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Oleškevič, Renata
The research deals with the expression of causation in English. The aim of the study was to analyse the ways causation is realised in English on the basis of the evidence drawn from the novel "The Picture of Dorian Gray" by O. Wilde. The main objectives were: - to analyse ...
Wang Ying Y Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. - - 2014
The present study aimed to investigate the effects of alcohol on intestinal epithelial barrier permeability and expression of the tight junction‑associated proteins, zonula occludens‑1 (ZO‑1) and claudin‑1. An alcohol‑treated Caco‑2 intestinal epithelial cell monolayer in vitro model was used to investigate whether alcohol is able to induce intestinal barrier dysfunction and ...
Pinheiro Anderson A Department of Obstetrics and Gynecology, State University of Campinas‑UNICAMP School of Medicine, Campinas, São Paulo 13083‑881, - - 2014
The present study examined the immunoexpression of the estrogen receptor (ER), the progesterone receptor (PR), B‑cell lymphoma 2 (Bcl‑2), cyclooxygenase‑2 (Cox‑2) and Ki67 in endometrial polyps and their association with obesity. In total, 515 premenopausal and postmenopausal females undergoing hysteroscopy with histological diagnosis of benign polyps were included. The immunohistochemical ...
Gregersen Lea H LH Max-Delbrück-Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, 13125 Berlin, - - 2014
RNA helicases are important regulators of gene expression that act by remodeling RNA secondary structures and RNA-protein interactions. Here, we demonstrate that MOV10 has an ATP-dependent 5' to 3' in vitro RNA unwinding activity and determine the RNA-binding sites of MOV10 and its helicase mutants using PAR-CLIP. We find that MOV10 ...
van Lier E E 1 Dpto. de Producción Animal y Pasturas, Facultad de Agronomía, Universidad de la República, Avda. E. Garzón 780, 12900 Montevideo, - - 2014
There is strong evidence that the gonads modulate the hypothalamic-pituitary-adrenal axis. To investigate these sex differences at the adrenal glands of sheep we compared the cortisol response to ACTH (experiment 1) and measured the relative expression of oestrogen receptor alpha (ERS1), androgen receptor (AR), melanocortin 2 receptor (MC2R) and steroid ...
Helmig Simone S Institute and Outpatient Clinic for Occupational and Social Medicine - - 2014
Benzo(a)pyrene (BaP), a primary component of tobacco smoke, is activated by cytochrome P450 1B1 (CYP1B1). Smokers homozygous for the C-allele (*1/*1) at the CYP1B1 Leu432Val polymorphism have shown increased CYP1B1 expression, compared to smokers homozygous for the G-allele *3/*3. Since no difference has been shown in CYP1B1 expression between both ...
González-Mariscal J A JA Department of Genetics, University of Málaga, - - 2014
Mx proteins are main effectors of the antiviral innate immune response mediated by type I interferon (IFN I). Actually, diverse Mx proteins from fish proved highly active against fish viruses, standing out among them the Mx1, Mx2 and Mx3 from gilthead seabream (Sparus aurata), a species exhibiting a natural resistance ...
Ji Nanjing N Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture, Dalian Ocean University, Dalian, 116023, - - 2014
Allograft inflammatory factor-1 (AIF-1) is an interferon (IFN)-γ-inducible Ca(2+)-binding cytokine that associates with the immune defense and inflammatory response. In this study, we reported AIF-1 gene in sea cucumber Apostichopus japonicas (AjAIF-1). The full-length cDNA of AjAIF-1 is 1541 bp with an open reading frame (ORF) of 477 bp encoding ...
Chen Yi-Wen YW National Central University, - - 2014
Type 1 fimbriae are filamentous structures on Escherichia coli. These structures are important adherence factors. Because binding to the host cells is the first step of infection, type 1 fimbria is an important virulence factor of pathogenic E. coli. Expression of type 1 fimbria is regulated by a phase variation ...
Zhao Shuangping S Department of Critical Care Medicine, Hunan Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. - - 2014
The aim of the present study was to explore the regulatory mechanism of heme oxygenase‑1 (HO‑1) expression induced by sevoflurane (Sevo) in lipopolysaccharide (LPS)‑induced acute lung injury (ALI). Sprague‑Dawley rats were divided randomly into six groups: (A) Control, (B) 2.4% Sevo only, (C) LY294002 (PI3K inhibitor) only, (D) LPS + 2.4% Sevo, (E) LY294002 + LPS + 2.4% Sevo ...
Morikawa Toshio T Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, - - 2014
A methanol extract of the flower buds of Chimonanthus praecox (L.) Link (Calycanthaceae) demonstrated inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. From the extract, five dimeric pyrrolidinoindoline alkaloids and four sesquiterpenes were isolated, together with 16 known compounds. Among them, (-)-chimonanthine (1, IC50 = 0.93 μM), (-)-folicanthine (2, 1.4 μM), ...
López-Garrido Javier J Departamento de Genética, Universidad de Sevilla, Facultad de Biología, Apartado 1095, 41080 Sevilla, - - 2014
Long 3' untranslated regions (3'UTRs) are common in eukaryotic mRNAs. In contrast, long 3'UTRs are rare in bacteria, and have not been characterized in detail. We describe a 3'UTR of 310 nucleotides in hilD mRNA, a transcript that encodes a transcriptional activator of Salmonella enterica pathogenicity island 1 (SPI-1). Deletion ...
Tsai Yao-Ting YT Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, - - 2014
Lead ions (Pb(2+) ) are toxic industrial pollutants associated with chronic inflammatory diseases in humans and animals. Previously, we found that Pb(2+) ions induce COX-2 gene expression via the EGF receptor/nuclear factor-κB signal transduction pathway in epidermoid carcinoma cell line A431. In this study, to see whether Pb(2+) ions affect ...
Meshcheriakova Yulia A YA Department of Biological Chemistry, John Innes Centre, Norwich, - - 2014
A transient expression system based on a deleted version of Cowpea mosaic virus (CPMV) RNA-2, termed CPMV-HT, in which the sequence to be expressed is positioned between a modified 5' UTR and the 3' UTR has been successfully used for the plant-based expression of a wide range of proteins, including ...
Urbizu Aintzane A Servicio de Anatomía Patológica, Instituto de Investigación en Ciencias de la Salud Germans Trias i Pujol, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, - - 2014
Since cystatin C (CysC) in involved in some forms of neurodegeneration, we investigated the possible relationship between CysC and multiple system atrophy (MSA), including its parkinsonian (MSAp) and cerebellar (MSAc) phenotypes. Cystatin C gene (CST3) haplotypes were determined by PCR followed by KspI digestion in 50 MSA patients and 108 ...
Deng Fei-Yan FY Laboratory of Proteins and Proteomics, Department of Epidemiology, Soochow University School of Public Health, Suzhou, Jiangsu, 205123, P. R. China; Center for Epidemiology and Genomics, Soochow University School of Public Health, Suzhou, Jiangsu, 205123, P. R. China; Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, - - 2014
Low bone mineral density (BMD) is a risk factor of osteoporosis. Osteoporosis is more prevalent in the females than the males. So far, the pathophysiological mechanisms underlying osteoporosis are unclear. Peripheral blood monocytes (PBM) are precursors of bone-resorbing osteoclasts. This study aims to identify PBM-expressed proteins (genes) influencing hip BMD ...
Yang Weining W Sunnybrook Research Institute, Sunnybrook Health Sciences Centre and Centre for the Study of Bone Metastasis, Odette Cancer Centre, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, - - 2014
Versican is an extracellular chondroitin sulfate proteoglycan which functions as a structural molecule but can also regulate a variety of cellular activities. This study was designed to explore the roles of versican in the process of dermal wound repair. To elevate levels of versican, we ectopically expressed the versican 3'-untranslated ...
Lai Xiao Jian XJ College of Fisheries, Jimei University, Xiamen, 361021, People's Republic of - - 2014
Our previous studies suggested that prostaglandin E2 (PGE2) is a putative sex pheromone in Chinese black sleeper Bostrichthys sinensis, a fish species that inhabits intertidal zones and mates and spawns inside a muddy burrow. We found immunoreactivities of PGE2 receptor subtypes (Ep1-3) expressed in the olfactory sac, but only Ep1 ...
Konsavage Wesley M WM Jr Department of Biochemistry & Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033; - - 2014
Mutations in components of the Wnt/ß-catenin signaling pathway are commonly found in colorectal cancers, and these mutations cause aberrant expression of genes controlled by Wnt responsive DNA elements (WREs). While the c-Myc proto-oncogene (Myc) is required for intestinal phenotypes associated with pathogenic Wnt/ß-catenin signaling in vivo, the WREs that control ...
Gessner Denise K - - 2014
In dairy cows, the periparturient phase is a stressful period, which is commonly associated with strong metabolic adaptations and the development of pathophysiologic conditions and disorders. Some of the symptoms occurring in the liver, such as the development of fatty liver, are similar to those observed under the condition of ...
Cao Shan S Cell Biology Group, Department of Surgery, Baltimore, Maryland 21201 Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201 Baltimore Veterans Affairs Medical Center, Baltimore, Maryland 21201 Laboratory of Genetics, National Institute on Aging-IRP, NIH, Baltimore, Maryland - - 2014
Smad ubiquitin regulatory factor 2 (Smurf2) is an E3 ubiquitin ligase that regulates TGF-β/Smad signaling and is implicated in a wide variety of cellular responses, but the exact mechanisms that control Smurf2 abundance remain largely unknown. Here we identified microRNA-322 (miR-322) and miR-503 as novel factors that regulate Smurf2 expression ...
Kim Jin-Hong JH Cell Dynamics Research Center and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, - - 2014
Osteoarthritis (OA), primarily characterized by cartilage degeneration, is caused by an imbalance between anabolic and catabolic factors. Here, we investigated the role of zinc (Zn(2+)) homeostasis, Zn(2+) transporters, and Zn(2+)-dependent transcription factors in OA pathogenesis. Among Zn(2+) transporters, the Zn(2+) importer ZIP8 was specifically upregulated in OA cartilage of humans ...
Bijlstra Gijsbert G 1Behavioural Science Institute, Radboud University Nijmegen, The - - 2014
We investigated whether stereotype associations between specific emotional expressions and social categories underlie stereotypic emotion recognition biases. Across two studies, we replicated previously documented stereotype biases in emotion recognition using both dynamic (Study 1) and static (Study 2) expression displays. Stereotype consistent expressions were more quickly decoded than stereotype inconsistent ...
Jarque Sergio S Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Molecular and Cellular Biology, Jordi Girona, 18, 08034 Barcelona, Spain; Masaryk University, Faculty of Science, RECETOX, Kamenice 5/753, Brno CZ62500, Czech - - 2014
Hepatic mRNA levels of the dio2 gene (deiodinase 2), implicated in thyroid hormone homeostasis, were analyzed in trout from six remote lakes in the Pyrenees (Spain) and the Tatra Mountains (Slovakia). Highest levels corresponded to fish from the two coldest lakes in Pyrenees, whereas relatively low levels were found in ...
He Xiangjun X Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing 100044, China. Email: - - 2014
Oncofetal protein high-mobility-group AT-hook protein 2 (HMGA2) is reactivated in serous ovarian cancer (SOC) and its overexpression correlates with poor prognosis. To explore the mechanism, we investigated whether HMGA2 could avoid microRNA regulation due to gene truncation or 3' UTR shortening by alternative polyadenylation. Real-time reverse transcription polymerase chain reaction ...
Svala Emilia E Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, Pharmacology and Toxicology, Swedish University of Agricultural Sciences, 750 07 Uppsala, - - 2014
Objective-To determine the effects of interleukin (IL)-6 and IL-1β stimulation on expression of growth differentiation factor (GDF)-5 and Wnt signaling pathway genes in equine chondrocytes. Sample-Macroscopically normal articular cartilage samples from 6 horses and osteochondral fragments (OCFs) from 3 horses. Procedures-Chondrocyte pellets were prepared and cultured without stimulation or following ...
Ran Guang Ming - - 2014
Human beings do not passively perceive the facial expressions of other people, but predict observed facial expressions by employing past experiences. The aim of the current study was to investigate whether and how anticipation affected the perception of facial expressions. A 3-way repeated-measures ANOVA on anticipation, orientation, and facial expression ...
Kasimanickam R R Department of Veterinary Clinical Sciences, Washington State University, Pullman, Washington, USA. Electronic address: - - 2014
Mucin (MUC) 1 is an inducible innate immune effector, an important component of defense against bacterial invasion, and is linked with infertility in humans. The objectives were to evaluate messenger RNA (mRNA) expression of MUC1 and cytokine genes in the endometrium of cows with various postpartum uterine inflammatory conditions or ...
Sagar Vidya V Department of biological Sciences, Florida International University, Miami, Florida International University, Miami, Florids-33199. Electronic address: - - 2014
Mammalian orthoreovirus mRNAs possess short 5'UTR, lack 3' poly(A) tails, and may lack 5' cap structures at late times post-infection. As such, the mechanisms by which these viral mRNAs recruit ribosomes remain completely unknown. Towards addressing this question, we used bicistronic MRV M3 mRNA to analyze the role of 5' ...
Jiang L C LC Shandong Provincial Hospital Affiliated to Shandong University, Department of Oral and Maxillofacial Surgery, Jinan, - - 2014
Beclin 1 plays a critical role in autophagy and functions as a haploinsufficient tumor suppressor. The expression and prognostic significance of beclin 1 in head and neck adenoid cystic carcinoma (ACC) are largely unexplored. Therefore, we investigated the expression of beclin 1, Bcl-2, and p53 in head and neck ACC ...
Nan Xuemei X Chinese Academy of Agricultural - - 2014
This study was conducted to determine the optimum ratio of Lysine and Methionine (Lys:Met) to enhance milk protein concentration in vitro, focusing on the regulation of genes related to the JAK2-STAT5 and the mTOR signaling pathways. A preliminary dose response study revealed that casein concentration peaked (2.5-2.7 ppm) at a ...
Xie Yin Y State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060, Guangdong Province, - - 2014
Checkpoint kinase 1 (CHEK1) is an evolutionarily conserved Ser/Thr kinase, which mediates cell-cycle arrest after DNA damage, and we previously reported that CHEK1 was overexpressed and associated with poor prognosis in hepatocellular carcinoma (HCC), indicating it was oncogenic gene. In this study, we aimed to elucidate the mechanism of CHEK1 ...
Cao Qi Q 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [3] Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, Texas 77030, USA [4] Cancer Center, Houston Methodist Research Institute, Houston, Texas 77030, - - 2014
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of ...
Jiang Q D QD College of Veterinary Medicine, Northwest A & F University, Yangling, Shaanxi, - - 2014
This study aimed to compare the effects of lipopolysaccharide (LPS) on stearoyl-coenzyme A desaturase (SCD) gene expression in mouse primary hepatic cells. To obtain sufficient total RNA, primary hepatic cells were plated on 6-cm diameter type collagen 1-coated dishes (1 x 10(6) cells per dish). The test was divided into ...
Bullard Daniel C DC Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, - - 2014
Intercellular adhesion molecule‐1 (ICAM‐1) plays an important role in leukocyte trafficking, induction of cellular immune responses, and immunological synapse formation. As a member of the immunoglobulin superfamily of adhesion proteins, ICAM‐1 is composed of repeating Ig‐like domains, a transmembrane domain, and short cytoplasmic tail that participates in intracellular signaling events. ...
Cho Hyun Kook HK Biotechnology Research Division, National Fisheries Research and Development Institute, 216 Gijanghaean-ro, Gijang-eup, Gijang-gun, Busan, 619-705, Republic of - - 2014
Peroxiredoxins (Prxs), also known as natural killer cell enhancing factors in fish, role as antioxidant proteins and participate in a variety of biological processes, including H2O2-mediated cell signaling, molecular chaperoning, and mitochondrial function. In this study, we isolated and characterized a Prx 1 cDNA from the Korean rose bitterling Rhodeus ...
Renu Indu Kumari IK Department of Biotechnology, Birla Institute of Technology, Mesra, Ranchi, 835215, - - 2014
Eugenol-O-methyltransferase (EOMT) catalyzes the conversion of eugenol to methyleugenol in one of the final steps of phenylpropanoid pathway. There are no comprehensive reports on comparative EOMT gene expression and developmental stage specific accumulation of phenylpropenes in Ocimum tenuiflorum. Seven chemotypes, rich in eugenol and methyleugenol, were selected by assessment of ...
Carpentier C C Inserm UMR837-1 and Univ. Lille Nord de France, Jean-Pierre Aubert Research Center, Alzheimer & Tauopathies, F-59045 Lille, France; Regional University Hospital of Lille, - - 2014
The splicing of the microtubule-associated protein Tau is regulated during development and is found to be deregulated in a growing number of pathological conditions such as myotonic dystrophy type I (DM1), in which a reduced number of isoforms is expressed in the adult brain. DM1 is caused by a dynamic ...
Lee Kyung-Ha KH Department of Life Sciences, Pohang University of Science and Technology, San 31 Hyoja-dong, Pohang, Gyeongbuk 790-784, Republic of Korea, School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, San 31 Hyoja-dong, Pohang, Gyeongbuk 790-784, Republic of Korea and Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, San 31 Hyoja-dong, Pohang, Gyeongbuk 790-784, Republic of - - 2014
In the present study, we investigated the 3' untranslated region (UTR) of the mouse core clock gene cryptochrome 1 (Cry1) at the post-transcriptional level, particularly its translational regulation. Interestingly, the 3'UTR of Cry1 mRNA decreased its mRNA levels but increased protein amounts. The 3'UTR is widely known to function as ...
Polettini J J Division of Maternal-Fetal Medicine and Perinatal Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA; Department of Pathology, Botucatu Medical School, UNESP - Univ. Estadual Paulista, Botucatu, Sao Paulo, - - 2014
Nicotinamide adenine dinucleotide phosphate oxidases (NOX 1-5) are enzymes that generate cellular reactive oxygen species (ROS) besides mitochondria and might be important ROS sources associated with pregnancy complications, particularly preterm premature rupture of membranes (pPROM), that has been related to ROS. To characterize NOX enzymes expression in human fetal membranes. ...
Caussy Cyrielle C Fédération d'Endocrinologie, Maladies Métaboliques, Diabète, et Nutrition, Hôpital Louis Pradel, Hospices Civils de Lyon, 69677 Bron Cedex, France; Laboratoire Carmen, Institut National de la Santé et de la Recherche Médicale U1060, Institut National de la Recherche Agronomique U1235, Institut National des Sciences Appliquées de Lyon, Université Claude Bernard Lyon 1, 69621 Villeurbanne Cedex, - - 2014
APOA5 c.(∗)158C>T (rs2266788), located in the 3' UTR, belongs to APOA5 haplotype 2 (APOA5(∗)2), which is strongly associated with plasma triglyceride levels and modulates the occurrence of both moderate and severe hypertriglyceridemia. Individuals with APOA5(∗)2 display reduced APOA5 expression at the posttranscriptional level. However, the functionality of this haplotype remains ...
Redmond Eileen M EM Department of Surgery, University of Rochester Medical Center, Rochester, New York, United States of - - 2014
To determine the efficacy of perivascular delivery of Notch 1 siRNA in preventing injury-induced arterial remodeling. Carotid artery ligation was performed to induce arterial remodeling. After 14 days, morphometric analysis confirmed increased vSMC growth and subsequent media thickening and neointimal formation. Laser capture microdissection, quantitative qRT-PCR and immunoblot analysis of ...
Studtmann Katrin K Institut für Humangenetik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, - - 2014
Local protein synthesis in dendrites enables neurons to selectively change the protein complement of individual postsynaptic sites. Though it is generally assumed that this mechanism requires tight translational control of dendritically transported mRNAs, it is unclear how translation of dendritic mRNAs is regulated. We have analyzed here translational control elements ...
Gao Xiaoqing X Centre for Vision Research, York University, Toronto, ON - - 2014
To examine individual differences in adults' sensitivity to facial expressions, we used a novel method that has proved revealing in studies of developmental change. Using static faces morphed to show different intensities of facial expressions, we calculated two measures: (1) the threshold to detect that a low intensity facial expression ...
Sement François M FM Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg, Strasbourg Cedex, - - 2014
Uridine addition at the 3' end of RNAs (i.e., uridylation) emerges as a critical posttranscriptional modification promoting RNA degradation. Uridylation has been notably linked to the degradation of small RNAs, correlated with the 5' shortening of RISC-cleaved transcripts and the degradation of mRNAs. We describe here a method based on ...
Cornett Ashley L AL Department of Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, New Jersey Medical School, Rutgers, The State University of New Jersey, 185 South Orange Avenue, Newark, NJ, 07103, - - 2014
3' end formation of eukaryotic messenger RNAs (mRNAs) is an essential process that influences mRNA stability, turnover, and translation. Polyadenylation is the process by which mRNAs are cleaved at specific sites in response to specific RNA sequence elements and binding of trans-acting protein factors; these cleaved mRNAs subsequently acquire non-templated ...
Thonig Anne - - 2014
Haemocyanin is the respiratory protein of most of the Mollusca. In cephalopods and gastropods at least two distinct isoforms are differentially expressed. However, their physiological purpose is unknown. For the common cuttlefish Sepia officinalis, three isoforms are known so far, whereas for only two of them the complete mRNA sequences ...
Brumann M M Department of Trauma Surgery, Ludwig Maximilians University Hospital Munich, Nußbaumstraße 20, 80336 Munich, - - 2014
Background. Fulminant changes in cytokine receptor signalling might provoke severe pathological alterations after multiple trauma. The aim of this study was to evaluate the posttraumatic imbalance of the innate immune system with a special focus on the STAT/SOCS family. Methods. 20 polytraumatized patients were included. Blood samples were drawn 0 h-72 h ...
Haas Jigal J Human Reproduction Lab and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, - - 2014
To investigate the mRNA expression of genes related to steroidogenesis and OHSS in granulosa cells (GCs) of patients triggered with GnRH agonist compared to patients triggered with hCG. Mural GCs were obtained at the time of oocyte retrieval and gene expression was analyzed using quantitative real time RT-PCR. Single center, ...
Juan Wen Chun WC Cancer and Stem Cell Biology Signature Research Programme, Duke-NUS Graduate Medical School, Singapore, - - 2014
Aberrant changes in the expression of the pro-apoptotic protein, BCL-2-like 11 (BIM), can result in either impaired or excessive apoptosis, which can contribute to tumorigenesis and degenerative disorders, respectively. Altering BIM pre-mRNA splicing is an attractive approach to modulate apoptosis because BIM activity is partly determined by the alternative splicing ...
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