Search Results
Results 401 - 450 of 1430
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Shechter Michael - - 2007
BACKGROUND: Endothelial dysfunction is recognized as a major factor in the development of atherosclerosis and it has a prognostic value. OBJECTIVES: To detect the long-term association of peripheral vascular endothelial function and clinical outcome in healthy subjects and patients with cardiovascular disease. METHODS: We prospectively assessed brachial artery flow-mediated dilatation ...
Benner Joshua S - - 2007
OBJECTIVE: To test the primary study hypothesis that a physician-delivered coronary heart disease risk evaluation and communication program can lower patients' predicted 10-year risk of myocardial infarction or death due to coronary heart disease by 10% within 6 months compared to usual care. DESIGN: Prospective, parallel group, open-label, controlled, cluster-randomized ...
Hoefle Guenter - - 2007
No prospective data demonstrating an association between the -11377 C > G adiponectin gene promoter variant and cardiovascular risk are available. We therefore prospectively evaluated the cardiovascular risk associated with adiponectin gene single nucleotide polymorphisms (SNPs) including SNP -11377 in a consecutive series of men undergoing coronary angiography. We recorded ...
Hata Jun - - 2007
Brain infarction is one of the common causes of death and also a major cause of severe disability. To identify a gene(s) susceptible to brain infarction, we performed a large-scale association study of Japanese patients with brain infarction, using 52608 gene-based single nucleotide polymorphism (SNP) markers. Comparison of allele frequencies ...
Troughton Judith A - - 2007
BACKGROUND: Classic coronary heart disease risk factors fail to explain the large coronary heart disease incidence gradient between Northern Ireland and France. The Prospective Epidemiological Study of Myocardial Infarction (PRIME), a multicentre prospective study of 10593 men, aims to investigate novel risk factors in these populations. We tested the hypothesis ...
Kardys Isabella - - 2007
Fibrin network structure has been correlated with coronary disease. Fibrinogen gamma and alpha (FGG and FGA) gene haplotypes (chromosome 4q28) may be associated with fibrin network structure, and thereby with rigidity of the fibrin clot and sensitivity of the fibrin clot to the fibrinolytic system. Through these mechanisms they may ...
Neumann Franz-Josef - - 2007
Is coronary revascularisation being underused in patients at highest risk, and overused in those at lower risk?
Koch Werner - - 2007
PURPOSE: Haplotypes based on polymorphisms in the gene encoding 5-lipoxygenase-activating protein have been linked with susceptibility to myocardial infarction in Iceland and the United Kingdom. We sought to replicate these association findings in a large case-control sample from Germany. METHODS: The case group included 3657 patients with myocardial infarction and ...
Khan Usman - - 2007
BACKGROUND: The mechanisms of cerebral small vessel disease (SVD) are unclear. Both atherosclerosis and a non-atherosclerotic diffuse arteriopathy have been reported pathologically. Two pathological and radiological subtypes have been suggested: localised atherosclerotic disease in larger perforating arteries causing larger lacunar infarcts without leukoaraiosis, and diffuse disease in smaller arterioles causing ...
Vojácek J - - 2008
Tissue factor is a cell surface protein that is expressed constitutively by monocytes, macrophages and fibroblasts, but also by some other cells in response to a variety of stimuli. The main function of the tissue factor is to form a complex with factor VII/VIIa that converts factors IX and X ...
Hellstrom H R - - 2007
In this communication, a pathogenetic mechanism for COX-2 inhibitor (coxib)-induced cardiovascular events, especially myocardial infarction, will be discussed. This mechanism is proposed to be useful in structuring medical testimony in rofecoxib trials, and specific principles for separating rofecoxib-induced infarctions from the overall group of rofecoxib-related infarctions will be outlined. The ...
Lorenzová Alena - - 2007
BACKGROUND: It has been shown that high-sensitivity C-reactive protein (hsCRP) concentrations are associated with elevated risk of myocardial infarction, but the mechanisms regulating hsCRP concentration are not completely elucidated yet. In our study, association of interleukin-10 (IL-10) and CD14 polymorphisms and environmental factors with the risk of myocardial infarction was ...
Franco Erica - - 2007
BACKGROUND: The renin-angiotensin-aldosterone system (RAAS) is involved in the cardiovascular homeostasis as shown by previous studies reporting a positive association between specific RAAS genotypes and an increased risk of myocardial infarction. Anyhow the prognostic role in a long-term follow-up has not been yet investigated. Aim of the study was to ...
García-Pinilla José M - - 2007
Various common genotypes of the polymorphism 677 C-->T of the methylenetetrahydrofolate reductase enzyme result in lower activity of the enzyme and in a subsequent increase in homocysteine levels. Many studies have analyzed the connection between this polymorphism and the beginning of coronary artery disease. However, conclusions have been controversial, and ...
Tang Weihong - - 2007
Data accumulated from mouse studies and in vitro studies of human arteries support the notion that soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play important roles in the inflammation process involved in atherosclerosis. However, at the population level, the utility of sICAM-1 and MCP-1 as biomarkers for ...
Piestrzeniewicz Katarzyna - - 2007
Background: Leptin, a hormone-like peptide secreted by adipose tissue, is a strong correlate of obesity. Conflicting data exist concerning leptin as an independent risk factor of coronary artery disease. The aim of the study was to assess the relationship between leptin and obesity and cardiovascular risk factors in men with ...
Bereczky Zsuzsanna - - 2007
INTRODUCTION: The results on the association of factor XIII (FXIII) A subunit (FXIII-A) Val34Leu polymorphism with the risk of myocardial infarction (MI) are rather inconclusive. The original paper and confirmatory reports demonstrated a protective effect of the mutation, but results demonstrating the lack of protection have also been published. Gene-gene ...
Yasunaga Tomohiko - - 2007
A 45-year-old man without major coronary risk factors, including hypertension, diabetes mellitus, smoking, hypercholesterolemia, hyperuricemia, or a family history of early cardiovascular disease, presented with acute coronary syndrome. Angiography showed thrombus formation in segment 7 of the left anterior descending coronary artery, and percutaneous coronary intervention was successful after implantation ...
Gaddi Antonio - - 2007
Familial combined hyperlidemia (FCH) is a common metabolic disorder characterized by: (a) increase in cholesterolemia and/or triglyceridemia in at least two members of the same family, (b) intra-individual and intrafamilial variability of the lipid phenotype, and (c) increased risk of premature coronary heart disease (CHD). FCH is very frequent and ...
Maitland-van der Zee Anke-Hilse - - 2007
The aim of this study was to determine whether the angiotensin-converting enzyme (ACE) insertion-deletion (ID) polymorphism interacts with pravastatin to modify the risk of coronary heart disease (CHD) and other cardiovascular end points in a large clinical trial. GenHAT is an ancillary study of the ALLHAT. The ACE ID genotyped ...
Luo Albert K - - 2007
Coronary artery disease and acute myocardial infarction are complex traits in which there has been recent research to identify the principal genes that engender susceptibility or provide protection. Although there has been exceptional progress in the technology, which now allows genotyping of hundreds of thousands of single-nucleotide polymorphisms in each ...
Pilbrow Anna P - - 2007
Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy. In this study, heart failure patients (n=451) were genotyped for the angiotensinogen M235T and T174M polymorphisms to investigate association with survival (recorded over 4 years of follow-up) and prognostic hormone ...
Suk Danik J - - 2006
The aim of this research was to assess whether common genetic variants within the C-reactive protein gene (CRP) are related to the degree of acute rise in plasma C-reactive protein (CRP) levels following an acute coronary syndrome (ACS). While polymorphisms within CRP are associated with basal CRP levels in healthy ...
Charytan D - - 2006
Chronic kidney disease (CKD) is associated with a high risk of death from coronary artery disease and may modify the response to standard cardiovascular therapies. Treatment of subjects with CKD should ideally be based on evidence from randomized, clinical trials, but how often subjects with CKD have been excluded from ...
Nishigaki Yutaka - - 2007
Superoxide, which mitochondria mainly produce in vascular endothelial cells, plays an important role in the pathogenesis of atherosclerosis and coronary artery disease. Accordingly, mitochondrial functional differences are thought to be one of the most important factors for the risk of myocardial infarction among various individuals. In the present study, we ...
Imano Hironori - - 2007
BACKGROUND: Leukocyte count is recognized as an inflammatory marker and a predictor of cardiovascular events. However, it is uncertain whether the contribution of leukocyte count to the risk of cardiovascular disease is independent of smoking. METHODS: The subjects were 4492 male employees aged 40-59 years who worked for nine companies ...
Kim Sang-Wook - - 2006
BACKGROUND: The impact of cardiovascular risk factors on subclinical but measurable left main coronary artery (LMCA) atherosclerosis is not well known. METHODS: We analyzed 150 consecutive patients with first-time coronary artery disease presentation undergoing intervention of a left anterior descending coronary artery or left circumflex lesion with motorized intravascular ultrasound ...
Boodhwani Munir - - 2006
Despite improvements in its medical and surgical management, ischemic coronary disease remains responsible for significant morbidity, mortality, and economic burden in developed nations. Therapeutic myocardial angiogenesis is an attractive treatment option for patients with end-stage coronary disease who have failed percutaneous and surgical methods of revascularization. Over the past decade, ...
Skala Judith A - - 2006
OBJECTIVE: Both behavioural and physiological factors have been proposed as mechanisms that may explain the negative effect of depression on coronary heart disease (CHD). Our aim is to review some of the most important findings since our prior review. METHOD: We searched MEDLINE, PsycINFO, and other sources for recent studies ...
Yende Sachin - - 2006
PURPOSE OF REVIEW: Interest in the genetic determinants of complications of cardiovascular disease, and the resultant influence on management, has increased. We have therefore reviewed the literature in the last 12-16 months for studies documenting genetic risk of complications. The focus is on risk of complications or differences in management, ...
Pasalić Daria - - 2006
This study was performed to assess the effect of the S447X and Hind III lipoprotein lipase gene polymorphisms on development of coronary artery disease and hypertriglyceridemia. The study included 132 patients and 98 healthy control subjects of Croatian descent. The lipoprotein lipase S447X polymorphism was associated with coronary artery disease ...
García-Palmieri Mario R - - 2006
Eighty percent of coronary deaths occur in people above 65 years of age. Fifty percent of deaths in persons above 85 years of age is due to coronary artery disease. The overall aging of the population and the improvement in survival of patients with coronary artery disease has been creating ...
Gurfinkel Enrique P - - 2006
PURPOSE OF REVIEW: There is an enormous literature on the prevention of myocardial infarction. However, most articles are focused categorically on evidence-based medicine and give no room for conceptual analyses. In this article, we attempt to review the main aspects of this theme from a different point of view. RECENT ...
Myśliwska Jolanta - - 2006
IL6 gene promoter polymorphisms may influence the outcome of cardiovascular diseases. The aim of our study was to find out whether the -174G>C polymorphism, as well as the IL6 secretory profile, may be linked to the number of severely (> or = 75%) occluded coronary arteries in patients with advanced ...
Ryan Ronan - - 2006
BACKGROUND: Genes in the class III region of the MHC, encoding proteins involved in inflammation and vascular regulation, were investigated for association with the occurrence of vasodilation and requirement for vasopressor infusion. METHODS: A cohort of 236 elective cardiac surgical patients was studied. Hemodynamic and metabolic variables and dosage of ...
Goldenberg Ilan - - 2006
The M235T mutation of the human angiotensinogen gene has been shown to be associated with elevated circulating angiotensinogen concentrations and essential hypertension. The frequencies of the 235T allele are significantly different in black and white subjects. We analyzed the independent contribution of the angiotensinogen M235T mutation to the development of ...
Rossi Gian Paolo - - 2006
OBJECTIVES: This study sought to investigate the impact of a common T(-786)C single-nucleotide polymorphism (SNP) in the promoter of the endothelial nitric oxide synthase (eNOS, NOS3) gene on cardiovascular (CV) death in a prospective cohort study. BACKGROUND: The T(-786)C SNP eNOS gene implies a blunted endothelium-dependent vasodilation in hypertensive patients ...
Ramtahal, Jason
We report a case of a 40 year old female patient who presents with chest pain and is diagnosed with a inferior myocardial infarction (MI) and when tested she was found to be heterozygous (C677T) for Methylene Tetrahydrofolate Reductase (MTHFR) gene mutation. The patient was stopped from using the OCP ...
Oyati, A. I.
Myocardial infarction is thought to be rare in Nigerians. This assumption may not be tenable any longer. We report 4 cases of acute myocardial infarction within one year out of which 3 were Nigerians. This seemingly increasing incidence may not be unconnected with the increase in the number of trained ...
Doggen Carine J M - - 2006
The role of the intrinsic coagulation system on the risk of myocardial infarction is unclear. In the Study of Myocardial Infarctions Leiden (SMILE) that included 560 men younger than age 70 with a first myocardial infarction and 646 control subjects, we investigated the risk of myocardial infarction for levels of ...
Liu Ping-Yen - - 2006
Matrix metalloproteinase-3 (MMP-3) degrades the extracellular matrix and may contribute to the weakening of the plaque cap. To determine whether genotype-phenotype associations differed in different categories of acute coronary syndrome, we enrolled 650 consecutive Taiwanese patients diagnosed with acute coronary syndrome. Genotypic analysis was done on DNA using polymerase chain ...
Yamada Yoshiji - - 2006
Although lifestyle and environmental factors influence the prevalence of myocardial infarction, genetic epidemiological studies have suggested that several genetic variants increase the risk for this condition. We have performed a large-scale association study to identify gene polymorphisms for reliable assessment of the genetic risk of myocardial infarction. The study population ...
Collins Richard P - - 2006
BACKGROUND: The AMPD1 gene C34T polymorphism has previously been associated with prolonged survival in small cohorts of heart failure (HF) and coronary artery disease patients. This study aimed to corroborate the association of the AMPD1 C34T polymorphism with survival in larger myocardial infarction (MI) and HF cohorts. METHODS: Genotypes were ...
Takeuchi Masaaki - - 2006
Atherosclerosis is a diffuse process and can be evaluated in the distal part of the left anterior descending coronary artery (LAD). We evaluated whether 2-dimensional high-frequency transthoracic echocardiography could detect changes in coronary wall thickness and size associated with coronary risk factors. In all, 312 patients without a history of ...
Culić Viktor - - 2007
Increased knowledge concerning the triggering of acute cardiovascular diseases has yielded a change in philosophical approach to this field. During the last decade, clinical evidence suggested that the term acute risk factors can be used for the activities and events that suddenly and transiently increase the risk of acute cardiac ...
Erzen Barbara - - 2007
BACKGROUND: The estimation of coronary risk based on consideration of classical risk factors is insufficient in young patients with myocardial infarction who have low expressions of classical risk factors. Endothelial dysfunction (ED) and markers of vascular inflammation may be more appropriate for risk estimation. The relations among ED and inflammation ...
Ozaki Kouichi - - 2006
Inflammation is now considered critical in the pathogenesis of myocardial infarction. One of the mechanisms regulating the inflammatory process is the ubiquitin-proteasome system. We investigated whether variants of the 20S proteasome are associated with susceptibility to myocardial infarction and found a common SNP (minor allele frequency of 0.35) in the ...
Podgoreanu M V - - 2006
The inflammatory response triggered by cardiac surgery with cardiopulmonary bypass (CPB) is a primary mechanism in the pathogenesis of postoperative myocardial infarction (PMI), a multifactorial disorder with significant inter-patient variability poorly predicted by clinical and procedural factors. We tested the hypothesis that candidate gene polymorphisms in inflammatory pathways contribute to ...
Robert Clarke
Lymphotoxin-α (LTA) is a pro-inflammatory cytokine that plays an important role in the immune system and local inflammatory response. LTA is expressed in atherosclerotic plaques and has been implicated in the pathogenesis of atherosclerosis and coronary heart disease (CHD). Polymorphisms in the gene encoding lymphotoxin-α (LTA) on Chromosome 6p21 have ...
Pezzano Antonio - - 2006
In advanced countries the incidence of cardiovascular diseases is constantly increasing. During the last century many resources were employed to investigate atherosclerosis in relation to the main risk factors and to modification of lifestyles. Technologies have been developed to identify atherosclerosis in the sub-clinical phase. Measurement of the carotid intima-media ...
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