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Doltra Adelina A Thorax Institute, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. - - 2014
Background: The definition of response to cardiac resynchronization therapy (CRT) remains controversial,with variable rates of response depending on the criteria used. Our aim was to analyze the impact of CRT on diastolic function in different degrees of response, particularly in patients with positive clinical but no echocardiographic response.Methods and Results: ...
Simovic Aleksandra M AM Pediatric Clinic, Clinical Centre Kragujevac, Medical Faculty, University of Belgrade, Serbia; Medical Faculty, University of Kragujevac, Serbia. - - 2014
Severe perinatal asphyxia can cause multiple organ dysfunction and early neonatal mortality. This prospective study was conducted at the Regional University Hospital Neonatology Center in Serbia. The aim of this study was to compare fullterm asphyxiated newborn infants (n=55) with (n=13) and without (n=42) mortality outcome and healthy full-term newborns ...
Sleeper Meg M MM Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA - - 2014
Objective-To generate reference ranges for echocardiographic variables in clinically normal adult chimpanzees (Pan troglodytes). Design-Retrospective cohort study. Animals-88 clinically normal adult chimpanzees. Procedures-Echocardiographic data obtained between 2002 and 2011 from chimpanzees at the Alamogordo Primate Facility were reviewed (263 echocardiograms obtained from 158 individuals). Data from clinically normal individuals (33 ...
Rubanyi Gabor M GM Cardium Therapeutics, San - - 2014
Well developed coronary collateral vessels in patients with symptomatic coronary artery disease (CAD) were shown to be associated with reduced future cardiovascular morbidity and mortality. However, the majority of patients with CAD lack adequate functional coronary collateral circulation. Stimulation of collateral vessel development by angiogenic growth factor therapy (therapeutic angiogenesis,TA) ...
George J J Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee, - - 2014
The renin-angiotensin-aldosterone system (RAAS) is well-established and continues to be pursued as a therapeutic target in the treatment of heart failure, predominantly due to the success of agents that block RAAS in clinical trials of systolic heart failure. The optimal treatment of heart failure patients with preserved ejection fraction (HFpEF), ...
Tariq Sayed M SM Department of Medicine, Albany Medical Center, Albany Medical College, Albany, NY, USA, - - 2014
There is robust epidemiological evidence dating back to the original Framingham Heart Study from 1977 that indicates an important inverse relationship between high-density lipoprotein cholesterol (HDL-C) and risk of incident coronary artery disease (CAD). Despite this body of scientific information demonstrating that low levels of HDL-C are an independent predictor ...
Garcia-Dorado David D Hospital Universitario e Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: - - 2014
Even when reperfusion therapy is applied as early as possible, survival and quality of life are compromised in a considerable number of patients with ST-segment elevation acute myocardial infarction. Some cell death following transient coronary occlusion occurs during reperfusion, due to poor handling of calcium in the sarcoplasmic reticulum-mitochondria system, ...
Schulz Stefanie S German Heart Center Munich, Technical University, Munich, - - 2014
Primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy for patients with ST-segment elevation myocardial infarction (STEMI). Effective and safe adjunct antithrombotic therapy is a major determinant for short- and long-term outcomes after primary PCI. Two separate studies have shown significant benefits vs conventional therapy for 2 recently approved ...
Buchholz Bruno B Department of Pathology, School of Medicine, Institute of Cardiovascular Physiopathology, University of Buenos Aires, JE Uriburu 950 - 2nd Floor, C1114AAD, Buenos Aires, - - 2014
Since ischemic heart disease (IHD) is a major cause of mortality and heart failure, novel therapeutic strategies are expected to improve the clinical outcomes of patients with acute myocardial infarction. Brief episodes of ischemia/reperfusion performed at the onset of reperfusion can reduce infarct size; a phenomenon termed "ischemic postconditioning." Extensive ...
Fedele Francesco F Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, "Sapienza" University of Rome, Policlinico "Umberto I". Electronic address: - - 2014
Staging of heart failure represents a major issue in clinical practice. In this setting, MOGE(S) classification has been designed to be similar to TNM used in oncology. Nevertheless, MOGE(S) nosology is far away from the key elements of TNM classification, as well as simplicity and clinical applicability. In fact, MOGE(S) ...
Srivatsa Sanjay S SS Interventional Cardiology and Electrophysiology, St Agnes Medical Center, Fresno, CA, 93721 USA. - - 2014
Right ventricular septal pacing has been long touted as a more physiologic alternative to right ventricular apical pacing. This article reviews the physiologic and clinical evidence for right ventricular septal versus apical pacing, and presents a novel angiographic technique for efficient attainment of the optimal septal pacing site. The reasons ...
Ozeke Ozcan O Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, - - 2014
It has been rarely encountered some patients in clinical practice with coronary artery chronic total occlusion (CTO) on angiography but no any clinical history or electrocardiographic, echocardiographic, or left ventriculographic evidence of previous myocardial infarction. These noninfarct-related artery CTO (non-IRA CTO) lesions may be used as a clinical role model ...
Coons James C JC University of Pittsburgh School of Pharmacy , 727 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261 , USA +1 412 647 9121, +1 724 449 3943 ; +1 412 647 5847 ; - - 2014
Introduction: Prasugrel is a novel P2Y12 inhibitor approved for treatment of patients with acute coronary syndrome (ACS) who undergo percutaneous coronary intervention (PCI). Areas covered: This article focuses on the pharmacokinetics of prasugrel and recently published pharmacodynamic and clinical studies. The authors searched PubMed and Ovid databases for English language ...
Gao Lei L Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China. - - 2014
The meta-analysis was aimed to compare the long time (>2 year) clinical outcomes of LBS and PES. Limus-based stents (LBS) and paclitaxel-eluting stents (PES) are the two kinds of most common coronary artery stents in clinic. Electronic data bases of PubMed, Cochrane, and EMBASE were searched. We included randomized controlled ...
Louridas George E GE Emeritus Professor of Cardiology, Aristotle University of Thessaloniki, Thessaloniki-Greece. - - 2014
Systems biology is founded on the principles of integrative computational analysis and on the data from genetic and molecular components. The integration of biological components produces interacting networks, modules and phenotypes with remarkable applications in the field of clinical medicine. The evolving concept of network medicine gives a more precise ...
Francis Johnson J Senior Consultant Interventional Cardiologist, Baby Memorial Hospital, Calicut, Kerala 673004, India. Electronic address: - - 2014
It is well established that implantable cardioverter defibrillator (ICD) is a life saving device ensuring protection against life threatening ventricular arrhythmias. But there are certain situations like a recent myocardial infarction where the standard guidelines do not recommend the implantation of an ICD while the patient can still be at ...
Lam Ming Kai MK Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, The - - 2014
To evaluate the safety and efficacy of 2 novel drug-eluting stents (DES) with biodegradable polymer-based coatings versus a durable coating DES. BIO-RESORT is an investigator-initiated, prospective, patient-blinded, randomized multicenter trial in 3540 Dutch all-comers with various clinical syndromes, requiring percutaneous coronary interventions (PCI) with DES implantation. Randomization (stratified for diabetes ...
Demirelli Selami S Department of Cardiology, Erzurum Education and Research Hospital, Erzurum. - - 2014
Although cardiac involvement is rarely seen in Behcet's disease (BD), it is essential to detect subclinical left ventricular (LV) dysfunction for prognostic purposes. Herein we aimed to show the role of two dimensional (2D) speckle tracking echocardiography (STE) in determination of  subclinical LV dysfunction in patients with BD. 30 patients ...
Song Chun-Li CL Department of Cardiology, the Second Hospital of Jilin University, Ziqiang Street No. 218, Nanguan District, Changchun 130000, China. - - 2014
The primary objective of this study investigated the role of microRNA-320 (miR-320) on left ventricular remodeling in the rat model of myocardial ischemia-reperfusion (I/R) injury, and we intended to explore the myocardial mechanism of miR-320-mediated myocardium protection. We collected 120 male Wistar rats (240-280 g) in this study and then ...
Nunes J P L JP Faculdade de Medicina da Universidade do Porto, Portugal ; Department of Cardiology, Hospital Sao Joao, Porto, - - 2014
Diabetes mellitus is associated with cardiovascular disease. Anti-diabetic therapy has a limited capability (if any) of changing the incidence of either death or major cardiovascular disease, and cardiovascular safety concerns have been raised. We aimed at identifying episodes of acute myocardial infarction associated to a relatively new class of drugs, ...
De─čirmenci Hüsnü H Department of Cardiology, Mengücek Gazi Education and Research Hospital, Erzincan University, Erzincan, - - 2014
Background In patients presenting with non-ST elevation myocardial infarction, we investigated the relationship of left atrial deformational parameters evaluated by 2-dimensional speckle tracking imaging (2D-STI) with conventional echocardiographic diastolic dysfunction parameters and brain natriuretic peptide level. Material and Methods We enrolled 74 non-ST segment elevation myocardial infarction patients who were ...
Schellings Dirk A A M DA Department of Cardiology, Isala Klinieken, Zwolle, The Netherlands (D.M.S., A.A., H.S., J.A.H., - - 2014
The Zwolle Risk Score (ZRS) identifies ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PPCI) eligible for early discharge. We aimed to investigate whether baseline N-terminal pro-brain natriuretic peptide (NT-proBNP) is also able to identify these patients and could improve future risk strategies. PPCI patients included in ...
Roselló-Lletí Esther E Cardiocirculatory Unit, Health Research Institute Hospital La Fe, Valencia, - - 2014
Dilated cardiomyopathy (DCM) is a public health problem with no available curative treatment, and mitochondrial dysfunction plays a critical role in its development. The present study is the first to analyze the mitochondrial proteome in cardiac tissue of patients with DCM to identify potential molecular targets for its therapeutic intervention. ...
Uhm Jae-Sun JS Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, - - 2013
It is difficult to differentiate the origins of focal atrial tachycardias (ATs) in adjacent structures by electrocardiography (ECG) alone. The aim of this study was to evaluate whether the clinical features of these ATs may help differentiate their origins.METHODS AND RESULTS: One hundred and ninety-four patients (mean age, 43.5 ± ...
Plow Ela B EB Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, ND20, Cleveland, OH, 44195, USA, - - 2013
The last decade has seen a growing interest in adjuvant treatments that synergistically influence mechanisms underlying rehabilitation of paretic upper limb in stroke. One such approach is invasive neurostimulation of spared cortices at the periphery of a lesion. Studies in animals have shown that during training of paretic limb, adjuvant ...
Jolly Sanjit S SS McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada. Electronic address: - - 2014
A major limitation of primary percutaneous coronary intervention (PPCI) for the treatment of ST-elevation myocardial infarction (STEMI) is impaired microvascular perfusion due to embolization and obstruction of microcirculation with thrombus. Manual thrombectomy has the potential to reduce distal embolization and improve microvascular perfusion. Clinical trials have shown mixed results regarding ...
Malliaras Konstantinos K Cedars-Sinai Heart Institute, Los Angeles, California, - - 2014
Cell therapy for heart disease began clinically more than a decade ago. Since then, numerous trials have been performed, but the studies have been underpowered, focusing primarily on low-risk patients with a recent myocardial infarction. Many data have accumulated on surrogate endpoints such as ejection fraction, but few clinical conclusions ...
Doltra A - - 2013
The definition of response to cardiac resynchronization therapy (CRT) remains controversial, with variable rates of response depending on the criteria used. Our aim was to analyze the impact of CRT on diastolic function in different degrees of response, particularly in patients with positive clinical but no echocardiographic response. In 250 ...
Yang Yunjun Y Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, - - 2013
Supratentorial cerebral infarction can cause functional inhibition of remote regions such as the cerebellum, which may be relevant to diaschisis. This phenomenon is often analyzed using positron emission tomography and single photon emission CT. However, these methods are expensive and radioactive. Thus, the present study quantified the changes of infarction ...
Missov Emil - - 2013
Thrombotic complications are inherent to current generation nonpulsatile left ventricular assist devices. The clinical expression of device thrombosis ranges from catastrophic failure to protracted and indolent. We report the case of a 79-year-old patient who received a left ventricular assist device as destination therapy and presented only with vague clinical ...
Nakatani Shimpei - - 2013
Intravascular ultrasound (IVUS) has been clinically available for almost 25 years now and showed us valuable information regarding the coronary vessel lumen, its dimensions, the plaque burden and plaque characteristics that we were not able to assess by angiography alone. Using these abilities, IVUS has helped us to start, understand ...
Grundeken Maik J - - 2013
Coronary bifurcation lesions account for approximately 15% of all percutaneous coronary interventions (PCI) performed. Although clinical outcomes after PCI have been improved considerably, PCI of bifurcation lesions remains to be associated with adverse clinical events, when compared with non-bifurcation PCI. Therefore, several dedicated bifurcation devices have been developed to improve ...
Smulders Martijn W - - 2013
Although high-sensitivity cardiac troponin (hs-cTn) substantially improves the early detection of myocardial injury, it lacks specificity for acute myocardial infarction (MI). In suspected non-ST-elevation MI, invasive coronary angiography (ICA) remains necessary to distinguish between acute MI and noncoronary myocardial disease (eg, myocarditis), unnecessarily subjecting the latter to ICA and associated ...
Moussa Issam D ID Mayo Clinic, Jacksonville, Florida. Electronic address: - - 2013
Numerous definitions have been proposed for the diagnosis of myocardial infarction (MI) after coronary revascularization. The universal definition for MI designates post procedural biomarker thresholds for defining percutaneous coronary intervention (PCI)-related MI (type 4a) and coronary artery bypass grafting (CABG)-related MI (type 5), which are of uncertain prognostic importance. In ...
Moon James C - - 2013
Rapid innovations in cardiovascular magnetic resonance (CMR) now permit the routine acquisition of quantitative measures of myocardial and blood T1 which are key tissue characteristics. These capabilities introduce a new frontier in cardiology, enabling the practitioner/investigator to quantify biologically important myocardial properties that otherwise can be difficult to ascertain clinically. ...
Gutiérrez-Chico J L - - 2013
Percutaneous coronary interventions (PCI) have gained widespread acceptation among cardiologists and among the general population for a variety of clinical indications, comprising from stable angina to ST-elevation acute myocardial infarction, due to the undisputed clinical benefit they provide and to their large availability and accessibility. Nonetheless PCI in the left ...
Vervloet M G - - 2013
Secondary hyperparathyroidism is an almost inevitable complication of advanced kidney failure. The introduction of the calcimimetic cinacalcet for the treatment of secondary hyperparathyroidism in patients on dialysis was based on its ability to reduce elevated levels of parathyroid hormone (PTH). Subsequent clinical studies confirmed the beneficial effects of cinacalcet on ...
Phillips Lawrence M - - 2013
There is a preponderance of evidence that, in the setting of an acute coronary syndrome, an invasive approach using coronary revascularization has a morbidity and mortality benefit. However, recent stable ischemic heart disease (SIHD) randomized clinical trials testing whether the addition of coronary revascularization to guideline-directed medical therapy (GDMT) reduces ...
Yadav Mayank M Columbia University Medical Center and the Cardiovascular Research Foundation, New York, New - - 2013
The introduction of the SYNTAX (Synergy Between PCI With Taxus and Cardiac Surgery) score has prompted a renewed interest for angiographic risk stratification in patients undergoing percutaneous coronary intervention. Syntax score is based on qualitative and quantitative characterization of coronary artery disease by including 11 angiographic variables that take into ...
Thompson Peter L - - 2013
Rupture or erosion of an unstable atherosclerotic plaque is the typical pathology and usual cause of acute coronary syndromes. Despite detailed understanding of the processes of lipid accumulation, thinning of the fibrous cap, and inflammation leading to plaque instability, there are no strategies in clinical use that uniquely target the ...
Szady Anita D AD Division of Cardiovascular Medicine, University of Florida College of Medicine, 1600 S.W. Archer Rd, Gainesville, FL, USA. - - 2013
The purpose of stem cell therapy for myocardial infarction is to improve clinical outcomes, and detailed information on clinical outcomes is critical to appropriate planning of phase III trials. We have examined data from select phase II trials using autologous bone-marrow-derived stem cells in patients with acute myocardial infarction. We ...
Moussa Issam D - - 2013
Numerous definitions have been proposed for the diagnosis of myocardial infarction (MI) after coronary revascularization. The Universal Definition for MI designates post procedural biomarker thresholds for defining percutaneous coronary intervention (PCI)-related MI (type 4a) and coronary artery bypass grafting (CABG)-related MI (type 5) which are of uncertain prognostic importance. In ...
Arsenault Marie - - 2013
-Aortic valve regurgitation (AR) is a volume overload disease causing severe eccentric left ventricular hypertrophy and eventually heart failure. There is currently no approved drug to treat patients with AR. Many vasodilators including angiotensin converting enzyme inhibitors have been evaluated in clinical trials but while some results were promising, others ...
Osnabrugge Ruben Lj - - 2013
The majority (70%) of coronary revascularizations concern patients with multivessel disease (MVD). Treatment options include medical therapy, percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). CABG surgery has been shown to improve survival compared with medical therapy. PCI relieves angina compared with medical therapy and is equivalent to ...
Zannad Faiez - - 2013
Endpoint selection is a critically important step in clinical trial design. It poses major challenges for investigators, regulators, and study sponsors, and it also has important clinical and practical implications for physicians and patients. Clinical outcomes of interest in heart failure trials include all-cause mortality, cause-specific mortality, relevant non-fatal morbidity ...
Hofmann Ulrich U Department of Internal Medicine I, University Hospital Würzburg, Oberdürrbacher Straße 6, 97080, Würzburg, Germany. - - 2013
The prevalence of chronic heart failure is still increasing making it a major health issue in the 21st century. Tremendous evidence has emerged over the past decades that heart failure is associated with a wide array of mechanisms subsumed under the term "inflammation". Based on the great success of immuno-suppressive ...
Bennett Mosi K - - 2013
BACKGROUND: -Endomyocardial biopsy (EMB) is often considered when the etiology of heart failure cannot be determined by non-invasive testing. Uncertainty remains about the diagnostic and clinical utility of EMB in various clinical scenarios. METHODS AND RESULTS: -We examined the characteristics of a cohort of patients with unexplained heart failure who ...
Lee Sangjin - - 2013
The development of ventricular assist devices (VADs) over the past 5 decades as therapy for advanced heart failure (HF) has been extraordinary. Since the original VAD design by Michael DeBakey in the early 1960s, numerous devices for mechanical circulatory support have been engineered, assessed in preclinical studies, applied to human ...
Prinz Christian - - 2013
BACKGROUND: Until now, there is no consensus regarding the definition of a clinical response to cardiac resynchronization therapy (CRT) in patients with chronic heart failure (CHF) and systolic left ventricular (LV) dysfunction. The aim of this study was to evaluate if echocardiography is predictive for an objective improvement in exercise ...
Tojo Hideaki - - 2013
Human chymase, an angiotensin II-forming chymotrypsin-like serine proteinase, posses various biological actions mediating through local angiotensin II formation in the tissue level of many cardiovascular organs. Our previous experimental data have shown that chymase inhibitor increased a survival rate of the hamster post-myocardial infarction model with concomitant improvements of the ...
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