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Prodanov Petko P Cardiocenter, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Srobarova 50 str., 100 34, Prague 10, Czech Republic, - - 2014
We briefly and comprehensively present some of the novel findings in the field of revascularization therapy and management of ST-segment-elevation myocardial infarction (STEMI). We highlight the latest evidence-based advancements in the pharmacological and mechanical treatment of patients who presented with STEMI. Since the last updates to the international guidelines (American ...
Kusmic Claudia - - 2014
Up-regulation of HO-1 by genetic manipulation or pharmacological pre-treatment has been reported to provide benefits in several animal models of myocardial infarction (MI). However, its efficacy following MI initiation (as in clinical reality) remains to be tested. Therefore, this study investigated whether HO-1 over-expression, by cobalt protoporphyrin (CoPP) administered after ...
Bergh Niklas N Department of Cardiology, Sahlgrenska University Hospital , Göteborg , - - 2014
Background: Intra-aortic balloon pump (IABP) counterpulsation and primary percutaneous coronary intervention (PCI) are standard treatment modalities in cardiogenic shock (CS) complicating acute myocardial infarction. The aim of this study was to investigate the impact of the timing of IABP treatment start in relation to PCI procedure. Methods: Data were obtained ...
Schoos Mikkel Malby MM The Zena and Michael A. Wiener Cardiovascular Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, - - 2014
To review the presentation, diagnosis and recent developments in the pharmacological and invasive treatment of ST elevation myocardial infarction (STEMI) with a special focus on health-care organization in order to increase accessibility of primary percutaneous coronary intervention (PCI). Data were obtained from English publications on STEMI treatment. No formal systematic ...
Malz Ronny R Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Centrum für Herz- und Kreislaufmedizin, Medizinische Klinik II, 12200, Berlin, - - 2014
Myocarditis is induced by coxsackievirus B3 (CVB3). Myocardial inflammation is tied to the activation of coagulation. Coagulation factor (F) Xa, a central player in coagulation, activates matrix metalloproteinases (MMP), which modulate the remodeling. In this study, we investigated the effects of pharmacological FXa inhibition on myocardial function, inflammation and remodeling ...
Laing Craig C Craig Laing is a nurse practitioner at Christiana Care Cardiology Consultants, Christiana Care Health System, Newark, - - 2014
: Heart failure affects more than 5 million Americans with approximately 200,000 patients in end-stage disease that has failed traditional treatment. Historically, the only option for treatment was a heart transplant until left ventricular assist devices offered another option.
Lucisano L L Department of Cardiovascular Respiratory, Nephrologic Anesthesiologic and Geriatric Sciences Umberto I Hospital "Sapienza" University, Rome, Italy - - - 2014
Since the advent of coronary angioplasty the treatment of bifurcation lesions has always proved a complex issue resulting in lower angiographic success rates, increased risk of restenosis, higher rates of dissection, myocardial infarction, and acute vessel closure. The advent of coronary stenting reduced the risks, but in-stent restenosis was noted ...
Walsh Joseph A JA 3rd Division of Cardiovascular Diseases, Scripps Clinic , 10666 North Torrey Pines Road, Maildrop S1056, La Jolla, CA 92037 , USA +1 858 554 5032 ; +1 858 554 6883 ; - - 2014
Introduction: Percutaneous coronary intervention (PCI) is a highly effective treatment for obstructive coronary artery disease. Oral platelet P2Y12 receptor antagonists reduce ischemic events in patients treated with PCI. However, there are several limitations to their use, including variable pharmacodynamics, a slow onset and offset, and in those patients who are ...
Kenia Anand S AS Department of Medicine, Thomas Jefferson University Hospital, - - 2014
A 46-year-old woman was brought to the electrophysiology laboratory for ablative treatment of highly symptomatic, frequently recurring, ECG documented mid-RP narrow complex tachycardia. This article is protected by copyright. All rights reserved.
Pande Ashvin N AN Boston Medical Center, Boston, - - 2014
The clinical benefit of reducing the time between the onset of ST-segment elevation myocardial infarction (STEMI) and coronary reperfusion has been a motivating principle for cardiologists and their emergency care colleagues for the past two decades(1). Prompt treatment with fibrinolytic therapy or primary percutaneous coronary intervention (PCI) leads to improved ...
Mårtensson Solvej S Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, - - 2014
To investigate trends in time to invasive examination and treatment for patient with first time diagnosis of non-ST elevation myocardial infarction (NSTEMI) and unstable angina during the period from 2001 to 2009 in Denmark. From 1 January 2001 to 31 December 2009 all first time hospitalisations with NSTEMI and unstable ...
Fu Shu-Ping SP Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, - - 2014
Acupuncture exerts cardioprotective effects on several types of cardiac injuries, especially myocardial ischemia (MI), but the mechanisms have not yet been well elucidated. Angiogenesis mediated by VEGF gene expression and its modification through histone acetylation has been considered a target in treating myocardial ischemia. This study aims to exam whether ...
Delk K W KW Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, - - 2013
A one-year-old African pygmy hedgehog (Atelerix albiventris) was evaluated for severe respiratory distress. Physical examination findings included marked dyspnoea, cyanosis and tachypnoea. Radiographic findings included an enlarged heart and pulmonary oedema, and dilated cardiomyopathy was confirmed via echocardiogram. The patient was treated for congestive heart failure because of dilated cardiomyopathy ...
Risos Lamprini L Department of Cardiology, Erasme Hospital, Université Libre de Bruxelles, Brussels, - - 2013
: Over the past two decades, drug therapy of patients with stable angina pectoris has improved, with a marked impact on the hard clinical outcomes of mortality and myocardial infarction. In contrast, recent trials have not demonstrated beneficial effects of revascularization on mortality. However, in the large trials that compared ...
Lexis Chris P H - - 2013
Increased myocardial infarct (MI) size is associated with higher risk of developing left ventricular dysfunction, heart failure and mortality. Experimental studies have suggested that metformin treatment reduces MI size after induced ischaemia but human data is lacking. We aimed to investigate the effect of metformin on MI size in patients ...
Movahed M R MR CareMore Health Care Arizona, Division of Cardiology The Southern Arizona VA health Care System Tucson, Arizona and Division of Cardiology University of Arizona, Tucson, AZ, USA - - - 2013
Cardiovascular disease remains the leading cause of mortality worldwide. Many deaths are contributed to acute ST elevation myocardial infarction (STEMI). Recently, epidemiological studies have been shown reduction in STEMI related mortality over the last decade. This reduction has partially been attributed to new pharmacological and device advances that were utilized ...
Langabeer James R JR - - 2013
Reducing delays in time to treatment is a key goal of ST-elevation myocardial infarction (STEMI) emergency care. Emergency medical services (EMS) are a critical component of the STEMI chain of survival. We sought to assess the impact of the careful integration of EMS as a strategy for improving systemic treatment ...
Barron Anthony J - - 2013
Antihypertensive treatment can improve tissue Doppler indices of left ventricular diastolic function in the short term, but little is known about the longer-term effect of different antihypertensive treatments on progression of left ventricular diastolic function and left ventricular hypertrophy. We hypothesized that long-term treatment of hypertension will lead to improvements ...
Liu Yu Y Department of Cardiology, Peace Hospital of People's Liberation Army, Shijiazhuang, Hebei, China; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Laboratory of Medical Biotechnology of Hebei Province, Hebei Traditional Chinese Medical College, Shijiazhuang, Hebei, - - 2014
Endoplasmic reticulum (ER) stress plays an important role in mediating ischemic heart cell death. The aim of this study was to investigate whether manipulation of a key factor of the ER stress pathway, eukaryotic translation initiation factor 2 subunit α (eIF2α), can change the natural history of heart failure (HF). ...
Halvorsen S - - 2013
Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI), as long as it can be delivered within 90-120 minutes from patient's first medical contact, and is the leading reperfusion strategy in most European countries. However, as PPCI cannot be offered in a timely manner ...
Dullaghan Lisa - - 2013
Presentations of acute myocardial infarction (MI) can be divided into diagnostic subcategories that require different treatments. This article reports the results of a study that explored and compared patients' perceptions of their illness and motivation for behavioural change after different treatments for MI. Results suggest that patients who have had ...
Rebic Damir - - 2013
Abstract Background: Left ventricular hypertrophy is the most common structural cardiac alteration in chronic dialysis patients. The aim of this study was to determine the possible association of endotelin-1 (ET-1) and nitric oxide (NO) with parameters of echocardiography in order to assess their participation in left ventricular (LV) remodeling in ...
Roubille François - - 2013
Rest is usually recommended in acute pericarditis and acute myocarditis. Given that myocarditis often leads to hospitalization, this task seems easy to carry out in hospital practice; however, it could be a real challenge at home in daily life. Heart rate-lowering treatments (mainly beta-blockers) are usually recommended in case of ...
Nagamoto Yasutsugu - - 2013
A 77-year-old man was referred to our cardiovascular department for detailed examination after abnormal electrocardiography findings were obtained during a preoperative cataract surgery workup. Ultrasound echocardiography (UCG) and computed tomography (CT) revealed evidence of previous myocardial infarction with anteroseptal akinesis and a left ventricular (LV) thrombus (14 × 12 mm). ...
Ferrarello Santo - - 2013
To compare the long-term clinical outcomes of everolimus-eluting (EES) and Resolute zotarolimus-eluting (R-ZES) stents in the treatment of coronary bifurcation lesions. Recent studies have suggested that the R-ZES is comparable to the EES in the treatment of de novo coronary artery disease. Available data on how these compare in the ...
Maximov Georgi Konstantinov - - 2013
Hiccup (Singultus) is a sudden and involuntary contraction of the diaphragm followed by a sharp closure of the epiglottis which results in the production of a specific "hic" sound. Normally, hiccups are treated without intervention. Intractable hiccups occur rarely but are a disturbing symptom underlying other health related disorders. We ...
Braunersreuther V - - 2013
Chemokines trigger leukocyte trafficking and are implicated in cardiovascular disease pathophysiology. Chemokine-binding proteins, called "Evasins" have been shown to inhibit both CC and CXC chemokine-mediated bioactivities. Here, we investigated whether treatment with Evasin-3 (CXC chemokine inhibitor) and Evasin-4 (CC chemokine inhibitor) could influence post-infarction myocardial injury and remodelling. C57Bl/6 mice ...
Fiuzat Mona - - 2013
The complexity of standard medical treatment for heart failure is growing, and such therapy typically involves 5 or more different medications. Given these pressures, there is increasing interest in harnessing cardiovascular biomarkers for clinical application to more effectively guide diagnosis, risk stratification, and therapy. It may be possible to realize ...
Bagai Akshay - - 2013
In the EARLY ACS trial, routine early eptifibatide was not superior to delayed provisional use at percutaneous coronary intervention (PCI); however, among PCI-treated patients, numerically fewer ischemic end points occurred in the upstream eptifibatide group. We sought to further explore this finding using methods for examination of treatment effect in ...
Mao Yuanjie - - 2013
Both ghrelin and the synthetic analogue hexarelin are reported to possess cardioprotective actions that are mainly exerted through different receptors. However, their effects on acute myocardial infarction have not been compared in vivo. This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin knockout mice, ...
Liu Mi - - 2013
Panax quinquefolium saponin (PQS) alleviates hypoxia-reoxygenation injury of cardiomyocytes in vitro by inhibiting excessive endoplasmic reticulum stress (ERS)-related apoptosis. We hypothesized that inhibition of excessive ERS-related apoptosis contributes to cardioprotection in ventricular remodeling following acute myocardial infarction (AMI). Sprague-Dawley (SD) rats subjected to AMI were randomly treated with either water, ...
Tsipouras Markos G - - 2013
This work presents the Treatment Tool, which is a component of the Specialist's Decision Support Framework (SDSS) of the SensorART platform. The SensorART platform focuses on the management of heart failure (HF) patients, which are treated with implantable, left ventricular assist devices (LVADs). SDSS supports the specialists on various decisions ...
Hirschl Michael M - - 2013
Despite the recommendations to initiate β-blockade to all patients with an ST-segment elevation myocardial infarction, data concerning the timing of the administration of β-blockers are controversially discussed. In view of these controversies, we analyzed the effect of immediate vs. delayed β-blockade on all-cause mortality of patients with ST-segment elevation myocardial ...
de La Fuente Rn - - 2013
We evaluated the effects of short-term pyridostigmine bromide (0.14 mg/ml) treatment started early after myocardial infarction (MI) on the left ventricular (LV) and autonomic function of rats. Male Wistar rats were divided into: control, pyridostigmine, infarcted, infarcted+ pyridostigmine. Pyridostigmine treatment in the drink water began immediately after MI or Sham ...
Soekhlal R R - - 2013
This study aimed to calculate the treatment costs of acute myocardial infarction (AMI) in the Netherlands for 2012. Also, the degree of association between treatment costs of AMI and some patient and hospital characteristics was examined. For this retrospective cost analysis, patients were drawn from the database of the Diagnosis ...
van Nunen L X - - 2013
Cornerstones in the treatment of coronary artery disease (CAD) are medical therapy and coronary revascularization. In acute settings (ST-elevation myocardial infarction and non-ST-elevation myocardial infarction), percutaneous coronary intervention (PCI) has proven to improve prognosis. The optimal treatment of stable CAD is subject to great controversy. By using fractional flow reserve ...
Hawkins Nathaniel M - - 2013
Background-Social gradients in cardiovascular mortality across the United Kingdom may reflect differences in incidence, disease severity, or treatment. It is unknown whether a universal healthcare system delivers equitable lifesaving medical therapy for coronary heart disease. We therefore examined secular trends in the use of key medical therapies stratified by socioeconomic ...
Hakacova Nina - - 2013
BACKGROUND: Human herpesvirus 6 (HHV-6) is an important cause of fulminant or acute viral myocarditis. However, insufficiency of standard antiviral treatment against HHV-6 is an emerging problem. OBJECTIVES: To describe the case of child with HHV-6 myocarditis who was treated by unloading with a left ventricular assist device and Artesunate. ...
Bergmeijer Thomas O - - 2013
Providing optimal care to patients with ST-segment elevated myocardial infarction is challenging. If a patient experiences chest pain and calls the emergency number, a cascade of actions is initiated that should lead to a diagnosis, start of treatment and reperfusion of the infarcted myocardium. This should all happen within 90 ...
Ma Shuainan - - 2013
Ischemic cerebral infarction is a leading cause of death and disability, but the key inflammatory cytokines were not fully understood and no successful therapy has been established. We have used the methods of reverse transcriptase-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), western blot, and immunohistochemical staining to detect the ...
Kala Petr - - 2013
Primary percutaneous coronary intervention is the best treatment of patients with ST elevation myocardial infarction (STEMI). When managing a STEMI patient, our approach must be rapid and aggresive in order to interrupt the pathological process of thrombus formation and stabilization. The therapy must be initiated prior to angiography (pretreatment), continued ...
Lee Lik Chuan - - 2013
BACKGROUND: Left ventricular (LV) wall stress reduction is a cornerstone in treating heart failure. Large animal models and computer simulations indicate that adding non-contractile material to the damaged LV wall can potentially reduce myofiber stress. We sought to quantify the effects of a novel implantable hydrogel (Algisyl-LVR™) treatment in combination ...
Kandzari David E - - 2013
OBJECTIVE: To evaluate clinical and angiographic outcomes using a 1.20 mm diameter angioplasty catheter as part of a predilation strategy for coronary lesion treatment. BACKGROUND: Development of an angioplasty catheter with low crossing profile and small balloon diameter represents an opportunity to facilitate percutaneous revascularization of complex coronary disease. METHODS: Clinical ...
Kolettis Theofilos M - - 2013
Ventricular tachyarrhythmias are common consequences of coronary artery disease. During the prehospital phase of acute myocardial infarction (MI), ischemia-induced electrophysiological changes and genetic factors are responsible for their occurrence, but the precise pathophysiologic mechanisms are ill-understood. Primary percutaneous coronary interventions (PCIs) have decreased the incidence of ventricular tachyarrhythmias during subsequent ...
Wong Dennis T L - - 2013
In acute ST-segment elevation myocardial infarction (STEMI), improvement in reperfusion strategies has contributed to improvement in mortality. Nonetheless up to 40-50% of patients who achieve satisfactory epicardial patency do not necessarily achieve patency at the coronary microvascular level, a condition referred to as the 'no-reflow' phenomenon. The 'no-reflow' phenomenon is ...
Chan Michael - - 2013
PURPOSE OF REVIEW: Heart failure is very common in the elderly and there are numerous challenges in diagnosis, prognostication, and treatment. RECENT FINDINGS: Recent studies have provided useful tools to help with the diagnosis and treatment of heart failure in the elderly. Recent studies also show that standard heart failure ...
Curial M - - 2013
Background. Acute Coronary Syndrome (ACS) is a clinical condition encompassing ST Segment Elevation Myocardial Infarction (STEMI), Non-ST Segment Elevation Myocardial Infarction (NSTEMI), and Unstable Angina (UA) and is characterized by ruptured coronary plaque, ischemic stress, and/or myocardial injury. Emergency department (ED) physicians are on the front lines of ACS management. ...
Ennker J - - 2013
Patients with heart failure symptoms due to ischemic cardiomyopathy face a poor prognosis without adequate treatment. In these patients with viable ischemic myocardium, revascularization surgery is not a new but an established treatment concept. the CASS study, published in 1983, was already able to document the superiority of coronary artery revascularization ...
Ondrus Tomas T Department of Internal Medicine and Cardiology, Masaryk University and University Hospital Brno, Brno, Czech - - 2013
Right ventricle myocardial infarctions (RVMIs) accompany inferior wall ischemia in up to one-half of cases. The clinical sequelae of RVMIs vary from no hemodynamic compromise to severe hypotension and cardiogenic shock. Diagnosis is based on physical examination, electrocardiography, echocardiography and coronary angiography. Because the standard 12-lead electrocardiogram is insufficient for ...
Serpytis Pranas P Faculty of Medicine, Vilnius University, Vilnius, Lithuania ; Clinic of Cardiovascular Diseases, Vilnius University Hospital Santariškiu Klinikos, Vilnius, - - 2013
Therapeutic hypothermia is method used to improve the neurological status of patients who are at risk of ischaemia after myocardial infarction. We report a case of a 28-year-old woman who suffered acute myocardial infarction complicated by ventricular fibrillation. The patient was successfully resuscitated. Invasive and non-invasive medical treatment was applied ...
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