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Böhm Michael - - 2010
BACKGROUND: Raised resting heart rate is a marker of cardiovascular risk. We postulated that heart rate is also a risk factor for cardiovascular events in heart failure. In the SHIFT trial, patients with chronic heart failure were treated with the selective heart-rate-lowering agent ivabradine. We aimed to test our hypothesis ...
Svensson Anders - - 2010
BACKGROUND: During computed tomography coronary angiography (CTCA) unexpected changes in heart rate while scanning may affect image quality. PURPOSE: To evaluate whether an iso-osmolar contrast medium (IOCM, iodixanol) and a low-osmolar contrast medium (LOCM, iomeprol) affect heart rate and experienced heat sensation differently. MATERIAL AND METHODS: One hundred patients scheduled ...
Barbon Alberto Rodriguez - - 2010
To establish reference values for the cardiac size during radiographic examination in 4 species of Falconiformes used for falconry, lateral and ventrodorsal radiographs were examined from healthy birds of 4 species: Harris' hawks (Parabuteo unicinctus) (n = 48), peregrine falcons (Falco peregrinus) (n = 35), saker falcons (Falco cherrug) (n ...
Kalabus James L JL Department of Pharmaceutical Sciences, The State University of New York at Buffalo, 545 Cooke Hall, Buffalo, NY 14260, - - 2010
Cancer patients with Down syndrome (DS) are susceptible to developing anthracycline-related cardiotoxicity. The pathogenesis of anthracycline-related cardiotoxicity has been linked to the intracardiac synthesis of alcohol metabolites by carbonyl reductase 1 (CBR1). CBR1 is located in the DS critical region (21q22.12). The expression of CBR1 in hearts from individuals with ...
Ishii Yasuo Y Cardiovascular Research Institute, University of California, San Francisco, 94158, - - 2010
The coronary vessels and epicardium arise from an extracardiac rudiment called the proepicardium. Failed fusion of the proepicardium to the heart results in severe coronary and heart defects. However, it is unknown how the proepicardium protrudes toward and attaches to the looping heart tube. Here, we show that ectopic expression ...
Rigatelli Gianluca - - 2010
The relationship between patent foramen ovale and migraine is a hotly debated issue. Conflicting data on the association or independence of these conditions have been reported by various study groups around the world. Now, a large-scale case-control study has shown no association between the two entities; however, there were a ...
Voogdt Kevin G J A - - 2010
BACKGROUND: Heart rate is a primary clinical indicator directing newborn resuscitation. The time taken to assess the heart rate by auscultation in relation to accuracy during newborn resuscitation is not known. OBJECTIVE: To assess both the accuracy and time taken to assess heart rate by stethoscope in simulated resuscitation scenarios. ...
Männer Jörg - - 2010
The heart is the first organ to function in vertebrate embryos. The human heart, for example, starts beating around the 21st embryonic day. During the initial phase of its pumping action, the embryonic heart is seen as a pulsating blood vessel that is built up by (1) an inner endothelial ...
Karamanlidis Georgios G Department of Medicine, University of Washington, Seattle, WA, - - 2010
Mitochondrial dysfunction plays a pivotal role in the development of heart failure. Animal studies suggest that impaired mitochondrial biogenesis attributable to downregulation of the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1 transcriptional pathway is integral of mitochondrial dysfunction in heart failure. The study sought to define mechanisms underlying the impaired mitochondrial ...
Ried Michael - - 2010
Primary cardiac T-cell lymphoma is an extremely rare entity, with only 3 patients having been reported so far in the literature. We describe the case of a young patient with acute heart failure involving the whole myocardium. The patient successfully underwent emergency cardiectomy, custom-made total artificial heart implantation and heart ...
Bruser Christoph C Philips Chair for Medical Information Technology, RWTH Aachen University, Germany. - - 2010
Ballistocardiography is a technique in which the mechanical activity of the heart is recorded. We present a novel algorithm for the detection of individual heart beats in ballistocardiograms (BCGs). In a training step, unsupervised learning techniques are used to identify the shape of a single heart beat in the BCG. ...
Kokubo Nobuhiro - - 2010
Vertebrate hearts have evolved from undivided tubular hearts of chordate ancestors. One of the most intriguing issues in heart evolution is the abrupt appearance of multichambered hearts in the agnathan vertebrates. To explore the developmental mechanisms behind the drastic morphological changes that led to complex vertebrate hearts, we examined the ...
Nakajima Yuji - - 2010
Abnormal heart development causes various congenital heart defects. Recent cardiovascular biology studies have elucidated the morphological mechanisms involved in normal and abnormal heart development. The primitive heart tube originates from the lateral-most part of the heart forming mesoderm and mainly gives rise to the left ventricle. Then, during the cardiac ...
Gokmen Zeynel - - 2009
The objective of this study was to determine differences between pediatrician and pediatric cardiologists regarding initial assessment of neonatal heart murmur and to evaluate the role of echocardiography in this group of patients. During a 6-month period, all term births in the obstetric unit at Faculty of Medicine, Gazi University, ...
Jensen Brian C BC Cardiology Section and Research Service, San Francisco VA Medical Center, San Francisco, Calif, - - 2009
alpha1-adrenergic receptors (alpha1-ARs) play adaptive roles in the heart and protect against the development of heart failure. The 3 alpha1-AR subtypes, alpha1A, alpha1B, and alpha1D, have distinct physiological roles in mouse heart, but very little is known about alpha1 subtypes in human heart. Here, we test the hypothesis that the ...
Gokmen Zeynel - - 2009
The objective of this study was to determine differences between pediatrician and pediatric cardiologists regarding initial assessment of neonatal heart murmur and to evaluate the role of echocardiography in this group of patients. During a 6-month period, all term births in the obstetric unit at Faculty of Medicine, Gazi University, ...
Grimes A C - - 2009
A large number of congenital heart defects associated with mortality in humans are those that affect the cardiac outflow tract, and this provides a strong imperative to understand its development during embryogenesis. While there is wide phylogenetic variation in adult vertebrate heart morphology, recent work has demonstrated evolutionary conservation in ...
Zimmermann Wolfram-Hubertus - - 2009
Children with severe congenital malformations, such as single-ventricle anomalies, have a daunting prognosis. Heart transplantation would be a therapeutic option but is restricted due to a lack of suitable donor organs and, even in case of successful heart transplantation, lifelong immune suppression would frequently be associated with a number of ...
Fink Martin M Department of Bioengineering, University of California, San Diego, La Jolla, CA 92037, - - 2009
The genetic basis of heart development is remarkably conserved from Drosophila to mammals, and insights from flies have greatly informed our understanding of vertebrate heart development. Recent evidence suggests that many aspects of heart function are also conserved and the genes involved in heart development also play roles in adult ...
Theofilogiannakos Efstratios K - - 2009
In cardiac transplantation has been recognized some "abnormalities" in recipient ECG. We investigated the influence of heart geometrical position within the chest cavity as well as somatometric parameters on body surface torso potentials. Two control patients with different Body Mass Index (BMI) were undergone a chest MRI scan. Using specific ...
Kärki S - - 2009
In this paper we propose a new simple method to measure the heart rate of a person sitting on a chair or lying in a bed. The heart rate is measured with a thin sensor pad consisting of separate electromechanical film (EMFi) and polyvinylidenefluoride (PVDF) transducers located beneath the leg ...
Cooper Ann S - - 2009
We present various methods to record cardiac function in the larval Drosophila. The approaches allow heart rate to be measured in unrestrained and restrained whole larvae. For direct control of the environment around the heart another approach utilizes the dissected larvae and removal of the internal organs in order to ...
Patronik Nicholas A - - 2009
Robotic assistance enhances conventional endoscopy; yet, limitations have hindered its mainstream adoption for cardiac surgery. HeartLander is a miniature mobile robot that addresses several of these limitations by providing precise and stable access over the surface of the beating heart in a less-invasive manner. The robot adheres to the heart ...
Vogler Georg - - 2009
The Drosophila heart has recently emerged as a good model system for examining the genetic, cellular, and molecular mechanisms underlying function in myogenic hearts. A key step in examining heart function in the fly is finding a way to access the heart in a manner that preserves its myogenic function ...
Dashkevich Alexey - - 2009
Terminal heart failure is associated with chronic myocardial edema, which in part is compensated by increased myocardial lymph flow. However, little is known about the impact of terminal heart failure on lymphangiogenesis. The purpose of the study was to investigate the morphological and quantitative changes of the initial myocardial lymphatics ...
Puran Bair - - 2009
Puran and Susanna Bair are cofounders of the Institute for Applied Meditation (IAM) in Tucson, Arizona. Known for his development of a type of meditation called heart rhythm meditation as well as development of scientific instrumentation to measure the physiological effects of this type of meditation, Puran Bair has a ...
Kriszbacher Ildik? - - 2010
We investigated whether the time of sunrise and the number of daylight hours have an effect on the seasonality, or the daily rhythm of heart attack mortality. We analyzed retrospectively data of patients admitted to hospitals with the diagnosis of heart attack (n=32,329) and patients who deceased of a heart ...
Männer Jörg - - 2008
The embryonic heart tube consists of an outer myocardial tube, a middle layer of cardiac jelly, and an inner endocardial tube. It is said that tubular hearts pump the blood by peristaltoid contractions. The traditional concept of cardiac peristalsis sees the cyclic deformations of pulsating heart tubes as concentric narrowing ...
Smodlaka H - - 2008
Anatomical properties of the ringed seal (Phoca hispida) heart and associated blood vessels reveal adaptations related to requirements for diving. Seven adult ringed seals were embalmed and dissected to document the gross anatomical features of the heart. Computed tomography images of the thoracic cavity were taken on one seal prior ...
Wythe, Joshua D.
The emergence of a functioning heart is critical for vertebrate embryogenesis and is dependent upon a highly conserved network of molecular cues and morphogenetic events. The critical nature of heart development, as well as its complexity, is underscored by the fact that of all congenital birth defects, congenital cardiac malformations ...
Ocorr Karen K Burnham Institute for Medical Research, Program for Systems and Developmental Biology, Center for Neuroscienes and Aging, La Jolla, CA 92037, - - 2007
The Drosophila heart has proven itself to be an excellent model for human cardiac development and recent investigations suggest that it may serve as a model for human heart function as well. Just as tinman-related genes underlie cardiac development in all organisms with a heart, the functional properties of mature ...
Jenkins Michael W MW Department of Biomedical Engineering, Case Western Reserve University, Ohio 44106, USA. - - 2007
We used optical coherence tomography (OCT) to characterize the morphological phenotype of embryonic murine hearts discerning hexamethylene-bis-acetamide-inducible protein 1 (HEXIM1) mutants from their wild-type littermates. At E12.5 and E13.5 murine embryos were excised from the mother, the hearts were removed, and 3D OCT data sets were obtained from each heart ...
Black Brian L BL Cardiovascular Research Institute and Department of Biochemistry and Biophysics, Mail Code 2240, University of California, San Francisco, California 94158-2517, USA. - - 2007
The heart is the first organ to form and function during vertebrate development and is absolutely essential for life. The left ventricle is derived from the classical primary or first heart field (FHF), while the right ventricle and outflow tract are derived from a distinct second heart field (SHF). The ...
Qian Kun-Xi - - 2007
Despite the progresses in developing pulsatile impeller pump and impeller total heart, as well as in applying streamlined impeller vanes, the best results in application of artificial heart pumps have been achieved by nonpulsatile univentricular assist pump with straight impeller vanes until now. It seems all efforts and successes have ...
Major Robert J - - 2007
Heart disease remains the leading cause of mortality throughout the world. Mammals have an extremely limited capacity to repair lost or damaged heart tissue, thus encouraging biologists to seek out models for heart regeneration. Zebrafish exhibit a robust regenerative capacity in a variety of tissues including the fin, spinal cord, ...
Takano Kazuhiro - - 2007
During vertebrate cardiac development, the heart tube formed by fusion of right and left presumptive cardiac mesoderms (PCMs) undergoes looping toward the right, resulting in an asymmetrical heart. Here, we examined the right and left PCMs with regard to heart-tube looping using right- and left-half newt embryos (Cynops pyrrhogaster ). ...
Broadbent Elizabeth - - 2006
OBJECTIVE: The objective of this study was to investigate how changes in heart attack patients' drawings of their heart over the recovery period relate to psychological and functional recovery. METHODS: Sixty-nine inpatients admitted for acute myocardial infarction at the coronary care unit at a metropolitan hospital completed questionnaires at discharge, ...
Hurst J Wills - - 2006
The New York Heart Association functional classification is commonly used because the value of its determination is generally appreciated. The other four parts of the classification (etiology, anatomy, physiology, and objective assessment) are used less often. The purpose of this paper is to point out the value of using the ...
Forouhar Arian S - - 2006
The embryonic vertebrate heart begins pumping blood long before the development of discernable chambers and valves. At these early stages, the heart tube has been described as a peristaltic pump. Recent advances in confocal laser scanning microscopy and four-dimensional visualization have warranted another look at early cardiac structure and function. ...
DeWitt Jamie C - - 2006
Necropsy-observable cardiac deformities were evaluated from 283 nestling passerines collected from one reference site and five polychlorinated biphenyl (PCB)-contaminated sites around Bloomington and Bedford, Indiana, USA. Hearts were weighed and assessed on relative scales in three dimensions (height, length, and width) and for externally visible deformities. Heart weights normalized to ...
V.L. Christensen
Embryo heart rates were measured on 400 fertilized turkey eggs (399 viable embryos) at 4 day intervals beginning at day 12 of development. Heart rates varied directly with eggshell porosity and were significantly and positively correlated with eggshell conductance (G) and conductance constants (k) but not with initial egg weight. ...
Shiojima Ichiro - - 2005
The heart is the first organ to form during embryogenesis, and heart formation is essential for subsequent embryonic development. Since the identification of a cardiac-restricted transcription factor Csx/Nkx-2.5 in the early 1990s, extensive studies on cardiac development have been done in various species ranging from flies to humans. Molecular dissection ...
Mannan S - - 2005
To study the circumference of atrioventricular orifices of the Bangladeshi adult people, fifty postmortem hearts were collected, fixed in 10% formol saline and examined. In the present paper, the findings were compared between male and female values and also with the findings of Western and Bangladeshi researchers. Among fifty hearts, ...
Barefoot John C - - 2005
The role of information search in the attribution of physiological states was investigated by manipulating the subject's opportunity for information search following the presentation of false information about his heart-rate reactions to photographs of female nudes. Consistent with the self-persuasion hypothesis proposed by Valins, the rated attractiveness of the slides ...
Singh Manvendra K - - 2005
Tbx20, a member of the T-box family of transcriptional regulators, shows evolutionary conserved expression in the developing heart. In the mouse, Tbx20 is expressed in the cardiac crescent, then in the endocardium and myocardium of the linear and looped heart tube before it is restricted to the atrioventricular canal and ...
Shi Yang - - 2005
Hearts from Brown Norway (BN/Mcw) rats are more resistant to ischemia than hearts from Dahl S (SS/Mcw) rats. We determined whether nitric oxide (.NO) is responsible for increased cardioprotection in BN/Mcw vs. SS/Mcw hearts. Hearts from the two strains were treated with N(G)-monomethyl-L-arginine (L-NMA) or S-nitrosoglutathione (GSNO) before ischemia and ...
Moorman Antoon F M - - 2004
In this communication we discuss the formation of the synchronously contracting chambered heart from a peristaltically contracting linear heart tube. It is proposed that members of the T-box family of transcription factors play a crucial role in the formation of the building plan of the formed heart. Tbx5 may confer ...
Yue Xinping - - 2004
Heparan sulfate (HS) has been shown to be involved in left-right asymmetry formation, including the process of dextral heart looping during embryonic development. The structural features of HS required in this process, however, have not been explored. In this study, we examined the structure of HS from the heart-forming regions ...
Salih Caner - - 2004
BACKGROUND: Hypoplastic left heart syndrome is a condition characterized by a constellation of morphological malformations affecting the left side of the heart. We studied the capillary network, and quantified the capillarization of the ventricular myocardium, which, if different from normal, may have implications for the success of surgical reconstruction. METHODS: ...
Zamir Evan A - - 2003
Cardiac looping, which begins with ventral bending and rightward rotation of the primitive heart tube, is an essential morphogenetic event that occurs early in vertebrate development. The biophysical mechanism that drives this process is unknown. It has been speculated that increased stiffness along the dorsal side of the ventricle combined ...
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