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Bhaarathy V V Centre for Nanofibers & Nanotechnology, NUSNNI, Faculty of Engineering, National University of Singapore, 117576, Singapore; Department of Nanoscience and Technology, School of Physical Sciences, Bharathiar University, Coimbatore 641046, India; Lee Kong Chian School of Medicine, Nanyang Technological University, 138673, - - 2014
Nanofibrous structure developed by electrospinning technology provides attractive extracellular matrix conditions for the anchorage, migration and differentiation of stem cells, including those responsible for regenerative medicine. Recently, biocomposite nanofibers consisting of two or more polymeric blends are electrospun more tidily in order to obtain scaffolds with desired functional and mechanical ...
Toldo Stefano S Virginia Commonwealth University, Internal Medicine , 1220 E Broad Street, MMRB room 6040 , 1220 E Broad Street, MMRB room 6040 , Richmond, Virginia, United States, 23298 , 8043988646 ; - - 2014
Significance. An inflammatory response follows an injury of any nature, and while such response is an attempt to promote healing, it may itself result in further injury. Recent Advances. The inflammasome is a macromolecular structure recently recognized as a central mediator in the acute inflammatory response. The inflammasome senses the ...
Iglesias-Garcia Olalla O United States ; - - 2014
Stem cell-derived cardiomyocytes (CMs) are often electrophysiologically immature and heterogeneous, which represents a major barrier to their in vitro and in vivo application. Therefore, the purpose of this study was to examine whether Neuregulin-1b (NRG-1b) treatment could enhance in vitro generation of mature "working-type" CMs from induced pluripotent stem cells ...
Manskikh V N VN Faculty of Bioengineering and Bioinformatics, and Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia. - - 2014
Age-related changes in mammalian hearts often result in cardiac hypertrophy and fibrosis that are preceded by inflammatory infiltration. In this paper, we show that lifelong treatment of BALB/c and C57BL/6 mice with the mitochondria-targeted antioxidant SkQ1 retards senescence-associated myocardial disease (cardiomyopathy), cardiac hypertrophy, and diffuse myocardial fibrosis. To investigate the ...
Fargnoli A S AS Sanger Heart & Vascular Institute, Thoracic and Cardiac Surgery, Cannon Research Center, Carolinas Healthcare System, 1542 Garden Terrace, Charlotte, NC, 28203, - - 2014
This study evaluates needleless liquid jet method and compares it with three common experimental methods: (1) intramuscular injection (IM), (2) left ventricular intracavitary infusion (LVIC), and (3) LV intracavitary infusion with aortic and pulmonary occlusion (LVIC-OCCL). Two protocols were executed. First (n = 24 rats), retention of dye was evaluated 10 min after ...
Hermann Romina R Physiology Unit, Department of Biological Sciences, School of Pharmacy and Biochemistry, University of Buenos Aires and IQUIMEFA-CONICET, Buenos Aires, - - 2014
Although autophagy is a prominent feature of myocardial ischaemia and reperfusion, its functional significance is unclear and controversial. In order to gain a deeper insight into the role of autophagy in myocardial ischaemia-reperfusion, we explored the effects of the pharmacological inhibitor of autophagy 3-methyladenine (3-MA). Isolated rat atria subjected to ...
Fry Christopher H CH School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol, United Kingdom - - 2014
-We tested the hypothesis that alterations to action potential conduction velocity (CV) and conduction anisotropy in left ventricular hypertrophy are associated with topographical changes to gap-junction coupling and intracellular conductance by measuring these variables in the same preparations. -Left ventricular papillary muscles were excised from aortic-banded or sham-operated guinea-pig hearts. ...
Wang K K Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao 266021, - - 2014
Cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Cell death is a hallmark characteristic of various cardiac diseases, including myocardial infarction and heart failure. Emerging evidences suggest that necrosis is programmed and is one of the main forms of cell death in the pathological process in cardiac ...
Talbert Dominique R DR Quintiles Inc., Translational R&D - Oncology , 777 Oakmont Lane Suite #100, Westmont, IL 60559 - - 2014
Ponatinib, a multi-targeted TKI and potent pan-ABL inhibitor, approved for the treatment of Ph+ALL and CML, was temporarily withdrawn from the US market due to severe vascular adverse events. Cardiac-specific toxicities including myocardial infarction, severe congestive heart failure, and cardiac arrhythmias have also been shown with ponatinib. Targeted oncology agents ...
He Ke K Integration of Traditional Chinese and Western Medicine, School of Basic Medical Sciences, Peking - - 2014
Cardiac ischemia-reperfusion (I/R) injury remains a challenge for clinicians, which initiates with energy metabolism disorder. The present study was designed to investigate the protective effect of Notoginsenoside R1 (NR1) on I/R-induced cardiac injury and underlying mechanism. Male Sprague-Dawley rats were subjected to 30 min occlusion of left coronary anterior descending ...
Wang Qiang Q Department of Anesthesiology, Peking University People's Hospital, Beijing, China, - - 2014
To determine the optimal intervention time of the vagal stimulation (VS) attenuating myocardial ischemia/reperfusion injury (IRI). One hundred and twenty male SD rats were randomly allocated into six groups: sham group, IRI group, the VS performed at 15 min of ischemia (VSI15) group, the VS performed immediately before reperfusion (VSR0) group, ...
Rengarajan Balaji B Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, 401 Smyth Rd, Ottawa, Ontario, K1H 8L1, - - 2014
Spinal cord infarction is extremely rare in childhood and can result from a wide range of causes. Fibrocartilaginous embolism can give rise to spinal stroke and mimic non-vascular disease such as acute transverse myelitis. We report two children who suffered an asymmetrical spinal cord infarction due to fibrocartilaginous embolism. The ...
Inserte Javier J Laboratory of Experimental Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Barcelona, - - 2014
Cardiomyocyte cell death occurring during myocardial reperfusion (reperfusion injury) contributes to final infarct size after transient coronary occlusion. Different interrelated mechanisms of reperfusion injury have been identified, including alterations in cytosolic Ca(2+) handling, sarcoplasmic reticulum-mediated Ca(2+) oscillations and hypercontracture, proteolysis secondary to calpain activation, and mitochondrial permeability transition. All these ...
de Jong Renate R From the Department of Cardiology, Thorax Center, Erasmus University Medical Center, Rotterdam, The Netherlands (R.d.J., J.H.H., K.K.); Experimental Cardiology Laboratory, University and Medical Center Utrecht, The Netherlands (G.P.J.v.H., G.P., I.E.H.); BTG International Germany GmbH, Alzenau, Germany (C.W.); Biocompatibles UK Ltd, a BTG International Group Company, Farnham, United Kingdom (A.L.); and Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands - - 2014
Engraftment and survival of stem cells in the infarcted myocardium remain problematic in cell-based therapy for cardiovascular disease. To overcome these issues, encapsulated mesenchymal stem cells (eMSCs) were developed that were transfected to produce glucagon-like peptide-1, an incretin hormone with known cardioprotective effects, alongside MSC endogenous paracrine factors. This study ...
De Jesus Nicole M NM Department of Pharmacology, University of California, Davis, School of Medicine, Davis, CA; Department of Biomedical Engineering, University of California, Davis, School of Engineering; Davis, - - 2014
Atherosclerotic animal models show increased recruitment of inflammatory cells to the heart following myocardial infarction (MI), which impacts ventricular function and remodeling. To determine whether increased myocardial inflammation following MI also contributes to arrhythmias. MI was created in 3 mouse models: 1) atherosclerotic (ApoE(-/-) on atherogenic diet; n=12), 2) acute ...
Yoshikawa Noritada N Department of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Electronic address: - - 2014
Pulmonary hypertension (PH) sustains elevation of pulmonary vascular resistance and ultimately leads to right ventricular (RV) hypertrophy and failure and death. Recently, proangiogenic factors hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) have been known to promote left ventricular myocardial angiogenesis and lead to cardiac hypertrophy, and this ...
Conklin John J Department of Medical Imaging, University of Toronto, Toronto, - - 2014
Neuroimaging of older adults commonly reveals abnormality (leukoaraiosis) in the cerebral white matter. Studies have established that extensive leukoaraiosis predicts dementia and disability, but the pathogenesis of leukoaraiosis remains unclear. We recruited five patients with leukoaraiosis and performed magnetic resonance mapping of the brain for 16 consecutive weeks. We observed ...
Abe Yuzuru Y Department of Cardiovascular Medicine, Tohoku University Graduate School of - - 2014
Background:It has been previously demonstrated that extracorporeal low-energy shock-wave (SW) therapy ameliorates left ventricular (LV) remodeling through enhanced angiogenesis after acute myocardial infarction (AMI) in pigs in vivo. However, it remains to be examined whether SW therapy also exerts anti-inflammatory effects on AMI.Methods and Results:AMI was created by ligating the proximal left ...
Hassan Quamrul Q Research Scholar, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, - - 2014
Abstract Objective: The effects of benidipine on oxidative stress and myocardial apoptosis were assessed in isoproterenol (ISO) induced myocardial infarction (MI) in wistar rats. Material Method: Animals were pretreated with benidipine (1, 3, 10 μg/kg/day Body weight) intravenously for a period of 28 days. After pretreatment, ISO (85 mg/kg Body ...
Alam M R MR INSERM U1060, CarMeN Laboratory, Claude Bernard Lyon 1 University, F-69373 Lyon, - - 2014
Reperfusion is characterized by a deregulation of ion homeostasis and generation of reactive oxygen species that enhance the ischemia-related tissue damage culminating in cell death. The mitochondrial permeability transition pore (mPTP) has been established as an important mediator of ischemia-reperfusion (IR)-induced necrotic cell death. Although a handful of proteins have ...
Bleilevens C C Department of Anesthesiology, University Hospital Aachen, Pauwelsstrasse 30, 52074, Aachen, - - 2014
Cerebral injuries can trigger stress-related cardiomyopathy. The extent of cerebral injury and the involvement of the insular cortex influence the incidence and extent of myocardial injury (MI), and drugs with proven neuroprotective and cardioprotective properties such as levosimendan might be beneficial. This hypothesis was addressed in a rat model of ...
Zhu Gang-Jie GJ Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, - - 2014
The aim of this study was to explore myocardial protection of early extracorporeal membrane oxygenation (ECMO) support for acute myocardial infarction with cardiogenic shock in pigs. 24 male pigs (34.6 ± 1.3 kg) were randomly divided into three groups-control group, drug therapy group, and ECMO group. Myocardial infarction model was created in drug ...
Boštjančič Emanuela E Emanuela Boštjančič, Damjan Glavač, Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, - - 2014
MicroRNAs (miRNAs), which are small and non-coding RNAs, are genome encoded from viruses to humans. They contribute to various developmental, physiological and pathological processes in living organisms. A huge amount of research results revealed that miRNAs regulate these processes also in the heart. miRNAs may have cell-type-specific or tissue-specific expression ...
Jiang Miaomiao - - 2014
Metabonomics is a useful tool for studying mechanisms of drug treatment using systematic metabolite profiles. Ginsenosides Rg1 and Rb1, ophiopogonin D, and schizandrin are the main bioactive components of a traditional Chinese formula (Sheng-Mai San) widely used for the treatment of coronary heart disease. It remains unknown the effect of ...
Kostić Jelena J Institute of Histology and Embryology "Aleksandar Đ. Kostić", School of Medicine, University of Belgrade, Višegradska 26, 11000 Belgrade, Serbia. Electronic address: - - 2014
Coronary artery thrombosis in ST-elevation myocardial infarction (STEMI) is a dynamic process often preceded by episodes of silent plaque rupture and subocclusive thrombosis. Thrombus organization is achieved by ingrowth of endothelial and smooth muscle cells. Clinical significance and impact of thrombus neovascularization on primary percutaneous coronary intervention (pPCI) outcome remain ...
Takematsu M M Division of Medical Toxicology, Department of Emergency Medicine, Montefiore Medical Center, Albert Einstein College of Medicine , New York, NY , - - 2014
Objective. Synthetic cannabinoids are increasingly used in the United States as marijuana substitutes. However, reports of severe toxicity, resulting from their use, are limited. We present the case of acute cerebral infarction following synthetic cannabinoid inhalation. Case report. A 33-year-old man with no significant medical history presented at the emergency ...
Haar Lauren L Shriners Hospital for Children and University of - - 2014
Previous studies have demonstrated improvement of cardiac function occurs with acute consumption high fat diet (HFD) after myocardial infarction (MI). However, no data exists addressing the effects of acute HFD upon the extent of injury after MI. This study investigates the hypothesis that short term HFD, prior to infarction, protects ...
Ye Xiaofeng X Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, - - 2014
Scalable units for building cardiac tissue are fabricated from biodegradable elastomeric polymers by pairwise stacking of heart cell scaffolds with sinusoidal internal pore architectures and dedicated perfusable microvessels with rapidly degrading porous interfaces in a parallel flow configuration. This platform supports viable heart cells in vitro and, if validated in ...
Ballas Samir K SK Cardeza Foundation for Hematologic Research, Department of Medicine, Jefferson Medical College, Thomas Jefferson University , Philadelphia, Pennsylvania , USA - - 2014
Abstract The most common cause of stroke in children with sickle cell anemia is infarction due to ischemia. In adults, however, stroke is most commonly hemorrhagic in nature. Other causes of stroke in patients with sickle cell disease are very rare. In this short communication, we describe a woman with ...
Castro-Ferreira Ricardo R Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, - - 2014
The myocardial response to acute stretch consists of a two-phase increase in contractility: an acute increase by the Frank-Starling mechanism and a gradual and time-dependent increase in force generated known as the slow force response (SFR). The SFR is actively modulated by different signaling pathways, but the role of protein ...
Li Zhiyuan Z Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China; Department of Cardiology, Shandong Provincial Taishan Hospital, Tai'an, Shandong, - - 2014
The neural remodeling of the atrium plays an important role in the initiation of atrial fibrillation after myocardial infarction (MI); however, the effects of the left stellate ganglion (LSG) on the neural remodeling of the atrium remain incompletely understood. Thus, this study investigated the mechanism by which the LSG mediates ...
Agnić Ivan I Department of Anesthesiology, University Hospital Split, Split, Croatia. Electronic address: - - 2014
The application of isoflurane in a postconditioning manner, during early reperfusion of ischemic myocardium, reduces the infarct size. Its favorable effect on highly vascularized granulation tissue formation is very important considering the fact that increased genesis of blood vessels in peri-infarct zone reduces the infarct size and improves cardiac function. ...
Wan Chunxiao C , Rehabilitation Medicine Centre, Chinese PLA General Hospital, , - - 2014
Objective: To locate and trace endogenous endothelial progenitor cells (EPCs) in rabbits subjected to myocardial ischaemia and/or physiological ischaemia training. Methods: Rabbits were randomly divided into 4 groups: a myocardial ischaemia group (subjected to myocardial ischaemia only); a physiological ischaemia training group (subjected to physiological ischaemia training only); a physiological ...
Ramaiola Ilaria I Cardiovascular Research Center (CSIC-ICCC), IIB SantPau, c/Sant Antoni Mª Claret 167, 08025 Barcelona, - - 2014
Thrombus formation is a dynamic process regulated by flow, blood cells, and plasma proteins. The present study was performed to investigate the characteristics of human coronary thrombus in ST-segment elevation myocardial infarction (STEMI). Patients admitted with ST-elevation myocardial infarction, in which thrombectomy was performed, were included (n = 86). Intracoronary ...
Cohen Michael V MV From the Departments of Physiology University of South Alabama College of Medicine, Mobile, AL; From the Departments of Medicine, University of South Alabama College of Medicine, Mobile, - - 2014
Ischemic pre- and postconditioning are potent cardioprotective interventions that spare ischemic myocardium and decrease infarct size after periods of myocardial ischemia/reperfusion. They are dependent on complex signaling pathways involving ligands released from ischemic myocardium, G-protein-linked receptors, membrane growth factor receptors, phospholipids, signaling kinases, nitric oxide, protein kinase C and G, ...
Shen Yaqi Y Fudan University, School of Pharmacy, Department of Pharmacology, Shanghai, China ; - - 2014
Aims: Myocardial infarction (MI) is a leading cause of death globally. MicroRNAs have been identified as a novel class of MI injury regulators. Hydrogen sulfide (H2S) is a gaseous signaling molecule that regulates cardiovascular function. The purpose of this study was to explore the role of the miR-30 family in ...
Todica Andrei A Department of Nuclear Medicine, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, - - 2014
Several studies substantiate the cardioprotective effects of erythropoietin (EPO). Our goal was to quantify the effects of EPO treatment on the early expression of the apoptosis marker phosphatidylserine as well as on the left ventricular volumes and function by means of small animal PET. Myocardial infarction (MI) was induced in ...
Weinreuter Martin M Research Unit Cardiac Epigenetics, Department of Cardiology, University of Heidelberg, Heidelberg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, - - 2014
CaMKII was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. Here, we investigated the roles of different CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury by the use of new genetic CaMKII mouse models. Although CaMKIIδC was upregulated 1 day after I/R injury, cardiac damage 1 day after I/R ...
Wang Ping P Department of heart center Capital Medical University Affiliated Beijing Friendship - - 2014
Aims: Recently, a number of studies have shown an increased red blood cell distribution width (RDW) to be a strong and independent predictor of the prognosis of coronary artery disease. The aim of this study was to investigate the underlying mechanisms responsible for the relationship between the RDW and a ...
Polk Anne - - 2014
Cardiotoxicity is a serious side effect to treatment with 5-fluorouracil (5-FU), but the underlying mechanisms are not fully understood. The objective of this systematic review was to evaluate the pathophysiology of 5-FU- induced cardiotoxicity. We systematically searched PubMed for articles in English using the search terms: 5-FU OR 5-fluorouracil OR ...
Huang Timothy T Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, - - 2014
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is characterized by delay in depolarization of the right ventricle, detected by prolonged terminal activation duration (TAD) in V1-V3. However, manual ECG measurements have shown moderate-to-low intra- and inter-reader agreement. The goal of this study was to assess reproducibility of automated ECG measurements in the ...
Schwartz Jonathan G JG Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford University School of Medicine, Stanford, California, - - 2014
Invasive evaluation and treatment of coronary artery disease (CAD) has traditionally been based upon coronary angiography to determine the need for and the success of revascularization. However, coronary angiography augmented with fractional flow reserve (FFR) creates a paradigm shift, providing a more complete functional assessment of coronary lesions. Measuring FFR ...
Shevach Michal - - 2014
Decellularized matrices are valuable scaffolds for engineering functional cardiac patches for treating myocardial infarction. However, the lack of quick and efficient electrical coupling between adjacent cells may jeopardize the success of the treatment. To address this issue, we have deposited gold nanoparticles on fibrous decellularized omental matrices and investigated their ...
Wang Zhengbin Z Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, - - 2014
This paper introduces the research progress related to the antioxidant activity of bamboo leaf flavonoid (EOB-f) and its pharmacological activity of heart and cerebral vessels. The paper studied what role EOB-f played in the diagnosis of heart and cerebral vessels, based on the in vitro, in vivo and animal model ...
Luo Xiu-Ju - - 2014
Mitochondrial aldehyde dehydrogenase (ALDH2) is an isoenzyme of aldehyde dehydrogenases (ALDH), a group of enzymes that are responsible for clearance of aldehydes in the body. In animal myocardial or cerebral ischemia/reperfusion (I/R) models, accumulation of toxic aldehydes, such as 4-hydroxy-2-nonenal and malondialdehyde, is thought to be an important mechanism for ...
Wang Huishu H Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, China Affiliated Union Hospital, Fujian Medical University, - - 2014
Pharmacological preconditioning limits myocardial infarct size after ischemia/reperfusion. Dexmedetomidine is an α2-adrenergic receptor agonist used in anesthesia that may have cardioprotective properties against ischemia/reperfusion injury. We investigated whether dexmedetomidine induces cardioprotection against myocardial apoptosis injury. In order to assess the role of dexmedetomidine on myocardial apoptosis, we established a grave ...
Hastings Conn L CL Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephens Green, Dublin 2, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin (TCD), College Green, Dublin 2, Ireland; Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI & TCD, Dublin 2, - - 2014
The spectrum of ischemic cardiomyopathy, encompassing acute myocardial infarction to congestive heart failure is a significant clinical issue in the modern era. This group of diseases is an enormous source of morbidity and mortality and underlies significant healthcare costs worldwide. Cardiac regenerative therapy, whereby pro-regenerative cells, drugs or growth factors ...
Zhang Yan Y Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, - - 2014
This study aimed to investigate whether interferon regulatory factor 9 (IRF9) is involved in the pathogenesis of myocardial ischemia-reperfusion (I/R) injury and to explore the underlying molecular mechanisms of this process. Cell death plays a major role in myocardial I/R injury. We recently determined the importance of IRF9 in coordinating ...
Al-Amran Fadhil G FG Department of Surgery, Kufa University, Najaf, - - 2014
Background: Myocardial infarction is accompanied by inflammatory responses that lead to the recruitment of leukocytes and subsequent myocardial damage and healing. Monocyte chemoattractant protein-1 (MCP-1, also known as CC chemokine ligand 2) and its receptor CC chemokine receptor 2 play a central role in the inflammatory response and myocardial injury ...
Shimkunas Rafael R - - 2014
After myocardial infarction, a poorly contracting non-ischemic border zone forms adjacent to the infarct. The cause of border zone dysfunction is unclear. The goal of this study was to determine the myofilament mechanisms involved in post-infarction border zone dysfunction. Two weeks after anteroapical infarction of sheep hearts, we studied in-vitro ...
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