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Janicki Joseph S JS Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, 29208, USA, - - 2015
Cardiac mast cells store and release a variety of biologically active mediators, several of which have been implicated in the activation of matrix metalloproteinases in the volume-overloaded heart, while others are involved in the fibrotic process in pressure-overloaded hearts. Increased numbers of mast cells have been reported in explanted human ...
Liao Zhangping Z State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, P. R. China; Department of Pharmacology & Molecular Therapeutics, Nanchang University School of Pharmaceutical Science, Nanchang, 330006, P. R. - - 2014
This study elucidates effects of long term nutritional preconditioning by resveratrol on I/R injury and its underlying mechanisms. Mice were treated with resveratrol at 2.0 mg/kg.day by gastric gavages for 6 weeks. Then hearts were isolated and subjected to I/R injury in a Langendorff apparatus. Resveratrol significantly improved LVP, ±dp/dtmax ...
Wang Yiming - - 2014
BackgroundMajor depressive disorder (MDD) is an independent risk factor for coronary heart disease (CHD), and influences the occurrence and prognosis of cardiovascular events. Although there is evidence that antidepressants may be cardioprotective after acute myocardial infarction (AMI) comorbid with MDD, the operative pathophysiological mechanisms remain unclear. Our aim was therefore ...
Ye Lei L Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN, 55455, - - 2014
Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required to determine optimal cell preparation and delivery strategies to maximize functional benefits and to evaluate safety. Here, we utilized a porcine model of acute myocardial infarction (MI) to ...
Chullikana Anoop A Stempeutics Research Pvt Ltd, Bangalore, India, and Stempeutics Research Manipal - - 2014
Cell therapy is promising as an exploratory cardiovascular therapy. We have recently developed an investigational new drug named Stempeucel (bone marrow-derived allogeneic mesenchymal stromal cells) for patients with acute myocardial infarction (AMI) with ST-segment elevation. A phase I/II randomized, double-blind, single-dose study was conducted to assess the safety and efficacy ...
Liu Yu-Wei YW Departments of Geriatrics, and Hyperbaric Oxygen Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. - - 2014
Morbidities related to atherosclerosis, such as acute coronary syndrome (ACS), remain the leading cause of mortality. Axl is a receptor tyrosine kinase that is expressed in mammalian vascular and immune cells. Axl signaling is involved in the regulation of the inflammatory response. A considerable amount of evidence indicates that inflammation ...
Bielmann Christelle C Division de Physiopathologie Clinique, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Bugnon 7a, 1005, Lausanne, - - 2015
Brain natriuretic peptide (BNP) contributes to heart formation during embryogenesis. After birth, despite a high number of studies aimed at understanding by which mechanism(s) BNP reduces myocardial ischemic injury in animal models, the actual role of this peptide in the heart remains elusive. In this study, we asked whether BNP ...
Liu Zheng Z Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu & Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, - - 2014
-MicroRNAs (miRs) and inflammatory monocytes participate in many cardiac pathophysiological processes including acute myocardial infarction (AMI). Recently, we observed that miR-150 is downregulated in injured mouse plasma after AMI as well as in human infarcted monocytes. However, the precise functional role of miR-150 in response to AMI remains unknown. -In ...
Zuurbier Coert J - - 2014
BackgroundAcute, high-dose folic acid (FA) administration has recently been shown to possess unprecedented effective cardioprotection against ischaemia/reperfusion (I/R) injury. Here we explore the translation potential of FA as treatment modality for cardiac I/R.MethodsDependency of FA protection on dose, ischaemia duration, and eNOS was examined in an isolated mouse heart I/R ...
Sepúlveda Diana E DE Department of Pathology, Universidad Favaloro, Solís 453, Buenos Aires, - - 2014
The adult heart contains a population of cardiac progenitor cells (CPCs). Growing and collecting an adequate number of CPCs demands complex culture media containing growth factors. Since activated macrophages secrete many growth factors, we investigated if activated isolated heart cells seeded on a feeder layer of activated peritoneal macrophages (PM) ...
Yuan Chujun C Department of Cell Biology & Molecular Medicine, and the Cardiovascular Research Institute at Rutgers University, New Jersey Medical School, Newark, NJ - - 2014
Promoting angiogenesis is a key therapeutic target for protection from chronic ischemic cardiac injury. Endothelial-Monocyte-Activating-Polypeptide-II (EMAP II) protein, a tumor-derived cytokine having anti-angiogenic properties in cancer, is markedly elevated following myocardial ischemia. We examined whether neutralization of EMAP II induces angiogenesis and has beneficial effects on myocardial function and structure ...
Dixit Sanjay S Section of Cardiac Electrophysiology, Division of Cardiology, Hospital of The University of Pennsylvania, - - 2014
Outflow tract ventricular tachycardias (OTVT) are the commonest type of idiopathic VT.(1) As the name suggests, these arrhythmias originate in the OT region of the right and left ventricles (RV and LV, respectively), the most common sites being the superior septal RVOT and the aortic cusp region.(2,3) Other less common ...
Efthimiadis Georgios K GK 1Cardiomyopathies Laboratory, First Department of Cardiology, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece 2Third Cardiology Department, Hippokrateion Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece 3Laboratory of Histology and Embryology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece 4Institute of Cardiovascular Science, University College London, London, - - 2014
Preclinical diagnosis in hypertrophic cardiomyopathy (HCM) refers to the detection of functional or histopathological abnormalities in subjects who carry any HCM-causing gene mutation, before or even without the development of left ventricular hypertrophy [genotype(+) /phenotype(-) subjects]. The concept that HCM pathology, may exist in the absence of left ventricular hypertrophy ...
Kainuma Satoshi S Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, - - 2014
Cell-sheet transplantation induces angiogenesis for chronic myocardial infarction (MI), though insuf?cient capillary maturation and paucity of arteriogenesis may limit its therapeutic effects. Omentum has been used clinically to promote revascularization and healing of ischemic tissues. We hypothesized that cell-sheet transplantation covered with an omentum-flap would effectively establish mature blood vessels ...
Chen Yin Y Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Hong Kong, - - 2014
Microgrooved thin PLGA film (≈30 μm) is successfully fabricated on a Teflon mold, which could be readily peeled off and is used for the construction of a biomimetic cardiac patch. The contraction of it is studied with optical mapping on transmembrane action potential. Our results suggest that steady-state contraction could be ...
Qin Chengxue C Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, - - 2014
Myocardial infarction (MI) and its resultant heart failure remains a major cause of death in the world. The current treatments for patients with MI are revascularization with thrombolytic agents or interventional procedures. These treatments have focused on restoring blood flow to the ischemic tissue to prevent tissue necrosis and preserve ...
Tanaka Yasutaka Y Department of Neurology, Juntendo University School of Medicine, Tokyo, - - 2014
Kimura disease (KD) is an uncommon chronic inflammatory disease presenting as subcutaneous lymphadenopathy with eosinophilia. To date, only a single case of brain embolism caused by fibroblastic endocarditis associated with KD has been reported. Watershed infarction was seen in patients with episodes of severe hypotension or cardiac surgery. We here ...
Yan Bingpeng B College of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210009, - - 2014
Undoubtedly, metabonomics can reveal the comprehensive efficacies of traditional Chinese medicine (TCM) formulae and its complex mechanism at the molecular biological level. In this study, an attempt was made to address the pretreatment effect of a TCM formula. In this case, as a critical point, we should first know how ...
Zhang Liying L Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, - - 2014
-Induced pluripotent stem cells (iPSCs) can be differentiated into potentially unlimited lineages of cell types for use in autologous cell therapy. However, the efficiency of the differentiation procedure and subsequent function of the iPSC-derived cells may be influenced by epigenetic factors that the iPSCs retain from their tissues of origin; ...
Song Yi-Sun - - 2014
Human amniotic epithelial cells (h-AECs) have been shown to differentiate into cardiomyocyte-like cells in vivo that can regenerate myocardial tissue and improve cardiac function in a rat model of myocardial infarction (MI). In this study, we investigated the paracrine factors released from h-AECs under hypoxic conditions to elucidate the possible ...
Izarra Alberto A Immunology and Oncology Department, National Center for Biotechnology, CSIC, 28049 Madrid, Spain; Department of Cardiovascular Development and Repair, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, - - 2014
miR-133a and miR-1 are known as muscle-specific microRNAs that are involved in cardiac development and pathophysiology. We have shown that both miR-1 and miR-133a are early and progressively upregulated during in vitro cardiac differentiation of adult cardiac progenitor cells (CPCs), but only miR-133a expression was enhanced under in vitro oxidative stress. miR-1 ...
Lezaic Luka L Department for Nuclear Medicine, UMC Ljubljana, - - 2014
We investigated the effects of intracoronary transplantation of CD34(+) cells on myocardial perfusion in patients with non-ischemic dilated cardiomyopathy (DCM). We enrolled 21 patients with DCM (LVEF <40%, NYHA class III) who underwent peripheral stem cell mobilization with G-CSF. CD34(+) cells were collected via apheresis. Patients underwent myocardial perfusion imaging ...
Fernández-Jiménez Rodrigo R Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Spain; Hospital Universitario Clínico San Carlos, - - 2014
It is widely accepted that after myocardial ischemia/reperfusion edema occurs early in the ischemic zone and persists in stable form for at least 1 week. However, there are no longitudinal studies covering from very early (minutes) to late (one week) reperfusion stages confirming this phenomenon. To perform a comprehensive longitudinal ...
Jiao Qibin Q Department of Cardiology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang Province, - - 2014
No-reflow after reperfusion therapy for myocardial infarction is a strong predictor of clinical outcome. Increased level of inflammatory factors including C-reactive protein (CRP) levels in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) may affect myocardial perfusion. However mechanisms that no-reflow increases in inflammation stress on ...
Li Jingbo J Division of Vascular Surgery, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. - - 2014
It has been previously reported that Toll‑like receptor 4 (TLR4)/NF‑κB signaling mediates early inflammation during myocardial ischemia and reperfusion. It has additionally been suggested that resveratrol produces cardioprotective and anti‑inflammatory effects. The aim of the present study was to investigate whether resveratrol could modulate TLR4/NF‑κB signaling, reduce neutrophil accumulation and TNF‑α ...
Ong S-B SB The Hatter Cardiovascular Institute, University College London, London, - - 2014
Mitochondria have long been known to be the gatekeeper of cell fate. This is particularly so in the response to acute ischaemia-reperfusion injury (IRI). Following an acute episode of sustained myocardial ischaemia, the opening of the mitochondrial permeability transition pore (MPTP) in the first few minutes of reperfusion, mediates cell ...
Thackeray James T JT Department of Nuclear Medicine, Hanover Medical School, Carl Neuberg-Str. 1, 30625, Hanover, - - 2014
Myocardial inflammation is an emerging target for novel therapies and thus for molecular imaging. Positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) has been employed, but requires an approach for suppression of cardiomyocyte uptake. We tested clinically viable strategies for their suitability in mouse models in order to optimize preclinical imaging ...
Michelucci Antonio A Section of Arrhythmology, Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy, - - 2014
The aim of the study was to evaluate the association between circulating (CPCs) and endothelial (EPCs) progenitor cells and left ventricular (LV) remodeling in chronic heart failure (HF). 85 HF patients, ranging 29-89 years, 83.5 % males, 45.9 % ischemic, NYHA functional class II-IV, with a LV ejection fraction ≤40 % were studied. LV ...
Lax Antonio A Cardiology Department, University Hospital Virgen de la Arrixaca, Murcia, Spain; Department of Internal Medicine, School of Medicine, University of Murcia, Murcia, - - 2014
This study aimed to evaluate the specific role of the 2 available MRAs, eplerenone and spironolactone, on the modulation of galectin-3 (Gal-3) and interleukin (IL)-33/ST2 signaling in an experimental model of left ventricular systolic dysfunction after acute MI. The molecular mechanisms of benefits of mineralocorticoid receptor antagonists (MRAs) in patients ...
Theurl Markus M Medical University Innsbruck, University Hospital of Internal Medicine III, Department of Cardiology and - - 2014
Hypercholesterolemia is a major risk factor for cardiovascular diseases and has been shown to influence angiogenesis in the hind limb ischemia (HLI) model. The impaired up-regulation of angiogenic factors seems to be one of the underlying mechanisms for reduced vessel formation. Since we found that secretoneurin (SN) is up-regulated in ...
Latet Sam C SC Cardiovascular Diseases, Department of Translational Pathophysiological Research, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610 Wilrijk, Belgium; Laboratory of Cellular and Molecular Cardiology, Department of Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium. Electronic address: - - 2014
Growing evidence indicates that overactivation and prolongation of the inflammatory response after acute myocardial infarction (AMI) result in worse left ventricular remodelling, dysfunction and progression to heart failure. This post-AMI inflammatory response is characterised by the critical involvement of cells from both the innate and adaptive immune systems. In this ...
Carvalho Luiz Sergio F LS Cardiology Division, State University of Campinas School of Medicine (Unicamp), Campinas, SP, - - 2014
Objective: Recent data suggests that cholesteryl ester transfer protein (CETP) activity may interact with acute stress conditions via inflammatory-oxidative response and thrombogenesis. We investigated this assumption in patients with ST-elevation myocardial infarction (STEMI). Methods: Consecutive patients with STEMI (n = 116) were enrolled <24-h of symptoms onset and were followed for 180 days. ...
Bhaarathy V V Centre for Nanofibers & Nanotechnology, NUSNNI, Faculty of Engineering, National University of Singapore, 117576, Singapore; Department of Nanoscience and Technology, School of Physical Sciences, Bharathiar University, Coimbatore 641046, India; Lee Kong Chian School of Medicine, Nanyang Technological University, 138673, - - 2014
Nanofibrous structure developed by electrospinning technology provides attractive extracellular matrix conditions for the anchorage, migration and differentiation of stem cells, including those responsible for regenerative medicine. Recently, biocomposite nanofibers consisting of two or more polymeric blends are electrospun more tidily in order to obtain scaffolds with desired functional and mechanical ...
Ye Xiaofeng X Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, - - 2014
Scalable units for building cardiac tissue are created from biodegradable elastomeric polymers by L. E. Freed and co-workers on page 7202. The multilayered scaffolds are fabricated by pairwise stacking of heart-cell scaffolds with internal pore architectures and perfusable microvessels with rapidly degrading interfaces. This platform supports viable heart cells in ...
Cabrera-Fuentes H A - - 2014
Despite optimal therapy, the morbidity and mortality of patients presenting with an acute myocardial infarction (MI) remain significant, and the initial mechanistic trigger of myocardial "ischaemia/reperfusion (I/R) injury" remains greatly unexplained. Here we show that factors released from the damaged cardiac tissue itself, in particular extracellular RNA (eRNA) and tumour-necrosis-factor ...
Bonafè Francesca - - 2014
Hyaluronan (HA) is abundantly expressed in several human tissues and a variety of roles for HA has been highlighted. Particularly relevant for tissue repair, HA is actively produced during tissue injury, as widely evidenced in wound healing investigations. In the heart HA is involved in physiological functions, such as cardiac ...
Kim Donghyeon D School of Information and Communication, Gwangju Institute of Science and Technology, Gwangju, Republic of - - 2014
Strokes attributable to subcortical infarcts have been increasing recently in elderly patients. To gain insight how this lesion influences the motor outcome and responds to rehabilitative training, we used circumscribed photothrombotic capsular infarct models on 36 Sprague-Dawley rats (24 experimental and 12 sham-operated). We used 2-deoxy-2-[(18)F]-fluoro-D-glucose-micro positron emission tomography (FDG-microPET) ...
Ishikawa Kiyotake K Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY - - 2014
-Stem cell factor (SCF), a ligand of the c-kit receptor, is a critical cytokine which contributes to cell migration, proliferation, and survival. It has been shown that SCF expression increases after myocardial infarction (MI) and may be involved in cardiac repair. The aim of this study was to determine whether ...
Meng Cong C Department of Radiology, Huangdao Branch of the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266555, P.R. - - 2014
Oxysophoridine (OSR), a natural alkaloid derived from the traditional Chinese medicinal plant sophora alopecuroides, can perform a variety of pharmacological actions. The aim of the present study was to assess the cardioprotective effect of OSR against acute myocardial infarction (AMI) in rats. OSR markedly reduced infarction size and levels of ...
Lv Min M Department of Cardiovascular Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. - - 2014
The role of pterostilbene (Pte) in inflammation induced by ischemia/reperfusion is not well understood. The aim of this study was to investigate whether Pte modulates neutrophil accumulation and the induction of tumor necrosis factor-α (TNF‑α) in an ischemia/reperfusion (I/R)‑injured rat heart model. Rats were randomly exposed to a sham operation, ...
Toldo Stefano S Virginia Commonwealth University, Internal Medicine , 1220 E Broad Street, MMRB room 6040 , 1220 E Broad Street, MMRB room 6040 , Richmond, Virginia, United States, 23298 , 8043988646 ; - - 2014
Significance. An inflammatory response follows an injury of any nature, and while such response is an attempt to promote healing, it may itself result in further injury. Recent Advances. The inflammasome is a macromolecular structure recently recognized as a central mediator in the acute inflammatory response. The inflammasome senses the ...
Iglesias-Garcia Olalla O United States ; - - 2014
Stem cell-derived cardiomyocytes (CMs) are often electrophysiologically immature and heterogeneous, which represents a major barrier to their in vitro and in vivo application. Therefore, the purpose of this study was to examine whether Neuregulin-1b (NRG-1b) treatment could enhance in vitro generation of mature "working-type" CMs from induced pluripotent stem cells ...
Xu Xianyao X Division of Cardiothoracic Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, - - 2014
Cardiac ischemia-reperfusion (I-R) injury remains a significant problem as there are no therapies available to minimize the cell death that can lead to impaired function and heart failure. We have shown that high-molecular-weight polyethylene glycol (PEG) (15-20 kD) can protect cardiac myocytes in vitro from hypoxia-reoxygenation injury. In this study, we ...
Manskikh V N VN Faculty of Bioengineering and Bioinformatics, and Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia. - - 2014
Age-related changes in mammalian hearts often result in cardiac hypertrophy and fibrosis that are preceded by inflammatory infiltration. In this paper, we show that lifelong treatment of BALB/c and C57BL/6 mice with the mitochondria-targeted antioxidant SkQ1 retards senescence-associated myocardial disease (cardiomyopathy), cardiac hypertrophy, and diffuse myocardial fibrosis. To investigate the ...
Jun Ji Hae JH Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of - - 2014
Erythropoietin (EPO), an essential hormone for erythropoiesis, provides protection against myocardial ischemia/reperfusion (I/R) injury. Hyperglycemia during acute myocardial infarction aggravates organ damage and attenuates the efficacies of various protective measures. This study aimed to investigate the protective role of EPO against myocardial I/R injury under a clinically relevant moderate hyperglycemic ...
Fargnoli A S AS Sanger Heart & Vascular Institute, Thoracic and Cardiac Surgery, Cannon Research Center, Carolinas Healthcare System, 1542 Garden Terrace, Charlotte, NC, 28203, - - 2014
This study evaluates needleless liquid jet method and compares it with three common experimental methods: (1) intramuscular injection (IM), (2) left ventricular intracavitary infusion (LVIC), and (3) LV intracavitary infusion with aortic and pulmonary occlusion (LVIC-OCCL). Two protocols were executed. First (n = 24 rats), retention of dye was evaluated 10 min after ...
Hermann Romina R Physiology Unit, Department of Biological Sciences, School of Pharmacy and Biochemistry, University of Buenos Aires and IQUIMEFA-CONICET, Buenos Aires, - - 2014
Although autophagy is a prominent feature of myocardial ischaemia and reperfusion, its functional significance is unclear and controversial. In order to gain a deeper insight into the role of autophagy in myocardial ischaemia-reperfusion, we explored the effects of the pharmacological inhibitor of autophagy 3-methyladenine (3-MA). Isolated rat atria subjected to ...
Fry Christopher H CH School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol, United Kingdom - - 2014
-We tested the hypothesis that alterations to action potential conduction velocity (CV) and conduction anisotropy in left ventricular hypertrophy are associated with topographical changes to gap-junction coupling and intracellular conductance by measuring these variables in the same preparations. -Left ventricular papillary muscles were excised from aortic-banded or sham-operated guinea-pig hearts. ...
Abbate Antonio A VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia. Electronic address: - - 2014
Alpha-1 antitrypsin (AAT) has broad anti-inflammatory and immunomodulating properties in addition to inhibiting serine proteases. Administration of human plasma-derived AAT is protective in models of acute myocardial infarction in mice. The objective of this study was to determine the safety and tolerability of human plasma-derived AAT and its effects on ...
Wang K K Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao 266021, - - 2014
Cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Cell death is a hallmark characteristic of various cardiac diseases, including myocardial infarction and heart failure. Emerging evidences suggest that necrosis is programmed and is one of the main forms of cell death in the pathological process in cardiac ...
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