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Greenwood John J Multidisciplinary Cardiovascular Research Centre Leeds - - 2014
CE-MARC was the largest prospective evaluation of the diagnostic accuracy of CMR in coronary artery disease. CE-MARC adopted a multi-parametric protocol assessing ventricular function, myocardial perfusion, viability (with late gadolinium enhancement (LGE)) and coronary artery anatomy. Previous small studies have shown the diagnostic accuracy of different components of the CMR ...
Morley-Smith Andrew A Imperial College London and Royal - - 2014
There are few non-invasive techniques to predict and monitor patients' responses to left ventricular assist device (LVAD) therapy. MicroRNAs (miRs) are small noncoding RNAs with intricate roles in cardiovascular disease. They remain stable in the circulation, are readily quantified, and may be useful as new biomarkers. This study sought to ...
Anthony David D Memorial Hospital of Rhode Island, 111 Brewster St, Pawtucket, RI 02903, - - 2014
Patients with acute chest pain should be assessed first for the likelihood of acute coronary syndrome using the Thrombolysis in Myocardial Infarction score or the Agency for Health Care Policy and Research criteria. If assessment indicates high risk, the patient should be admitted to the hospital. Low- and intermediate-risk patients ...
Seo Yoshihiro Y Cardiovascular Division, Faculty of Clinical Medicine, University of Tsukuba, Tsukuba, - - 2014
Cardiac function analysis is the main focus of echocardiography. Left ventricular ejection fraction (LVEF) has been the clinical standard, however, LVEF is not enough to investigate myocardial function. For the last decade, speckle tracking echocardiography (STE) has been the novel clinical tool for regional and global myocardial function analysis. However, ...
Watkins Stuart S Golden Jubilee - - 2014
Myocardial fractional flow reserve (FFR) has uncertain validity in patients with recent myocardial infarction and the use of FFR in this setting is controversial. We performed a prospective study to assess the diagnostic accuracy of FFR in patients with a recent non-ST segment myocardial infarction (NSTEMI). NSTEMI patients who had ...
Puntmann Valentina V King's College - - 2014
T1 and T2 mapping detect myocardial fibrosis and oedema respectively. T1 values show segmental variation in mid ventricular SAX slice, making the identification of regional pathology difficult.We tested the reproducibility of T1 and T2 mapping in health and disease and regional variations of T2 values. Patients with non-ischaemic cardiomyopathy (NICM, ...
Liu Yong Y Department of Neurology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China ; Department of Neurology, Taihe Hospital Affiliated to Hubei University of Medicine, Shiyan, Hubei Province, - - 2014
Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic preconditioning in rats by simulating a transient ischemic attack twice (each a 20-minute occlusion of the middle cerebral artery) before inducing focal cerebral infarction (2 hour ...
Khan Jamal J University of - - 2014
There is no consensus on the optimal method of quantifying infarct size (IS) on late gadolinium imaging (LGE) or area at risk (oedema, [AAR]) on T2-weighted STIR (T2wSTIR) in patients with ST-segment elevation myocardial infarction (STEMI).Semi-automated standard deviation (SD) based techniques, manual contouring of enhancement, and full-width half-maximum (FWHM) methods ...
Gonzalez-Gonzalez Ana M AM Royal Brompton - - 2014
The prognostic value of myocardial perfusion (MP), assessed during stress echocardiography (SE) by myocardial contrast echocardiography (MCE), has been shown in research studies but is untested in a 'real-world' clinical SE service. Patients clinically referred for SE undergoing pharmacological stress, and those doing exercise stress in whom we suspected target ...
Dercle Laurent L Department of Nuclear Medicine, Toulouse University Hospital, 1, Avenue Jean Poulhès TSA 50032, 31059, Toulouse Cedex 9, France, - - 2014
The assessment of right ventricular function is crucial for management of heart disease. TOMPOOL is a software that processes data acquired with Tomographic Equilibrium Radionuclide Ventriculography. In this report, TOMPOOL's diagnostic accuracy and inter-observer reproducibility were assessed in a cohort of patients with various etiologies of ventricular dysfunction. End-diastolic volume ...
Sato Akira A Akira Sato, Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8577, - - 2014
Coronary computed tomography angiography (CTA) has become the useful noninvasive imaging modality alternative to the invasive coronary angiography for detecting coronary artery stenoses in patients with suspected coronary artery disease (CAD). With the development of technical aspects of coronary CTA, clinical practice and research are increasingly shifting toward defining the ...
Meneveau Nicolas N Department of Cardiology, EA3920, University Hospital Jean Minjoz, 25000 Besançon, France. Electronic address: - - 2014
To date, no randomized study has investigated the value of optical coherence tomography (OCT) in optimizing the results of coronary angioplasty for non-ST-segment elevation acute coronary syndromes. DOCTORS is a randomized, prospective, multicenter, open-label clinical trial to evaluate the utility of OCT to optimize results of angioplasty of a lesion ...
Harada Haruhito H Department of Cardiology, Kurume University Medical Center, 155-1, Kokubu-machi, Kurume, 839-0863, Japan, - - 2014
We assessed the effects of long-term laronidase replacement therapy (LRT) on the left ventricular (LV) function of a 52-year-old adult woman with mucopolysaccharidosis I (MPS I). The urinary uronic acid concentration significantly decreased by 78.7% (from 75 to 16 mg/g creatinine) after LRT; thereafter, estimated LV weight as assessed by two-dimensional ...
Meinel Felix G FG 1 Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, MSC 226, Charleston, SC - - 2014
OBJECTIVE. The purpose of this study was to determine the feasibility of global quantitative measurements of left ventricular myocardial perfusion derived from stress dynamic CT myocardial perfusion imaging. MATERIALS AND METHODS. The coronary CT angiographic and CT myocardial perfusion imaging datasets of 146 patients were visually evaluated for the presence ...
Oner Ender E Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital. - - 2014
Previous studies comparing levosimendan vs dobutamine have revealed that levosimendan is better in relieving symptoms. Echocardiographic studies have been done using second measurements immediately following a dobutamine infusion or while it was still being administered. The aim of our study was assessment of sustained effects of 24 hours levosimendan and ...
Meric Murat M Department of Cardiology, Ondokuz Mayis University Faculty of Medicine, 55139, Kurupelit, Samsun, Turkey, - - 2014
The myocardial performance index (MPI) reflects both the systolic and diastolic function of the heart, and is easily applied in practice. In this study, we aimed to determine the relationship between MPI and invasive haemodynamic parameters in heart failure patients. A total of 126 patients with heart failure were selected, ...
Lankveld Theo A R TA Department of Cardiology, Maastricht University Medical Centre, Maastricht, The - - 2014
The use of the ECG for atrial fibrillation (AF) in clinical daily practice is still limited to its diagnosis. Recent research shows however that ECG-derived parameters can also be used to assess the spatiotemporal properties of AF. Specifically, the complexity of the f-waves in the ECG reflects the complexity of ...
Cooper Howard A HA MedStar Heart Institute, MedStar Washington Hospital Center, USA - - 2014
Current diagnostic criteria for cardiogenic shock (CS) require the use of a pulmonary artery catheter (PAC), which is time-consuming and may cause complications. A set of simple yet accurate noninvasive diagnostic criteria would be of significant utility. Candidate components for the Noninvasive Parameters for Assessment of Cardiogenic Shock (N-PACS) criteria ...
Weng Andreas Max AM Department of Radiology, University of Würzburg, Würzburg, - - 2014
Objectives To calculate and evaluate absolute quantitative myocardial perfusion maps from rest first-pass perfusion MRI. Methods 10 patients after revascularization of myocardial infarction underwent cardiac rest first-pass perfusion MRI. Additionally, perfusion examinations were performed in 12 healthy volunteers. Quantitative myocardial perfusion maps were calculated by using a deconvolution technique and ...
Wu Zhiming Z Department of Cardiology, Nanjing First Hospital Affiliated to Nanjing Medical University, No. 68, Changle Street, Nanjing City, People's Republic of China, - - 2014
This study sought to investigate the relationship between the index of microcirculatory resistance (IMR) and periprocedural myocardial necrosis in patients with unstable angina pectoris (UAP). Fifty-seven UAP patients undergoing elective percutaneous coronary intervention (PCI) of a single lesion were recruited. A pressure-temperature sensor wire was used to measure IMR immediately ...
Ahmed Bina B Division of Cardiology, School of Medicine, University of New Mexico, Albuquerque, New Mexico, - - 2014
The coronary microvasculature plays a key role in determining and modulating coronary blood flow across the spectrum of myocardial demand. Our understanding of this complex system has been limited partly due to our inability to visualize the anatomy of an extensive microvascular bed and its complicated functional pathways. Nonetheless, research ...
Taylor Robin J RJ Department of Cardiology, The Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, United Kingdom; Centre for Cardiovascular Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United - - 2014
Myocardial tagging using cardiovascular magnetic resonance (CMR) is the gold-standard for the assessment of myocardial mechanics. Feature-tracking cardiovascular magnetic resonance (FT-CMR) has been validated against myocardial tagging. We explore the potential of FT-CMR in the assessment of mechanical dyssynchrony, with reference to patients with cardiomyopathy and healthy controls. Healthy controls ...
Bailliez Alban A Nuclear Medicine Department, IRIS, Polyclinique du Bois, 144 avenue de Dunkerque, 59000, Lille, France, - - 2014
We evaluated gated-SPECT using a Cadmium-Zinc-Telluride (CZT) camera for assessing global and regional left ventricular (LV) function. A phantom study evaluated the accuracy of wall thickening assessment using systolic count increase on both Anger and CZT (Discovery 530NMc) cameras. The refillable phantom simulated variable myocardial wall thicknesses. The apparent count ...
Pislaru Cristina C Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. Electronic address: - - 2014
Our aims were (i) to compare in vivo measurements of myocardial elasticity by shear wave dispersion ultrasound vibrometry (SDUV) with those by the conventional pressure-segment length method, and (ii) to quantify changes in myocardial viscoelasticity during systole and diastole after reperfused acute myocardial infarction. The shear elastic modulus (μ1) and viscous ...
Sinnecker Daniel D Medizinische Klinik der Technischen Universität München, Munich, - - 2014
We recently reported that nocturnal respiratory rate (NRR) predicts non-sudden cardiac death in survivors of myocardial infarction (MI). Here, we present the details of the technique deriving NRR from ECG recordings. Continuous ECG and respiratory chest excursions were simultaneously recorded in 941 MI survivors who were followed-up for 5-years. Mean ...
Kaul Sanjiv S Knight Cardiovascular Institute UHN-62, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA. Electronic address: - - 2014
If 'no reflow' is observed within 45min of reperfusion using balloon angioplasty or stent, it is probably related to microthromboemboli, which may also contribute to the extension of the 'no reflow' zone by converting 'low reflow' areas into necrotic ones even when reperfusion is achieved more than 45min after the ...
Kondo Masatoshi M Department of Medical Technology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-Ku, Fukuoka City, Fukuoka 812-8582, Japan. Electronic address: - - 2014
To investigate the effect of dual-bolus contrast media injection (dual-CM) on the accuracy of automated right ventricular (RV) segmentation on coronary computed tomography angiography (CCTA). A total of 104 patients with suspected and known coronary artery disease underwent 256-slice CCTA with retrospective electrocardiographic (ECG) gating. The patients were divided into ...
Tsai Jui-Peng JP aDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming University bDepartment of Internal Medicine, Division of Cardiology cDepartment of Radiology, Mackay Memorial Hospital dMackay Medicine, Nursing and Management College, Taipei, - - 2014
The aim of this meta-analysis was to examine the diagnostic accuracy of single-photon emission computed tomography (SPECT) for the assessment of myocardial viability in patients with coronary artery disease as compared with PET. The literature was searched using the following keywords: single-photon emission computed tomography, positron emission tomography, perfusion, viability, ...
Danad Ibrahim I Department of Cardiology, VU University Medical Center, Amsterdam, De Boelelaan 1117, 1081 HV, The - - 2014
Myocardial ischaemia occurs principally in the subendocardial layer, whereas conventional myocardial perfusion imaging provides no information on the transmural myocardial blood flow (MBF) distribution. Subendocardial perfusion measurements and quantification of the transmural perfusion gradient (TPG) could be more sensitive and specific for the detection of coronary artery disease (CAD). The ...
Gerbaud Edouard E Soins Intensifs Cardiologiques - Plateau de Cardiologie Interventionnelle, CHU de Bordeaux, Hôpital du Haut Lévêque, 5 avenue de Magellan, F33604 Pessac, - - 2014
Objectives: To develop a new method for the CMR quantification of peri-infarct ischemia using fused perfusion and delayed-enhanced images and to evaluate this method using quantitative SPECT imaging as a reference. Methods: Forty patients presenting with a peri-infarct ischemia on a routine stress 99mTc-SPECT imaging were recruited. Within 8 days ...
Herod Jerrell W JW Division of Cardiology, University of Colorado, Aurora - - 2014
Right ventricular (RV) failure is a major cause of morbidity and mortality after left ventricular assist device (LVAD). Whether RV function deteriorates with prolonged LVAD support is unknown. Speckle-tracking echocardiography provides a sensitive, noninvasive, reproducible, and quantitative assessment of RV systolic and diastolic function. Echocardiograms were retrospectively reviewed from before ...
Olson Charles W CW ECG-TECH Corp, Huntington, - - 2014
The purpose of this study is to present a new and improved method for translating the electrocardiographic changes of acute myocardial ischemia into a display which reflects the location and extent of the ischemic area and the associated culprit coronary artery. This method could be automated to present a graphic ...
Gomis Pedro P Department ESAII, EUETIB, Universitat Politècnica de Catalunya (UPC), Barcelona, Spain; CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Spain. Electronic address: - - 2014
Low-level electrocardiographic changes from depolarization wavefront may accompany acute myocardial ischemia. The purpose of this study was to assess the changes of microvolt amplitude intra-QRS potentials induced by elective percutaneous coronary interventions (PCI). Fifty-seven patients with balloon inflation periods ranging from 3.1 to 7.3minutes (4.9±0.7min) were studied. Nine leads continuous ...
Bao Mike H MH Canadian VIGOUR Centre, University of Alberta, Edmonton, AB, - - 2014
To evaluate quantitative relationships between baseline Q-wave width and 90-day outcomes in ST-segment elevation myocardial infarction (STEMI). Baseline Q-waves are useful in predicting clinical outcomes after MI. 3589 STEMI patients were assessed from a multi-centre study. 1156 patients of the overall cohort had pathologic Q-waves. The 90-day mortality and the ...
Lazzeri Chiara C Chiara Lazzeri, Serafina Valente, Marco Chiostri, Maria Grazia D'Alfonso, Gian Franco Gensini, Intensive Cardiac Care Unit, Heart and Vessel Department, Azienda Ospedaliero, Universitaria Careggi, 50134 Florence, - - 2014
In population-based studies, including diabetic and nondiabetic cohorts, glycated hemoglobin A1c (HbA1c) has been reported as an independent predictor of all-cause and cardiovascular disease mortality. Data on the prognostic role of HbA1c in patients with acute myocardial infarction (MI) are not univocal since they stem from studies which mainly differ ...
Mihl Casper C Department of Radiology, Maastricht University Medical Center, P. Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands; CARIM, School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, The - - 2014
Epicardial adipose tissue (EAT) is emerging as a risk factor for coronary artery disease (CAD). The aim of this study was to determine the applicability and efficiency of automated EAT quantification. EAT volume was assessed both manually and automatically in 157 patients undergoing coronary CT angiography. Manual assessment consisted of ...
Balzer Jan C JC Heinrich-Heine-University Dusseldorf, Dusseldorf, - - 2014
Aims: Introduction of a novel contrast injection protocol during rotational C-arm CT (RCT) in cardiac catheterisation of patients with aortic stenosis for aortic root assessment. Methods and results: Fifty-two patients underwent RCT imaging with contrast injection performed either into the aorta (Ao-RCT, n=25) or into the left ventricle (LV-RCT, n=27). ...
Maruyama Mitsunori M From the Cardiovascular Center, Chiba-Hokusoh Hospital (M.M., T.Y., J.A., Y.S.) and Department of Cardiovascular Medicine (K.Y., W.S.), Nippon Medical School, Tokyo, Japan; and Tama-Nagayama Hospital & Nippon Medical School, Tokyo, Japan (H.A.). - - 2014
Measuring postpacing intervals (PPIs) is the standard maneuver for localizing reentrant tachycardia circuits. However, changes or termination of the tachycardia during entrainment pacing, or difficulties in defining the correct local activity, limit the use of PPIs. We hypothesized that the number of pacing stimuli needed to entrain (NNE) was useful ...
Maurer M H - - 2014
Purpose: Assessment of experience gained by local referring physicians with the procedure of coronary computed tomographic angiography (CCTA) in the everyday clinical routine. Materials and Methods: A 25-item questionnaire was sent to 179 physicians, who together had referred a total of 1986 patients for CCTA. They were asked about their ...
Burzotta Francesco - - 2014
The management of patients with angiographically intermediate coronary lesions is a major clinical issue. Fractional flow reserve provides validated functional insights while optical coherence tomography provides high resolution anatomic imaging. Both techniques may be applied to guide management in case of angiographically intermediate coronary lesions. Moreover, these techniques may be ...
Tanaka Tetsuya T Division of Cardiology, Japan Community Health care Organization, Kobe Central Hospital, 2-1-1 Souyamacho, Kita-ku, Kobe, Hyogo, 651-1145, Japan, - - 2014
We investigated changes of the complexity of coronary artery disease (CAD) after drug-eluting stent (DES) implantation using SYNTAX score and the predictor of worsened SYNTAX score at follow-up. 116 consecutive patients who underwent de novo PCI with first-generation DES were enrolled. SYNTAX scores were obtained from coronary angiography before PCI, ...
Dianati Maleki Neda N University of Alberta, Edmonton, AB, Canada; Mt. Sinai Health System/St. Luke's-Roosevelt Hospital Center, New York, NY, - - 2014
After about a century since its clinical introduction, the 12-lead electrocardiogram (ECG) remains a cornerstone in diagnosis and management of acute ST-elevation myocardial infarction (STEMI). It provides clinicians and researchers with invaluable information regarding the presence, location, and extent of myocardial infarction. Moreover the ECG contains a wealth of prognostic ...
Guérard Nicolas N Novartis Institutes for Biomedical Research, Novartis Pharma AG, Werk Klybeck, Klybeckstrasse 141, WKL.136.176, 4057, Basel, Switzerland, - - 2014
Reduced repolarization reserve and increased transmural dispersion of repolarization (TDR) are known risk factors for Torsade de Pointes development, but less is known about the role of apex-to-base (apicobasal) repolarization in arrhythmogenesis. Three needles were inserted in rabbit left ventricle to record unipolar electrograms from endocardium to epicardium and base ...
Kobayashi Yuhei Y Division of Cardiovascular Medicine, Stanford University Medical - - 2014
Assessment of the coronary microvasculature in the clinical setting is a key issue, given that microvascular dysfunction itself has a predictive value for cardiovascular events. The index of microcirculatory resistance (IMR) is an invasive method of interrogating the microvasculature and provides further insight into the physiology of cardiovascular diseases. It ...
Belardinelli Romualdo R Cardiologia Riabilitativa e Preventiva, Azienda Ospedali Riuniti Lancisi-Umberto I-Salesi, Ancona, Italy. Electronic address: - - 2014
Cardiopulmonary exercise stress testing (CPET) is used to grade the severity of heart failure and to assess its prognosis. However it is unknown whether CPET may improve diagnostic accuracy of standard ECG stress testing to identify or exclude obstructive coronary artery disease (O-CAD) in patients with chest pain. We prospectively ...
Engblom Henrik H Department of Clinical Physiology and Nuclear Medicine, Lund University and Skåne University Hospital, Lund, - - 2014
In order to determine the cardioprotective efficacy of acute reperfusion therapy, assessed as myocardial salvage, in patients with acute coronary occlusion, the final myocardial infarct (MI) size needs to be related to the amount of ischemic myocardium during coronary occlusion, referred to as the myocardium at risk (MaR). There are ...
Wong Dennis T L DT Discipline of Medicine, University of Adelaide, Adelaide, Australia, - - 2014
We evaluate whether circumferential strain derived from grid-tagged CMR is a better method for assessing improvement in segmental contractile function after STEMI compared to late gadolinium enhancement (LGE). STEMI patients post primary PCI underwent baseline CMR (day 3) and follow-up (day 90). Cine, grid-tagged and LGE images were acquired. Baseline ...
Schwalm Jon-David R JD McMaster University/Hamilton Health Sciences/Population Health Research Institute, Hamilton, Ontario, Canada. Electronic address: - - 2014
The Variation in Revascularization Practice in Ontario (VRPO) project helped describe variations in revascularization across Ontario. Coronary anatomy was the most important predictor of revascularization strategy. We conducted a novel angiographic substudy of the VRPO cohort to: (1) validate "real-world" coronary angiographic reporting in the province of Ontario; and (2) ...
Chen Xiuyu X Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, 167 Beilishi Road, Xi Cheng District, Beijing, 100037, - - 2014
To investigate the relationship between electrocardiographic (ECG) abnormalities and left ventricular (LV) segmental hypertrophy and myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy (HCM). 118 asymptomatic or mildly symptomatic patients with HCM were examined with late gadolinium enhancement (LGE) CMR, 12-lead ...
Zeller Tanja T Department of General and Interventional Cardiology, University Heart Center Hamburg, Martinistr. 52, 20246 Hamburg, - - 2014
While cardiac troponin measurements have significantly improved the early diagnosis of myocardial infarction, the timely biomarker-based diagnosis of unstable angina pectoris (UAP) remains a major unmet clinical challenge. The aim of this study was to assess levels of circulating microRNAs (miRNAs) as possible novel biomarkers in patients with UAP. A ...
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