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Coons James C JC University of Pittsburgh School of Pharmacy , 727 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261 , USA +1 412 647 9121, +1 724 449 3943 ; +1 412 647 5847 ; - - 2014
Introduction: Prasugrel is a novel P2Y12 inhibitor approved for treatment of patients with acute coronary syndrome (ACS) who undergo percutaneous coronary intervention (PCI). Areas covered: This article focuses on the pharmacokinetics of prasugrel and recently published pharmacodynamic and clinical studies. The authors searched PubMed and Ovid databases for English language ...
Gao Lei L Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China. - - 2014
The meta-analysis was aimed to compare the long time (>2 year) clinical outcomes of LBS and PES. Limus-based stents (LBS) and paclitaxel-eluting stents (PES) are the two kinds of most common coronary artery stents in clinic. Electronic data bases of PubMed, Cochrane, and EMBASE were searched. We included randomized controlled ...
Louridas George E GE Emeritus Professor of Cardiology, Aristotle University of Thessaloniki, Thessaloniki-Greece. - - 2014
Systems biology is founded on the principles of integrative computational analysis and on the data from genetic and molecular components. The integration of biological components produces interacting networks, modules and phenotypes with remarkable applications in the field of clinical medicine. The evolving concept of network medicine gives a more precise ...
Francis Johnson J Senior Consultant Interventional Cardiologist, Baby Memorial Hospital, Calicut, Kerala 673004, India. Electronic address: - - 2014
It is well established that implantable cardioverter defibrillator (ICD) is a life saving device ensuring protection against life threatening ventricular arrhythmias. But there are certain situations like a recent myocardial infarction where the standard guidelines do not recommend the implantation of an ICD while the patient can still be at ...
Lam Ming Kai MK Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, The - - 2014
To evaluate the safety and efficacy of 2 novel drug-eluting stents (DES) with biodegradable polymer-based coatings versus a durable coating DES. BIO-RESORT is an investigator-initiated, prospective, patient-blinded, randomized multicenter trial in 3540 Dutch all-comers with various clinical syndromes, requiring percutaneous coronary interventions (PCI) with DES implantation. Randomization (stratified for diabetes ...
Demirelli Selami S Department of Cardiology, Erzurum Education and Research Hospital, Erzurum. - - 2014
Although cardiac involvement is rarely seen in Behcet's disease (BD), it is essential to detect subclinical left ventricular (LV) dysfunction for prognostic purposes. Herein we aimed to show the role of two dimensional (2D) speckle tracking echocardiography (STE) in determination of  subclinical LV dysfunction in patients with BD. 30 patients ...
Song Chun-Li CL Department of Cardiology, the Second Hospital of Jilin University, Ziqiang Street No. 218, Nanguan District, Changchun 130000, China. - - 2014
The primary objective of this study investigated the role of microRNA-320 (miR-320) on left ventricular remodeling in the rat model of myocardial ischemia-reperfusion (I/R) injury, and we intended to explore the myocardial mechanism of miR-320-mediated myocardium protection. We collected 120 male Wistar rats (240-280 g) in this study and then ...
Nunes J P L JP Faculdade de Medicina da Universidade do Porto, Portugal ; Department of Cardiology, Hospital Sao Joao, Porto, - - 2014
Diabetes mellitus is associated with cardiovascular disease. Anti-diabetic therapy has a limited capability (if any) of changing the incidence of either death or major cardiovascular disease, and cardiovascular safety concerns have been raised. We aimed at identifying episodes of acute myocardial infarction associated to a relatively new class of drugs, ...
De─čirmenci Hüsnü H Department of Cardiology, Mengücek Gazi Education and Research Hospital, Erzincan University, Erzincan, - - 2014
Background In patients presenting with non-ST elevation myocardial infarction, we investigated the relationship of left atrial deformational parameters evaluated by 2-dimensional speckle tracking imaging (2D-STI) with conventional echocardiographic diastolic dysfunction parameters and brain natriuretic peptide level. Material and Methods We enrolled 74 non-ST segment elevation myocardial infarction patients who were ...
Uhm Jae-Sun JS Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, - - 2013
It is difficult to differentiate the origins of focal atrial tachycardias (ATs) in adjacent structures by electrocardiography (ECG) alone. The aim of this study was to evaluate whether the clinical features of these ATs may help differentiate their origins.METHODS AND RESULTS: One hundred and ninety-four patients (mean age, 43.5 ± ...
Plow Ela B EB Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, ND20, Cleveland, OH, 44195, USA, - - 2013
The last decade has seen a growing interest in adjuvant treatments that synergistically influence mechanisms underlying rehabilitation of paretic upper limb in stroke. One such approach is invasive neurostimulation of spared cortices at the periphery of a lesion. Studies in animals have shown that during training of paretic limb, adjuvant ...
Jolly Sanjit S SS McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada. Electronic address: - - 2014
A major limitation of primary percutaneous coronary intervention (PPCI) for the treatment of ST-elevation myocardial infarction (STEMI) is impaired microvascular perfusion due to embolization and obstruction of microcirculation with thrombus. Manual thrombectomy has the potential to reduce distal embolization and improve microvascular perfusion. Clinical trials have shown mixed results regarding ...
Malliaras Konstantinos K Cedars-Sinai Heart Institute, Los Angeles, California, - - 2014
Cell therapy for heart disease began clinically more than a decade ago. Since then, numerous trials have been performed, but the studies have been underpowered, focusing primarily on low-risk patients with a recent myocardial infarction. Many data have accumulated on surrogate endpoints such as ejection fraction, but few clinical conclusions ...
Doltra A - - 2013
The definition of response to cardiac resynchronization therapy (CRT) remains controversial, with variable rates of response depending on the criteria used. Our aim was to analyze the impact of CRT on diastolic function in different degrees of response, particularly in patients with positive clinical but no echocardiographic response. In 250 ...
Yang Yunjun Y Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, - - 2013
Supratentorial cerebral infarction can cause functional inhibition of remote regions such as the cerebellum, which may be relevant to diaschisis. This phenomenon is often analyzed using positron emission tomography and single photon emission CT. However, these methods are expensive and radioactive. Thus, the present study quantified the changes of infarction ...
Missov Emil - - 2013
Thrombotic complications are inherent to current generation nonpulsatile left ventricular assist devices. The clinical expression of device thrombosis ranges from catastrophic failure to protracted and indolent. We report the case of a 79-year-old patient who received a left ventricular assist device as destination therapy and presented only with vague clinical ...
Nakatani Shimpei - - 2013
Intravascular ultrasound (IVUS) has been clinically available for almost 25 years now and showed us valuable information regarding the coronary vessel lumen, its dimensions, the plaque burden and plaque characteristics that we were not able to assess by angiography alone. Using these abilities, IVUS has helped us to start, understand ...
Grundeken Maik J - - 2013
Coronary bifurcation lesions account for approximately 15% of all percutaneous coronary interventions (PCI) performed. Although clinical outcomes after PCI have been improved considerably, PCI of bifurcation lesions remains to be associated with adverse clinical events, when compared with non-bifurcation PCI. Therefore, several dedicated bifurcation devices have been developed to improve ...
Smulders Martijn W - - 2013
Although high-sensitivity cardiac troponin (hs-cTn) substantially improves the early detection of myocardial injury, it lacks specificity for acute myocardial infarction (MI). In suspected non-ST-elevation MI, invasive coronary angiography (ICA) remains necessary to distinguish between acute MI and noncoronary myocardial disease (eg, myocarditis), unnecessarily subjecting the latter to ICA and associated ...
Moussa Issam D ID Mayo Clinic, Jacksonville, Florida. Electronic address: - - 2013
Numerous definitions have been proposed for the diagnosis of myocardial infarction (MI) after coronary revascularization. The universal definition for MI designates post procedural biomarker thresholds for defining percutaneous coronary intervention (PCI)-related MI (type 4a) and coronary artery bypass grafting (CABG)-related MI (type 5), which are of uncertain prognostic importance. In ...
Moon James C - - 2013
Rapid innovations in cardiovascular magnetic resonance (CMR) now permit the routine acquisition of quantitative measures of myocardial and blood T1 which are key tissue characteristics. These capabilities introduce a new frontier in cardiology, enabling the practitioner/investigator to quantify biologically important myocardial properties that otherwise can be difficult to ascertain clinically. ...
Gutiérrez-Chico J L - - 2013
Percutaneous coronary interventions (PCI) have gained widespread acceptation among cardiologists and among the general population for a variety of clinical indications, comprising from stable angina to ST-elevation acute myocardial infarction, due to the undisputed clinical benefit they provide and to their large availability and accessibility. Nonetheless PCI in the left ...
Vervloet M G - - 2013
Secondary hyperparathyroidism is an almost inevitable complication of advanced kidney failure. The introduction of the calcimimetic cinacalcet for the treatment of secondary hyperparathyroidism in patients on dialysis was based on its ability to reduce elevated levels of parathyroid hormone (PTH). Subsequent clinical studies confirmed the beneficial effects of cinacalcet on ...
Phillips Lawrence M - - 2013
There is a preponderance of evidence that, in the setting of an acute coronary syndrome, an invasive approach using coronary revascularization has a morbidity and mortality benefit. However, recent stable ischemic heart disease (SIHD) randomized clinical trials testing whether the addition of coronary revascularization to guideline-directed medical therapy (GDMT) reduces ...
Thompson Peter L - - 2013
Rupture or erosion of an unstable atherosclerotic plaque is the typical pathology and usual cause of acute coronary syndromes. Despite detailed understanding of the processes of lipid accumulation, thinning of the fibrous cap, and inflammation leading to plaque instability, there are no strategies in clinical use that uniquely target the ...
Szady Anita D AD Division of Cardiovascular Medicine, University of Florida College of Medicine, 1600 S.W. Archer Rd, Gainesville, FL, USA. - - 2013
The purpose of stem cell therapy for myocardial infarction is to improve clinical outcomes, and detailed information on clinical outcomes is critical to appropriate planning of phase III trials. We have examined data from select phase II trials using autologous bone-marrow-derived stem cells in patients with acute myocardial infarction. We ...
Moussa Issam D - - 2013
Numerous definitions have been proposed for the diagnosis of myocardial infarction (MI) after coronary revascularization. The Universal Definition for MI designates post procedural biomarker thresholds for defining percutaneous coronary intervention (PCI)-related MI (type 4a) and coronary artery bypass grafting (CABG)-related MI (type 5) which are of uncertain prognostic importance. In ...
Yadav Mayank - - 2013
The introduction of the SYNTAX score (SS) has prompted a renewed interest for angiographic risk stratification in patients undergoing percutaneous coronary intervention (PCI). The SS is based on qualitative and quantitative characterization of coronary artery disease (CAD) by including 11 angiographic variables that take into consideration lesion location and characteristics. ...
Arsenault Marie - - 2013
-Aortic valve regurgitation (AR) is a volume overload disease causing severe eccentric left ventricular hypertrophy and eventually heart failure. There is currently no approved drug to treat patients with AR. Many vasodilators including angiotensin converting enzyme inhibitors have been evaluated in clinical trials but while some results were promising, others ...
Osnabrugge Ruben Lj - - 2013
The majority (70%) of coronary revascularizations concern patients with multivessel disease (MVD). Treatment options include medical therapy, percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). CABG surgery has been shown to improve survival compared with medical therapy. PCI relieves angina compared with medical therapy and is equivalent to ...
Zannad Faiez - - 2013
Endpoint selection is a critically important step in clinical trial design. It poses major challenges for investigators, regulators, and study sponsors, and it also has important clinical and practical implications for physicians and patients. Clinical outcomes of interest in heart failure trials include all-cause mortality, cause-specific mortality, relevant non-fatal morbidity ...
Hofmann Ulrich U Department of Internal Medicine I, University Hospital Würzburg, Oberdürrbacher Straße 6, 97080, Würzburg, Germany. - - 2013
The prevalence of chronic heart failure is still increasing making it a major health issue in the 21st century. Tremendous evidence has emerged over the past decades that heart failure is associated with a wide array of mechanisms subsumed under the term "inflammation". Based on the great success of immuno-suppressive ...
Bennett Mosi K - - 2013
BACKGROUND: -Endomyocardial biopsy (EMB) is often considered when the etiology of heart failure cannot be determined by non-invasive testing. Uncertainty remains about the diagnostic and clinical utility of EMB in various clinical scenarios. METHODS AND RESULTS: -We examined the characteristics of a cohort of patients with unexplained heart failure who ...
Lee Sangjin - - 2013
The development of ventricular assist devices (VADs) over the past 5 decades as therapy for advanced heart failure (HF) has been extraordinary. Since the original VAD design by Michael DeBakey in the early 1960s, numerous devices for mechanical circulatory support have been engineered, assessed in preclinical studies, applied to human ...
Prinz Christian - - 2013
BACKGROUND: Until now, there is no consensus regarding the definition of a clinical response to cardiac resynchronization therapy (CRT) in patients with chronic heart failure (CHF) and systolic left ventricular (LV) dysfunction. The aim of this study was to evaluate if echocardiography is predictive for an objective improvement in exercise ...
Tojo Hideaki - - 2013
Human chymase, an angiotensin II-forming chymotrypsin-like serine proteinase, posses various biological actions mediating through local angiotensin II formation in the tissue level of many cardiovascular organs. Our previous experimental data have shown that chymase inhibitor increased a survival rate of the hamster post-myocardial infarction model with concomitant improvements of the ...
Woudstra Pier - - 2013
Procedure-related myocardial infarction (pMI) is directly associated with a coronary revascularization procedure, such as percutaneous coronary intervention (PCI) or CABG surgery. In contrast to spontaneous myocardial infarction (MI), the prognostic relevance of pMI is the subject of ongoing debate. Data from retrospective analyses of large, randomized clinical trials, and large, ...
Costa Marco A - - 2013
Left ventricle (LV) remodeling after anterior wall myocardial infarction leads to increased LV volumes, myocardial stress, and, ultimately, heart failure (HF). Patients have high morbidity and mortality risk, and treatment remains limited. Percutaneous ventricular restoration (PVR) therapy using the Parachute device, a fluoropolymer membrane stretched over a nitinol conical frame, ...
Shah Benoy Nalin - - 2013
A very large body of evidence-predominantly retrospective-suggests that revascularization is superior to optimal medical therapy in patients with a significant amount of 'hibernating' myocardium. Contemporary cardiological practice has embraced this standard of practice, as many centres worldwide place great emphasis upon the results of viability testing by non-invasive imaging techniques ...
Biswas Santanu - - 2013
The evaluation of ventricular function is a core component of 2-dimensional echocardiography (2DE). Given the known limitations of 2DE, a more accurate assessment of ventricular function has long been desired. Three-dimensional echocardiography (3DE) holds promise to fulfill this role while maintaining the same benefits of low cost, portability, and efficiency ...
Rubanyi Gabor M GM Cardium Therapeutics, Inc., San Diego, California 92130, USA. - - 2013
Stimulation of collateral vessel development in the heart by angiogenic growth factor therapy has been tested in animals and humans for almost two decades. Discordance between the outcome of preclinical studies and clinical trials pointed to the difficulties of translation from animal models to patients. Lessons learned in this process ...
Mrdovic Igor - - 2013
OBJECTIVES: The present trial aims at examining whether antiplatelet regimen modification, guided by assessment of the on-treatment platelet reactivity, might result with clinical benefit in moderate to high-risk patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). BACKGROUND: High platelet reactivity has been associated with an increased ...
Reddy Pramod - - 2013
ABSTRACT: Left ventricular failure (LVF) is a clinical syndrome caused by abnormal systolic or diastolic function failing to meet the metabolic requirements of the body. It is important to diagnose and manage LVF in the earliest stages to prevent mortality and morbidity. This article extensively reviews the diagnostic, therapeutic, and ...
Menon Venu V Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA. - - 2013
We hypothesized that the insensitivity of the electrocardiogram in identifying acute circumflex occlusion would result in differences in the distribution of the infarct-related artery (IRA) between patients with non-ST-segment elevation myocardial infarction (NSTEMI) and STEMI enrolled in the Occluded Artery Trial. We also sought to evaluate the effect of percutaneous ...
Hausenloy Derek J - - 2013
Coronary heart disease (CHD) is the leading cause of death and disability worldwide. Despite current therapy, the morbidity and mortality for patients with CHD remains significant. The most significant manifestations of CHD arise from acute myocardial ischemia-reperfusion injury (IRI) in terms of cardiomyocyte death and its long-term consequences. As such, ...
Lanza Gaetano A - - 2013
A growing amount of data is increasingly showing the relevance of coronary microvascular dysfunction (CMVD) in several clinical contexts. This article reviews techniques and clinical investigations of the main noninvasive and invasive methods proposed to study coronary microcirculation and to identify CMVD in the presence of normal coronary arteries, also ...
Talan Mark I - - 2013
Extensive research during the last decade demonstrated that a single systemic administration of -erythropoietin (EPO) lead to significant attenuation of myocardial infarction (MI) induced in animals, mostly small rodents, either by a myocardial ischemia followed by reperfusion or by a permanent ligation of a coronary artery. Both methods are critically ...
De Torres-Alba Fernando - - 2013
Coronary artery disease (CAD) and obstructive sleep apnea (OSA) are both complex and significant clinical problems. The pathophysiological mechanisms that link OSA with CAD are complex and can influence the broad spectrum of conditions caused by CAD, from subclinical atherosclerosis to myocardial infarction. OSA remains a significant clinical problem among ...
de Vries Arjen E - - 2013
Although telemonitoring is increasingly used in heart failure care, data on expectations, experiences, and organizational implications concerning telemonitoring are rarely addressed, and the optimal profile of patients who can benefit from telemonitoring has yet to be defined. To assess the actual status of use of telemonitoring and to describe the ...
Smith Rachel Ruckdeschel - - 2013
Cardiosphere-derived cells (CDCs) are under clinical development and are currently being tested in a clinical trial enrolling patients who have undergone a myocardial infarction. CDCs are presently administered via infusion into the infarct-related artery and have been shown in early clinical trials to be effective agents of myocardial regeneration. This ...
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