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Fiskus W W Houston Methodist Research Institute, Houston, - - 2014
The canonical WNT-β-catenin pathway is essential for self-renewal, growth and survival of AML stem/blast progenitor cells (BPCs). Deregulated WNT signaling inhibits degradation of β-catenin, causing increased nuclear translocation and co-factor activity of β-catenin with the transcriptional regulator TCF4/LEF1 in AML BPCs. Here, we determined the pre-clinical anti-AML activity of the ...
Xiao Nan N Division of Hematology-Oncology, University of Massachusetts Medical School, Worcester, MA, United - - 2014
Thrombopoietin (Thpo) signaling through the c-Mpl receptor promotes either quiescence or proliferation of hematopoietic stem cells (HSCs) in a concentration-dependent manner, however, in vivo Thpo serum levels are responsive to platelet mass rather than HSC demands suggesting additional regulation exists. Ott1 (Rbm15), a spliceosomal component originally identified as a fusion ...
Fuhrmann Dominik C DC Institute of Biochemistry I/ZAFES, Goethe-University Frankfurt, 60590 Frankfurt, - - 2014
Macrophages play important roles in many diseases and are frequently found in hypoxic areas. A chronic hypoxic microenvironment alters global cellular protein expression but molecular details remain poorly understood. Although hypoxia inducible factor (HIF) is an established transcription factor allowing adaption to acute hypoxia, responses to chronic hypoxia are more ...
Zhang Yao Y Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University, Donghu Road 169, Wuhan 430071, China; Department of Biochemistry & Molecular Biology, Wannan Medical College, Wuhu 241000, - - 2014
Acute promyelocytic leukemia (APL) is largely caused by the t(15,17) chromosome translocation, leading to the production of the PML/retinoic acid receptor alpha fusion. All-trans retinoic acid (ATRA) and arsenic trioxide (ATO), as a monotherapy or combination therapy, have been successfully used to treat APL primarily by targeting the degradation of ...
Zhou Jing-Dong JD Department of Hematology, Affiliated People's Hospital of Jiangsu University, 8 Dianli Rd., Zhenjiang, 212002, People's Republic of - - 2015
To investigate the expression of brain and acute leukemia, cytoplasmic (BAALC) and analyze its clinical significance in Chinese de novo acute myeloid leukemia (AML). Real-time quantitative PCR (RQ-PCR) was carried out to detect BAALC transcript level in 121 de novo AML patients and 41 normal controls. BAALC transcript level in ...
Chuang M-K MK Department of Laboratory Medicine, National Taiwan University - - 2014
As a highly heterogeneous disease, acute myeloid leukemia (AML) needs fine risk stratification to get an optimal outcome of patients. MicroRNAs have florid biological functions and play critical roles in the pathogenesis and prognosis in AML. Expression levels of some single microRNAs are influential for prognosis, but a system integrating ...
Hecht Anna - - 2014
Abstract Wilms' Tumor 1 (WT1) is known to be highly expressed in acute promyelocytic leukemia (APL) but information on its impact on prognosis is lacking. WT1 expression was analyzed in bone marrow samples of 79 APL patients at initial diagnosis. Patients had a differing outcome according to their level of ...
Antosz Halina H Department of Clinical Genetics, Medical University of Lublin, Lublin, Poland. Electronic address: - - 2014
Chronic lymphocytic leukemia is characterized by the accumulation of functionally abnormal, monoclonal B lymphocytes in the peripheral blood, bone marrow, lymph nodes and spleen, resulting in a reduction count of normal immunocompetent cells and their impaired immune function. The defect in transmission of signals from various types of extracellular receptors, ...
Hwang Yong-Woo YW Department of Life Sciences, Korea University, Seoul 136-701, Republic of - - 2014
RNA leukemia viruses induce T-cell lymphoblastic lymphomas or myeloid leukemias. Infection of cells with Moloney murine leukemia virus (M-MuLV) up-regulates the expression of a number of cellular genes, including those involved in T-lymphocyte activation. Previously, we demonstrated that this up-regulation occurs via the trans-activation activity of the M-MuLV long terminal ...
Nemes Karolina K 2nd Department of Pediatrics, Semmelweis University, Budapest, 1094, Tűzoltó u. 7-9., - - 2014
In spite of the improved efficacy of therapy, it still fails in 15-20 % of childhood acute lymphoblastic leukemia (ALL) patients. Recently, altered expression of certain miRNAs (miRs) have been described in ALL with potential effect on prognosis. Presence of certain miRs (miRNA-16, -21, -24, -29b, -128b, -142-3p, -155, -223) was ...
Ma Yu - - 2014
BackgroundKnowledge of the oncogenic signaling pathways of T-cell acute lymphoblastic leukemia (T-ALL) remains limited. Constitutive aberrant activation of the nuclear factor kappa B (NF-¿B) signaling pathway has been detected in various lymphoid malignancies and plays a key role in the development of these carcinomas. The zinc finger-containing protein, A20, is ...
Gordon T T Department of Neuroscience, University of Alberta, Edmonton, AB, T6G 2S2; ICORD (International Collaboration on Repair Discoveries); Department Zoology, University of British Columbia, Vancouver, BC; Department Surgery, University of British Columbia, Vancouver, BC. Electronic address: - - 2014
Chronically axotomized motoneurons progressively fail to regenerate their axons. Since axonal regeneration is associated with the increased expression of tubulin, actin and GAP-43, we examined whether the regenerative failure is due to failure of chronically axotomized motoneurons to express and sustain the expression of these regeneration associated genes (RAGs). Chronically ...
Yashiro-Ohtani Yumi Y Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, - - 2014
Notch is needed for T-cell development and is a common oncogenic driver in T-cell acute lymphoblastic leukemia. The protooncogene c-Myc (Myc) is a critical target of Notch in normal and malignant pre-T cells, but how Notch regulates Myc is unknown. Here, we identify a distal enhancer located >1 Mb 3' ...
Kaeda Jaspal - - 2014
ABSTRACT A better understanding of events triggering chronic myeloid leukemia progression are critical to optimised clinical management of chronic myeloid leukemia (CML). We sought to validate that increased Musashi 2 (MSI2), a post transcription regulator, expression is associated with progression and prognosis. Screening of 152 CML patients showed MSI2 was ...
Willer A A 1] The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark [2] Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark [3] Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, - - 2014
Members of the TALE (Three-amino acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage leukemia (MLL) gene. A well-characterized member of this protein family is MEIS1, which orchestrates a transcriptional program required for the maintenance of MLL-rearranged acute ...
An Cui - - 2014
Abstract Deregulation of secreted frizzled-related protein 1 (SFRP1) has been found in many types of cancers. However, it is still rarely known about the pattern of SFRP1 expression in acute myeloid leukemia (AML). This study detected SFRP1 expression in AML patients. SFRP1 expression remarkably decreased in AML patients compared to ...
Zou Zhi-Jian ZJ Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China. Department of Hematology, Wuxi People Hospital Affiliated of Nanjing Medical University, Wuxi, - - 2014
We previous found the expression level of PTEN was low in the chronic lymphocytic leukemia (CLL) patients. To assess the pathogenic contribution of the low expression of PTEN, we determined PTEN-regulating miRNA interference, PTEN promoter methylation and PTEN gene mutation condition in CLL. One hundred and fifty-four previously untreated CLL ...
Jing Duohui D Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, - - 2014
Glucocorticoids are critical components of combination chemotherapy regimens in pediatric acute lymphoblastic leukemia (ALL). The pro-apoptotic BIM protein is an important mediator of glucocorticoid-induced apoptosis in normal and malignant lymphocytes, while the anti-apoptotic BCL2 confers resistance. The signaling pathways regulating BIM and BCL2 expression in glucocorticoid-treated lymphoid cells remain unclear. ...
Li Xiangyang X 1 Department of Pharmacy, Qinghai University Medical College , Xining, China - - 2014
Abstract Xiangyang, Li, Xuejun Wang, Yongping Li, Junbo Zhu, Xiaodong Su, Xingchen Yao, Xueru Fan, and Yabin Duan. The activity, protein, and mRNA expression of CYP2E1 and CYP3A1 in rats after exposure to acute and chronic high altitude hypoxia. High Alt Med Biol 15:000-000, 2014.-The effects of exposure to acute ...
Shah N M NM 1] Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, UK [2] Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, - - 2014
Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML). Posttranscriptional regulation by microRNAs (miRNAs) can affect the malignant phenotype of AML cells. In this study, we identified and characterised NRF2-regulated miRNAs in AML. ...
Raz Shachar S The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion-Israel Institute of Technology, Haifa, - - 2014
Polyglutamylation of antifolates catalyzed by folylpoly-γ-glutamate synthetase (FPGS) is essential for their intracellular retention and cytotoxic activity. Hence, loss of FPGS expression and/or function results in lack of antifolate polyglutamylation and drug resistance. Members of the TGF-β/Smad signaling pathway are negative regulators of hematopoiesis and deregulation of this pathway is ...
Zhang Bing B Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. - - 2014
Forkhead box M1 (FOXM1) is a typical proliferation‑associated transcription factor, which is overexpressed in many types of human cancer. We investigated the expression level of FOXM1 in patients with untreated acute leukemia (AL) and explored the correlation between expression levels and AL type. The relationship between the expression of the genes ...
Yao Jie - - 2014
HOXA10, a homeobox-containing gene involved in definitive hematopoiesis, which implicated in the pathogenesis of acute myeloid leukemia, has been studied extensively. But the regulatory mechanism that drives HOXA10 expression is still unclear. In this paper, HOXA10 regulated by MLL1 with an epigenetic way has been demonstrated. The HOXA10 promoter contains ...
Tao Yan-Fang YF Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, Jiangsu, P.R. - - 2014
Acute myeloid leukemia (AML) is the second-most common form of leukemia in children. Aberrant DNA methylation patterns are characteristic of AML. Zinc finger protein 382 (ZNF382) has been suggested to be a tumor suppressor gene possibly regulated by promoter hypermethylation in various types of human cancer. However, ZNF382 expression and methylation ...
Chen Ying-Jung YJ Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, - - 2014
The aim of the present study was to explore the signaling pathways associated with the effect of simvastatin on matrix metalloproteinase-2 (MMP-2)/MMP-9 expression in human leukemia K562 cells. In sharp contrast to its insignificant effect on MMP-2, simvastatin down-regulated MMP-9 protein expression and mRNA levels in K562 cells. Simvastatin-induced Pin1 ...
Kim Myungshin M Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, - - 2014
We investigated the correlation between FLT3 expression and IL10 gene promoter polymorphism in acute myeloid leukemia with RUNX1-RUNX1T1 and their clinical significance. FLT3 mRNA expression was measured by real-time quantitative PCR (qPCR) and immunohistochemical staining (IHC) on bone marrow (BM) leukemic cells. IL10 gene promoter polymorphisms including rs1800896 (G-1082A), rs1800871 ...
Sakata Hiroyuki H Graduate School of Science and Technology, Niigata University, 8050 Ikarashi-2, Nishi-ku, Niigata, 950-2181, - - 2014
We have shown previously that two populations of myeloid cells emerge in the anterior and posterior ventral blood islands (aVBI and pVBI) at the different stages in Xenopus laevis embryo. In order to elucidate the regulatory mechanism of myeloid cell differentiation in the aVBI, we examined the role of Nkx2.5, ...
Hughes James M - - 2014
CCAAT/enhancer-binding protein-¿ (CEBPA) is a critical regulator of myeloid differentiation. Disruption of CEBPA function contributes to the development of acute myeloid leukemia (AML). CEBPA regulates a large number of protein coding genes of which several were shown to contribute to CEBPA function. In this study, we expand the analysis of ...
Xu Xuefen X State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People's Republic of - - 2014
Constitutive NF-E2-related factor 2(Nrf2) activation has been recently reported to play a pivotal role in enhancing cell survival and resistance to anticancer drugs in many tumors. Previously, much effort has been devoted to the investigation of blocking Nrf2 function in cultured cells and cancer tissues, but few research has been ...
Fukuno Kenji - - 2014
Abstract The immunomodulatory effects of indoleamine 2,3-dioxygenase (IDO) are ascribed to its ability to catalyze breakdown of the essential amino acid L-tryptophan. We applied reverse transcription PCR (RT-PCR) to examine IDO mRNA expression in AML blasts, and investigated its clinical significance. We enrolled 62 patients with AML between April 2005 ...
Zeng Chengwu - - 2014
Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17), which fuses PML with retinoic acid receptor alpha (RARalpha). Although PML-RARalpha is crucially important for pathogenesis and responsiveness to treatment, the molecular and cellular mechanisms by which PML-RARalpha exerts its oncogenic potential have not been fully elucidated. Recent reports ...
Li June J Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, TX - - 2014
Transcriptional mechanisms governing hematopoietic stem cell (HSC) quiescence, self-renewal, and differentiation are not fully understood. Sequence-specific ssDNA-binding protein 2 (SSBP2) is a candidate acute myelogenous leukemia (AML) suppressor gene located at chromosome 5q14. SSBP2 binds the transcriptional adaptor protein Lim domain-binding protein 1 (LDB1) and enhances LDB1 stability to regulate ...
Kato T T 1] Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan [2] Life Science center of Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, - - 2014
In leukemogenesis, Notch signaling can be up- and down-regulated in a context-dependent manner. The transcription factor hairy and enhancer of split-1 (Hes1) is well characterized as a downstream target of Notch signaling. Hes1 encodes a basic helix-loop-helix-type protein, and represses target gene expression. Here we report that deletion of the ...
Xishan Z Z Clinical Research Center, Affiliated Hospital of Guangdong Medical College, Guangdong province, - - 2014
The aim of this study was to investigate the role and mechanism of miR-23a in the regulation of BCR/ABL and to provide a new prognostic biomarker for chronic myeloid leukemia (CML). The expression levels of miR-23a and BCR/ABL were assessed in 42 newly diagnosed CML patients, 37 CML patients in ...
Scopim-Ribeiro Renata R Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, São Paulo, - - 2014
TET2, a member of the ten-eleven-translocation (TET) family genes that modify DNA by converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), is located in chromosome 4q24, and is frequently mutated in myeloid malignancies. The impact of TET2 mutation on survival outcomes is still controversial, however functional studies have proved that it is ...
Herranz Daniel D Institute for Cancer Genetics, Columbia University, New York, New York, - - 2014
Efforts to identify and annotate cancer driver genetic lesions have been focused primarily on the analysis of protein-coding genes; however, most genetic abnormalities found in human cancer are located in intergenic regions. Here we identify a new long range-acting MYC enhancer controlled by NOTCH1 that is targeted by recurrent chromosomal ...
Kuo Yuan-Yeh YY National Taiwan University; - - 2014
CXC chemokine receptor 4 (CXCR4) is an essential regulator for homing, and maintenance of hematopoietic stem cells within the bone marrow niches. In the analyses of clinical implications of bone marrow CXCR4 expression in patients with acute myeloid leukemia, we not only found higher CXCR4 expression was an independent poor ...
Lucas Claire M CM Univesity of Liverpool - - 2014
ALOX5 is implicated in chronic myeloid leukaemia development in mouse leukaemic stem cells, but its importance in human chronic myeloid leukaemia is unknown. Functional ALOX5 was assessed using an LTB4 ELISA and ALOX5 and LTB4R1 mRNA expression was determined via a TaqMan gene expression assay. LTB4R1 and 5-LOX protein levels ...
van Riel Boet - - 2014
Abstract Purine-rich box1 (PU.1) is a transcription factor that not only has a key role in the development of most hematopoietic cell lineages but also in the suppression of leukemia. To exert these functions, PU.1 can cross-talk with multiple different proteins by forming complexes in order to activate or repress ...
Skorvaga M - - 2014
The precise diagnosis of acute lymphoblastic leukemia is essential for correct prognosis assessment and therapy regimen selection. At present, immunophenotyping, cytogenetics and molecular screening are major and complementary methods utilized in a routine leukemia diagnostics. The aim of this study was to validate the application of multiplex reverse transcription-polymerase chain reaction ...
Quintás-Cardama Alfonso A Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX. Electronic address: - - 2014
Tripartite motif (TRIM)-62 is a putative tumor suppressor gene whose role in leukemia is unknown. We evaluated the effect of TRIM62 protein expression in patients with acute myeloid leukemia (AML). We used reverse-phase protein array methodology to determine TRIM62 levels in leukemia-enriched protein samples from 511 patients newly diagnosed with ...
Choi Dan-Bee DB Department of Laboratory Medicine, School of Medicine, Wonkwang University, Iksan, Republic of Korea; Center for Metabolic Function Regulation, Institute of Wonkwang Medical Science and Institute of Wonkwang Clinical Medicine, Wonkwang University, Iksan, Republic of - - 2014
We investigated three splicing factor proteins (SFPs; NSRP70, SRSF1, and HNRNPA1) in 187 adults with and without acute leukemia (AL). We showed that NSRP70 is a novel lymphoblastic AL (ALL) surrogate marker, which presented excellent diagnostic accuracy (92%) and disappeared during remission. Its highest molecular weight form, but not total ...
Wei Sixi S Hematopoietic Stem Cell Transplantation Center of Guizhou Province, Department of Hematology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550004, China; Department of Clinical Biochemistry, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550004, - - 2014
There are limited eligible clinical markers at present to monitor the progress of chronic myeloid leukemia (CML). Heme oxygenase-1 (HO-1), as one of the most important oxidation-regulating enzymes in vivo, suggests the onset and progression of cancer when highly expressed. Furthermore, HO-1 level is related with the occurrence and development ...
Zhu Hong H Department of Biomedical Engineering, College of Biology, Hunan University, Changsha, Hunan 410082, P.R. - - 2014
Deregulation of forkhead box (FOX) proteins has been found in many genetic diseases and malignancies including leukemia. Leukemia is a common neoplastic disease of the blood or bone marrow characterized by the presence of immature leukocytes and is one of the leading causes of death due to cancer. Forkhead transcription ...
Taha Masoumeh Fakhr MF Department of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Pajoohesh Boulevard, P.O. Box 14965-161, Tehran 1417863171, - - 2014
The expression pattern of pluripotency markers in adipose tissue-derived stem cells (ADSCs) is a subject of controversy. Moreover, there is no data about the signaling molecules that regulate these markers in ADSCs. In the present study, we studied the roles of leukemia inhibitory factor (LIF) and miR-302 in this regard. ...
Xu Lan L Department of Hematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, - - 2014
Background. Although the curative rate for acute promyelocytic leukemia (APL) has been improved over decades, long-term prognosis is still poor. The genetic pathways that regulated cell lineage fate during the development of APL remain unclear. Methods. We investigated the correlations of miR-146a expression with its target gene Smad4 and the ...
Liu S S Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People's Republic of - - 2014
Trophoblast cell migration and invasion are crucial for the establishment of a successful pregnancy. Protein O-fucosyltransferases, such as poFUT1 and poFUT2, catalyze the O-fucosylation of proteins and have important roles in embryonic development. Leukemia inhibitory factor (LIF) is a critical cytokine in the regulation of embryonic development and implantation. However, ...
Guo Hong H Department of Laboratory Center, The Affiliated People's Hospital of Jiangsu University Zhenjiang 212002, Jiangsu, People's Republic of China ; School of Medical Science and Laboratory Medicine, Jiangsu University Zhenjiang 212002, Jiangsu, People's Republic of - - 2014
Dysregulation of secreted frizzled-related protein 2 (SFRP2) has been found in various cancers. However, it is little known about the pattern of SFRP2 expression in acute myeloid leukemia (AML). This study was aimed to analyze the expression status of SFRP2 gene in AML patients and explore its clinical significance using ...
Niu Chang-Chun CC Department of Clinical Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China ; Department of Clinical Laboratory, The Third People's Hospital of Chongqing, Chongqing 400014, - - 2014
CCN1 plays distinct roles in various tumor types, but little is known regarding the role of CCN1 in leukemia. We analyzed CCN1 protein expression in leukemia cell lines and in AML bone marrow samples. We also evaluated the effects of antibody- or siRNA-mediated inhibition of CCN1 on the growth of ...
Du Yahui Y Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China. - - 2014
Suppressor with morphogenetic effect on genitalia family member (SMG1) belongs to a family of phosphoinositide 3-kinase-related kinases and is the main kinase involved in nonsense-mediated mRNA decay. Recently, SMG1 was suggested as a novel potential tumor suppressor gene, particularly in hypoxic tumors. To investigate the function of SMG1 in acute ...
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