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Yang Min M Department of Physiology, School of Basic Medical Science, Ningxia Medical University, Ningxia 750004, P.R. - - 2014
The purpose of the present study was to investigate the effects of high ambient temperature on the neuropeptide Y (NPY) mRNA level in the hypothalamus, the plasma concentration of corticotropin-releasing hormone (CRH), cortisol (Cor), heat-shock protein 70 (HSP70) and epinephrine (EPI), and the intervention of lycium barbarum polysaccharides (LBPs) in ...
van der Linde S S 1Department of Physiology,The University of - - 2014
Uteroplacental insufficiency resulting in intrauterine growth restriction has been associated with the development of cardiovascular disease, coronary heart disease and increased blood pressure, particularly in males. The molecular mechanisms that result in the programming of these phenotypes are not clear. This study investigated the expression of cardiac JAK/STAT signalling genes ...
Wang Yuhong Y Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, - - 2014
Klotho is an antiaging gene and is predominately expressed in kidneys. The endothelin system is critical in the regulation of kidney function. The objective of this study is to assess whether klotho affects the renal endothelin system in spontaneously hypertensive rats (SHRs). Four groups of male SHRs and one group ...
Cui Li-Min LM Department of Biochemistry and Molecular Biology, College of Medicine, Yanbian University, Yanji, Jilin 133002, P.R. China ; Department of Surgery, Affiliated Hospital, Yanbian University, Yanji, Jilin 133002, P.R. - - 2014
The aim of the present study was to investigate the expression of proteins associated with the sustained activation of the signal transducer and activator of transcription (STAT)-3 pathway during diethylnitrosamine (DEN)-induced rat liver carcinogenesis. DEN was intermittently administered to rats to induce liver cancer, and light and electron microscopy were ...
Miyashita Tomoharu T Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Ishikawa 920-8641, - - 2014
Animal models are important for the development of novel therapies for esophageal cancer. Histone deacetylase 1 (HDAC1)/metastasis-associated gene (MTA1) complexes inhibit p53 acetylation and thus, inhibit p53-induced apoptosis. The aim of the present study was to evaluate HDAC1 and MTA1 expression in esophageal carcinogenesis in rats. The rats underwent a ...
Wu Tao T Research Center of Chinese Medicine Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China ; Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. - - 2014
The Chinese medicinal formula, Qinggan (QG) Huoxue (HX) Recipe (R) exerts a range of pharmacological effects, including reversible steatosis, decreased levels of inflammatory cytokines and lipid peroxidation resistance. The aim of the present study was to determine the specific mechanisms of QGHXR hepatoprotection through the lipopolysaccharide-Kupffer cell (LPS-KC) signal conduction ...
Sharma Anil - - 2014
BackgroundMembers of the Semaphorin 3 family (Sema3s) influence the development of the central nervous system, and some are implicated in regulating aspects of visual system development. However, we lack information about the timing of expression of the Sema3s with respect to different developmental epochs in the mammalian visual system. In ...
Krempel Paloma G PG Laboratory for Investigation in Ophthalmology (LIM-33), University of Sao Paulo Medical School, - - 2014
Purpose: Extracellular matrix (ECM) and cellular membrane proteoglycans (PG) play important roles in neural differentiation and cell adhesion. Vascular endothelial growth factor (VEGF), an important signal protein in vascular and retinal neural cell development, is retained in the ECM due to its high affinity for PG. Bevacizumab, an anti-VEGF agent, ...
Zeng Mian M Department of Medical Intensive Care Unit, First Affiliated Hospital of Sun Yat-sen University, 58 2nd Zhongshan Road, Guangzhou, GuangDong, 510080, People's Republic of China, - - 2014
This study investigated the effect of ghrelin on oxidative stress in septic rat lung tissue. Male Sprague-Dawley rats were divided into sham-operation, sepsis, and ghrelin groups. Sepsis was induced by cecal ligation and puncture. Ghrelin was administered intraperitoneally at 3 and 15 h post-operation. Bronchoalveolar lavage was performed to collect ...
Hanafusa Hiroyuki H Developmental Research Laboratories, Shionogi & Co., Ltd. Futaba-cho, Toyonaka, Osaka, - - 2014
Drug-induced liver injury (DILI) is a significant safety issue associated with medication use, and is the major cause of failures in drug development and withdrawal in post marketing. Cytokines are signaling molecules produced and secreted by immune cells and play crucial roles in the progression of DILI. Although there are ...
Lima Fernanda Barbosa FB Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto ( Ribeirão Preto-SP); Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Florianópolis-SC, - - 2014
The control of gonadotropin-releasing hormone (GnRH) secretion depends on the action of ovarian steroids and several substances, including nitric oxide (NO). NO in the medial preoptic area (MPOA) stimulates the proestrus surge of luteinizing hormone (LH). We studied the effect of estrogen (Tamoxifen-TMX) and progesterone (RU-486) antagonists on mRNA and ...
Rossmann Christine C Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, - - 2014
The serum amyloid A (SAA) family of proteins is encoded by multiple genes, which display allelic variation and a high degree of homology in mammals. The SAA1/2 genes code for non-glycosylated acute-phase SAA1/2 proteins, that may increase up to 1000-fold during inflammation. The SAA4 gene, well characterized in humans (hSAA4) ...
Ji Xuan Xiu XX Second Department of Geriatric Division, General Hospital of Jinan Military Region, Jinan, 250031, - - 2014
The aim of the study is to explore the effects and mechanism of the action of ligustrazine on isoprenaline-induced cardiomyocyte hypertrophy. Primary culture of neonatal rat cardiomyocytes was used as the model, and isoprenaline was used to induce cardiomyocyte hypertrophy. Effects of different dosages of ligustrazine polysaccharide on the cardiomyocyte ...
De Martin Sara S University of - - 2014
Conflicting results have been obtained by clinical studies investigating the effect of liver cirrhosis on enzyme induction. Since ethical concerns do not consent methodologically rigorous studies in humans, we addressed this question by examining the effect of the prototypical inducer dexamethasone (DEX) on the Pregnane X receptor (PXR)-mediated induction of ...
Friedmacher Florian F National Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland, - - 2014
Pulmonary hypoplasia (PH) is a serious condition in newborns with congenital diaphragmatic hernia (CDH). Lipid-containing interstitial fibroblasts (LIFs) play an essential role in fetal lung maturation by stimulating alveolarization and lipid homeostasis. In rodents, LIFs are first evident during the canalicular phase of lung development with a significant increase over ...
Wang Haitao - - 2014
Objectives: Pituitary tumor transforming gene (PTTG) is thought to play an important role in prolactinomas, and its overexpression is influenced by estrogen action in the pituitary. Changes in estrogen levels in the rat anterior pituitary increase the number of gap junctions (GJs) increasing both Connexin43 (Cx43) expression and intercellular communication, ...
Zhou Da-An - - 2014
Glucocorticoid has been used extensively in clinical applications, because of its several pharmacologic actions, which include immunosuppression, anti-inflammation, anti-shock, and relief of asthma. However, the long-term or high-dose application of glucocorticoid can induce adverse effects such as osteoporosis, which is known in this case as glucocorticoid-induced osteoporosis (GIOP). It is ...
Clark Peter J PJ Integrative Physiology University of Colorado Boulder 354 UCB Boulder, CO 80309. Electronic address: - - 2014
Emerging evidence indicates that adenosine is a major regulator of striatum activity, in part, through the antagonistic modulation of dopaminergic function. Exercise can influence adenosine and dopamine activity, which may subsequently promote plasticity in striatum adenosine and dopamine systems. Such changes could alter activity of medium spiny neurons and impact ...
Fan Xiaomei X School of Pharmaceutical Sciences, Sun Yat-sen - - 2014
Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury. Compensatory liver regeneration is crucial for the final outcome of toxicant-induced injury. However, the molecular mechanisms underlying compensatory liver regeneration in mice after APAP-induced liver injury are not completely understood. This study aimed to investigate the role of dynamic ...
Perra Andrea A Department of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, - - 2014
Although the growth suppressor Hippo pathway has been implicated in hepatocellular carcinoma (HCC) pathogenesis, it is unknown at which stage of hepatocarcinogenesis its dysregulation occurs. We investigated in early rat and human preneoplastic lesions whether overexpression of the transcriptional co-activator Yes-associated protein (YAP) is an early event. The experimental model ...
Roseni Mundstock Dias Glaecir G Programa de Pós-Graduação em Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular Universidade Federal de Santa Maria, Santa Maria, RS, - - 2014
Introduction: Cellular antioxidant signaling can be altered either by thyroid disturbances or by selenium status. Aims: To investigate whether or not dietary diphenyl diselenide could modify the expression of genes of antioxidant enzymes and endpoint markers of oxidative stress under hypothyroid condition. Methods: Female rats were rendered hypothyroid by continuous ...
Wang Fengmei F Department of Obstetrics and Gynaecology, Fuzhou General Hospital, Fuzhou, Fujian 350025, P.R. - - 2014
Autophagy has a significant role in myocardial injury induced by lipopolysaccharide (LPS). Estrogen (E2) has been demonstrated to protect cardiomyocytes against apoptosis; however, it remains to be determined whether it exhibits anti‑autophagic effects. The aim of the present study was to investigate whether estrogen-regulated autophagy attenuates cardiomyocyte injury induced by ...
Huang Qiong Q Department of Geratology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, - - 2014
Insulin resistance, diabetes and many kinds of cancers are common in overweight and obese individuals. The tumor suppressor p53 is important in securing genetic stability, but its role in the regulation of metabolic processes and cell differentiation remains unclear. We have investigated the role of p53 in adipocyte differentiation. Using ...
Oenarto Jessica J Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine University, Düsseldorf, - - 2014
This study characterizes the expression of the osmolyte transporters betaine/γ-amino-n-butyric acid (GABA) transporter (BGT-1), the taurine transporter (TauT) and the sodium-dependent myo-inositol transporter (SMIT) in various rat brain cells in culture and in rat and human cerebral cortex in situ. Osmolyte transporter expression greatly differed between cultured brain cells with ...
Mao Yuanjie Y aDepartment of Cardiology, Peking University First Hospital, Beijing, China bDepartment of Biochemistry, National Cerebral and Cardiovascular Center, Osaka, Japan cCardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, USA dDepartment of Endocrinology, Beijing Aerospace Center Hospital eDepartment of Physiology, School of Basic Medical Sciences, Peking University, Beijing, - - 2014
The activation of Gq-protein-coupled receptors induces proliferation of vascular smooth muscle cells (VSMCs) proliferation and is involved in vascular remodeling. The regulator of G protein signaling 2 (RGS2), which accelerates the termination of Gq protein signaling, may play a role in vascular remodeling. However, this role remains unclear. Aortic balloon ...
Xu Lijun L Department of Urinary Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. - - 2014
The aim of the present in vivo study was to determine the presence of muscle-derived stem cells (MDSCs) in the corpus cavernosum of rats. Immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR) were performed to detect the expression of the stem cell markers stem cell antigen-1 (Sca-1), Oct4 and Desmin ...
Carloni Silvia S Department of Biomolecular Sciences, University of Urbino "Carlo Bo", Via S. Chiara 27, 61029, Urbino, - - 2014
Conditions that interfere with the endoplasmic reticulum (ER) functions cause accumulation of unfolded proteins in the ER lumen, referred to as ER stress and activate a homeostatic signaling network known as unfolded protein response (UPR). We have previously shown that in neonatal rats subjected to hypoxia-ischemia (HI) melatonin administration significantly ...
Zhou Qing-Zhong QZ Department of Spine Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, - - 2014
To investigate the effect of the spinal cord extracts (SCE) after spinal cord injuries (SCIs) on the proliferation of rat embryonic neural stem cells (NSCs) and the expressions of mRNA of Notch1 as well as of Hes1 in this process in vitro. The experiment was conducted in 4 different mediums: ...
Rezaei Mina M From the Department of Nephrology, Hypertension, and Clinical Pharmacology (M.R., T.A., D.M., F.J.F., B.V., B.M.F.) and Department of Biology and Bioinformatics (S.N., R.B.), University of Bern, Bern, Switzerland; Vital-IT, Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland (S.N.); and Department of Clinical Research, University Hospital Bern, Bern, Switzerland - - 2014
The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) is selectively expressed in aldosterone target tissues, conferring aldosterone selectivity for the mineralocorticoid receptor. A diminished activity causes salt-sensitive hypertension. The mechanism of the variable and distinct 11β-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) expression in the cortical collecting duct is poorly understood. Here, ...
Yang Wen W School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, PR China; Biopharmaceutical Research Institute, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, PR China. Electronic address: - - 2014
Mesencephalic astrocyte-derived neurotrophic factor (MANF) has been shown to be up-regulated under the focal cerebral ischemia and protected against ischemic injury in rats. However, the underlying mechanisms are unclear. The aim of this study was to verify the protection of MANF on the cerebral ischemic injury and further investigate the ...
Mills A M AM Imperial College London, National Heart and Lung Institute (NHLI), London, United - - 2014
Changes to the cellular expression of numerous microRNAs (miRs) have been implicated in disease development. MiR-1 expression is down-regulated in human heart failure (HF) and our in vivo rat HF model, we aimed to further understand its significance in HF. We previously showed that miR-1 expression was restored by in ...
Kasparova D D Charles University of Prague , Faculty of Science, Department of Physiology, Prague, Czech - - 2014
 We have shown that long-term adaptation to intermittent normobaric hypoxia (INH) or to intermittent hypobaric hypoxia (IHH) for 8 h per day improves myocardial tolerance to acute ischemia-reperfusion injury. Reactive oxygen species formed during hypoxic exposures play an important role in the induction of protective cardiac phenotype.  Adult male Wistar ...
Frimmel K K Slovak Academy of Sciences, Institute for Heart Research, Bratislava, Slovak - - 2014
The aim of our study was to investigate the effect of omega-3 fatty acids (FA) on expression of connexin40 (Cx40) in rat aorta during inflammation. Cxs are proteins of gap junction channels which regulate homeostasis and vasomotion through direct intercellular communication. FA are known for their anti-inflammatory and beneficial effects ...
Kim Kyung-Hyun KH Catholic University of Daegu, College of Medicine, Department of Pathology, Daegu, Korea, Republic of ; - - 2014
Epithelial-mesenchymal transition (EMT) has been implicated in embryonic development, fibrosis, and tumor metastasis. Nuclear factor (NF)-κB plays a central role in coordinating the inflammatory and wound healing responses during liver fibrogenesis. However, the involvement of NF-κB during EMT in liver cells remains unidentified. To develop a therapeutic approach for EMT ...
Ma Yan-Min - - 2014
Androgen therapy is the mainstay of treatment for the hypogonadotropic hypogonadal micropenis because it obviously enhances penis growth in prepubescent microphallic patients. However, the molecular mechanisms of androgen treatment leading to penis growth are still largely unknown. To clarify this well-known phenomenon, we successfully generated a castrated male Sprague Dawley ...
Wei Ming M Department of Neurosurgery, the Second Hospital, Tianjin Medical University, Tianjin 300211, China; Tianjin Huanhu Hospital, Tianjin 300060, - - 2014
The extracellular matrix metalloproteinase inducer (EMMPRIN), or CD147, has been known to play a key regulatory role in vascular permeability and leukocyte activation by inducing the expression of matrix metalloproteinases (MMPs). The effects of traumatic brain injury on the expression of EMMPRIN remain poorly understood. In this study, we investigated ...
Ko Wai Kin D WK Faculty of Life Sciences, University of Manchester, Manchester, UK; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France. Electronic address: - - 2014
Regulators of G-protein signalling (RGS) proteins are implicated in striatal G-protein coupled receptor (GPCR) sensitisation in the pathophysiology of L-DOPA-induced abnormal involuntary movements (AIMs), also known as dyskinesia (LID), in Parkinson's disease (PD). In this study, we investigated RGS protein subtype 4 in the expression of AIMs in the unilateral ...
Murphy Stephanie J SJ Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, - - 2014
There are important sex differences in the risk and outcome of conditions and diseases between males and females. For example, stroke occurs with greater frequency in men than in women across diverse ethnic backgrounds and nationalities. Work from our lab and others have revealed a sex-specific sensitivity to cerebral ischemia ...
An Jun J Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an 710032, - - 2014
MiRNAs have been found to contribute to normal brain functions, nervous system diseases, as well as neurotoxicities induced by external agents. However, whether they are involved in lead-induced neurotoxicities is still not clear. To identify that, a lead-induced chronic neurotoxicity model of rats was built. Both miRNA microarray analysis and ...
Brandenburger Timo T 1 Department of Anesthesiology, University Hospital Duesseldorf, 40225 Duesseldorf, Germany 2 Hadassah Medical School, Hebrew University of Jerusalem, Jerusalem, - - 2014
Remote ischemic preconditioning (RIPC) is an easily applicable method for protecting the heart against a subsequent ischemia and reperfusion (I/R) injury. However, the exact molecular mechanisms underlying RIPC are unknown. We examined the involvement of microRNAs (miRNAs) and in particular the expression of miR-1 in RIPC and myocardial ischemia. RIPC ...
Pisar Mazura M Institute of Neuroscience and Psychology, West Medical Building, University of Glasgow, Glasgow G12 8QQ, - - 2014
Inhibition of the kynurenine pathway of tryptophan metabolism during gestation can lead to changes in synaptic transmission, neuronal morphology and plasticity in the rat hippocampus. This suggests a role for the kynurenine pathway in early brain development, probably caused by kynurenine modulation of N-methyl-D-aspartate (NMDA) glutamate receptors which are activated ...
Cui Lei L Department of Radiology, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, - - 2014
Emerging evidence indicates that Wnt/β-catenin pathway is linked to the fibrosis of different organs including liver fibrosis. β-Catenin promotes hepatic stellate cells (HSCs) activation, a key event in the development of liver fibrosis, and has emerged as a novel mediator of fibrosis. Curcumin, a natural active ingredient derived from turmeric, ...
Nickel Sabrina S Department of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg , Heidelberg , - - 2014
Abstract 1. Breast cancer resistance protein (BCRP) is an ABC-transporter at the blood-brain barrier (BBB) facilitating efflux of xenobiotics into blood. Expression and function are regulated via estrogen-receptors (ERs). 2. 17α-Ethinylestradiol (EE2) and bisphenol A (BPA) represent two prominent xenoestrogens. We studied whether EE2 and BPA regulate BCRP function and ...
Guo Xian Jun XJ CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, - - 2014
Although permanent bilateral common carotid artery occlusion (2VO) has been demonstrated to induce retinal injury, there is still a lack of systematic research on the complex processing of retinal degeneration. In the present study, time-dependent (at three, 14, 60 days after 2VO surgery) changes of neurotrophic and inflammatory systems, as ...
Meir Tomer T Department of Nephrology, Hadassah Hebrew University Medical Center, Jerusalem, - - 2014
Parathyroid hormone (PTH) increases FGF23 mRNA and protein levels in vivo and in vitro. Here we tested whether the increased FGF23 expression by PTH is mediated by the orphan nuclear receptor Nurr1. PTH increased Nurr1 mRNA levels prior to elevation of FGF23 mRNA levels in UMR-106 rat osteoblast-like cells. Activation ...
Das Rajat Kumar RK Laboratories of Biochemistry, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, - - 2014
We proposed to determine whether, like other sexual dimorphisms, drug metabolism is permanently imprinted by perinatal hormones, resulting in its irreversible sex-dependent expression. We treated newborn male rats with monosodium glutamate (MSG), a total growth hormone (GH) blocker, and, using cultured hepatocytes, examined expression of adult CYP2C11, the predominant cytochrome-P450 ...
Rizzo Francesca F Laboratory of Molecular Medicine and Genomics, Department of Medicine and Surgery, University of Salerno, Baronissi, - - 2014
Small non-coding RNAs comprise a growing family of molecules that regulate key cellular processes including mRNA degradation, translational repression and transcriptional gene silencing. PIWI-interacting RNAs (piRNAs) represent a class of small RNAs initially identified in the germline of a variety of species, where they contribute to maintenance of genome stability, ...
Marzioni Marco M Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, - - 2014
Background/aims: The activation of the biliary stem-cell signalling pathway Hes-1/PDX-1 in mature cholangiocytes determines cell proliferation. Neurogenin-3 (Ngn-3) is required for pancreas development and ductal cell neogenesis. PDX-1-dependent activation of Ngn-3 initiates the differentiation program, by inducting microRNA (miR)-7 expression. Here, we investigated the role Ngn-3 on cholangiocyte proliferation. Methods: ...
Chabot Andréanne A Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada; Département de Physiologie, Université de Montréal, Montréal, Québec, - - 2014
Upregulation of the intermediate filament protein nestin was identified in a subpopulation of fibroblasts during reactive and reparative fibrosis and directly contributed to the enhanced proliferative phenotype. The present study tested the hypothesis that nestin was expressed in lung fibroblasts and the pattern of expression represented a distinct marker of ...
Li En-Hui EH Department of Urology, Shanghai First People's Hospital affiliated to Shanghai Jiaotong University, 100 Haining road, Shanghai 200080, - - 2014
Abstract Mounting evidence has indicated the crucial role of Wnt5a in embryonic development including guts. However, the Wnt5a involvement in the process of anorectal malformations (ARMs) remains unclear. In this study, we examined the expression of Wnt5a during ARMs development in the offspring of di(n-butyl) phthalate (DBP)-treated pregnant rats. During ...
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