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Bleilevens C C Department of Anesthesiology, University Hospital Aachen, Pauwelsstrasse 30, 52074, Aachen, - - 2014
Cerebral injuries can trigger stress-related cardiomyopathy. The extent of cerebral injury and the involvement of the insular cortex influence the incidence and extent of myocardial injury (MI), and drugs with proven neuroprotective and cardioprotective properties such as levosimendan might be beneficial. This hypothesis was addressed in a rat model of ...
Zhu Gang-Jie GJ Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, - - 2014
The aim of this study was to explore myocardial protection of early extracorporeal membrane oxygenation (ECMO) support for acute myocardial infarction with cardiogenic shock in pigs. 24 male pigs (34.6 ± 1.3 kg) were randomly divided into three groups-control group, drug therapy group, and ECMO group. Myocardial infarction model was created in drug ...
Jiang Miaomiao - - 2014
Metabonomics is a useful tool for studying mechanisms of drug treatment using systematic metabolite profiles. Ginsenosides Rg1 and Rb1, ophiopogonin D, and schizandrin are the main bioactive components of a traditional Chinese formula (Sheng-Mai San) widely used for the treatment of coronary heart disease. It remains unknown the effect of ...
Kostić Jelena J Institute of Histology and Embryology "Aleksandar Đ. Kostić", School of Medicine, University of Belgrade, Višegradska 26, 11000 Belgrade, Serbia. Electronic address: - - 2014
Coronary artery thrombosis in ST-elevation myocardial infarction (STEMI) is a dynamic process often preceded by episodes of silent plaque rupture and subocclusive thrombosis. Thrombus organization is achieved by ingrowth of endothelial and smooth muscle cells. Clinical significance and impact of thrombus neovascularization on primary percutaneous coronary intervention (pPCI) outcome remain ...
Takematsu M M Division of Medical Toxicology, Department of Emergency Medicine, Montefiore Medical Center, Albert Einstein College of Medicine , New York, NY , - - 2014
Objective. Synthetic cannabinoids are increasingly used in the United States as marijuana substitutes. However, reports of severe toxicity, resulting from their use, are limited. We present the case of acute cerebral infarction following synthetic cannabinoid inhalation. Case report. A 33-year-old man with no significant medical history presented at the emergency ...
Haar Lauren L Shriners Hospital for Children and University of - - 2014
Previous studies have demonstrated improvement of cardiac function occurs with acute consumption high fat diet (HFD) after myocardial infarction (MI). However, no data exists addressing the effects of acute HFD upon the extent of injury after MI. This study investigates the hypothesis that short term HFD, prior to infarction, protects ...
Ye Xiaofeng X Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, - - 2014
Scalable units for building cardiac tissue are fabricated from biodegradable elastomeric polymers by pairwise stacking of heart cell scaffolds with sinusoidal internal pore architectures and dedicated perfusable microvessels with rapidly degrading porous interfaces in a parallel flow configuration. This platform supports viable heart cells in vitro and, if validated in ...
Ballas Samir K SK Cardeza Foundation for Hematologic Research, Department of Medicine, Jefferson Medical College, Thomas Jefferson University , Philadelphia, Pennsylvania , USA - - 2014
Abstract The most common cause of stroke in children with sickle cell anemia is infarction due to ischemia. In adults, however, stroke is most commonly hemorrhagic in nature. Other causes of stroke in patients with sickle cell disease are very rare. In this short communication, we describe a woman with ...
Castro-Ferreira Ricardo R Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, - - 2014
The myocardial response to acute stretch consists of a two-phase increase in contractility: an acute increase by the Frank-Starling mechanism and a gradual and time-dependent increase in force generated known as the slow force response (SFR). The SFR is actively modulated by different signaling pathways, but the role of protein ...
Li Zhiyuan Z Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China; Department of Cardiology, Shandong Provincial Taishan Hospital, Tai'an, Shandong, - - 2014
The neural remodeling of the atrium plays an important role in the initiation of atrial fibrillation after myocardial infarction (MI); however, the effects of the left stellate ganglion (LSG) on the neural remodeling of the atrium remain incompletely understood. Thus, this study investigated the mechanism by which the LSG mediates ...
Wan Chunxiao C , Rehabilitation Medicine Centre, Chinese PLA General Hospital, , - - 2014
Objective: To locate and trace endogenous endothelial progenitor cells (EPCs) in rabbits subjected to myocardial ischaemia and/or physiological ischaemia training. Methods: Rabbits were randomly divided into 4 groups: a myocardial ischaemia group (subjected to myocardial ischaemia only); a physiological ischaemia training group (subjected to physiological ischaemia training only); a physiological ...
Ramaiola Ilaria I Cardiovascular Research Center (CSIC-ICCC), IIB SantPau, c/Sant Antoni Mª Claret 167, 08025 Barcelona, - - 2014
Thrombus formation is a dynamic process regulated by flow, blood cells, and plasma proteins. The present study was performed to investigate the characteristics of human coronary thrombus in ST-segment elevation myocardial infarction (STEMI). Patients admitted with ST-elevation myocardial infarction, in which thrombectomy was performed, were included (n = 86). Intracoronary ...
Cohen Michael V MV From the Departments of Physiology University of South Alabama College of Medicine, Mobile, AL; From the Departments of Medicine, University of South Alabama College of Medicine, Mobile, - - 2014
Ischemic pre- and postconditioning are potent cardioprotective interventions that spare ischemic myocardium and decrease infarct size after periods of myocardial ischemia/reperfusion. They are dependent on complex signaling pathways involving ligands released from ischemic myocardium, G-protein-linked receptors, membrane growth factor receptors, phospholipids, signaling kinases, nitric oxide, protein kinase C and G, ...
Shen Yaqi Y Fudan University, School of Pharmacy, Department of Pharmacology, Shanghai, China ; - - 2014
Aims: Myocardial infarction (MI) is a leading cause of death globally. MicroRNAs have been identified as a novel class of MI injury regulators. Hydrogen sulfide (H2S) is a gaseous signaling molecule that regulates cardiovascular function. The purpose of this study was to explore the role of the miR-30 family in ...
Todica Andrei A Department of Nuclear Medicine, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, - - 2014
Several studies substantiate the cardioprotective effects of erythropoietin (EPO). Our goal was to quantify the effects of EPO treatment on the early expression of the apoptosis marker phosphatidylserine as well as on the left ventricular volumes and function by means of small animal PET. Myocardial infarction (MI) was induced in ...
Weinreuter Martin M Research Unit Cardiac Epigenetics, Department of Cardiology, University of Heidelberg, Heidelberg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, - - 2014
CaMKII was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. Here, we investigated the roles of different CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury by the use of new genetic CaMKII mouse models. Although CaMKIIδC was upregulated 1 day after I/R injury, cardiac damage 1 day after I/R ...
Wang Ping P Department of heart center Capital Medical University Affiliated Beijing Friendship - - 2014
Aims: Recently, a number of studies have shown an increased red blood cell distribution width (RDW) to be a strong and independent predictor of the prognosis of coronary artery disease. The aim of this study was to investigate the underlying mechanisms responsible for the relationship between the RDW and a ...
Polk Anne - - 2014
Cardiotoxicity is a serious side effect to treatment with 5-fluorouracil (5-FU), but the underlying mechanisms are not fully understood. The objective of this systematic review was to evaluate the pathophysiology of 5-FU- induced cardiotoxicity. We systematically searched PubMed for articles in English using the search terms: 5-FU OR 5-fluorouracil OR ...
Huang Timothy T Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, - - 2014
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is characterized by delay in depolarization of the right ventricle, detected by prolonged terminal activation duration (TAD) in V1-V3. However, manual ECG measurements have shown moderate-to-low intra- and inter-reader agreement. The goal of this study was to assess reproducibility of automated ECG measurements in the ...
Schwartz Jonathan G JG Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford University School of Medicine, Stanford, California, - - 2014
Invasive evaluation and treatment of coronary artery disease (CAD) has traditionally been based upon coronary angiography to determine the need for and the success of revascularization. However, coronary angiography augmented with fractional flow reserve (FFR) creates a paradigm shift, providing a more complete functional assessment of coronary lesions. Measuring FFR ...
Shevach Michal - - 2014
Decellularized matrices are valuable scaffolds for engineering functional cardiac patches for treating myocardial infarction. However, the lack of quick and efficient electrical coupling between adjacent cells may jeopardize the success of the treatment. To address this issue, we have deposited gold nanoparticles on fibrous decellularized omental matrices and investigated their ...
Wang Zhengbin Z Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, - - 2014
This paper introduces the research progress related to the antioxidant activity of bamboo leaf flavonoid (EOB-f) and its pharmacological activity of heart and cerebral vessels. The paper studied what role EOB-f played in the diagnosis of heart and cerebral vessels, based on the in vitro, in vivo and animal model ...
Luo Xiu-Ju - - 2014
Mitochondrial aldehyde dehydrogenase (ALDH2) is an isoenzyme of aldehyde dehydrogenases (ALDH), a group of enzymes that are responsible for clearance of aldehydes in the body. In animal myocardial or cerebral ischemia/reperfusion (I/R) models, accumulation of toxic aldehydes, such as 4-hydroxy-2-nonenal and malondialdehyde, is thought to be an important mechanism for ...
Wang Huishu H Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, China Affiliated Union Hospital, Fujian Medical University, - - 2014
Pharmacological preconditioning limits myocardial infarct size after ischemia/reperfusion. Dexmedetomidine is an α2-adrenergic receptor agonist used in anesthesia that may have cardioprotective properties against ischemia/reperfusion injury. We investigated whether dexmedetomidine induces cardioprotection against myocardial apoptosis injury. In order to assess the role of dexmedetomidine on myocardial apoptosis, we established a grave ...
Hastings Conn L CL Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephens Green, Dublin 2, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin (TCD), College Green, Dublin 2, Ireland; Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI & TCD, Dublin 2, - - 2014
The spectrum of ischemic cardiomyopathy, encompassing acute myocardial infarction to congestive heart failure is a significant clinical issue in the modern era. This group of diseases is an enormous source of morbidity and mortality and underlies significant healthcare costs worldwide. Cardiac regenerative therapy, whereby pro-regenerative cells, drugs or growth factors ...
Zhang Yan Y Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, - - 2014
This study aimed to investigate whether interferon regulatory factor 9 (IRF9) is involved in the pathogenesis of myocardial ischemia-reperfusion (I/R) injury and to explore the underlying molecular mechanisms of this process. Cell death plays a major role in myocardial I/R injury. We recently determined the importance of IRF9 in coordinating ...
Al-Amran Fadhil G FG Department of Surgery, Kufa University, Najaf, - - 2014
Background: Myocardial infarction is accompanied by inflammatory responses that lead to the recruitment of leukocytes and subsequent myocardial damage and healing. Monocyte chemoattractant protein-1 (MCP-1, also known as CC chemokine ligand 2) and its receptor CC chemokine receptor 2 play a central role in the inflammatory response and myocardial injury ...
Shimkunas Rafael R - - 2014
After myocardial infarction, a poorly contracting non-ischemic border zone forms adjacent to the infarct. The cause of border zone dysfunction is unclear. The goal of this study was to determine the myofilament mechanisms involved in post-infarction border zone dysfunction. Two weeks after anteroapical infarction of sheep hearts, we studied in-vitro ...
Barros Fernanda Silveira Bello FS Department of Obstetrics, Paulista School of Medicine - Federal University of São Paulo (EPM-UNIFESP), São Paulo, SP, - - 2014
To establish reference values for the volumes of fetal cardiac ventricular walls using three-dimensional ultrasonography (3DUS) and perform data validation using fetuses with confirmed congenital heart disease (CHD). This prospective, cross-sectional study analyzed 371 singleton pregnancies between 20w0d and 33w6d of gestation. Ventricular volumes were assessed using spatiotemporal image correlation ...
Aurich Matthias M Department of Internal Medicine III, Cardiology, Angiology and Pneumology, University of Heidelberg, Heidelberg, Germany. Electronic address: - - 2014
Routine quantitative assessment of left ventricular (LV) volumes with echocardiography is hindered by time-consuming methods requiring a manual trace of the LV cavity from two apical two-dimensional planes. Thus, the aim of this study was to evaluate faster new semiautomatic echocardiographic methods that could represent a feasible alternative for the ...
Kim Jiwon J Department of Cardiology, Memorial Sloan Kettering Cancer Center, New York, New - - 2014
The aim of this study was to assess the accuracy and reproducibility of real time three-dimensional echocardiographic (RT3DE) for the determination of right ventricular (RV) volumes and function in patients with left ventricular (LV) systolic dysfunction. Dedicated RT3DE was prospectively performed to assess RV volumes and EF in patients with ...
Mordi Ify I Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United - - 2014
Redo valve surgery is associated with increased risk of mortality that may be underestimated by current risk scores. In this study, we hypothesized that additional echocardiographic assessment of left ventricular diastolic and right ventricular systolic function would have independent prognostic value in the prediction of early postoperative mortality in patients ...
Orii Makoto M Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, - - 2014
We aimed to determine the predictive value of longitudinal, circumferential, and radial strains by two-dimensional speckle tracking echocardiography (2DSTE) for improvement in cardiac function after acute myocardial infarction (AMI) compared with that of contrast-enhanced cardiac magnetic resonance imaging (ceMRI). In 35 patients with first-time AMI, myocardial viability was assessed to ...
Chen Shaoqi S Department of Ultrasound, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, 515041, - - 2014
To explore the potential clinical usefulness and determine optimal diagnostic criteria of quantitative tissue velocity imaging and anatomic M-mode echocardiography in patients with coronary artery disease (CAD). We used quantitative tissue velocity imaging for the measurement of systolic myocardial velocity, and anatomic M-mode echocardiography for the measurement of ventricular wall-thickening ...
Cao Yuan-Yuan YY Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, 200032, - - 2014
Loss of left ventricular (LV) capture may lead to deterioration of heart failure in patients with CRT. Recognition of loss of LV capture in time is important in clinical practice. 422 electrocardiograms were acquired and analyzed from 53 CRT patients at 8 different pacing settings (LV-only, right ventricle (RV) only, ...
Trifunovic Danijela D Department of Cardiology, University Clinical Centre of Serbia, Belgrade, Serbia, - - 2014
Coronary microcirculatory function after primary percutaneous coronary intervention (pPCI) in patients with acute myocardial infarction is important determinant of infarct size (IS). Our aim was to investigate the utility of coronary flow reserve (CFR) and diastolic deceleration time (DDT) of the infarct artery (IRA) assessed by transthoracic Doppler echocardiography after ...
Figueredo Vincent M VM Einstein Institute for Heart and Vascular Health, Einstein Medical Center, Philadelphia, United States; Jefferson Medical College, Thomas Jefferson University, Philadelphia, United - - 2014
Increased activated Akt and eNOS expression coincide with this persistent cardioprotection. Emergent coronary reperfusion therapies are rarely carried out before considerable myocardial injury has occurred. Moreover, reperfusion after prolonged ischemia produces paradoxical ischemia-reperfusion injury, attenuating the efficacy of reperfusion therapies. This has provided impetus for identifying chronic therapies to protect ...
Luu Judy M JM Stephenson CMR Centre at the Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, - - 2014
To explore the impact of the functional severity of coronary artery stenosis on changes in myocardial oxygenation during pharmacological vasodilation, using oxygenation-sensitive cardiovascular magnetic resonance (OS-CMR) imaging and invasive fractional flow reserve (FFR). An FFR is considered a standard of reference for assessing haemodynamic relevance of coronary artery stenosis; yet, ...
Kandler Diana D Department of Diagnostic and Interventional Radiology, University Leipzig - Heart Centre, Strümpellstraße 39, 04289, Leipzig, - - 2014
Intramyocardial haemorrhage (IMH) and microvascular obstruction (MVO) represent reperfusion injury after reperfused ST-elevation myocardial infarction (STEMI) with prognostic impact and "hypointense core" (HIC) appearance in T2-weighted images. We aimed to distinguish between IMH and MVO by using T2 (*)-weighted cardiovascular magnetic resonance imaging (CMR) and analysed influencing factors for IMH ...
Rosso Charlotte C CRICM-Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, Paris, France INSERM, U1127; CNRS, UMR 7225, Paris, France COGIMAGE, Paris, France APHP, Service des Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, Paris, France Univ Paris 11, IFR49, DSV/I2BM/NeuroSpin, Bat 145, Gif-sur-Yvette, France INSERM, AP-HP, Centre d'Investigation Clinique CIC9503, Département des Maladies du Système Nerveux, Hôpital Pitié-Salpêtrière, Paris, France - - 2014
Background. The contribution of lesion size and location in poststroke aphasia is debated, especially the extent to which aphasia severity is affected by damage to specific white matter areas. Objective. To identify specific white matter areas critical for poststroke aphasia global severity and to determine whether injury to these areas ...
Kim Yeo Koon YK Department of Radiology, Institute of Radiation Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 110-744, - - 2014
To compare the image quality of late gadolinium enhancement (LGE) cardiac magnetic resonance imaging (CMR) using a single dose of gadolinium contrast agent versus the conventional double dose for assessing myocardial infarction. This retrospective study examined 37 patients with chronic myocardial infarction who underwent LGE CMR using both inversion recovery ...
Ercakmak Burcu B Department of Anatomy, Faculty of Medicine, Hacettepe University Sihhiye, Ankara, Turkey, - - 2014
In this study we aimed to compare the findings of coronary dual-source computed tomography angiography of myocardial bridges with cadaveric dissections. Forty-one isolated, non-damaged fresh sheep hearts were used in this study. Myocardial bridges of the anterior interventricular branch of the left coronary artery were demonstrated and analyzed by a ...
Ponte Marta M Cardiology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal, - - 2014
Computed tomography coronary angiography (CTA) and cardiac magnetic resonance myocardial perfusion imaging (CMR-MPI) are state-of-the-art tools for noninvasive assessment of coronary artery disease (CAD). We aimed to compare the diagnostic accuracy of CTA and CMR-MPI for the detection of functionally relevant CAD, using invasive coronary angiography (XA) with fractional flow ...
Li Li L Intensive Care Unit, Zhejiang Hospital, Hangzhou, Zhejiang 310013, - - 2014
Severe sepsis and septic shock are the leading causes of morbidity and mortality in hospitalized patients. This study aimed to investigate the association of poly (ADP-ribose) polymerase-1 (PARP-1) activity in circulating mononuclear cells with myocardial dysfunction in patients with septic shock. A total of 64 patients with septic shock were ...
Niccoli Giampaolo G aInstitute of Cardiology, Catholic University of the Sacred Heart bDepartment of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences Sapienza University of Rome cInstitute of Radiology, Department of Bioimaging and Radiological Sciences, Catholic University, Rome, - - 2014
Angiographic and electrocardiographic (ECG) indexes of microvascular obstruction (MVO) have been described. We aimed at assessing by cardiac magnetic resonance (CMR) anatomical features underlying concordance between them. Forty-one patients were enrolled. Patients presented with neither angiographic nor ECG indexes of MVO (without MVO) (44%), with either angiographic or ECG indexes ...
De Ferrari Gaetano M GM Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100, Pavia, Italy, - - 2014
Baroreflex sensitivity (BRS) measured several days after myocardial infarction (MI) is a powerful predictor of cardiovascular mortality. No information is available on BRS in the early hours of MI. The possibility to reliably assess BRS in the acute phase of MI and its clinical correlates were evaluated in 45 patients ...
Schaap Jeroen J Department of Cardiology, Amphia Hospital, PO Box 90158, 4800 RK, Breda, The Netherlands Department of Nuclear Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands - - 2014
Hybrid single photon emission computed tomography (SPECT)/coronary computed tomography angiography (CCTA) has only been evaluated for its diagnostic accuracy as a single test in patients suspected of significant coronary artery disease (CAD). Added value of hybrid SPECT/CCTA beyond usual clinical work-up, or use of each of these tests separately, remains ...
Gustavsen Kate A KA Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. Electronic address: - - 2014
To describe characteristics of echocardiography and cranial coelomic radiography in a cohort of iguanas. Twenty apparently healthy adult green iguanas (Iguana iguana) from a reptile sanctuary. Physical examination, radiography, two-dimensional and color Doppler echocardiography were performed to assess cardiac structures and function, and any related normal or abnormal findings were ...
Harada Kazuhiro K Department of Cardiology, Chubu Rosai Hospital, Nagoya, - - 2014
We assessed the hypothesis that the epicardial fat is associated with coronary lipid plaque. Epicardial fat volume (EFV) is increased in patients with acute coronary syndrome (ACS), and lipid-rich plaques have been associated with acute coronary events. We enrolled 112 individuals who underwent percutaneous coronary intervention (PCI) (66 with ACS; ...
Winklhofer Sebastian S Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, - - 2014
To investigate the accuracy of post-mortem diffusion tensor imaging (DTI) for the detection of myocardial infarction (MI) and to demonstrate the feasibility of helix angle (HA) calculation to study remodelling of myofibre architecture. Cardiac DTI was performed in 26 deceased subjects prior to autopsy for medicolegal reasons. Fractional anisotropy (FA) ...
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