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Tuladhar A S - - 2013
A prospective study was carried out during 2010 - 2011 in the Department of Radiology & Imaging of Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu and Om Hospital and Research Centre, Chabahil, Kathmandu in which a total of 45 patients with clinically and CT scan diagnosed ischaemic cerebrovascular accident ...
Ferguson Jane F JF Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, - - 2013
This study sought to identify loci for coronary artery calcification (CAC) in patients with chronic kidney disease (CKD). CKD is associated with increased CAC and subsequent coronary heart disease (CHD), but the mechanisms remain poorly defined. Genetic studies of CAC in CKD may provide a useful strategy for identifying novel ...
Huang Stephen J - - 2013
INTRODUCTION: Reversible myocardial depression occurs early in severe sepsis and septic shock. The question of whether or not early ventricular depression or dilatation is associated with lower mortality in these patients remains controversial. Most studies on this topic were small in size and hence lacked statistical power to answer the ...
Bittl John A JA Ocala Heart Institute, Munroe Regional Medical Center, 1221 SE 5th St, Ocala, FL 34471, USA. - - 2013
Several randomized clinical trials support the use of coronary artery bypass grafting (CABG) for patients with unprotected left main coronary artery disease. Studies suggesting the equivalence of percutaneous coronary intervention (PCI) with CABG for this indication indirectly support the 2011 American College of Cardiology Foundation/American Heart Association Class IIa recommendation ...
Ammirati Enrico - - 2013
Four monocentric studies reported that circadian rhythms can affect left ventricular infarct size after ST-segment-elevation acute myocardial infarction (STEMI). To further validate the circadian dependence of infarct size after STEMI in a multicentric and multiethnic population. We analyzed a prospective cohort of subjects with first STEMI from the First Acute ...
Askew J Wells JW Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA. - - 2013
To assess stress single-photon emission computed tomography (SPECT) and stress echocardiography use after coronary artery bypass grafting (CABG) and their effect on referral for coronary angiography and revascularization. The referral, timing, and results of stress imaging after CABG; referral for coronary angiography and revascularization; and all-cause mortality were assessed in ...
Santhanakrishnan Rajalakshmi - - 2013
Heart failure (HF) with preserved ejection fraction (EF) accounts for a substantial proportion of cases of HF, and to date no treatments have clearly improved outcome. There are also little data comparing HF cohorts of differing ethnicity within the Asia-Pacific region. The Singapore Heart Failure Outcomes and Phenotypes (SHOP) study ...
Cuspidi Cesare - - 2013
AIM:: Experimental and clinical evidence supports the view that right ventricular hypertrophy (RVH) may parallel left ventricular hypertrophy in systemic hypertension; a comprehensive analysis of this issue, however, is lacking. Thus, we analyzed the literature in order to provide an updated information on the right ventricular structural changes associated to ...
Cuspidi Cesare - - 2013
BACKGROUNDLeft atrial enlargement (LAE) is a marker of hypertensive heart disease associated with increased cardiovascular risk. We reviewed recent literature about the prevalence of LAE, as assessed by echocardiography, to update our information about the clinical relevance of this cardiac phenotype in human hypertension.METHODSWe performed a search of MEDLINE using ...
Miriyala Sumitra - - 2013
Neutrophil infiltration plays a major role in the pathogenesis of myocardial injury. Oxidative injury is suggested to be a central mechanism of the cellular damage after acute myocardial infarction. This study is pertained to the prognostic role of a tetrapeptide derivative PEP1261 (BOC-Lys(BOC)-Arg-Asp-Ser(tBu)-OtBU), a peptide sequence (39-42) of lactoferrin, studied ...
Vlachaki Chrisanthy - - 2013
Coronary Heart Disease (CHD) is associated with emotions, especially negative ones, namely anxiety and depression. Emotional Intelligence (EI) is a psychological model that consists of a variety of emotional skills. The aim of the present study was to examine the relation between different dimensions of Emotional Intelligence and coronary heart ...
Reilly Dermot D Department of Molecular Profiling and Research informatics, Merck Research Laboratories, Merck & Co., Inc., Whitehouse Station, New Jersey, United States of - - 2013
With the advance of genome-wide association studies and newly identified SNP (single-nucleotide polymorphism) associations with complex disease, important discoveries have emerged focusing not only on individual genes but on disease-associated pathways and gene sets. The authors used prospective myocardial infarction case-control studies nested in the Nurses' Health and Health Professionals ...
Williams Paul T PT Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, California, United States of - - 2013
Test whether angiographically-documented changes in percent stenosis and clinical endpoints (coronary-related deaths, myocardial infarctions, stroke, revascularization for worsening ischemia) in the HDL-Atherosclerosis Treatment Study (HATS) were attributable to specific LDL-subclasses. Gradient gel electrophoresis of on-study LDL-subclass cholesterol concentrations were measured in 32 placebo, 33 simvastatin-niacin, 38 antioxidant, and 39 simvastatin-niacin ...
Busch Sarah Victoria Ekeløf - - 2012
Objective: To evaluate the current prophylactic strategies against CIN in patients with STEMI treated by primary percutaneous coronary intervention. Background: Contrast-induced nephropathy (CIN) is the third leading course of acute renal failure and a recognized complication to cardiac catheterization. CIN is associated with increased risk of cardiac adverse events and ...
Calise Justine J Center for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, New York 11030, - - 2013
The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in pathophysiology. Many of these studies have focused in on the cardiovascular system and have determined that the UPS becomes dysfunctional in several pathologies such ...
Verger Antoine - - 2012
PURPOSE: The results of stress myocardial perfusion SPECT could be enhanced by new cadmium-zinc-telluride (CZT) cameras, although differences compared to the results with conventional Anger cameras remain poorly known for most study protocols. This study was aimed at comparing the results of CZT and Anger SPECT according to various study ...
Li Jie-Yuan - - 2012
Recent studies in normal subjects suggested the callosal motor fibers pass through the posterior body of the corpus callosum (CC) but this has not been tested in patients with callosal infarction. The objective of the study is to define the pathways involved in transcallosal inhibition by examining patients with infarctions ...
Kimmoun Antoine - - 2012
ABSTRACT: Acidosis is one of the major consequences of hemodynamic instability in shock state patients directly associated with multiple organ failure evolution and death. Most studies on the hemodynamic consequences of acidosis have been experimental, nonhuman studies with severe acidosis, and thus far from the most common clinical situations. Schotola ...
Jang Sung Ho - - 2012
Previous studies on the mechanisms of motor recovery in patients with middle cerebral artery (MCA) infarct except for the studies on cortical peri-infarct reorganization after primary motor cortex infarct were reviewed. Eight studies were classified and reviewed by the following four motor recovery mechanisms: contribution of premotor cortex, subcortical peri-infarct ...
Perazzolo Marra Martina - - 2012
BACKGROUND: Tako-Tsubo cardiomyopathy (TTC) presents with chest pain, ST-segment elevation followed by T-waves inversion and QT interval prolongation (Wellens' ECG pattern) and left ventricular (LV) dysfunction, which may mimic an acute coronary syndrome. OBJECTIVE: This study assessed the pathophysiologic basis of the Wellens' ECG pattern in TTC by characterization of ...
Kunadian Vijayalakshmi - - 2012
BACKGROUND: Coronary artery disease (CAD) is the most common cause for left ventricular dysfunction. Coronary artery bypass surgery (CABG) has not reduced mortality among patients with CAD and left ventricular systolic dysfunction receiving guideline-indicated pharmacological therapy. However, the benefit of percutaneous coronary intervention (PCI) among patients with left ventricular systolic ...
Barrère-Lemaire Stéphanie - - 2012
Ischemic postconditioning applied at the onset of reperfusion reduces myocardial infarction in both animals and humans. Our recent study on the mouse myocardium showed for the first time that delayed postconditioning (applied up to 30 min after the onset of reperfusion) can decrease infarct size. The existence of a longer ...
Johnston Kiersten - - 2012
To review the primary literature evaluating the effect preoperative use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) has on the risk of postoperative atrial fibrillation following coronary artery bypass grafting (CABG). PubMed was searched from January 1, 2000, to May 17, 2012, using the MeSH terms coronary ...
Adams Jonathon C - - 2012
Premature ventricular complexes (PVCs) are a common occurrence in clinical practice. The clinical presentation may range from asymptomatic to left ventricular (LV) dysfunction with congestive heart failure. The decision to suppress PVCs is largely based on the presence of symptoms, interference with other therapy (e.g., cardiac resynchronization therapy), or suspicion ...
Jared Bunch T - - 2012
Ventricular tachycardia (VT) is a common but serious arrhythmia that significantly adds to the morbidity and mortality of patients with structural heart disease. Percutaneous catheter ablation has evolved to be standard therapy to prevent recurrent implantable cardioverter defibrillator shocks from VT in patients on antiarrhythmia medications. Procedural outcomes in patients ...
d'Avila Andre - - 2012
Since the introduction of percutaneous epicardial access for the purpose of mapping and ablation of cardiac arrhythmias, this technique has become an important adjunct and at times the preferred approach to treat certain cardiac arrhythmias. In addition, this approach is currently also being considered for a number of other cardiovascular ...
Della Bella Paolo - - 2012
Substrate-based approaches for ablation of unmappable ventricular tachycardia (VT) are strictly dependent on high-density mapping of the scar. Ultra-high-density mapping with multielectrode catheters facilitates an accurate and faster definition of sites critical for re-entry, due to the possibility of simultaneous recordings of local potential from different pairs of electrodes. Multipolar ...
Chapel Emily H EH Michigan State University, College of Veterinary Medicine, East Lansing, MI 48823, - - 2012
Compare the efficacy of two cardiac pacing catheters for transesophageal atrial pacing (TAP). Ten healthy dogs. Transesophageal atrial pacing was attempted in left lateral recumbency under general anesthesia. In series, a curved electrophysiologic (EP) catheter and a straight transesophageal pacing (TP) catheter were passed transorally into the distal esophagus, caudal ...
Schneider Heike E - - 2012
Characterization of the Critical Isthmus in VT in TOF. Introduction: The complexity of postoperative ventricular reentrant tachycardias may limit success of catheter ablation. The objective of this analysis was to compare the usefulness of dynamic substrate mapping (DSM) versus color-coded isopotential mapping of the noncontact mapping system for the identification ...
Delgadillo Hilda - - 2012
The aim of this study was to test for association between MHC2TA gene polymorphisms and risk for restenosis after coronary stent placement in a group of Mexican patients. The MHC2TA-168A>G (rs3087456), 1614C>G (rs4774), and 2536G>A (rs2229320) single nucleotide polymorphisms were genotyped using 5' exonuclease TaqMan genotyping assays in a group ...
Roten Laurent - - 2012
Ablation of ventricular tachycardia (VT) by conventional radiofrequency ablation can be impossible if the ventricular wall at the targeted ablation site is very thick, as for example the ventricular septum. We present a case of a patient with incessant, non-sustained slow VT originating from the septal part of the lower ...
Caldwell Jane - - 2012
Catheter ablation is increasingly being utilized for the treatment of ventricular tachycardia (VT) but is not without complications. In this image article, we present the unique finding of a LV to CS fistula as discovered incidentally on transthoracic echo post VT ablation.
Cheng Chien-Ming - - 2012
AIMS: This study investigated the relationship between the ostia of the coronary sinus (CS) and the tricuspid annulus (TA) for CS cannulation using a right ventricular (RV) lead, which could map out the TA by forming a curve when placed at the apex or low septum.METHODS AND RESULTS: Seventy patients ...
Niemann James T JT David Geffen School of Medicine at UCLA, Los Angeles, CA, United States. - - 2013
Inflammatory cytokines have been implicated in the pathophysiology of post cardiac arrest syndrome, including myocardial dysfunction and hypotension, often leading to multi-organ system dysfunction and death. We hypothesized that administration of infliximab after return of spontaneous circulation (ROSC) would ameliorate hypotension and myocardial dysfunction and prolong survival. Domestic swine were ...
Liu Chenguang C Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, - - 2012
The three-dimensional cardiac electrical imaging (3DCEI) technique was previously developed to estimate the initiation site(s) of cardiac activation and activation sequence from the noninvasively measured body surface potential maps (BSPMs). The aim of this study was to develop and evaluate the capability of 3DCEI in mapping the transmural distribution of ...
Ugander Martin - - 2012
The aim of this study was to determine whether cardiac magnetic resonance (CMR) in vivo T1 mapping can measure myocardial area at risk (AAR) compared with microspheres or T2 mapping CMR. If T2-weighted CMR is abnormal in the AAR due to edema related to myocardial ischemia, then T1-weighted CMR should ...
Chillou Christian DE - - 2012
The number of scar-related ventricular tachycardia (VT) ablation procedures is increasing worldwide. This is certainly due to the ever growing number of patients implanted with an implantable cardioverter defibrillator in whom an ablation procedure may be required to better control the ventricular arrhythmia burden, but is also likely related to ...
Yamada Takumi - - 2012
Ablation strategies for almost all types of ventricular tachycardias have now been established. The optimal ablation strategy for ventricular tachycardia is determined by the site of origin and the electrophysiological mechanisms. Electrocardiograms, an understanding of the common sites of basic disease, and identification of the scar site using imaging modalities ...
Ng Jason - - 2012
This study sought to test the hypothesis that "virtual" electrophysiological studies (EPS) on an anatomic platform generated by 3-dimensional magnetic resonance imaging reconstruction of the left ventricle can reproduce the reentrant circuits of induced ventricular tachycardia (VT) in a porcine model of myocardial infarction. Delayed-enhancement magnetic resonance imaging has been ...
Herczku Csaba - - 2012
BACKGROUND: -The proximity of the outflow tracts (OTs) frequently results in an overlap in surface electrocardiographic (ECG) features of ventricular arrhythmias (VAs) originating from this anatomic region, particularly when the transition occurs in lead V3. In addition, no reliable criteria to discriminate between a right ventricular outflow tract (RVOT) and ...
Guérios Enio E - - 2012
Previous reports prove the safety and efficacy of cardiac pacing employing a guidewire in the left ventricle as unipolar pacing electrode. We describe the use of left ventricular guidewire pacing as an alternative to conventional transvenous temporary right ventricular pacing in the context of transcatheter aortic valve implantation. © 2012 ...
Tian Jing - - 2012
The integration of myocardial scar models in 3-dimensional (3D) mapping systems may provide a novel way of helping to guide ventricular tachycardia (VT) ablations. This study assessed the value of (201)Tl SPECT perfusion imaging to define ventricular myocardial scar areas and to characterize electrophysiology voltage-derived myocardial substrate categories of scar, ...
Bradley Steven M - - 2012
BackgroundIn anticipation of applying Appropriate Use Criteria for percutaneous coronary intervention (PCI) quality improvement, we determined the prevalence of appropriate, uncertain, and inappropriate PCIs stratified by indication for all PCIs performed in the state of Washington.Methods and ResultsWithin the Clinical Outcomes Assessment Program, we assigned appropriateness ratings to all PCIs ...
Fahmi F - - 2012
BACKGROUND AND PURPOSE:Although CT perfusion is a promising tool to support treatment decisions for patients with acute ischemic stroke, it still lacks a standardized method for CTP analysis. The purpose of this study was to assess the variability of the area of infarct core and penumbra as presented in summary ...
Makhija Aman A Fellow Electrophysiology, CARE Hospitals, Institute of Medical Sciences, Hyderabad, - - 2012
Radiofrequency ablation is a therapeutic option for recurrent ventricular tachycardia (VT) in both ischaemic and non-ischaemic subsets. Usually this is attempted by mapping endocardially; however, in some situations epicardial approach may be needed to access the VT circuit. We report two cases in which epicardial approach was used to successfully ...
Jaïs Pierre - - 2012
BACKGROUND: Catheter ablation of ventricular tachycardia (VT) is effective and particularly useful in patients with frequent defibrillator interventions. Various substrate modification techniques have been described for unmappable or hemodynamically intolerable VT. Non-inducibility is the most frequently used endpoint but is associated with significant limitations such that the optimal endpoint remains ...
Nitta Takashi - - 2012
An electroanatomic mapping system using an electromagnetic navigation technology constructs a 3-dimensional structure of the heart with high geometric accuracy of the data that provides a precise localization of the substrates of arrhythmias. The system was tested for the feasibility and efficacy in intraoperative mapping. The strength of the magnetic ...
Donoiu I I Department of Cardiology, Craiova University of Medicine and Pharmacy, - - 2012
Since its initial description, a number of studies have described the use of microvolt T-wave alternans (MTWA) as a predictor of the primary or secondary occurrence of ventricular arrhythmic events. These studies, however, have been limited by small sample sizes and disparate patient populations. Studies of MTWA in post-myocardial infarction ...
Wang Amy A Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University . Brooklyn, NY ( United States - - 2012
Atrial fibrillation is a common cardiac arrhythmia, and has been a significant financial burden. Class III antiarrhythmics such as dofetilide, ibutilide, and amiodarone are indicated for rhythm control. Magnesium may possess intrinsic antiarrhythmic properties, and may potentially increase the efficacy of class III antiarrhythmics when used concomitantly. The purpose of ...
Walters Tomos E - - 2012
Atrial tachycardia is a generic term for a range of tachyarrhythmias with their origin in the atria. These can be broadly divided by mechanism into macro-reentrant, focal and small circuit re-entry. "Atrial flutter" is a term which, today, should be restricted to those classical circuits around the tricuspid annulus dependent ...
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