Search Results
Results 451 - 500 of 1453
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Boodhwani Munir - - 2006
Despite improvements in its medical and surgical management, ischemic coronary disease remains responsible for significant morbidity, mortality, and economic burden in developed nations. Therapeutic myocardial angiogenesis is an attractive treatment option for patients with end-stage coronary disease who have failed percutaneous and surgical methods of revascularization. Over the past decade, ...
Skala Judith A - - 2006
OBJECTIVE: Both behavioural and physiological factors have been proposed as mechanisms that may explain the negative effect of depression on coronary heart disease (CHD). Our aim is to review some of the most important findings since our prior review. METHOD: We searched MEDLINE, PsycINFO, and other sources for recent studies ...
Yende Sachin - - 2006
PURPOSE OF REVIEW: Interest in the genetic determinants of complications of cardiovascular disease, and the resultant influence on management, has increased. We have therefore reviewed the literature in the last 12-16 months for studies documenting genetic risk of complications. The focus is on risk of complications or differences in management, ...
Pasalić Daria - - 2006
This study was performed to assess the effect of the S447X and Hind III lipoprotein lipase gene polymorphisms on development of coronary artery disease and hypertriglyceridemia. The study included 132 patients and 98 healthy control subjects of Croatian descent. The lipoprotein lipase S447X polymorphism was associated with coronary artery disease ...
García-Palmieri Mario R - - 2006
Eighty percent of coronary deaths occur in people above 65 years of age. Fifty percent of deaths in persons above 85 years of age is due to coronary artery disease. The overall aging of the population and the improvement in survival of patients with coronary artery disease has been creating ...
Gurfinkel Enrique P - - 2006
PURPOSE OF REVIEW: There is an enormous literature on the prevention of myocardial infarction. However, most articles are focused categorically on evidence-based medicine and give no room for conceptual analyses. In this article, we attempt to review the main aspects of this theme from a different point of view. RECENT ...
Myśliwska Jolanta - - 2006
IL6 gene promoter polymorphisms may influence the outcome of cardiovascular diseases. The aim of our study was to find out whether the -174G>C polymorphism, as well as the IL6 secretory profile, may be linked to the number of severely (> or = 75%) occluded coronary arteries in patients with advanced ...
Ryan Ronan - - 2006
BACKGROUND: Genes in the class III region of the MHC, encoding proteins involved in inflammation and vascular regulation, were investigated for association with the occurrence of vasodilation and requirement for vasopressor infusion. METHODS: A cohort of 236 elective cardiac surgical patients was studied. Hemodynamic and metabolic variables and dosage of ...
Goldenberg Ilan - - 2006
The M235T mutation of the human angiotensinogen gene has been shown to be associated with elevated circulating angiotensinogen concentrations and essential hypertension. The frequencies of the 235T allele are significantly different in black and white subjects. We analyzed the independent contribution of the angiotensinogen M235T mutation to the development of ...
Rossi Gian Paolo - - 2006
OBJECTIVES: This study sought to investigate the impact of a common T(-786)C single-nucleotide polymorphism (SNP) in the promoter of the endothelial nitric oxide synthase (eNOS, NOS3) gene on cardiovascular (CV) death in a prospective cohort study. BACKGROUND: The T(-786)C SNP eNOS gene implies a blunted endothelium-dependent vasodilation in hypertensive patients ...
Ramtahal, Jason
We report a case of a 40 year old female patient who presents with chest pain and is diagnosed with a inferior myocardial infarction (MI) and when tested she was found to be heterozygous (C677T) for Methylene Tetrahydrofolate Reductase (MTHFR) gene mutation. The patient was stopped from using the OCP ...
Oyati, A. I.
Myocardial infarction is thought to be rare in Nigerians. This assumption may not be tenable any longer. We report 4 cases of acute myocardial infarction within one year out of which 3 were Nigerians. This seemingly increasing incidence may not be unconnected with the increase in the number of trained ...
Doggen Carine J M - - 2006
The role of the intrinsic coagulation system on the risk of myocardial infarction is unclear. In the Study of Myocardial Infarctions Leiden (SMILE) that included 560 men younger than age 70 with a first myocardial infarction and 646 control subjects, we investigated the risk of myocardial infarction for levels of ...
Liu Ping-Yen - - 2006
Matrix metalloproteinase-3 (MMP-3) degrades the extracellular matrix and may contribute to the weakening of the plaque cap. To determine whether genotype-phenotype associations differed in different categories of acute coronary syndrome, we enrolled 650 consecutive Taiwanese patients diagnosed with acute coronary syndrome. Genotypic analysis was done on DNA using polymerase chain ...
Yamada Yoshiji - - 2006
Although lifestyle and environmental factors influence the prevalence of myocardial infarction, genetic epidemiological studies have suggested that several genetic variants increase the risk for this condition. We have performed a large-scale association study to identify gene polymorphisms for reliable assessment of the genetic risk of myocardial infarction. The study population ...
Collins Richard P - - 2006
BACKGROUND: The AMPD1 gene C34T polymorphism has previously been associated with prolonged survival in small cohorts of heart failure (HF) and coronary artery disease patients. This study aimed to corroborate the association of the AMPD1 C34T polymorphism with survival in larger myocardial infarction (MI) and HF cohorts. METHODS: Genotypes were ...
Takeuchi Masaaki - - 2006
Atherosclerosis is a diffuse process and can be evaluated in the distal part of the left anterior descending coronary artery (LAD). We evaluated whether 2-dimensional high-frequency transthoracic echocardiography could detect changes in coronary wall thickness and size associated with coronary risk factors. In all, 312 patients without a history of ...
Culić Viktor - - 2007
Increased knowledge concerning the triggering of acute cardiovascular diseases has yielded a change in philosophical approach to this field. During the last decade, clinical evidence suggested that the term acute risk factors can be used for the activities and events that suddenly and transiently increase the risk of acute cardiac ...
Erzen Barbara - - 2007
BACKGROUND: The estimation of coronary risk based on consideration of classical risk factors is insufficient in young patients with myocardial infarction who have low expressions of classical risk factors. Endothelial dysfunction (ED) and markers of vascular inflammation may be more appropriate for risk estimation. The relations among ED and inflammation ...
Ozaki Kouichi - - 2006
Inflammation is now considered critical in the pathogenesis of myocardial infarction. One of the mechanisms regulating the inflammatory process is the ubiquitin-proteasome system. We investigated whether variants of the 20S proteasome are associated with susceptibility to myocardial infarction and found a common SNP (minor allele frequency of 0.35) in the ...
Podgoreanu M V MV Department of Anesthesiology, Box 3094, Duke University Medical Center, Durham, NC 27710, USA. - - 2006
The inflammatory response triggered by cardiac surgery with cardiopulmonary bypass (CPB) is a primary mechanism in the pathogenesis of postoperative myocardial infarction (PMI), a multifactorial disorder with significant inter-patient variability poorly predicted by clinical and procedural factors. We tested the hypothesis that candidate gene polymorphisms in inflammatory pathways contribute to ...
Robert Clarke
Lymphotoxin-α (LTA) is a pro-inflammatory cytokine that plays an important role in the immune system and local inflammatory response. LTA is expressed in atherosclerotic plaques and has been implicated in the pathogenesis of atherosclerosis and coronary heart disease (CHD). Polymorphisms in the gene encoding lymphotoxin-α (LTA) on Chromosome 6p21 have ...
Pezzano Antonio - - 2006
In advanced countries the incidence of cardiovascular diseases is constantly increasing. During the last century many resources were employed to investigate atherosclerosis in relation to the main risk factors and to modification of lifestyles. Technologies have been developed to identify atherosclerosis in the sub-clinical phase. Measurement of the carotid intima-media ...
Loew Michael - - 2006
BACKGROUND: Both angiotensin-converting enzyme genotype and plasminogen activator inhibitor type 1 genotype have an effect on fibrinolytic components and hence, may increase risk or advance occurrence of coronary heart disease. We examined the association of the angiotensin-converting enzyme and the plasminogen activator inhibitor type 1 genotypes, and their combinations, with ...
Tsukamoto Takahiro - - 2006
PURPOSE: Myocardial flow reserve (MFR) measurement has an important role in assessing the functional severity of coronary artery stenosis. However, a discrepancy between the anatomical severity of coronary artery stenosis and MFR is often observed. Such a discrepancy may be explained by coronary risk factors. In this study, we aimed ...
Zee Robert Y L - - 2006
BACKGROUND AND PURPOSE: Recent findings of an association between polymorphisms of advanced glycosylation end product-specific receptor (AGER) and risk of diabetic vasculopathy have generated great interest. However, to date, no genetic-epidemiological data are available on risk of atherothrombotic events among nondiabetic populations. METHODS: Using DNA samples collected at baseline in ...
Zaroff Jonathan G JG Department of Medicine, University of California, San Francisco, USA. - - 2006
Cardiac abnormalities occur commonly after subarachnoid hemorrhage (SAH) and may be caused by excessive release of catecholamines from the myocardial sympathetic nerves. We hypothesized that adrenoceptor polymorphisms resulting in greater catecholamine sensitivity would be associated with an increased risk of cardiac injury. This was a prospective cohort study. The primary ...
Zwicker Jeffrey I - - 2006
The N700S polymorphism of thrombospondin-1 (TSP-1) has been identified as a potential genetic risk factor for myocardial infarction (MI). In a large case-control study of 1425 individuals who survived a myocardial infarction prior to age 45, the N700S polymorphism was a significant risk factor for myocardial infarction in both homozygous ...
Erzen Barbara - - 2006
OBJECTIVE: We investigated inflammation markers in young post-myocardial infarction patients exhibiting various expressions of classical risk factors. METHODS: Forty-one male patients with high (n=20) and low (n=21) expression of classical risk factors (risk of coronary events calculated by the prospective cardiovascular Munster study program high or low, respectively), on average ...
Liu P-Y - - 2006
BACKGROUND: Oxidation of low density lipoproteins is an initial step of atherogenesis that generates pro-inflammatory phospholipids, including platelet-activating factor (PAF). PAF is degraded by PAF-acetylhydrolase (PAF-AH), which has been postulated to be a risk factor for myocardial infarction (MI). The role of PAF-AH for the onset of premature MI is ...
Brink Eva - - 2007
A short health complaints measure may provide information on the degree of recovery from acute myocardial infarction. The present study therefore evaluated a questionnaire-called the Somatic Health Complaints Questionnaire (SHCQ)-that includes 13 items concerning health problems common in cardiac patients. The sample included 114 patients in total, 37 women and ...
Gottsäter A - - 2006
OBJECTIVE: To review the best medical management of critical limb ischaemia (CLI). METHODS: Published studies dealing with CLI and risk factors were searched for via PUBMED. FINDINGS AND CONCLUSIONS: Patients with critical limb ischaemia (CLI) have a one and ten year mortality of approximately 20% and 75% respectively. Risk factors ...
Nicholls Stephen J - - 2006
OBJECTIVES: The goal of this study was to determine the relationship between established cardiovascular risk factors and the extent of coronary atherosclerotic plaque. BACKGROUND: Few data exist correlating cardiovascular risk factors with volumetric measurements of coronary atheroma burden in patients with coronary artery disease. METHODS: Clinical characteristics, quantitative coronary angiography, ...
Egi Yasuo - - 2006
We attempted to clarify the pathogenesis of gastric inflammation in the cardia. Eighty Japanese participated in this study. Biopsy specimens of the gastric antrum, corpus, and cardia (1 cm from the squamocolumnar junction) were obtained, and histological gastritis was evaluated. Cardiac inflammation was also evaluated using magnifying gastroscopy. We examined ...
Musicant Scott E - - 2006
Elevated levels of C-reactive protein (CRP) and D-dimer (DD) have been associated with the presence and progression of various forms of atherosclerotic disease, particularly coronary heart disease. We hypothesize that there is a relationship between elevated levels of baseline CRP and DD and progression of peripheral arterial disease (PAD) in ...
Zanella Maria Teresa - - 2006
Weight loss improves metabolic abnormalities and reduces cardiovascular risk in obese hypertensive patients. To evaluate the impact of a sustained weight loss on coronary risk, 181 hypertensive patients with metabolic syndrome underwent to orlistat therapy, 120 mg, t.i.d., plus diet for 36 weeks. During therapy, Framingham risk scores (FRS) were ...
Danelia M - - 2006
In Georgia, like the other post soviet republics CHD morbidity is increasing, especially among young and middle aged people i.e. among those who should have the most working ability that points at both individual and social significance of the problem. CHD is becoming more and more common among rural inhabitants, ...
Quist-Paulsen Petter - - 2006
BACKGROUND: Smoking cessation is probably the most important action to reduce mortality after a coronary event. Smoking cessation programs are not widely implemented in patients with coronary heart disease, however, possibly because they are thought not to be worth their costs. Our objectives were to estimate the cost effectiveness of ...
Sjauw Krischan Daniël - - 2006
Most risk-stratification instruments that have been developed to predict outcome after myocardial infarction do not make use of laboratory parameters, although several laboratory parameters have been shown to be predictors of adverse outcome. To assess the prognostic value of routine admission laboratory tests, we studied a sample of 264 of ...
Koch Werner - - 2006
OBJECTIVE: Transforming growth factor (TGF)-beta1 (TGF-beta1) is a multifunctional cytokine that exhibits vasculoprotective properties. Production and plasma levels of TGF-beta1 are influenced by polymorphisms in the TGF-beta1 gene (TGFB1). We investigated whether the -509C/T (rs1800469), 868T/C (rs1982073), 913G/C (rs1800471), and 11929C/T (rs1800472) polymorphisms of TGFB1 are associated with myocardial infarction. ...
Hancer Veysel Sabri - - 2006
BACKGROUND: Activated factor XIII (FXIII) cross-links between fibrin monomers, thus increasing the clot stability and resistance to fibrinolysis. Congenital FXIII deficiency causes severe bleeding diathesis. Recently, a common polymorphism of the FXIII A subunit (FXIII Val34Leu) has been identified as a protective factor against both arterial and venous thrombosis. The ...
Jurkovicova D - - 2006
Apolipoprotein E (ApoE) is 34 kDa protein involved in the modulation of cholesterol transport and homeostasis. Polymorphism of the ApoE gene has been implicated in many chronic cardiovascular and neuronal diseases. ApoE epsilon4 allele has been reported to be associated with increased risk of cardiovascular diseases such as myocardial infarction, ...
Hindorff Lucia A - - 2006
Genetic variants in coagulation factors are associated with myocardial infarction and may modify the association between hormone therapy and cardiovascular disease risk. This study assessed whether common variation in the prothrombin gene was associated with incident nonfatal myocardial infarction in postmenopausal women and whether this association differed according to current ...
Quist-Paulsen Petter - - 2006
OBJECTIVE: To evaluate whether smoking cessation after a coronary event improves quality of life, and to assess whether quality of life is a predictor of smoking cessation. DESIGN: Health-related quality of life at baseline and at 12 months follow up were measured in a randomised smoking cessation trial of 240 ...
Ramanathan P Kasi - - 2006
BACKGROUND, In patients with acute coronary syndrome, smoking cessation rates, demographics, and management strategies havenot been well described. We hypothesized that hospitalized patients with acute coronary syndrome would have higher smoking cessation rates than other currently available therapies. In-hospital counseling and referral to cardiac rehabilitation may further improve cessation rates. ...
Wiwanitkit Viroj - - 2006
Platelet glycoprotein (GP) IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor. There is considerable controversy regarding the clinical role of the GPIIb/IIIa PIA1/A2 as a risk factor for myocardial infarction. A summative analysis is performed on the recent previous reports on the GPIIb/IIIa PIA1/A2 and its correlation ...
Taylor Allen J - - 2006
The authors examined the relationship between calcified coronary atherosclerosis and an array of cardiovascular risk factors in sequential logistic models to determine the extent to which these markers overlap in their identification of patients at risk for developing coronary heart disease. The prevalence of coronary artery calcium using electron beam ...
Baum Larry - - 2006
BACKGROUND: Because apolipoprotein E (apoE) and lipopoprotein lipase (LPL) polymorphisms interact with each other and with other factors to affect lipid metabolism, we sought to determine their separate and combined effects in association with ischemic vascular disease. METHODS: We performed a case-control study of 816 subjects: 246 acute ischemic stroke ...
Hernesniemi J - - 2006
OBJECTIVE: Atherosclerosis is considered to be a chronic inflammatory disease. Toll-like receptor 4 (TLR-4), a key mediator in activating inflammatory cascade, has an A-to-G functional polymorphism that changes aspartic acid to glycine at position 299. TLR-4 is activated by, for example, lipopolysaccharides. The purpose of this study was to investigate ...
Zhang Liyun - - 2006
The association between atrial natriuretic peptide (ANP) polymorphism and coronary heart disease (CHD) was studied in Chinese population. The genotypes of ANP T2238C and ANP C-664G were detected by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods in 158 consecutive CHD patients and 165 controls. It was found ...
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