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Rigolli Marzia M Awhina Health Campus, Waitakere Hospital, Waitemata District Health Board, Private Bag 93-503, Auckland, New Zealand ; Division of Cardiology, University of Verona, Ospedale Maggiore, Ple Stefani 1, 37126 Verona, - - 2013
Progressive aging of the population and prolongation of life expectancy have led to the rising prevalence of heart failure (HF). Despite the improvements in medical therapy, the mortality rate of this condition has remained unacceptably high, becoming the primary cause of death in the elderly population. Almost half of patients ...
Falcão Felipe José de Andrade FJ Department of Cardiology, Universidade Federal de São Paulo, São PauloSP, - - 2013
To identify predictors of in-hospital mortality in patients with acute myocardial infarction undergoing pharmacoinvasive treatment. This was an observational, prospective study that included 398 patients admitted to a tertiary center for percutaneous coronary intervention within 3 to 24 hours after thrombolysis with tenecteplase. ClinicalTrials.gov: NCT01791764 RESULTS: The overall in-hospital mortality ...
Camuglia A C - - 2013
Time to reperfusion is among the strongest predictors of clinical outcome in patients who present with ST elevation acute myocardial infarction. When time to access is equivalent, primary percutaneous coronary intervention has demonstrated superior outcomes to fibrinolysis. However, where significant delays exist in accessing percutaneous intervention, fibrinolysis has an important ...
Dehghani Farnaz F Department of Nursing, Physiology Research Center, Kerman University of Medical Sciences, Kerman, - - 2013
Despite some evidences about protective or triggering role of opium use in patients with coronary artery disease, the exact role of opium is still under question. The current study aimed to address the relation of opium dependence on the severity and extension of myocardial infarction (MI) and its related mortality. ...
Koç Zehra Pınar - - 2013
Since twenty-four-hour imaging by Tl-201 myocardial perfusion scintigraphy has been introduced as an effective additional procedure, the aim of this study was to compare this method's result with only rest redistribution procedure in the diagnosis of myocardial viability. Thirty patients (Seven female, 23 male; mean: 59.8 ± 10.7, 55.8-63.8 years ...
Bhuyan Soumitra Sudip SS Dept. of Health Services Research & Administration, UNMC College of Public Health, 984350 Nebraska Medical Center, Omaha, NE 68198-4350, - - 2013
Acute myocardial infarction (AMI) remains a major cause of death and disability in the United States and worldwide. Despite the importance of surveillance and secondary prevention, the incidence of and mortality from AMI are not continuously monitored, and little is known about survival outcomes after 30 days of AMI hospitalization ...
Shacham Yacov - - 2013
An elevated C-reactive protein (CRP) level is associated with adverse outcomes in patients with acute myocardial infarction (AMI). Although CRP levels have been shown to be associated with left ventricular (LV) systolic function and remodeling in AMI, little is known about their relation to early LV diastolic function. We retrospectively ...
Liebetrau Christoph - - 2013
N-terminal segment of B-type natriuretic peptide prohormone (NT-proBNP) is elevated in patients with acute myocardial infarction (AMI) thus providing both diagnostic information and prognostic information. The aim of the present study was to determine the time course of NT-proBNP release in patients undergoing transcoronary ablation of septal hypertrophy (TASH) a ...
Niccoli Giampaolo - - 2013
Parvovirus (PV) B19 DNA is detected in endothelial cells and may cause endothelial dysfunction which is involved in in-stent restenosis. We aimed at performing an exploratory analysis that evaluated if PVB19 DNA at the culprit coronary stenosis would be associated with an increased rate of major adverse cardiac events (MACE) ...
Brown David A - - 2013
We recently showed that Bendavia, a novel mitochondria-targeting peptide, reduced infarction and no-reflow across several experimental models. The purpose of this study was to determine the therapeutic timing and mechanism of action that underlie Bendavia's cytoprotective property. In rabbits exposed to in vivo ischemia/reperfusion (30/180 min), Bendavia administered 20 minutes ...
Bortnick Anna E AE Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New - - 2013
Management of coronary artery disease (CAD) has evolved over the past decade, but there are few prospective studies evaluating long-term outcomes in a real-world setting of evolving technical approaches and secondary prevention. The aim of this study was to determine how the mortality and morbidity of CAD has changed in ...
Mu Lingmin L Morphological Laboratory, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. - - 2014
The aim of the present study was to examine the expression of N-cadherin in the myocardial tissues of isoproterenol-induced myocardial hypertrophy in rats. In addition, the present study provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse myocardial hypertrophy. A myocardial hypertrophy model was established ...
Gravning Jørgen - - 2013
-The incremental prognostic value of high-sensitive troponin T (hs-cTnT) in heart failure (HF) beyond that of hs-CRP and NT-proBNP is debated. We examined the prognostic value of hs-cTnT in a subgroup of patients from the CORONA study (Controlled Rosuvastatin Multinational Trial in HF). -Hs-cTnT as a risk factor for the ...
Paparella Domenico - - 2013
Myocardial damage occurs after valve surgery, but its prognostic implication has not been evaluated. The aim of the present study was to assess the influence of myocardial damage on mortality and morbidity in patients undergoing aortic surgery (AVS) and mitral valve surgery (MVS). In a prospective multicenter study from the ...
Close Glenn R GR Western Sydney Local Health District, - - 2013
Socioeconomic disadvantage is associated with an increased risk of developing heart failure and with inferior health outcomes following diagnosis. Data for hospitalisations and deaths due to heart failure in the Sydney metropolitan region were extracted from New South Wales hospital records and Australian Bureau of Statistics databases for 1999-2003. Standardised ...
Witzenbichler Bernhard - - 2013
Prior small to modest sized studies suggest a benefit of IVUS guidance in non-complex lesions. Whether IVUS guidance is associated with improved clinical outcomes after drug-eluting stent (DES) implantation in an unrestricted patient population is unknown. ADAPT-DES was a prospective, multicenter, non-randomized "all-comers" study of 8583 consecutive patients at 11 ...
Zeymer U - - 2013
This prospective registry assessed the safety and efficacy of paclitaxel coated balloon (PCB) angioplasty for small vessel coronary artery disease in Europe and Asia with the intention to treat lesions without additional stenting. The use of PCBs in small vessels seems to be associated with favourable outcomes; however, prospective data ...
Philip Femi - - 2013
BACKGROUND: THE RELATIVE SAFETY OF DRUG-ELUTING STENTS (DESS) AND BARE-METAL STENTS (BMSS) WITH RESPECT TO STENT THROMBOSIS (ST) CONTINUES TO BE DEBATED. THERE ARE LIMITED DATA COMPARING SAFETY AND EFFICACY OF SECOND-GENERATION DES TO BMS. WE COMPARED THE CLINICAL OUTCOMES BETWEEN SECOND-GENERATION DES AND BMS FOR PRIMARY PERCUTANEOUS CORONARY INTERVENTION ...
Donkol Ragab Hani RH Ragab Hani Donkol, Radiology Department, Aseer Central Hospital, Abha, Saudi Arabia and Faculty of Medicine, Cairo University, 11559, Cairo, - - 2013
To assess the incidence, location, morphology and clinical association of myocardial bridging in a Saudi population using coronary computed tomographic angiography (CCTA). A total of 350 CCTA of Saudi patients were included in this study (236 men, 114 women) with a mean age of 56.3 years. All patients were examined ...
Levi Amos - - 2013
Limited contemporary data exist regarding the incidence, predictors, and outcomes of failure of primary percutaneous coronary intervention (PCI) in the treatment of ST-segment elevation myocardial infarction (STEMI). In this registry-based retrospective cohort study, all consecutive unselected patients (n=1725) who were hospitalized for STEMI and underwent primary PCI from January 2001 ...
Dores Hélder - - 2013
Percutaneous coronary intervention (PCI) is increasingly used as a treatment option for unprotected left main coronary artery (ULMCA) lesions. We aimed to evaluate the long-term outcome of patients undergoing ULMCA PCI. We retrospectively analyzed 95 consecutive patients (median EuroSCORE I 2.9 [IQR 1.4;6.1]) who underwent ULMCA PCI between 1999 and ...
Edelman J James - - 2013
The balance between hyper- and hypocoagulable states is critical after coronary artery surgery both with (coronary artery bypass grafting [CABG]) and without (off-pump coronary artery bypass [OPCAB]) cardiopulmonary bypass to prevent thrombotic or bleeding complications. We aimed to quantify novel parameters of coagulation, fibrinolysis, and overall hemostasis ≤6 months after ...
Dasari Tarun W TW Department of Internal Medicine, Cardiology Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Electronic address: - - 2013
Secondary prevention trials have demonstrated the efficacy of statins in reducing cardiovascular morbidity and mortality in patients with coronary artery disease and events after percutaneous coronary intervention (PCI). However, there are few data describing the clinical value of statins in patients with coronary artery disease and chronic kidney disease (CKD) ...
Vyas Ankur A Division of Cardiovascular Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa. Electronic address: - - 2013
Drug-eluting stent (DES) in-stent restenosis (ISR) can be treated by restenting using the same DES as previously placed (same stent strategy), versus switching to a stent that elutes a different drug (different stent strategy). To compare the efficacy of these strategies, a meta-analysis of controlled trials and observational studies evaluating ...
Verdecchia Paolo P Department of Medicine, Hospital of Assisi, Assisi, Italy. Electronic address: - - 2013
It is unknown whether left ventricular hypertrophy (LVH) diagnosis by electrocardiography improves risk stratification in patients with atrial fibrillation (AF). We investigated the prognostic impact of LVH diagnosis by electrocardiography in a large sample of anticoagulated patients with AF included in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) Study. ...
Haaf Philip P Department of Internal Medicine, University Hospital, Basel, Switzerland; Department of Cardiology, University Hospital, Basel, - - 2014
Endothelial dysfunction plays a major role in cardiovascular diseases, including acute myocardial infarction (AMI). However, its quantification has not been available as a clinical tool. In a prospective international multicentre study, we analyzed the diagnostic and prognostic utility of endothelial dysfunction as quantified by C-terminal proendothelin-1 (CT-proET-1) in 658 consecutive ...
Rodríguez-Palomares José F JF Department of Cardiology, Hospital Universitari Vall d'Hebron, Vall Hebrón Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: - - 2014
Electrocardiography is an excellent tool for decision making in patients with ST elevation myocardial infarction (STEMI). However, little is known on the correlation between its dynamic changes during primary percutaneous coronary intervention (PCI) and the anatomic information provided by cardiovascular magnetic resonance. The study aimed to assess the predictive value ...
Liu Yuan Hui - - 2013
Contrast-induced acute kidney injury (CI-AKI) is a well-known serious complication of percutaneous coronary intervention (PCI) and may cause increased morbidity and mortality. We aim to identify the predictive value of Global Registry for Acute Coronary Events (GRACE) risk scores for CI-AKI in patients with ST-segment elevation myocardial infarction (STEMI) before ...
Korantzopoulos Panagiotis - - 2013
Objective. Data regarding the effect of lipid parameters on repolarization are sparse. Recent data indicate that reconstituted HDL administration shortens repolarization in cardiomyocytes as well as the corrected QT (QTc) interval in human subjects. We investigated the potential association of high-density lipoprotein cholesterol (HDL-C) levels with conventional and novel electrocardiographic ...
Ding Fang-Bao - - 2013
Background/Aims: Most cardiac procedures involve the use of cardiopulmonary bypass (CPB), which pumps oxygenated blood to the body while the heart and lungs are isolated. CPB can cause profound alterations V in the homeostasis of physiological fluids, which often results in myocardial edema. In our study, we used sheep CPB ...
Marzencki Marcin - - 2013
Rapid restoration of vessel patency after acute myocardial infarction is key to reducing myocardial muscle death and increases survival rates. Standard therapies include thrombolysis and direct PTCA. Alternative or adjunctive emergency therapies that could be initiated by minimally trained personnel in the field are of potential clinical benefit. This paper ...
Sonobe Takashi - - 2013
Calpain activation has a putative role in ischaemia-reperfusion injury of cardiomyocytes. This study clarified the in vivo contribution of calpain to disruption of cardiomyocyte sarcolemma during ischaemia and after reperfusion in anaesthetized rats. Using a microdialysis technique in the hearts of anaesthetized rats, we investigated the effects of the calpain ...
Kerem Yaniv - - 2013
Clinical outcomes in ST-segment elevation myocardial infarction (STEMI) are related to reperfusion times. Given the benefit of early recognition of STEMI and resulting ability to decrease reperfusion times and improve mortality, current prehospital recommendations are to obtain electrocardiograms (ECGs) in patients with concern for acute coronary syndrome. We sought to ...
van Diepen Sean S Divisions of Critical Care and Cardiology, University of Alberta, Edmonton, Alberta, Canada. Electronic address: - - 2014
Symptomatic heart failure (HF) and reduced ejection fraction (REF) are both associated with mortality, but the long-term outcomes associated with the development of HF in older non-ST-segment elevation myocardial infarction (NSTEMI) patients with preserved systolic function and REF are uncertain. We analyzed a total of 26,291 NSTEMI patients ≥65 years ...
Cheng Jin M - - 2013
Acute coronary syndromes (ACS) are mostly caused by plaque rupture. This study aims to investigate the prognostic value of in vivo detection of high-risk coronary plaques by intravascular ultrasound (IVUS) in patients undergoing coronary angiography. Between November 2008 and January 2011, IVUS of a non-culprit coronary artery was performed in ...
Van Belle Eric - - 2013
There is no large report of the impact of fractional flow reserve (FFR) on the reclassification of the coronary revascularization strategy on individual patients referred for diagnostic angiography. The Registre Français de la FFR (R3F) investigated 1075 consecutive patients undergoing diagnostic angiography including an FFR investigation at 20 French centers. ...
De Lorenzo Andrea - - 2013
The aim of this study was to evaluate whether chronotropic incompetence (CI), the inability to reach 85% of the maximal predicted heart rate during exercise, affects the assessment of myocardial ischemia and prognosis in patients undergoing myocardial perfusion single-photon emission computed tomography (MPS). Patients undergoing exercise/rest MPS were studied. Those ...
Trusinskis Karlis - - 2013
The purpose of the study was to evaluate associations between iMap intravascular ultrasound tissue characterization of culprit and nonculprit lesions in infarct-related artery and plasma biomarkers during ST segment elevation myocardial infarction (STEMI) and at 10-month follow-up. Sixty-three STEMI patients at the time of index hospitalization and 10-month follow-up underwent ...
Onorati Francesco - - 2013
Despite demonstration of the superior outcomes of transcatheter aortic valve implantation (TAVI) versus optimal medical therapy for severe left ventricular systolic dysfunction, studies comparing TAVI and surgical aortic valve replacement (AVR) in this high-risk group have been lacking. We performed propensity matching for age, gender, baseline comorbidities, previous interventions, priority ...
Heldman Alan W - - 2013
IMPORTANCE Whether culture-expanded mesenchymal stem cells or whole bone marrow mononuclear cells are safe and effective in chronic ischemic cardiomyopathy is controversial. OBJECTIVE To demonstrate the safety of transendocardial stem cell injection with autologous mesenchymal stem cells (MSCs) and bone marrow mononuclear cells (BMCs) in patients with ischemic cardiomyopathy. DESIGN, ...
Azevedo Rudyney E U - - 2013
Background: The relationship between renal dysfunction and mortality after myocardial infarction (MI) has been demonstrated in patients with reduced ejection fraction. The importance of diastolic dysfunction in this scenario is unknown.
Methods: We studied 749 patients with acute MI who were evaluated within 24 hours of symptom onset. The Modification of ...
Manhenke Cord - - 2013
We investigated the temporal changes in circulating levels of markers of extracellular cardiac matrix (ECCM) turnover and their relationship with infarct size (IS), ejection fraction (EF), and left ventricular (LV) volumes, determined by serial cardiac magnetic resonance (CMR) imaging in patients with first-time ST-elevation myocardial infarction (STEMI). Forty-two patients with ...
Guo Rui-Wei - - 2013
Myocardial necrosis after ST-segment elevation myocardial infarction (STEMI) can cause left ventricular systolic dysfunction, which has been associated with poor outcomes. Some authors have reported that women have higher mortality rates after primary percutaneous coronary intervention (PCI), but differences between the sexes with regard to recovery of ejection fraction (EF) ...
Holdsworth David L - - 2013
Utilization of implantable bio-telemetry devices represents a common approach to contemporary cardiovascular safety assessment. Depending on the specific needs of the study design, and corresponding surgical methodologies employed, application of telemetry devices may have more or less liability to interact with ongoing physiology. The potential for intrathoracic procedures (epicardial/intracardiac ECG ...
Jogestrand Tomas - - 2013
This study aimed to evaluate the effect of standard medical treatment on the progression of atherosclerosis after a myocardial infarction, in an ordinary clinical setting, by measuring the right and left common carotid intima-media thickness (IMT). The first investigation took place 3-12 months after the index event; the second took place ...
Tsai Shane F - - 2013
QT prolongation is a risk factor for proarrhythmia when beginning antiarrhythmic drug therapy (AAD). However, there are no data regarding monitoring repolarization changes during a ventricular paced (VP) rhythm. The purpose of this study is to compare serial changes in corrected QT and JT intervals, during native conduction (NC) and ...
Prendergast Heather M - - 2013
Approximately 50 % of heart failure cases are due to diastolic failure. Generally, it is thought that asymptomatic diastolic dysfunction precedes the development of diastolic heart failure, representing an ideal time for intervention. Previous studies have examined progression rates in non-minority populations only. To determine the rate of diastolic dysfunction progression ...
Kawel-Boehm N - - 2013
To test feasibility of myocardial T1 mapping of the right ventricle (RV) at systole when myocardium is more compact and to determine the most appropriate imaging plane. 20 healthy volunteers (11 men; 33 ± 8 years) were imaged on a 1.5T scanner (MAGNETOM Avanto, Siemens AG, Erlangen, Germany). A modified look-locker inversion-recovery sequence ...
Daidoji Hyuma - - 2013
Aims: Previous studies reported that integrated backscatter intravascular ultrasound (IB-IVUS) provides high diagnostic accuracy for tissue characterization of coronary plaques and that pregnancy-associated plasma protein A (PAPP-A) could be a marker of adverse cardiac outcome in patients with cardiovascular disease. We examined whether IB-IVUS and PAPP-A levels could predict the ...
Apostolakis Stavros - - 2013
Echocardiographically determined left ventricular hypertrophy (LVH) is a marker of cardiovascular disease related to prognosis and clinical outcomes. We sought to determine if LVH is a measure of outcomes in atrial fibrillation (AF) patients. We performed a post-hoc analysis of patients with echocardiographic data enrolled in the Atrial Fibrillation Follow-up ...
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