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Papanikolaou Nikolaos A - - 2014
BackgroundAdaptation to stress is critical for survival. The adrenal medulla, the major source of epinephrine, plays an important role in the development of the hyperadenergic state and increased risk for stress associated disorders, such as hypertension and myocardial infarction. The transcription factor Egr1 plays a central role in acute and ...
Baeza-Montañez Lourdes L IHSM, CSIC, Crop Protection, Algarrobo-Costa, Malaga, Spain ; - - 2014
Ustilago maydis, causal agent of corn smut, can proliferate saprobically in a yeast form but its infectious filamentous form is an obligate parasite. Previously we showed that Ust1, the first APSES transcription factor functionally characterized in the Basidiomycota, controlled morphogenesis and virulence in this species. Here we further analyzed Ust1 ...
Wu Haijia H Abteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen, 37077 Göttingen, - - 2014
Telomerases protect the ends of linear chromosomes from shortening. They are composed of an RNA (TLC1 in S. cerevisiae) and several proteins. TLC1 undergoes several maturation steps before it is exported into the cytoplasm to recruit the Est proteins for complete assembly. The mature telomerase is subsequently reimported into the nucleus, ...
Donnelly Neysan N Group Maintenance of Genome Stability, Max Planck Institute of Biochemistry, Martinsried, - - 2014
Aneuploidy is a hallmark of cancer and is associated with malignancy and poor prognosis. Recent studies have revealed that aneuploidy inhibits proliferation, causes distinct alterations in the transcriptome and proteome and disturbs cellular proteostasis. However, the molecular mechanisms underlying the changes in gene expression and the impairment of proteostasis are ...
Tokola Heikki H Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, P.O. BOX 5000, FI-90014 Oulu, Finland; Department of Pathology, Institute of Diagnostics, University of Oulu, P.O. BOX 5000, FI-90014 Oulu, and Department of Pathology, Oulu University Hospital, P.O. BOX 50, FI-90029 OYS, Oulu, - - 2014
Haemodynamic overload exposes the heart to variety of neural, humoral and mechanical stresses. Even without the neurohumoral control of the entire organism cardiac myocytes have the ability to sense mechanical stretch and convert it into adaptive intracellular signals. This process is controlled by several growth factors. Here we show that ...
Dalal Chiraj K CK Howard Hughes Medical Institute, Division of Biology and Bioengineering, California Institute of Technology, Pasadena, CA 91125, - - 2014
The activation of transcription factors in response to environmental conditions is fundamental to cellular regulation. Recent work has revealed that some transcription factors are activated in stochastic pulses of nuclear localization, rather than at a constant level, even in a constant environment [1-12]. In such cases, signals control the mean ...
Hu Wenqian W Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. Electronic address: - - 2014
While we have considerable understanding of the transcriptional networks controlling mammalian cell differentiation, our knowledge of posttranscriptional regulatory events is very limited. Using differentiation of primary erythroid cells as a model, we show that the sequence-specific mRNA-binding protein Cpeb4 is strongly induced by the erythroid-important transcription factors Gata1 and Tal1 and ...
Kim Na Na NN Division of Marine Environment & BioScience, Korea Maritime and Ocean University, Busan 606-791, Republic of - - 2014
This study aimed to test the effects of kisspeptin (Kiss) on somatic growth in the cinnamon clownfish Amphiprion melanopus. We investigated the effects of Kiss treatment on the growth by measuring the mRNA expressions of the growth hormone (GH), insulin-like growth hormone factor (IGF-I), somatolactin (SL), and melatonin receptor (MT). ...
Yahiatène Idir I Division of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616, - - 2014
Activating transcription factor 3 (ATF3) is a member of the mammalian activation transcription factor/cAMP, physiologically important in the regulation of pro- and anti-inflammatory target genes. We compared the induction of ATF3 protein as measured by Western blot analysis with single-molecule localization microscopy dSTORM to quantify the dynamics of accumulation of ...
Pronk Tessa E TE Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O.Box 1, NL- 3720BA Bilthoven, The Netherlands; Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands. Electronic address: - - 2014
For cells, reacting aptly to changes in their environment is of critical importance. The protein Heme oxygenase-1 (HMOX1) plays a critical role as a guard of cellular homeostasis and is considered as a reliable indicator of cellular oxidative stress. A better insight in the regulation of HMOX1 would assist in ...
Soggia Andrea A U1016 Inserm/Institut Cochin, Groupe Hospitalier Cochin Port-Royal, Bâtiment Cassini, 123 Boulevard du Port-Royal, 75014, Paris, - - 2014
Different studies have linked hypoxia to embryonic development. Specifically, when embryonic pancreases are cultured ex vivo under hypoxic conditions (3% O2), beta cell development is impaired. Different cellular signalling pathways are involved in adaptation to hypoxia, including the ubiquitous hypoxia-inducible-factor 1-α (HIF1-α) pathway. We aimed to analyse the effects of ...
Buganim Yosef Y Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Electronic address: - - 2014
Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit high variation in terms of quality, as measured in mice by chimera contribution and tetraploid complementation. Reliably high-quality iPSCs will be needed for future ...
Baejen Carlo C Max-Planck-Institute for Biophysical Chemistry, Am Faßberg 11, 37077 Göttingen, - - 2014
Biogenesis of eukaryotic messenger ribonucleoprotein complexes (mRNPs) involves the synthesis, splicing, and 3' processing of pre-mRNA, and the assembly of mature mRNPs for nuclear export. We mapped 23 mRNP biogenesis factors onto the yeast transcriptome, providing 10(4)-10(6) high-confidence RNA interaction sites per factor. The data reveal how mRNP biogenesis factors ...
Benveniste Dan D School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, United - - 2014
Gene expression in higher organisms is thought to be regulated by a complex network of transcription factor binding and chromatin modifications, yet the relative importance of these two factors remains a matter of debate. Here, we show that a computational approach allows surprisingly accurate prediction of histone modifications solely from ...
Akasaki Yukio Y Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, - - 2014
Objectives. A major signaling pathway that regulates cellular aging is the Insulin/IGF-1/Pl3k/Akt/forkhead-box class O (FOXO) transcription factor axis. Previously, we observed that FOXO factors are dysregulated in aged and OA cartilage. The objective of this study was to investigate the impact of downregulated FOXOs on chondrocytes. Methods. Small interference RNAs ...
Lazare Seka S SS Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: - - 2014
miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into mature blood cells. Regulation bv miRNAs is markedly intertwined with transcription factors. In this review, we highlight miRNAs shown to be important for HSC maintenance and lineage differentiation with ...
Azad Abul Kalam AK Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, - - 2014
Coiled-coil domain containing 3 (CCDC3) is a newly identified secretory protein that is expressed in vascular endothelial cells (ECs) and adipose tissues. Here, we investigate the role of CCDC3 in tumor necrosis factor (TNF)-α-induced inflammatory response in ECs. Our results show that stable overexpression of CCDC3 decreases, while stable knockdown ...
Soni Shefali S Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY - - 2014
The binding of chromatin-associated proteins and incorporation of histone variants correlates with alterations in gene expression. These changes have been particularly well analyzed at the mammalian β-globin locus, where transcription factors such as erythroid Krüppel-like factor (EKLF), which is also known as Krüppel-like factor 1 (KLF1), play a coordinating role ...
Ramackers Wolf W Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany; Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School, Hannover, - - 2014
Patients with liver failure could potentially be bridged with porcine xenogeneic liver cell transplantation. We examined species-specific differences between primary human and porcine hepatocytes in the regulation of coagulation protein expression and function. Isolated primary human and porcine hepatocytes were stimulated with either porcine or human interleukin (IL)-6 (10 ng/ml), IL-1β ...
Muhammad Khalid K Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, - - 2014
In peripheral lymphocytes, the transcription factors (TFs) NF-κB, NFAT and AP-1 are the prime targets of signals that emerge from immune receptors. Upon activation, these TFs induce gene networks that orchestrate the growth, expansion and effector function of peripheral lymphocytes. NFAT and NF-κB factors share several properties, such as a ...
Klenke Stefanie S Institut für Pharmakogenetik, Universität Duisburg-Essen and Universitätsklinikum Essen, Hufelandstr. 55, D-45122 Essen, Germany; Klinik für Anästhesiologie & Intensivmedizin, Universität Duisburg-Essen and Universitätsklinikum Essen, Hufelandstr. 55, D-45122 Essen, Germany. Electronic address: - - 2014
The Gαq/-Gα11- PLCβ1 pathway is important for intracellular signalling and associated with pathological conditions, such as cardiac hypertrophy. The GNAQ and GNA11 promoter (encoding for Gαq and Gα11) have already been characterized and are both regulated by the transcription factor early growth response 1 (Egr-1). In contrast, the PLCB1 promoter ...
Hatade T T Department of Physical Therapy, Faculty of Health Sciences, Kobe University School of Medicine, 7-10-2 Tomogaoka, Sumaku, Kobe, 654-0142, - - 2014
Heat stress could promote skeletal muscle regeneration. But, in the regeneration process, effects of heat stress on myogenic cells and the regulating factors is unknown. Therefore, Influences of heat stress soon after injury on distribution of the myogenic cells and chronological changes in expression of MyoD and myogenin were examined. ...
Wang Weishan W Department of General Surgery, Shandong University Medical School, Jinan, China; Department of General Surgery, Yishui Central Hospital, Linyi, - - 2014
Overexpressions of EGFR and HER2 are thought to be prognostic factors of cholangiocarcinoma (CCA). The SOX4 transcription factor is involved in the development and cell fate decision. Although up-regulation of SOX4 has been described in multiple human malignancies, the prognostic value of SOX4 and its relationship to EGFR/HER2 in CCA ...
D'Asti Esterina E Montreal Children's Hospital, Cancer and Angiogenesis Laboratory, McGill University, H3Z 2Z3, Montreal, Quebec, - - 2014
The coagulation system becomes activated during progression and therapy of high grade brain tumors. Triggering tissue factor (F3/TF) and thrombin receptors (F2R/PAR-1) may influence the vascular tumor microenvironment and angiogenesis irrespective of clinically apparent thrombosis. These processes are poorly understood in medulloblastoma (MB), in which diverse oncogenic pathways define at ...
Gubelmann Carine C Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, - - 2014
Adipose tissue is a key determinant of whole body metabolism and energy homeostasis. Unraveling the regulatory mechanisms underlying adipogenesis is therefore highly relevant from a biomedical perspective. Our current understanding of fat cell differentiation is centered on the transcriptional cascades driven by the C/EBP protein family and the master regulator ...
Nonaka Mio M Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Centre for Cognitive and Neural Systems, University of Edinburgh, 1 George Square EH8 9JZ, United - - 2014
In the field of molecular and cellular neuroscience, it is not a trivial task to see the forest for the trees, where numerous, and seemingly independent, molecules often work in concert to control critical steps of synaptic plasticity and signalling. Here, we will first summarize our current knowledge on essential ...
Li Xiao-Yun XY MOE Key Laboratory of Aquatic Product Safety/State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, 135 Xingang Road West, Guangzhou 510275, P. R. - - 2014
Members of activating transcription factor/cyclic adenosine 3', 5'-monophosphate response element binding protein (ATF/CREB) family are induced by various stress signals and function as effector molecules. Consequently, cellular changes occur in response to discrete sets of instructions. In this work, we found an ATF transcription factor in Litopenaeus vannamei designated as ...
Obermayer Benedikt B Max Delbrück Center (MDC) for Molecular Medicine, Robert Rössle Str. 10, 13125 Berlin-Buch, - - 2014
When ribosomes encounter upstream open reading frames (uORFs) during scanning of the 5' untranslated region (5' UTR), translation of the downstream ORF requires re-initiation. In a recent paper in Nature, Schleich et al. describe metazoan factors which specifically promote re-initiation.
Fatscher Tobias T Institute for Genetics, University of Cologne, 50674 Cologne, - - 2014
Nonsense-mediated mRNA decay (NMD) eliminates different classes of mRNA substrates including transcripts with long 3' UTRs. Current models of NMD suggest that the long physical distance between the poly(A) tail and the termination codon reduces the interaction between cytoplasmic poly(A)-binding protein (PABPC1) and the eukaryotic release factor 3a (eRF3a) during ...
Kim Jong Hyun - - 2014
Adipogenesis is known to be controlled by the concerted actions of transcription factors and co-regulators. However, little is known about the regulation mechanism of transcription factors that control adipogenesis. In addition, the adipogenic roles of translational factors remain unclear. Here, we show that aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1), an ...
Yuan Yike Y Sichuan University, - - 2014
Vascular endothelial growth factor A (Vegfa) is a critical proangiogenic factor that is activated by hypoxia at both the transcriptional and post-transcriptional levels. In hypoxia conditions, stabilized Hypoxia-inducible factor 1α (Hif1α) is the key regulator for transcriptional activation of Vegfa. However, the post-transcriptional control of Vegfa expression remains poorly understood. ...
Tsang Jason Ch JC Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, - - 2014
Recent researches have identified multiple transcription factors as permissible reprogramming factors to pluripotency and lineage switching. The current standard strategy by ectopic factor overexpression however has intrinsic limitations in studying the reprogramming mechanism. There is a growing interest in engineering novel chimeric reprogramming factors and applying designer transcription factors technology ...
Kanamori Yohei Y Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, - - 2014
Expression of hepcidin, a central regulator of systemic iron metabolism, is transcriptionally regulated by the bone morphogenetic protein (BMP) pathway. However, the factors other than the BMP pathway also participate in the regulation of hepcidin expression. In the present study, we show that serum treatment increased hepcidin expression and transcription ...
Lu Ssu-Yi SY Department of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, CA, USA. Electronic address: - - 2014
Transcription factors Mitf and NFATc1 share many downstream targets that are critical for osteoclastogenesis. Since RANKL signals induce/activate both NFATc1 and Mitf isoform-E (Mitf-E), a tissue-restricted Mitf isoform in osteoclasts, it is plausible that the two factors work together to promote osteoclastogenesis. Although Mitf was shown to function upstream of ...
Imayoshi Itaru I Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan; The Hakubi Center, Kyoto University, Kyoto 606-8501, Japan; World Premier International Research Initiative-Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8501, Japan; Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology (PRESTO), 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan. Electronic address: - - 2014
The mammalian brain consists of a complex ensemble of neurons and glia. Their production during development and remodeling is tightly controlled by various regulatory mechanisms in neural progenitor cells (NPCs). Among such regulations, basic helix-loop-helix (bHLH) factors have key functions in the self-renewal, multipotency, and fate determination of NPCs. Here, ...
Bai Long L College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, PR - - 2014
Transforming growth factor-β and related growth factors are essential regulators for the development of follicles. Bone morphogenic protein (BMP) and activin membrane-bound inhibitor (BAMBI) was reported as a key factor participating in the transforming growth factor-β signal pathway. To investigate the role of BAMBI in porcine granulosa cells, the full length ...
Chae Yun-Cheol YC Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul 156-756, South - - 2014
Post-translational modification of forkhead family transcription factor, FoxO1, is an important regulatory mode for its diverse activities. FoxO1 is acetylated by HAT coactivators and its transcriptional activity is decreased via reduced DNA binding affinity. Here, we report that SET/TAF-Iβ inhibited p300-mediated FoxO1 acetylation in an INHAT domain-dependent manner. SET/TAF-Iβ interacted ...
Yang Sheng S Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, - - 2014
microRNAs (miRNAs) are a class of small non-coding RNAs that deregulate and/or decrease the expression of target messenger RNAs (mRNAs), which specifically contribute to complex diseases. In our study, we reanalyzed an integrated data to promote classification performance by rebuilding miRNA-mRNA modules, in which a group of deregulated miRNAs cooperatively ...
Kim Shinuk S College of Liberal Arts, Sangmyung University, 31 Sangmyungdae-gil, Cheonan, Chungnam 330-729, Republic of Korea; Department of Statistics, Seoul National University, 1 Gwankak-ro, Seoul 151-747, Republic of Korea; Department of Mathematics and Statistics, Boston University, 111 Cummington Mall, Boston, MA 02215, USA. Electronic address: - - 2014
Although numerous studies related to cancer survival have been published, increasing the prediction accuracy of survival classes still remains a challenge. Integration of different data sets, such as microRNA (miRNA) and mRNA, might increase the accuracy of survival class prediction. Therefore, we suggested a machine learning (ML) approach to integrate ...
Vanacker Julie J Pharmaceutics and Drug Delivery Unit, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium. Electronic address: - - 2014
Stem cells from the apical papilla (SCAP) are a population of mesenchymal stem cells likely involved in regenerative endodontic procedures and have potential use as therapeutic agents in other tissues. In these situations, SCAP are exposed to hypoxic conditions either within a root canal devoid of an adequate blood supply ...
- - 2014
[This corrects the article on p. 1380 in vol. 6, PMID: 24255666.].
Araya Magdalena M Institute of Nutrition and Food Technology (INTA), University of Chile, Av. El Líbano, 5524, Macul, Santiago, Chile, - - 2014
The chaperone to Zn-Cu superoxide dismutase (CCS) has been postulated as a candidate copper indicator, changing in a consistent manner in induced and recovered copper deficiency, in experimental cell and animal models. In real life people have various conditions that may modify molecules acting as acute phase proteins, such as ...
Yang Jing J Department of Pathology, School of Stomatology, China Medical University, Shenyang City, Liaoning, People's Republic of China; Department of Pathology, Liaoning Medical University, Jingzhou City, Liaoning, People's Republic of - - 2014
Discoidin domain receptors 1 and 2 (DDR1 and DDR2) are members of the receptor tyrosine kinases, which regulate fundamental cellular processes concerning proliferation, differentiation, adhesion, motility, and apoptosis. The dysregulation of these receptors is linked to a number of human diseases, including fibrotic disorders, atherosclerosis, and cancer. However, there have ...
Dong Lei L Department of Anatomy, Basic Medical and Forensic Medical Institute, Sichuan University, Chengdu, Sichuan 610041, P.R. - - 2014
The SET oncoprotein is involved in cancer progression by modulating multiple cellular processes, including the inhibition of the tumor suppressor, protein phosphatase 2 (PP2A). Based upon these multiple activities, we hypothesized that targeted inhibition of SET is likely to have multiple discrete and measurable effects on cancer cells. In the ...
Srivastava Rajneesh R School of Informatics, Indiana University Purdue University, 719 Indiana Ave Ste 319, Walker Plaza Building, Indianapolis, Indiana, - - 2014
Uromodulin is a kidney-specific glycoprotein whose expression can modulate the homeostasis of the kidney. However the set of sequence-specific transcription factors (TFs) which regulate the Uromodulin gene (UMOD) and their upstream binding locations are not well characterized. Our study aims to build a high resolution map of its transcriptional regulation. ...
Correia S S CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, - - 2014
Recent evidence suggested the involvement of calcium-binding protein regucalcin (RGN) in testicular apoptosis. Herein, we investigated the role of RGN controlling apoptotic pathways in the testis by using a transgenic rat model overexpressing RGN (Tg-RGN). Seminiferous tubules (SeT) from Tg-RGN and their wild-type (Wt) counterparts were cultured ex vivo in ...
Brantley-Hill Stacia M SM a Department of Psychology , Middle Tennessee State University , Murfreesboro , Tennessee , - - 2014
People are sometimes hesitant to communicate affection if it might be misinterpreted by the intended receiver or an audience. We hypothesized that anti-gay/-lesbian attitudes might negatively affect the perceived appropriateness of expressing affection. One hundred and twenty male and female undergraduates with either very high or very low levels of ...
Melis Joost P M JP Center for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The - - 2014
There is a high need to improve the assessment of, especially non-genotoxic, carcinogenic features of chemicals. We therefore explored a toxicogenomics-based approach using genome-wide microRNA and mRNA expression profiles upon short-term exposure in mice. For this, wild-type mice were exposed for seven days to three different classes of chemicals, i.e., ...
Wang Hongjun H Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, - - 2014
Rab27a belongs to the Rab small GTPase superfamily. The protein is membrane-bound and may be involved in protein transport and small GTPase-mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. However, the prognostic and molecular features of gliomas with Rab27a expression are still unclear. We ...
Zhang Lanjing L Department of Pathology and Laboratory Medicine, University of Pennsylvania Pearlman School of Medicine, Philadelphia, PA, USA ; Departments of Pathology, University Medical Center of Princeton at Plainsboro/Rutgers Robert Wood Johnson Medical School, Plainsboro, NJ, USA ; Department of Chemical Biology, Ernest Mario School of Pharmacy, Department of Pathology and Lab Medicine, Robert Wood Johnson Medical School, and Cancer Institute of New Jersey, Rutgers University, Piscataway, NJ, - - 2014
Mesothelin, a mesothelial marker, has been found expressed in and as a potential treatment target of cholangioacarcinoma (CC). It is possible that CC may be derived from the cells sharing mesothelial markers. However, the expression of other mesothelial markers in CC is largely unknown. Thirty CC cases (10 extrahepatic and ...
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