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Oleškevič, Renata
The research deals with the expression of causation in English. The aim of the study was to analyse the ways causation is realised in English on the basis of the evidence drawn from the novel "The Picture of Dorian Gray" by O. Wilde. The main objectives were: - to analyse ...
Dineen Aidan - - 2014
BackgroundRegulation of organ and body size is a fundamental biological phenomenon, requiring tight coordination between multiple tissues to ensure accurate proportional growth. In C. elegans, a TGF-ß pathway is the major regulator of body size and also plays a role in the development of the male tail, and is thus ...
Zhang Yingying Y College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, - - 2014
Bisphenol A (BPA), an estrogenic monomer, has attracted many researchers to study its adverse effects in animal reproduction, especially in fish. To explore the effects of low dose BPA on adult female rare minnow Gobiocypris rarus, we exposed the fish to BPA at nominal concentrations of 5, 15, and 50μgL(-1) ...
Ma Wanshan - - 2014
Twist 1 is highly expressed in adipose tissue and has been associated with obesity and related disorders. However, the molecular function of Twist 1 in adipose tissue is unclear. Twist 1 has been implicated in cell lineage determination and differentiation. Therefore, we investigated both the role of Twist 1 in ...
Vaghi Valentina V University of Trieste, - - 2014
The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) is a key regulator of neuronal development and plasticity. BDNF is a major pharmaceutical target in neurodevelopmental and psychiatric disorders. However, pharmacological modulation of this neurotrophin is challenging because BDNF is generated by multiple, alternatively spliced transcripts with different 5' and 3'UTRs. Each BDNF ...
Kaneko Yu Y Faculty of Agriculture and Life Sciences, Hirosaki University, Hirosaki 036-8561, Japan; Graduate School of Agricultural Sciences, Iwate University, Morioka 020-8550, - - 2014
Molting and metamorphosis are essential events for arthropod development, and juvenile hormone (JH) and its precursors play critical roles for these events. We examined the regulation of JH biosynthesis by the corpora allata (CA) in Bombyx mori, and found that intact brain-corpora cardiaca (CC)-CA complexes produced a smaller amount of ...
Hamatani Hiroko H Gunma University Graduate School of - - 2014
Sestrin 2, initially identified as a p53 target protein, accumulates in cells exposed to stress and inhibits mammalian target of rapamycin (mTOR) signaling. In normal rat kidneys, sestrin 2 was selectively expressed in the PECs, identified by the marker PGP9.5. In adriamycin nephropathy, sestrin 2 expression decreased in PECs on ...
Boele Joost J http://orcid.org/0000-0002-7183-9650 RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan;Department of Systems Bioinformatics, Amsterdam Institute for Molecules, Medicines and Systems, VU University Amsterdam, 1081 HV, Amsterdam, The - - 2014
Next-generation sequencing experiments have shown that microRNAs (miRNAs) are expressed in many different isoforms (isomiRs), whose biological relevance is often unclear. We found that mature miR-21, the most widely researched miRNA because of its importance in human disease, is produced in two prevalent isomiR forms that differ by 1 nt ...
Seo Myoung Suk MS The Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3010, Australia; Department of Psychiatry, The University of Melbourne Parkville, Victoria 3010, Australia. Electronic address: - - 2014
We previously identified a group of subjects with schizophrenia who, on average, have a 75% decrease in cholinergic receptor, muscarinic 1 (CHRM1) in Brodmann's area (BA) 9. To extend this finding, we determined i) if the decrease in CHRM1 was present in another functionally related CNS region (BA6), ii) whether ...
Jakimovski Dejan D Department of Neurosurgery - - 2014
Object Endothelial tight junction (TJ) expression is mostly absent in cerebral cavernous malformations (CMs), which causes increased perilesional erythrocyte and fluid oozing. However, in a subset of CM lesions, foci of preserved TJ staining are observed along endothelial cell contacts. The clinical relevance of this finding is unclear. This study ...
Yang T T Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education,Institute of Animal Nutrition,Sichuan Agricultural University,Chengdu,Sichuan 611130,P. R. - - 2014
MicroRNAs are endogenous ~22nt RNAs that negatively regulate gene expression at the posttranscriptional level via binding to the 3'-untranslated region (3'UTR) of target mRNAs. The microRNA miR-27a was reported to depress the expression of myostatin, a critical inhibitor of skeletal myogenesis, by binding to its 3'UTR in mouse. In this ...
Belew Ashton Trey AT 1] Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA - - 2014
Programmed -1 ribosomal frameshift (-1 PRF) signals redirect translating ribosomes to slip back one base on messenger RNAs. Although well characterized in viruses, how these elements may regulate cellular gene expression is not understood. Here we describe a -1 PRF signal in the human mRNA encoding CCR5, the HIV-1 co-receptor. ...
Asseline Ulysse U Centre de Biophysique Moléculaire, CNRS UPR4301, Inserm and Université d'Orléans, 45071, Orléans cedex 2, - - 2014
Antisense oligonucleotides are promising medicines to treat various diseases but their efficiency still requires high doses. Their delivery in the cytosol and nucleus to reach their mRNA targets would increase their efficiency while reducing the dose. For this purpose, we have conjugated the histidine-rich peptide H5WYG (GLFHAIAHFIHGGWHGLIHGWYG) at the 5'-end ...
Ogawa Atsushi A Proteo-Science Center, Ehime University, 3 Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan. Electronic address: - - 2014
High-quality wheat germ extract (hqWGE) is very useful for the high-yield production of various types of protein. The most important key to high productivity is the design of mRNA templates. Although the design has been refined for straightforward and efficient translation in hqWGE, there is still room for improvement in ...
Islam Zinia Z Tokyo Institute of - - 2014
The kidney of marine teleosts is the major site of Mg(2+) excretion and produces urine with a high Mg(2+) concentration. However, the transporters involved in Mg(2+) excretion are poorly understood. The cyclin M (Cnnm; also known as ancient conserved domain protein) family comprises membrane proteins homologous to the bacterial Mg(2+) ...
Wang Gaoyang G Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning, People's Republic of - - 2014
The aim of this study was to explore the effects of 1,2-dichloroethane (1,2-DCE) on expression of aquaporins (AQPs) and matrix metalloproteinases (MMPs) in the process of brain edema formation. Two parts were included in this study, establishment of animal model of brain edema, and mechanism of brain edema induced by ...
Simionescu Natalia N Lipidomics Department, Institute of Cellular Biology and Pathology "Nicolae Simionescu", Romanian Academy, 8, B.P. Hasdeu Street, 050568, Bucharest, - - 2014
MicroRNAs (miRNAs) are small non-coding RNA sequences that regulate gene expression post-transcriptionally by translation inhibition or mRNA degradation. The aim of the present study was to analyze serum miRNAs modulated by hyperlipidemia and/or hyperglycemia and to correlate them with biochemical parameters within lipid metabolism. Five selected circulating miRNAs (miR-125a-5p, miR-146a, ...
Biswas Ambarish - - 2014
Gene expression in vertebrate cells may be controlled post-transcriptionally through regulatory elements in mRNAs. These are usually located in the untranslated regions (UTRs) of mRNA sequences, particularly the 3[prime]UTRs. Scan for Motifs (SFM) simplifies the process of identifying a wide range of regulatory elements on alignments of vertebrate 3[prime]UTRs. SFM ...
Liu C C CC Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong. Electronic address: - - 2014
Hypoxia-inducible factor (HIF) is commonly found in vertebrates as an adaptation against hypoxia. In this study, partial sequences of HIF were first reported for subtidal nassariid gastropods, Nassarius siquijorensis and Nassarius conoidalis. The phylogenetic tree of HIF-α among various animal groups was inferred. Adults of both N. siquijorensis and N. conoidalis were ...
Miura Pedro P Department of Developmental Biology, Sloan-Kettering Institute, New York, NY, - - 2014
Alternative cleavage and polyadenylation (APA) can diversify coding and non-coding regions, but has particular impact on increasing 3' UTR diversity. Through the gain or loss of regulatory elements such as RNA binding protein and microRNA sites, APA can influence transcript stability, localization, and translational efficiency. Strikingly, the central nervous systems ...
Zhang Wenwen W Department of Medical Oncology - - 2014
Abstract Considering the role of variants in the 3' untranslated region (3'UTR) of GPR30 gene remains unclear, we analyzed the association between the variants at the GPR30 gene 3'UTR miRNA binding sites and their mRNA expression using the data from the HapMap online database. Nine single nucleotide polymorphisms (SNPs) in ...
Kračmerová Jana J Department of Sport Medicine,Third Faculty of Medicine, Charles University in Prague, Ruská 87,100 00,Prague 10,Czech - - 2014
The consumption of lipids and simple sugars induces an inflammatory response whose exact molecular trigger remains elusive. The aims of the present study were to investigate (1) whether inflammation induced by a single high-energy, high-fat meal (HFM) is associated with endoplasmic reticulum stress (ERS) in peripheral blood mononuclear cells (PBMC) ...
Nelson Nicole L - - 2014
Prior research has identified a facial expression for positive pride, but no expression for negative pride, hubris. In the present study, professional actors created expressions intended to convey hubris. In Study 1 (N = 52), participants were shown dynamic expressions and attributed confidence, positive valence, and positive personality traits to ...
Li Xiaomin X Key Laboratory for Bio-feed and Molecular Nutrition, Southwest University,Chongqing400715,People's Republic of - - 2014
Grape seed extract (GSE), a rich source of polyphenols, is reported to possess antioxidant, anti-inflammatory and immunomodulatory properties. The objective of the present study was to determine whether GSE could attenuate the heat stress-induced responses of jejunum epithelial cells (JEC) in cattle. The JEC of a steer (Simmental ×  Qinchuan) ...
Shen Minqian M Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, PR - - 2014
Aims: To observe the effect of TC14012 (a CXCR4 antagonist and CXCR7 agonist) on alkali burn-induced corneal neovascularization (CNV) in a mouse model. Methods: CNV was induced in vivo by alkali burns on the corneas of BALB/c mice. A total of 54 mice treated with alkali burns were randomly divided ...
Wang Zhi-Wei ZW Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, United - - 2014
The functional significance of noncoding transcripts is currently a major question in biology. We have been studying the function of a set of antisense transcripts called COOLAIR that encompass the whole transcription unit of the Arabidopsis floral repressor FLOWERING LOCUS C (FLC). Alternative polyadenylation of COOLAIR transcripts correlates with different ...
Kim Min Young MY Department of Life Science and Research Institute for Natural Sciences, College of Natural - - 2014
Requiem (REQ/DPF2) was originally identified as an apoptosis-inducing protein in mouse myeloid cells and belongs to the novel Krüppel-type zinc finger d4-protein family of proteins, which includes neuro-d4 (DPF1) and cer-d4 (DPF3). Interestingly, when a portion of the REQ messenger ribonucleic acid (mRNA) 3' untranslated region (3'UTR), referred to as ...
Wu Xiaodan X Department of Herbal Medicine, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, P.R. - - 2014
The aim of this study was to investigate the curative effect of Zeng Ye decoction on primary Sjögren's syndrome (pSS) and further explore its underlying mechanism involving aquaporin (AQP)‑1 and AQP‑5. The pSS model was established based on the immune induction method, and the saliva flow, submandibular gland index, morphological ...
Zuccotti Paola P Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Milan, - - 2014
Cyclin-Dependent Kinase 5 Regulatory subunit 1 (CDK5R1) encodes p35, a specific activator of Cyclin-Dependent Kinase 5 (CDK5). CDK5 and p35 have a fundamental role in neuronal migration and differentiation during CNS development. Both the CDK5R1 3'-UTR's remarkable size and its conservation during evolution strongly indicate an important role in post-transcriptional ...
Jin Lee Eun E College of Pharmacy, Ewha Womans University, Seoul 120-750, - - 2014
Anemarrhena asphodeloides is widely used in traditional Chinese medicine, and is known to possess antidiabetic and anti-inflammatory properties. Because inducible nitric oxide synthase (iNOS) plays an important role in inflammation, we investigated the inhibitory effects of two known phenolic compounds, nyasol (1) and broussonin A (2), from A. asphodeloides, on ...
Bach Frances C FC Faculty of Veterinary Medicine, Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The - - 2014
The endocrine feedback loop between vitamin D3 (1,25(OH)2 D3 ) and parathyroid hormone (PTH) plays a central role in skeletal development. PTH-related protein (PTHrP) shares homology and its receptor (PTHR1) with PTH. The aim of this study was to investigate whether there is a functional paracrine feedback loop between 1,25(OH)2 ...
Wu Wenda W College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, P.R. China; Dept. of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, - - 2014
The foodborne mycotoxin deoxynivalenol (DON) induces a ribotoxic stress response in mononuclear phagocytes that mediate aberrant multi-organ upregulation of TNF-α, interleukins and chemokines in experimental animals. While other DON congeners also exist as food contaminants or pharmacologically-active derivatives, it is not known how these compounds affect expression of these cytokine ...
Hsieh Chen-Lin CL Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA - - 2014
The androgen receptor (AR) is a key factor that regulates the behavior and fate of prostate cancer cells. The AR-regulated network is activated when AR binds enhancer elements and modulates specific enhancer-promoter looping. Kallikrein-related peptidase 3 (KLK3), which codes for prostate-specific antigen (PSA), is a well-known AR-regulated gene and its ...
Leethongdee S S Faculty of Veterinary Sciences, Mahasarakham University, Amphur Muang, Mahasarakham, - - 2014
During the periovulatory period, the cervix relaxes in response to changes in circulating concentrations of reproductive hormones. The present study investigated the role of gonadotrophins in cervical function by examining the expression of follicle-stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHR) and their mRNAs following intracervical treatment with either ...
Muraoka Toko T Department of Medicine II, Tokyo Women's Medical University, Tokyo 162-8666, - - 2014
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is an NADPH-dependent reductase that converts cortisone to cortisol in adipose tissue. We previously reported that GH and IGF-I decrease 11β-HSD1 activity and mRNA levels in adipocytes. Hexose-6-phosphate dehydrogenase (H6PDH) is involved in the production of NADPH, which is a coenzyme for 11β-HSD1. The aim ...
Cartagena Casandra M CM Brain Trauma Neuroprotection and Neurorestoration Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910. Electronic address: - - 2014
Brain edema is a primary factor in the morbidity and mortality of traumatic brain injury (TBI). The various isoforms of aquaporin 4 (AQP4) and aquaporin 9 (AQP9) are important factors influencing edema following TBI. Others have reported that these AQPs are regulated by the transcription factor hypoxia inducible factor (HIF) ...
Wang Ying Y Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. - - 2014
The present study aimed to investigate the effects of alcohol on intestinal epithelial barrier permeability and expression of the tight junction‑associated proteins, zonula occludens‑1 (ZO‑1) and claudin‑1. An alcohol‑treated Caco‑2 intestinal epithelial cell monolayer in vitro model was used to investigate whether alcohol is able to induce intestinal barrier dysfunction and ...
Pinheiro Anderson A Department of Obstetrics and Gynecology, State University of Campinas‑UNICAMP School of Medicine, Campinas, São Paulo 13083‑881, - - 2014
The present study examined the immunoexpression of the estrogen receptor (ER), the progesterone receptor (PR), B‑cell lymphoma 2 (Bcl‑2), cyclooxygenase‑2 (Cox‑2) and Ki67 in endometrial polyps and their association with obesity. In total, 515 premenopausal and postmenopausal females undergoing hysteroscopy with histological diagnosis of benign polyps were included. The immunohistochemical ...
Gregersen Lea H LH Max-Delbrück-Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, 13125 Berlin, - - 2014
RNA helicases are important regulators of gene expression that act by remodeling RNA secondary structures and RNA-protein interactions. Here, we demonstrate that MOV10 has an ATP-dependent 5' to 3' in vitro RNA unwinding activity and determine the RNA-binding sites of MOV10 and its helicase mutants using PAR-CLIP. We find that MOV10 ...
van Lier E E 1 Dpto. de Producción Animal y Pasturas, Facultad de Agronomía, Universidad de la República, Avda. E. Garzón 780, 12900 Montevideo, - - 2014
There is strong evidence that the gonads modulate the hypothalamic-pituitary-adrenal axis. To investigate these sex differences at the adrenal glands of sheep we compared the cortisol response to ACTH (experiment 1) and measured the relative expression of oestrogen receptor alpha (ERS1), androgen receptor (AR), melanocortin 2 receptor (MC2R) and steroid ...
Helmig Simone S Institute and Outpatient Clinic for Occupational and Social Medicine - - 2014
Benzo(a)pyrene (BaP), a primary component of tobacco smoke, is activated by cytochrome P450 1B1 (CYP1B1). Smokers homozygous for the C-allele (*1/*1) at the CYP1B1 Leu432Val polymorphism have shown increased CYP1B1 expression, compared to smokers homozygous for the G-allele *3/*3. Since no difference has been shown in CYP1B1 expression between both ...
González-Mariscal J A JA Department of Genetics, University of Málaga, - - 2014
Mx proteins are main effectors of the antiviral innate immune response mediated by type I interferon (IFN I). Actually, diverse Mx proteins from fish proved highly active against fish viruses, standing out among them the Mx1, Mx2 and Mx3 from gilthead seabream (Sparus aurata), a species exhibiting a natural resistance ...
Ji Nanjing N Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture, Dalian Ocean University, Dalian, 116023, - - 2014
Allograft inflammatory factor-1 (AIF-1) is an interferon (IFN)-γ-inducible Ca(2+)-binding cytokine that associates with the immune defense and inflammatory response. In this study, we reported AIF-1 gene in sea cucumber Apostichopus japonicas (AjAIF-1). The full-length cDNA of AjAIF-1 is 1541 bp with an open reading frame (ORF) of 477 bp encoding ...
Chen Yi-Wen YW National Central University, - - 2014
Type 1 fimbriae are filamentous structures on Escherichia coli. These structures are important adherence factors. Because binding to the host cells is the first step of infection, type 1 fimbria is an important virulence factor of pathogenic E. coli. Expression of type 1 fimbria is regulated by a phase variation ...
Zhao Shuangping S Department of Critical Care Medicine, Hunan Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. - - 2014
The aim of the present study was to explore the regulatory mechanism of heme oxygenase‑1 (HO‑1) expression induced by sevoflurane (Sevo) in lipopolysaccharide (LPS)‑induced acute lung injury (ALI). Sprague‑Dawley rats were divided randomly into six groups: (A) Control, (B) 2.4% Sevo only, (C) LY294002 (PI3K inhibitor) only, (D) LPS + 2.4% Sevo, (E) LY294002 + LPS + 2.4% Sevo ...
Morikawa Toshio T Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, - - 2014
A methanol extract of the flower buds of Chimonanthus praecox (L.) Link (Calycanthaceae) demonstrated inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. From the extract, five dimeric pyrrolidinoindoline alkaloids and four sesquiterpenes were isolated, together with 16 known compounds. Among them, (-)-chimonanthine (1, IC50 = 0.93 μM), (-)-folicanthine (2, 1.4 μM), ...
López-Garrido Javier J Departamento de Genética, Universidad de Sevilla, Facultad de Biología, Apartado 1095, 41080 Sevilla, - - 2014
Long 3' untranslated regions (3'UTRs) are common in eukaryotic mRNAs. In contrast, long 3'UTRs are rare in bacteria, and have not been characterized in detail. We describe a 3'UTR of 310 nucleotides in hilD mRNA, a transcript that encodes a transcriptional activator of Salmonella enterica pathogenicity island 1 (SPI-1). Deletion ...
Tsai Yao-Ting YT Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, - - 2014
Lead ions (Pb(2+) ) are toxic industrial pollutants associated with chronic inflammatory diseases in humans and animals. Previously, we found that Pb(2+) ions induce COX-2 gene expression via the EGF receptor/nuclear factor-κB signal transduction pathway in epidermoid carcinoma cell line A431. In this study, to see whether Pb(2+) ions affect ...
Hubert O O CIRAD, UMR QUALISUD, F-97130 Capesterre-Belle-Eau, Guadeloupe, France; CIRAD, UMR QUALISUD, F-34398 Montpellier, France. Electronic address: - - 2014
Banana finger drop was examined in ripening banana harvested at immature (iMG), early (eMG) and late mature green (lMG) stages, with contrasting ripening rates and ethylene sensitivities. Concomitantly, 11 ethylene signal transduction components (ESTC) and 6 MADS box gene expressions were comparatively studied in median (control zone, CZ) and pedicel ...
Meshcheriakova Yulia A YA Department of Biological Chemistry, John Innes Centre, Norwich, - - 2014
A transient expression system based on a deleted version of Cowpea mosaic virus (CPMV) RNA-2, termed CPMV-HT, in which the sequence to be expressed is positioned between a modified 5' UTR and the 3' UTR has been successfully used for the plant-based expression of a wide range of proteins, including ...
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