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Kim Jeffrey J JJ Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, - - 2014
It has been reported that nicotine/alcohol alter epigenetic control and lead to abrogated DNA methylation and histone modifications, which could subsequently perturb transcriptional regulation critically important in cellular transformation. The aim of this study is to determine the molecular mechanisms of nicotine/alcohol-induced epigenetic alterations and their mechanistic roles in transcriptional ...
Kjærup R M RM Department of Animal Science, Aarhus University, Blichers Allé 20, P.O. Box 50, 8830, Tjele, - - 2014
The serum collectin mannose-binding lectin (MBL) plays a major role in innate immunity by activation of the lectin complement pathway or by acting as an opsonin. The serum levels of human and animal MBL are associated with susceptibility to a wide range of infections, and the variation of MBL in ...
Zhang Yujing Y College of Food Science and Nutritional Engineering, China Agricultural University, Qinghua East Road No. 17, Haidian District, Beijing, 100083, - - 2014
In plants, hexokinase (HXK, EC 2.7.1.1), an enzyme normally involved in hexose phosphorylation, plays an important role in sugar sensing and signaling. The hexokinase activity of grape HXKs was confirmed by functional complementation of the hexokinase-deficient yeast strain YSH7.4-3C (hxk1, hxk2, glk1). HXK1 and HXK2 were able to complement this ...
Fang Lanlan L Reproductive Medical Center (L.F., Y.-P.S.), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China 450052; and Department of Obstetrics and Gynaecology (H.-M.C., J.-C.C., P.C.K.L.), Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z - - 2014
Context: Regulation of progesterone production in granulosa cells is important for normal reproductive functions. Steroidogenic acute regulatory protein (StAR) is recognized as the key regulatory protein involved in the rate-limiting step of steroidogenesis. TGF-β1 protein is detected in human follicular fluid, and TGF-β1 and its receptors are expressed in human ...
Chen Wanghao W Department of Neurosurgery, People's Hospital Affiliated to Jiangsu University, Zhenjiang, - - 2014
MicroRNAs (miRNAs) have gained much attention due to their critical roles in diverse biological events, including tumorigenesis. In this study, we demonstrate that miR-136 is down-regulated in two cohorts of patients with glioma. Furthermore, the low-level expression of miR-136 is significantly associated with a more aggressive and/or poor prognostic phenotype ...
Li Hang Wun Raymond HW Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong Centre for Reproduction, Development and Growth, The University of Hong Kong, Hong Kong - - 2014
Do ulipristal acetate (UPA) and mifepristone have an effect on ciliary beat frequency and muscular contractions in the human Fallopian tube? UPA, in resemblance to mifepristone, inhibits ciliary beat and muscular contraction of the human Fallopian tube, probably through an agonistic effect on the tubal progesterone receptor. UPA, like mifepristone, ...
Utami Kagistia Hana KH Human Genetics, Genome Institute of Singapore, 138672, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, - - 2014
MED13L is a component subunit of the Mediator complex, an important regulator of transcription that is highly conserved across eukaryotes. Here we report MED13L disruption in a translocation t(12;19) breakpoint of a patient with Pierre-Robin syndrome, moderate intellectual disability (ID), craniofacial anomalies, and muscular defects. The phenotype is similar to ...
Hu Yixin - - 2014
Objectives This study focused on the expression pattern and clinical significance of B7-H3 expression in human acute leukemia. Methods We systematically analyzed 134 patients with acute myeloid leukemia (101 cases) and acute lymphocytic leukemia (33 cases) by flow cytometry. Results The frequency of B7-H3(+) cases was 44.8% in total. The ...
Zhang Zhichun Z Department of Cariology and Endodontology, School and Hospital of Stomatology, Peking University, Beijing, People's Republic of - - 2014
Wingless-type MMTV integration site family, member 10A (WNT10A) plays crucial roles in odontogenesis. The aim of this study was to investigate the effects of WNT10A on human dental pulp cells (DPCs), which contain a mixed population of cells, including stem and progenitor cells, and participate in dentin repair or dentin-pulp ...
Jin Yanli Y Department of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, - - 2014
Human basal-like breast cancer (BLBC) has a poor prognosis and is often identified by expression of the epidermal growth factor receptor (EGFR). BLBC remains a major clinical challenge because its pathogenesis is not well understood, thus hindering efforts to develop targeted therapies. Recent data implicate the forkhead box C1 (FOXC1) ...
Kanski R - - 2014
Glial Fibrillary Acidic Protein (GFAP) is the main intermediate filament in astrocytes and is regulated by epigenetic mechanisms during development. We demonstrate that histone acetylation controls GFAP expression also in mature astrocytes. Inhibition of histone deacetylases (HDACs) with Trichostatin-A or Sodium-butyrate reduced GFAP expression in primary human astrocytes and astrocytoma ...
Suzuki Koji K Department of Internal Medicine II, University of Yamanashi, Faculty of - - 2014
Aim: Eicosanoids play various pathogenic roles in aortic valve calcification. Eicosanoids are derived from the arachidonic acid generated by phospholipase A2 (PLA2). We therefore sought to determine whether PLA2s are expressed in human aortic valves and, if so, whether the expression of PLA2s is related to the expression of osteogenic ...
Shuai Shuai S Cancer Center, Traditional Chinese Medicine-Integrated Hospital, Southern Medical University, Guangzhou, Guangdong 510315, - - 2014
Aberrant epidermal growth factor (EGF)-dependent signaling plays a key role in the progression of human carcinomas. We found that TIP30, a tumor suppressor protein, translocated into the nucleus of human lung adenocarcinoma cells following EGF treatment, and the selective inhibitors of EGFR signaling pathways blocked this effect. Chromatin immunoprecipitation assays ...
Kotta-Loizou Ioly I Division of Cell and Molecular Biology, Imperial College London, London, - - 2014
Hu-antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and nucleus-to-cytoplasm translocation of target mRNAs. The aim of the present review was to summarize and present the currently available information in the English literature on HuR expression in various human tumors, verifying its possible clinical significance. HuR ...
Giannarelli Chiara C Icahn School of Medicine at Mount Sinai, New York, NY - - 2014
-Alternatively Spliced Tissue Factor (asTF) is a novel isoform of full-length Tissue Factor (fl-TF) that exhibits angiogenic activity. Although asTF has been detected in human plaques, it is unknown whether its expression in atherosclerosis causes increased neovascularization and an advanced plaque phenotype. -Carotid (n=10) and coronary specimens (n=8), from patients ...
Lutwak Ela E E Lutwak, Hematology, Western Galilee Hospital, Naharia, - - 2014
Sef is a tumor suppressor and an inhibitor of growth factors as well as of pro-inflammatory cytokine signaling. In the present study we examined the regulation of Sef expression by gonadotropins during ovarian folliculogenesis. In sexually immature mice, in situ hybridization (ISH) localized Sef gene expression to early developing oocytes ...
Quenet Delphine D Laboratory of Receptor Biology & Gene Expression, Center for Cancer Research, National Cancer Institute, Bethesda, United - - 2014
The centromere is a specialized chromatin region marked by the histone H3 variant CENP-A. Although active centromeric transcription has been documented for over a decade, the role of centromeric transcription or transcripts has been elusive. Here, we report that centromeric α-satellite transcription is dependent on RNA Polymerase II and occurs ...
Francis Heather H Research, Central Texas Veterans Health Care System, Temple, TX, USA, United - - 2014
IL-6/Stat3 is associated with the regulation of transcription of key cellular regulatory genes [microRNAs (miRNAs)] during different types of liver injury. This study evaluated the role of IL-6/Stat3 in regulating miRNA and miR-21 in alcoholic liver disease. By microarray, we identified that ethanol feeding significantly up-regulated 0.8% of known miRNAs ...
Iyer A M - - 2014
Metabotropic glutamate receptor 5 (mGluR5) is highly expressed throughout the forebrain and hippocampus. Several lines of evidence support the role of this receptor in brain development and developmental disorders, as well as in neurodegenerative disorders like Alzheimer's disease (AD). In the present study, the expression pattern of mGluR5 was investigated ...
Weng Hui H Department of Dermatology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong 519000, P.R. - - 2014
Accumulative evidence has demonstrated that inflammation has an important role in human papillomavirus (HPV) oncogenicity. However, the effects of high mobility group protein box 1 (HMGB1)-toll like receptor 4 (TLR4) signaling pathway associated inflammation on epidermal warts caused by HPV remain unclear. The present study investigated the HMGB1, TLR4 and nuclear ...
Schulkens Iris A IA Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, The - - 2014
Metallothioneins (MTs) are small cysteine-rich proteins which are involved in e.g. metal homeostasis, metal detoxification and protection against oxidative stress. In addition, several MTs have been shown to regulate expression of proangiogenic growth factors like vascular endothelial growth factor. Detailed information about the expression and regulation of specific MT isoforms ...
Gotoh Tetsuya T Integrated Cellular Responses Laboratory, Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, - - 2014
Period 2 (hPer2) is a transcriptional regulator placed at the core of the circadian clock mechanism that is responsible for generating the negative feedback loop that sustains the clock. Its relevance to human disease is underlined by alterations in its function that impacts numerous biochemical and physiological processes. When absent, ...
Ruiz Alba A IrsiCaixa, - - 2014
HIV-1 exploits multiple host proteins during infection. siRNA-based screenings have identified new proteins implicated in different pathways of the viral cycle that participate in a broad range of cellular functions. The Human Mediator Complex (MED) is composed by 28 elements and represents a fundamental component of the transcription machinery, interacting ...
Han Jiyeon J R&D Unit, AmorePacific Corporation, Yongin-si, Gyeonggi-do, - - 2014
Ginsenoside F1 (GF1) is a metabolite of ginsenoside Rg1. Although GF1 has several benefits for skin physiology, the effect of GF1 on skin pigmentation has not been reported. We found that a cream containing 0.1% GF1 showed a significant whitening effect on artificially tanned human skin after 8 weeks of ...
Ohnuki Mari M Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan; - - 2014
Pluripotency can be induced in somatic cells by overexpressing transcription factors, including POU class 5 homeobox 1 (OCT3/4), sex determining region Y-box 2 (SOX2), Krüppel-like factor 4 (KLF4), and myelocytomatosis oncogene (c-MYC). However, some induced pluripotent stem cells (iPSCs) exhibit defective differentiation and inappropriate maintenance of pluripotency features. Here we ...
Korf Katharina K Research Institute Children's Cancer Center Hamburg, 20251 Hamburg, - - 2014
In most acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion gene. Although expression of the human PML fusion in mice promotes leukemia, its efficiency is rather low. Unexpectedly, we find that simply replacing the human PML fusion with its mouse counterpart results ...
Oka Yasuyoshi Y Ubiquitin Signaling Group, Department of Disease Biology, The Novo Nordisk Foundation Center for Protein Research University of Copenhagen, Copenhagen, - - 2014
UBL5 is an atypical ubiquitin-like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre-mRNA splicing efficiency, leading to globally enhanced intron retention. Defective sister chromatid cohesion ...
Ota Takumi T Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, - - 2014
The 3β-hydroxysteroid dehydrogenase (3β-HSD) is an enzyme crucial for steroid synthesis. Two different 3β-HSD isoforms exist in human. Classically, HSD3B2 was considered the principal isoform present in the adrenal. However, we recently showed that the alternative isoform HSD3B1 is expressed specifically within the adrenal zona glomerulosa (ZG), where aldosterone is ...
Wang Dong D Department of Surgery, University of Colorado Denver, Aurora, CO 80045; Department of Anatomy, The Second Military Medical University, Shanghai, - - 2014
Calcific aortic valve disease (CAVD) is a chronic inflammatory condition and affects a large number of elderly people. Aortic valve interstitial cells (AVICs) occupy an important role in valvular calcification and CAVD progression. While pro-inflammatory mechanisms are capable of inducing the osteogenic responses in AVICs, the molecular interaction between pro-inflammatory ...
Zhang Fang-Jie FJ Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. - - 2014
Tissue inhibitors of metalloproteinases (TIMPs) regulate the activity of matrix metalloproteinases (MMPs) and enzymes from the a disintegrin and metalloproteinase domain with thrombospondin motifs family in osteoarthritis (OA). Elevated osteopontin (OPN) levels in plasma, synovial fluid and articular cartilage are associated with progressive OA joint damage; however, the role of ...
Rappa Francesca F Department of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, Palermo, Italy Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy - - 2014
Heat shock proteins (Hsps) assist other proteins in their folding and drive the degradation of defective proteins. During evolution, these proteins have also acquired other roles. Hsp10 is involved in immunomodulation and tumor progression. Hsp90 stabilizes a range of "client" proteins involved in cell signaling. The present study evaluated the ...
Honda Teruko T Department of Medical Technology, School of Life and Environmental Science, Azabu University, Sagamihara, Kanagawa, Japan - - 2014
We have previously reported that mRNA expression of chemotaxis- and angiogenesis-related factors in human monocytes increased following interaction with colon cancer cells. Recently, it was also reported that mRNA expression of the chemotaxis-related factor, monocyte chemotactic protein (MCP)-1, in mouse macrophages following treatment with low-dose lipopolysaccharide (LPS) was significantly lower ...
Traister Russell S RS Department of Medicine, University of Pittsburgh, Pittsburgh, Pa. Electronic address: - - 2014
Severe asthma remains poorly characterized, although it likely consists of at least 1 phenotype with features of TH2-like inflammation. IL1RL1, encoding both the IL-33 receptor, ST2L, and decoy receptor, sST2, has been genetically associated with asthma, though the mechanism for susceptibility remains unknown. Given previous data supporting a role for ...
Niu Yong-Zhi YZ Institute of Otorhinolaryngology, Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, - - 2014
Recent studies indicated that interleukin (IL)-17, growth-related oncogene (GRO)-α and IL-8 play an important role in the pathogenesis of nasal polyps. However, the effects of the increased amount of IL-17 and the production of GRO-α and IL-8 in human nasal polyp fibroblasts are not completely understood. This study aimed to ...
Trimarchi Thomas T Howard Hughes Medical Institute, Laura and Isaac Perlmutter Cancer Center, and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA; Department of Pathology, NYU School of Medicine, 550 First Avenue, New York, NY 10016, - - 2014
Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here we investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemia (T-ALL). By integrating ...
Ji Y Y Departments of Medicine and Medical Pharmacology & Physiology, University of Missouri School of Medicine, Columbia, MO, - - 2014
C-reactive protein (CRP) promotes tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) expression in vitro, and elevated plasma CRP concentration is associated with increased risk of vein graft (VG) thrombosis after coronary artery bypass surgery. However, little is known about the effects of CRP on VG TF and PAI-1 expression ...
Diao Liyang L BioMaPS Institute for Quantitative Biology and Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, - - 2014
microRNAs (miRNAs) are a class of ∼22nt non-coding RNAs that potentially regulate over 60% of human protein-coding genes. miRNA activity is highly specific, differing between cell types, developmental stages and environmental conditions, so the identification of active miRNAs in a given sample is of great interest. Here we present a ...
Martín-González J J Department of Stomatology (Endodontics section), School of Dentistry, University of Sevilla, Sevilla, - - 2014
To investigate the expression and immunohistochemical localization of LEPR in human periapical granulomas. Periapical inflammatory lesions were obtained from extracted human teeth and teeth which underwent periapical surgery. After their histopathological categorization as periapical granulomas (n = 20), they were examined by immunohistochemistry using human LEPR monoclonal antibodies. LEPR mRNA ...
Hällberg B Martin BM Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden; Röntgen-Ångström-Cluster, Karolinska Institutet Outstation, Centre for Structural Systems Biology, DESY Campus, 22603 Hamburg, Germany; European Molecular Biology Laboratory, Hamburg Unit, 22603 Hamburg, Germany. Electronic address: - - 2014
Understanding regulation of mitochondrial DNA (mtDNA) expression is of considerable interest given that mitochondrial dysfunction is important in human pathology and aging. Similar to the situation in bacteria, there is no compartmentalization between transcription and translation in mitochondria; hence, both processes are likely to have a direct molecular crosstalk. Accumulating ...
Hause Ronald J RJ Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA; Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA; Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, - - 2014
Many genetic variants associated with human disease have been found to be associated with alterations in mRNA expression. Although it is commonly assumed that mRNA expression changes will lead to consequent changes in protein levels, methodological challenges have limited our ability to test the degree to which this assumption holds ...
Tremblay Annie M AM Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, - - 2014
The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here we report that YAP1 activity is elevated in human embryonal rhabdomyosarcoma (ERMS). In mice, sustained YAP1 hyperactivity in activated, but not quiescent, satellite cells induces ERMS with high penetrance and short latency. Via its ...
Elzein Samar S Departments of Experimental Medicine - - 2014
Human Growth Hormone (GH) binds to its receptor (GHR) on target cells and activates multiple intracellular pathways, leading to changes in gene expression, differentiation and metabolism. GHR deficiency is associated with growth and metabolic disorders while increased GHR expression has been reported in certain cancers, suggesting that the GHR gene ...
Huber Cristina C Institute of Immunology, University Hospital Bern, Inselspital, CH-3010, Bern, - - 2014
Receptor Activator of NF-κB Ligand (RANKL) is either expressed as surface (hRANKL1, hRANKL2) or soluble (hRANKL3) form. RANKL is involved in multifaceted processes of immunoregulation and bone resorption such as they occur in rheumatoid arthritis (RA). Interestingly, activated basophils, which are effector cells in allergic inflammation, contribute to the progress ...
Fjeldborg Karen K K Fjeldborg, Internal medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark - - 2014
CD163-positive macrophages are highly expressed in the human adipose tissue (AT) particularly from obese individuals. Little is, however, known about the regulation of CD163 mRNA and the protein level of sCD163 in human AT. We aimed to examine the regulation of CD163 and sCD163 in AT. Human subcutaneous AT samples ...
Azmahani Abdullah A Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan; Faculty of Medicine and Health Sciences, University Sultan Zainal Abidin, Kuala Terengganu, Terengganu, - - 2014
The sebaceous gland is a major site of steroid synthesis in human skin, but details of the status of steroidogenic enzymes and their regulation in human sebaceous glands under normal and pathological conditions have rarely been reported. Therefore, in this study, we examined the status of steroidogenic enzymes, sex steroid ...
Juarez Paloma - - 2014
The production of neutralizing immunoglobulin A (IgA) in edible fruits as means of oral passive immunization is a promising strategy for the inexpensive treatment of mucosal diseases. This approach is based on the assumption that the edible status remains unaltered in the immunoglobulin-expressing fruit, and therefore extensive purification is not ...
Nickless Andrew A Department of Cell Biology &Physiology, Washington University School of Medicine, St. Louis, Missouri, - - 2014
The nonsense-mediated mRNA decay (NMD) pathway selectively eliminates aberrant transcripts containing premature translation termination codons and regulates the levels of a number of physiological mRNAs. NMD modulates the clinical outcome of a variety of human diseases, including cancer and many genetic disorders, and may represent a target for therapeutic intervention. ...
Chang Hsun-Ming HM Department of Obstetrics and Gynaecology, Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z - - 2014
Context: Exerting a broad range of biological effects in various tissues, activins are homo- or heterodimers of activin/inhibin β subunits (βA, βB, βC and βE in humans). While activins A (βAβA), B (βBβB), AB (βAβB) and AC (βAβC) have been demonstrated in the female reproductive system, little is known about ...
Docanto Maria M MM Metabolism & Cancer Laboratory, MIMR-PHI Institute of Medical Research, Clayton, VIC, 3168, - - 2014
Aromatase converts androgens into estrogens and its expression within adipose stromal cells (ASCs) is believed to be the major driver of estrogen-dependent cancers in older women. Ghrelin is a gut-hormone that is involved in the regulation of appetite and known to bind to and activate the cognate ghrelin receptor, GHSR1a. ...
Kamisoglu Kubra K 1Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 2Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 3Department of Surgery, Rutgers - Robert Wood Johnson Medical School, New Brunswick, - - 2014
In this meta-study, we aimed to integrate biological insights gained from two levels of -omics analyses on the response to systemic inflammation induced by LPS in humans. We characterized the interplay between plasma metabolite compositions and transcriptional response of leukocytes through integration of transcriptomics with plasma metabonomics. We hypothesized that ...
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