Search Results
Results 1 - 50 of 1794
1 2 3 4 5 6 7 8 9 10 >
Wilson Gabriel Josiah GJ Indiana University School of - - 2014
The anti-leukemic agent asparaginase triggers the amino acid response (AAR) in liver by activating the eukaryotic initiation factor 2 (eIF2) kinase GCN2. To explore the mechanism by which AAR induction is necessary to mitigate hepatic lipid accumulation and prevent liver dysfunction during continued asparaginase treatment, wild-type and Gcn2 null mice ...
Sun Xiujie X Institute for Nutritional Sciences, - - 2014
Energy metabolism follows a diurnal pattern responding to the cycles of light and food exposures. Although food availability is a potent synchronizer of peripheral circadian clock in mammals, the underlying mechanism remains elusive. Here, we found that the temporal signals of fasting and refeeding hormones regulate the transcription of Bmal1, ...
Lebeck Janne J Aarhus University, Health - - 2014
The peroxisome proliferator receptor α (PPARα) is a key regulator of the hepatic response to fasting with effects on both lipid and carbohydrate metabolism. A role in hepatic glycerol metabolism has also been found, however the results are somewhat contradictive. AQP9 is a pore-forming transmembrane protein that facilitates hepatic uptake ...
Liu Wei W Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Minhou, China; and Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Minhou, - - 2014
Hepatitis B virus core protein (HBc) has been implicated in hepatocarcinogenesis through several mechanisms. Resistance of hepatitis B virus (HBV)-infected hepatocytes to apoptosis is considered one of the major contributors to the progression of chronic hepatitis to cirrhosis and ultimately to hepatocellular carcinoma. The Fas receptor/ligand (Fas/FasL) system plays a ...
Rolland Marine M BioMar A/S, Mylius Erichsensvej 35, DK-7330 Brande, Denmark; Technical University of Denmark, DTU Aqua, Section for Aquaculture, The North Sea Research Center, P.O. Box 101, DK-9850 Hirtshals, Denmark. Electronic address: - - 2014
The effects of dietary level of methionine was investigated in juvenile rainbow trout (Oncorhynchus mykiss) fed five plant-based diets containing increasing content of crystalline methionine (Met), in a six weeks growth trial. Changes in the hepatic expression of genes related to i) the somatotropic axis: including the growth hormone receptor ...
Jiang Xin X Military Hygiene DepartmentFaculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, - - 2014
Dysmetabolic iron overload syndrome (DIOS) is frequently observed, but the underlying mechanism remains unclear. We propose the hypothesis that hyperinsulinemia, a common characteristic of DIOS, may stimulate liver transferrin receptor 1 (TFR1) expression via the PI3K/iron regulatory protein 2 (IRP2) pathway, leading to the occurrence of DIOS. The hepatic iron ...
Kim Geun Hyang - - 2014
Inflammation in response to excess low-density lipoproteins in the blood is an important driver of atherosclerosis development. Due to its ability to enhance ATP-binding cassette A1-dependent (ABCA1-dependent) reverse cholesterol transport (RCT), liver X receptor (LXR) is an attractive target for the treatment of atherosclerosis. However, LXR also upregulates the expression ...
Peiffer Kai-Henrik KH Goethe-University Hospital Frankfurt, Department of Gastroenterology and Hepatology, D-60590 Frankfurt am Main, Germany; Paul Ehrlich Institut, Division of Virology, D-63325 Langen, Germany. Electronic address: - - 2014
Hepatitis B virus genotype G (HBV/G) is characterized by a lack of HBeAg secretion and very low HBsAg secretion. This study aims to analyze HBV/G in comparison to HBV genotype A2 regarding morphogenesis and release of HBV-derived particles and to characterize factors contributing to HBV/G-associated pathogenesis. HBV/G and HBV/A expressing ...
Cho Hyun Kook - - 2014
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and chronic hepatitis B virus (HBV) infection is the most common risk factor for HCC. The HBV proteins can induce oncogenic effects or synergy effects with the hyperproliferative response on transformation into HCC. Cyclic-AMP-responsive-element-binding protein H (CREBH) activated by ...
Shan Xuefeng X Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, - - 2014
MicroRNAs (miRNAs) are a new class of well-conserved small noncoding RNAs that mediate posttranscriptional gene regulation. Hepatitis B virus (HBV) causes various liver diseases, including chronic hepatitis, liver cirrhosis and hepatocellular cancer. Recent data have indicated HBV alters miRNAs expression patterns, but the underlying mechanisms have not been fully established ...
Cho Young-Ah YA Department of Oral and Maxillofacial Pathology, School of Dentistry and Research Center for Tooth & Periodontal Regeneration (MRC), Kyung Hee University, Seoul, - - 2014
Melatonin's effect on hepatic differentiation of stem cells remains unclear. The aim of this study was to investigate the action of melatonin on hepatic differentiation as well as its related signaling pathways of human dental pulp stem cells (hDPSCs) and to examine the therapeutic effects of a combination of melatonin ...
Sinigaglia Alessandro A Department of Molecular Medicine, University of Padova, Padova, Italy; IOV Istituto Oncologico Veneto, Padova, - - 2014
MicroRNAs (miRNAs) have been involved in hepatocarcinogenesis, but little is known on their role in the progression of chronic viral hepatitis. Aim of this study was to identify miRNA signatures associated with stages of disease progression in patients with chronic viral hepatitis. MiRNA expression profile was investigated in liver biopsies ...
Wu Qian Q Shanghai Medical College of Fudan University, - - 2014
MicroRNA-122 (miR-122), a mammalian liver-specific miRNA, has been reported to play crucial roles in the control of diverse aspects of hepatic function and dysfunction, including viral infection and hepatocarcinogenesis. In this study, we explored the clinical significance, transcriptional regulation and direct target of miR-122 in hepatitis B virus (HBV)-associated hepatocellular ...
Hampel Miriam M University of Cadiz, Spain; - - 2014
Pharmaceuticals are pseudo persistent aquatic pollutants with unknown effects at environmentally relevant concentrations. Atlantic salmon (Salmo salar) were exposed to environmentally relevant concentrations of Acetaminophen; Atenolol and Carbamazepine for 5 days. After Acetaminophen treatment, 19 proteins were differently expressed, of which 11 were significant with respect to the control group ...
He Yingli Y Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an City, Shaanxi Province, 710061, China; Institution of Hepatology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an City, Shaanxi province, 710061, - - 2014
Acute liver failure (ALF) is a condition with high mortality and morbidity. Fibrosis in chronic liver disease were extensively researched, whereas fibrosis and underlying mechanism in acute liver failure remains unclear. HBV related ALF patients were recruited to investigate if there was ongoing fibrosis by liver histology and liver stiffness ...
Mei Bing B Department of Laboratory Medicine, Jingzhou Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jingzhou, Hubei 434020, P.R. - - 2014
Glucocorticoid receptor (GR) function is essential for glucocorticoid action on various effector cells. The aim of the present study was to investigate the mRNA expression profiles of GRα and GRβ in peripheral blood mononuclear cells (PBMC) and examine the association between the expression levels of the GR isoforms and the ...
Zhai Xuguang X Department of Biochemistry & Molecular Biology, Medical College, Nantong University, Nantong, 226001, Jiangsu, - - 2014
Curcumin exerts an inhibitory effect on hepatic stellate cell (HSC) activation, a key step for liver fibrogenesis, and on liver fibrosis by up-regulation of peroxisome proliferator-activated receptor- γ (PPARγ) expression. PPARγ plays a crucial role in suppression of HSC activation. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) functions as a co-activator for ...
Cheng Du D Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan, 430060, PR China; Liver Center, Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114; Liver Diseases Center, Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, 410011, PR - - 2014
Decreased levels of phosphatase and tensin homolog (PTEN) are associated with hepatocellular carcinoma (HCC) pathogenesis and poor prognosis in hepatitis C virus (HCV)-infected HCC patients. The molecular processes governing the reduction of PTEN and outcome of PTEN dysfunction in hepatocytes are poorly understood. The levels of proteins and mRNA were ...
Rosendale Andrew J AJ Department of Zoology, Miami University, Oxford, - - 2014
Glucose transporters (GLUTs) have been implicated in the survival of various physiological stresses in mammals; however, little is known about the role of these proteins in stress tolerance in lower vertebrates. The wood frog (Rana sylvatica), which survives multiple winter-related stresses by copiously mobilizing hepatic glycogen stores, is an interesting ...
Fenn Carlin M CM Center for Fisheries, Aquaculture and Aquatic Sciences, Southern Illinois University, Carbondale, IL 62901, USA; Department of Animal Science, Food, and Nutrition, Southern Illinois University, Carbondale, IL 62901, - - 2014
Sturgeon are a unique fish for physiological research as they are long-lived, slow-growing, and late-maturing. Furthermore, sturgeon growth hormones appear to share greater structural and molecular similarity with mammalian somatotropins than teleostean somatotropins. In this study, changes in insulin-like growth factor (IGF)-I and IGF-II mRNA expression and corresponding whole-body growth ...
Bae Kwi-Hyun KH Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, South - - 2014
Hepatic expression of fibroblast growth factor 21 (FGF21), one of the most promising therapeutic candidates for metabolic syndrome, is induced by multiple factors associated with fasting, including cyclic AMP response element-binding protein H (CREBH). Alpha lipoic acid (ALA), a naturally occurring thiol antioxidant, has been shown to induce metabolic changes ...
Li Xiaofei X Department of Infectious Diseases, Yiwu Central Hospital, Yiwu, Zhejiang 322000, P.R. - - 2014
Liver fibrosis is the common outcome of almost all cases of chronic liver disease. The hallmark of liver fibrosis is the activation of hepatic stellate cells (HSCs). microRNA‑34a (miR‑34a), which regulates a plethora of target proteins involved in the cell cycle, apoptosis, differentiation and cellular development, is found to be ...
Chiba Mitsuru M Department of Biomedical Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, - - 2014
The mature adult liver is a metabolizing and synthesizing organ consisting of hepatic lobules. The liver development during fetal stages is induced by the interaction between hepatoblast cells derived from the endoderm and stellate cells and/or endothelial cells derived from the mesoderm. Recently, the association of non-coding RNAs, such as ...
Zhao Xue-Ke XK Xue-Ke Zhao, Ming-Liang Cheng, Yu-Mei Yao, Mao Mu, Juan-Juan Zhu, Bao-Fang Zhang, Ming-Yu Zhou, Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou Province, - - 2014
To observe the effect of Danshao Huaxian capsule (DHC) on the expression of Gremlin and bone morphogenetic protein-7 (BMP-7) in the liver of hepatic fibrosis rats. A total of 75 male Wistar rats were randomly divided into a normal control group (A), a CCl4-induced hepatic fibrosis model group (B), a ...
Nomiyama Kei - - 2014
We have previously reported that high accumulation of dioxins and related compounds induced cytochrome P450 (CYP1s) isozymes in the liver of wild Baikal seals, implying the enhanced hydroxylation of polychlorinated biphenyls (PCBs). The present study attempted to elucidate the residue concentrations and patterns of PCBs and hydroxylated PCBs (OH-PCBs) in ...
Zhao Fanpeng F College of Life Sciences, Wuhan University, - - 2014
Hepatitis B virus (HBV) causes acute and chronic hepatitis in humans, and HBV infection is a major threat to global health. HBV replication is regulated by a series of host factors including microRNAs (miRNAs), which are highly conserved small noncoding RNAs that participate in a variety of physiological and pathological ...
Yang Yue Y Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, - - 2014
Non-alcoholic steatohepatitis (NASH) is a subset of non-alcoholic fatty liver disease, the most common chronic liver disease in the U.S. Fibrosis, a common feature of NASH, results from the dysregulation of fibrogenesis in hepatic stellate cells (HSCs). In this study, we investigated whether astaxanthin (ASTX), a xanthophyll carotenoid, can inhibit ...
Rada Patricia P Madrid, Spain ; - - 2014
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of oxidant and xenobiotic metabolism but it is unknown how is regulated to provide basal expression of this defense system. Here, we studied the putative connection between NRF2 and the canonical WNT pathway, which modulates hepatocyte metabolism. WNT-3A increased the ...
Chen Siyu S Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences (S.C., J.Q., X.S., T.G., T.L., C.L.), Nanjing Normal University, Nanjing, Jiangsu 210023, China; and State Key Laboratory of Natural Medicines (C.L.), China Pharmaceutical University, Nanjing, Jiangsu 210009, - - 2014
The promyelocytic leukemia zinc finger (PLZF) protein is involved in major biological processes including energy metabolism, although its role remains unknown. In this study, we demonstrated that hepatic PLZF expression was induced in fasted or diabetic mice. PLZF promoted gluconeogenic gene expression and hepatic glucose output, leading to hyperglycemia. In ...
Li Runsheng R 1 Weigang, Key Laboratory of Animal Physiology & Biochemistry, Nanjing Agricultural University, Nanjing, 210095, - - 2014
MicroRNA (miRNA) biogenesis is determined mainly by Drosha, Dicer and Argonaute2 (Ago2). Different breeds of pigs with vast differences in serum cortisol level demonstrate distinct profiles of hepatic miRNA expression. As yet, little is known about whether glucocorticoid contributes to the breed differences in miRNA biogenesis. Here, we used newborn ...
Shi Min M Department of Gastroenterology, Shanghai Changning Central Hospital, Shanghai 200336, P.R. - - 2014
Intrahepatic T helper (Th)17 cytokine and serum interleukin (IL)‑17 levels in patients with hepatitis B are positively correlated with the progression of liver cirrhosis (LC). IL‑35 can significantly inhibit the differentiation of Th17 cells and the synthesis of IL‑17. The present study aimed to investigate the function and expression of IL‑17 ...
de Brun V V Laboratorio de Técnicas Nucleares, Facultad de Veterinaria, Montevideo, - - 2014
This study investigated whether a 22-day period of undernutrition (half maintenance) could affect maternal endocrine responses and liver gene expression during early pregnancy (day 7). Thirty-five ewes were fed 1.5 (n = 15) or 0.5 (n = 20) their maintenance requirements and slaughtered on day 7 of the oestrus cycle or pregnancy (oestrus = day 0). ...
Tang Hei-Man Vincent HM Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong - - 2014
Transcription of hepatitis B virus (HBV) from the covalently closed circular DNA (cccDNA) template is essential for its replication. Suppressing the level and transcriptional activity of cccDNA might have anti-HBV effect. Although cellular transcription factors, such as CREB, which mediate HBV transcription, have been well described, transcriptional coactivators that facilitate ...
Lin Li L Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, No.1838 North of Guangzhou Road, Baiyun District, Guangzhou, 510515, People's Republic of - - 2014
microRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs, approximately 22 nucleotides (nts) in length, widely found in animals, plants, and viruses. Mature miRNAs control gene expression at a post-transcriptional level through blocking protein translation or inducing mRNA degradation. Many recent studies have shown that hepatitis B virus x protein (HBx), ...
Liu Hui H Department of Pathology, LABioMed at Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, - - 2014
Promoter CpG island hypermethylation is an important mechanism for inactivating key cellular enzymes that mediate epigenetic processes in hepatitis-related hepatocellular carcinoma (HCC). The ubiquitin-fold modifier 1 (Ufm1) conjugation pathway (Ufmylation) plays an essential role in protein degradation, protein quality control and signal transduction. Previous studies showed that the Ufmylation pathway ...
Xu Yajie Y Department of Pharmacology, Tianjin Medical University, TianJin, China; Department of Pharmacy, Second Affiliated Hospital of Tianjin University of TCM, Tianjin, - - 2014
The effect of Artesunate on anti-hepatic fibrosis was discovered by our team for the first time. In order to investigate the effect of Artesunate on hepatic fibrosis induced by Bovine serum albumin (BSA) in rats and understand the initiatory mechanism of its effect, several experiments were conducted in this assay. ...
Lei Yu Y Provincial Key Laboratory of Infectious Disease and Immunopathology, Department of Pathology, Shantou University Medical College, Shantou, - - 2014
The liver has the extraordinary properties of regeneration and immune tolerance; however, the mechanisms governing these abilities are poorly understood. To address these questions, we examined the possible expression of immunoglobulins in the human and rat liver and the relationship of IgG expression to hepatocyte proliferation, metastasis, apoptosis and immune ...
Seth Devanshi D Devanshi Seth, Paul S Haber, Drug Health Services, Royal Prince Alfred Hospital, Camperdown, NSW 2050, - - 2014
To investigate over-expression of Osteopontin (OPN) pathway expression and mechanisms of action in human alcoholic liver disease (ALD), in vivo and in vitro acute alcohol models. OPN pathway was evaluated in livers from patients with progressive stages of human ALD and serum from drinkers with and without liver cirrhosis. In ...
Gao Huijie H Jining Medical University, Jining 272067, PR - - 2014
MicroRNAs are a class of endogenous non-coding RNAs that regulate gene expression at post-transcriptional level, thus participating in diverse biological pathways. Increasing miRNAs are found to dysregulate hepatocellular carcinoma (HCC) and are involved in liver tumorigenesis. In this study, miR-429 was found to obviously downregulate much more in hepatitis B ...
Winters Stephen J SJ Division of Endocrinology, Metabolism and - - 2014
Context: The plasma level of sex hormone binding globulin (SHBG), a glycoprotein produced by hepatocytes, is subject to genetic, hormonal, metabolic, and nutritional regulation, and is a marker for the development of the metabolic syndrome and diabetes. Objective: Since the mechanism for these associations is unclear, and no studies of ...
Machado Sandrine P SP CIIMAR/CIMAR - Interdisciplinary Centre of Marine and Environmental Research, Laboratory of Environmental Toxicology, University of Porto, Rua dos Bragas, 289, 4050-123 Porto, - - 2014
The presence of carcinogenic compounds in the aquatic environment is a recognized problem. ABC transporters are well known players in the multidrug-resistance (MDR) phenomenon in mammals associated with resistance to chemotherapy, however little is known in fish species. Thus, the aim of this study was to induce hepatic tumours and ...
Feere D A DA Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, - - 2014
Erythropoietin (EPO) is used to treat anemia associated with chronic kidney disease (CKD). Hypoxia is associated with anemia and known to cause a decrease in cytochrome P450 (P450) expression. As EPO production is regulated by hypoxia, we investigated the role of EPO on P450 expression and function. Male Wistar rats ...
Cai Demin D Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural University,Nanjing210095,People's Republic of - - 2014
To elucidate the effects of maternal dietary betaine supplementation on hepatic expression of cholesterol metabolic genes in newborn piglets and the involved epigenetic mechanisms, we fed gestational sows with control or betaine-supplemented diets (3 g/kg) throughout pregnancy. Neonatal piglets born to betaine-supplemented sows had higher serum methionine concentration and hepatic content ...
Wang Ai-Guo AG Laboratory Animal Center, Dalian Medical University, Dalian, Liaoning 116000, PR China. Electronic address: - - 2014
Activation of RAS/ERK signaling pathway, depletion of retinoid, and phosphorylation of retinoid X receptor alpha (RXRα) are frequent events found in liver tumors and thought to play important roles in hepatic tumorigenesis. However, the relationships among them still remained to be elucidated. By exploring the transgenic mouse model of hepatic ...
Zollner Gernot G Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, - - 2014
Background: Drug-induced liver injury (DILI) is a major clinical problem and its pathogenesis is poorly understood. The association of DILI with polymorphisms in hepatobiliary transport systems suggests a role for transport proteins in the pathogenesis of DILI. Aim: To investigate expression and tissue distribution of hepatobiliary transport systems in DILI. ...
Bitter Andreas A Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376, Stuttgart, - - 2014
In addition to its well-characterized role in the regulation of drug metabolism and transport by xenobiotics, pregnane X receptor (PXR) critically impacts on lipid homeostasis. In mice, both ligand-dependent activation and knockout of PXR were previously shown to promote hepatic steatosis. To elucidate the respective pathways in human liver, we ...
Badolo Lassina L Discovery Chemistry and DMPK - - 2014
Abstract 1. Regulation of hepatic metabolism or transport may lead to increase in drug clearance and compromise efficacy or safety. In this study, cryopreserved human hepatocytes were used to assess the effect of 309 compounds on the activity and mRNA expression (using qPCR techniques) of CYP1A2, CYP2B6 and CYP3A4, as ...
Kim Dong-Il DI College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of - - 2014
Arginine methylation is responsible for diverse biological functions and is mediated by protein arginine methyltransferases (PRMTs). Nonalcoholic fatty liver disease (NAFLD) is accompanied by excessive hepatic lipogenesis via liver X receptor α (LXRα). Thus we examined the pathophysiological role of PRMTs in NAFLD and their relationship with LXRα. In this ...
Rasmussen Martin Krøyer MK Department of Food Science, Aarhus University, Denmark ; INSERM U1040, University of Montpellier, - - 2014
Cytochrome P450 (CYP450) is the major family of enzymes involved in the metabolism of several xenobiotic and endogenous compounds. Among substrates for CYP450 is the tryptophan metabolite skatole (3-methylindole), one of the major contributors to the off-odour associated with boar-tainted meat. The accumulation of skatole in pigs is highly dependent ...
Zhang Zhenzhen Z Department of Infectious Disease, Children's Hospital of Chongqing Medical University, No 136 ZhongShan Er Road, 400012, Chongqing, China, - - 2014
microRNAs (miRNAs) are small noncoding RNAs that modulate gene expression at the posttranscriptional level, playing an important role in many diseases. However, reports concerning the role of miRNA in hepatitis B virus (HBV) infection are limited. miRNA chips were used to investigate miRNA changes during HBV infection in vitro. Bioinformatics ...
1 2 3 4 5 6 7 8 9 10 >