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Results 201 - 250 of 3082
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Watanabe Hitoshi H Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, - - 2014
Human embryonic stem cells (hESCs) could provide a major window into human developmental biology, because the differentiation methods from hESCs mimic human embryogenesis. We previously reported that the overexpression of hematopoietically expressed homeobox (HHEX) in the hESC-derived definitive endoderm (DE) cells markedly promotes hepatic specification. However, it remains unclear how ...
Valencia-Quintana Rafael R Evaluación de Riesgos Ambientales, Facultad de Agrobiología, Universidad Autónoma de Tlaxcala Tlaxcala, - - 2014
The identification of aflatoxins as human carcinogens has stimulated extensive research efforts, which continue to the present, to assess potential health hazards resulting from contamination of the human food supply and to minimize exposure. The use of biomarkers that are mechanistically supported by toxicological studies will be important tools for ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0084883.].
Wessels Jocelyn M JM Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, - - 2014
The neurotrophins are neuropeptides that are potent regulators of neurite growth and survival. Although mainly studied in the brain and nervous system, recent reports have shown that neurotrophins are expressed in multiple target tissues and cell types throughout the body. Additionally, dysregulation of neurotrophins has been linked to several disease ...
Tang Qing-Feng QF Department of Clinical Laboratories & Experimental Center, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, - - 2014
A traditional Chinese medicine (TCM) formula, Zuo Jin Wan (ZJW), has been found as an anticancer drug in human cancer. In this study, we investigated the synergistic effect of ZJW extracts on DDP-induced apoptosis in human gastric cancer SGC-7901/DDP cells. Our results demonstrated that ZJW extracts could increase the sensitivity ...
Chatterjee Paulami P Department of Biophysics, Bose Institute, Acharya J.C. Bose Centenary Building, Kolkata, - - 2014
Parkinson's Disease (PD) is a progressive neurologic disorder that affects movement and balance. Recent studies have revealed the importance of microRNA (miR) in PD. However, the detailed role of miR and its regulation by Transcription Factor (TF) remain unexplored. In this work for the first time we have studied TF-miR-mRNA ...
Dullea Robert R 1 Cardiovascular and Metabolic Disease Research Unit, Pfizer , Cambridge, - - 2013
The cAMP response element binding protein (CREB)-regulated transcriptional coactivator 2 (CRTC2) is a key component of the transcription complex regulating glucagon driven hepatic glucose production and previous evidence suggests that "inhibition" of CRTC2 improves glucose homeostasis in multiple rodent models of type 2 diabetes. Here we describe a process of ...
Tan Dunyong D Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, 92521 -0121; College of Medicine/Institute of Medical Sciences, Jishou University, Jishou 416000, Hunan, PR - - 2013
We have identified a new variant of human Stat5a, found at higher ratios to full-length Stat5a in invasive ductal carcinoma versus contiguous normal tissue. The variant, missing exon 5, inhibits p21 and Bax production and increases cell number. After prolactin stimulation, only full-length Stat5a interacts with the vitamin D and ...
Gnemmi Viviane V Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Equipe 5 "Mucines, différenciation et cancérogenèse épithéliales", Jean-Pierre Aubert Research Center, Rue Michel Polonovski, 59045 Lille Cedex, France; Institute of Pathology, Centre de Biologie-Pathologie, CHRU de Lille, 2 avenue Oscar Lambret, 59037 Lille Cedex, France; Faculté de Médecine Henri-Warembourg, Université de Lille 2, F-59045 Lille, France. Electronic address: - - 2013
MUC1 is overexpressed in human carcinomas. The transcription factor SNAIL can activate epithelial-mesenchymal transition (EMT) in cancer cells. In this study, in renal carcinoma, we demonstrate that (i) MUC1 and SNAIL were overexpressed in human sarcomatoid carcinomas, (ii) SNAIL increased indirectly MUC1 expression, (iii) MUC1 overexpression induced EMT, (iv) MUC1 ...
Xu Hongguang H Department of Orthopedic Surgery, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui 241001, P.R. - - 2014
The aim of this study was to observe autophagy in chondrocytes from degenerative human cervical vertebral end-plates and to investigate the significance of variations in autophagy in the degeneration of cervical vertebral end-plate chondrocytes. Cartilage end-plates were obtained from 48 inpatients admitted to hospital between February 2011 and August 2012. ...
Morita Yoshihiro Y Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan; Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, Osaka, Japan; Department of Oral and Maxillofacial Surgery, Seichokai Hannan City Hospital, Hannan, - - 2013
This study aimed to determine the relationship of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor-c (VEGF-C) expression with lymphangiogenesis, lymph node metastasis (LNM), and other clinicopathologic features in human oral tongue cancers. Forty tongue cancer specimens were immunohistochemically examined for COX-2 and VEGF-C expression and for lymphatic vessel density (LVD). ...
Varma Saaket S 1Children's Hospital Los - - 2013
Chronic injury of alveolar lung epithelium leads to epithelial disintegrity in idiopathic pulmonary fibrosis (IPF). We had reported earlier that Grhl2, a transcriptional factor maintains alveolar epithelial cell integrity by directly regulating components of adherens and tight junctions and thus hypothesized an important role of GRHL2 in pathogenesis of IPF. ...
Li Zhonghan Z Program for RNA Biology, Sanford-Burnham Medical Research Institute, La Jolla, CA - - 2013
Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a variety of biological processes. Here, we used a custom microarray to identify lincRNAs associated with activation of the innate immune response. A panel of 159 lincRNAs was ...
Huang Xiaodong X Department of Pathology, Nantong University Cancer Hospital, Nantong, 226001, Jiangsu, People's Republic of - - 2013
Human hepatocellular carcinoma (HCC) is one of the most common fatal cancers and an important health problem worldwide, but its mechanism is still unclear. Microtubule (MT) kinesin motor proteins orchestrate a variety of cellular processes (e.g. mitosis, motility and organelle transportation) and have been involved in human carcinogenesis. KIF3B, the ...
Zhang Ao A Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, OH, 44195, USA, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA, Department of Human Genetics, Ann Arbor, MI 48109, USA, Cellular and Molecular Biology Program, Ann Arbor, MI 48109, USA, Department of Internal Medicine, Ann Arbor, MI 48109, USA and Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan, 48109, - - 2013
Retrotransposons are mobile genetic elements, and their mobility can lead to genomic instability. Retrotransposon insertions are associated with a diverse range of sporadic diseases, including cancer. Thus, it is not a surprise that multiple host defense mechanisms suppress retrotransposition. The 2',5'-oligoadenylate (2-5A) synthetase (OAS)-RNase L system is a mechanism for ...
Verma Rewa R Department of Biological Science, Gachon University, Incheon, 406-799, - - 2013
In humans, there are ten toll-like receptors (TLRs), among which TLR10 is the only orphan receptor whose function is unknown. In this study, we examined the effects of IFN-γ, LPS and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on TLR10 expression of human monocyte THP-1 and compared them with those of other surface TLRs ...
Liu Xuebing X Department of Otolaryngology Head and Neck Surgery, the Second Hospital of Tianjin Medical University, Tianjin, - - 2013
Nasopharyngeal carcinoma (NPC) is one of the most common cancers originating in the nasopharynx, and chemoresistance is an essential aspect of NPC chemotherapy failure. Sorcin has been implicated in multidrug resistance (MDR) of many types of human tumor. However, the effect and mechanism of Sorcin in MDR of human NPC ...
Takasaka Naoki N Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105-8461, - - 2013
Cigarette smoke (CS)-induced cellular senescence has been implicated in the pathogenesis of chronic obstructive pulmonary disease, and SIRT6, a histone deacetylase, antagonizes this senescence, presumably through the attenuation of insulin-like growth factor (IGF)-Akt signaling. Autophagy controls cellular senescence by eliminating damaged cellular components and is negatively regulated by IGF-Akt signaling ...
Ohlsson Ewa E The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences; 2 Biotech Research and Innovation Center (BRIC); 3 Danish Stem Cell Centre (DanStem) Faculty of Health Sciences; 4 The Bioinformatic Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, 2200 Copenhagen, - - 2013
MLL-fusion proteins are potent inducers of oncogenic transformation, and their expression is considered to be the main oncogenic driving force in ∼10% of human acute myeloid leukemia (AML) patients. These oncogenic fusion proteins are responsible for the initiation of a downstream transcriptional program leading to the expression of factors such ...
Xiao Heng H 1] Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China [2] Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, - - 2013
Bcl2-associated athanogene 3 (BAG3) protein is a co-chaperone of heat-shock protein (Hsp) 70 and may regulate major physiological and pathophysiological processes. However, few reports have examined the role of BAG3 in human hepatocellular carcinoma (HCC). In this study, we show that BAG3 regulates epithelial-mesenchymal transition (EMT) and angiogenesis in HCC. ...
McLoughlin Hayley S HS Department of Internal Medicine, Neurology, and Physiology & Biophysics, and the Interdisciplinary Graduate Program in University of Iowa, Iowa City, IA, - - 2013
MicroRNAs (miRNAs) have been established as important negative post-transcriptional regulators for gene expression. Within the past decade miRNAs targeting transcription factors (TFs) has emerged as an important mechanism for gene expression regulation. Here, we tested the hypothesis that in TF 3'UTRs, the human-specific single nucleotide change(s) that create novel miRNA ...
Taylor Patricia R PR Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, - - 2014
Here we identified a population of bone marrow neutrophils that constitutively expressed the transcription factor RORγt and produced and responded to interleukin 17A (IL-17A (IL-17)). IL-6, IL-23 and RORγt, but not T cells or natural killer (NK) cells, were required for IL-17 production in neutrophils. IL-6 and IL-23 induced expression ...
Park J K JK Department of Obstetrics and Gynecology, School of Medicine, Gyeongsang National University, JinJu, South Korea; Institute of Health Sciences, School of Medicine, Gyeongsang National University, JinJu, South - - 2013
We investigated the expression of heat shock protein 70 (Hsp70), nuclear factor of activated T cells 5 (NFAT5), and hypoxia-induced factor-1α (HIF-1α) in the placentas of normal and preeclamptic pregnancies and in human placental hypoxia models in vitro to examine the regulatory mechanisms of placental Hsp70 expression. The expression levels of ...
Zheng Tongsen T 1] Department of Pediatrics, Rutgers Cancer Institute of New Jersey, Rutgers State University of New Jersey, New Brunswick, New Jersey 08903, USA [2] Key laboratory of Hepatosplenic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150086, China - - 2013
The tumour suppressor p53 is frequently mutated in tumours. Mutant p53 (Mutp53) proteins often gain new activities in promoting tumorigenesis, defined as gain-of-function (GOF). Mutp53 can accumulate to high levels in tumours, which promotes mutp53 GOF in tumorigenesis. The mechanism of mutp53 accumulation is poorly understood. Here we find that ...
Schlottmann I I Medical Clinic III, Dresden University of Technology, - - 2013
Background:Fatty acid binding protein 4 (FABP4) is a predominantly cytosolic protein of adipocytes, but also abundantly present in human plasma; its plasma concentrations were linked to obesity and metabolic syndrome. Recent studies have suggested a direct extracellular effect of FABP4 in the regulation of glucose metabolism and heart function independently ...
De Bellis Manuela M Department of Bioscience, Biotechnologies and Biopharmaceutics and Center of Excellence in Comparative Genomics (CEGBA), University of Bari "Aldo Moro", 70126 Bari, Italy M. Sarcone Hospital, - - 2013
Two major isoforms of Aquaporin-4 (AQP4) have been described in human tissue. Here we report the identification and functional analysis of an alternatively spliced transcript of human AQP4, AQP4-Δ4, that lacks exon 4. In transfected cells AQP4-Δ4 is mainly retained in the ER and shows no water transport properties. When ...
Masse Ingrid I Université de Lyon, 69003, Lyon, France, - - 2013
GATA3 belongs to the GATA transcription factor family and is a crucial regulator of lymphocyte differentiation. More recently, GATA3 was shown to be involved in skin cell lineage determination, in morphogenesis and maintenance of hair follicle keratinocytes as well as in epidermal barrier formation in mouse. In human, the potential ...
Gowrishankar Banumathy B Cancer Epigenetics Program; Fox Chase Cancer Center; Philadelphia, PA - - 2013
Clear cell RCC is the most common, and more likely to metastasize, of the three main histological types of RCC. Pathologic stage is the most important prognostic indicator and nuclear grade can predict outcome within stages of localized RCC. Epithelial tumors are thought to accumulate a series of genetic and ...
Long Justin M JM Indiana University School of Medicine, United - - 2013
Alzheimer's disease (AD) results, in part, from the excess accumulation of the amyloid-β (Aβ) peptide as neuritic plaques in the brain. The short Aβ peptide is derived from the large transmembrane Aβ precursor protein (APP). The rate limiting step in the production of Aβ from APP is mediated by the ...
Sibbons Charlene M CM Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, - - 2013
Female humans and rodents have been shown to have higher 22:6n-3 status and synthesis than males. It is unclear which sex hormone is involved. We investigated the specificity of the effects of physiological concentrations of sex hormones in vitro on the mRNA expression of genes involved in polyunsaturated fatty acid ...
Noyola-Martínez Nancy N Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Tlalpan 14000, México, D.F., - - 2013
Placenta is an important source of endocrine and immunological factors. During pregnancy, calcitriol, the active metabolite of vitamin D, is also metabolized by decidua and placental tissue by means of CYP27B1 and CYP24A1 for synthesis and inactivation of calcitriol respectively. Calcitriol production is regulated by several factors in a tissue-specific ...
Son Eui Dong ED AmorePacific Corp/R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-do, Republic of - - 2013
Staphylococcus aureus (S. aureus) is found on the skin of approximately 90% of patients with atopic dermatitis and approximately 20% of apparently healthy subjects. S. aureus induces keratinocytes and immune cells to secrete immunoregulatory factors that cause epidermal barrier dysfunction in atopic skin. This study examined factors that cause epidermal ...
Magistri Paolo P Division of Surgical Oncology, Department of Surgery, Moores UCSD Cancer Center, University of California, San Diego, California; Faculty of Medicine and Psychology, Azienda Ospedaliera Sant'Andrea, Sapienza-Università di Roma, Rome, - - 2013
Hepatocellular carcinoma (HCC) frequently represents two diseases as it often arises in the setting of cirrhosis caused by the proliferation and activation of hepatic stellate cells (HSCs). Previously, we identified that Hedgehog (Hh) signaling regulates HSC viability and fibrinogenesis, as well as HCC tumorigenesis. Although it is increasingly recognized that ...
Morales-Prieto D M DM University Hospital Jena, Department of Obstetrics, Placenta-Lab, Bachstraße. 18, 07743 Jena, Germany. Electronic address: - - 2013
MicroRNAs (miRNAs) regulate the expression of a large number of genes in plants and animals. Placental miRNAs appeared late in evolution and can be found only in mammals. Nevertheless, these miRNAs are constantly under evolutionary pressure. As a consequence, miRNA sequences and their mRNA targets may differ between species, and ...
Sumita Kazutaka K University of Cincinnati, United - - 2013
Mammalian cells encode three closely related Ras proteins, H-Ras, N-Ras, and K-Ras. Oncogenic K-Ras mutations frequently occur in human cancers, which lead to dysregulated cell proliferation and genomic instability. However, mechanistic role of the Ras isoform regulation have remained largely unknown. Furthermore, the dynamics and function of negative regulation of ...
Murano Tatsuro T Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, - - 2013
Notch signaling plays an essential role in the proliferation and differentiation of intestinal epithelial cells (IECs). We have previously shown that Notch signaling is up-regulated in the inflamed mucosa of ulcerative colitis (UC) and thereby plays an indispensable role in tissue regeneration. Here we show that in addition to Notch ...
Bhattacharyya Sumit S a Department of Medicine , University of Illinois at Chicago , Chicago , Illinois , - - 2013
Exposure to the common food additive carrageenan was previously associated with increased Wnt9A expression and increased cytoplasmic β-catenin in human colonic epithelial cells. In this report, exposure of human colonic epithelial cells in culture and of mouse colonic epithelium in vivo to low concentrations of carrageenan is shown to activate ...
Hosur Raghavendra R Patient Stratification group, Biogen Idec, Cambridge, - - 2013
Transcriptional profiling still remains one of the most popular techniques for identifying relevant biomarkers in patient samples. However, heterogeneity in the population leads to poor statistical evidence for selection of most relevant biomarkers to pursue. In particular, human transcriptional differences can be very subtle, making it very difficult to tease ...
Ying Xiaozhou X Department of Orthopaedic Surgery, The Second Affiliated Hospital of Wenzhou Medical College, 109 Xue yuan xi Road, Wenzhou, 325000, China, - - 2013
Cordycepin, a nucleoside derivative isolated from Cordyceps, has been reported to exert anti-inflammatory, antitumor, antidiabetic and renoprotective effects. Osteoarthritis (OA) is a degenerative joint disease with an inflammatory component that drives the degradation of cartilage extracellular matrix. This study aimed to assess the effects of cordycepin on human OA chondrocytes. ...
Rondini Elizabeth A EA Wayne State - - 2013
Cytosolic sulfotransferases (SULTs) catalyze the sulfate conjugation of a myriad of endogenous and xenobiotic substrates. Among the 13 human SULTs, little is known regarding regulation of the SULT1C subfamily. We evaluated the effects of a panel of transcription factor activators on levels of SULT1C mRNA (1C2 and 1C3) and protein ...
Duniec-Dmuchowski Zofia Z Wayne State - - 2013
The SULT1C3 gene was identified by computational analysis of the human genome and suggested to contain duplications of its last two exons (7a/b and 8a/b). Although the SULT1C3 isoform containing the more downstream exons 7b and 8b (SULT1C3d) has been expressed in E. coli, crystallized, and characterized for activity, there ...
Lilja-Maula L L Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, P.O. Box 57, University of Helsinki, 00014, Finland. Electronic address: - - 2013
Activation of transforming growth factor (TGF)-β is a key event in the progression of fibrosis in human lung tissue. Idiopathic pulmonary fibrosis (IPF) in West Highland white terriers (WHWTs) shares histopathological features of human usual interstitial pneumonia (UIP), the histopathological counterpart of IPF and non-specific interstitial pneumonia (NSIP). The aim of ...
Guariniello Stefano S Biochemistry, Biophysics and General Pathology Department, Second University of Naples, Naples, - - 2013
In humans we know 25 selenoproteins that play important roles in redox regulation, detoxification, immune-system protection and viral suppression. In particular, selenoprotein M (SelM) may function as thiol disulfide oxidoreductase that participates in the formation of disulfide bonds, and can be implicated in calcium responses. However, it presents a redox ...
Zhou Yan - - 2013
Berberine (BBR) is an isoquinoline alkaloid isolated from several Chinese herbal medicines, such as Coptis chinensis, Berberis aristata, and Coptis japonica. It exhibits a lipid-lowering effect by up-regulating hepatic low density lipoprotein receptor (LDLR) expression. However, the plasma concentration of BBR is very low after oral administration for the reason ...
Miyata Masaaki - - 2013
Sterol regulatory element-binding protein-2 (SREBP-2) is a basic helix-loop-helix-leucine zipper transcription factor that positively regulates transcription of target genes involved in cholesterol metabolism. In the present study, we have investigated a possible involvement of SREBP-2 in human intestinal expression of fibroblast growth factor (FGF)19, which is an endocrine hormone involved ...
Bjørnstad Sigrid S Department of Pathology, Oslo University Hospital HF, Ullevål, Oslo, - - 2013
Background: Antenatal corticosteroids and surfactant replacement therapy have dramatically reduced mortality caused by lung disease in premature babies. Knowledge about mechanisms regulating epithelial differentiation of the respiratory membrane is limited, as are effects of pharmacological interventions. The chicken fetus is a valuable model for exploring pharmacological actions on developing organs. ...
Jones H H The Center for Cellular and Molecular Fetal Therapy, Division of Pediatric General, Thoracic and Fetal Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: - - 2013
Previous work in our laboratory demonstrated that over-expression of human insulin-like growth factor-11 (hIGF-1) in the placenta corrects fetal weight deficits in mouse, rat, and rabbit models of intrauterine growth restriction without changes in placental weight. The underlying mechanisms of this effect have not been elucidated. To investigate the effect ...
Mohsen-Kanson Tala - - 2013
Identification of molecular mechanisms involved in generation of different types of adipocytes is progressing substantially in mice. However, much less is known regarding characterization of brown and white adipocyte progenitors (APs) in humans, highlighting the need for an in vitro model of human adipocyte development. Here we report a procedure ...
Su Shengzhong - - 2013
Microsomal epoxide hydrolase (mEH, EPHX1) is a critical biotransformation enzyme, catalyzing the metabolism of many xenobiotics. Human mEH is transcribed using alternative promoters. The proximal E1 promoter is active in liver while the far upstream E1b promoter drives the expression of mEH in all tissues including liver. Although several liver-specific ...
Huang Hsiao-Ning HN Genomics Research Center, Academia Sinica, Taipei, Taiwan; Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, - - 2013
Human embryonic stem cells (hESCs) are functionally unique for their self-renewal ability and pluripotency, but the molecular mechanisms giving rise to these properties are not fully understood. hESCs can differentiate into embryoid bodies (EBs) containing ectoderm, mesoderm, and endoderm. In the miR-200 family, miR-200c was especially enriched in undifferentiated hESCs ...
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