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Lewis Joshua R JR University of Western Australia School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, Perth, Australia; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, - - 2014
In their letter responding to our recent meta-analysis (1), Drs' Bolland, Grey and Reid express a number of opinions about the methodology and the conclusions drawn from the current meta-analysis. While we appreciate the authors' enthusiasm on the subject, we disagree with their interpretation of the current published literature. To ...
Ortiz-Vilchis Pilar P Escuela Superior de Medicina del Instituto Politecnico Nacional, Seccion de Posgrado, Mexico City, - - 2014
(-)-Epicatechin (EPI) is cardioprotective in the setting of ischemia/reperfusion (IR) injury and doxycycline (DOX) is known to preserve cardiac structure/function after myocardial infarction (MI). The main objective of this study was to examine the effects of EPI and DOX co-administration on MI size after IR injury and to determine if ...
Alassar Aiman A Department of Cardiothoracic Surgery, Derriford Hospital, Plymouth, UK - - 2014
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was 'What is the value of topical cooling as an adjunct to myocardial protection?' Using the reported search, 9 papers represented the best evidence to answer the clinical question. The authors, journal, date ...
Hoffmeister C C Diabetes Center, Heart and Diabetes Center North Rhine-Westphalia, University Hospital of the Ruhr-University Bochum, Bad Oeynhausen, Germany, - - 2014
The effect of beta blockers on myocardial blood flow (MBF) under vasodilators has been studied in several SPECT and PET myocardial perfusion imaging (MPI) studies with divergent results. The present study evaluated the effect of a beta blocker withdrawal on quantitative adenosine MBF and on MPI results. Twenty patients with ...
Carpenter John-Paul - - 2014
The assessment of myocardial iron using T2* cardiovascular magnetic resonance (CMR) has been validated and calibrated, and is in clinical use. However, there is very limited data assessing the relaxation parameters T1 and T2 for measurement of human myocardial iron. Twelve hearts were examined from transfusion-dependent patients: 11 with end-stage ...
Leoncini Mario M Cardiology Division of Prato Hospital, Prato, - - 2014
There is a strong correlation between adverse clinical events and peak values of myocardial necrosis markers in non-ST-elevation acute coronary syndrome patients. In this clinical setting, high-dose statin treatment exerts acute beneficial effects against renal and myocardial damage. The aim of this report was to evaluate if, on admission, high-dose ...
Dunlop Joanna Leigh - - 2014
The Sodium Lowering in Dialysate (SoLID) trial is an ongoing a multi-center, prospective, randomised, single-blind (assessor), controlled, parallel assignment clinical trial, enrolling 96 home and self-care hemodialysis (HD) patients from 7 centers in New Zealand. The trial will evaluate the hypothesis that lower dialysate [Na+] during HD results in lower ...
Sundh Frida F Department of Clinical Physiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, - - 2014
The number of patients with severe aortic stenosis getting treated with transcatheter aortic valve replacement (TAVR) is rapidly growing and the outcome after the procedure is very good. However, the incidence of new persistent left bundle branch block (LBBB) following the TAVR procedure is high and the impact of this ...
Parsaee Mozhgan M Echocardiography Research Center, Shaheed Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. - - 2014
This study attempted to identify the role of combined conventional and novel echocardiographic techniques in evaluation of left atrial (LA) function to predict the postoperative atrial fibrillation (POAF). In this cross-sectional study, subjects with sinus rhythm who were candidates for CABG were enrolled. Preoperative LA function was evaluated by conventional ...
Chaudhry Umar A R UA Department of Surgery and Cancer, Imperial College London, London, United - - 2014
Early outcomes for off-pump coronary artery bypass grafting (OPCAB) have been extensively compared with on-pump coronary revascularization (ONCAB); however, the long-term effects of OPCAB continue to be debated. This study aims to compare the mid-term (>1year; ≤5 years) and long-term (>5 years) survival and major adverse cardiovascular and cerebrovascular events ...
Yilmaz H H Department of Internal Medicine, Section of Nephrology, Turgut Ozal University, School of Medicine, Alparslan Türkes Cad. No: 57, 06510, Emek/Ankara, Turkey, - - 2014
Galectin-3 (Gal-3) is used to determine the prognosis of heart failure. Some studies revealed that Gal-3 promoted cardiac hypertrophy but there is no study in which the relationship between Gal-3 and left ventricular hypertrophy (LVH) geometry in patients without diastolic and systolic function impairment has been explored. The aim of ...
Laake Kristian - - 2014
Both epidemiological and randomized clinical studies suggest that supplementation with very-long-chain marine polyunsaturated n-3 fatty acids (n-3 PUFA) have cardioprotective effects, however these results are not without controversy. Study population, sample-size, type of supplementation and type of endpoint have all varied widely accross different studies.Therefore, the aims of the present ...
Aronis K N KN 1] Department of Nutrition Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School [2] Department of Radiology Division of Endocrinology Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School [3] Department of Medicine, Boston Medical Center, Boston University School of - - 2014
Introduction:Irisin is a newly discovered myokine, associated with «browning» of the white adipose tissue, obesity, insulin resistance and metabolic syndrome. The purpose of this study is to evaluate circulating irisin as predictor of acute coronary syndromes (ACS) and major adverse cardiovascular events (MACE).Methods:Sub-study 1: a case control study, nested within ...
Okishige Kaoru K Heart Center, Yokohama-City Bay Red Cross Hospital, Yokohama, Japan, - - 2014
Macro-reentrant ventricular tachycardias (VT) utilizing the bundle branches and Purkinje fibers have been reported as verapamil sensitive VT (idiopathic left VT), bundle branch reentrant VT (BBRT) and inter-fascicular reentrant tachycardia (inter-fascicular VT). However, diagnostic confusion exists with these VTs due to the difficulty in differentiating between them with conventional electrophysiological ...
Fuernau Georg G Department of Internal Medicine/Cardiology, University of Leipzig-Heart Center, Leipzig, Germany. Electronic address: - - 2014
Nonrandomized studies suggested lower mortality rates with statin pretreatment in patients with acute ST elevation myocardial infarction (STEMI). However, clinical data are still inconclusive and the mechanisms of these presumed beneficial effects require further exploration. Cardiac magnetic resonance (CMR) imaging offers the possibility of studying a variety of markers of ...
Cohen Marc M Newark Beth Israel Medical Center, Barnabas Health, Mount Sinai School of Medicine, New York, NY, - - 2014
Acute coronary syndrome (ACS) is a medical emergency often associated with an occlusive coronary event with consequent myocardial underperfusion. Patients require immediate antiplatelet therapy and long-term antithrombotic prophylaxis to reduce the risk of recurrence. Acetylsalicylic acid alone or in combination with a platelet P2Y12 inhibitor (dual antiplatelet therapy) has become ...
Carbonnelle Eric E UMR_S 1039, Radiopharmaceutiques Biocliniques, INSERM, Grenoble, - - 2014
The great clinical potential of myocardial β-AR imaging has been shown by recent studies evaluating the β-AR-specific, non-selective agent [(11)C]-CGP12177 in the setting of idiopathic-dilated cardiomyopathy, and myocardial infarction. However, the short half-life of (11)C hampers the potential of [(11)C]-CGP12177 for routine clinical use. AMI9 is an analog of the ...
Koopmann Matthias M Division of Electrophysiology, Department of Cardiovascular Medicine, University Hospital of Münster, Münster, - - 2014
Both post-contrast myocardial T1 and extracellular volume (ECV) measurements have been associated with diffuse interstitial fibrosis. The cardiovascular magnetic resonance (CMR) field is migrating towards ECV, because it is largely insensitive to confounders that affect post-contrast myocardial T1 . Despite the theoretical advantages of myocardial ECV over post-contrast myocardial T1 ...
Wu Fu-Zong - - 2014
There is growing evidence about the importance of epicardial adiposity on cardiometabolic risk. However, the relation of location-specific epicardial adipose tissue (EAT) thickness to coronary atherosclerotic burden is still unclear. This meta-analysis was used to study the relations between location-specific EAT thickness and obstructive coronary artery disease (CAD). A systemic ...
Leary Peter J PJ 1 Department of - - 2014
Right heart failure is a cause of morbidity and mortality in common and rare heart and lung diseases. Exposure to traffic-related air pollution is linked to left ventricular hypertrophy, heart failure, and death. Relationships between traffic-related air pollution and right ventricular (RV) structure and function have not been studied. To ...
Iwasaki Kohichiro K Kohichiro Iwasaki, Department of Cardiology, Okayama Kyokuto Hospital, Okayama 703-8265, - - 2014
Previous studies demonstrated that coronary revascularization, especially percutaneous coronary intervention (PCI), does not significantly decrease the incidence of cardiac death or myocardial infarction in patients with stable coronary artery disease. Many studies using myocardial perfusion imaging (MPI) showed that, for patients with moderate to severe ischemia, revascularization is the preferred ...
Manivannan Jeganathan J Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, 608 002, Tamilnadu, - - 2014
Cardiovascular dysfunction and vascular calcification is the leading cause of death in chronic renal failure (CRF) patients. This study was designed to evaluate the effect of diosgenin on coronary flow resistance and to address the question whether the previously proven antivascular calcification potential of diosgenin is associated or not with ...
Miller Todd D TD Division of Cardiovascular Diseases and the Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA, - - 2014
One of the major strengths of nuclear myocardial perfusion imaging (MPI) is the robust prognostic databases from observational studies demonstrating significantly different outcomes in patients with low-risk vs high-risk scans. The severity of the MPI defect can be semi-quantitated using the summed stress score (SSS) and summed difference score (SDS). ...
Kapelios Chris J CJ The 3rd Department of Cardiology, University of Athens School of Medicine, Athens, - - 2014
The intra-aortic balloon pump (IABP) has been used for more than 40 years. Although recommended in a wide variety of clinical settings, most of these indications are not evidence-based. This review focuses on studies challenging these traditional indications and evaluates potentially new applications of intra-aortic counterpulsation. Recent studies have failed ...
Hong Lifeng L Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China; Divison of Cardiology, Fifth Hospital of Wuhan & Affiliated Guangci Hospital of Wuhan University, Wuhan, Hubei 430050, - - 2014
Small case series have suggested an association of coronary myocardial bridge (MB) with myocardial infarction (MI). However, the relationship between MB and major adverse cardiac events (MACE) remains largely unknown. The aim of this study was to assess the relationship between MB and MACE involving MI. We performed a systematic ...
Klinkenberg Lieke J J LJ Department of Clinical Chemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, the - - 2014
To test the unverified assumption that chronically elevated cardiac troponin T (cTnT) levels fluctuate randomly around a homeostatic setpoint. The introduction of high-sensitivity cTn assays has improved sensitivity for acute myocardial infarction (AMI). However, many patients with a single positive cTn test have in fact no AMI. Therefore, the diagnosis ...
Jang Jae-Sik JS Department of Cardiology, Busan Paik Hospital, University of Inje College of Medicine, Busan, South Korea. Electronic address: - - 2014
The aim of this study was to systematically review and perform a meta-analysis of randomized trials and observational studies of intravascular ultrasound (IVUS)-guided versus angiography-guided implantation of drug-eluting stents (DES). Although studies in the bare-metal stents era suggested that there were clinical benefits to IVUS guidance, it is still controversial ...
Watanabe Tetsu T Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan. Electronic address: - - 2014
Many clinical trials have shown that 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can significantly reduce coronary artery disease in both primary and secondary prevention. A recent study showed that aggressive lipid-lowering therapy with strong statins could achieve coronary artery plaque regression, as evaluated with gray-scale intravascular ultrasound (IVUS). However, it ...
Johansson Lena L Department of Molecular and Clinical Medicine, Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, - - 2014
The aim of this myocardial perfusion imaging (MPI) study was to compare the diagnostic performance of two computer-aided diagnosis (CAD) systems, EXINI Heart(TM) (EXINI), and PERFEX(TM) (PERFEX) Emory Cardiac Toolbox (ECT), and the summed stress score (SSS) values from both software packages. We studied 1,052 consecutive patients who underwent 2-day ...
Mananga Eugene S ES Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Radiology, Harvard Medical School, Boston, Massachusetts, United States of - - 2014
It is expected that both noise and activity distribution can have impact on the detectability of a myocardial defect in a cardiac PET study. In this work, we performed phantom studies to investigate the detectability of a defect in the myocardium for different noise levels and activity distributions. We evaluated ...
Cheng Chao C Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, - - 2014
Recent studies have demonstrated that acute myocardial infarction induces a distinctive miRNA signature, suggesting that miRNAs may serve as diagnostic markers. Although many studies have investigated the use of miRNAs in the detection of cardiac injury, some had small sample sizes (<100 patients) or reported different results for the same ...
Iyngkaran Pupalan P Department of Cardiology, Royal Darwin Hospital, Tiwi, Northern Territory, - - 2014
Congestive heart failure is a significant cause of morbidity and mortality in Australia. Accurate data for the Northern Territory and Indigenous Australians are not presently available. The economic burden of this chronic cardiovascular disease is felt by all funding bodies and it still remains unclear what impact current measures have ...
B Rawson Nigel S - - 2014
BackgroundFollowing the publication of a meta-analysis reporting a risk of acute myocardial infarction (AMI) with rosiglitazone that led to severe restrictions being placed on its use, several observational studies of the association were reported. The lifting of restrictions in the United States in 2013 makes a review of these studies ...
Wang Le L Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, The Key Laboratory of Remodeling-Related Cardiovascular Disease, Ministry of Education, Beijing 100029, - - 2014
Evidence suggests that high-dose statin pretreatment may reduce the risk of periprocedural myocardial infarction (PMI) and major adverse cardiac events (MACE) for certain patients; however, previous analyses have not considered patients with a history of statin maintenance treatment. In this meta-analysis of randomized controlled trials (RCTs), we reevaluated the efficacy ...
Aminian Farimah F Razavi Hospital, Mashad, - - 2013
The aim of this study was to determine the impact of manifest accessory pathway on left ventricle (LV) twist physiology in Wolff-Parkinson-White (WPW) patients. Although this issue was addressed in 1 study based on speckle tracking method, there was no comparative study with a different technique. We planned to use ...
Pravdic Danijel - - 2013
Over the years, an electrocardiogram had become the basic tool to study the heart physiology and pathophysiology. Many authors gave a substantial contribution in understanding the electrophysiological basis for numerous electrocardiographic changes. Some of them were named after authors themselves, or others used the names of scientists who first discovered ...
- - 2013
A short-cut review was carried out to establish whether intra-aortic balloon pumps (IABP) improve mortality in cardiogenic shock after acute myocardial infarction (AMI). Two studies and one systematic review were directly relevant to the question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results ...
- - 2013
A short-cut review was carried out to establish whether levosimendan improves outcome in cases of cardiogenic shock. Five studies were directly relevant to the question. One very general systematic review and meta-analysis is also included. The author, date and country of publication, patient group studied, study type, relevant outcomes, results ...
Rowland Andrew - - 2013
Introduction: The P450 enzymes (P450s) mediate the biotransformation of several drugs, steroid hormones, eicosanoids, cholesterol, vitamins, fatty acids and bile acids, many of which affect cardiovascular homeostasis. Experimental studies have demonstrated that several P450s modulate important steps in the pathogenesis of ischemic heart disease (IHD). Areas covered: This article discusses ...
Cortés Olga L - - 2013
This study was aimed to identify the mobilization patterns of acute myocardial infarction (AMI) patients during their first three days in the coronary care unit (CCU) by performing a prospective observational pilot study design. The study included 31 diagnosed AMI patients admitted to three CCUs. Mobilization patterns classified as bed ...
Dharmarajan Kumar K The China PEACE Collaborative Group: State Key Laboratory of Cardiovascular Disease, China Oxford Centre for International Health Research, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China; and The Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT; Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, - - 2013
Cardiovascular diseases are rising as a cause of death and disability in China. To improve outcomes for patients with these conditions, the Chinese government, academic researchers, clinicians, and >200 hospitals have created China Patient-Centered Evaluative Assessment of Cardiac Events (China PEACE), a national network for research and performance improvement. The ...
Khawaja Farhan J - - 2013
Appropriate use criteria (AUC) for single-photon emission computed tomography myocardial perfusion images (SPECT-MPI) were developed to address the growth of cardiac imaging studies. However, these criteria have not been vigorously validated. We sought to determine the rate of abnormal stress SPECT-MPI studies and subsequent revascularization procedures as categorized by AUC. ...
Acharji Subasit - - 2013
The recently published Intra-aortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial concluded that intra-aortic counterpulsation (IACP) does not reduce 30-day mortality in patients with cardiogenic shock (CS) complicating acute myocardial infarction (AMI) for whom early revascularization strategy was planned. The study resulted in downgrading IACP in post-AMI CS ...
Bennett Johan R - - 2013
Commercially available implantable defibrillators utilize a high-tilt waveform. Studies in atrial fibrillation and transthoracic defibrillation of ventricular fibrillation (VF) have shown improved defibrillation efficacy using low-tilt (LT) waveforms. We investigated the feasibility, efficacy, and safety of a LT waveform in the transvenous defibrillation of VF and hypothesized that it would ...
Khoshhal Saad Q - - 2013
To assess the feasibility and efficacy of the real-time transthoracic 3-dimensional echocardiography (RTT-3DE) technique in providing more detailed information compared to 2-dimensional echocardiography (2DE) in patients with structural heart disease, and to explore its application in routine clinical use. This cross sectional study was carried out at the Prince Sultan ...
Perrier Stéphanie - - 2013
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was as follows: is coronary artery bypass graft (CABG) surgery superior to percutaneous coronary intervention (PCI) in terms of in-hospital mortality and morbidity and long-term outcomes in patients with acute myocardial infarction (MI)? ...
Junehag Lena - - 2013
The aim of this study was to describe individuals' perceptions of the psychosocial consequences of an acute myocardial infarction (AMI) and of their access to support one year after the event. The study included 20 participants (14 men and six women) who lived in rural areas and had experienced their ...
Nawathe Amar - - 2013
Left atrial (LA) abnormality, an easily quantifiable parameter of left ventricular (LV) diastolic dysfunction, has been associated with cardiovascular risk similar to that of LV hypertrophy. The correlation between LV hypertrophy and LA abnormality among patients undergoing myocardial perfusion (MP) study has not been described. We prospectively studied 78 consecutive ...
Longman Kristel - - 2013
Contemporary studies have demonstrated that revascularization therapy targeted at coronary anatomy alone has not been able to consistently yield significant prognostic clinical outcomes. The practice of specific ischemia-targeted intervention for coronary disease in certain study populations has, however, produced important and reproducible clinical outcomes in terms of both symptoms and ...
Nadir M Adnan - - 2013
Plasma BNP and high-sensitivity cardiac troponin-T (hs-TnT) are elevated by both ischaemia and LV systolic dysfunction (LVSD). As a result, it is unknown whether BNP and/or hs-TnT could be useful biomarkers to identify ischaemia in the presence of LVSD. Three separate patient populations were studied. Study A (n = 500) ...
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