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Results 201 - 250 of 969
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Estep Jerry D JD Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas. Electronic address: - - 2014
Malfunction of a continuous-flow left ventricular assist device (CF-LVAD) due to device thrombosis is a potentially life-threatening event that currently presents a diagnostic challenge. We aimed to propose a practical echocardiographic assessment to diagnose LVAD malfunction secondary to pump thrombosis. Among 52 patients implanted with a CF-LVAD from a single ...
Gaggin Hanna K HK Division of Cardiology, Massachusetts General Hospital, Boston, - - 2014
This analysis aimed to perform a head-to-head comparison of 3 of the promising biomarkers of cardiovascular (CV) outcomes in heart failure (HF)-soluble ST2 (sST2), growth differentiation factor (GDF)-15, and highly-sensitive troponin T (hsTnT)-and to evaluate the role of serial measurement of these biomarkers in patients with chronic HF. sST2, GDF-15, ...
Perfetti Matteo M Institute of Cardiology, "G. d'Annunzio" University, Chieti, Pescara, - - 2014
Current cardiac magnetic resonance (CMR) quantitative signs for the diagnosis of myocarditis include myocardial edema, fibrosis and myocardial hyperemia (Hyp). Methods for the assessment of Hyp are actually complex and time-consuming. To test a simple and fast method to assess Hyp, using contrast enhancement steady state free precession (ceSSFP) technique. ...
Nørgaard Bjarne L BL Department of Cardiology, Aarhus University Hospital Skejby, Aarhus, Denmark. Electronic address: - - 2014
To determine the diagnostic performance of non-invasive FFR derived from standard acquired coronary computed tomography angiography (CTA) datasets (FFRCT) for the diagnosis of myocardial ischemia in patients with suspected stable coronary artery disease (CAD). Fractional flow reserve (FFR) measured during invasive coronary angiography (ICA) is the gold standard for lesion-specific ...
Lux Robert L RL Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States of - - 2014
Precise measurement of the QT interval is often hampered by difficulty determining the end of the low amplitude T wave. Root mean square electrocardiography (RMS ECG) provides a novel alternative measure of ventricular repolarization. Experimental data have shown that the interval between the RMS ECG QRS and T wave peaks ...
Yildiz Abdulkadir - - 2014
The aim of the study was to evaluate the utility of the preprocedural platelet-lymphocyte ratio (PLR) for predicting no reflow in patients undergoing primary percutaneous intervention (PCI) for the treatment of ST-segment elevation myocardial infarction. The thrombolysis in myocardial infarction (TIMI) flow grades of 287 patients treated with primary PCI ...
Vardi Moshe - - 2014
Atherosclerosis and venous thromboembolism (VTE) share common risk factors. We set to assess the strength of the association between atherosclerosis risk factors and disease manifestation, and VTE, in patients with coronary artery disease undergoing percutaneous coronary intervention. We pooled data from 6 global randomized controlled trials assessing coronary stenting (ENDEAVOR ...
Yildirim Erkan - - 2014
Urocortin 1 (UCN1) has cardiostimulatory, vasodilator, diuretic and natriuretic effects and its expression increases in heart failure (HF). The aim of the study was to determine UCN1 levels in patients with HF, to evaluate UCN1's relationship with various clinical parameters and to assess UCN1 as a diagnostic marker in HF, ...
Joutsiniemi Esa E Heart Center, Turku University Hospital, Turku, - - 2014
We compared the accuracy of quantified myocardial flow reserve and absolute stress myocardial blood flow (MBF) alone in the detection of coronary artery disease (CAD). Myocardial flow reserve, i.e. ratio of stress and rest flow, has been commonly used to detect CAD with many imaging modalities. However, it is not ...
Hoey E T D ET Department of Radiology, Heart of England NHS Foundation Trust, Birmingham, West Midlands, UK. Electronic address: - - 2014
Hypertrophic cardiomyopathy (HCM) is the most common inheritable cardiovascular disorder. Although many HCM patients remain asymptomatic, sudden death (SD) can occur as the initial manifestation of the disease. It has been hypothesized that myocardial architectural disorganization and scarring represent an unstable electrophysiological substrate that creates susceptibility to malignant ventricular arrhythmias. ...
Ebrille Elisa E Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, - - 2014
Outflow tract ventricular arrhythmia (OTVA) can be complicated to target for ablation when originating from either the periaortic or pulmonary valve (PV) region. Both sites may present with a small R wave in lead V1. However, the utility of lead I in distinguishing these arrhythmia locations is unknown. Thirty-six consecutive ...
Xu Luhong L Institute of Cardiovascular Disease Research, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu 221002, - - 2014
The association between the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the severity of coronary artery disease (CAD) diagnosed by coronary angiography and other approaches has been investigated. The clinical application of NT-proBNP is restricted by the drawbacks of these techniques now available in screening out patients who need ...
Fernando Pasan P Nordion, 447 March Road, Ottawa, ON, K2K 1X8, Canada, - - 2014
Myocardial perfusion scintigraphy is a valuable clinical tool for assessing coronary blood flow deficits in patients. We recently synthesized a new iodinated compound ((123)I-CMICE-013) based on rotenone and showed that it has excellent performance as a radiotracer for myocardial perfusion imaging. Here, we describe the cellular toxicity and subacute toxicity ...
Dweck Marc Richard MR British Heart Foundation/University Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, - - 2014
The assessment of myocardial ischemia represents a cornerstone in our approach to coronary artery disease. Indeed many of the clinical decisions we make revolve around the results of stress testing, the assessment of coronary luminal stenoses and, more recently, fractional flow reserve measurements. Whilst the assessment of ischemia is often ...
Iskandrian Ami E AE Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: - - 2014
Myocardial perfusion imaging (MPI) with gated single-photon emission tomography provides important information on the extent and severity of myocardial perfusion abnormalities, including myocardial ischemia. The availability of software for automated quantitative assessment of myocardial perfusion in an objective and more reproducible manner than visual assessment has allowed MPI to be ...
Mordini Federico E FE Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland; Department of Cardiology, Veterans Affairs Medical Center, Washington, - - 2014
This study's primary objective was to determine the sensitivity, specificity, and accuracy of fully quantitative stress perfusion cardiac magnetic resonance (CMR) versus a reference standard of quantitative coronary angiography. We hypothesized that fully quantitative analysis of stress perfusion CMR would have high diagnostic accuracy for identifying significant coronary artery stenosis ...
Shuster Jerrica E JE PGY2 Pharmacy Resident, Cardiology Specialty, Clinical - - 2014
Clinical surveillance systems (CSS) are utilized by many health care institutions to help identify at-risk patients, prioritize care, improve the clinical services provided, and increase compliance with the Center for Medicare and Medicaid Services (CMS) core measures. This study will assess the accuracy and practicality of a CMS acute myocardial ...
De Smedt Delphine D Department of Public Health, Ghent University, Belgium. Electronic address: - - 2014
The aim of this study was to compare EuroQol five-dimensional (EQ-5D) utility scores and six-dimensional health state classification (SF-6D) utility scores (derived from the 12-Item Short-Form Health Survey [SF-12]) by using a large European sample of patients with stable coronary heart disease. Special attention was given to country-specific results. Data ...
Bière Loïc L L'UNAM Université, Angers, France ; Université Angers, UPRES EA3860, Laboratoire Cardioprotection, Remodelage et Thrombose, CHU Angers, Service de Cardiologie, Angers, - - 2014
We assessed the value of speckle tracking imaging performed early after a first ST-segment elevation myocardial infarction (STEMI) in order to predict infarct size and functional recovery at 3-month follow-up. 44 patients with STEMI who underwent revascularization within 12 h of symptom onset were prospectively enrolled. Echocardiography was performed 3.9±1.2 ...
Rakowski Tomasz T Second Department of Cardiology, Jagiellonian University Medical College, Krakow, - - 2014
There are still only limited data concerning the use of creatine kinase-MB (CKMB) values for predicting infarct size in long-term follow up in patients with ST-segment elevation myocardial infarction (STEMI) who have undergone primary percutaneous coronary intervention (PCI). The aim of this study was to analyze the correlation between CKMB ...
Schoenenberger A A Division of Geriatrics, Department of General Internal Medicine, Inselspital, Bern, SWITZERLAND; - - 2014
Prediction of arrhythmic events (AEs) has gained importance with the availability of implantable cardioverter-defibrillators (ICDs), but is still imprecise. This study evaluated the innovative Wedensky modulation index (WMI) as predictor of AEs. In this prospective cohort, 179 patients with coronary artery disease (CAD) referred for AE risk assessment underwent baseline ...
Bekler Adem A Department of Cardiology, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, - - 2014
Background Red cell distribution width (RDW) and fragmented QRS (fQRS) complexes have also been reported to be pre-dictors of cardiac events and all-cause mortality in coronary artery disease (CAD). We aimed to investigate the association of serum red cell distribution width (RDW) levels and fQRS in patients with non-ST elevated ...
Naar Jan - - 2014
Study objective: To compare parameters of diastolic function as assessed by radionuclide ventriculography (RNVG) and Doppler echocardiography (ECHO) in the patients with chronic heart failure and reduced ejection fraction (HF REF). Patients and methods: RNVG and ECHO were performed on the same day in 40 patients with systolic chronic HF, ...
Shen B X BX Department of Radiology, Affiliated Nanshan Hospital of Guangdong Medical College, Shenzhen, Guangdong, China - - 2014
We aimed to assess parameters reflecting left ventricular function by dual-source computed tomography (DSCT) with echocardiography (ECG) as control. Fifty-eight patients with coronary heart disease (CHD) were recruited from January to June 2011; 29 CHD patients had type II diabetes. All patients were assessed by cardiac DSCT and ECG examination. ...
Stähli Barbara Elisabeth BE Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, - - 2014
In patients with suspected acute coronary syndrome (ACS), rapid triage is essential. The aim of this study was to establish a tool for risk prediction of 30-day cardiac events (CE) on admission. 30-day cardiac events (CE) were defined as early coronary revascularization, subsequent myocardial infarction, or cardiovascular death within 30 ...
Qu Xinkai X Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, - - 2014
Accurate assessment of coronary chronic total occlusion (CTO) lesion is essential to design an appropriate procedural strategy before revascularization. The present study aims to evaluate the significance of a single multislice computed tomography (MSCT) examination in patients with CTO lesion. We retrospectively analyzed the clinical data of 23 CTO lesions ...
Jiang Zhibin Z Department of Cardiothoracic Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. - - 2014
Postoperative myocardial infarction (PMI) is one of the most serious complications of cardiac surgeries. No preoperative biomarker is currently available for predicting PMI after cardiac surgeries. In the present study, we used a phage display peptide library to screen potential preoperative peptide biomarkers for predicting PMI after coronary artery bypass ...
Kaplan Sahin S Faculty of Medicine, Karadeniz Technical University Trabzon, - - 2014
Epicardial adipose tissue (EAT) is a tissue around the heart with visceral adipose properties. It can affect the structure and functions of the myocardium and coronary arteries through inflammatory markers and regulators. The myocardial performance (Tei) index is a parameter capable of globally assessing systolic and diastolic heart functions. This ...
Tsai Jang-Zern JZ Department of Electrical Engineering, National Central University, Jhongli City, Taoyuan County, - - 2014
White matter hyperintensities (WMHs) of presumed vascular origin are common in ageing population, especially in patients with acute cerebral infarction and the volume has been reported to be associated with mental impairment and the risk of hemorrhage from antithrombotic agents. WMHs delineation can be computerized to minimize human bias. However, ...
Stevanovic Ana A Department of Anaesthesiology, University Hospital of the RWTH Aachen, Aachen, - - 2014
Cardiac surgery is accompanied by an increase of oxidative stress, a significantly reduced antioxidant (AOX) capacity, postoperative inflammation, all of which may promote the development of organ dysfunction and an increase in mortality. Selenium is an essential co-factor of various antioxidant enzymes. We hypothesized a less pronounced decrease of circulating ...
Abdallah Khaled Omar - - 2014
Bone marrow harbors a population of tissue-committed stem cells that are CD34+/CXCR4+. These potential cardiac progenitors which express cardiac and endothelial markers may contribute to cardiac regeneration. The ability of injured myocardium to recruit extracardiac stem cells after injury would be beneficial to aid in myocardial repair and regeneration. The ...
Keszler Agnes A Department of Anesthesiology, Medical College of Wisconsin Milwaukee, WI, - - 2014
Far red/near-infrared light (NIR) promotes a wide range of biological effects including tissue protection but whether and how NIR is capable of acutely protecting myocardium against ischemia and reperfusion injury in vivo is not fully elucidated. Our previous work indicates that NIR exposure immediately before and during early reperfusion protects ...
Bellera Neus N Laboratory of Experimental and Molecular Cardiocirculatory Pathology, Institut de Recerca, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain (N.B., I.B., A.R.S., D.G.D.) Department of Cardiology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain (N.B., T.G.A., J.R., B.G.B., - - 2014
Small and large preclinical animal models have shown that antagomir-92a-based therapy reduces early postischemic loss of function, but its effect on postinfarction remodeling is not known. In addition, the reported remote miR-92a inhibition in noncardiac organs prevents the translation of nonvectorized miR-targeted therapy to the clinical setting. We investigated whether ...
Nasiripour Somayyeh S Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences and Health Services, Tehran, - - 2014
Heparin and enoxaparin possess anti-inflammatory properties. We compared the effects of these drugs on inflammatory biomarkers in patients with ST-segment Elevated Myocardial Infarction (STEMI). Thirty four patients with STEMI randomly separated in two groups and received standard doses of heparin and enoxaparin. The serum concentration of Serum Amyloid A (SAA), ...
Oka Makiko M Department of Nutrition and Metabolism, the University of Tokushima Graduate - - 2014
Human chymase converts big endothelin (ET)-1 to 31-amino acid length ET-1 {ET-1(1-31)} that also possesses a potent vasoconstrictive action. In addition, ET-1(1-31) is an intermediate peptide, which is then readily transformed to mature ET-1 by the neutral endopeptidase 24-11. To investigate the relevance of pathophysiology of ET-1(1-31) in vivo, we ...
Saboural Pierre P Inserm, U1148, LVTS, Paris Diderot University, Bichat-Claude Bernard Hospital, F-75877, Paris, France. - - 2014
Fucoidans constitute a large family of sulfated polysaccharides with several biochemical properties. A commercial fucoidan from brown algae, containing low molecular weight polysaccharidic species constituted of l-fucose, uronic acids and sulfate groups, was simply treated here with calcium acetate solution. This treatment led to a purified fraction with a yield ...
Frobert Aurélien A Cardiology, Department of Medicine, University of - - 2014
Cardiac cell therapy has gained increasing interest and implantation of biomaterials associated with cells has become a major issue to optimize myocardial cell delivery. Rodent model of myocardial infarction (MI) consisting of Left Anterior Descending Artery (LAD) ligation has commonly been performed via a thoracotomy; a second open-heart surgery via ...
McCormick Margaret E ME Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of - - 2014
A naturally-occurring fragment of tyrosyl-tRNA synthetase (TyrRS) has been shown in higher eukaryotes to 'moonlight' as a pro-angiogenic cytokine in addition to its primary role in protein translation. Pro-angiogenic cytokines have previously been proposed to be promising therapeutic mechanisms for the treatment of myocardial infarction. Here, we show that systemic ...
Chang Dehua D Department of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan; Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, United States of - - 2014
Implantation of cell-sheets into damaged regions of the heart after myocardial infarction (MI) has been shown to improve heart function. However, the tissue morphology following application of induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CM) has not been studied in detail at the level afforded by electron microscopy. We hypothesized that ...
Van De Heyning Caroline M - - 2013
Two-dimensional transthoracic echocardiography (2DTTE) remains the first-line diagnostic imaging tool to assess primary mitral regurgitation although cardiovascular magnetic resonance (CMR) has proven to establish left ventricular function more accurately and might evaluate mitral regurgitation severity more reliably. We sought to compare routine evaluation of left ventricular function and mitral regurgitation ...
Taylor Richard Andrew RA Department of Emergency Medicine, Yale University School of Medicine, New Haven, CT 06519 USA. Electronic address: - - 2013
Pulmonary embolism (PE) is a common emergency department (ED) diagnosis with a wide range in mortality rates. Methods to identify and risk-stratify PE, including measuring right ventricular strain (RVS) by echocardiography (echo), are essential in providing effective and efficient care. A limited echo examination aims to expedite and increase availability ...
Chow Benjamin Jw - - 2013
The prevalence of heart failure (HF) is rising in industrialized and developing countries. Though invasive coronary angiography (ICA) remains the gold standard for anatomical assessment of coronary artery disease in HF patients, alternatives are being sought. Computed tomographic coronary angiography (CTA) has emerged as an accurate non-invasive diagnostic tool for ...
Schmidt Renate R Adult Congenital and Valvular Heart Disease Center, Department of Cardiology and Angiology, University Hospital of Münster, Münster, - - 2013
Patients are commonly affected by ventricular dysfunction and heart failure after Fontan palliation. Reliable quantification of ventricular function is of interest but hampered by complex ventricular anatomy and physiology. We aimed to assess myocardial function using a novel cardiac magnetic resonance imaging (CMR)-based feature-tracking (FT) technique and to study its ...
Sakamoto Fumi F Department of Diagnostic Radiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Kumamoto, 860-0821, Japan, - - 2013
We assessed the value of combining (123)I-IMP brain perfusion SPECT and (123)I-MIBG myocardial scintigraphy for the discrimination of dementia with Lewy bodies (DLB) from other types of dementia. We subjected 252 consecutive patients with clinically suspected DLB to both (123)I-IMP brain perfusion SPECT and (123)I-MIBG myocardial scintigraphy. Patients with Parkinson's ...
Zafar Haroon H Tissue Optics & Microcirculation Imaging Facility, National University of Ireland, Galway, Ireland; National Biophotonics & Imaging Platform, Dublin, Ireland. Electronic address: - - 2013
The main objective of this study is to determine the correlation between fractional flow reserve (FFR)- and frequency domain optical coherence tomography (FD-OCT)-measured lumen parameters, and to determine the diagnostic competence of FD-OCT concerning the identification of severe coronary stenosis. A total of 41 coronary stenoses in 30 patients were ...
Wildgruber Moritz M 1Department of Diagnostic and Interventional Radiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; International Graduate School of Science and Engineering, Technische Universität München, Garching, - - 2013
-To prospectively evaluate an elastin-specific magnetic resonance contrast agent (ESMA) for in-vivo targeting of elastic fibers in myocardial infarction and post-infarction scar remodeling. -Myocardial infarction (MI) was induced in C57BL/6J mice (n=40) by permanent ligation of the left anterior descending coronary artery (LAD). Magnetic Resonance Imaging (MRI) was performed at ...
Mueller Christian C Department of Cardiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, - - 2013
Biomarkers complement clinical assessment and the 12-lead ECG in the diagnosis, risk stratification, triage, and management of patients with suspected acute coronary syndrome (ACS). While there is broad consensus that cardiac troponin (cTn) I or T is the preferred biomarker in clinical practice, important uncertainties remain regarding the value of ...
Gimelli Alessia A Fondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, 56124 Pisa, - - 2013
To investigate the relationships between regional adrenergic innervation heterogeneity, myocardial perfusion, and contractile function obtained by means of a low-dose imaging protocol with a cadmium-zinc-telluride (CZT) dedicated camera. Twenty-eight patients with or without ischaemic heart disease underwent (123)I-metaiodobenzylguanidine (MIBG) planar scintigraphic and CZT early and delayed evaluations followed by (99m)Tc-tetrofosmin ...
Frederiksen Christian Alcaraz - - 2013
The aim of the study was to compare the diagnostic accuracy of point-of-care cardiac ultrasonography performed by a novice examiner against results from a specialist in cardiology with expert skills in echocardiography, with regard to the assessment of six clinically relevant cardiac conditions in a population of ward patients from ...
Miller Christopher A CA North West Heart Centre and The Transplant Centre, University Hospital of South Manchester, Wythenshawe Hospital, Manchester, UK; Centre for Imaging Sciences & Biomedical Imaging Institute, University of Manchester, UK; Institute of Cardiovascular Sciences, University of Manchester, UK. Electronic address: - - 2013
To evaluate the diagnostic performance of multiparametric cardiovascular magnetic resonance (CMR) for detecting cardiac allograft vasculopathy (CAV) using contemporary invasive epicardial artery and microvascular assessment techniques as reference standards, and to compare the performance of CMR with that of angiography. CAV continues to limit the long-term survival of heart transplant ...
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