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Huang Timothy T Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, - - 2014
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is characterized by delay in depolarization of the right ventricle, detected by prolonged terminal activation duration (TAD) in V1-V3. However, manual ECG measurements have shown moderate-to-low intra- and inter-reader agreement. The goal of this study was to assess reproducibility of automated ECG measurements in the ...
Schwartz Jonathan G JG Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford University School of Medicine, Stanford, California, - - 2014
Invasive evaluation and treatment of coronary artery disease (CAD) has traditionally been based upon coronary angiography to determine the need for and the success of revascularization. However, coronary angiography augmented with fractional flow reserve (FFR) creates a paradigm shift, providing a more complete functional assessment of coronary lesions. Measuring FFR ...
Luo Xiu-Ju - - 2014
Mitochondrial aldehyde dehydrogenase (ALDH2) is an isoenzyme of aldehyde dehydrogenases (ALDH), a group of enzymes that are responsible for clearance of aldehydes in the body. In animal myocardial or cerebral ischemia/reperfusion (I/R) models, accumulation of toxic aldehydes, such as 4-hydroxy-2-nonenal and malondialdehyde, is thought to be an important mechanism for ...
Zhang Yan Y Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, - - 2014
This study aimed to investigate whether interferon regulatory factor 9 (IRF9) is involved in the pathogenesis of myocardial ischemia-reperfusion (I/R) injury and to explore the underlying molecular mechanisms of this process. Cell death plays a major role in myocardial I/R injury. We recently determined the importance of IRF9 in coordinating ...
Shimkunas Rafael R - - 2014
After myocardial infarction, a poorly contracting non-ischemic border zone forms adjacent to the infarct. The cause of border zone dysfunction is unclear. The goal of this study was to determine the myofilament mechanisms involved in post-infarction border zone dysfunction. Two weeks after anteroapical infarction of sheep hearts, we studied in-vitro ...
Barros Fernanda Silveira Bello FS Department of Obstetrics, Paulista School of Medicine - Federal University of São Paulo (EPM-UNIFESP), São Paulo, SP, - - 2014
To establish reference values for the volumes of fetal cardiac ventricular walls using three-dimensional ultrasonography (3DUS) and perform data validation using fetuses with confirmed congenital heart disease (CHD). This prospective, cross-sectional study analyzed 371 singleton pregnancies between 20w0d and 33w6d of gestation. Ventricular volumes were assessed using spatiotemporal image correlation ...
Aurich Matthias M Department of Internal Medicine III, Cardiology, Angiology and Pneumology, University of Heidelberg, Heidelberg, Germany. Electronic address: - - 2014
Routine quantitative assessment of left ventricular (LV) volumes with echocardiography is hindered by time-consuming methods requiring a manual trace of the LV cavity from two apical two-dimensional planes. Thus, the aim of this study was to evaluate faster new semiautomatic echocardiographic methods that could represent a feasible alternative for the ...
Kim Jiwon J Department of Cardiology, Memorial Sloan Kettering Cancer Center, New York, New - - 2014
The aim of this study was to assess the accuracy and reproducibility of real time three-dimensional echocardiographic (RT3DE) for the determination of right ventricular (RV) volumes and function in patients with left ventricular (LV) systolic dysfunction. Dedicated RT3DE was prospectively performed to assess RV volumes and EF in patients with ...
Mordi Ify I Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United - - 2014
Redo valve surgery is associated with increased risk of mortality that may be underestimated by current risk scores. In this study, we hypothesized that additional echocardiographic assessment of left ventricular diastolic and right ventricular systolic function would have independent prognostic value in the prediction of early postoperative mortality in patients ...
Orii Makoto M Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, - - 2014
We aimed to determine the predictive value of longitudinal, circumferential, and radial strains by two-dimensional speckle tracking echocardiography (2DSTE) for improvement in cardiac function after acute myocardial infarction (AMI) compared with that of contrast-enhanced cardiac magnetic resonance imaging (ceMRI). In 35 patients with first-time AMI, myocardial viability was assessed to ...
Chen Shaoqi S Department of Ultrasound, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, 515041, - - 2014
To explore the potential clinical usefulness and determine optimal diagnostic criteria of quantitative tissue velocity imaging and anatomic M-mode echocardiography in patients with coronary artery disease (CAD). We used quantitative tissue velocity imaging for the measurement of systolic myocardial velocity, and anatomic M-mode echocardiography for the measurement of ventricular wall-thickening ...
Cao Yuan-Yuan YY Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, 200032, - - 2014
Loss of left ventricular (LV) capture may lead to deterioration of heart failure in patients with CRT. Recognition of loss of LV capture in time is important in clinical practice. 422 electrocardiograms were acquired and analyzed from 53 CRT patients at 8 different pacing settings (LV-only, right ventricle (RV) only, ...
Trifunovic Danijela D Department of Cardiology, University Clinical Centre of Serbia, Belgrade, Serbia, - - 2014
Coronary microcirculatory function after primary percutaneous coronary intervention (pPCI) in patients with acute myocardial infarction is important determinant of infarct size (IS). Our aim was to investigate the utility of coronary flow reserve (CFR) and diastolic deceleration time (DDT) of the infarct artery (IRA) assessed by transthoracic Doppler echocardiography after ...
Figueredo Vincent M VM Einstein Institute for Heart and Vascular Health, Einstein Medical Center, Philadelphia, United States; Jefferson Medical College, Thomas Jefferson University, Philadelphia, United - - 2014
Increased activated Akt and eNOS expression coincide with this persistent cardioprotection. Emergent coronary reperfusion therapies are rarely carried out before considerable myocardial injury has occurred. Moreover, reperfusion after prolonged ischemia produces paradoxical ischemia-reperfusion injury, attenuating the efficacy of reperfusion therapies. This has provided impetus for identifying chronic therapies to protect ...
Luu Judy M JM Stephenson CMR Centre at the Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, - - 2014
To explore the impact of the functional severity of coronary artery stenosis on changes in myocardial oxygenation during pharmacological vasodilation, using oxygenation-sensitive cardiovascular magnetic resonance (OS-CMR) imaging and invasive fractional flow reserve (FFR). An FFR is considered a standard of reference for assessing haemodynamic relevance of coronary artery stenosis; yet, ...
Kandler Diana D Department of Diagnostic and Interventional Radiology, University Leipzig - Heart Centre, Strümpellstraße 39, 04289, Leipzig, - - 2014
Intramyocardial haemorrhage (IMH) and microvascular obstruction (MVO) represent reperfusion injury after reperfused ST-elevation myocardial infarction (STEMI) with prognostic impact and "hypointense core" (HIC) appearance in T2-weighted images. We aimed to distinguish between IMH and MVO by using T2 (*)-weighted cardiovascular magnetic resonance imaging (CMR) and analysed influencing factors for IMH ...
Rosso Charlotte C CRICM-Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, Paris, France INSERM, U1127; CNRS, UMR 7225, Paris, France COGIMAGE, Paris, France APHP, Service des Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, Paris, France Univ Paris 11, IFR49, DSV/I2BM/NeuroSpin, Bat 145, Gif-sur-Yvette, France INSERM, AP-HP, Centre d'Investigation Clinique CIC9503, Département des Maladies du Système Nerveux, Hôpital Pitié-Salpêtrière, Paris, France - - 2014
Background. The contribution of lesion size and location in poststroke aphasia is debated, especially the extent to which aphasia severity is affected by damage to specific white matter areas. Objective. To identify specific white matter areas critical for poststroke aphasia global severity and to determine whether injury to these areas ...
Kim Yeo Koon YK Department of Radiology, Institute of Radiation Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 110-744, - - 2014
To compare the image quality of late gadolinium enhancement (LGE) cardiac magnetic resonance imaging (CMR) using a single dose of gadolinium contrast agent versus the conventional double dose for assessing myocardial infarction. This retrospective study examined 37 patients with chronic myocardial infarction who underwent LGE CMR using both inversion recovery ...
Ercakmak Burcu B Department of Anatomy, Faculty of Medicine, Hacettepe University Sihhiye, Ankara, Turkey, - - 2014
In this study we aimed to compare the findings of coronary dual-source computed tomography angiography of myocardial bridges with cadaveric dissections. Forty-one isolated, non-damaged fresh sheep hearts were used in this study. Myocardial bridges of the anterior interventricular branch of the left coronary artery were demonstrated and analyzed by a ...
Ponte Marta M Cardiology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal, - - 2014
Computed tomography coronary angiography (CTA) and cardiac magnetic resonance myocardial perfusion imaging (CMR-MPI) are state-of-the-art tools for noninvasive assessment of coronary artery disease (CAD). We aimed to compare the diagnostic accuracy of CTA and CMR-MPI for the detection of functionally relevant CAD, using invasive coronary angiography (XA) with fractional flow ...
Li Li L Intensive Care Unit, Zhejiang Hospital, Hangzhou, Zhejiang 310013, - - 2014
Severe sepsis and septic shock are the leading causes of morbidity and mortality in hospitalized patients. This study aimed to investigate the association of poly (ADP-ribose) polymerase-1 (PARP-1) activity in circulating mononuclear cells with myocardial dysfunction in patients with septic shock. A total of 64 patients with septic shock were ...
Niccoli Giampaolo G aInstitute of Cardiology, Catholic University of the Sacred Heart bDepartment of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences Sapienza University of Rome cInstitute of Radiology, Department of Bioimaging and Radiological Sciences, Catholic University, Rome, - - 2014
Angiographic and electrocardiographic (ECG) indexes of microvascular obstruction (MVO) have been described. We aimed at assessing by cardiac magnetic resonance (CMR) anatomical features underlying concordance between them. Forty-one patients were enrolled. Patients presented with neither angiographic nor ECG indexes of MVO (without MVO) (44%), with either angiographic or ECG indexes ...
De Ferrari Gaetano M GM Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100, Pavia, Italy, - - 2014
Baroreflex sensitivity (BRS) measured several days after myocardial infarction (MI) is a powerful predictor of cardiovascular mortality. No information is available on BRS in the early hours of MI. The possibility to reliably assess BRS in the acute phase of MI and its clinical correlates were evaluated in 45 patients ...
Schaap Jeroen J Department of Cardiology, Amphia Hospital, PO Box 90158, 4800 RK, Breda, The Netherlands Department of Nuclear Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands - - 2014
Hybrid single photon emission computed tomography (SPECT)/coronary computed tomography angiography (CCTA) has only been evaluated for its diagnostic accuracy as a single test in patients suspected of significant coronary artery disease (CAD). Added value of hybrid SPECT/CCTA beyond usual clinical work-up, or use of each of these tests separately, remains ...
Gustavsen Kate A KA Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. Electronic address: - - 2014
To describe characteristics of echocardiography and cranial coelomic radiography in a cohort of iguanas. Twenty apparently healthy adult green iguanas (Iguana iguana) from a reptile sanctuary. Physical examination, radiography, two-dimensional and color Doppler echocardiography were performed to assess cardiac structures and function, and any related normal or abnormal findings were ...
Harada Kazuhiro K Department of Cardiology, Chubu Rosai Hospital, Nagoya, - - 2014
We assessed the hypothesis that the epicardial fat is associated with coronary lipid plaque. Epicardial fat volume (EFV) is increased in patients with acute coronary syndrome (ACS), and lipid-rich plaques have been associated with acute coronary events. We enrolled 112 individuals who underwent percutaneous coronary intervention (PCI) (66 with ACS; ...
Winklhofer Sebastian S Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, - - 2014
To investigate the accuracy of post-mortem diffusion tensor imaging (DTI) for the detection of myocardial infarction (MI) and to demonstrate the feasibility of helix angle (HA) calculation to study remodelling of myofibre architecture. Cardiac DTI was performed in 26 deceased subjects prior to autopsy for medicolegal reasons. Fractional anisotropy (FA) ...
Platts David G DG Department of Echocardiography, The Prince Charles Hospital, Brisbane, Australia; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia; The University of Queensland, Brisbane, - - 2014
Transthoracic echocardiography (TTE) during extra corporeal membrane oxygenation (ECMO) is important but can be technically challenging. Contrast-specific TTE can improve imaging in suboptimal studies. These contrast microspheres are hydrodynamically labile structures. This study assessed the feasibility of contrast echocardiography (CE) during venovenous (VV) ECMO in a validated ovine model. Twenty-four ...
Ismail M M El Demerdash Hospital, Cardiology Department, Faculty of medicine Ain Shams University, Cairo, Egypt - - - 2014
We sought to explore the accuracy of the dobutamine--induced percent change of myocardial deformation indices to detect viability following myocardial infarction. We enrolled 60 consecutive patients presenting for myocardial viability assessment at least 4 weeks following ST--segment--elevation myocardial infarction. Strain (S) and strain rate (SR) were individually measured for all ...
Orde Sam R - - 2014
Speckle tracking echocardiography (STE) is a relatively novel and sensitive method for assessing ventricular function and may unmask myocardial dysfunction not appreciated with conventional echocardiography. The association of ventricular dysfunction and prognosis in sepsis is unclear. We sought to evaluate frequency and prognostic value of biventricular function, assessed by STE ...
Sugiyama Tomoyo T Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan; Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, - - 2014
Tissue prolapse (TP) is sometimes observed after percutaneous coronary intervention (PCI), but its clinical significance remains unclear. We investigated the relationship between TP volume on optical coherence tomography (OCT) after PCI and underlying plaque morphologies and the impact of TP on clinical outcomes. We investigated 178 native coronary lesions with ...
Leone Antonio Maria AM Institute of Cardiology, Catholic University of the Sacred Heart, Rome, - - 2014
Aims: The need of adenosine administration for the achievement of maximal hyperaemia limits the widespread application of fractional flow reserve (FFR) in the real world. We hypothesised that Pd/Pa ratio registered during submaximal reactive hyperaemia induced by conventional non-ionic radiographic contrast medium (contrast medium induced Pd/Pa ratio: CMR) can be ...
Mello Bruno Henrique Gallindo de BH Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, - - 2014
Background: The classification or index of heart failure severity in patients with acute myocardial infarction (AMI) was proposed by Killip and Kimball aiming at assessing the risk of in-hospital death and the potential benefit of specific management of care provided in Coronary Care Units (CCU) during the decade of 60. ...
Bartoli Carlo R CR Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United - - 2014
Background Left ventricular assist device (LVAD) thrombosis is a life-threatening complication that remains a major clinical problem. Consensus diagnostic criteria do not exist. We investigated whether hematologic, echocardiographic, or pump parameters reliably change during LVAD thrombosis. Methods A retrospective analysis of 20 consecutive cases of continuous-flow LVAD thrombosis (Thoratec HeartMate II n = 16, ...
Imola Fabrizio F aCardiology Department, San Giovanni Hospital, Rome, Italy bCentro per la Lotta contro l'Infarto (CLI) Foundation, Rome, Italy cSansavini Foundation, Ravenna, Italy dCentre for Inherited Cardiovascular Diseases, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Policlinico San Matteo, Pavia, - - 2014
Thrombus aspiration is useful in improving myocardial reperfusion in comparison to conventional percutaneous coronary intervention in patients with acute myocardial infarction. Nonetheless, assessment of thrombus aspiration efficacy is lacking. Aim of this study was to quantify by frequency domain optical coherence tomography (OCT) the amount of thrombus removal in patients ...
Rodrigo Sander F SF Department of Cardiology, Leiden University Medical Center, Leiden,The - - 2014
We previously showed that intramyocardial bone marrow cell (BMC) injection in patients with refractory angina and chronic myocardial ischemia improves myocardial perfusion, cardiac function and disease-related complaints. Treatment effect varied between patients, but the predictors of response remain to be identified. Therefore, the aim of the present study was to ...
Schindler Thomas H TH Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: - - 2014
Myocardial perfusion imaging with SPECT/CT or with PET/CT is a mainstay in clinical practice for the diagnostic assessment of downstream, flow-limiting effects of epicardial lesions during hyperemic flows and for risk stratification of patients with known or suspected coronary artery disease (CAD). In patients with multivessel CAD, the relative distribution ...
Soman Prem P Division of Cardiology, University of Pittsburgh, Pittsburgh, PA. Electronic address: - - 2014
Myocardial SPECT using standard procedure for perfusion imaging and phase analysis is a novel approach to left ventricular dyssynchrony assessment. Preliminary data suggest excellent repeatability and potential utility for guiding cardiac resynchronization therapy and elucidating mechanisms.
De Cecco Carlo Nicola CN 1 Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226, 25 Courtenay Dr, Charleston, SC - - 2014
OBJECTIVE. The purpose of this article is to prospectively determine the value of stress dual-energy CT (DECT) myocardial perfusion imaging to coronary CT angiography (CTA) for the assessment of coronary artery disease (CAD) in a high-risk population. SUBJECTS AND METHODS. We prospectively enrolled 29 consecutive patients who were referred for ...
Andersen Mads J MJ Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Department of Cardiology, Aarhus University Hospital, Brendstrupgårdsvej 100, DK-8200 Aarhus N, Aarhus, - - 2014
Recent hemodynamic studies have advanced our understanding of heart failure with preserved ejection fraction (HFpEF). Despite improved pathophysiologic insight, clinical trials have failed to identify an effective treatment for HFpEF. Invasive hemodynamic assessment can diagnose or exclude HFpEF, making it invaluable in understanding the basis of the disease. This article ...
Tu Shengxian S Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: - - 2014
This study sought to present a novel computer model for fast computation of myocardial fractional flow reserve (FFR) and to evaluate it in patients with intermediate coronary stenoses. FFR is an indispensable tool to identify individual coronary stenoses causing ischemia. Calculation of FFR from x-ray angiographic data may increase the ...
Nunes Caroline N M CN Faculdade de Medicina de Botucatu, Botucatu, SP, - - 2014
Abdominal obesity is an important cardiovascular risk factor. Therefore, identifying the best method for measuring waist circumference (WC) is a priority. To evaluate the eight methods of measuring WC in patients with acute coronary syndrome (ACS) as a predictor of cardiovascular complications during hospitalization. Prospective study of patients with ACS. ...
Pirich C C Department of Nuclear Medicine and Endocrinology, Paracelsus Medical University Salzburg,Salzburg, Austria - - - 2014
IQ SPECT consists of a new pinhole--like collimator, cardio--centric acquisition, and advanced 3D iterative SPECT reconstruction. to compare diagnostic accuracy and functional parameters obtained with IQ SPECT versus conventional SPECT in patients undergoing myocardial perfusion scintigraphy with adenosine stress and at rest. 80 patients with known or suspected coronary artery ...
Yokokawa Miki M Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, - - 2014
Twelve-lead electrocardiogram (ECG) criteria for epicardial ventricular tachycardia (VT) origins have been described. In patients with structural heart disease, the ability to predict an epicardial origin based on the QRS morphology is limited and has been investigated only for limited regions in the heart. The purpose of this study was ...
Larson Erik R ER The University of Texas at Austin, Department of Electrical Engineering, Austin, - - 2014
Implantable cardioverter defibrillators (ICDs) monitor intracardiac electrocardiograms (EGM) to discriminate between ventricular and supraventricular tachycardias. The incidence of inappropriate shocks remains high due to misclassification of the tachycardia in an otherwise hemodynamically stable individual. Coupling EGMs with an assessment of left ventricular (LV) stroke volume (SV) could help in gauging ...
Schuhbaeck Annika A Department of Cardiology, University of Erlangen, Ulmenweg 18, 91054, Erlangen, Germany, - - 2014
Quantitative measurements of coronary plaque volume may play a role in serial studies to determine disease progression or regression. Our aim was to evaluate the interscan reproducibility of quantitative measurements of coronary plaque volumes using a standardized automated method. Coronary dual source computed tomography angiography (CTA) was performed twice in ...
Berge H M HM Oslo Sports Trauma Research Center, Norwegian School of Sport Sciences, Oslo, - - 2014
Electrocardiogram (ECG) and echocardiography are mandatory in preparticipation cardiac screening in soccer players. Abnormal ECG findings usually require follow-up investigations. The main aim of this study was to compare the prevalence of abnormal ECG findings in male professional soccer players according to European Society of Cardiology's (ESC) recommendations and the ...
Uchiyama Yoshikazu Y Department of Medical Physics, Faculty of Life Science, Kumamoto University, 4-24-1 Kuhonji, Kumamoto, Kumamoto, 862-0976, Japan, - - 2014
Detection of lacunar infarcts is important because their presence indicates an increased risk of severe cerebral infarction. However, accurate identification is often hindered by the difficulty in distinguishing between lacunar infarcts and enlarged Virchow-Robin spaces. Therefore, we developed a computer-aided detection (CAD) scheme for the detection of lacunar infarcts. Although ...
Thapa Pooja P The First Affiliated Hospital of Liaoning Medical College, No. 2, Sec. 5, Renmin Road, Guta District, Jinzhou City, Liaoning Province, People's Republic of - - 2014
To assess the clinical utility of measuring mitral annulus displacement (MAD) by two-dimensional speckle tracking for the rapid evaluation of left ventricular longitudinal systolic function in patients with coronary heart disease (CHD). Left ventricular longitudinal systolic function was evaluated by MAD using speckle tracking echocardiography in 30 healthy volunteers (controls) ...
Trevisi Nicola N Arrhythmia Unit and Electrophysiology Laboratories, Ospedale San Raffaele, Via Olgettina 60, Milan, Italy - - 2014
To assess the efficacy of non-contact mapping for outflow tract premature ventricular contraction (PVC) and ventricular tachycardia (VT) ablation in patients without structural heart disease and a precordial transition at V3 or later and to determine the diagnostic accuracy of new virtual unipolar electrogram criteria for distinguishing left from right-sided ...
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