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Liu Wanqing W Department of Medicine and Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907 - - 2014
The aim of this study was to discover cis- and trans-acting factors significantly affecting mRNA expression and catalytic activity of human hepatic UDP-glucuronosyltransferases (UGTs). Transcription levels of 5 major hepatic UGT1A (UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9) and 5 UGT2B (UGT2B4, UGT2B7, UGT2B10, UGT2B15 and UGT2B17) genes were quantified in ...
Reiser Peter J PJ Ohio State University - - 2014
Mammalian hearts express two myosin heavy chain (MHC) isoforms, which drive contractions with different kinetics and power-generating ability. The expression of the isoform that is associated with more rapid contraction kinetics and greater power output, MHC-α, is down-regulated, with a concurrent increase in the relative amount of the slower isoform, ...
Fu Houju H Department of Obstetrics and Gynecology, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113 8655 - - 2014
SIRT3 is a member of the sirtuin family and has recently emerged as a vital molecule in controlling the generation of reactive oxygen species (ROS) in oocytes. Appropriate levels of ROS play pivotal roles in human reproductive medicine. The present study aimed to investigate SIRT3 expression and analyze the SIRT3-mediated ...
Choi Young-Ae - - 2014
Transcription factors have been implicated in regulating the differentiation of odontoblasts from dental pulp stem cells/progenitors (DPSCs/progenitors), but their regulatory network is not completely understood.Result: New transcription factors that control the odontoblast differentiation of human DPSCs/progenitors were analyzed using a microarray. The result revealed bobby sox homolog (BBX) to be ...
Guo W L WL Department of Radiology, The Children's Hospital Affiliated to Soochow University, Suzhou, - - 2014
β-catenin and c-myc play important roles in the development of tissues and organs. However, little is known about their expression patterns during the development of the human common bile duct. Immunohistochemistry was used to detect β-catenin and c-myc expression in common bile duct samples from postmortem tissues of 14 premature ...
McIntosh Avery L AL Texas A&M - - 2014
Although human liver fatty acid binding protein (FABP1) T94A variant has been associated with non-alcoholic fatty liver disease (NAFLD) and reduced ability of fenofibrate to lower serum triglycerides (TG) to target levels, molecular events leading to this phenotype are poorly understood. Cultured primary hepatocytes from female human subjects expressing the ...
Tahir Raiha R Center of the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, USA, - - 2014
Retinoic acid induced-1 (RAI1) is an important yet understudied histone code reader that when mutated in humans results in Smith-Magenis syndrome (SMS), a neurobehavioral disorder accompanied by signature craniofacial abnormalities. Despite previous studies in mouse and human cell models, very little is known about the function of RAI1 during embryonic ...
Li Chenghua - - 2014
Periodontitis is initiated and sustained by bacteria. However, the mechanism of bacteria induced periodontitis is still unknown. We hypothesized that bacterial components can affect the functions of stem cells in the periodontium. In this study, we comparatively investigated the influence of Lipopolysaccharide (LPS) on the osteogenesis potential of human periodontal ...
Sandey Maninder M Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, AL, - - 2014
Human melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) displays potent growth suppressing and cell killing activity against a wide variety of human and rodent cancer cells. In this study, we identified a canine ortholog of the human mda-7/IL-24 gene located within a cluster of IL-10 family members on chromosome 7. The full-length ...
Wang Ying Y Y Wang, Institute of Obstetrics & Gynecology, Fudan Uiversity Shanghai Medical College, Shanghai, - - 2014
Mammalian proprotein convertases (PCs) play an important role in folliculogenesis, as they proteolytically activate a variety of substrates such as the transforming growth factor-beta (TGF-β) superfamily. Proprotein convertase subtilism/kexin (PCSK) 6 is a member of the PC family and is ubiquitously expressed and implicated in many physiological and pathological processes. ...
Akiyama Toshihiro T Department of Dermatology, Juntendo University Graduate School of Medicine, Tokyo, - - 2014
Both psoriasis and atopic dermatitis (AD) are not only associated with an impaired stratum corneum barrier, but also with abnormal expression of the tight junction (TJ) proteins. Because host defense peptides, including LL-37, are overexpressed in lesional psoriatic skin but are downregulated in lesional AD skin, we hypothesized that LL-37 ...
Zhang Y Y Department of Periodontology, Tianjin Stomatological Hospital, Tianjin, - - 2014
Lipopolysaccharide (LPS) on the cell wall of periodontal pathogens is a major mediator of the inflammatory response and can enhance alveolar bone resorption in periodontitis. Bone sialoprotein is an early marker of osteoblast differentiation. The proinflammatory cytokine, interleukin-8 (IL-8), induces osteoclast differentiation, maturation and maintenance of bone resorption activity. However, ...
Chiang Kun-Chun KC General Surgery Department, Chang Gung Memorial Hospital, Keelung, Taiwan, - - 2014
Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer. Vitamin D, a pro-hormone, is getting popular due to its hormone-like functions after converted to its active form, 1α,25(OH)2D3. Here, we show that dietary supplementation with 6 IU/g of vitamin D greatly suppressed ICC initiation and progression without apparent toxicity in a chemically ...
Bjerkan L L Department of Oral Biology, Dental Faculty, University of Oslo, Oslo, - - 2014
Thymic stromal lymphopoietin (TSLP) has multifaceted immunological functions ranging from maintenance of tolerance to induction of disease. Two human transcript variants of TSLP are described: a long form (variant 1; lfTSLP) consisting of four exons and an alternative, short form (variant 2; sfTSLP) that lacks two exons compared with variant ...
Liao Ming-Huei MH Department of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, - - 2014
Skin fibroblasts modulate tissue repair, wound healing and immunological responses. Adrenergic receptors (ARs) mediate important physiological functions, such as endocrine, metabolic and neuronal activity. In this study, the expression α1A-ARs in human skin fibroblasts is examined and verified. Regulatory effects of α1-agonist cirazoline on cell migration and the production of ...
Liang Weiguo W Guangzhou Institute of Traumatic Surgery, the Fourth Affiliated Hospital of Medical College, Jinan University, Guangzhou, China 510220. Electronic address: - - 2014
Extracellular-signal-regulated kinase 5 (ERK5) is a member of the mitogen-activated protein kinase (MAPK) family and regulates a wide variety of cellular processes such as proliferation, differentiation, necrosis, apoptosis and degeneration. However, the expression of ERK5 and its role in degenerated human nucleus pulposus (NP) is hitherto unknown. In this study, ...
Schneider Marlon R MR Institute for Biotechnology and Molecular Animal Breeding, The Gene Center, University of Munich, Munich, - - 2014
The cell adhesion molecule E-cadherin has critical functions in development and carcinogenesis. Impaired expression of E-cadherin has been associated with disrupted tissue homeostasis, progression of cancer and a worse patient prognosis. So far, the role of E-cadherin in homeostasis and carcinogenesis of the liver is not well understood. By use ...
Yamana Hidenori H Department of Physiology, Osaka Medical College, Takatsuki 569-8686, Japan; Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki 569-8686, - - 2014
Mouse monocyte/macrophage MHC receptor 1 (MMR1; or MMR2) specific for H-2D(d) (or H-2K(d) ) molecules is expressed on monocytes from non-H-2D(d) (or non-H-2K(d) ), but not those from H-2D(d) (or H-2K(d) ), in-bred mice. The MMR1 and/or MMR2 is essential for the rejection of H-2D(d) - and/or H-2K(d) -transgenic mouse ...
El Mansouri Fatima Ezzahra - - 2014
Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE2, a critical mediator in the pathophysiology of osteoarthritis (OA). Histone methylation plays an important role in epigenetic gene regulation. In this study, we investigated the roles of histone H3 (H3K9) methylation in interleukin-1beta (IL-1beta)-induced mPGES-1 expression ...
Zis Odysseus O Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, Graduate Program in Neuroscience, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, - - 2014
The macrophage migration inhibitory factor (MIF) is a multifaceted cytokine involved in many processes, including cellular responses to ischemia/reperfusion injury in the heart and brain. This study was undertaken to determine whether human MIF expression is induced following cerebral ischemia and its role therein. To examine whether the induction of ...
Wang Minghao M Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, 11001, People's Republic of - - 2014
Previous study indicated diversin overexpression in human cancers. However, its expression pattern in human gliomas and the molecular mechanisms of diversin on cancer progression have not been characterized. In the present study, diversin expression was investigated in 105 glioma specimens using immunohistochemistry. Negative staining was observed in normal glial cells, ...
No Yi Ran YR Emory University, United - - 2014
Na+/H+ exchanger NHE3 expressed in the intestine and kidney plays a major role in NaCl and HCO3- absorption that is closely linked to fluid absorption and blood pressure regulation. The Nedd4 family of E3 ubiquitin ligases interacts with a number of transporters and channels via PY motifs. A comparison of ...
Tokudome Yoshihiro Y a Laboratory of Dermatological Physiology, Faculty of Pharmaceutical Sciences , Josai University , Sakado , - - 2014
Low molecular weight soybean peptide (LSP) was applied to normal human epidermal keratinocytes, and the results showed a significant increase in the gene expression levels of involucrin, transglutaminase, and profilaggrin. Filaggrin protein levels were also significantly higher. It is possible that LSP has an epidermal cell differentiation-promoting effect and may ...
Simó Rafael R Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, - - 2014
Epidemiological studies have shown that plasma SHBG levels correlate with plasma adiponectin levels, both in men and women. There are no reports describing any molecular mechanism by which adiponectin regulates hepatic SHBG production. The aim of the present study is to explore whether adiponectin regulates SHBG production by increasing HNF-4α ...
Barzilay Eran E IVF Unit, Human Embryonic Stem Cell and Reproduction Lab, Department of Obstetrics and Gynecology, Sheba Medical Center , Tel-Hashomer , Israel (affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, - - 2014
Abstract Poliovirus receptor (PVR), regulator of G-protein signaling-11 (RGS11), and erythrocyte protein band-4.1-like 3 (EPB41L3) have been proposed to function in follicular maturation in mouse models. We have examined their expression in human mural (mGCs) and cumulus granulosa cells (CCs). Expression of PVR and RGS11 in mGCs decreased in medium-sized ...
Ramot Yuval Y Department of Dermatology, Hadassah - Hebrew University Medical Center, Jerusalem, - - 2014
Human skin produces numerous neurohormones and neuropeptides. Recent evidence has shown that the neuroendocrine regulation of human skin biology also extends to keratins, the major structural components of epithelial cells. For example, thyrotropin-releasing hormone, thyrotropin, opioids, prolactin, and cannabinoid receptor 1-ligands profoundly modulate human keratin gene and protein expression in ...
Scotchie Jessica G JG 1Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, - - 2014
Humans produce endogenous cannabinoids (endocannabinoids), a group of molecules that activate the same receptors as tetrahydrocannabinol. Endocannabinoids play important roles in reproduction in multiple species, but data in human endometrium are limited. Because endocannabinoids such as anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) often act within tissues as paracrine factors, their ...
Lee S-I SI Department of Dental Hygiene, School of Health Science, Dankook University, Cheonan, Republic of - - 2014
The precise regulation of odontoblast differentiation and osteoclastogenic cytokine expression in human dental pulp cells (HDPCs) is crucial for the pathology of bacteria-related pulpitis. Although the up-regulation of nucleotide-binding oligomerization domain-containing protein 2 (NOD2) has been reported in inflamed human dental pulps, the role of NOD2 in the differentiation of ...
Oda Yuki Y Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, - - 2014
Retinoid X receptor α (RXRα) forms a heterodimer with numerous nuclear receptors to regulate drug- or lipid-metabolizing enzymes. In this study, we investigated whether human RXRα is regulated by microRNAs. Two potential recognition elements of miR-34a were identified in the RXRα mRNA: one in the coding region and the other ...
Mrosewski I I Department for Orthopaedic, Trauma and Reconstructive Surgery, Charité-University of Medicine, Campus Benjamin Franklin, FEM Garystrasse 5, 14195, Berlin, - - 2014
Synovial fibroblasts (SF) contribute to the pathogenesis of osteoarthritis (OA), but the effects of intra-articular cytokines on SF are not completely understood. The aim of this study was to characterize the interplay between tumor necrosis factor (TNF)α and the anti-inflammatory interleukin (IL)-10. Non-immortalized human SF and SF of the human ...
Dou Wei W Shanghai Key Laboratory of Complex Prescription and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, - - 2014
Isorhamnetin is an O-methylated flavonol present in fruit and vegetables. We recently reported the identification of isorhamnetin as an activator of the human pregnane X receptor (PXR), a known target for abrogating inflammation in inflammatory bowel disease (IBD). The current study investigated the role of isorhamnetin as a putative mouse ...
Zhang Zhiyong Z Department of Hepatobiliary Surgery, Shaanxi Provincial People's Hospital, Youyi Xi Road 256#, Xi'an, 710068, Shaanxi, China, - - 2014
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. MicroRNA-148a (miR-148a) has recently been found to be involved in many critical processes in human malignancies. The present study is to clarify the expression pattern and prognostic role of miR-148b in ...
Luo Daochun - - 2014
BOK (BCL2-related ovarian killer) is a member of the pro-apoptotic BCL2 family that is highly expressed in the human placenta. BOK excess causes increased trophoblast autophagy and apoptosis in preeclampsia, a pathologic condition of hypoxia and oxidative stress. In this study, we identified a hypoxia-response element (HRE) at the junction ...
Hinton Andrew A Pediatric Diabetes Research Center, University of California, SanDiego, La Jolla, CA, 92121, - - 2014
MicroRNAs (miRNAs) are noncoding, regulatory RNAs expressed dynamically during differentiation of human embryonic stem cells (hESC) into defined lineages. Mapping developmental expression of miRNAs during transition from pluripotency to definitive endoderm (DE) should help to elucidate the mechanisms underlying lineage specification and ultimately enhance differentiation protocols. In this report, next ...
Cominelli Antoine - - 2014
Matrix metalloproteinases (MMPs) are key enzymes involved in extracellular matrix remodelling. In the human endometrium, the expression and activity of several MMPs are maximal during the menstrual phase. Moreover, MMPs are thought to be involved in the pathogenesis of endometriosis and cancers, in particular with invasion and metastasis. We recently ...
Liu Bin B Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, People's Republic of China; Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8527, - - 2014
High-mobility group AT-hook protein 2 (HMGA2) is an architectural transcription factor associated with malignancy, invasiveness, and poor prognosis in a variety of human neoplasms. This study investigated HMGA2 expression and prognostic value in human gliomas. We also correlated HMGA2 expression with Ki-67 labeling index and matrix metalloproteinase-2. Expression of HMGA2 ...
Zhang Jun-Qing JQ Department of Oncology, the 264th Hospital of PLA, Taiyuan, 030001, - - 2014
Our aim was to investigate the expression of micro-RNA-200b (miR-200b) and cAMP-responsive element-binding protein 1 (CREB-1) in astrocytoma and its efficacy for predicting outcome. Both miR-200b and CREB-1 messenger RNA expression was measured in 122 astrocytomas and 30 nonneoplastic brain specimens by quantitative real-time polymerase chain reaction. Expression of miR-200b ...
Avitabile Daniele D Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Medicina Clinica e Molecolare, Sapienza Università di Roma, Italy; Laboratiorio Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino - IRCCS, Milan, Italy. Electronic address: - - 2014
Circadian rhythms are highly conserved time tracking systems regulating important biological processes at both systemic and cellular levels. The present study was aimed to identify proteins and biological functions circadian regulated in human keratinocytes. HaCaT keratinocytes were entrained by temperature cycles, and a proteomic study was performed on cell fractions ...
Wang Bo B Department of Anatomy and Developmental Biology, Monash University, Victoria, - - 2014
MicroRNAs (miRNAs) are small non-coding RNAs that are critical regulators of gene expression at the post-transcriptional level. The miRNAs constitute an abundant class of RNAs conserved from plants to animals, and as such, play key roles in diverse biological processes including inflammation, development, differentiation and apoptosis. More recently it has ...
Bhinge Akshay A Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore City, - - 2014
Several transcription factors (TFs) have been implicated in neuroectoderm (NE) development, and recently, the TF PAX6 was shown to be critical for human NE specification. However, microRNA networks regulating human NE development have been poorly documented. We hypothesized that microRNAs activated by PAX6 should promote NE development. Using a genomics ...
Park Kio K Department of Dermatology, Yamato Takada Municipal Hospital, Nara, Japan; Department of Dermatology, Nara Medical University, Nara, Japan. Electronic address: - - 2014
Epidermal growth factor receptor inhibitors (EGFRIs) have developed as one of the potential treatment options for various kinds of cancers. Although a variety of dermatological adverse reactions such as follicular acneiform eruptions is commonly encountered, the mechanism of the reactions remains unclear. We investigated the effects of EGFRIs on the ...
Kasamatsu Shinya S Biological Science Laboratories, Kao Corporation, Haga, Tochigi, 321-3497, - - 2014
The signaling of stem cell factor (SCF) through its receptor Kit is known to play an important role in regulating cutaneous melanogenesis. In the course of UVB-induced pigmentation, the expression of membrane-bound SCF by epidermal keratinocytes is upregulated at an early phase and subsequently activates neighboring melanocytes via their Kit ...
Chang-Chien Ju J Department of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan; Institute of Microbiology & Immunology, College of Medicine, Chung Shan Medical University, Taichung, - - 2014
The intercellular gap junction channels formed by connexins (CXs) are important for recycling potassium ions in the inner ear. CXs are encoded by a family of the CX gene, such as GJB2, and the mechanism leading to mutant connexin-associated diseases, including hearing loss, remains to be elucidated. In this study, ...
Chen Jia - - 2014
Gastric carcinoma (GC) is a common and lethal malignancy, and epithelial-mesenchymal transition (EMT) is believed to contribute to invasive and metastatic tumor growth. Aquaporin 3 (AQP3) is overexpressed in human GC tissues, while human epidermal growth factor (EGF) and hepatocyte growth factor, which can induce EMT, are able to up-regulate ...
Mao Yi-Wen - - 2014
Uraria crinita is an edible herb used as a natural food in childhood skeletal dysplasia. Ethyl acetate, n-butanol, and aqueous fractions of a 95% ethanol crude extract of U. crinita were obtained and the active ingredients isolated and purified using a bio-guided method. In this manner, we isolated and identified ...
Breuker Cyril C Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France; Service de Pharmacie, Centre Hospitalier Universitaire Lapeyronie, Montpellier, - - 2014
The nuclear receptor Pregnane X Receptor (PXR, NR1I2) plays a pivotal role in xenobiotic metabolism. Here, we sought to characterize a new PXR isoform (hereafter called small PXR or sPXR) stemming from alternative transcription starting sites downstream from a CpG Island located near exon 3 of the human PXR gene. ...
Li Ning N Public Health School, Zhengzhou University, Zhengzhou, China; Henan Agriculture University, Zhengzhou, - - 2014
Chondrocyte proliferation and differentiation is a fundamental process during hard palatogenesis. Excessive retinoic acid (RA), the biologically most active metabolite of vitamin A, has been reported to adversely affect chondrogenesis. The aim of this study was to investigate the mechanisms underlying RA-induced chondrocyte differentiation by using human fetal palatal chondrocytes ...
Xu Guangfeng G Department of Laboratory Medicine, The 82nd Hospital of The People's Liberation Army, Huaian, Jiangsu 223001, P.R. - - 2014
MicroRNAs (miRNAs) are short non-coding RNAs that are involved in numerous biological processes, including obesity and insulin resistance. miR-26b is an obesity-related intronic miRNA located in the intron of the carboxy‑terminal domain, RNA polymerase II, polypeptide A, small phosphatase 1 gene. miR-26b is abundantly expressed in mice and mature human adipocytes, ...
Macglashan D D Jr Johns Hopkins Asthma and Allergy Center, Baltimore, MD, - - 2014
CD32b has been previously demonstrated to modulate IgE-mediated secretion from human basophils. However, exploration of the implications of this regulation has been limited. One unstudied area is whether regulation of signalling by CD32 also alters some of the phenotypic changes induced by IgE-mediated activation. The reported character of CD32-mediated signal ...
Okada Hidetaka H Department of Obstetrics and Gynecology, Kansai Medical University, Hirakata, Osaka, - - 2014
The human endometrium is a dynamic tissue that undergoes regular cycles of menstruation, menstrual repair, proliferation and secretory differentiation in response to hypoxia and the female sex hormones. We identified new target genes that are regulated by progesterone during the decidualization of human endometrial stromal cells (ESC), including interleukin-15 (IL-15), ...
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