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Li Yuhong Y Department of Neonatology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, 223300, Jiangsu, People's Republic of - - 2014
Alveolar type I epithelial cells (AECIs) play an important role in the pathogenesis of acute lung injury. The receptor for advanced glycation end-products (RAGEs) is expressed at a high basal level in AECIs, and its soluble isoform is suggested as a marker of AECI injury. However, the molecular mechanism by ...
Chalmel Frédéric - - 2014
Mammalian spermatogenesis is a complex and highly orchestrated combination of processes in which male germline proliferation and differentiation result in the production of mature spermatozoa. If recent genome-wide studies have contributed to the in-depth analysis of the male germline protein-coding transcriptome, little effort has yet been devoted to the systematic ...
Wang Fei F 1Sun Yat-sen - - 2014
(Pro)renin receptor (PRR) is predominantly expressed in the distal nephron where it is activated by angiotensin II (AngII), resulting in increased renin activity in the renal medulla thereby amplifying the de novo generation and action of local AngII. The goal of the present study was to test the role of ...
Irles Claudine C Departamento de Fisiología, Facultad de - - 2014
Abstract We have previously reported that in response to early life stress, such as maternal hyperthyroidism and maternal separation (MS), the rat hypothalamic vasopressinergic system becomes up-regulated, showing enlarged nuclear volume and cell number, with stress hyperresponsivity and high anxiety during adulthood. The detailed signaling pathways involving cell death/survival, modified ...
Pérez-Girón Jose V JV Universidad Rey Juan - - 2014
Glitazones have anti-inflammatory properties by interfering with transcription of pro-inflammatory genes such as COX-2 and with reactive oxygen species (ROS) production, which are increased in hypertension. This study analyzes whether pioglitazone modulates COX-2 expression in hypertension by interfering with ROS and endothelin-1. In vivo, pioglitazone (2.5 mg•Kg(-1)•day(-1), 28 days) reduced ...
Feng H J HJ Zhujiang Hospital, Department of Nuclear Medicine, Southern Medical University, Guangzhou, - - 2014
Hypertrophy is a major predictor of progressive heart disease and has an adverse prognosis. MicroRNAs (miRNAs) that accumulate during the course of cardiac hypertrophy may participate in the process. However, the nature of any interaction between a hypertrophy-specific signaling pathway and aberrant expression of miRNAs remains unclear. In this study, ...
Spasova Mariya S MS Department of Pediatrics, The Alpert Medical School of Brown University, Women & Infants Hospital of Rhode Island, Providence, RI 02905, - - 2014
Inter-alpha inhibitor proteins (IAIPs) found in relatively high concentrations in human plasma are important in inflammation. IAIPs attenuate brain damage in young and adult subjects, decrease during sepsis and necrotizing enterocolitis in premature infants, and attenuate sepsis-related inflammation in newborn rats. Although a few studies have reported adult organ-specific IAIP ...
Sancho Maria M Department of Physiology, School of Veterinary Medicine, Complutense University, and Instituto Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Madrid, - - 2014
Increased nitric oxide (NO) production seems to play a key role in cyclophosphamide (CYP)-induced cystitis, although the underlying mechanisms and the relative involvement of the different NO synthase (NOS) isoforms remain to be elucidated. Moreover, the role of the urethra in this process is also unclear. In this study, we ...
Chanyshev M D MD Institute of Molecular Biology and Biophysics, Siberian Branch of Russian Academy of Medical Sciences, Timakova 2, Novosibirsk, 630117 - - 2014
In this study, we determined the expression level of miRNAs and the induction of CYP1A1 and CYP2B1 in the livers and ovaries of female Wistar rats treated with DDT, benzo[a]pyrene (BP), and 3-methylcholanthrene (MC). This study compared CYP1A/2B induction and miRNA expression levels to cast light on a possible role ...
Ding Tao T Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People's Republic of - - 2014
Transcription factor IID (TFIID), as a general transcription factor, plays a pivotal role in the preinitiation complex (PIC) assembly and transcription initiation by recruiting RNA polymerase II to the promoter. The TFIID complex contains the TATA-box binding protein (TBP) and a group of conserved TAF proteins. However, its distribution and ...
Chen Jing-Jing JJ Key Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, University of South China, Hengyang, 421001, Hunan, People's Republic of - - 2014
Vascular calcification (VC) is highly associated with increased morbidity and mortality in patients with advanced chronic kidney disease. Paracrine/autocrine factors such as vasoactive peptides are involved in VC development. Here, we investigated the expression of the novel peptide C-type natriuretic peptide (CNP) in the vasculature, tested its ability to prevent ...
Zhou Hua-Jun - - 2014
Angiopoietin (Ang) is one of the major effectors of angiogenesis, playing a critical role in neurovascular remodeling after stroke. Acupuncture has been widely used for treating stroke in China for a long time. Recently, we have demonstrated that electroacupuncture (EA) can accelerate intracerebral hemorrhage (ICH)-induced angiogenesis in rats. In the ...
Raucci Franca F Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università di Napoli, Via Vivaldi 43, 81100 Caserta, Italy; Reproductive and DevelopmentalBiology Laboratory, Department of Health, Animal Science and Food Safety - University of Milan, Via Celoria, 10 - 20133 Milano, Italy. Electronic address: - - 2014
Previous studies have shown a role of D-aspartic acid (D-Asp) in testicular steroidogenesis. Here, we evaluated the effects of D-Asp on androgen production and on expression levels of mRNAs encoding specific steroidogenic key molecules. D-Asp was endogenously present in adult rat testis and its content paralleled to serum luteinizing hormone ...
Tenkumo Kaori K Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793 - - 2014
The purpose of this study was to investigate the effect of the renin inhibitor, aliskiren, on retinal ischemia-reperfusion injury. Retinal ischemia was induced by increasing intraocular pressure to 130 mmHg. At 7 days after ischemia, retinal damage was evaluated by measuring the retinal thickness and the number of retinal ganglion ...
Zhang Dongmei D Department of Pathogen Biology, Medical School, Nantong University, Nantong, 226001, People's Republic of China; Basic Medial Research Center, Medical School, Nantong University, Nantong, 226001, People's Republic of - - 2014
The Glycinamide ribonucleotide transformylase (GART) gene, a trifunctional polypeptide, has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, and phosphoribosylaminoimidazole synthetase activity, and is required for de novo purine biosynthesis. GART is highly conserved in vertebrates. Alternative splicing of GART results in two transcript variants encoding different isoforms. However, the expression and function of ...
Wang Zhen-Chang ZC Liver Disease Center, First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Naning 530023, China. Electronic address: - - 2014
To investigate the impact of bone marrow mesenchymal stem cells on Smad expression of hepatic fibrosis rats. A total of 48 adult female SD rats were randomly divided into three groups, normal control group (n=10), observation group (n=19) with liver fibrosis model rats injected with BMSCs cells; model group (n=19), ...
Sun Yu'e Y From the Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, - - 2014
Hyperalgesia and neuroinflammation are associated with glia, which consists of macroglia and microglia. In this study, we used a selective cannabinoid receptor type 2 (CB2) agonist JWH015 to investigate remifentanil-induced postoperative hyperalgesia. Mechanical allodynia and thermal hyperalgesia after postoperative hyperalgesia and intrathecal injection of JWH015 were assessed by the paw ...
Zhang Zhaohui Z Department of Psychosomatic Medicine, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, P.R. China ; Department of Neurology, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, P.R. - - 2014
Neuronal Per-Arnt-Sim domain protein 4 (NPAS4) is important in regulating transcription and function in the limbic system and in brain development. Post-stroke depression (PSD) is a common complication following a stroke. Furthermore, organic damage as a result of a stroke affects the restoration of nerve function and indicates that hippocampal ...
Cui Yan Y Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. - - 2014
In the current study, microRNA (miRNA) microarrays were used to detect differentially expressed miRNAs in the myocardial tissues of rat models under stress, to screen target miRNA candidates for miRNA therapy of stress-induced myocardial injury. Rats were bound and suspended in order to induce acute stress (AS) and chronic stress ...
Fu Rong R Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China, - - 2014
Aminoacyl-tRNA syntheses (AARS) can catalyze the adenosine triphosphate (ATP)-dependent acylation of their cognate tRNA(s) with a specific amino acid. They can be seen as an index to reflect the energy metabolic rate of ischemic brain cells in ischemic penumbra. This study examined the relationship between arginyl-tRNA synthetase (ArgRS), one of ...
Su Hong H Second Hospital of Shangdong University, Jinan, - - 2014
Because alternative RNA splicing regulation in the testis is prevalent, we explored testes of Sprague-Dawley rats for existence of alternatively spliced colony-stimulating factor 1 receptor (CSF-1R) mRNA. Using RT-PCR and sequencing, we identified a variant of CSF-1R mRNA that was 284 bp shorter than the full-length CSF-1R transcript. This variant was ...
Castellano Juan Manuel JM Division of Neuroscience, Oregon National Primate Research Center-Oregon Health and Science University, Beaverton Oreg., - - 2014
The importance of the Kiss1 gene in the control of reproductive development is well documented. However, much less is known about the transcriptional regulation of Kiss1 expression in the hypothalamus. Critical for these studies is an accurate identification of the site(s) where Kiss1 transcription is initiated. Employing 5'-RACE PCR we ...
Habib Pardes P Institute of Neuroanatomy, RWTH Aachen University, Aachen, - - 2014
17β-estradiol (E2) and progesterone (P) are neuroprotective in acute brain injury by attenuating neuropathophysiological processes and regulating local glial function. Besides controlling brain-intrinsic immune responses, astrocytes are cellular targets for sex steroids in health and disease and typically resist to hypoxic damage. In this in vitro study, we aimed at ...
Zhao Min M Department of Pathophysiology, Medical School of Nantong University, - - 2014
This study investigated a possible role for a toll-like receptor 4 (TLR4)-mediated PTEN/PI3K/AKT/NF-κB signaling pathway in neuroinflammation in rat hippocampal neurons. Cultured neurons were treated with lipopolysaccharide (LPS), a TLR4 ligand, or pre-treated with TLR4 antibodies to block TLR4 signaling. Neurons were also treated with dipotassium bisperoxo (pyridine-2-carboxyl) oxovanadate [bpV(pic)] ...
Tapocik Jenica D JD Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland - - 2014
Escalation of voluntary alcohol consumption is a hallmark of alcoholism, but its neural substrates remain unknown. In rats, escalation occurs following prolonged exposure to cycles of alcohol intoxication, and is associated with persistent, wide-ranging changes in gene expression within the medial prefrontal cortex (mPFC). Here, we examined whether induction of ...
Camós Susanna S Institut d'Investigació Biomèdica de Girona (IdIBGi), Grup Cerebrovascular - Servei de Neurologia. Hospital Universitari de Girona Dr. Josep Trueta, Av. França s/n. 17007, Girona, Spain. Electronic address: - - 2014
The present study aims to identify transcription factors (TFs) contributing to angiogenesis, a mechanism involved in giving plasticity to the brain, as potential therapeutic targets after cerebral ischaemia. The promoter sequence from candidate genes involved in angiogenesis were submitted to a comparative analysis by bioinformatics software. HMGIY TF characterisation in ...
Xu Min M 1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China; 2Department of General and Visceral Surgery, University Medical Center Goettingen, Goettingen, Germany; 3Department of Gastroenterology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; 4Department of Surgery, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, People's Republic of China; 5Shanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, People's Republic of - - 2014
Acute rejection (AR) and acceptance of allograft after liver transplantation (LTx) remain critical issues that need addressing to improve prognosis. Therefore we performed rat orthotopic LTx and proteomic analyses to screen for immune response-related biomarkers in sera. Markers identified were validated at the mRNA and/or protein levels and the molecules ...
Jesus Tito T TT CICS - UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, - - 2014
Sertoli cells (SCs) form the blood-testis barrier (BTB) that controls the microenvironment where the germ cells develop. The cystic fibrosis transmembrane conductance regulator (CFTR) plays an essential role to male fertility and it was recently suggested that it may promote water transport. Interestingly, Aquaporin-4 (AQP4) is widely expressed in blood ...
Kassis Haifa H Department of Neurology, Henry Ford Health System, Detroit, MI - - 2014
Histone deacetylases (HDACs) constitute a super-family of enzymes grouped into four major classes (Class I-IV) that deacetylate histone tails leading to chromatin condensation and gene repression. Whether stroke-induced oligodendrogenesis is related to the expression of individual HDACs in the oligodendrocyte lineage has not been investigated. We found that 2 days ...
Wu Tongde T Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, - - 2014
Increased endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) are the salient features of end-stage liver diseases. Using liver tissues from liver cirrhosis patients, we observed up-regulation of the XBP1-Hrd1 arm of the ER stress response pathway and down-regulation of the Nrf2-mediated antioxidant response pathway. We further confirmed this ...
Yin Hai-Yan HY Department of Intensive Care Unit (H-YY, RZ, X-LY, Y-FZ, W-JL), and Cardiology (J-RW), Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, - - 2014
: Apoptosis and caspase-3 play an important role in the pathogenesis of sepsis. In this study, the authors monitored myocardial apoptosis and investigated caspase-3 protein expression change in rats with sepsis. In addition, we investigated the protective effect of glutamine (Gln) on myocardial injury in septic rats. A rat model ...
Shimogawa Yuji Y Neuroendocrinology, Department of Human Behaviour and Environment Sciences, Faculty of Human Sciences, Waseda University, 2-579-15, Mikajima, Tokorozawa, Saitama, 359-1192, - - 2014
To elucidate the relationship between right and left sides of the ventrolateral ventromedial hypothalamic nucleus (vlVMN) in regulating expression of oestrogen receptor (ER) α, unilateral vlVMN was lesioned and the number of ERα-immunoreactive cells and ERα mRNA level in the intact side of the vlVMN and arcuate nucleus (ARCN) were ...
Gubern Carme C Grup de Recerca Cerebrovascular, Servei de Neurologia, Institut d'Investigació Biomèdica de Girona (IdIBGi) Dr. Josep Trueta, Hospital Universitari de Girona Dr. Josep Trueta, Av de França s/n, 17007 Girona, Spain. Electronic address: - - 2014
Lrrfip1 is an up-regulated protein after cerebral ischaemia whose precise role in the brain both in healthy and ischaemic conditions is unclear. Different Lrrfip1 isoforms with distinct roles have been reported in human and mouse species. The present study aimed to analyse the Lrrfip1 transcriptional variants expressed in rat cortex, ...
Mor Eyal E Sackler Faculty of Medicine, Tel-Aviv University, 69978, Tel Aviv, Israel, - - 2014
The tumor suppressor protein p53 is a powerful regulator of the embryo's susceptibility to diverse teratogenic stimuli, functioning both as a teratogenesis inducer and suppressor. However, the targets that p53 engages to fulfill its functions remain largely undefined. We asked whether the microRNA (miRNA) miR-34 family, identified as one of ...
Nozawa Kaori K Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, - - 2014
Neonatal exposure to synthetic estrogen causes delayed reproductive dysfunction in female rats. Exposure to 17α-ethynyl estradiol (EE, low: 20 and high: 2000μg/kg) induced an abnormal estrous cycle during PND171-190 in low-dose and PND126-145 in high-dose group. At PND90 within normal estrous cycle, high-dose animals showed lack of LH surge and ...
Machida Takuji T Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan. Electronic address: - - 2014
Elevated mechanical stress applied to vascular walls is well known to modulate vascular remodeling. We investigated the effect of pulsatile pressure stress on NO production and inducible nitric oxide (iNOS) expression by interleukin-1β (IL-1β) stimulation in rat vascular smooth muscle cells (VSMCs). VSMCs were enzymatically isolated from aortic media of ...
Serizawa Kenichi K Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, - - 2014
Background and Aims: Cardioprotective effects induced by delayed ischemic preconditioning and by nicorandil are mediated via expression of cardioprotective factors such as COX-2. The present study was undertaken to evaluate whether nicorandil could induce COX-2 in rats and to elucidate its mode of induction pharmacologically. Methods and Results: Three hours ...
Silvestre M F P MF Centre for Diabetes, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London, London, - - 2014
An adverse intra-uterine environment, induced by maternal consumption of diets high in saturated fat or low in protein have been implicated as a potential trigger for development of metabolic disease in later life. However, the underlying mechanisms responsible for this programming of obesity have yet to be described. Recent studies ...
Liu Q Q School of Pharmaceutical Sciences, Binzhou Medical University , Yantai, Shandong , PR China - - 2014
Abstract Context: One approach to protect against liver fibrosis is the use of herb-derived natural compounds, such as hydroxysafflor yellow A (HSYA). The antifibrosis effect of HYSA against liver fibrosis has been investigated; however, its mechanisms have not yet been entirely revealed. Objectives: To study the protective effects of HSYA ...
Greenwood Mingkwan M School of Clinical Sciences, University of Bristol, Bristol BS1 3NY, United Kingdom, Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo 14801-385, Brazil, School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom, and Department of Physiology, University of Malaya, Kuala Lumpur 50603, - - 2014
Arginine vasopressin (AVP) is a neurohypophysial hormone regulating hydromineral homeostasis. Here we show that the mRNA encoding cAMP responsive element-binding protein-3 like-1 (CREB3L1), a transcription factor of the CREB/activating transcription factor (ATF) family, increases in expression in parallel with AVP expression in supraoptic nuclei (SONs) and paraventicular nuclei (PVNs) of ...
Blazquez Alba G AG Laboratory of Experimental Hepatology and Drug Targeting (HEVEFARM), IBSAL, University of Salamanca, Salamanca, Spain; Instituto de Salud Carlos III, CIBERehd, Madrid, Spain. Electronic address: - - 2014
Acetaminophen is used as first-choice drug for pain relief during pregnancy. Here we have investigated the effect of acetaminophen at subtoxic doses on the expression of ABC export pumps in trophoblast cells and its functional repercussion on the placental barrier during maternal cholestasis. The incubation of human choriocarcinoma cells (JAr, ...
Goto Gentaro G Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, - - 2014
General anesthesia is commonly used in the surgical arena, but little is known regarding its influence at the genomic and molecular levels. MicroRNAs (miRNAs) belong to a new class of non-coding RNA molecules which influence cell biology. In the present study, it was hypothesized that miRNAs alter gene expression levels ...
Ho Tin-Yun TY Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, - - 2014
Uncaria rhynchophylla (UR) has been used for the treatment of convulsions and epilepsy in traditional Chinese medicine. This study reported the major anti-convulsive signaling pathways and effective targets of UR and rhynchophylline (RP) using genomic and immunohistochemical studies. Epileptic seizure model was established by intraperitoneal injection of kainic acid (KA) ...
Darwish Wageh Sobhy WS Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18, W9, Kita-ku, Sapporo, 060-0818, - - 2014
Copper (Cu(2+)) is an essential element that plays important roles in physiological functions of the body. However, high Cu(2+) levels can have toxic implications. This study aims to investigate the constitutive response to Cu(2+) exposure of xenobiotic-metabolizing enzymes in cultured rat liver (H4-II-E) cell lines. Rat cells were exposed to ...
Wittmann Gábor G Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Tupper Research Institute, Tufts Medical Center, Boston, MA - - 2014
Thyroid hormone regulates immune functions and has anti-inflammatory effects. In promoter assays, the thyroid hormone-activating enzyme, type 2 deiodinase (D2), is highly inducible by the inflammatory transcription factor nuclear factor-kappa B (NF-κB), but it is unknown if D2 is induced in a similar fashion in vivo during inflammation. We first ...
Li Wen W Stomatology Hospital affiliated to Medical College, Zhejiang University, - - 2014
To study the expression of ADAMTs-5 and TIMP-3 in temporomandibular joint osteoarthritis (TMJOA) model rats, to explore and confer the possible effects of ADAMTs-5 and TIMP-3 involved in the degradation of the early stage of OA. 32 SD rats were divided into four groups: 2-week control group (NC1), 2-week OA ...
Lu Hai-Feng HF Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China, Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, Hubei 430030, China, and The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, Hubei 430030, - - 2014
Many studies have reported a withdrawal-dependent increase in synaptic AMPA receptor (AMPAR) levels in the nucleus accumbens (NAc) of cocaine-sensitized rats; however, the exact relationship between the expression of sensitization and altered AMPAR surface expression in the NAc has not yet been investigated. We demonstrated that the expression of behavioral ...
Cho Kyu Suk KS Department of Neuroscience and Institute of Functional Genomics, Department of Pharmacology, School of Medicine, Konkuk University, 1 Hwayang-Dong, Gwangjin-Gu, Seoul 143-701, Korea. - - 2014
Resveratrol (3,5,4'-trihydroxy-trans-stilbene, RSV) is a polyphenolic compound present in a variety of plant species (including grapes) that produces a myriad of biological activities including anti-inflammatory, antioxidant and neuroprotective effects. In this study, we investigate the effects of resveratrol on the basal and glutamate-stimulated expression and activity of a tissue plasminogen ...
Yamagata Kazuo K Department of Food Bioscience and Biotechnology, College of Bioresource Sciences, Nihon University (NUBS), Japan.; Advance Research Center on Food Function, College of Bioresource Science, NihonUniversity (NUBS), Japan. Electronic address: - - 2014
In stroke-prone spontaneously hypertensive rats (SHRSP/Izm), ischemia induces swelling of astrocytes, a process that subsequently leads to neuronal death. Following ischemic insult, arginine vasopressin (AVP) can induce edema and L-serine released by astrocytes supports the survival of neuronal cells. The purpose of this study was to examine whether AVP contributed ...
Li Yaohua Y Department of Neurology, West China Hospital, Sichuan University, No. 37 Wainan Guoxue Road, Chengdu, 610041, Sichuan, - - 2014
Hypoxia-inducible factor-1α (HIF-1α) is thought to mediate pharmacoresistance in tumor by inducing Pgp overexpression. We aimed to investigate the expression of HIF-1α and MDR1/P-glycoprotein in refractory epilepsy, to explore the correlation of HIF-1α with epilepsy multidrug resistance. We collected hippocampus and mesial temporal lobe (MTL) cortex of refractory mesial temporal ...
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