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Keenan Katherine K Division of Paediatric Gastroenterology, Hepatology and Nutrition, University of Toronto and Physiology and Experimental Medicine, Research Institute, the Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: - - 2014
The current practice of averaging the nasal potential difference (NPD) results of right and left nostril measurements reduce inter-individual variability but may underestimate individual CFTR function. Best NPD response to Cl(-)-free and isoproterenol perfusion (=largest ΔPD0Cl/Iso) from the right and left nostril was compared to the average result in 13 ...
Varr Brandon C BC Division of Cardiology, Columbia University Medical Center, New York, NY, USA, - - 2014
Acute heart failure (AHF) remains a major cause of morbidity and mortality, with an increasing prevalence anticipated over the next few decades as the population ages, heightening already significant health and economic burdens to society. New therapies for AHF have stalled over the past decade for a multitude of reasons, ...
Hopkins Paul N PN Cardiovascular Genetics, Department of Internal Medicine, University of Utah, 420 Chipeta Way, Room 1160, Salt Lake City, UT, 84108, USA, - - 2014
Hyperlipoproteinemia type 3 (HLP3) is caused by impaired removal of triglyceride-rich lipoproteins (TGRL) leading to accumulation of TGRL remnants with abnormal composition. High levels of these remnants, called β-VLDL, promote lipid deposition in tuberous xanthomas, atherosclerosis, premature coronary artery disease, and early myocardial infarction. Recent genetic and molecular studies suggest ...
Löwik Marije M MM Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, The - - 2014
Aims: To assess three-year clinical outcome following randomised use of the second-generation Resolute zotarolimus-eluting stent (ZES) and the XIENCE V everolimus-eluting stent (EES). For Resolute ZES and randomised use, outcome data ≥3 years are relatively scarce. Methods and results: The TWENTE trial examined 1,391 patients with stable angina or non-ST-elevation ...
Kraak Robin P RP AMC Heartcenter, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
Aims: To report procedural and midterm clinical outcomes after the use of the second-generation Absorb everolimus-eluting bioresorbable vascular scaffold (Absorb BVS) in a real-world percutaneous coronary intervention (PCI) registry. Methods and results: All patients assigned to treatment with the Absorb BVS in the Academic Medical Center, Amsterdam, between August 2012 ...
Li Chuo - - 2014
BackgroundExecutive dysfunction has been observed in patients with left-sided anterior corona radiata infarction. However, whether left-sided posterior corona radiata infarction could cause executive dysfunction is unclear. Also, whether secondary damage in the left frontal white matter following ipsilateral posterior corona radiata infarct is causal or not and contributes to the ...
Lønborg Jacob J Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, - - 2014
To evaluate the clinical importance of the ST peak phenomenon during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Continuous ST monitoring was performed in 942 STEMI patients from arrival until 90 minutes after revascularisation. ST peak was defined as ≥1 mm increase in the ...
Puchner Stefan B SB Department of Radiology and Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Biomedical Imaging and Image-Guided Therapy, Medical University Vienna, Vienna, - - 2014
It is not known whether high-risk plaque, as detected by coronary computed tomography angiography (CTA), permits improved early diagnosis of acute coronary syndromes (ACS) independently to the presence of significant coronary artery disease (CAD) in patients with acute chest pain. The primary aim of this study was to determine whether ...
Edwards Nicola C NC School of Clinical and Experimental Medicine, University of Birmingham; Department of Cardiology, University of Birmingham and Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom - - 2014
-The optimum timing of surgery in asymptomatic patients with chronic severe primary degenerative mitral regurgitation (MR) remains controversial and further markers are needed to improve decision-making. There are limited data that wall stress is increased in MR and may result in ventricular fibrosis. We investigated the hypothesis that chronic volume ...
Agüero Fernando F Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain Infectious Diseases Service, Hospital Clinic - IDIBAPS, University of Barcelona, - - 2014
To analyse differences in myocardial infarction incidence, mortality and hospitalization rates, 28-day case-fatality and two-year prognosis using two myocardial infarction case definitions: the classical World Health Organization definition (1994) and the European Society of Cardiology/American College of Cardiology definition (2000), which added cardiac troponin as a diagnostic biomarker. Population-based cohort ...
Kim Eric S ES Department of Psychology, University of Michigan, Ann Arbor, Michigan, - - 2014
The main strategy for alleviating heart disease has been to target individuals and encourage them to change their health behaviours. Although important, emphasis on individuals has diverted focus and responsibility away from neighbourhood characteristics, which also strongly influence people's behaviours. Although a growing body of research has repeatedly demonstrated strong ...
Cavender Matthew A MA TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, - - 2014
Bivalirudin is an alternative to heparin in patients undergoing percutaneous coronary intervention (PCI). We aimed to define the effects of a bivalirudin-based anticoagulation regimen compared with a heparin-based anticoagulation regimen on ischaemic and bleeding outcomes. We searched Medline, the Cochrane Library, and relevant meeting abstracts (search done on April 9, ...
Corsini Anna A Institute of Cardiology, Cardio-Thoraco-Vascular Department, Sant'Orsola-Malpighi Hospital and University of Bologna, - - 2014
The use of high-sensitivity cardiac Troponin T (hs-cTnT) assay might lead to overdiagnosis and overtreatment of Acute Coronary Syndromes (ACS). This study assessed the epidemiological, clinical and prognostic impact of introducing hs-cTnT in the everyday clinical practice of an Emergency Department. We compared all consecutive patients presenting with suspected ACS ...
Secundo Junior Jose Alves JA Universidade Federal de Sergipe, Aracaju, SE, - - 2014
Background: According to some international studies, patients with acute coronary syndrome (ACS) and increased left atrial volume index (LAVI) have worse long-term prognosis. However, national Brazilian studies confirming this prediction are still lacking. Objective: To evaluate LAVI as a predictor of major cardiovascular events (MCE) in patients with ACS during ...
Romero-Farina Guillermo G Cardiology Department, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Paseo Vall d'Hebron 119-129, 08035, Barcelona, Spain, - - 2014
To assess different warranty periods following a normal myocardial perfusion SPECT based on patients' clinical characteristics and the type of stress performed. A study was done of 2,922 consecutive patients (62.9 ± 13 years; 53.4% women) with a normal stress-rest SPECT. The warranty period was defined as the period during which patients remained ...
Tudela Raúl R CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain. Electronic address: - - 2014
Middle cerebral artery occlusion (MCAO) in rodents causes brain infarctions of variable sizes that depend on multiple factors, particularly in models of ischemia/reperfusion. This is a major problem for infarct volume comparisons between different experimental groups since unavoidable variability can induce biases in the results and imposes the use of ...
Danchin Nicolas N Cardiology, European Hospital Georges-Pompidiou, Paris, France. Electronic address: - - 2014
Improvements in the treatment of coronary artery disease mean that an increasing number of patients survive acute cardiovascular events and live as outpatients with or without anginal symptoms. To determine the characteristics and management of contemporary outpatients with stable coronary artery disease in Western Europe, and to compare France with ...
Naumenko S E SE Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia, - - 2014
We studied the dynamics of interstitial serotonin during local myocardial ischemia under conditions of ischemic preconditioning in Wistar rats. Ischemic preconditioning increased serotonin content in the dialysate (p=0.003). During 30-min ischemia, ischemic preconditioning delayed serotonin increase just before the 20th min of ischemia. Ischemic preconditioning promoted short-term increase in the ...
Thackeray James T JT Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, - - 2014
ᅟ: Imaging of inflammation early after myocardial infarction (MI) is a promising approach to the guidance of novel molecular interventions that support endogenous healing processes. (18)F-FDG PET has been used, but may be complicated by physiological myocyte uptake. We evaluated the potential of two alternative imaging targets: lactoferrin binding by ...
Freixa Xavier X Division of Cardiology and Cardiovascular Surgery, Montreal Heart Institute, University of Montreal, Montreal, Quebec, - - 2014
Structured Abstract OBJECTIVES: The objective of the present study was to assess if the presence and severity of CAD is associated with decreased LVEF recovery after TAVI. BACKGROUND:Coronary artery disease (CAD) and low left ventricular ejection fraction (LVEF) are common findings in patients undergoing transcatheter aortic valve implantation (TAVI). The ...
Katsikis Athanasios A Nuclear Medicine Department, Onassis Cardiac Surgery Center, Greece. Electronic address: - - 2014
Although Duke treadmill score (DTS) is the most widely used risk stratification method in younger patients undergoing exercise treadmill test (ETT) its specific value in the elderly is not established. 137 patients aged ≥80 years who underwent ETT myocardial perfusion imaging (MPI) were studied. DTS and MPI (including summed stress ...
Nikolić Dalibor D Faculty of Engineering, University of Kragujevac, Sestre Janjic 6, 34000 Kragujevac, Serbia; Bioengineering Research and Development Center - BioIRC, Prvoslava Stojanovića 6, 34000 Kragujevac, - - 2014
This study was performed to evaluate the influences of the myocardial bridges on the plaque initializations and progression in the coronary arteries. The wall structure is changed due to the plaque presence, which could be the reason for multiple heart malfunctions. Using simplified parametric finite element model (FE model) of ...
Kamiya Kiwamu K Department of Cardiovascular Medicine, Hokkaido University Graduate School of - - 2014
Background:Fractional flow reserve (FFR) measured on catheterization is now widely used for the diagnosis of functional myocardial ischemia in patients with coronary artery disease (CAD). FFR, however, is invasive and carries potential procedural complications. Therefore, the aim of this study was to compare the diagnostic capability in functionally significant stenosis ...
Steg Philippe Gabriel PG Université Paris-Diderot, Sorbonne Paris-Cité, Paris, France2Unit 1148, Institut National de la Santé et de la Recherche Médicale, Paris, France3Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodeling), Department of Cardiology, - - 2014
In the era of widespread revascularization and effective antianginals, the prevalence and prognostic effect of anginal symptoms and myocardial ischemia among patients with stable coronary artery disease (CAD) are unknown. To describe the current clinical patterns among patients with stable CAD and the association of anginal symptoms or myocardial ischemia ...
Demirel Fatma F Isala Hospital, Department of Cardiology, Zwolle, The - - 2014
Pre-hospital life-threatening ventricular tachycardia/fibrillation (VT/VF) is relatively common in the acute phase of ST-elevation myocardial infarction (STEMI). We evaluated the prognostic impact of out-of-hospital cardiac arrest (OHCA) due to VT/VF in non-selected patients with STEMI admitted for primary percutaneous coronary intervention (PCI). Prospective hospital registry was used to collect data ...
Consuegra-Sánchez Luciano L Servicio de Cardiología, Hospital General Universitario de Santa Lucía, Cartagena, Murcia, España. Electronic address: - - 2014
The impact of atrial fibrillation on the prognosis of myocardial infarction is still the subject of debate. We analyzed the influence of previous and new-onset atrial fibrillation on in-hospital and long-term prognosis in patients with acute myocardial infarction. Prospective study of 4284 patients with ST-segment elevation acute myocardial infarction. We ...
Consuegra-Sánchez Luciano L Servicio de Cardiología, Hospital General Universitario de Santa Lucía, Cartagena, Murcia, Spain. Electronic address: - - 2014
The impact of atrial fibrillation on the prognosis of myocardial infarction is still the subject of debate. We analyzed the influence of previous and new-onset atrial fibrillation on in-hospital and long-term prognosis in patients with acute myocardial infarction. Prospective study of 4284 patients with ST-segment elevation acute myocardial infarction. We ...
Amoogzar Hamid H Division of Pediatric Cardiology, Shiraz University of Medical Sciences, Shiraz, - - 2014
The aim of this study was to evaluate the left ventricular systolic and diastolic function before and after transcatheter percutaneous patent ductus arteriosus (PDA) closure. 21 children (age >6 months old) diagnosed with hemodynamically significant PDA underwent percutaneous PDA closure. Conventional, Doppler and tissue Doppler imaging and speckled-derived strain rate echocardiography ...
Sado Daniel M DM The Heart Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, - - 2014
To explore the use and reproducibility of magnetic resonance-derived myocardial T1 mapping in patients with iron overload. The research received ethics committee approval and all patients provided written informed consent. This was a prospective study of 88 patients and 67 healthy volunteers. Thirty-five patients underwent repeat scanning for reproducibility. T1 ...
Verrier Richard L RL Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston, MA. Electronic address: - - 2014
If channels are functionally expressed in atrioventricular (AV) nodal tissue. Objective: We addressed whether the prototypical If inhibitor, ivabradine, at clinically safe concentrations can slow AV node conduction to reduce ventricular rate (VR) during atrial fibrillation (AF). Effects of ivabradine (0.1 mg/kg, i.v., bolus) were studied in an anesthetized Yorkshire ...
Limbruno U U Misericordia Hospital , ASL 9 Grosseto , - - 2014
Background: The effectiveness of bivalirudin in patients undergoing percutaneous coronary intervention for acute myocardial infarction has been tested in clinical trials, but its use in a real-world scenario has never been reported. Methods: From the total number of patients enrolled in the EUROVISION registry, 678 subjects affected by ST-elevation myocardial ...
Jahnke Cosima C Department of Cardiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany - - 2014
To determine the association between coronary vessel wall morphology and haemodynamic consequences to the myocardium using a combined cardiovascular magnetic resonance (CMR) imaging protocol. Non-invasive CMR profiling of coronary atherosclerotic wall changes and related myocardial blood flow impairment has not been established yet. Sixty-three patients (45 men, 61.5 ± 10.7 ...
Poulin Frédéric F Peter Munk Cardiac Center, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address: - - 2014
Impaired left ventricular (LV) myocardial deformation is associated with adverse outcome in patients with severe aortic stenosis (AS). The aim of this retrospective study was to assess the impact of transcatheter aortic valve implantation (TAVI) on the recovery of myocardial mechanics and the influence of postprocedural aortic regurgitation (AR). Speckle-tracking ...
Liang Jackson J JJ Department of Internal Medicine, Mayo Clinic, Rochester, MN, - - 2014
Recent guidelines for implantable cardioverter-defibrillator (ICD) use in patients with early ventricular arrhythmia (VA) after acute myocardial infarction (MI) are based on systolic function and revascularization status, yet decision to implant an ICD remains highly subjective. We aimed to determine characteristics, utilization of ICDs, and long-term outcomes of survivors of ...
Tsibouris Panagiotis P Panagiotis Tsibouris, Panagiota Mavrogianni, Gastroenterology Department, NIMTS General Hospital, 11521 Athens, - - 2014
To define the significance of ischemic heart disease (IHD) (stable angina to infarction) co-existance in Barrett esophagus (BE) patients and patients with esophageal adenocarcinoma (AdE). All BE/AdE patients in Blackpool-Wyre-Fylde area and Trikala prefecture identified from medical records. Patient clinical details were obtained from hospital and General Practitioner records. Additional ...
Bagai Akshay A From the Terrence Donnelly Heart Center, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (A.B., A.N.C.); Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (Y.W., J.P.C., R.L.M.); Duke Clinical Research Institute, Durham, NC (T.Y.W., E.D.P., C.B.G., M.T.R., K.P.A.); Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor (H.S.G.); New York University School of Medicine (B.S.); NorthShore University Health System, Evanston, IL (J.F.S.); and Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA (D.L.B.). - - 2014
Although randomized clinical trials have compared clopidogrel with higher potency ADP receptor inhibitors (ADPris) among patients with myocardial infarction, little is known about the frequency and factors associated with switching between ADPris in clinical practice. We studied 47 040 patients with myocardial infarction treated with percutaneous coronary intervention, who received ...
Vieira de Melo Rodrigo Morel - - 2014
We aim to evaluate in-hospital events and long-term clinical outcomes in patients over 60 years of age with stable coronary artery disease and preserved left ventricular ejection fraction undergoing off-pump or on-pump coronary artery bypass grafting. The MASS III was a single-center randomized trial that evaluate 308 patients with stable ...
Caretta Giorgio G Department of Cardiology, A.O. "Istituti Ospitalieri" di Cremona, Cremona, - - 2014
Elderly patients are at high risk of mortality when they present with ST-elevation myocardial infarction (STEMI). However, few data exist about prognostic factors in this sub-group when treated with primary percutaneous coronary intervention (pPCI). To assess outcome and predictors of mortality among patients aged >80 years treated with pPCI. We evaluated ...
Lieb Wolfgang W Framingham Heart Study, Framingham, Massachusetts; Institute of Epidemiology, Christian-Albrechts-University Kiel, Kiel, - - 2014
This study sought to evaluate pattern and clinical correlates of change in left ventricular (LV) geometry over a 4-year period in the community; it also assessed whether the pattern of change in LV geometry over 4 years predicts incident cardiovascular disease (CVD), including myocardial infarction, heart failure, and cardiovascular death, ...
Okada Takuya T Department of General Medicine, Odawara Municipal - - 2014
The association between the urinary albumin-to-creatinine ratio (UACR) and target lesion revascularization (TLR) is unknown in patients who are implanted with drug-eluting stents (DESs) or bare metal stents (BMSs) for the treatment of coronary artery disease. Of 231 Japanese patients who were implanted with DESs and/or BMSs during percutaneous coronary ...
Yoneyama Kihei K Division of Cardiology, Department of Internal Medicine, St. Marianna University School of - - 2014
Whether additional intracoronary acetylcholine (ACH) injections are required for severe coronary spasm without limited coronary flow in the ACH provocation test remains unclear. We used (123)I-β-methyl-iodophenyl pentadecanoic acid ((123)I-BMIPP) to identify myocardial ischemic memory to compare the severity of myocardial fatty acid dysmetabolism among Thrombolysis in Myocardial Infarction (TIMI) grade ...
Luz André A aDepartment of Cardiology, Porto Hospital Center bInstitute of Biomedical Sciences of 'Abel Salazar' cDepartment of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, - - 2014
Preinfarction angina (PIA) may play a protective role in patients with ST-elevation myocardial infarction. Data on the relationship between PIA and time to reperfusion are scarce. We aimed to assess infarct size by peak troponin-T (TnT) in patients with or without PIA in three different time intervals to a primary ...
Kwon Deborah H DH Heart and Vascular Institute and Imaging Institute, Cleveland Clinic, Cleveland, OH - - 2014
-Infarct heterogeneity has been shown to be independently associated with adverse outcomes in previous smaller studies. However, it is unknown if infarct characterization is an independent predictor of all-cause mortality in patients with advanced ischemic cardiomyopathy (ICM), after adjusting for clinical risk factors, severity of ischemic mitral regurgitation, incomplete revascularization, ...
Codner Pablo P Beilinson Hospital - Rabin Medical Center, Jabotinski St. 39, Petach Tikva, 39100, Israel. - - 2014
Second-generation drug eluting stent (DES) implantation gradually replaced the first-generation DES in clinical practice. Whether the new DESs in use differ from one another, in terms of clinical outcomes, is still not known. We explored potential differences among DESs. We followed 9584 consecutive patients undergoing percutaneous coronary intervention at our ...
Sofia Renato Rodrigues RR Programa de Pós-graduação em Ciências da Reabilitação, Universidade Nove de Julho, São Paulo, SP, - - 2014
Background: Gender can influence post-infarction cardiac remodeling. Objective: To evaluate whether gender influences left ventricular (LV) remodeling and integrin-linked kinase (ILK) after myocardial infarction (MI). Methods: Female and male Wistar rats were assigned to one of three groups: sham, moderate MI (size: 20-39% of LV area), and large MI (size: ...
Goel Pravin K PK Departments of Cardiology (Drs. Bhatia, Garg, Goel, Kapoor, Kumar, and Tewari) and Nuclear Medicine (Drs. Barai, Gambhir, Jain, Madhusudan, Murthy, and Pradhan), Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, - - 2014
The ideal management of stable patients who present late after acute ST-elevation myocardial infarction (STEMI) is still a matter of conjecture. We hypothesized that the extent of improvement in left ventricular function after successful revascularization in this subset was related to the magnitude of viability in the infarct-related artery territory. ...
Callender Thomas T The George Institute for Global Health, University of Oxford, Oxford, United - - 2014
Heart failure places a significant burden on patients and health systems in high-income countries. However, information about its burden in low- and middle-income countries (LMICs) is scant. We thus set out to review both published and unpublished information on the presentation, causes, management, and outcomes of heart failure in LMICs. ...
Takahashi Yoshimasa Y Department of Radiological Technology, Showa University Fujigaoka - - 2014
In this study we analyzed the influence of region of interest (ROI) selection on the uptake ratio of the liver to the liver plus heart at 15 min (LHL15) during (99m)Tc-galactosyl human serum albumin (GSA) scintigraphy and determined the optimal ROI by evaluating the individual effects of different ROIs in ...
Gimelli Alessia A Fondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, 56124, Pisa, Italy, - - 2014
A relationship between left ventricular (LV) contractile impairment and myocardial perfusion abnormalities has been suggested. Three-hundred and thirty-seven patients underwent myocardial perfusion imaging at CZT and coronary angiography. On scintigraphic images, the summed difference score (SDS) and LV-ejection fraction (EF) were computed. Patients were categorized as follows: Group-1 (LV-EF < 40%; 71 ...
Ohlmeier C C Prof. Dr. Edeltraut Garbe, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Head of Department of Clinical Epidemiology, Achterstraße 30, 28359 Bremen, - - 2014
Objectives: To compare the quality of care regarding the use of elective percutaneous coronary interventions (PCIs) in the inpatient and outpatient setting and to evaluate different methods of confounder control in this context. Methods: Based on data of three statu- tory health insurances including more than nine million insurance members, ...
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