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Huang Timothy T Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, - - 2014
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is characterized by delay in depolarization of the right ventricle, detected by prolonged terminal activation duration (TAD) in V1-V3. However, manual ECG measurements have shown moderate-to-low intra- and inter-reader agreement. The goal of this study was to assess reproducibility of automated ECG measurements in the ...
Schwartz Jonathan G JG Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford University School of Medicine, Stanford, California, - - 2014
Invasive evaluation and treatment of coronary artery disease (CAD) has traditionally been based upon coronary angiography to determine the need for and the success of revascularization. However, coronary angiography augmented with fractional flow reserve (FFR) creates a paradigm shift, providing a more complete functional assessment of coronary lesions. Measuring FFR ...
De Ferrari Gaetano M GM Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100, Pavia, Italy, - - 2014
Baroreflex sensitivity (BRS) measured several days after myocardial infarction (MI) is a powerful predictor of cardiovascular mortality. No information is available on BRS in the early hours of MI. The possibility to reliably assess BRS in the acute phase of MI and its clinical correlates were evaluated in 45 patients ...
Schaap Jeroen J Department of Cardiology, Amphia Hospital, PO Box 90158, 4800 RK, Breda, The Netherlands Department of Nuclear Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands - - 2014
Hybrid single photon emission computed tomography (SPECT)/coronary computed tomography angiography (CCTA) has only been evaluated for its diagnostic accuracy as a single test in patients suspected of significant coronary artery disease (CAD). Added value of hybrid SPECT/CCTA beyond usual clinical work-up, or use of each of these tests separately, remains ...
Winklhofer Sebastian S Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, - - 2014
To investigate the accuracy of post-mortem diffusion tensor imaging (DTI) for the detection of myocardial infarction (MI) and to demonstrate the feasibility of helix angle (HA) calculation to study remodelling of myofibre architecture. Cardiac DTI was performed in 26 deceased subjects prior to autopsy for medicolegal reasons. Fractional anisotropy (FA) ...
Platts David G DG Department of Echocardiography, The Prince Charles Hospital, Brisbane, Australia; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia; The University of Queensland, Brisbane, - - 2014
Transthoracic echocardiography (TTE) during extra corporeal membrane oxygenation (ECMO) is important but can be technically challenging. Contrast-specific TTE can improve imaging in suboptimal studies. These contrast microspheres are hydrodynamically labile structures. This study assessed the feasibility of contrast echocardiography (CE) during venovenous (VV) ECMO in a validated ovine model. Twenty-four ...
Ismail M M El Demerdash Hospital, Cardiology Department, Faculty of medicine Ain Shams University, Cairo, Egypt - - - 2014
We sought to explore the accuracy of the dobutamine--induced percent change of myocardial deformation indices to detect viability following myocardial infarction. We enrolled 60 consecutive patients presenting for myocardial viability assessment at least 4 weeks following ST--segment--elevation myocardial infarction. Strain (S) and strain rate (SR) were individually measured for all ...
Orde Sam R - - 2014
Speckle tracking echocardiography (STE) is a relatively novel and sensitive method for assessing ventricular function and may unmask myocardial dysfunction not appreciated with conventional echocardiography. The association of ventricular dysfunction and prognosis in sepsis is unclear. We sought to evaluate frequency and prognostic value of biventricular function, assessed by STE ...
Sugiyama Tomoyo T Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan; Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, - - 2014
Tissue prolapse (TP) is sometimes observed after percutaneous coronary intervention (PCI), but its clinical significance remains unclear. We investigated the relationship between TP volume on optical coherence tomography (OCT) after PCI and underlying plaque morphologies and the impact of TP on clinical outcomes. We investigated 178 native coronary lesions with ...
Leone Antonio Maria AM Institute of Cardiology, Catholic University of the Sacred Heart, Rome, - - 2014
Aims: The need of adenosine administration for the achievement of maximal hyperaemia limits the widespread application of fractional flow reserve (FFR) in the real world. We hypothesised that Pd/Pa ratio registered during submaximal reactive hyperaemia induced by conventional non-ionic radiographic contrast medium (contrast medium induced Pd/Pa ratio: CMR) can be ...
Mello Bruno Henrique Gallindo de BH Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, - - 2014
Background: The classification or index of heart failure severity in patients with acute myocardial infarction (AMI) was proposed by Killip and Kimball aiming at assessing the risk of in-hospital death and the potential benefit of specific management of care provided in Coronary Care Units (CCU) during the decade of 60. ...
Bartoli Carlo R CR Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United - - 2014
Background Left ventricular assist device (LVAD) thrombosis is a life-threatening complication that remains a major clinical problem. Consensus diagnostic criteria do not exist. We investigated whether hematologic, echocardiographic, or pump parameters reliably change during LVAD thrombosis. Methods A retrospective analysis of 20 consecutive cases of continuous-flow LVAD thrombosis (Thoratec HeartMate II n = 16, ...
Imola Fabrizio F aCardiology Department, San Giovanni Hospital, Rome, Italy bCentro per la Lotta contro l'Infarto (CLI) Foundation, Rome, Italy cSansavini Foundation, Ravenna, Italy dCentre for Inherited Cardiovascular Diseases, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Policlinico San Matteo, Pavia, - - 2014
Thrombus aspiration is useful in improving myocardial reperfusion in comparison to conventional percutaneous coronary intervention in patients with acute myocardial infarction. Nonetheless, assessment of thrombus aspiration efficacy is lacking. Aim of this study was to quantify by frequency domain optical coherence tomography (OCT) the amount of thrombus removal in patients ...
Rodrigo Sander F SF Department of Cardiology, Leiden University Medical Center, Leiden,The - - 2014
We previously showed that intramyocardial bone marrow cell (BMC) injection in patients with refractory angina and chronic myocardial ischemia improves myocardial perfusion, cardiac function and disease-related complaints. Treatment effect varied between patients, but the predictors of response remain to be identified. Therefore, the aim of the present study was to ...
Schindler Thomas H TH Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: - - 2014
Myocardial perfusion imaging with SPECT/CT or with PET/CT is a mainstay in clinical practice for the diagnostic assessment of downstream, flow-limiting effects of epicardial lesions during hyperemic flows and for risk stratification of patients with known or suspected coronary artery disease (CAD). In patients with multivessel CAD, the relative distribution ...
Soman Prem P Division of Cardiology, University of Pittsburgh, Pittsburgh, PA. Electronic address: - - 2014
Myocardial SPECT using standard procedure for perfusion imaging and phase analysis is a novel approach to left ventricular dyssynchrony assessment. Preliminary data suggest excellent repeatability and potential utility for guiding cardiac resynchronization therapy and elucidating mechanisms.
De Cecco Carlo Nicola CN 1 Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226, 25 Courtenay Dr, Charleston, SC - - 2014
OBJECTIVE. The purpose of this article is to prospectively determine the value of stress dual-energy CT (DECT) myocardial perfusion imaging to coronary CT angiography (CTA) for the assessment of coronary artery disease (CAD) in a high-risk population. SUBJECTS AND METHODS. We prospectively enrolled 29 consecutive patients who were referred for ...
Andersen Mads J MJ Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Department of Cardiology, Aarhus University Hospital, Brendstrupgårdsvej 100, DK-8200 Aarhus N, Aarhus, - - 2014
Recent hemodynamic studies have advanced our understanding of heart failure with preserved ejection fraction (HFpEF). Despite improved pathophysiologic insight, clinical trials have failed to identify an effective treatment for HFpEF. Invasive hemodynamic assessment can diagnose or exclude HFpEF, making it invaluable in understanding the basis of the disease. This article ...
Tu Shengxian S Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: - - 2014
This study sought to present a novel computer model for fast computation of myocardial fractional flow reserve (FFR) and to evaluate it in patients with intermediate coronary stenoses. FFR is an indispensable tool to identify individual coronary stenoses causing ischemia. Calculation of FFR from x-ray angiographic data may increase the ...
Pirich C C Department of Nuclear Medicine and Endocrinology, Paracelsus Medical University Salzburg,Salzburg, Austria - - - 2014
IQ SPECT consists of a new pinhole--like collimator, cardio--centric acquisition, and advanced 3D iterative SPECT reconstruction. to compare diagnostic accuracy and functional parameters obtained with IQ SPECT versus conventional SPECT in patients undergoing myocardial perfusion scintigraphy with adenosine stress and at rest. 80 patients with known or suspected coronary artery ...
Yokokawa Miki M Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, - - 2014
Twelve-lead electrocardiogram (ECG) criteria for epicardial ventricular tachycardia (VT) origins have been described. In patients with structural heart disease, the ability to predict an epicardial origin based on the QRS morphology is limited and has been investigated only for limited regions in the heart. The purpose of this study was ...
Larson Erik R ER The University of Texas at Austin, Department of Electrical Engineering, Austin, - - 2014
Implantable cardioverter defibrillators (ICDs) monitor intracardiac electrocardiograms (EGM) to discriminate between ventricular and supraventricular tachycardias. The incidence of inappropriate shocks remains high due to misclassification of the tachycardia in an otherwise hemodynamically stable individual. Coupling EGMs with an assessment of left ventricular (LV) stroke volume (SV) could help in gauging ...
Schuhbaeck Annika A Department of Cardiology, University of Erlangen, Ulmenweg 18, 91054, Erlangen, Germany, - - 2014
Quantitative measurements of coronary plaque volume may play a role in serial studies to determine disease progression or regression. Our aim was to evaluate the interscan reproducibility of quantitative measurements of coronary plaque volumes using a standardized automated method. Coronary dual source computed tomography angiography (CTA) was performed twice in ...
Berge H M HM Oslo Sports Trauma Research Center, Norwegian School of Sport Sciences, Oslo, - - 2014
Electrocardiogram (ECG) and echocardiography are mandatory in preparticipation cardiac screening in soccer players. Abnormal ECG findings usually require follow-up investigations. The main aim of this study was to compare the prevalence of abnormal ECG findings in male professional soccer players according to European Society of Cardiology's (ESC) recommendations and the ...
Uchiyama Yoshikazu Y Department of Medical Physics, Faculty of Life Science, Kumamoto University, 4-24-1 Kuhonji, Kumamoto, Kumamoto, 862-0976, Japan, - - 2014
Detection of lacunar infarcts is important because their presence indicates an increased risk of severe cerebral infarction. However, accurate identification is often hindered by the difficulty in distinguishing between lacunar infarcts and enlarged Virchow-Robin spaces. Therefore, we developed a computer-aided detection (CAD) scheme for the detection of lacunar infarcts. Although ...
Thapa Pooja P The First Affiliated Hospital of Liaoning Medical College, No. 2, Sec. 5, Renmin Road, Guta District, Jinzhou City, Liaoning Province, People's Republic of - - 2014
To assess the clinical utility of measuring mitral annulus displacement (MAD) by two-dimensional speckle tracking for the rapid evaluation of left ventricular longitudinal systolic function in patients with coronary heart disease (CHD). Left ventricular longitudinal systolic function was evaluated by MAD using speckle tracking echocardiography in 30 healthy volunteers (controls) ...
Trevisi Nicola N Arrhythmia Unit and Electrophysiology Laboratories, Ospedale San Raffaele, Via Olgettina 60, Milan, Italy - - 2014
To assess the efficacy of non-contact mapping for outflow tract premature ventricular contraction (PVC) and ventricular tachycardia (VT) ablation in patients without structural heart disease and a precordial transition at V3 or later and to determine the diagnostic accuracy of new virtual unipolar electrogram criteria for distinguishing left from right-sided ...
Radunski Ulf K UK University Heart Center, General and Interventional Cardiology, University Medical Center Hamburg-Eppendorf, Hamburg, - - 2014
We evaluated the accuracy of T2, T1, and extracellular volume (ECV) quantification as novel quantitative tissue markers in comparison with standard "Lake-Louise" cardiac magnetic resonance (CMR) criteria to diagnose myocarditis. Novel approaches using T2 and T1 mapping may overcome the limitations of signal intensity-based parameters, which would potentially result in ...
Vaes Bert - - 2014
Atrial fibrillation is very common in people aged 65 or older. This condition increases the risk of death, congestive heart failure and thromboembolic conditions. Many patients with atrial fibrillation are asymptomatic and a cerebrovascular accident (CVA) is often the first clinical presentation. Guidelines concerning the prevention of CVA recommend monitoring ...
Rautaharju Pentti M PM Epidemiological Cardiology Research Center (EPICARE), Division of Public Health Sciences, Wake Forrest School of Medicine, Winston-Salem, NC, USA. Electronic address: - - 2014
This review covers selected electrocardiographic left ventricular hypertrophy (ECG-LVH) studies which have evaluated their prognostic value for adverse cardiovascular (CVD) events. Most ECG-LVH studies have used echocardiographic left ventricular mass (Echo-LVM) as the gold standard for evaluating ECG-LVH criteria. More recently, LVM from magnetic resonance imaging (MRI-LVM) has evolved as ...
Vardi Moshe M Harvard Clinical Research Institute, Boston, Massachusetts; Department of Biostatistics, Boston University, Boston, Massachusetts. Electronic address: - - 2014
Differences in enrollment criteria and protocol requirements are believed to affect patient representation and outcomes from premarket and postmarket surveillance (PMS) trials. These differences have not been assessed in studies evaluating coronary stenting. We aimed to assess differences in clinical profile and long-term outcomes in patients enrolled into premarket versus PMS ...
Cuesta Pedro P Department of Computer Science. ESEI. University of Vigo. Campus As Lagoas, 32004 Ourense, - - 2014
Premature ventricular contractions (PVCs) are cardiac abnormalities that may occur in subjects with/without cardiovascular disorder. Detection is usually performed from electrocardiograms (ECGs); heart activity for a long period of time must be recorded at hospital or with ambulatory electrocardiography. An alternative with a common mobile device would be very interesting, ...
Migliorini M M Matteo Migliorini, Department of Electronics, Informatics and Bioengineering, Politecnico di Milano, Via Golgi 39, 20133 Milano, Italy, E-mail: - - 2014
Introduction: This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Advanced Methods for Studying Cardiovascular and Respiratory Systems". Objectives: The aim of this study is to assess the reliability of the estimated Nocturnal Heart Rate (HR), recorded through a bed sensor, compared ...
Chow Shien S *The Christie NHS Foundation Trusts †The University of Manchester ‡University Hospital of South Manchester, Manchester, - - 2014
High-dose interleukin 2 (HD-IL2) is one of the therapeutic options for patients with metastatic renal cell carcinoma. In well-selected patients with favorable clinical and pathologic features, it offers impressive response and potential long-term remission. It also has a place for treatment for metastatic malignant melanoma and in adoptive cell therapy. ...
Hatipoğlu Filiz F Department of Nuclear Medicine, Afyon Kocatepe University Faculty of Medicine, Afyonkarahisar, Turkey. - - 2014
Objectives: In this study, we investigated the reliability of gated myocardial perfusion single-photon emission computerized tomography (GSPECT) for the evaluation of left ventricle (LV) function. We compared left ventricle ejection fraction (LVEF) calculated with GSPECT with the values derived from planar equilibrium-gated radionuclide ventriculography (ERVG) and echocardiography (ECHO). Study design: ...
Pavitt Chris W CW Royal Brompton and Harefield NHS - - 2014
CT coronary angiography, Coronary calcium score, NICE guidelines INTRODUCTION: Current UK NICE guidelines recommend an initial CACS scan as a first line investigation in the assessment of patients with stable chest pain with a low pre-test probability of underlying coronary artery disease (CAD), with subsequent evaluation of the coronary tree ...
Gonzalez-Gonzalez Ana M AM Royal Brompton - - 2014
The prognostic value of myocardial perfusion (MP), assessed during stress echocardiography (SE) by myocardial contrast echocardiography (MCE), has been shown in research studies but is untested in a 'real-world' clinical SE service. Patients clinically referred for SE undergoing pharmacological stress, and those doing exercise stress in whom we suspected target ...
Khan Jamal J University of - - 2014
There is no consensus on the optimal method of quantifying infarct size (IS) on late gadolinium imaging (LGE) or area at risk (oedema, [AAR]) on T2-weighted STIR (T2wSTIR) in patients with ST-segment elevation myocardial infarction (STEMI).Semi-automated standard deviation (SD) based techniques, manual contouring of enhancement, and full-width half-maximum (FWHM) methods ...
Greenwood John J Multidisciplinary Cardiovascular Research Centre Leeds - - 2014
CE-MARC was the largest prospective evaluation of the diagnostic accuracy of CMR in coronary artery disease. CE-MARC adopted a multi-parametric protocol assessing ventricular function, myocardial perfusion, viability (with late gadolinium enhancement (LGE)) and coronary artery anatomy. Previous small studies have shown the diagnostic accuracy of different components of the CMR ...
Watkins Stuart S Golden Jubilee - - 2014
Myocardial fractional flow reserve (FFR) has uncertain validity in patients with recent myocardial infarction and the use of FFR in this setting is controversial. We performed a prospective study to assess the diagnostic accuracy of FFR in patients with a recent non-ST segment myocardial infarction (NSTEMI). NSTEMI patients who had ...
Morley-Smith Andrew A Imperial College London and Royal - - 2014
There are few non-invasive techniques to predict and monitor patients' responses to left ventricular assist device (LVAD) therapy. MicroRNAs (miRs) are small noncoding RNAs with intricate roles in cardiovascular disease. They remain stable in the circulation, are readily quantified, and may be useful as new biomarkers. This study sought to ...
Puntmann Valentina V King's College - - 2014
T1 and T2 mapping detect myocardial fibrosis and oedema respectively. T1 values show segmental variation in mid ventricular SAX slice, making the identification of regional pathology difficult.We tested the reproducibility of T1 and T2 mapping in health and disease and regional variations of T2 values. Patients with non-ischaemic cardiomyopathy (NICM, ...
Anthony David D Memorial Hospital of Rhode Island, 111 Brewster St, Pawtucket, RI 02903, - - 2014
Patients with acute chest pain should be assessed first for the likelihood of acute coronary syndrome using the Thrombolysis in Myocardial Infarction score or the Agency for Health Care Policy and Research criteria. If assessment indicates high risk, the patient should be admitted to the hospital. Low- and intermediate-risk patients ...
Udell Jacob A JA Women's College Research Institute and Cardiovascular Division, Department of Medicine, Women's College Hospital, University of Toronto, Toronto, Ontario, - - 2014
This study sought to evaluate the efficacy of prasugrel versus clopidogrel in ST-segment elevation myocardial infarction (STEMI) by the timing of percutaneous coronary intervention (PCI). Treatment strategies and outcomes for patients with STEMI may differ when treated with primary compared with secondary PCI. STEMI patients in the TRITON-TIMI 38 (Trial ...
Seo Yoshihiro Y Cardiovascular Division, Faculty of Clinical Medicine, University of Tsukuba, Tsukuba, - - 2014
Cardiac function analysis is the main focus of echocardiography. Left ventricular ejection fraction (LVEF) has been the clinical standard, however, LVEF is not enough to investigate myocardial function. For the last decade, speckle tracking echocardiography (STE) has been the novel clinical tool for regional and global myocardial function analysis. However, ...
Dercle Laurent L Department of Nuclear Medicine, Toulouse University Hospital, 1, Avenue Jean Poulhès TSA 50032, 31059, Toulouse Cedex 9, France, - - 2014
The assessment of right ventricular function is crucial for management of heart disease. TOMPOOL is a software that processes data acquired with Tomographic Equilibrium Radionuclide Ventriculography. In this report, TOMPOOL's diagnostic accuracy and inter-observer reproducibility were assessed in a cohort of patients with various etiologies of ventricular dysfunction. End-diastolic volume ...
Sato Akira A Akira Sato, Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8577, - - 2014
Coronary computed tomography angiography (CTA) has become the useful noninvasive imaging modality alternative to the invasive coronary angiography for detecting coronary artery stenoses in patients with suspected coronary artery disease (CAD). With the development of technical aspects of coronary CTA, clinical practice and research are increasingly shifting toward defining the ...
Meneveau Nicolas N Department of Cardiology, EA3920, University Hospital Jean Minjoz, 25000 Besançon, France. Electronic address: - - 2014
To date, no randomized study has investigated the value of optical coherence tomography (OCT) in optimizing the results of coronary angioplasty for non-ST-segment elevation acute coronary syndromes. DOCTORS is a randomized, prospective, multicenter, open-label clinical trial to evaluate the utility of OCT to optimize results of angioplasty of a lesion ...
Harada Haruhito H Department of Cardiology, Kurume University Medical Center, 155-1, Kokubu-machi, Kurume, 839-0863, Japan, - - 2014
We assessed the effects of long-term laronidase replacement therapy (LRT) on the left ventricular (LV) function of a 52-year-old adult woman with mucopolysaccharidosis I (MPS I). The urinary uronic acid concentration significantly decreased by 78.7% (from 75 to 16 mg/g creatinine) after LRT; thereafter, estimated LV weight as assessed by two-dimensional ...
Meinel Felix G FG 1 Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, MSC 226, Charleston, SC - - 2014
OBJECTIVE. The purpose of this study was to determine the feasibility of global quantitative measurements of left ventricular myocardial perfusion derived from stress dynamic CT myocardial perfusion imaging. MATERIALS AND METHODS. The coronary CT angiographic and CT myocardial perfusion imaging datasets of 146 patients were visually evaluated for the presence ...
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