surface expression, and mediates TPO-induced signal transduction. We demonstrate that JAK2 and MPL mediate TPO-induced proliferation arrest and ...
Toms Derek D Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada N1G - - 2014
In developing ovarian follicles, the progesterone receptor (PGR) is essential for mediating transcription of key factors that coordinate cellular functions including follicular remodeling. With recent investigations examining the role of microRNA (miRNA) in regulating ovarian function we used a lentiviral approach to over express miR-378 in cultured primary porcine granulosa ...
Kowalik Magdalena K MK Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland. Electronic address: - - 2014
The aim of this study was to evaluate the mRNA and protein expression and the localization of progesterone receptor membrane component 1 (PGRMC1), PGRMC2, and the PGRMC1 partner serpine mRNA binding protein 1 (SERBP1) in the bovine CL on Days 2 to 5, 6 to 10, 11 to 16, and ...
Cho Jung-Sun JS Brain Korea 21 Plus for Biomedical Science, Korea University College of Medicine, Seoul, Korea. ; Institute for Medical Devices Clinical Trial Center, Guro Hospital, Korea University, Seoul, - - 2014
Interleukin 6 (IL-6) and IL-8 participate in the pathogenesis of chronic rhinosinusitis with nasal polyps, and their levels are increased by prostaglandin E2 (PGE2) in different cell types. The purposes of this study were to determine whether PGE2 has any effect on the increase in the levels of IL-6 and ...
Ranjan Amit A 0000-0002-7900-982X Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Sector 22, Kharghar, Navi Mumbai 410210, - - 2014
Matrix remodeling and invasion of basement membrane are the major determinants of malignant progression. Matrix degrading enzymes play a pivotal role in this process and have been shown to be regulated at multiple levels. Using high metastatic B16F10 and its invasive variant B16BL6 cells, we previously demonstrated that the expression ...
Bai Xinlei X Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou 510632, China Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Jinan University, Guangzhou 510632, China International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou 510632, China Department of Developmental & Regenerative Biology, Ji Nan University Guangzhou 510632, - - 2014
Recent studies revealed that BDNF-TrkB pathway plays an important role in cardiac microvascular endothelial cells (CMECs) mediated myocardial angiogenesis. Single-cell analysis is a powerful tool for studying gene expression in individuals since cellular heterogeneity and dynamic microenvironments which individual cell will experience. Little is currently known about the expression of ...
Lan Xun - - 2012
Transcriptional regulation is a critical mediator of many normal cellular processes, as well as disease progression. Transcription factors (TFs) often co-localize at cis-regulatory elements on the DNA, form protein complexes, and collaboratively regulate gene expression. Machine learning and Bayesian approaches have been used to identify TF modules in a one-dimensional ...
Gburcik Valentina - - 2012
The transcription factor Tbx15 is predominantly expressed in brown adipose tissue and in those white adipose depots that are capable of giving rise to brown-in-white ('brite'/'beige') adipocytes. We have therefore investigated here a possible role of Tbx15 in brown and brite adipocyte differentiation in vitro. Adipocyte precursors were isolated from ...
Barthold Julia Spencer - - 2012
To better define the developmental mechanisms of nonsyndromic cryptorchidism, we measured the expression of hormone receptor and muscle type specific mRNAs in target tissues of boys with and those without nonsyndromic cryptorchidism. Prospectively collected cremaster muscle and/or hernia sac tissues from boys with congenital (79) or acquired (66) nonsyndromic cryptorchidism ...
Pascual G - - 2012
PURPOSE: The use prosthetic materials for the surgical repair of abdominal wall defects has become almost standard practice. This study was designed to assess the expression of different growth factors (VEGF/TGF-β1) and macrophages during the early host tissue incorporation of several polypropylene lightweight (PP-LW)-including one partially absorbable-and heavyweight (PP-HW) prosthetic ...
Gosemann Jan-Hendrik - - 2012
Malformations of the pleuroperitoneal folds (PPFs) have been identified as the origin of the diaphragmatic defect in congenital diaphragmatic hernia (CDH). Pax3, expressed in muscle precursor cells (MPCs), plays a key role in regulating myogenesis and muscularization in the fetal diaphragm. Pax3 mutant mice display absence of muscular diaphragm. However, ...
Stelmanska Ewa - - 2012
Progesterone affects lipid metabolism in adipose tissue and influences fat distribution in human. The aim of the study was to analyze the effect of progesterone on rat body and fat mass and on expression of genes encoding adipokines involved in the regulation of energy homeostasis. The results presented here indicate ...
Nguyen Phuoc T - - 2012
ABSTRACT Synthetic mesh is widely used for hernia repairs, but mesh-induced chronic inflammatory responses may lead to postoperative complications. We previously showed an elevated response to multifilament polyester (PE) versus monofilament polypropylene (PP) and polytetrafluoroethylene (PTFE) meshes, but it is unclear whether this discrepancy is due to the differences in ...
Pascual Gemma - - 2012
Collagen prostheses used to repair abdominal wall defects, depending on their pretreatment (noncross-linked vs. cross-linked), besides repair may also achieve tissue regeneration. We assessed the host tissue incorporation of different bioprostheses using a new tool that combines immunofluorescence confocal microscopy with differential interference contrast images, making it possible to distinguish ...
Kershaw Rachael M - - 2012
Gene-environment interactions influence an individual's risk of disease development. A common human 8-oxoguanine DNA glycosylase 1 (OGG1) variant, Cys326-hOGG1, has been associated with increased cancer risk. Evidence suggests that this is due to reduced repair ability, particularly under oxidising conditions but the underlying mechanism is poorly understood. Oxidising conditions may ...
Rovin Molly L - - 2012
Activity of locus coeruleus (LC) neurons and release of the peptide galanin (GAL), which is colocalized with norepinephrine (NE) in LC neurons, has been implicated in depression and, conversely, in antidepressant action. The present study examined the influence of chronic administration (for 14days, via subcutaneously-implanted minipump) of antidepressant (AD) drugs ...
van den Driesche Sander S MRC Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom. - - 2012
Reproductive disorders that are common/increasing in prevalence in human males may arise because of deficient androgen production/action during a fetal 'masculinization programming window'. We identify a potentially important role for Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) in Leydig cell (LC) steroidogenesis that may partly explain this. In rats, fetal ...
Aloe Luigi - - 2011
Type 1 diabetes (DB) is a multifactorial metabolic disorder characterized by loss of insulin-producing pancreatic ß-cells, and metabolic and functional deficits in a number of cells, including kidney cells. Nerve growth factor (NGF) is a signaling molecule that is up-regulated in cells affected by diabetes-linked disorders. However, whether DB alters ...
Zemtsova Irina I Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich-Heine University, Düsseldorf, - - 2011
Astrocytes play an important role in the pathogenesis of hepatic encephalopathy (HE) and ammonia toxicity, whereas little is known about microglia and neuroinflammation under these conditions. We therefore studied the effects of ammonia on rat microglia in vitro and in vivo and analyzed markers of neuroinflammation in post mortem brain ...
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