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Ebeling Barbier Charlotte C Department of Radiology, Uppsala University, Uppsala, Sweden; - - 2014
Late enhancement MRI (LE-MRI) and cardiac troponin I (cTnI) are sensitive methods to detect subclinical myocardial injury. We sought to investigate the relation between plasma concentrations of cTnI measured with a high-sensitivity assay (hs-cTnI) and the development of unrecognized myocardial infarctions (UMIs) detected with LE-MRI. After approval from the ethics ...
Rosell-Ortiz Fernando F Empresa Pública de Emergencias Sanitarias de Andalucía. Andalusian Health Ministry, Andalucía, - - 2014
Hospital mortality in myocardial infarction ST-elevation myocardial infarction has decreased in recent years, in contrast to prehospital mortality. Our objective was to determine initial complications and factors related to prehospital mortality in patients with acute myocardial infarction with ST segment elevation (STEMI). Observational study based on a prospective continuous register ...
Modolo Rodrigo R Department of Pharmacology, Faculty of Medical Sciences University of Campinas-UNICAMP, Campinas, SP, Brazil; - - 2014
Hypertension is the most prevalent and significant modifiable risk factor for coronary heart disease. A portion of patients with uncontrolled hypertension are considered to have resistant hypertension (RHTN). Myocardial ischemia incidence increases along with blood pressure (BP) levels. However, the prevalence of myocardial ischemia in patients with RHTN, as well ...
Lurie Ido I Shalvata Mental Health Centre, Hod Hasharon, Israel Department of Psychiatry, Sackler Medical School, Tel Aviv University, Israel Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Medical School, Tel Aviv University, Israel - - 2014
Frailty is a multidimensional geriatric syndrome that indicates increasing vulnerability and decreasing resistance to stressors. Social support (SS) is linked both to cardiovascular disease and to frailty. However, few cohort studies evaluated SS as a potential predictor of frailty, and none involved coronary disease populations. The aim of this study ...
Ermis Peter P Department of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Tex, - - 2014
The objectives of this study are to assess current management algorithms for left ventricular (LV) hemodynamic and diastolic changes following atrial septal device occlusion in adult patients. Percutaneous closure is now routine for atrial septal defects (ASDs). Previous studies show ventricular size normalization following percutaneous closure. Case reports have discussed ...
Subramanian Subha S From the Framingham Heart Study, MA (S.S., C.L., J.E.H., P.C., M.G.L., S.C., D. L.); Population Sciences Branch (S.S., C.L., P.C., D.L.) and Division of Intramural Research (S.S., C.L., P.C., N.N.M., D. L.), National Heart, Lung, and Blood Institute, Bethesda, MD; The Center of Human Development and Aging, New Jersey Medical School, Rutgers (A.A); Cardiovascular Medicine Section, Department of Medicine, Boston University Medical Center, MA (J.E.H., D.L.); BG Medicine, Inc, Waltham, MA (P.M.); Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston (S.C.); and Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN - - 2014
CXCL12 encodes stromal cell-derived factor 1 α (SDF-1), which binds to the receptor encoded by CXCR4. Variation at the CXCL12 locus is associated with coronary artery disease and endothelial progenitor cell numbers, whereas variation at the CXCR4 locus is associated with leukocyte telomere length, which has been shown to be ...
Karabay Can Yucel CY Cardiology Department, Kartal Kosuyolu Heart and Research Hospital, Istanbul, Turkey, - - 2014
The clinical and angiographic predictors of coronary artery aneurysm (CAA) formation in patients with ST-segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) are not clear. This study aims to assess the predictors of CAA formation after primary PCI. 3,428 patients who underwent PCI for STEMI were ...
Forsha Daniel D Division of Pediatric Cardiology, Duke University Medical Center, Durham, North - - 2014
Progressive heart failure leading to transplantation or death is common in pediatric dilated cardiomyopathy (DCM), and treatment options are limited. Select children with DCM have improved after cardiac resynchronization therapy (CRT), but predicting response is challenging. Nonetheless, considering the frequency of death or transplantation in this population, identifying any candidate ...
Nakamura Ayumi A Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, - - 2014
The objective of this study is to determine whether pentraxin-3 (PTX-3) is clinically a biomarker of inflammation, a player in anti-inflammation, or both with regard to coronary atherosclerosis, we compared levels of PTX-3 with levels of adiponectin in addition to high-sensitivity C-reactive protein (hs-CRP). We enrolled 693 patients (51 % male; ...
Liao Ying Y Department of Cardiology, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, Fujian Province, - - 2014
To examine retrospectively the relationship between acute kidney injury (AKI) and acute myocardial infarction (AMI), and the association between estimated glomerular filtration rate (eGFR) at admission and AKI outcome. AKI was defined as an increase in serum creatinine (SCr) by ≥0.3 mg/dl within 48 h or an increase in SCr to ≥1.5 ...
Nadour Wadih W The Center of Cardiovascular MRI, The Gerald McGinnis Cardiovascular Institute, Temple University, Allegheny General Hospital, Pittsburgh, PA, - - 2014
We hypothesize that infarct detection via EKG is inaccurate as compared to MRI and potentially independent of infarct vs. non-infarct status. This might have implications to societies in which initial cardiovascular testing is uniformly EKG's. Objective: relate EKG-defined scar to cardiovascular MRI (CMR)-defined scar independent of underlying myocardial pathology. 235 ...
Ben-Assa Eyal E 1 Department of Cardiology, Tel Aviv University , Tel Aviv, Israel - - 2014
Abstract Background: Patients hospitalized for an acute myocardial infarction (AMI) are at risk for early readmission. Readmission rates in the community reportedly reach approximately 20%, and 30-day readmission rates have become a quality-of-care marker. Telemedicine is one strategy for improving clinical outcomes by offering real-time biometrics tracking and rapid intervention. ...
Herrett Emily E Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK - - 2014
Ischaemia in different arterial territories before acute myocardial infarction (AMI) may influence post-AMI outcomes. No studies have evaluated prospectively collected information on ischaemia and its effect on short- and long-term coronary mortality. The objective of this study was to compare patients with and without prospectively measured ischaemic presentations before AMI ...
Di Chiara Tiziana T Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, - - 2014
This study was designed to evaluate the prevalence of cardiometabolic comorbidities and the changes in left ventricular geometry and function in 135 subjects subgrouped according to low or normal total adiponectin plasma (ADPN) levels. Left ventricular (LV) internal diameter/height, total LV mass (LVM) and LVM index (LVMI), relative wall thickness ...
Pilgrim Thomas T Department of Cardiology, Bern University Hospital, Bern, - - 2014
The choice and duration of antiplatelet therapy for secondary prevention of coronary artery disease (CAD) is determined by the clinical context and treatment strategy. Oral antiplatelet agents for secondary prevention include the cyclo-oxygenase-1 inhibitor aspirin, and the ADP dependent P2Y12 inhibitors clopidogrel, prasugrel and ticagrelor. Aspirin constitutes the cornerstone in ...
Bavry Anthony A AA North Florida/South Georgia Veterans Health System, Gainesville, Florida; Division of Cardiovascular Medicine, University of Florida, Gainesville, - - 2014
Deferral of revascularization for abnormal but nonischemic lesions is usually recommended; however, the long-term outcome of this approach is not well known. Deferral of nonischemic lesions will be associated with a low frequency of adverse events. A PubMed search of the MEDLINE database identified studies that reported clinical outcomes among ...
Capodanno Davide D Ferrarotto Hospital, University of Catania, Catania, - - 2014
Aims: Clinical data on the early and midterm outcomes of bioresorbable vascular scaffolds (BVS) in routine clinical practice are limited. To fill this gap, we report on the early and midterm clinical outcomes of PCI with everolimus-eluting BVS from the large multicentre GHOST-EU registry. Methods and results: Between November 2011 ...
Soriano Francisco Garcia FG 1Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Instituto de Ortopedia e Traumatologia, São Paulo, Brazil 2Emergências Clínicas do Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil 3Departamento de Anatomia Patológica da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil 4Hospital Universitário da Universidade de São Paulo - Divisão de Clínica Médica - UTI, São Paulo, - - 2014
Sepsis impairs the autoregulation of myocardial microcirculatory blood flow, but whether this impairment is correlated with myocardial remodeling is unknown. This study investigated the role of coronary driving pressure (CDP) as a determinant of microcirculatory blood flow and myocardial fibrosis in endotoxemia and sepsis. The study is composed by two ...
Baig Sheharyar S SS Green Templeton College, University of Oxford, Oxford - - 2014
Revascularization in stable coronary artery disease (CAD) can be achieved through percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) depending on the anatomical pattern of CAD, comorbidities and patient preference. Recent studies in the USA, Canada and Australia show marked local variation in the PCI/CABG ratio that is ...
Uslu Nevzat N Cardiology Department, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, - - 2014
Fragmented QRS (fQRS) has been found to be associated with high mortality and arrhythmic events in acute coronary syndromes. Regional systolic function using wall motion score index (WMSI) is an alternative to left ventricular ejection fraction (LVEF) for the assessment of left ventricular systolic function. The aim of this study ...
Marcantoni Lina L Department of Cardiology, S. Anna Hospital, University of Ferrara, Cona, Ferrara, - - 2014
In the last decade, there has been an exponential increase in cardioverter-defibrillator (ICD) implants. Remote monitoring systems, allow daily follow-ups of patients with ICD. To evaluate the impact of remote monitoring on the management of cardiovascular events associated with supraventricular and ventricular arrhythmias during long-term follow-up. A total of 207 ...
Barutçu Ahmet A Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, - - 2014
Ventricular ectopic beats (VEBs) are usually considered a benign condition that can be managed with conservative measures. Heart rate variability (HRV), which is one of the most important methods for assessing autonomic activity, is a noninvasive, quantitative method of analyzing autonomic effects on the heart. We aimed to investigate the ...
Olsen Mb M Oslo University Hospital, Research Institute of Internal Medicine, Oslo, - - 2014
Accumulation of DNA damage due to impaired base excision repair (BER) may play a role in the pathogenesis of myocardial failure. The DNA glycosylase Neil3 is known to carry out BER during oxidative stress induced DNA damage, but is also thought to have a role in stem cell biology. Based ...
Sandanger O O University of Oslo, Rikshospitalet University Hospital, Research Institute for Internal Medicine, Oslo, - - 2014
NLRP3 is an innate immune receptor that recognizes tissue damage and initiate inflammatory processes: chiefly, upon activation, NLRP3 forms multiprotein complexes with the adaptor protein ASC and caspase-1, termed inflammasomes, which cleaves pro-IL-1β and mediates release of bioactive IL-1β. Thus, NLRP3 activation may lead to further tissue damage. Hence, we ...
Sénéchal Martin M Manitoba Institute of Child Health, Winnipeg, MB, Canada Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, MB, - - 2014
The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). Patients (n = 74) with T2DM and ≥1 additional cardiac risk factor were recruited to participate in this ...
Puri Rishi R Discipline of Medicine, University of Adelaide, Adelaide, Australia Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA C5Research, Cleveland Clinic, Cleveland, OH, - - 2014
While the relationship between epicardial coronary vasomotor reactivity and cardiovascular events is well established, this observation has yet to be evaluated within the left main coronary artery (LMCA) in humans in vivo. Our aims were to test the endothelium-dependent vasomotor properties of the LMCA, and to compare these responses to ...
Iles-Smith Heather H Central Manchester University Hospitals NHS Foundation Trust, Manchester Royal Infirmary, UK - - 2014
Following primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction, some patients are readmitted with potential ischaemic heart disease symptoms. This study investigated the proportion of PPCI patients readmitted due to potential ischaemic heart disease symptoms within six months, and the cause of symptoms and associated factors. A prospective cohort ...
Hale Sharon L SL The Heart Institute of Good Samaritan Hospital, 1225 Wilshire Blvd, Los Angeles, CA, 90017, USA, - - 2014
The no-reflow phenomenon occurs when an epicardial coronary artery is reopened following myocardial infarction, but portions of the intramural microvasculature fail to reperfuse. One potential mechanism for this is the presence of fibrin tactoids. In addition, some recent studies have suggested that dabigatran treatment may be associated with increased incidence ...
Body Richard R The University of Manchester, Manchester, UK Central Manchester University Hospitals Foundation NHS Trust, Manchester Academic Health Science Centre, Manchester, - - 2014
To determine the diagnostic accuracy of emergency physician gestalt in emergency department (ED) patients with suspected cardiac chest pain, both alone and in combination with initial troponin level and ECG findings. We prospectively included patients presenting to the ED with suspected cardiac chest pain. Clinicians recorded their 'gestalt' at the ...
Neven Kars K Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands & Department of Rhythmology, Alfried Krupp Krankenhaus, Essen, Germany - - 2014
-Irreversible electroporation is a promising non-thermal ablation modality able to create deep myocardial lesions. We investigated lesion size after epicardial electroporation catheter ablation with various energy levels following subxiphoid pericardial puncture. -In 6 six-month-old pigs (60-75 kg), a custom deflectable octopolar 12 mm circular catheter with 2 mm ring electrodes ...
Hoong Caroline Wei Shan CW aNational Heart Centre Singapore bDuke NUS Graduate Medical School, - - 2014
Heart failure with preserved ejection fraction (HF-PEF) has been shown to be of better or equivalent prognosis than heart failure with reduced ejection fraction (HF-REF). We aimed to characterize and study the outcome of HF-PEF in a multiethnic South East Asian context. This is a single-centre retrospective analysis of 312 ...
Tenekecioglu Erhan E Department of Cardiology, Bursa Yuksek Ihtisas Education and Resarch Hospital, Bursa, - - 2014
White blood cells are reported as important not only in plaque vulnerability but also in thrombus formation and thrombus growth in acute coronary syndromes. Eosinophils contain granules that promote thrombus formation and thrombus growth in some heart diseases. In this study we aimed to investigate the relation of eosinophil count ...
Verdoia Monica M Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, - - 2014
Eosinophils have been involved in a wide spectrum of pro-inflammatory and pro-thrombotic conditions, with the development of cardiovascular complications in a significant proportion of hypereosinophilic patients. However, no study has so far evaluated the impact of eosinophils levels on periprocedural myocardial infarction (PMI) in patients undergoing non-urgent percutaneous coronary interventions ...
Auguadro Carla C aCardiovascular Catheterization Laboratory, Policlinico di Monza bBiostatistics Unit, Policlinico di Monza cDepartment of Cardiology, Policlinico di Monza, Monza, - - 2014
To assess the prognostic role of isolated troponin I (TnI) elevation after elective percutaneous coronary intervention (PCI) in patients with stable coronary artery disease. The prognostic role of minor troponin elevation after PCI is controversial. A total of 1532 consecutive patients who underwent elective PCI were included. Follow-up data were ...
Lønborg Jacob J Department of Cardiology, Rigshospitalet, University of Copenhagen, Denmark - - 2014
The impact of angiographically visible distal embolization (DE) and distal protection occurring during primary percutaneous coronary intervention (PCI) on long-term outcome has not been studied in a contemporary ST-segment elevation myocardial infarction (STEMI) cohort. To evaluate the association between DE and long-term outcome in STEMI patients treated with primary PCI ...
Kono Atsushi K AK From the Departments of *Radiology, and †Cardiology, Erasmus Medical Center, Rotterdam, the - - 2014
Quantitative myocardial perfusion imaging by computed tomography (CT) was recently introduced to calculate myocardial blood flow (MBF). Because absolute MBF thresholds may be affected by technique, methodology, and the microvasculature, we investigated whether a relative measure of MBF improves accuracy to identify hemodynamically significant coronary stenosis. In this prospective study, ...
Zehir Regayip R Kartal Kosuyolu Heart and Research Hospital, Cardiology Department, Istanbul, - - 2014
Polycystic ovary syndrome (PCOS) is closely related to increased cardiovascular risk in women of reproductive age. Atrial conduction abnormalities in these patients have not been investigated in terms of atrial electromechanical delay measured by tissue Doppler imaging (TDI) as an early predictor of atrial fibrillation development. The aim of this ...
Hori Yuichi Y Department of Cardiology, Dokkyo Medical University Koshigaya - - 2014
Background:Atrial low-voltage areas are suggested to be related to maintenance of atrial fibrillation (AF). The influence of the left atrium (LA) contact area (CoA) has not been investigated.Methods and Results:Twenty-two persistent AF patients underwent high-density mapping during AF and sinus rhythm (SR). Three representative CoA regions in the LA (ascending aorta: anterior ...
Fanning Jonathon P - - 2014
BackgroundCerebral infarction is a commonly observed radiological finding in the absence of corresponding, clinical symptomatology, the so-called silent brain infarction (SBI). SBIs are a relatively new consideration as improved imaging has facilitated recognition of their occurrence. However, the true incidence, prevalence and risk factors associated with SBI remain controversial.MethodsSystematic searches ...
Giglio Vincenzo - - 2014
This study was designed to assess whether cardiovascular magnetic resonance imaging (CMR) in Duchenne muscular dystrophy carriers (DMDc) may index any cell milieu elements of LV dysfunction and whether this cardiac phenotype may be related to genotype. The null hypothesis was that myocardial fibrosis, assessed by late gadolinium enhancement (LGE), ...
Tsutsui Rayji S RS Heart and Vascular Institute, Cleveland Clinic, Cleveland, - - 2014
Several methods that estimate right atrial pressure (RAP) from echocardiographic parameters have been proposed. However, their precision (i.e., how much they decrease RAP estimation uncertainty) is unknown. The aim of this prospective study was to evaluate and compare the precision of previously proposed RAP estimates in patients with acute decompensated ...
Manders Emmy E Department of Pulmonology, Vrije Universiteit (VU) University Medical Center, Amsterdam, the Netherlands; Department of Physiology, VU University Medical Center, Amsterdam, the - - 2014
After lung transplantation, increased left ventricular (LV) filling can lead to LV failure, increasing the risk of post-operative complications and mortality. LV dysfunction in pulmonary arterial hypertension (PAH) is characterized by a reduced LV ejection fraction and impaired diastolic function. The pathophysiology of LV dysfunction in PAH is incompletely understood. ...
Garg Jalaj J Westchester Medical Center, New York Medical College. - - 2014
The pathophysiology of coronary artery dissection (CD) remains poorly understood and little is known about the factors predicting mortality in these patients. We aimed to study the epidemiology of CD and predictors of mortality in these patients. All patients diagnosed with CD in the Nationwide Inpatient Sample 2009 - 2010 ...
Rzeszutko Lukasz - - 2014
Current revascularization guidelines recommend coronary stenting with either bare metal stent (BMS) or drug eluting stent (DES). The results of bioresorbable vascular scaffold (BVS) implantation in the setting of both stable angina or acute coronary syndrome have proven to be both safe and efficacious. Our aim was to describe current ...
Stępińska Janina - - 2014
Heart rate (HR) is an important risk factor in coronary artery disease (CAD). However, there is little contemporary data on HR and the use of HR-lowering medications, particularly beta-blockers, among patients with stable CAD in routine clinical practice. To describe HR in the Polish population of the CLARIFY registry, overall ...
Celik Omer O Department of Cardiology, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey - - 2014
We hypothesized that contrast media volume-estimated glomerular filtration rate (CV-e-GFR) ratio may be a predictor of contrast media-induced acute kidney injury (CI-AKI). We investigated the associations between CV-e-GFR ratio and CI-AKI in 597 patients undergoing primary percutaneous coronary intervention (pPCI). An absolute ≥0.3 mg/dL increase in serum creatinine compared with ...
Reimold Sharon C SC University of Texas Southwestern, Dallas, TX - - 2014
Left ventricular noncompaction cardiomyopathy (LVNC) is a disorder characterized by significant ventricular trabeculations on cardiovascular imaging. The most common echocardiographic criteria used to define the disorder are the Jenni and Chin criteria.(1,2) These criteria were developed after the observation that some patients, primarily children, had cardiomyopathies characterized by significant trabeculations ...
Kumar Prathap P Meditrina Hospital, Trivandrum, - - 2014
Durable polymers used for first-generation drug-eluting stents (DES) potentially contribute to persistent inflammation and late DES thrombosis. We report the first real-life human experience with the rapamycin-eluting biodegradable polymer-coated Rapstrom stent. All consecutive patients with single de novo native coronary stenosis (<30 mm and between 2.5 and 4.0 mm) were enrolled. Major ...
Campos Carlos M CM Department of Interventional Cardiology, Erasmus Medical Centre-University Medical Centre - - 2014
Background:SYNTAX score II (SSII) provides individualized estimates of 4-year mortality after coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in order to facilitate decision-making between these revascularization methods. The purpose of the present study was to assess SSII in a real-world multicenter registry with distinct regional and epidemiological ...
Pusuroglu Hamdi H aDepartment of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital bDepartment of Cardiology, School of Medicine, Bezmialem Vakıf University cDepartment of Cardiology, Acıbadem University, Istanbul dDepartment of Cardiology, Erzurum State Training and Research Hospital, Erzurum eDepartment of Cardiology, Rize Education and Research Hospital, Rize, - - 2014
The aim of this study was to evaluate the prognostic value of soluble CD40 ligand (sCD40L) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing a primary percutaneous coronary intervention (PCI). The prognostic value of sCD40L has been documented in patients with acute coronary syndrome; however, its value in acute ...
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