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Yang Min M Department of Physiology, School of Basic Medical Science, Ningxia Medical University, Ningxia 750004, P.R. - - 2014
The purpose of the present study was to investigate the effects of high ambient temperature on the neuropeptide Y (NPY) mRNA level in the hypothalamus, the plasma concentration of corticotropin-releasing hormone (CRH), cortisol (Cor), heat-shock protein 70 (HSP70) and epinephrine (EPI), and the intervention of lycium barbarum polysaccharides (LBPs) in ...
Hegedűs Péter P Department of Cardiac Surgery, University of Heidelberg, INF 326, Heidelberg, 69120, Germany, - - 2014
Neointima formation following angioplasty is a serious consequence of endothelial damage in arteries. Inflammatory mediators and lack of endothelial regulatory mechanisms lead to migration and proliferation of smooth-muscle cells and thus to restenosis. This study examines the effect of the novel bis (aspirinato) zinc (II) complex on neointima formation in ...
Gonçalves J O JO Laboratório de Pesquisa em Cirurgia Pediátrica (LIM-30), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, - - 2014
We previously described a selective bile duct ligation model to elucidate the process of hepatic fibrogenesis in children with biliary atresia or intrahepatic biliary stenosis. Using this model, we identified changes in the expression of alpha smooth muscle actin (α-SMA) both in the obstructed parenchyma and in the hepatic parenchyma ...
Feng Jian J Department of Cardiology, Southwest Hospital, Third Military Medical University and Chongqing Institute of Interventional Cardiology, Chongqing, 400038, People's Republic of - - 2014
Percutaneous coronary interventions (PCIs) are an effective treatment for obstructive coronary artery diseases. However, the procedure's success is limited by remodeling and formation of neointima. In the present study, we engineered rat mesenchymal stem cells (MSCs) to express type 2 angiotensin II receptor (AT2R) using a tetracycline-regulated system that can ...
Kargaran Parichehr P From the Department of Anesthesiology, Pharmacology and Intensive Care, University Hospitals of Geneva (PK, J-CC, LV), Department of Fundamental Neuroscience (PK, LV), Geneva Neuroscience Center, University of Geneva Medical School (LV), Division of Cardiology, Foundation for Medical Researches, Department of Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland (SL, FM, FM, J-CC), Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy (FM), Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland - - 2014
Recent experimental data indicate that volatile anaesthetics can induce a neuroinflammatory response in the central nervous system. The questions of to what extent this occurs in the developing brain and whether nonvolatile anaesthetics are also involved remain unanswered. The objective of this study is to investigate the impact of propofol ...
Sato Youichi Y Y Sato, Pharmaceutical Information Science, Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan - - 2014
We previously reported that dipeptidyl peptidase 4 (DPP4)-deficient rats were susceptible to reduced glomerular filtration rate as a result of streptozotocin (STZ)-induced diabetes. Therefore, we proposed that DPP4 might be responsible for the preservation of renal function. In this study, to verify the role of DPP4 in the preservation of ...
Ahmed Muhammed Rauf MR National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, - - 2014
To evaluate the therapeutic efficacy of ADMSCs in combination with chondrocytes in counteracting oxidative stress in chondrocytes in vitro and in rat model of osteoarthritis (OA). Cultured chondrocytes were exposed to oxidative stress with 200 μM H2O2, followed by co-culture with ADMSCs or chondrocytes or combination of both cell types ...
Kovács-Öller Tamás T Department of Experimental Zoology and Neurobiology, University of Pécs, Pécs, Ifjúság street 6, - - 2014
Connexin36 (Cx36) is the major gap junction forming protein in the brain and the retina; thus, alterations in its expression indicate changes in the corresponding circuitry. Many structural changes occur in the early postnatal retina before functional neuronal circuits are finalized, including those that incorporate gap junctions. To reveal the ...
Mohd Mokhtar Helmy H Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603 - - 2014
Estrogen is known to stimulate uterine fluid and Cl(-) secretion via CFTR. This study investigated testosterone effect on these changes in a rat model. Ovariectomised adult female rats received estrogen for five days or estrogen for three days followed by two days peanut oil or testosterone either alone or in ...
Wu Jian J Department of Anesthesiology, Shengjing Hospital, China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, - - 2014
The present study was designed to determine the effects of chronic intermittent hypoxia (CIH) on pain sensitivity and the changes in the expression of delta-opioid receptor (DOR), mu-opioid receptor (MOR), and hypoxia-inducible factor (HIF)-1α and their relationship with pain sensitivity under hypoxia. CIH was employed to model the low oxygen ...
Deng Changqing C Department of Infectious Diseases, First Hospital Affiliated to Suzhou University, Suzhou, 215006, Jiangsu, - - 2014
The role of C-X-C chemokine receptor type 4 (CXCR4) in umbilical mesenchymal stem cells (UMSCs) as therapy for liver disease is ill understood. The aim of the study was to evaluate rat UMSCs (rUMSCs) on CXCR4 expression and homing to injured liver tissue. rUMSCs were isolated from umbilical cords of ...
Zhang Xiaolu X Department of pharmacology, Xi'an Jiaotong University School of Medicine, Xi'an 710061, - - 2014
Atherosclerosis is a chronic inflammatory disease in the vessel. As a representative inflammatory cytokine, C-reactive protein (CRP) participates in atherogenesis. Although hyperaldosteronism is known to evoke inflammatory response in several tissues and cell types, there is no direct evidence to demonstrate the proinflammatory effect of aldosterone on vascular smooth muscle ...
Kusakawa Yuya Y Department of Anatomy & Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka 431-3192, Japan; Department of Rehabilitation, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Nakaku, Hamamatsu, Shizuoka 430-8558, - - 2014
Bone morphogenetic protein-5 (BMP5), a member of the transforming growth factor-β (TGF-β) superfamily, has many effects in several biological events. Although BMP5 expression has been well reported in the early development of the central nervous system (CNS), there's little information about its expression in the adult CNS. Thus, we analyzed ...
Tsai Ching-Hua CH 1Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, - - 2014
ABSTRACT Background: Binding lipopolysaccharide (LPS) with high-affinity, lipopolysaccharide-binding protein (LBP) and CD14 lower the threshold stimulatory concentrations of LPS dramatically and enhance the rate of cytokine production markedly. This study aimed to investigate the kinetic expression of LBP/CD14 and its possible relationship with tumor necrosis factor alpha (TNF-α) to better ...
Zhong Bo B Department of Genetics and Molecular Biology, Departments of Pediatrics and Clinical Laboratory, the Second Affiliated Hospital, and Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University College of Medicine, and Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, Shaanxi, ChinaDepartment of Genetics and Molecular Biology, Departments of Pediatrics and Clinical Laboratory, the Second Affiliated Hospital, and Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University College of Medicine, and Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, Shaanxi, - - 2014
Pdcd4 has been known as a tumor-suppressor gene initially and is up-regulated during apoptosis. Surprisingly, we found that Pdcd4 was differentially expressed in the lung from E3 rats with AIPI, an animal model for asthma, but the precise role of Pdcd4 in AIPI still remained to be defined. In the ...
Qin Li L 1] Division of Stem Cell Regulation and Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China [2] Institute of Pharmacy and Pharmacology, South China University, Hengyang 421001, - - 2014
Aim:To investigate the mechanisms of anti-atherosclerotic action of ezetimibe in rat vascular smooth muscle cells (VSMCs) in vitro.Methods:VSMCs of SD rats were cultured in the presence of Chol:MβCD (10 μg/mL) for 72 h, and intracellular lipid droplets and cholesterol levels were evaluated using Oil Red O staining, HPLC and Enzymatic ...
Görg Boris B Clinic for Gastroenterologogy, Hepatology and Infectious Diseases, Heinrich Heine University, Düsseldorf, - - 2014
Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis and is due to a low-grade cerebral edema associated with oxidative/nitrosative stress. Recent reports suggest that cognitive impairment in cirrhotic patients may not resolve completely after an attack of manifest HE. As astrocyte dysfunction is central to the pathogenesis of ...
Yu De-Shui DS Department of Orthopaedics, The First Affiliated Hospital, Liaoning Medical University, People Street No. 5-2, GuTa District, Jinzhou 121001, Liaoning Province, People's Republic of - - 2014
Previous studies have shown that curcumin (Cur) can produce potent neuroprotective effects against damage due to spinal cord injury (SCI). However, whether Cur can preserve the function of the blood-spinal cord barrier (BSCB) is unclear. The present study was performed to investigate the mechanism underlying BSCB permeability changes, which were ...
Serova L I LI Department of Biochemistry and Molecular Biology, New York Medical College, 10595, Valhalla, New York, - - 2014
Melanocortin receptor four (MC4R) is implicated in regulation of stress-related functions. We previously demonstrated that intranasal infusion of MC4R antagonist HS014, shortly before single prolonged stress (SPS) animal model of post-traumatic stress disorder (PTSD), lessened development of anxiety- and depression-like behavior depending on the dose. Here we evaluated effects of ...
Ahmed Marwa A MA Medical Physiology Department, Faculty of Medicine, Assiut University, Assiut 71526, Egypt. Electronic address: - - 2014
Forty adult female rats were randomly divided into four groups: control, nicotine, nicotine+vitamin C and nicotine+selenium group. Splenic tissues concentrations of thiobarbituric acid reactive substances (TBARS), nitric oxide, superoxide dismutase (SOD) and catalase (CAT) activities were measured. The P53 and Bcl2 proteins were detected by Western blot and their expression ...
van der Linde S S 1Department of Physiology,The University of - - 2014
Uteroplacental insufficiency resulting in intrauterine growth restriction has been associated with the development of cardiovascular disease, coronary heart disease and increased blood pressure, particularly in males. The molecular mechanisms that result in the programming of these phenotypes are not clear. This study investigated the expression of cardiac JAK/STAT signalling genes ...
Wang Yuhong Y Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, - - 2014
Klotho is an antiaging gene and is predominately expressed in kidneys. The endothelin system is critical in the regulation of kidney function. The objective of this study is to assess whether klotho affects the renal endothelin system in spontaneously hypertensive rats (SHRs). Four groups of male SHRs and one group ...
Cui Li-Min LM Department of Biochemistry and Molecular Biology, College of Medicine, Yanbian University, Yanji, Jilin 133002, P.R. China ; Department of Surgery, Affiliated Hospital, Yanbian University, Yanji, Jilin 133002, P.R. - - 2014
The aim of the present study was to investigate the expression of proteins associated with the sustained activation of the signal transducer and activator of transcription (STAT)-3 pathway during diethylnitrosamine (DEN)-induced rat liver carcinogenesis. DEN was intermittently administered to rats to induce liver cancer, and light and electron microscopy were ...
Miyashita Tomoharu T Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Ishikawa 920-8641, - - 2014
Animal models are important for the development of novel therapies for esophageal cancer. Histone deacetylase 1 (HDAC1)/metastasis-associated gene (MTA1) complexes inhibit p53 acetylation and thus, inhibit p53-induced apoptosis. The aim of the present study was to evaluate HDAC1 and MTA1 expression in esophageal carcinogenesis in rats. The rats underwent a ...
Wu Tao T Research Center of Chinese Medicine Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China ; Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. - - 2014
The Chinese medicinal formula, Qinggan (QG) Huoxue (HX) Recipe (R) exerts a range of pharmacological effects, including reversible steatosis, decreased levels of inflammatory cytokines and lipid peroxidation resistance. The aim of the present study was to determine the specific mechanisms of QGHXR hepatoprotection through the lipopolysaccharide-Kupffer cell (LPS-KC) signal conduction ...
Fender Anke C AC Institut für Pharmakologie and Klinische Pharmakologie, Universitätsklinikum der Heinrich-Heine-Universität, Moorenstraße 5, 40225, Düsseldorf, Germany, - - 2014
Activators of protease-activated receptors PAR-1 and PAR-2 such as thrombin and synthetic hexapeptides promote hypertrophy of isolated neonatal cardiomyocytes at pathological concentrations. Since PAR-activating proteases often show dual actions at low vs. high concentrations, the potential hypertrophic effects of low-level PAR activation were examined. In H9c2 cardiomyoblasts, messenger RNA (mRNA) ...
Kosik-Bogacka Danuta I DI Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland. Electronic address: - - 2014
Toll-like receptors (TLRs) play a fundamental role in the rapid activation of innate immune responses to a variety of pathogen-associated molecular patterns (PAMPs). In a previous study we observed an increase in the level of expression of TLR2 and TLR4 mRNA in the jejunum and colon during experimental hymenolepidosis in ...
Xu Ming-Yi MY Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, - - 2014
The role of signal transducer and activator of transcription 3 (Stat3) in liver fibrosis is still controversial. Since hepatic stellate cells (HSCs) and transforming growth factor-β1 (TGF-β1) are central to the fibrogenesis, our goal was to clarify the mechanism of Stat3 crosslinking of TGF-β1 signaling. Stat3, TGF-β1 mRNA and protein ...
Bhan Arunoday A Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas - - 2014
Enhancer of Zeste homolog 2 (EZH2), a histone 3 lysine 27 (H3K27) specific methyltransferase, is a critical player in gene silencing and is overexpressed in breast cancer. Our studies demonstrate that EZH2 is transcriptionally induced by estradiol in cultured breast cancer cells as well as in the mammary glands of ...
Chen Yan Y Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, - - 2014
This study investigated the changes in brain-derived neurotrophic factor (BDNF) expression and the role of furin in BDNF maturation in reactive astrocytes from rats exposed to oxygen-glucose deprivation (OGD). Furin, a proprotein convertase, is upregulated and cleaves certain substrates during hypoxia in cancer cells. In addition, during hypoxia in the ...
Highland Julie J University of Colorado - - 2014
Entrainment of the intrinsic SCN molecular clock to the light:dark cycle depends on photic driven intracellular signal transduction responses of SCN neurons that converges on CREB mediated regulation of gene transcription. Characterization of the CREB co-activator proteins, CREB-regulated transcriptional coactivators (CRTC), has revealed a greater degree of differential activity-dependent modulation ...
Schmiedl Andreas A Institute of Functional and Applied Anatomy, Hannover Medical School, - - 2014
Intact surface active agent (Surfactant) composed of surfactant associated proteins (SPs) and lipids is necessary for respiration and prevents alveoli from collapsing. CD26, a transmembrane glycoprotein exerting dipeptidyl peptidase activity (DPP4), highly expressed in lung parenchyma, is involved in inflammatory processes. A pharmacological inhibition of DPP4 influenced not only the ...
Meng Chenling C College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, - - 2014
Repulsive guidance molecule b (RGMb; a.k.a. Dragon), initially identified in the embryonic dorsal root ganglion, is the first member of the RGM family shown to enhance bone morphogenetic protein (BMP) signaling by acting as a BMP co-receptor. BMP signaling has been demonstrated to play an important role in the reproductive ...
Yamamoto Naoki N Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, - - 2014
The psychotomimetic effects of stimulant drugs including amphetamines and cocaine are known to change during the postnatal development in humans and experimental animals. To obtain an insight into the molecular basis of the onset of stimulant-induced psychosis, we have explored the gene transcripts that differentially respond to methamphetamine (MAP) in ...
Olajide Olumayokun A OA Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, - - 2014
In this study, the effects of punicalagin on neuroinflammation in LPS-activated microglia were investigated. The ability of punicalagin to reduce the production of TNF-α, IL-6 and prostaglandin E2 was measured in culture medium using enzyme immunoassay. TNF-α and IL-6 gene expression in mouse hippocampal slices was measured with PCR. cyclooxygenase-2 ...
Huang Chaoqun - - 2014
Acute respiratory distress syndrome (ARDS) is characterized by pulmonary epithelial injury and extensive inflammation of the pulmonary parenchyma. Systematic analyses of microRNA (miRNA) and mRNA expression profiling in ARDS provide insights into understanding of molecular mechanisms of the pathogenesis of ARDS. The objective of this study was to identify miRNA ...
Sobczyk Karmela K Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University, Düsseldorf, - - 2014
Hepatic encephalopathy (HE) represents a neuropsychiatric syndrome, which evolves as a consequence of a low grade cerebral edema and a concomitant oxidative/nitrosative stress response. Ephrin receptors (EphR) and their ligands (ephrins) regulate astrocytic glutamate uptake and gliotransmitter release thereby governing neurotransmission, but their role in HE and ammonia toxicity is ...
Liu Dong D Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: - - 2014
Calculus Bovis Sativus (CBS) shares similar pharmacological effect with Calculus Bovis like relieving hepatobiliary diseases. This study aims to investigate the effect and mechanism of CBS on 17α-ethynylestradiol (EE)-induced cholestasis in the rat. CBS (50 and 150mg/kg per day) was intragastrically (i. g.) given to experimental rats for 5 consecutive ...
Sharma Anil - - 2014
BackgroundMembers of the Semaphorin 3 family (Sema3s) influence the development of the central nervous system, and some are implicated in regulating aspects of visual system development. However, we lack information about the timing of expression of the Sema3s with respect to different developmental epochs in the mammalian visual system. In ...
Krempel Paloma G PG Laboratory for Investigation in Ophthalmology (LIM-33), University of Sao Paulo Medical School, - - 2014
Purpose: Extracellular matrix (ECM) and cellular membrane proteoglycans (PG) play important roles in neural differentiation and cell adhesion. Vascular endothelial growth factor (VEGF), an important signal protein in vascular and retinal neural cell development, is retained in the ECM due to its high affinity for PG. Bevacizumab, an anti-VEGF agent, ...
XiYing Department of Ophthalmology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, 400038, - - 2014
Aim To investigate the expression of endogenous, hypoxic stress-induced α-crystallin and caspase-3 in rat retinal neurons in vitro. Retinal neurons were cultured from Long-Evans rats. The expression of endogenous α-crystallin was analyzed by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). Furthermore, hypoxic exposure was performed in cultured cells, and the ...
Wang Yun-Guo YG Department of Orthopedics, the Second Hospital of Tianjin Medical University, Tianjin, 300211, - - 2014
P63 null mice have no or truncated limbs and mutations in human p63 cause several skeletal syndromes that also show limb and digit abnormalities, suggesting its essential role in bone development. In the current study, we investigated the effect of ATRA on chondrogenesis using mesenchymal cells from rat hind limb ...
Zeng Mian M Department of Medical Intensive Care Unit, First Affiliated Hospital of Sun Yat-sen University, 58 2nd Zhongshan Road, Guangzhou, GuangDong, 510080, People's Republic of China, - - 2014
This study investigated the effect of ghrelin on oxidative stress in septic rat lung tissue. Male Sprague-Dawley rats were divided into sham-operation, sepsis, and ghrelin groups. Sepsis was induced by cecal ligation and puncture. Ghrelin was administered intraperitoneally at 3 and 15 h post-operation. Bronchoalveolar lavage was performed to collect ...
Hanafusa Hiroyuki H Developmental Research Laboratories, Shionogi & Co., Ltd. Futaba-cho, Toyonaka, Osaka, - - 2014
Drug-induced liver injury (DILI) is a significant safety issue associated with medication use, and is the major cause of failures in drug development and withdrawal in post marketing. Cytokines are signaling molecules produced and secreted by immune cells and play crucial roles in the progression of DILI. Although there are ...
Lima Fernanda Barbosa FB Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto ( Ribeirão Preto-SP); Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Florianópolis-SC, - - 2014
The control of gonadotropin-releasing hormone (GnRH) secretion depends on the action of ovarian steroids and several substances, including nitric oxide (NO). NO in the medial preoptic area (MPOA) stimulates the proestrus surge of luteinizing hormone (LH). We studied the effect of estrogen (Tamoxifen-TMX) and progesterone (RU-486) antagonists on mRNA and ...
Rossmann Christine C Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, - - 2014
The serum amyloid A (SAA) family of proteins is encoded by multiple genes, which display allelic variation and a high degree of homology in mammals. The SAA1/2 genes code for non-glycosylated acute-phase SAA1/2 proteins, that may increase up to 1000-fold during inflammation. The SAA4 gene, well characterized in humans (hSAA4) ...
Ji Xuan Xiu XX Second Department of Geriatric Division, General Hospital of Jinan Military Region, Jinan, 250031, - - 2014
The aim of the study is to explore the effects and mechanism of the action of ligustrazine on isoprenaline-induced cardiomyocyte hypertrophy. Primary culture of neonatal rat cardiomyocytes was used as the model, and isoprenaline was used to induce cardiomyocyte hypertrophy. Effects of different dosages of ligustrazine polysaccharide on the cardiomyocyte ...
De Martin Sara S University of - - 2014
Conflicting results have been obtained by clinical studies investigating the effect of liver cirrhosis on enzyme induction. Since ethical concerns do not consent methodologically rigorous studies in humans, we addressed this question by examining the effect of the prototypical inducer dexamethasone (DEX) on the Pregnane X receptor (PXR)-mediated induction of ...
Friedmacher Florian F National Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland, - - 2014
Pulmonary hypoplasia (PH) is a serious condition in newborns with congenital diaphragmatic hernia (CDH). Lipid-containing interstitial fibroblasts (LIFs) play an essential role in fetal lung maturation by stimulating alveolarization and lipid homeostasis. In rodents, LIFs are first evident during the canalicular phase of lung development with a significant increase over ...
Wang Haitao - - 2014
Objectives: Pituitary tumor transforming gene (PTTG) is thought to play an important role in prolactinomas, and its overexpression is influenced by estrogen action in the pituitary. Changes in estrogen levels in the rat anterior pituitary increase the number of gap junctions (GJs) increasing both Connexin43 (Cx43) expression and intercellular communication, ...
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