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Jing Duohui D Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, - - 2014
Glucocorticoids are critical components of combination chemotherapy regimens in pediatric acute lymphoblastic leukemia (ALL). The pro-apoptotic BIM protein is an important mediator of glucocorticoid-induced apoptosis in normal and malignant lymphocytes, while the anti-apoptotic BCL2 confers resistance. The signaling pathways regulating BIM and BCL2 expression in glucocorticoid-treated lymphoid cells remain unclear. ...
Li Xiangyang X 1 Department of Pharmacy, Qinghai University Medical College , Xining, China - - 2014
Abstract Xiangyang, Li, Xuejun Wang, Yongping Li, Junbo Zhu, Xiaodong Su, Xingchen Yao, Xueru Fan, and Yabin Duan. The activity, protein, and mRNA expression of CYP2E1 and CYP3A1 in rats after exposure to acute and chronic high altitude hypoxia. High Alt Med Biol 15:000-000, 2014.-The effects of exposure to acute ...
Shah N M NM 1] Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, UK [2] Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, - - 2014
Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML). Posttranscriptional regulation by microRNAs (miRNAs) can affect the malignant phenotype of AML cells. In this study, we identified and characterised NRF2-regulated miRNAs in AML. ...
Zhang Bing B Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. - - 2014
Forkhead box M1 (FOXM1) is a typical proliferation‑associated transcription factor, which is overexpressed in many types of human cancer. We investigated the expression level of FOXM1 in patients with untreated acute leukemia (AL) and explored the correlation between expression levels and AL type. The relationship between the expression of the genes ...
Yao Jie - - 2014
HOXA10, a homeobox-containing gene involved in definitive hematopoiesis, which implicated in the pathogenesis of acute myeloid leukemia, has been studied extensively. But the regulatory mechanism that drives HOXA10 expression is still unclear. In this paper, HOXA10 regulated by MLL1 with an epigenetic way has been demonstrated. The HOXA10 promoter contains ...
Tao Yan-Fang YF Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, Jiangsu, P.R. - - 2014
Acute myeloid leukemia (AML) is the second-most common form of leukemia in children. Aberrant DNA methylation patterns are characteristic of AML. Zinc finger protein 382 (ZNF382) has been suggested to be a tumor suppressor gene possibly regulated by promoter hypermethylation in various types of human cancer. However, ZNF382 expression and methylation ...
Chen Ying-Jung YJ Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, - - 2014
The aim of the present study was to explore the signaling pathways associated with the effect of simvastatin on matrix metalloproteinase-2 (MMP-2)/MMP-9 expression in human leukemia K562 cells. In sharp contrast to its insignificant effect on MMP-2, simvastatin down-regulated MMP-9 protein expression and mRNA levels in K562 cells. Simvastatin-induced Pin1 ...
Kim Myungshin M Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, - - 2014
We investigated the correlation between FLT3 expression and IL10 gene promoter polymorphism in acute myeloid leukemia with RUNX1-RUNX1T1 and their clinical significance. FLT3 mRNA expression was measured by real-time quantitative PCR (qPCR) and immunohistochemical staining (IHC) on bone marrow (BM) leukemic cells. IL10 gene promoter polymorphisms including rs1800896 (G-1082A), rs1800871 ...
Sakata Hiroyuki H Graduate School of Science and Technology, Niigata University, 8050 Ikarashi-2, Nishi-ku, Niigata, 950-2181, - - 2014
We have shown previously that two populations of myeloid cells emerge in the anterior and posterior ventral blood islands (aVBI and pVBI) at the different stages in Xenopus laevis embryo. In order to elucidate the regulatory mechanism of myeloid cell differentiation in the aVBI, we examined the role of Nkx2.5, ...
Hughes James M - - 2014
CCAAT/enhancer-binding protein-¿ (CEBPA) is a critical regulator of myeloid differentiation. Disruption of CEBPA function contributes to the development of acute myeloid leukemia (AML). CEBPA regulates a large number of protein coding genes of which several were shown to contribute to CEBPA function. In this study, we expand the analysis of ...
Xu Xuefen X State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People's Republic of - - 2014
Constitutive NF-E2-related factor 2(Nrf2) activation has been recently reported to play a pivotal role in enhancing cell survival and resistance to anticancer drugs in many tumors. Previously, much effort has been devoted to the investigation of blocking Nrf2 function in cultured cells and cancer tissues, but few research has been ...
Fukuno Kenji - - 2014
Abstract The immunomodulatory effects of indoleamine 2,3-dioxygenase (IDO) are ascribed to its ability to catalyze breakdown of the essential amino acid L-tryptophan. We applied reverse transcription PCR (RT-PCR) to examine IDO mRNA expression in AML blasts, and investigated its clinical significance. We enrolled 62 patients with AML between April 2005 ...
Zeng Chengwu - - 2014
Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17), which fuses PML with retinoic acid receptor alpha (RARalpha). Although PML-RARalpha is crucially important for pathogenesis and responsiveness to treatment, the molecular and cellular mechanisms by which PML-RARalpha exerts its oncogenic potential have not been fully elucidated. Recent reports ...
Li June J Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, TX - - 2014
Transcriptional mechanisms governing hematopoietic stem cell (HSC) quiescence, self-renewal, and differentiation are not fully understood. Sequence-specific ssDNA-binding protein 2 (SSBP2) is a candidate acute myelogenous leukemia (AML) suppressor gene located at chromosome 5q14. SSBP2 binds the transcriptional adaptor protein Lim domain-binding protein 1 (LDB1) and enhances LDB1 stability to regulate ...
Kato T T 1] Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan [2] Life Science center of Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, - - 2014
In leukemogenesis, Notch signaling can be up- and down-regulated in a context-dependent manner. The transcription factor hairy and enhancer of split-1 (Hes1) is well characterized as a downstream target of Notch signaling. Hes1 encodes a basic helix-loop-helix-type protein, and represses target gene expression. Here we report that deletion of the ...
Xishan Z Z Clinical Research Center, Affiliated Hospital of Guangdong Medical College, Guangdong province, - - 2014
The aim of this study was to investigate the role and mechanism of miR-23a in the regulation of BCR/ABL and to provide a new prognostic biomarker for chronic myeloid leukemia (CML). The expression levels of miR-23a and BCR/ABL were assessed in 42 newly diagnosed CML patients, 37 CML patients in ...
Scopim-Ribeiro Renata R Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, São Paulo, - - 2014
TET2, a member of the ten-eleven-translocation (TET) family genes that modify DNA by converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), is located in chromosome 4q24, and is frequently mutated in myeloid malignancies. The impact of TET2 mutation on survival outcomes is still controversial, however functional studies have proved that it is ...
Herranz Daniel D Institute for Cancer Genetics, Columbia University, New York, New York, - - 2014
Efforts to identify and annotate cancer driver genetic lesions have been focused primarily on the analysis of protein-coding genes; however, most genetic abnormalities found in human cancer are located in intergenic regions. Here we identify a new long range-acting MYC enhancer controlled by NOTCH1 that is targeted by recurrent chromosomal ...
Kuo Yuan-Yeh YY National Taiwan University; - - 2014
CXC chemokine receptor 4 (CXCR4) is an essential regulator for homing, and maintenance of hematopoietic stem cells within the bone marrow niches. In the analyses of clinical implications of bone marrow CXCR4 expression in patients with acute myeloid leukemia, we not only found higher CXCR4 expression was an independent poor ...
Lucas Claire M CM Univesity of Liverpool - - 2014
ALOX5 is implicated in chronic myeloid leukaemia development in mouse leukaemic stem cells, but its importance in human chronic myeloid leukaemia is unknown. Functional ALOX5 was assessed using an LTB4 ELISA and ALOX5 and LTB4R1 mRNA expression was determined via a TaqMan gene expression assay. LTB4R1 and 5-LOX protein levels ...
van Riel Boet - - 2014
Abstract Purine-rich box1 (PU.1) is a transcription factor that not only has a key role in the development of most hematopoietic cell lineages but also in the suppression of leukemia. To exert these functions, PU.1 can cross-talk with multiple different proteins by forming complexes in order to activate or repress ...
Raz Shachar S The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion-Israel Institute of Technology, Haifa, - - 2014
Polyglutamylation of antifolates catalyzed by folylpoly-γ-glutamate synthetase (FPGS) is essential for their intracellular retention and cytotoxic activity. Hence, loss of FPGS expression and/or function results in lack of antifolate polyglutamylation and drug resistance. Members of the TGF-β/Smad signaling pathway are negative regulators of hematopoiesis and deregulation of this pathway is ...
Skorvaga M - - 2014
The precise diagnosis of acute lymphoblastic leukemia is essential for correct prognosis assessment and therapy regimen selection. At present, immunophenotyping, cytogenetics and molecular screening are major and complementary methods utilized in a routine leukemia diagnostics. The aim of this study was to validate the application of multiplex reverse transcription-polymerase chain reaction ...
Quintás-Cardama Alfonso A Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX. Electronic address: - - 2014
Tripartite motif (TRIM)-62 is a putative tumor suppressor gene whose role in leukemia is unknown. We evaluated the effect of TRIM62 protein expression in patients with acute myeloid leukemia (AML). We used reverse-phase protein array methodology to determine TRIM62 levels in leukemia-enriched protein samples from 511 patients newly diagnosed with ...
Choi Dan-Bee DB Department of Laboratory Medicine, School of Medicine, Wonkwang University, Iksan, Republic of Korea; Center for Metabolic Function Regulation, Institute of Wonkwang Medical Science and Institute of Wonkwang Clinical Medicine, Wonkwang University, Iksan, Republic of - - 2014
We investigated three splicing factor proteins (SFPs; NSRP70, SRSF1, and HNRNPA1) in 187 adults with and without acute leukemia (AL). We showed that NSRP70 is a novel lymphoblastic AL (ALL) surrogate marker, which presented excellent diagnostic accuracy (92%) and disappeared during remission. Its highest molecular weight form, but not total ...
Wei Sixi S Hematopoietic Stem Cell Transplantation Center of Guizhou Province, Department of Hematology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550004, China; Department of Clinical Biochemistry, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550004, - - 2014
There are limited eligible clinical markers at present to monitor the progress of chronic myeloid leukemia (CML). Heme oxygenase-1 (HO-1), as one of the most important oxidation-regulating enzymes in vivo, suggests the onset and progression of cancer when highly expressed. Furthermore, HO-1 level is related with the occurrence and development ...
Zhu Hong H Department of Biomedical Engineering, College of Biology, Hunan University, Changsha, Hunan 410082, P.R. - - 2014
Deregulation of forkhead box (FOX) proteins has been found in many genetic diseases and malignancies including leukemia. Leukemia is a common neoplastic disease of the blood or bone marrow characterized by the presence of immature leukocytes and is one of the leading causes of death due to cancer. Forkhead transcription ...
Taha Masoumeh Fakhr MF Department of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Pajoohesh Boulevard, P.O. Box 14965-161, Tehran 1417863171, - - 2014
The expression pattern of pluripotency markers in adipose tissue-derived stem cells (ADSCs) is a subject of controversy. Moreover, there is no data about the signaling molecules that regulate these markers in ADSCs. In the present study, we studied the roles of leukemia inhibitory factor (LIF) and miR-302 in this regard. ...
Xu Lan L Department of Hematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, - - 2014
Background. Although the curative rate for acute promyelocytic leukemia (APL) has been improved over decades, long-term prognosis is still poor. The genetic pathways that regulated cell lineage fate during the development of APL remain unclear. Methods. We investigated the correlations of miR-146a expression with its target gene Smad4 and the ...
Liu S S Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People's Republic of - - 2014
Trophoblast cell migration and invasion are crucial for the establishment of a successful pregnancy. Protein O-fucosyltransferases, such as poFUT1 and poFUT2, catalyze the O-fucosylation of proteins and have important roles in embryonic development. Leukemia inhibitory factor (LIF) is a critical cytokine in the regulation of embryonic development and implantation. However, ...
Guo Hong H Department of Laboratory Center, The Affiliated People's Hospital of Jiangsu University Zhenjiang 212002, Jiangsu, People's Republic of China ; School of Medical Science and Laboratory Medicine, Jiangsu University Zhenjiang 212002, Jiangsu, People's Republic of - - 2014
Dysregulation of secreted frizzled-related protein 2 (SFRP2) has been found in various cancers. However, it is little known about the pattern of SFRP2 expression in acute myeloid leukemia (AML). This study was aimed to analyze the expression status of SFRP2 gene in AML patients and explore its clinical significance using ...
Niu Chang-Chun CC Department of Clinical Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China ; Department of Clinical Laboratory, The Third People's Hospital of Chongqing, Chongqing 400014, - - 2014
CCN1 plays distinct roles in various tumor types, but little is known regarding the role of CCN1 in leukemia. We analyzed CCN1 protein expression in leukemia cell lines and in AML bone marrow samples. We also evaluated the effects of antibody- or siRNA-mediated inhibition of CCN1 on the growth of ...
Du Yahui Y Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China. - - 2014
Suppressor with morphogenetic effect on genitalia family member (SMG1) belongs to a family of phosphoinositide 3-kinase-related kinases and is the main kinase involved in nonsense-mediated mRNA decay. Recently, SMG1 was suggested as a novel potential tumor suppressor gene, particularly in hypoxic tumors. To investigate the function of SMG1 in acute ...
Liu Zhuo - - 2012
Crystal-cell interactions play a key role in the formation of kidney stones. Few studies have referred to the role of monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor β1 (TGFβ1) in kidney stone formation. Recently, a genome-wide analysis of genes related to kidney stone formation and eliminiation in mice indicated ...
Li Xihai - - 2012
Millimeter waves, high-frequency electromagnetic waves, can effectively alleviate the clinical symptoms in osteoarthritis patients, as a non-pharmaceutical and non-invasive physical therapy regimen. However, the molecular mechanisms of the therapeutic effects of millimeter wave treatment are not well understood. In the present study, the effect of millimeter waves on the G1/S ...
Xu Jingyue - - 2012
Bone morphogenetic protein (BMP) signaling pathway plays important roles in urinary tract development although the detailed regulation of its activity in this process remains unclear. Here we report that follistatin-like 1 (Fstl1), encoding a secreted extracellular glycoprotein, is expressed in developing ureter and antagonizes BMP signaling activity. Mouse embryos carrying ...
Keller Kate E KE Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, - - 2011
Versican is a large proteoglycan with numerous chondroitin sulfate (CS) glycosaminoglycan (GAG) side chains attached. To assess versican's potential contributions to aqueous humor outflow resistance, its segmental distribution in the trabecular meshwork (TM) and the effect on outflow facility of silencing the versican gene were evaluated. Fluorescent quantum dots (Qdots) ...
Guan Yi - - 2011
Micro-RNAs (miRNAs) important for post-transcriptional gene expression as negative regulators are endogenous 21- to 23-nucleotide noncoding RNAs. Many miRNAs are expressed in ovarian cancer (OC). In this study, we reported that miR-125b was underexpressed in human OC specimens. Ectopic expression of miR-125b in OC cells induced cell cycle arrest and ...
Luna Coralia C Department of Ophthalmology, Duke University, Durham, North Carolina 27710, - - 2011
Cyclic mechanical stress (CMS) leads to alterations of cellular functions in the trabecular meshwork (TM), including the up-regulation of transforming growth factor beta 1 (TGFβ1), that can potentially contribute to the pathogenesis of glaucoma. Although microRNAs (miRNAs) are known to play important roles in many biological functions, little is known ...
Leeper Nicholas J NJ Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA. - - 2011
Aberrant smooth muscle cell (SMC) plasticity has been implicated in a variety of vascular disorders including atherosclerosis, restenosis, and abdominal aortic aneurysm (AAA) formation. While the pathways governing this process remain unclear, epigenetic regulation by specific microRNAs (miRNAs) has been demonstrated in SMCs. We hypothesized that additional miRNAs might play ...
Liu Ming - - 2011
miRNAs have emerged as post-transcriptional regulators that are critically involved in the pathogenesis of a number of human cancers. Cdc42, one of the best characterized members of the Rho GTPase family, is found to be up-regulated in several types of human tumors and has been implicated in cancer initiation and ...
Ghanim Husam - - 2011
High-fat, high-carbohydrate (HFHC) meals are known to induce oxidative and inflammatory stress, an increase in plasma endotoxin concentrations, and an increase in the expression of suppressor of cytokine signaling-3 (SOCS-3). The intake of a nutritional supplement containing resveratrol and muscadine grape polyphenols reduces HFHC meal-induced oxidative and inflammatory stress and ...
Kim Yeon Jeong - - 2011
MicroRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length that regulate gene expression at the posttranscriptional level. They may play important roles during osteogenic differentiation of adipose tissue-derived mesenchymal stem cells (hASC). In this chapter, we focus on the methods and strategies for elucidating miRNA function during osteogenic ...
Montgomery Rusty L - - 2011
In the last 10 years it has become increasingly clear that a large class of small noncoding RNAs, known as microRNAs (miRNAs) are potent and crucial regulators of important cellular processes such as differentiation, growth, and survival. miRNAs regulate gene expression through binding to 3' UTRs of target messenger RNAs ...
Winter Julia - - 2011
Aberrant expression of microRNAs (miRNAs) and processing defects in their biogenesis pathway are a widespread phenomenon in tumors, conveying great importance to the analysis of miRNA expression, regulation, and biogenesis to gain knowledge about their role in cancer. Besides Drosha and Dicer, Argonaute proteins are key players in miRNA processing. ...
Qin Shanshan - - 2011
MicroRNAs (miRNAs) are a novel class of endogenous, small, noncoding RNAs that regulate gene expression via degradation, translational inhibition, or translational activation of their target messenger RNAs. Functionally, an individual miRNA is important as a transcription factor because it is able to regulate the expression of its multiple target genes. ...
Chen Caifu - - 2011
MicroRNAs (miRNAs) are ∼22 nucleotide regulatory RNA molecules that play important roles in controlling developmental and physiological processes in animals and plants. Measuring the level of miRNA expression is a critical step in methods that study the regulation of biological functions and that use miRNA profiles as diagnostic markers for ...
Zhang Guo-Jun - - 2011
MicroRNA (miRNA), a large and growing class of 18-24-nucleotide long, noncoding RNA molecules in all known animal and plant genomes, is a key player in gene regulation. The functions of miRNA are yet to be understood with respect to how and where it is produced and the changes within an ...
Winter Julia - - 2011
MicroRNAs are short non-coding RNA molecules that are involved in diverse physiological and developmental processes by controlling the gene expression of target mRNAs. They play important roles in almost all kinds of cancer where they modulate key processes during tumorigenesis such as metastasis, apoptosis, proliferation, or angiogenesis. Depending on the ...
Havelange Violaine - - 2010
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by pairing with their target mRNAs, thereby inducing protein translation inhibition or/and mRNA degradation. There is now strong evidence that miRNAs play a crucial role in the regulation of hematopoiesis. Several groups have shown that miRNA expression change dynamically during ...
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