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Janicki Joseph S JS Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, 29208, USA, - - 2015
Cardiac mast cells store and release a variety of biologically active mediators, several of which have been implicated in the activation of matrix metalloproteinases in the volume-overloaded heart, while others are involved in the fibrotic process in pressure-overloaded hearts. Increased numbers of mast cells have been reported in explanted human ...
Yan Bingpeng B College of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210009, - - 2014
Undoubtedly, metabonomics can reveal the comprehensive efficacies of traditional Chinese medicine (TCM) formulae and its complex mechanism at the molecular biological level. In this study, an attempt was made to address the pretreatment effect of a TCM formula. In this case, as a critical point, we should first know how ...
Song Yi-Sun - - 2014
Human amniotic epithelial cells (h-AECs) have been shown to differentiate into cardiomyocyte-like cells in vivo that can regenerate myocardial tissue and improve cardiac function in a rat model of myocardial infarction (MI). In this study, we investigated the paracrine factors released from h-AECs under hypoxic conditions to elucidate the possible ...
Jiao Qibin Q Department of Cardiology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang Province, - - 2014
No-reflow after reperfusion therapy for myocardial infarction is a strong predictor of clinical outcome. Increased level of inflammatory factors including C-reactive protein (CRP) levels in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) may affect myocardial perfusion. However mechanisms that no-reflow increases in inflammation stress on ...
Li Jingbo J Division of Vascular Surgery, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. - - 2014
It has been previously reported that Toll‑like receptor 4 (TLR4)/NF‑κB signaling mediates early inflammation during myocardial ischemia and reperfusion. It has additionally been suggested that resveratrol produces cardioprotective and anti‑inflammatory effects. The aim of the present study was to investigate whether resveratrol could modulate TLR4/NF‑κB signaling, reduce neutrophil accumulation and TNF‑α ...
Ong S-B SB The Hatter Cardiovascular Institute, University College London, London, - - 2014
Mitochondria have long been known to be the gatekeeper of cell fate. This is particularly so in the response to acute ischaemia-reperfusion injury (IRI). Following an acute episode of sustained myocardial ischaemia, the opening of the mitochondrial permeability transition pore (MPTP) in the first few minutes of reperfusion, mediates cell ...
Thackeray James T JT Department of Nuclear Medicine, Hanover Medical School, Carl Neuberg-Str. 1, 30625, Hanover, - - 2014
Myocardial inflammation is an emerging target for novel therapies and thus for molecular imaging. Positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) has been employed, but requires an approach for suppression of cardiomyocyte uptake. We tested clinically viable strategies for their suitability in mouse models in order to optimize preclinical imaging ...
Michelucci Antonio A Section of Arrhythmology, Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy, - - 2014
The aim of the study was to evaluate the association between circulating (CPCs) and endothelial (EPCs) progenitor cells and left ventricular (LV) remodeling in chronic heart failure (HF). 85 HF patients, ranging 29-89 years, 83.5 % males, 45.9 % ischemic, NYHA functional class II-IV, with a LV ejection fraction ≤40 % were studied. LV ...
Theurl Markus M Medical University Innsbruck, University Hospital of Internal Medicine III, Department of Cardiology and - - 2014
Hypercholesterolemia is a major risk factor for cardiovascular diseases and has been shown to influence angiogenesis in the hind limb ischemia (HLI) model. The impaired up-regulation of angiogenic factors seems to be one of the underlying mechanisms for reduced vessel formation. Since we found that secretoneurin (SN) is up-regulated in ...
Bhaarathy V V Centre for Nanofibers & Nanotechnology, NUSNNI, Faculty of Engineering, National University of Singapore, 117576, Singapore; Department of Nanoscience and Technology, School of Physical Sciences, Bharathiar University, Coimbatore 641046, India; Lee Kong Chian School of Medicine, Nanyang Technological University, 138673, - - 2014
Nanofibrous structure developed by electrospinning technology provides attractive extracellular matrix conditions for the anchorage, migration and differentiation of stem cells, including those responsible for regenerative medicine. Recently, biocomposite nanofibers consisting of two or more polymeric blends are electrospun more tidily in order to obtain scaffolds with desired functional and mechanical ...
Ye Xiaofeng X Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, - - 2014
Scalable units for building cardiac tissue are created from biodegradable elastomeric polymers by L. E. Freed and co-workers on page 7202. The multilayered scaffolds are fabricated by pairwise stacking of heart-cell scaffolds with internal pore architectures and perfusable microvessels with rapidly degrading interfaces. This platform supports viable heart cells in ...
Cabrera-Fuentes H A - - 2014
Despite optimal therapy, the morbidity and mortality of patients presenting with an acute myocardial infarction (MI) remain significant, and the initial mechanistic trigger of myocardial "ischaemia/reperfusion (I/R) injury" remains greatly unexplained. Here we show that factors released from the damaged cardiac tissue itself, in particular extracellular RNA (eRNA) and tumour-necrosis-factor ...
Bonafè Francesca - - 2014
Hyaluronan (HA) is abundantly expressed in several human tissues and a variety of roles for HA has been highlighted. Particularly relevant for tissue repair, HA is actively produced during tissue injury, as widely evidenced in wound healing investigations. In the heart HA is involved in physiological functions, such as cardiac ...
Kim Donghyeon D School of Information and Communication, Gwangju Institute of Science and Technology, Gwangju, Republic of - - 2014
Strokes attributable to subcortical infarcts have been increasing recently in elderly patients. To gain insight how this lesion influences the motor outcome and responds to rehabilitative training, we used circumscribed photothrombotic capsular infarct models on 36 Sprague-Dawley rats (24 experimental and 12 sham-operated). We used 2-deoxy-2-[(18)F]-fluoro-D-glucose-micro positron emission tomography (FDG-microPET) ...
Ishikawa Kiyotake K Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY - - 2014
-Stem cell factor (SCF), a ligand of the c-kit receptor, is a critical cytokine which contributes to cell migration, proliferation, and survival. It has been shown that SCF expression increases after myocardial infarction (MI) and may be involved in cardiac repair. The aim of this study was to determine whether ...
Meng Cong C Department of Radiology, Huangdao Branch of the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266555, P.R. - - 2014
Oxysophoridine (OSR), a natural alkaloid derived from the traditional Chinese medicinal plant sophora alopecuroides, can perform a variety of pharmacological actions. The aim of the present study was to assess the cardioprotective effect of OSR against acute myocardial infarction (AMI) in rats. OSR markedly reduced infarction size and levels of ...
Lv Min M Department of Cardiovascular Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. - - 2014
The role of pterostilbene (Pte) in inflammation induced by ischemia/reperfusion is not well understood. The aim of this study was to investigate whether Pte modulates neutrophil accumulation and the induction of tumor necrosis factor-α (TNF‑α) in an ischemia/reperfusion (I/R)‑injured rat heart model. Rats were randomly exposed to a sham operation, ...
Toldo Stefano S Virginia Commonwealth University, Internal Medicine , 1220 E Broad Street, MMRB room 6040 , 1220 E Broad Street, MMRB room 6040 , Richmond, Virginia, United States, 23298 , 8043988646 ; - - 2014
Significance. An inflammatory response follows an injury of any nature, and while such response is an attempt to promote healing, it may itself result in further injury. Recent Advances. The inflammasome is a macromolecular structure recently recognized as a central mediator in the acute inflammatory response. The inflammasome senses the ...
Iglesias-Garcia Olalla O United States ; - - 2014
Stem cell-derived cardiomyocytes (CMs) are often electrophysiologically immature and heterogeneous, which represents a major barrier to their in vitro and in vivo application. Therefore, the purpose of this study was to examine whether Neuregulin-1b (NRG-1b) treatment could enhance in vitro generation of mature "working-type" CMs from induced pluripotent stem cells ...
Manskikh V N VN Faculty of Bioengineering and Bioinformatics, and Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia. - - 2014
Age-related changes in mammalian hearts often result in cardiac hypertrophy and fibrosis that are preceded by inflammatory infiltration. In this paper, we show that lifelong treatment of BALB/c and C57BL/6 mice with the mitochondria-targeted antioxidant SkQ1 retards senescence-associated myocardial disease (cardiomyopathy), cardiac hypertrophy, and diffuse myocardial fibrosis. To investigate the ...
Fargnoli A S AS Sanger Heart & Vascular Institute, Thoracic and Cardiac Surgery, Cannon Research Center, Carolinas Healthcare System, 1542 Garden Terrace, Charlotte, NC, 28203, - - 2014
This study evaluates needleless liquid jet method and compares it with three common experimental methods: (1) intramuscular injection (IM), (2) left ventricular intracavitary infusion (LVIC), and (3) LV intracavitary infusion with aortic and pulmonary occlusion (LVIC-OCCL). Two protocols were executed. First (n = 24 rats), retention of dye was evaluated 10 min after ...
Hermann Romina R Physiology Unit, Department of Biological Sciences, School of Pharmacy and Biochemistry, University of Buenos Aires and IQUIMEFA-CONICET, Buenos Aires, - - 2014
Although autophagy is a prominent feature of myocardial ischaemia and reperfusion, its functional significance is unclear and controversial. In order to gain a deeper insight into the role of autophagy in myocardial ischaemia-reperfusion, we explored the effects of the pharmacological inhibitor of autophagy 3-methyladenine (3-MA). Isolated rat atria subjected to ...
Fry Christopher H CH School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol, United Kingdom - - 2014
-We tested the hypothesis that alterations to action potential conduction velocity (CV) and conduction anisotropy in left ventricular hypertrophy are associated with topographical changes to gap-junction coupling and intracellular conductance by measuring these variables in the same preparations. -Left ventricular papillary muscles were excised from aortic-banded or sham-operated guinea-pig hearts. ...
Wang K K Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao 266021, - - 2014
Cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Cell death is a hallmark characteristic of various cardiac diseases, including myocardial infarction and heart failure. Emerging evidences suggest that necrosis is programmed and is one of the main forms of cell death in the pathological process in cardiac ...
Talbert Dominique R DR Quintiles Inc., Translational R&D - Oncology , 777 Oakmont Lane Suite #100, Westmont, IL 60559 - - 2014
Ponatinib, a multi-targeted TKI and potent pan-ABL inhibitor, approved for the treatment of Ph+ALL and CML, was temporarily withdrawn from the US market due to severe vascular adverse events. Cardiac-specific toxicities including myocardial infarction, severe congestive heart failure, and cardiac arrhythmias have also been shown with ponatinib. Targeted oncology agents ...
He Ke K Integration of Traditional Chinese and Western Medicine, School of Basic Medical Sciences, Peking - - 2014
Cardiac ischemia-reperfusion (I/R) injury remains a challenge for clinicians, which initiates with energy metabolism disorder. The present study was designed to investigate the protective effect of Notoginsenoside R1 (NR1) on I/R-induced cardiac injury and underlying mechanism. Male Sprague-Dawley rats were subjected to 30 min occlusion of left coronary anterior descending ...
Wang Qiang Q Department of Anesthesiology, Peking University People's Hospital, Beijing, China, - - 2014
To determine the optimal intervention time of the vagal stimulation (VS) attenuating myocardial ischemia/reperfusion injury (IRI). One hundred and twenty male SD rats were randomly allocated into six groups: sham group, IRI group, the VS performed at 15 min of ischemia (VSI15) group, the VS performed immediately before reperfusion (VSR0) group, ...
Rengarajan Balaji B Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, 401 Smyth Rd, Ottawa, Ontario, K1H 8L1, - - 2014
Spinal cord infarction is extremely rare in childhood and can result from a wide range of causes. Fibrocartilaginous embolism can give rise to spinal stroke and mimic non-vascular disease such as acute transverse myelitis. We report two children who suffered an asymmetrical spinal cord infarction due to fibrocartilaginous embolism. The ...
Inserte Javier J Laboratory of Experimental Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Barcelona, - - 2014
Cardiomyocyte cell death occurring during myocardial reperfusion (reperfusion injury) contributes to final infarct size after transient coronary occlusion. Different interrelated mechanisms of reperfusion injury have been identified, including alterations in cytosolic Ca(2+) handling, sarcoplasmic reticulum-mediated Ca(2+) oscillations and hypercontracture, proteolysis secondary to calpain activation, and mitochondrial permeability transition. All these ...
de Jong Renate R From the Department of Cardiology, Thorax Center, Erasmus University Medical Center, Rotterdam, The Netherlands (R.d.J., J.H.H., K.K.); Experimental Cardiology Laboratory, University and Medical Center Utrecht, The Netherlands (G.P.J.v.H., G.P., I.E.H.); BTG International Germany GmbH, Alzenau, Germany (C.W.); Biocompatibles UK Ltd, a BTG International Group Company, Farnham, United Kingdom (A.L.); and Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands - - 2014
Engraftment and survival of stem cells in the infarcted myocardium remain problematic in cell-based therapy for cardiovascular disease. To overcome these issues, encapsulated mesenchymal stem cells (eMSCs) were developed that were transfected to produce glucagon-like peptide-1, an incretin hormone with known cardioprotective effects, alongside MSC endogenous paracrine factors. This study ...
De Jesus Nicole M NM Department of Pharmacology, University of California, Davis, School of Medicine, Davis, CA; Department of Biomedical Engineering, University of California, Davis, School of Engineering; Davis, - - 2014
Atherosclerotic animal models show increased recruitment of inflammatory cells to the heart following myocardial infarction (MI), which impacts ventricular function and remodeling. To determine whether increased myocardial inflammation following MI also contributes to arrhythmias. MI was created in 3 mouse models: 1) atherosclerotic (ApoE(-/-) on atherogenic diet; n=12), 2) acute ...
Yoshikawa Noritada N Department of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Electronic address: - - 2014
Pulmonary hypertension (PH) sustains elevation of pulmonary vascular resistance and ultimately leads to right ventricular (RV) hypertrophy and failure and death. Recently, proangiogenic factors hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) have been known to promote left ventricular myocardial angiogenesis and lead to cardiac hypertrophy, and this ...
Conklin John J Department of Medical Imaging, University of Toronto, Toronto, - - 2014
Neuroimaging of older adults commonly reveals abnormality (leukoaraiosis) in the cerebral white matter. Studies have established that extensive leukoaraiosis predicts dementia and disability, but the pathogenesis of leukoaraiosis remains unclear. We recruited five patients with leukoaraiosis and performed magnetic resonance mapping of the brain for 16 consecutive weeks. We observed ...
Abe Yuzuru Y Department of Cardiovascular Medicine, Tohoku University Graduate School of - - 2014
Background:It has been previously demonstrated that extracorporeal low-energy shock-wave (SW) therapy ameliorates left ventricular (LV) remodeling through enhanced angiogenesis after acute myocardial infarction (AMI) in pigs in vivo. However, it remains to be examined whether SW therapy also exerts anti-inflammatory effects on AMI.Methods and Results:AMI was created by ligating the proximal left ...
Hassan Quamrul Q Research Scholar, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, - - 2014
Abstract Objective: The effects of benidipine on oxidative stress and myocardial apoptosis were assessed in isoproterenol (ISO) induced myocardial infarction (MI) in wistar rats. Material Method: Animals were pretreated with benidipine (1, 3, 10 μg/kg/day Body weight) intravenously for a period of 28 days. After pretreatment, ISO (85 mg/kg Body ...
Alam M R MR INSERM U1060, CarMeN Laboratory, Claude Bernard Lyon 1 University, F-69373 Lyon, - - 2014
Reperfusion is characterized by a deregulation of ion homeostasis and generation of reactive oxygen species that enhance the ischemia-related tissue damage culminating in cell death. The mitochondrial permeability transition pore (mPTP) has been established as an important mediator of ischemia-reperfusion (IR)-induced necrotic cell death. Although a handful of proteins have ...
Gao Yao Y Department of Geriatrics, First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, - - 2014
Cardiac fibrosis following myocardial infarction (MI) results in heart failure. Caveolin-1, the main structural protein of caveolae, regulates signal transduction pathways controlling cell proliferation and apoptosis. Meanwhile, low phosphatase and tensin homolog (PTEN) activity enhances the PI3K/Akt signal pathway to induce cell proliferation. But whether caveolin-1 and PTEN activation regulates ...
Bleilevens C C Department of Anesthesiology, University Hospital Aachen, Pauwelsstrasse 30, 52074, Aachen, - - 2014
Cerebral injuries can trigger stress-related cardiomyopathy. The extent of cerebral injury and the involvement of the insular cortex influence the incidence and extent of myocardial injury (MI), and drugs with proven neuroprotective and cardioprotective properties such as levosimendan might be beneficial. This hypothesis was addressed in a rat model of ...
Zhu Gang-Jie GJ Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, - - 2014
The aim of this study was to explore myocardial protection of early extracorporeal membrane oxygenation (ECMO) support for acute myocardial infarction with cardiogenic shock in pigs. 24 male pigs (34.6 ± 1.3 kg) were randomly divided into three groups-control group, drug therapy group, and ECMO group. Myocardial infarction model was created in drug ...
Boštjančič Emanuela E Emanuela Boštjančič, Damjan Glavač, Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, - - 2014
MicroRNAs (miRNAs), which are small and non-coding RNAs, are genome encoded from viruses to humans. They contribute to various developmental, physiological and pathological processes in living organisms. A huge amount of research results revealed that miRNAs regulate these processes also in the heart. miRNAs may have cell-type-specific or tissue-specific expression ...
Jiang Miaomiao - - 2014
Metabonomics is a useful tool for studying mechanisms of drug treatment using systematic metabolite profiles. Ginsenosides Rg1 and Rb1, ophiopogonin D, and schizandrin are the main bioactive components of a traditional Chinese formula (Sheng-Mai San) widely used for the treatment of coronary heart disease. It remains unknown the effect of ...
Kostić Jelena J Institute of Histology and Embryology "Aleksandar Đ. Kostić", School of Medicine, University of Belgrade, Višegradska 26, 11000 Belgrade, Serbia. Electronic address: - - 2014
Coronary artery thrombosis in ST-elevation myocardial infarction (STEMI) is a dynamic process often preceded by episodes of silent plaque rupture and subocclusive thrombosis. Thrombus organization is achieved by ingrowth of endothelial and smooth muscle cells. Clinical significance and impact of thrombus neovascularization on primary percutaneous coronary intervention (pPCI) outcome remain ...
Takematsu M M Division of Medical Toxicology, Department of Emergency Medicine, Montefiore Medical Center, Albert Einstein College of Medicine , New York, NY , - - 2014
Objective. Synthetic cannabinoids are increasingly used in the United States as marijuana substitutes. However, reports of severe toxicity, resulting from their use, are limited. We present the case of acute cerebral infarction following synthetic cannabinoid inhalation. Case report. A 33-year-old man with no significant medical history presented at the emergency ...
Haar Lauren L Shriners Hospital for Children and University of - - 2014
Previous studies have demonstrated improvement of cardiac function occurs with acute consumption high fat diet (HFD) after myocardial infarction (MI). However, no data exists addressing the effects of acute HFD upon the extent of injury after MI. This study investigates the hypothesis that short term HFD, prior to infarction, protects ...
Ye Xiaofeng X Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, - - 2014
Scalable units for building cardiac tissue are fabricated from biodegradable elastomeric polymers by pairwise stacking of heart cell scaffolds with sinusoidal internal pore architectures and dedicated perfusable microvessels with rapidly degrading porous interfaces in a parallel flow configuration. This platform supports viable heart cells in vitro and, if validated in ...
Ballas Samir K SK Cardeza Foundation for Hematologic Research, Department of Medicine, Jefferson Medical College, Thomas Jefferson University , Philadelphia, Pennsylvania , USA - - 2014
Abstract The most common cause of stroke in children with sickle cell anemia is infarction due to ischemia. In adults, however, stroke is most commonly hemorrhagic in nature. Other causes of stroke in patients with sickle cell disease are very rare. In this short communication, we describe a woman with ...
Castro-Ferreira Ricardo R Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, - - 2014
The myocardial response to acute stretch consists of a two-phase increase in contractility: an acute increase by the Frank-Starling mechanism and a gradual and time-dependent increase in force generated known as the slow force response (SFR). The SFR is actively modulated by different signaling pathways, but the role of protein ...
Li Zhiyuan Z Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China; Department of Cardiology, Shandong Provincial Taishan Hospital, Tai'an, Shandong, - - 2014
The neural remodeling of the atrium plays an important role in the initiation of atrial fibrillation after myocardial infarction (MI); however, the effects of the left stellate ganglion (LSG) on the neural remodeling of the atrium remain incompletely understood. Thus, this study investigated the mechanism by which the LSG mediates ...
Agnić Ivan I Department of Anesthesiology, University Hospital Split, Split, Croatia. Electronic address: - - 2014
The application of isoflurane in a postconditioning manner, during early reperfusion of ischemic myocardium, reduces the infarct size. Its favorable effect on highly vascularized granulation tissue formation is very important considering the fact that increased genesis of blood vessels in peri-infarct zone reduces the infarct size and improves cardiac function. ...
Wan Chunxiao C , Rehabilitation Medicine Centre, Chinese PLA General Hospital, , - - 2014
Objective: To locate and trace endogenous endothelial progenitor cells (EPCs) in rabbits subjected to myocardial ischaemia and/or physiological ischaemia training. Methods: Rabbits were randomly divided into 4 groups: a myocardial ischaemia group (subjected to myocardial ischaemia only); a physiological ischaemia training group (subjected to physiological ischaemia training only); a physiological ...
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