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Tatomer Deirdre C DC a Department of Biology , University of North Carolina , Chapel Hill , - - 2014
ABSTRACT The scaffolding protein Symplekin is part of multiple complexes involved in generating and modifying the 3' end of mRNAs, including cleavage-polyadenylation, histone pre-mRNA processing and cytoplasmic polyadenylation. To study these functions in vivo, we examined the localization of Symplekin during development and generated mutations of the Drosophila Symplekin gene. ...
Ding Zufeng Z Little Rock, United States ; - - 2014
Aims: This study was designed to investigate a possible link between hemodynamic shear stress, ROS generation and PCSK9 expression, which determine arterial lipid deposition. Results: Using a parallel-plate flow chamber, we observed that PCSK9 expression in vascular smooth muscle cells (SMCs) and endothelial cells (ECs) reached maximal value at 3-6 ...
Kovac Stjepana S UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, - - 2014
Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECH associated protein 1 (Keap1) thereby providing inducible antioxidant defence. Antioxidant properties of Nrf2 are thought to be mainly exerted by stimulating transcription of antioxidant proteins, whereas ...
Weis Sebastian S Division of Gastroenterology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University Hospital Leipzig, Germany. Electronic address: - - 2014
The gene p8 encodes for a small cytoprotective protein with no apparent enzymatic activity being proposed to act as co-transcription factor whose expression is increased during inflammation. Recent data from astrocytes demonstrates that p8 suppression leads to induction of heme oxygenase 1 (HO-1). Here, we assessed the cross-talk between p8 ...
Maziero R R D RR São Paulo State University, Botucatu, São Paulo, - - 2014
Studies have suggested that the prematuration with meiotic blockers can improve oocyte quality promoting embryonic development; however, its exact effects on cytoplasmic characteristics remain unclear. Thus, this study aimed to evaluate the effects of meiosis block of bovine oocytes with the CDK inhibitors roscovitine (ROS) and butyrolactone (BL-I) on nuclear ...
Cao Dedong D Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. - - 2014
Peroxisome proliferator‑activated receptor-γ coactivator-1α (PGC-1α) is a key regulator of reactive oxygen species (ROS). However, whether it has the same role in multiple myeloma (MM), especially after treatement with chemotherapy, remains unclear. After treating cells with bortezomib or dexamethasone, the expression of PGC-1α, superoxide dismutase 2 (SOD-2) and catalase (CAT) was examined by RT-PCR. PGC-1α ...
Steen Samantha O SO From the Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; Department of Dermatology, Bispebjerg Hospital, and the Department of Rheumatology, Rigshospitalet, University of Copenhagen, Copenhagen; Department of Clinical Genetics, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense; Research Unit of Human Genetics, and Clinical Biochemistry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. Supported by the Foundation for the Advancement of Medical Research, Bang's Foundation, and the Danish Rheumatism Association (R99-A1937). S.O. Steen, MSc; A.L. Carlsen, PhD, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; L.V. Iversen, MD, PhD, Department of Dermatology, Bispebjerg Hospital, University of Copenhagen; M. Burton, PhD, Department of Clinical Genetics, Odense University Hospital, and the Institute of Clinical Research, Research Unit of Human Genetics, University of Southern Denmark; C.T. Nielsen, MD, PhD; S. Jacobsen, MD, DMedSc, Department of Rheumatology, Rigshospitalet, University of Copenhagen; N.H.H. Heegaard, MD, DMedSc, DNatSc, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, and the Institute of Clinical Research, Clinical Biochemistry, University of Southern Denmark. Address correspondence to Dr. N. Heegaard, Department of Autoimmunology and Biomarkers, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. E-mail: nhe@ssi.dk. Accepted for publication October 1, - - 2014
To evaluate the expression profile of cell-free circulating microRNA (miRNA) in systemic sclerosis (SSc), healthy controls (HC), and systemic lupus erythematosus (SLE). Total RNA was purified from plasma and 45 different, mature miRNA were measured using quantitative PCR assays after reverse transcription. Samples (n = 189) were from patients with ...
Ghane Zadeh Faezeh F Division of Genomics, Systems Biology Institute, Chemical Injury Research Center, Baqiyatallah University of Medical Sciences , Tehran , Iran - - 2014
Abstract Sulfur mustard (SM) is a blister-forming agent and can cause damages in various momentous human organs. Previous studies have demonstrated that chemical and mechanical injuries of epithelial cells cause to give rise the secretion of TGF-β1 and TGF-β2. These cytokines play a key role in respiratory remodeling due to ...
Hamid Fursham M FM School of Biological Sciences, Nanyang Technological University, - - 2014
Alternative splicing (AS) provides a potent mechanism for increasing protein diversity and modulating gene expression levels. How alternate splice sites are selected by the splicing machinery and how AS is integrated into gene regulation networks remain important questions of eukaryotic biology. Here we report that polypyrimidine tract-binding protein 1 (Ptbp1/PTB/hnRNP-I) ...
Wierda Rutger J RJ Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The - - 2014
Alterations in epigenetic processes are frequently noted in human disease. These epigenetic processes involve methylation of DNA and post-translational modifications of histones. It is well established that in particular histone methylation plays a key role in gene transcription. In this study, we have investigated the relationship between triple methylation of ...
Qiu Li-Juan LJ Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of - - 2014
The aim of this study was to investigate the mRNA expression levels of suppressor of cytokine signaling 1 (SOCS1) in patients with systemic lupus erythematosus (SLE) compared with healthy controls. The associations of systemic lupus erythematosus disease activity index scores and clinical features of SLE with the expression levels of ...
Dai Lei L Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8523, - - 2014
Histone acetylation is involved in the regulation of chromatin structure and gene function. We reported previously that histone H3 acetylation pattern is subject to dynamic changes and limited to certain stages of germ cell differentiation during murine spermatogenesis, suggesting a crucial role for acetylation in the process. In the present ...
Cai X Z XZ Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang, - - 2014
The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. ...
Cai X Z XZ Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang, - - 2015
The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. ...
Chen Yi-Hui YH National Defense Medical Center, Graduate Institute of Aerospace and Undersea Medicine, Neihu, Taipei, Taiwan ; - - 2014
Epigenetic asymmetry has been shown to be associated with the first lineage allocation event in preimplantation development, i.e., the formation of the trophectoderm (TE) and inner cell mass (ICM) lineages in the blastocyst. Because parthenogenesis causes aberrant segregation between the TE and ICM lineages, we examined several development-associated histone modifications ...
Koretsi Vasiliki V Department of Orthodontics, University Medical Centre Regensburg, - - 2014
Summary BACKGROUND/OBJECTIVE : Chondrogenesis is an integral part of endochondral bone formation, by which the midline cranial base is developed. Reactive oxygen species (ROS) are required in chondrogenic differentiation and antioxidant enzymes regulate their levels. The aim of this study was to localize the antioxidant enzyme glutathione peroxidase 1 (Gpx1) ...
Shi Ning N Department of Physiology & Pharmacology, University of Georgia, Athens, GA - - 2014
Transforming growth factor-β (TGF-β) plays an important role in smooth muscle (SM) differentiation, but the downstream target genes regulating the differentiation process remain largely unknown. In this study, we identified Olfactomedin 2 (Olfm2) as a novel regulator mediating SM differentiation. Olfm2 was induced during TGF-β-induced SM differentiation of human embryonic ...
Giulietti M M Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, Ancona, Italy, - - 2014
Regulation of nuclear mRNA export or retention is carried out by RNA elements but the mechanism is not yet well understood. To understand the mRNA export process, it is important to collect all the involved RNA elements and their trans-acting factors. By hand-curated literature screening we collected, in ExportAid database, ...
Jin Xiaoting X Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan, 030006, - - 2014
p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), the major isomer of persistent 1,1-Bis(4-chlorophenyl)-2,2,2-trichloroethane metabolite, is highly associated with the risk of liver cancer. γ-glutamyl-cysteine synthetase (γ-GCS), which is the rate-limiting enzyme of glutathione (GSH) biosynthesis and an important scavenger of reactive oxygen species (ROS), is considered as a potential therapeutic target for many cancers. However, ...
Lashine Ya Y The Molecular Pathology Research Group, the German University in Cairo, Cairo, - - 2014
MicroRNA-155 is involved in immune cell, differentiation, maturation and function. MiR-155 showed variable dysregulated expression in autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients. MiR-155 was previously confirmed to directly target CAMP response element binding protein (CREB), which was previously identified as a positive regulator ...
Li Liangde L Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Laboratory of Insect Toxicology, South China Agricultural University, Guangzhou, Guangdong 510642, PR China. Electronic address: - - 2014
Mitochondrial complex I is the main source of reactive oxygen species (ROS) production, but the exact site of superoxide generation or their relative contribution is not clear. This study aims to determine the function of iron-sulfur clusters (ISCU) in the initiation of ROS generation. ISCU2 and ISCU8 were cloned from ...
Stasevich Timothy J TJ 1] Graduate School of Frontier Biosciences, Osaka University, Osaka, 565-0871, Japan [2] Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523-1870, USA [3] Transcription Imaging Consortium, Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, - - 2014
In eukaryotic cells, post-translational histone modifications have an important role in gene regulation. Starting with early work on histone acetylation, a variety of residue-specific modifications have now been linked to RNA polymerase II (RNAP2) activity, but it remains unclear if these markers are active regulators of transcription or just passive ...
Lee Moon-Sing MS Department of Radiation Oncology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan; School of Medicine, Tzu Chi University, Hualien, - - 2014
Alternative splicing of pre-mRNA, catalyzed by small nuclear ribonucleoproteins (snRNPs), plays an important role in proteome complexity and the modulation of cellular functions. Small nuclear ribonucleoprotein polypeptide N, SmN, is tissue-specifically expressed, where it replaces SmB/B' in the Sm core assembly of snRNPs. Recent studies have demonstrated that perturbation of ...
Kanzaki Hiroyuki H Tohoku University Hospital, Maxillo-Oral Disorders; Department of orthodontics, School of Dental Medicine, Tsurumi University. Electronic address: - - 2014
It has been reported that reactive oxygen species (ROS) play a role as intracellular signaling molecules in RANKL stimulation. Previously we demonstrated that induction of cytoprotective enzyme expression by Nrf2-gene transfer successfully ameliorated RANKL-dependent osteoclastogenesis. In the present study, we hypothesized that Nrf2 activation by inhibiting ubiquitination and degradation of ...
Kim Sung Gyun SG 0000-0002-5034-0527 Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea. ; Department of Immunology, Seoul National University Postgraduate School, Seoul, - - 2014
The expression of hypoxia-inducible factor (HIF) is influenced by reactive oxygen species (ROS). Effect of bilirubin on HIF-1 expression in proximal tubular cells was investigated under physiological oxygen concentration, which is relative hypoxic condition mimicking oxygen content in the medulla of renal tissue. The human kidney (HK2) cells were cultured ...
Sasaki Mina M Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka 8140193, Japan; Department of Oral and Maxillofacial Surgery, Fukuoka Dental College, Fukuoka 8140193, - - 2014
Reactive oxygen species (ROS) can cause severe damage to DNA, proteins and lipids in normal cells, contributing to carcinogenesis and various pathological conditions. While cellular senescence arrests the early phase of cell cycle without any detectable telomere loss or dysfunction. ROS is reported to contribute to induction of cellular senescence, ...
Lu Ming-Chi MC Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, School of Medicine, Tzu Chi University, Hualien, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Department of Biomedical Sciences, Chang Gung University, Taoyuan and Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Chiayi, Taiwan. Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, School of Medicine, Tzu Chi University, Hualien, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Department of Biomedical Sciences, Chang Gung University, Taoyuan and Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Chiayi, - - 2014
The aim of this study was to investigate the pathogenic role of calcium (Ca(2+)) influx-regulated microRNAs (miRNAs) in T cells from patients with SLE. Expression profiles of 270 human miRNAs in Jurkat cells co-cultured with or without ionomycin were analysed by real-time PCR. Differential expression of miRNAs in T cell ...
Wang Xin X Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: - - 2014
Obesity has become a worldwide public health problem, which is mainly determined by excess energy intake and adipose tissue expansion. Adipose tissue expansion can occur through hyperplasia (adipocyte differentiation) or hypertrophy. Retinoic acid was shown to inhibit adipocyte differentiation. However, the molecular mechanism is unclear. In the study, we found ...
Sato Shuzo S Division of Rheumatology and Immunology, Department of Medicine. Medical University of South Carolina, Charleston, SC, 29425, - - 2014
Objective. The Fli-1 transcription factor is implicated in the pathogenesis of systemic lupus erythematosus (SLE) in both human patients and animal models. Dysregulation of interleukin 6 (IL-6) is also associated with SLE. We investigated whether Fli-1 directly regulates the expression of IL-6. Methods. Sera were collected from wild-type and Fli-1 ...
Fatemi Nayeralsadat N Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, P.O. Box: 19395-4644, Tehran, - - 2014
Reactive oxygen species (ROS) and oxidative stress is one of the main reasons of male infertility. MicroRNAs (miRNAs) regulate multiple intracellular processes. Alterations in miRNAs expression may occur in different conditions and diseases. In this study, the effect of oxidative stress induced by tertiary-butyl hydroperoxide (TBHP) on the expression of ...
Tang Wenhao W Department of Urology, Peking University Third Hospital, Beijing, People's Republic of China; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, People's Republic of - - 2014
To study the effect of freezing techniques and to optimize a method for trace amounts of testicular spermatozoa from biopsed seminiferous tubules. The level of reactive oxygen species (ROS) and the gene expression of heme oxygenase-1 was evaluated. Prospective experimental study. University-based laboratory. Eighteen adults with male fator infertility underwent ...
Wen Duancheng D Department of Genetic Medicine, Ansary Stem Cell Institute, Howard Hughes Medical Institute, Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Genomics Resources Core Facility, and Department of Physiology, Weill Cornell Medical College, New York, NY - - 2014
Mature oocyte cytoplasm can reprogram somatic cell nuclei to the pluripotent state through a series of sequential events including protein exchange between the donor nucleus and ooplasm, chromatin remodeling, and pluripotency gene reactivation. Maternal factors that are responsible for this reprogramming process remain largely unidentified. Here, we demonstrate that knockdown ...
Yeh Po-Yen PY Department of Neurology, Saint Martin De Porres Hospital, Chiayi, Taiwan, - - 2014
Protein glutathionylation is a protective mechanism that functions in response to mild oxidative stress. Carbon monoxide (CO) can increase the ROS concentration from a low level via the inhibition of cytochrome c oxidase. We therefore hypothesized that CO would induce NF-κB-p65 glutathionylation and then show anti-inflammatory effects. In our present ...
Heng Boon Chin BC Department of Biosystems Science and Engineering (D-BSSE), ETH Zurich, Mattenstrasse 26, CH-4058 Basel, - - 2014
Previous studies reported much heterogeneity in baseline neural marker expression by undifferentiated mesenchymal stem cells (MSCs) of animal and human origin, which could confound reproducibility of neural differentiation experiments with MSCs. Nevertheless, basic donor characteristics such as age and gender were unspecified in these previous studies; and relative levels of ...
Porter Keith M KM Department of Pathology, Cambridge Institute of Medical Research, University of Cambridge, Wellcome Trust / MRC Building, Hills Road, Cambridge, CB2 0XY, - - 2014
The tapasin-related protein TAPBPR is a novel component of the antigen processing and presentation pathway, which binds to MHC class I coupled with β2m. Here we describe six alternatively spliced TAPBPR transcripts from the TAPBPL gene and investigate three of these at a protein level. TAPBPR transcripts lacking exon 5, ...
Buzby Jeffrey S JS Hematology Research Laboratory, 510 Research Institute, CHOC Children's Hospital of Orange County, 1201 W. La Veta Avenue, Orange, CA, 92868, USA, - - 2014
Variable tissue factor (TF) expression by human microvascular endothelial cells (HMVEC) may be regulated by two promoter haplotypes, distinguished by an 18-basepair deletion (D) or insertion (I) at -1,208. We sought to determine the relationship between these haplotypes and interleukin-1α (IL-1α)-induced TF expression in neonatal versus adult HMVEC. IL-1-stimulated TF ...
Han Kyung Ah KA Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, - - 2014
Regulator of calcineurin 1 (RCAN1; also referred as DSCR1 or MCIP1) is located in close proximity to a Down syndrome critical region of human chromosome 21. Although RCAN1 is an endogenous inhibitor of calcineurin signaling that controls lymphocyte activation, apoptosis, heart development, skeletal muscle differentiation, and cardiac function, it is ...
Gao Hongjuan H Center for Vascular and Inflammatory Diseases and the Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, United States of - - 2014
Mitochondrial reactive oxygen species (ROS) regulate a variety of biological processes by networking with signal transduction pathways to maintain homeostasis and support adaptation to stress. In this capacity, ROS have been shown to promote the differentiation of progenitor cells, including mammalian embryonic and hematopoietic stem cells and Drosophila hematopoietic progenitors ...
Im Nam-Kyung NK College of Pharmacy, Keimyung University, Dae-gu 704-701, Republic of - - 2014
This study was carried out to investigate the effect of Spatholobus suberectus Dunn (SS) on the protection of chondral defect and inhibition of osteoclastogenesis. To examine these effects, we measured the matrix metalloproteinase (MMP) levels in SW1353 chondrosarcoma cells and performed tartrate-resistant acid phosphatase (TRAP) staining in bone marrow macrophage ...
Baldelli S S Scientific Institute for Research, Hospitalization and Health Care, Università Telematica San Raffaele Roma, Via di Val Cannuta 247, Rome, - - 2014
Mitochondrial biogenesis and mitophagy are recognized as critical processes underlying mitochondrial homeostasis. However, the molecular pathway(s) coordinating the balance between these cellular programs is still poorly investigated. Here, we show an induction of the nuclear and mitochondrial peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) during myogenesis, which in turn ...
Szczepanek-Parulska Ewelina E Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznań, - - 2013
PAX8 gene encodes one of the transcription factors engaged in the regulation of proper development of thyroid gland as well as Müllerian and renal/upper urinary tracts. So far, six alternatively spliced transcripts were reported, however, sequences of only four were deposited in the NCBI database. Here, we evaluate a fragment ...
Andrukhov Oleh - - 2013
Abstract Objective. Gingival fibroblasts (GFs) produce pro-inflammatory cytokines in response to stimulation with lipopolysaccharide (LPS) of Porphyromonas gingivalis, which is thought to be mediated by activation of toll-like receptors (TLR)2 and TLR4. The present study investigated the expression of interleukin (IL)-6, TLR2, and TLR4 in GFs of seven different donors ...
Blice-Baum Anna C - - 2014
Fragile X syndrome, the most common form of inherited mental impairment in humans, is caused by the absence of the fragile X mental retardation protein (FMRP) due to a CGG trinucleotide repeat expansion in the 5'-untranslated region (UTR) and subsequent translational silencing of the fragile x mental retardation-1 (FMR1) gene. ...
Kuster Diederik W D - - 2013
Hypertrophic cardiomyopathy (HCM) is predominantly caused by mutations in genes encoding sarcomeric proteins. One of the most frequent affected genes is MYBPC3, which encodes the thick filament protein cardiac myosin binding protein C. Despite the prevalence of HCM, disease pathology and clinical outcome of sarcomeric mutations are largely unknown. We ...
Davidson Lee - - 2013
Splicing of human pre-mRNA is reciprocally coupled to 3' end formation by terminal exon definition, which occurs co-transcriptionally. It is required for the final maturation of most human pre-mRNAs and is therefore important to understand. We have used several strategies to block splicing at specific stages in vivo and studied ...
Takizawa Yusuke - - 2013
Nitric oxide (NO) donors increase the permeability of water-soluble compounds with neither loss of cell viability nor lactate dehydrogenase release, but the involved mechanism is not fully understood. In this study, we focused on permeation via the transcellular route and P-glycoprotein, which is a typical ABC transporter. We examined the ...
Tippett Emma E Centre for Virology, The Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia. - - 2013
Tetraspanins are a family of membrane-organizing proteins that mediate diverse functions. Little is known of their expression or function in myeloid cells. Here, expression of CD9, CD53, CD63, and CD81, tetraspanins that have been implicated in HIV-1 pathogenesis, were characterized in normal monocyte subsets, in MDM, and in HIV-1-infected donors. ...
Belleannée Clémence - - 2013
STUDY QUESTION: Does vasectomy impact microRNA (miRNA) expression in the epididymis and seminal microvesicles (SMVs) in a non-reversible manner? SUMMARY ANSWER: The miRNA signature in the epididymis and SMVs is altered by vasectomy and only partially restored after vasovasostomy surgery. WHAT IS KNOWN ALREADY: Vasectomy modifies the epididymal transcriptome and ...
Mauskar Neil A - - 2013
Understanding the physiology of donor site healing will lead to advances in how these wounds are treated and may ultimately allow faster healing, more frequent autografting, and more effective care of the burn-injured patient. Unfortunately, a paucity of data exists regarding perfusion metrics over the course of donor site healing. ...
Chaiwongkot Arkom - - 2013
HPV 58 is detected commonly in cervical cancer in East Asian countries. To evaluate the HPV 58 physical state, the amplification of papillomavirus oncogene transcripts (APOT) and hybridisation assays were established. Episome- and integrate-derived transcripts were confirmed by direct sequencing. Twenty-nine HPV 58 positive samples from various cervical lesions were ...
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