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Camm Christian F CF From the Trauma Emergency and Acute Medicine Division, Kings College Hospital, London, - - 2014
Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C) is an inherited cardiomyopathy, characterized by right ventricular dysfunction and ventricular arrhythmias. Premature ventricular contractions (PVCs) are an important measure in determining disease severity and constitute a minor criterion in the 2010 Task Force Criteria for the diagnosis of ARVD/C. Little information is available regarding ...
Burch Druin D Public Library of Science, Cambridge, United - - 2014
Please see later in the article for the Editors' Summary.
Tan Nigel S NS Terrence Donnelly Heart Centre, St. Michael's Hospital, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, - - 2014
Compared with non-smokers, cigarette smokers with ST-segment elevation myocardial infarctions derive greater benefit from fibrinolytic therapy. However, it is not known whether the optimal treatment strategy after fibrinolysis differs on the basis of smoking status. The Trial of Routine Angioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial ...
Lee Leong L Department of Cardiology, City Hospital, Birmingham, - - 2014
Primary percutaneous coronary intervention (PPCI) is the reperfusion treatment of choice for acute ST-elevation myocardial infarction with studies having demonstrated improved outcomes with PPCI over thrombolysis. Its use has increased substantially over the last decade, overtaking thrombolytic therapy in many countries. This has been paralleled with advances in adjunctive technology ...
Lee Lik Chuan LC Department of Mechanical Engineering, Michigan State University, MI, USA. Electronic address: - - 2014
Injection of biomaterials into diseased myocardium has been associated with decreased myofiber stress, restored left ventricular (LV) geometry and improved LV function. However, its exact mechanism(s) of action remained unclear. In this work, we present the first patient-specific computational model of biomaterial injection that accounts for the possibility of residual ...
Tang Yuan Y Department of Biomedical Engineering, Widener University, Chester, PA USA; Department of Mechanical Engineering, Temple University, Philadelphia, PA - - 2014
Rebuilding of infarcted myocardium by mesenchymal stem cells (MSCs) has not been successful because of poor cell survival due in part to insufficient blood supply after myocardial infarction (MI). We hypothesize that targeted delivery of vascular endothelial growth factor (VEGF) to MI can help regenerate vasculature in support of MSC ...
Singh Mrinal M Transplant Unit, Papworth Hospital, Cambridge, - - 2014
Advanced heart failure is a rare but important complication of hypertrophic cardiomyopathy (HCM). The only definitive treatment is heart transplantation and the role of ventricular assist devices remains uncertain. We describe the use of implantable biventricular assist devices in the treatment of a patient with 'end-stage' non-dilated HCM.
Kurrelmeyer Karla M KM Methodist DeBakey Heart and Vascular Center, Houston, TX. Electronic address: - - 2014
Although spironolactone has been shown to decrease morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction , its role in patients with heart failure and preserved left ventricular ejection fraction (HFpEF) is not well defined. In this study we investigate the mechanisms involved when elderly ...
Prodanov Petko P Cardiocenter, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Srobarova 50 str., 100 34, Prague 10, Czech Republic, - - 2014
We briefly and comprehensively present some of the novel findings in the field of revascularization therapy and management of ST-segment-elevation myocardial infarction (STEMI). We highlight the latest evidence-based advancements in the pharmacological and mechanical treatment of patients who presented with STEMI. Since the last updates to the international guidelines (American ...
Bradfield Jason S JS UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Health System, David Geffen School of Medicine at UCLA, Los Angeles, CA, - - 2014
The autonomic nervous system is known to play a significant role in the genesis and persistence of arrhythmias. Neuromodulation has become a new therapeutic strategy for the treatment of ventricular arrhythmias. Catheter-based renal denervation (RDN) is being studied as a treatment option for drug-refractory hypertension. Ablation within the renal arteries, ...
Fantinelli Juliana J Established Investigator of CONICET, Centro de Investigaciones Cardiovasculares, Universidad Nacional de La Plata, La Plata, Buenos Aires, - - 2014
Previous results show that prolonged treatment with EMD-87580 (EMD) NHE-1 blocker attenuates and reverses postinfarction remodelling. Our aim was to evaluate the effects of the treatment of EMD compared to ischemic postconditioning (IPO) in a model of regional ischemia. Isolated hearts were subjected to 40-min coronary occlusion followed by 60-min ...
Khaliulin Igor - - 2014
Consecutive treatment of normal heart with a high dose of isoproterenol and adenosine (Iso/Ade treatment), confers strong protection against ischaemia/reperfusion injury. In preparation for translation of this cardioprotective strategy into clinical practice during heart surgery, we further optimised conditions for this intervention using a clinically-relevant dose of Iso and determined ...
Padilla Pérez Miriam M Cardiology Department, Complejo Hospitalario de Jaén, Jaén, - - 2014
Intracardiac thrombus is a potentially life-threatening condition, with a high risk of embolic complications. Although vitamin K antagonists have been traditionally used for the treatment of intracardiac thrombus, they have relevant disadvantages that limit their use. Rivaroxaban is a once daily oral anticoagulant, currently indicated for the prevention of stroke ...
Kusmic Claudia - - 2014
Up-regulation of HO-1 by genetic manipulation or pharmacological pre-treatment has been reported to provide benefits in several animal models of myocardial infarction (MI). However, its efficacy following MI initiation (as in clinical reality) remains to be tested. Therefore, this study investigated whether HO-1 over-expression, by cobalt protoporphyrin (CoPP) administered after ...
Bergh Niklas N Department of Cardiology, Sahlgrenska University Hospital , Göteborg , - - 2014
Background: Intra-aortic balloon pump (IABP) counterpulsation and primary percutaneous coronary intervention (PCI) are standard treatment modalities in cardiogenic shock (CS) complicating acute myocardial infarction. The aim of this study was to investigate the impact of the timing of IABP treatment start in relation to PCI procedure. Methods: Data were obtained ...
Schoos Mikkel Malby MM The Zena and Michael A. Wiener Cardiovascular Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, - - 2014
To review the presentation, diagnosis and recent developments in the pharmacological and invasive treatment of ST elevation myocardial infarction (STEMI) with a special focus on health-care organization in order to increase accessibility of primary percutaneous coronary intervention (PCI). Data were obtained from English publications on STEMI treatment. No formal systematic ...
Malz Ronny R Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Centrum für Herz- und Kreislaufmedizin, Medizinische Klinik II, 12200, Berlin, - - 2014
Myocarditis is induced by coxsackievirus B3 (CVB3). Myocardial inflammation is tied to the activation of coagulation. Coagulation factor (F) Xa, a central player in coagulation, activates matrix metalloproteinases (MMP), which modulate the remodeling. In this study, we investigated the effects of pharmacological FXa inhibition on myocardial function, inflammation and remodeling ...
Laing Craig C Craig Laing is a nurse practitioner at Christiana Care Cardiology Consultants, Christiana Care Health System, Newark, - - 2014
: Heart failure affects more than 5 million Americans with approximately 200,000 patients in end-stage disease that has failed traditional treatment. Historically, the only option for treatment was a heart transplant until left ventricular assist devices offered another option.
Lucisano L L Department of Cardiovascular Respiratory, Nephrologic Anesthesiologic and Geriatric Sciences Umberto I Hospital "Sapienza" University, Rome, Italy - - - 2014
Since the advent of coronary angioplasty the treatment of bifurcation lesions has always proved a complex issue resulting in lower angiographic success rates, increased risk of restenosis, higher rates of dissection, myocardial infarction, and acute vessel closure. The advent of coronary stenting reduced the risks, but in-stent restenosis was noted ...
Walsh Joseph A JA 3rd Division of Cardiovascular Diseases, Scripps Clinic , 10666 North Torrey Pines Road, Maildrop S1056, La Jolla, CA 92037 , USA +1 858 554 5032 ; +1 858 554 6883 ; - - 2014
Introduction: Percutaneous coronary intervention (PCI) is a highly effective treatment for obstructive coronary artery disease. Oral platelet P2Y12 receptor antagonists reduce ischemic events in patients treated with PCI. However, there are several limitations to their use, including variable pharmacodynamics, a slow onset and offset, and in those patients who are ...
Kenia Anand S AS Department of Medicine, Thomas Jefferson University Hospital, - - 2014
A 46-year-old woman was brought to the electrophysiology laboratory for ablative treatment of highly symptomatic, frequently recurring, ECG documented mid-RP narrow complex tachycardia. This article is protected by copyright. All rights reserved.
Pande Ashvin N AN Boston Medical Center, Boston, - - 2014
The clinical benefit of reducing the time between the onset of ST-segment elevation myocardial infarction (STEMI) and coronary reperfusion has been a motivating principle for cardiologists and their emergency care colleagues for the past two decades(1). Prompt treatment with fibrinolytic therapy or primary percutaneous coronary intervention (PCI) leads to improved ...
Mårtensson Solvej S Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, - - 2014
To investigate trends in time to invasive examination and treatment for patient with first time diagnosis of non-ST elevation myocardial infarction (NSTEMI) and unstable angina during the period from 2001 to 2009 in Denmark. From 1 January 2001 to 31 December 2009 all first time hospitalisations with NSTEMI and unstable ...
Fu Shu-Ping SP Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, - - 2014
Acupuncture exerts cardioprotective effects on several types of cardiac injuries, especially myocardial ischemia (MI), but the mechanisms have not yet been well elucidated. Angiogenesis mediated by VEGF gene expression and its modification through histone acetylation has been considered a target in treating myocardial ischemia. This study aims to exam whether ...
El Messaoudi Saloua S Department of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Cardiology, Radboud University Medical Center, Nijmegen, The - - 2014
Large prospective studies in patients with type 2 diabetes mellitus have demonstrated that metformin treatment improves cardiovascular prognosis, independent of glycemic control. Administration of metformin potently limits infarct size in murine models of myocardial infarction. This study examined, for the first time in humans, whether metformin limits ischemia-reperfusion (IR) injury ...
Ibrahim Michael M National Heart and Lung Institute Imperial College London, Imperial College Road, South Kensington, London, SW7 2AZ - - 2014
Heart failure (HF) is a growing cause of morbidity and mortality globally. All clinical therapies that reduce mortality have been shown to induce reverse remodeling. In this article, we discuss a conceptual approach to the evolving treatment of HF using emerging treatment modalities for the drug-refractory patient. This approach is ...
Komosa Anna A 1 Department of Cardiology, Poznan University of Medical Sciences, Poznan, - - 2014
Antiplatelet drugs play a crucial role in the treatment of patients with myocardial infarction, particularly in association with percutaneous coronary intervention. Their main advantage is the reduction of adverse ischemic incidents and the major disadvantage is the increase in the frequency of hemorrhages. Thus, the choice of appropriate drug depends ...
Sandhu Amneet A Department of Internal Medicine, Division of Cardiovascular Medicine , The University of Colorado , Denver, Colorado , - - 2014
Prior research has shown a transient increase in the incidence of acute myocardial infarction (AMI) after daylight savings time (DST) in the spring as well as a decrease in AMI after returning to standard time in the fall. These findings have not been verified in a broader population and if ...
Delk K W KW Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, - - 2013
A one-year-old African pygmy hedgehog (Atelerix albiventris) was evaluated for severe respiratory distress. Physical examination findings included marked dyspnoea, cyanosis and tachypnoea. Radiographic findings included an enlarged heart and pulmonary oedema, and dilated cardiomyopathy was confirmed via echocardiogram. The patient was treated for congestive heart failure because of dilated cardiomyopathy ...
Risos Lamprini L Department of Cardiology, Erasme Hospital, Université Libre de Bruxelles, Brussels, - - 2013
: Over the past two decades, drug therapy of patients with stable angina pectoris has improved, with a marked impact on the hard clinical outcomes of mortality and myocardial infarction. In contrast, recent trials have not demonstrated beneficial effects of revascularization on mortality. However, in the large trials that compared ...
Lexis Chris P H - - 2013
Increased myocardial infarct (MI) size is associated with higher risk of developing left ventricular dysfunction, heart failure and mortality. Experimental studies have suggested that metformin treatment reduces MI size after induced ischaemia but human data is lacking. We aimed to investigate the effect of metformin on MI size in patients ...
Movahed M R MR CareMore Health Care Arizona, Division of Cardiology The Southern Arizona VA health Care System Tucson, Arizona and Division of Cardiology University of Arizona, Tucson, AZ, USA - - - 2013
Cardiovascular disease remains the leading cause of mortality worldwide. Many deaths are contributed to acute ST elevation myocardial infarction (STEMI). Recently, epidemiological studies have been shown reduction in STEMI related mortality over the last decade. This reduction has partially been attributed to new pharmacological and device advances that were utilized ...
Langabeer James R JR - - 2013
Reducing delays in time to treatment is a key goal of ST-elevation myocardial infarction (STEMI) emergency care. Emergency medical services (EMS) are a critical component of the STEMI chain of survival. We sought to assess the impact of the careful integration of EMS as a strategy for improving systemic treatment ...
Barron Anthony J - - 2013
Antihypertensive treatment can improve tissue Doppler indices of left ventricular diastolic function in the short term, but little is known about the longer-term effect of different antihypertensive treatments on progression of left ventricular diastolic function and left ventricular hypertrophy. We hypothesized that long-term treatment of hypertension will lead to improvements ...
Liu Yu Y Department of Cardiology, Peace Hospital of People's Liberation Army, Shijiazhuang, Hebei, China; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Laboratory of Medical Biotechnology of Hebei Province, Hebei Traditional Chinese Medical College, Shijiazhuang, Hebei, - - 2014
Endoplasmic reticulum (ER) stress plays an important role in mediating ischemic heart cell death. The aim of this study was to investigate whether manipulation of a key factor of the ER stress pathway, eukaryotic translation initiation factor 2 subunit α (eIF2α), can change the natural history of heart failure (HF). ...
Halvorsen S - - 2013
Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI), as long as it can be delivered within 90-120 minutes from patient's first medical contact, and is the leading reperfusion strategy in most European countries. However, as PPCI cannot be offered in a timely manner ...
Dullaghan Lisa - - 2013
Presentations of acute myocardial infarction (MI) can be divided into diagnostic subcategories that require different treatments. This article reports the results of a study that explored and compared patients' perceptions of their illness and motivation for behavioural change after different treatments for MI. Results suggest that patients who have had ...
Rebic Damir - - 2013
Abstract Background: Left ventricular hypertrophy is the most common structural cardiac alteration in chronic dialysis patients. The aim of this study was to determine the possible association of endotelin-1 (ET-1) and nitric oxide (NO) with parameters of echocardiography in order to assess their participation in left ventricular (LV) remodeling in ...
Roubille François - - 2013
Rest is usually recommended in acute pericarditis and acute myocarditis. Given that myocarditis often leads to hospitalization, this task seems easy to carry out in hospital practice; however, it could be a real challenge at home in daily life. Heart rate-lowering treatments (mainly beta-blockers) are usually recommended in case of ...
Nagamoto Yasutsugu - - 2013
A 77-year-old man was referred to our cardiovascular department for detailed examination after abnormal electrocardiography findings were obtained during a preoperative cataract surgery workup. Ultrasound echocardiography (UCG) and computed tomography (CT) revealed evidence of previous myocardial infarction with anteroseptal akinesis and a left ventricular (LV) thrombus (14 × 12 mm). ...
Ferrarello Santo - - 2013
To compare the long-term clinical outcomes of everolimus-eluting (EES) and Resolute zotarolimus-eluting (R-ZES) stents in the treatment of coronary bifurcation lesions. Recent studies have suggested that the R-ZES is comparable to the EES in the treatment of de novo coronary artery disease. Available data on how these compare in the ...
Maximov Georgi Konstantinov - - 2013
Hiccup (Singultus) is a sudden and involuntary contraction of the diaphragm followed by a sharp closure of the epiglottis which results in the production of a specific "hic" sound. Normally, hiccups are treated without intervention. Intractable hiccups occur rarely but are a disturbing symptom underlying other health related disorders. We ...
Braunersreuther V - - 2013
Chemokines trigger leukocyte trafficking and are implicated in cardiovascular disease pathophysiology. Chemokine-binding proteins, called "Evasins" have been shown to inhibit both CC and CXC chemokine-mediated bioactivities. Here, we investigated whether treatment with Evasin-3 (CXC chemokine inhibitor) and Evasin-4 (CC chemokine inhibitor) could influence post-infarction myocardial injury and remodelling. C57Bl/6 mice ...
Fiuzat Mona - - 2013
The complexity of standard medical treatment for heart failure is growing, and such therapy typically involves 5 or more different medications. Given these pressures, there is increasing interest in harnessing cardiovascular biomarkers for clinical application to more effectively guide diagnosis, risk stratification, and therapy. It may be possible to realize ...
Bagai Akshay - - 2013
In the EARLY ACS trial, routine early eptifibatide was not superior to delayed provisional use at percutaneous coronary intervention (PCI); however, among PCI-treated patients, numerically fewer ischemic end points occurred in the upstream eptifibatide group. We sought to further explore this finding using methods for examination of treatment effect in ...
Mao Yuanjie - - 2013
Both ghrelin and the synthetic analogue hexarelin are reported to possess cardioprotective actions that are mainly exerted through different receptors. However, their effects on acute myocardial infarction have not been compared in vivo. This study aimed to clarify whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin knockout mice, ...
Liu Mi - - 2013
Panax quinquefolium saponin (PQS) alleviates hypoxia-reoxygenation injury of cardiomyocytes in vitro by inhibiting excessive endoplasmic reticulum stress (ERS)-related apoptosis. We hypothesized that inhibition of excessive ERS-related apoptosis contributes to cardioprotection in ventricular remodeling following acute myocardial infarction (AMI). Sprague-Dawley (SD) rats subjected to AMI were randomly treated with either water, ...
Tsipouras Markos G - - 2013
This work presents the Treatment Tool, which is a component of the Specialist's Decision Support Framework (SDSS) of the SensorART platform. The SensorART platform focuses on the management of heart failure (HF) patients, which are treated with implantable, left ventricular assist devices (LVADs). SDSS supports the specialists on various decisions ...
Hirschl Michael M - - 2013
Despite the recommendations to initiate β-blockade to all patients with an ST-segment elevation myocardial infarction, data concerning the timing of the administration of β-blockers are controversially discussed. In view of these controversies, we analyzed the effect of immediate vs. delayed β-blockade on all-cause mortality of patients with ST-segment elevation myocardial ...
de La Fuente Rn - - 2013
We evaluated the effects of short-term pyridostigmine bromide (0.14 mg/ml) treatment started early after myocardial infarction (MI) on the left ventricular (LV) and autonomic function of rats. Male Wistar rats were divided into: control, pyridostigmine, infarcted, infarcted+ pyridostigmine. Pyridostigmine treatment in the drink water began immediately after MI or Sham ...
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