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PangonytÄ—, D.
Both myocardial extracellular matrix as a whole and the fibrillar collagen network can alter in response to environmental stimuli such as ischemia. The aim of the study was to evaluate changes of the fibrillar collagen network in chronic ischemic myocardium and in cases of its regional losses. The percentage volume, ...
Bulbul Sen Bilge B Department of Dermatology, Mustafa Kemal University, School of Medicine, Hatay, - - 2014
Psoriasis is an inflammatory disorder, which has been reported to be associated with cardiovascular (CV) risks. Although increased CV risks in psoriasis are well established, there are no data about changes of contraction synchrony in psoriasis. Therefore, we aimed to study the left ventricular (LV) contraction synchrony in patients with ...
Marston Nicholas A NA University of California San Diego, San Diego, CA, - - 2014
The prognostic value of copeptin in acute chest pain is an area of rapid growth and research interest. Copeptin has already established a role in early diagnosis and rule out of acute myocardial infarction, but as its use increases much of the attention has been directed at the prognostic value ...
Storrow Alan B AB Dept. of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN. Electronic address: - - 2014
We investigated absolute and relative cardiac troponin I (TnI) delta changes, optimal sampling protocols, and decision thresholds for early diagnosis of myocardial infarction (MI). Serial cardiac biomarker values demonstrating a rise and/or fall define MI diagnosis; however the magnitude of change, timing, and diagnostic accuracy of absolute versus relative (percentage) ...
Meloni Antonella A CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, Pisa 56124, - - 2014
[Formula: see text] multislice multiecho cardiac magnetic resonance (CMR) allows quantification of the segmental distribution of myocardial iron overload (MIO). We evaluated whether a preferential pattern MIO was preserved between two CMR scans in regularly chelated thalassaemia major (TM) patients. We evaluated prospectively 259 TM patients enrolled in the MIO ...
Owais Khurram K Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, - - 2014
Before clinical manifestation of regurgitation, the tricuspid annulus dilates and flattens when right ventricular dysfunction is potentially reversible. That makes the case for a prophylactic tricuspid annuloplasty even in the absence of significant tricuspid regurgitation. Owing to the appreciation of the favorable prognostic value of tricuspid annuloplasty, the geometry of the normal tricuspid ...
Engels Elien B EB From the Departments of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the - - 2014
Chronic heart failure patients with a left ventricular (LV) conduction delay, mostly due to left bundle branch block (LBBB), generally derive benefit from cardiac resynchronization therapy (CRT). However, 30%-50% of patients do not show a clear response to CRT. We investigated whether T-wave analysis of the ECG can improve patient ...
Russo Cesare C Department of Medicine, Division of Cardiology, Columbia University Medical Center, 630 West 168th Street, New York, NY, 10032, - - 2014
Global longitudinal strain (GLS) assessed by speckle-tracking echocardiography has been proposed as a parameter able to reflect early changes in left ventricular systolic function at a stage when left ventricular ejection fraction (LVEF) is still normal. This study aimed at assessing prevalence and prognostic value of left ventricular systolic dysfunction ...
Cho Iksung I Division of Cardiology, Severance Cardiovascular Hospital and Severance Biomedical Science Institute, Yonsei University College of Medicine, Yonsei University Health System, 250 Seongsanno Seodaemungu, Seoul, South Korea Department of Radiology, NewYork-Presbyterian Hospital and the Weill Cornell Medical College, New York, NY, - - 2014
Prior evidence observed no predictive utility of coronary CT angiography (CCTA) over the coronary artery calcium score (CACS) and the Framingham risk score (FRS), among asymptomatic individuals. Whether the prognostic value of CCTA differs for asymptomatic patients, when stratified by CACS severity, remains unknown. From a 12-centre, 6-country observational registry, ...
Storrow Alan B AB Dept. of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: - - 2014
To compare emergency department TnI serial sampling intervals, determine optimal diagnostic thresholds, and report representative diagnostic performance characteristics for early rule-in and rule-out of MI. We prospectively measured TnI (AccuTnI+3™, Beckman Coulter) at serial time intervals in 1929 subjects with chest pain or equivalent ischemic symptoms suggestive of acute coronary ...
Xia Rui R Molecular Imaging Laboratory, Department of Radiology, West China Hospital, Sichuan University, PR China Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, PR - - 2014
The common T2 mapping is not suitable for the use in rat heart with high heart rate, unless data are acquired in multiple cardiac cycles. To evaluate a simplified T2 mapping method for faster assessment of myocardial edema and area at risk in a rat model of myocardial infarction. The ...
Altekin Refik Emre RE Akdeniz University Faculty of Medicine, Department of Cardiology, Antalya, - - 2014
Cirrhosis is associated with certain abnormalities in left ventricular (LV) structure and function. Two-dimensional speckle-tracking echocardiography (2D-STE) enables a rapid and accurate analysis of regional LV systolic mechanics in the longitudinal, radial and circumferential directions. The aim of this study was to precisely assess the differences among the 3 directions ...
van de Hoef Tim P TP AMC Heart Center, Academic Medical Center - University of Amsterdam, Amsterdam, The - - 2014
Aims: We sought to compare the diagnostic accuracy of basal stenosis resistance index (BSR), instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR) for stenosis-specific myocardial ischaemia identified by means of a combined reference standard of myocardial perfusion scintigraphy and the hyperaemic stenosis resistance index. Methods and results: BSR and ...
Kono Atsushi K AK Department of Radiology, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan, - - 2014
To evaluate the details of myocardial dysfunction in dilated cardiomyopathy (DCM) patients using tagging images and the correlation of tagging imaging with tissue characteristics. Circumferential strain (Ecc) derived from tagging images was measured in 15 normal (NML) subjects (15 males; mean age 28.5 years) and 12 DCM patients (7 males; mean ...
Fragakis Nikolaos N Third Department of Cardiology, Hippokrateion Hospital, Aristotle University Medical School, Thessaloniki, - - 2014
Currently available agents for pharmacologic management of atrial fibrillation (AF) are limited by their suboptimal efficacy and nonnegligible proarrhythmic risk. Ranolazine (RN) is a novel antianginal agent with increasingly appreciated antiarrhythmic properties that can suppress ventricular and supraventricular arrhythmias including AF. In this review, we describe the electrophysiological properties of ...
Jhamnani Sunny S Department of Medicine, Division of Cardiology, Georgetown University Hospital/Washington Hospital Center, Washington, DC 20010; Department of Medicine, Division of Cardiology, Yale University School of Medicine, New Haven, CT 06520. Electronic address: - - 2014
Descriptions of the significance of ST segment or QRS abnormalities in myocarditis are limited because documentation of the diagnosis has previously required myocardial biopsy. Late gadolinium enhancement (LGE) and T2 weighted imaging in the midventricular wall on cardiac magnetic resonance imaging (CMRI) has a very good positive predictive value for ...
Saxena Pankaj P Department of Cardiothoracic Surgery, The Alfred Hospital, Melbourne, - - 2014
We report our experience with an adolescent patient who required complex management leading to retransplantation for coronary allograft vasculopathy and also review the role of ventricular assist device support in patients with this clinical entity.
Chen Bing-Wei BW State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of - - 2014
The relationship between aortic stiffness and coronary artery disease has been proven. Logistic Clinical SYNTAX score (LogCSS), which combined the anatomical evaluation of coronary artery disease and three clinical factors (age, left ventricular ejection fraction, and creatinine clearance), showed improved predictive value for cardiovascular events in patients after percutaneous coronary ...
Kimura Takeshi T Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan, - - 2014
Percutaneous coronary intervention (PCI) based on fractional flow reserve (FFRcath) measurement during invasive coronary angiography (CAG) results in improved patient outcome and reduced healthcare costs. FFR can now be computed non-invasively from standard coronary CT angiography (cCTA) scans (FFRCT). The purpose of this study is to determine the potential impact ...
Sattur Sudhakar S New York Methodist Hospital, New York, NY, - - 2014
In patients with acute ST-segment elevation myocardial infarction, early, successful, and durable reperfusion therapy optimizes the likelihood of favorable outcomes. Fibrinolysis and primary percutaneous coronary intervention improve survival compared to no reperfusion therapy in large part by reducing infarct size (IS) and preserving left ventricular ejection fraction. There is direct ...
Sharma Kavita K From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, - - 2014
The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the predominant form of HF in the developed world, and soon to reach epidemic proportions. It remains among the most challenging of clinical ...
Khalili Houman H Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, - - 2014
Objective: To conduct a meta-analysis on surrogate and clinical outcomes with myocardial ischemic post-conditioning (IPoC) following revascularization with primary percutaneous intervention (PPCI) for ST-segment myocardial infarction (STEMI) compared with PPCI alone. Background: Reperfusion injury remains an important problem following PPCI for STEMI. Trials of IPoC have mainly focused on cardiac ...
Cho Soo Kyung SK Department of Internal Medicine, Christian Hospital, Gwangju, - - 2014
Stress cardiomyopathy (SCMP) is characterized by a transient left ventricular dysfunction associated with apical ballooning and compensatory hyperkinesias of the basal segments after emotional or physical stress, but inverted or mid-ventricular variants of SCMP have also been described. Although catecholamine excess has been suggested as a possible pathophysiologic mechanism of ...
Arbel Yaron Y Department Cardiology, Tel Aviv Medical Center, Tel Aviv, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: - - 2014
Neutrophil/lymphocyte ratio (NLR) is a novel biomarker that can single out individuals at risk for vascular events. We assessed whether NLR provides additive prognostic value in patients with ST-elevation myocardial infarction (STEMI). NLR was computed from the absolute values of neutrophils and lymphocytes from the complete blood count of patients ...
Wang Yujie Y 1Liaoning Provincial Hospital , Neurology, Shenyang , - - 2014
Abstract Background and Purpose-The clinical and imagine features of different inner border-zone infarct patterns, corona radiate?CR?and centrum semiovale (CSO), is not quiet clear. Both are mostly reported together in previous studies. We intended to observe their clinical and imagine features. Method-We observed 83 patients, 47 cases with CR infarct lesion ...
Doltra Adelina A Thorax Institute, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. - - 2014
Background: The definition of response to cardiac resynchronization therapy (CRT) remains controversial,with variable rates of response depending on the criteria used. Our aim was to analyze the impact of CRT on diastolic function in different degrees of response, particularly in patients with positive clinical but no echocardiographic response.Methods and Results: ...
Sleeper Meg M MM Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA - - 2014
Objective-To generate reference ranges for echocardiographic variables in clinically normal adult chimpanzees (Pan troglodytes). Design-Retrospective cohort study. Animals-88 clinically normal adult chimpanzees. Procedures-Echocardiographic data obtained between 2002 and 2011 from chimpanzees at the Alamogordo Primate Facility were reviewed (263 echocardiograms obtained from 158 individuals). Data from clinically normal individuals (33 ...
Rubanyi Gabor M GM Cardium Therapeutics, San - - 2014
Well developed coronary collateral vessels in patients with symptomatic coronary artery disease (CAD) were shown to be associated with reduced future cardiovascular morbidity and mortality. However, the majority of patients with CAD lack adequate functional coronary collateral circulation. Stimulation of collateral vessel development by angiogenic growth factor therapy (therapeutic angiogenesis,TA) ...
George J J Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee, - - 2014
The renin-angiotensin-aldosterone system (RAAS) is well-established and continues to be pursued as a therapeutic target in the treatment of heart failure, predominantly due to the success of agents that block RAAS in clinical trials of systolic heart failure. The optimal treatment of heart failure patients with preserved ejection fraction (HFpEF), ...
Tariq Sayed M SM Department of Medicine, Albany Medical Center, Albany Medical College, Albany, NY, USA, - - 2014
There is robust epidemiological evidence dating back to the original Framingham Heart Study from 1977 that indicates an important inverse relationship between high-density lipoprotein cholesterol (HDL-C) and risk of incident coronary artery disease (CAD). Despite this body of scientific information demonstrating that low levels of HDL-C are an independent predictor ...
Garcia-Dorado David D Hospital Universitario e Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: - - 2014
Even when reperfusion therapy is applied as early as possible, survival and quality of life are compromised in a considerable number of patients with ST-segment elevation acute myocardial infarction. Some cell death following transient coronary occlusion occurs during reperfusion, due to poor handling of calcium in the sarcoplasmic reticulum-mitochondria system, ...
Schulz Stefanie S German Heart Center Munich, Technical University, Munich, - - 2014
Primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy for patients with ST-segment elevation myocardial infarction (STEMI). Effective and safe adjunct antithrombotic therapy is a major determinant for short- and long-term outcomes after primary PCI. Two separate studies have shown significant benefits vs conventional therapy for 2 recently approved ...
Buchholz Bruno B Department of Pathology, School of Medicine, Institute of Cardiovascular Physiopathology, University of Buenos Aires, JE Uriburu 950 - 2nd Floor, C1114AAD, Buenos Aires, - - 2014
Since ischemic heart disease (IHD) is a major cause of mortality and heart failure, novel therapeutic strategies are expected to improve the clinical outcomes of patients with acute myocardial infarction. Brief episodes of ischemia/reperfusion performed at the onset of reperfusion can reduce infarct size; a phenomenon termed "ischemic postconditioning." Extensive ...
Fedele Francesco F Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, "Sapienza" University of Rome, Policlinico "Umberto I". Electronic address: - - 2014
Staging of heart failure represents a major issue in clinical practice. In this setting, MOGE(S) classification has been designed to be similar to TNM used in oncology. Nevertheless, MOGE(S) nosology is far away from the key elements of TNM classification, as well as simplicity and clinical applicability. In fact, MOGE(S) ...
Srivatsa Sanjay S SS Interventional Cardiology and Electrophysiology, St Agnes Medical Center, Fresno, CA, 93721 USA. - - 2014
Right ventricular septal pacing has been long touted as a more physiologic alternative to right ventricular apical pacing. This article reviews the physiologic and clinical evidence for right ventricular septal versus apical pacing, and presents a novel angiographic technique for efficient attainment of the optimal septal pacing site. The reasons ...
Ozeke Ozcan O Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, - - 2014
It has been rarely encountered some patients in clinical practice with coronary artery chronic total occlusion (CTO) on angiography but no any clinical history or electrocardiographic, echocardiographic, or left ventriculographic evidence of previous myocardial infarction. These noninfarct-related artery CTO (non-IRA CTO) lesions may be used as a clinical role model ...
Coons James C JC University of Pittsburgh School of Pharmacy , 727 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261 , USA +1 412 647 9121, +1 724 449 3943 ; +1 412 647 5847 ; - - 2014
Introduction: Prasugrel is a novel P2Y12 inhibitor approved for treatment of patients with acute coronary syndrome (ACS) who undergo percutaneous coronary intervention (PCI). Areas covered: This article focuses on the pharmacokinetics of prasugrel and recently published pharmacodynamic and clinical studies. The authors searched PubMed and Ovid databases for English language ...
Gao Lei L Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China. - - 2014
The meta-analysis was aimed to compare the long time (>2 year) clinical outcomes of LBS and PES. Limus-based stents (LBS) and paclitaxel-eluting stents (PES) are the two kinds of most common coronary artery stents in clinic. Electronic data bases of PubMed, Cochrane, and EMBASE were searched. We included randomized controlled ...
Louridas George E GE Emeritus Professor of Cardiology, Aristotle University of Thessaloniki, Thessaloniki-Greece. - - 2014
Systems biology is founded on the principles of integrative computational analysis and on the data from genetic and molecular components. The integration of biological components produces interacting networks, modules and phenotypes with remarkable applications in the field of clinical medicine. The evolving concept of network medicine gives a more precise ...
Francis Johnson J Senior Consultant Interventional Cardiologist, Baby Memorial Hospital, Calicut, Kerala 673004, India. Electronic address: - - 2014
It is well established that implantable cardioverter defibrillator (ICD) is a life saving device ensuring protection against life threatening ventricular arrhythmias. But there are certain situations like a recent myocardial infarction where the standard guidelines do not recommend the implantation of an ICD while the patient can still be at ...
Lam Ming Kai MK Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, The - - 2014
To evaluate the safety and efficacy of 2 novel drug-eluting stents (DES) with biodegradable polymer-based coatings versus a durable coating DES. BIO-RESORT is an investigator-initiated, prospective, patient-blinded, randomized multicenter trial in 3540 Dutch all-comers with various clinical syndromes, requiring percutaneous coronary interventions (PCI) with DES implantation. Randomization (stratified for diabetes ...
Demirelli Selami S Department of Cardiology, Erzurum Education and Research Hospital, Erzurum. - - 2014
Although cardiac involvement is rarely seen in Behcet's disease (BD), it is essential to detect subclinical left ventricular (LV) dysfunction for prognostic purposes. Herein we aimed to show the role of two dimensional (2D) speckle tracking echocardiography (STE) in determination of  subclinical LV dysfunction in patients with BD. 30 patients ...
Uhm Jae-Sun JS Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, - - 2013
It is difficult to differentiate the origins of focal atrial tachycardias (ATs) in adjacent structures by electrocardiography (ECG) alone. The aim of this study was to evaluate whether the clinical features of these ATs may help differentiate their origins.METHODS AND RESULTS: One hundred and ninety-four patients (mean age, 43.5 ± ...
Plow Ela B EB Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, ND20, Cleveland, OH, 44195, USA, - - 2013
The last decade has seen a growing interest in adjuvant treatments that synergistically influence mechanisms underlying rehabilitation of paretic upper limb in stroke. One such approach is invasive neurostimulation of spared cortices at the periphery of a lesion. Studies in animals have shown that during training of paretic limb, adjuvant ...
Jolly Sanjit S SS McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada. Electronic address: - - 2014
A major limitation of primary percutaneous coronary intervention (PPCI) for the treatment of ST-elevation myocardial infarction (STEMI) is impaired microvascular perfusion due to embolization and obstruction of microcirculation with thrombus. Manual thrombectomy has the potential to reduce distal embolization and improve microvascular perfusion. Clinical trials have shown mixed results regarding ...
Malliaras Konstantinos K Cedars-Sinai Heart Institute, Los Angeles, California, - - 2014
Cell therapy for heart disease began clinically more than a decade ago. Since then, numerous trials have been performed, but the studies have been underpowered, focusing primarily on low-risk patients with a recent myocardial infarction. Many data have accumulated on surrogate endpoints such as ejection fraction, but few clinical conclusions ...
Doltra A - - 2013
The definition of response to cardiac resynchronization therapy (CRT) remains controversial, with variable rates of response depending on the criteria used. Our aim was to analyze the impact of CRT on diastolic function in different degrees of response, particularly in patients with positive clinical but no echocardiographic response. In 250 ...
Yang Yunjun Y Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, - - 2013
Supratentorial cerebral infarction can cause functional inhibition of remote regions such as the cerebellum, which may be relevant to diaschisis. This phenomenon is often analyzed using positron emission tomography and single photon emission CT. However, these methods are expensive and radioactive. Thus, the present study quantified the changes of infarction ...
Missov Emil - - 2013
Thrombotic complications are inherent to current generation nonpulsatile left ventricular assist devices. The clinical expression of device thrombosis ranges from catastrophic failure to protracted and indolent. We report the case of a 79-year-old patient who received a left ventricular assist device as destination therapy and presented only with vague clinical ...
Nakatani Shimpei - - 2013
Intravascular ultrasound (IVUS) has been clinically available for almost 25 years now and showed us valuable information regarding the coronary vessel lumen, its dimensions, the plaque burden and plaque characteristics that we were not able to assess by angiography alone. Using these abilities, IVUS has helped us to start, understand ...
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