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Daniels Lori B LB Division of Cardiology, Department of Medicine, University of California at San Diego, Mail Code 7411,9444 Medical Center Drive, La Jolla, CA, 92037-7411, USA, - - 2014
Cardiac troponin assays have an established and undisputed role in the diagnosis and risk stratification of patients with acute myocardial infarction. As troponin assays gets more sensitive and more precise, the number of potential uses has rapidly expanded, but the use of this test has also become more complicated and ...
Rahman Atifur A School of Medicine, Gold Coast Campus, Griffith University, Gold Coast, Queensland, Australia; Department of Cardiology, Gold Coast University Hospital, Gold Coast, Queensland, - - 2014
Troponin is a highly sensitive biomarker of myocardial injury and has been used extensively in everyday clinical practice in the community as well as in hospitals for the diagnosis of acute myocardial infarction (AMI) and for risk stratification of patients with acute coronary symptoms. Dynamic elevations in biomarkers (troponin) are ...
Tamis-Holland Jacqueline E JE Department of Medicine, Division of Cardiology, Mount Sinai St Luke's Hospital, New York, New - - 2014
ST-segment elevation myocardial infarction (STEMI) is considered a cardiology emergency requiring immediate recognition and treatment aimed at successful and early reperfusion to ensure optimal outcomes. The American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA) have issued guidelines for the diagnosis and management of patients with acute ...
Suryanarayana Jandhyala J Department of Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, - - 2014
A 65-year-old woman, treated for non-ST segment elevation myocardial infarction and unexplained type 2 respiratory failure, was referred to our hospital in view of difficulty in weaning off the ventilator. She was evaluated in detail for persistent hypercapnia. Ultrasound of the diaphragm showed minimal excursion of diaphragm while she was ...
Kobayashi Junpei - - 2013
The location of white matter lesions, especially in the anterior temporal poles (ATP), is helpful in the diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We report a 49-year-old man with CADASIL who developed migraine with atypical aura, silent lacunar infarcts, and leukoencephalopathy without involvement of ...
Liu Yuan F - - 2013
IMPORTANCE Although infarction after fine-needle aspiration (FNA) is a rare occurrence, it is a known phenomenon that may lead to difficulties in interpretation for pathologists and in decision-making for head and neck surgeons. OBJECTIVE To characterize our experience with infarction in papillary thyroid carcinomas (PTCs) after FNA and review existing ...
Zaya Melody M Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, - - 2014
Coronary spasm is an important and often overlooked etiology of chest pain. Although coronary spasm, or Prinzmetal's angina, has been thought of as benign, contemporary studies have shown serious associated adverse outcomes, including acute coronary syndrome, arrhythmia, and death. Definitive diagnosis of coronary spasm can at times be difficult, given ...
Kuruvilla Sujith - - 2013
Coronary microvascular dysfunction (CMD) also known as syndrome X, is characterized by typical anginal symptoms, evidence of myocardial ischemia on non-invasive testing and normal to minimal coronary disease on coronary angiography. It has a female preponderance and has been detected in up to 50% of women presenting with chest pain ...
Fett James D - - 2013
Peripartum cardiomyopathy (PPCM) has a remarkable potential for recovery. It may be within our capability to help almost all women with PPCM not only to survive, but also to completely recover heart function. Time-of-diagnosis left ventricular ejection fraction (LVEF) ≥0.35 is associated with better survival rates and higher full recovery ...
Bourgeois Caroline - - 2013
The diagnosis of non ST elevation myocardial infarction (NSTEMI) is very important for the emergency doctor. According to the literature copeptin, a marker of the endogenous stress, combined with troponin could be of interest in this diagnosis. The objective of the study was to investigate the association of high-sensitivity (HS) ...
Recchioni Rina - - 2013
Abstract Biomarkers play a critical role in the diagnosis of acute myocardial infarction (AMI), especially in patients with atypical clinical and/or electrocardiographic presentation or co-morbidities, like the elderly. High-sensitivity assays based on specific biomarkers (e.g. cardiac troponins) enabling earlier AMI diagnosis have recently become available in clinical practice. Although no ...
Christenson Eric - - 2013
Myocardial infarction (MI) is the leading cause of death in the developed world. Biomarkers have an essential role in diagnosis, risk stratification, guiding management and clinical decision making in the setting of patients presenting with signs and symptoms of MI. Cardiac troponin (cTn) rose to prominence during the 1990s and ...
Gershlick Anthony H - - 2013
In the past ten years, primary percutaneous coronary intervention (PCI) has replaced thrombolysis as the revascularisation strategy for many patients presenting with ST-segment elevation myocardial infarction (STEMI). However, delivery of primary PCI within evidence-based timeframes is challenging, and health-care provision varies substantially worldwide. Consequently, even with the ideal circumstances of ...
Becher Peter Moritz - - 2013
Introduction: Heart failure with preserved ejection fraction (HFPEF) is a common syndrome, accounting for about 50% of all patients with heart failure (HF). Morbidity and mortality are similar to patients with HF with reduced ejection fraction (HFREF), yet no effective treatment has been identified in randomized clinical trials. Areas covered: ...
Xu Bo - - 2013
Myocardial infarction has a high rate of morbidity and mortality. There are major social, psychological and legal implications associated with the diagnosis of myocardial infarction (MI). We present three case studies of different chest pain syndromes presenting with serum troponin elevation, and use these cases to form the basis of ...
Deddens J C - - 2013
Small non-coding microRNAs (miRNAs) are important physiological regulators of post-transcriptional gene expression. miRNAs not only reside in the cytoplasm but are also stably present in several extracellular compartments, including the circulation. For that reason, miRNAs are proposed as diagnostic biomarkers for various diseases. Early diagnosis of acute coronary syndrome (ACS), ...
Bjurman Christian - - 2013
To examine the extent of change in Troponin T levels in patients with non-ST-elevation myocardial infarction (NSTEMI). Changes in cardiac troponin levels are required for the diagnosis of NSTEMI, according to the new universal definition of acute myocardial infarction. A relative change of 20-230 % and an absolute change of ...
Low Ting-Ting - - 2013
We aimed to determine if timing of polysomnography (PSG) influences the diagnosis of obstructive sleep apnea (OSA) in acute myocardial infarction (AMI) or stable coronary artery disease (CAD). A total of 160 patients admitted with AMI or stable CAD were consecutively recruited for either in-hospital (n=80) or postdischarge (n=80) PSG. ...
Behnke Stefanie - - 2013
The diagnosis of idiopathic Parkinson's disease (IPD) is based on clinical criteria. In the last two decades several neuroimaging methods using transcranial sonography (TCS) or radiolabelled tracers such as the myocardial MIBG scintigraphy were applied to support diagnosis of IPD. They have been used independently of each other and their ...
Karumbaiah Keerthana - - 2013
BACKGROUND: In the diagnosis of acute myocardial infarction (AMI), the presence of baseline left bundle branch block or a permanent pacemaker rhythm poses a challenge. OBJECTIVE: We present a case report highlighting this challenge, along with a review of pertinent literature. CASE REPORT: A 70-year-old female with known severe idiopathic ...
Makaryus John N - - 2013
Early detection of decompensated heart failure enables clinicians to tailor medical therapy to individual patient needs. The utility of transthoracic impedance assessment in the early diagnosis of volume overload has been documented in the literature. We describe the case of a young woman without congestive heart failure who was noted ...
Bae Myung Hwan - - 2013
Rapid diagnosis of ST-segment elevation myocardial infarction (STEMI) is essential for the appropriate management of patients. We investigated the prevalence, etiologies and predictors of false-positive diagnosis of STEMI and subsequent inappropriate catheterization laboratory activation in patients with presumptive diagnosis of STEMI. Four hundred fifty-five consecutive patients (62±13 years, 345 males) ...
Shah Ashok J - - 2013
OBJECTIVES: We prospectively evaluated the role of a novel three-dimensional(3D), non-invasive, beat by beat mapping system, Electrocardiographic Mapping(ECM), in facilitating the diagnosis of atrial tachycardias(AT). BACKGROUND: Conventional 12-lead electrocardiogram, a widely used non-invasive tool in clinical arrhythmia practice, has diagnostic limitations. METHODS: Various ATs (de novo and post atrial fibrillation(AF) ...
Ter Haar C Cato - - 2013
BACKGROUND: The ECG is important in the diagnosis and triage of the acute coronary syndrome (ACS), especially in the hyperacute phase, the "golden hours," during which myocardial salvage possibilities are largest. An important triaging decision to be taken is whether or not a patient requires primary PCI, for which, as ...
Huang Wei-Lin - - 2013
The clinical diagnosis and treatment of ischemia mitral regurgitation (IMR) remained difficult because of its unclear mechanisms. This paper reviews studies on the mechanisms of IMR during the last 20 years, and discusses the relevance of the various mechanisms. Data used in this review were mainly from CNKI and Pubmed ...
Echavarría-Pinto Mauro - - 2013
Thin cap fibroatheromas (TCFAs) are thought to be the most common underlying substrate in patients suffering acute coronary thrombotic events. Recently, an interesting association between TCFAs and a particular depot of visceral fat called epicardial adipose tissue (EAT) has been suggested. In this article, we discuss some basic and clinical ...
Hoffmayer Kurt S - - 2013
Idiopathic ventricular tachycardia (VT) refers to VT occurring in structurally normal hearts. It is commonly seen in young patients and typically has a benign course. Because the origin is typically focal and the heart is without scar, the 12-lead electrocardiogram is extremely useful for localizing the origin of idiopathic VT. ...
Wettersten Nicholas - - 2013
Dynamic ischemic-type electrocardiographic T-wave inversions raise the possibility of myocardial ischemia or infarction but are actually a nonspecific finding. We present a case of a young man presenting with headache and dizziness found to have marked hypertension, deepening T-wave inversions, and troponin elevation. Initial concerns were for acute coronary syndrome ...
Caglar I - - 2013
Hypertrophic cardiomyopathy is a well-known clinical entity. Hypertrophy engraving the left ventricular apex, so called, apical hypertrophic cardiomyopathy (characterized by the giant negative T waves at ECG and a «spade-like» view of left ventricle) is very rare variant of the pathology. In this report, we present a 51-year-old patient with ...
Cheng Luyang - - 2013
The aim of this study was to evaluate the diagnostic value of 64-multislice spiral computed tomography (64-MSCT) for coronary stenosis compared with selective X-ray coronary angiography (SCA). Patients with chest pain, chest tightness or coronary stenosis received SCA and they acted as the controls. The sensitivity and accuracy of 64-MSCT ...
Lippi Giuseppe - - 2013
Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. An early and accurate diagnosis of IHD is necessary to improve outcomes. According to recent guidelines, the diagnosis of acute myocardial infarction (AMI) is based on increased or decreased value of cardiospecific troponins with one measure exceeding ...
Sousa Olga - - 2013
Isolated left ventricular noncompaction (LVNC) is a rare cardiomyopathy characterized by excessive and prominent trabeculations associated with deep recesses that communicate with the ventricular cavity. Determining the natural history of this condition has been hampered by differences in clinical features and prognosis in published series, which are partly the result ...
MÅ‚ynarska Agnieszka - - 2013
New visualization methods are helpful in the noninvasive diagnosis of heart diseases. However, sometimes epicardial and endocardial leads can cause problems due to a large number of artifacts. Based on the presented case, we conclude that it is possible to perform multi-slice computed tomography of coronary arteries despite the coexistence ...
Piyanuttapull Sumitra - - 2013
Patients present with chest pain. Electrocardiography (ECG) is used and troponin-T levels slowly increases. Diagnosis of myocardial infarction requires prolonged monitoring, over six to nine hours, for serial blood sampling. It is the cause of delayed treatment and lead to a crowded emergency room. Troponin is a marker of myocardial ...
Ma Haiyan - - 2013
Despite recent advances in therapeutic and diagnostic approaches, coronary artery disease (CAD) and its related cardiac disorders represent the most common cause of death in the United States. Nuclear myocardial perfusion imaging (MPI) technologies play a pivotal role in the diagnosis and treatment design for CAD. Recently, in order to ...
Gupta Prabha Nini - - 2013
We present a patient who had a wide QRS tachycardia; it was initially difficult to determine whether it was superventricular tachycardia (SVT) or ventricular tachycardia (VT). By some criteria (sinus capture beats, pseudo-δ waves and wide QRS) the patient's ECG was suggestive of VT of epicardial origin. On the coronary ...
Zasada Wojciech - - 2013
We present the case of a 57-year-old male patient with a diagnosis of non-ST-segment elevation myocardial infarction. Taking into consideration the clinical presentation and angiographic findings, the patient was qualified for emergent percutaneous coronary intervention with aspiration thrombectomy and bioresorbable vascular scaffold implantation (BVS; Absorb, Abbott), with good angiographic result.
Sayed Ali Sheikh Md - - 2013
Rapid and correct diagnosis of acute myocardial infarction (AMI) plays a crucial role in saving patients' life. Although some biomarkers (such as cardiac troponin and creatine kinase) are available for AMI diagnosis so far, there is still a clinical need for novel biomarkers, which can reliably rule in or rule ...
Vyas Chirayu - - 2012
We report a patient who presented with takotsubo cardiomyopathy but was misdiagnosed as an anterior wall ST elevation myocardial infarction (AWMI). We illustrate how misdiagnosis led to mismanagement by initiating intravenous inotropic agents that led to further hemodynamic compromise. Subsequent withdrawal of the inotropic agents and simultaneous administration of oral ...
Lee Ting-Wei - - 2012
Objective: To present an atypical manifestation in a patient with pheochromocytoma. Clinical Presentation and Intervention: A 48-year-old man presented with chest pain, fever and leukocytosis. Elevated cardiac biomarkers and diffuse ST-T abnormalities on electrocardiography suggested myocardial infarction. However, coronary angiography showed normal coronary arteries. Abdominal computed tomography revealed a left ...
Hongo Hiroki - - 2012
A 61-year-old man who experienced a sudden onset of unstable gait followed by nuchal pain was admitted to our department. The neurologic examination revealed right-sided limb ataxia, right partial ptosis, and decreased sensation to 50% of the normal side to pinprick and temperature stimuli on the left side below the ...
Lackner Karl J - - 2012
Abstract In the case of suspected acute coronary syndrome and myocardial infarction positive diagnosis or exclusion strongly depend on the use of biomarkers and in particular cardiac troponins (cTn). Especially in the early phase of myocardial infarction the sensitivity of cTn assays has been unsatisfactory. This has led to the ...
Pollak Peter - - 2012
The 12-lead electrocardiogram (ECG) remains the cornerstone of prompt diagnosis of STEMI; Furthermore, the 12-lead ECG provides the primary indication for emergent reperfuison therapy in the STEMI patient. In certain cases, a patient's ECG can resemble STEMI yet manifest ST-segment elevation from a non-coronary-based syndrome; these entities are termed the ...
Benjamin Mina M - - 2012
Left ventricular noncompaction (LVNC) is a rare disorder in which the left ventricular endocardial surface is not appropriately flattened and is heavily trabeculated. Patients with this condition can be affected by stroke from emboli that originate from these recesses. We present a patient with LVNC who was originally misdiagnosed as ...
Schillaci Giuseppe - - 2012
ECG remains the first line method for detection of left ventricular hypertrophy (LVH) in patients with hypertension. ECG diagnosis of LVH predicts a several-fold increase in age- and risk factor-adjusted cardiovascular morbidity and mortality in asymptomatic patients with essential hypertension. When compared with traditional ECG methods, Cornell voltage product and ...
Lawner Benjamin J - - 2012
Diagnosis of ST-segment elevation myocardial infarction has long been considered time sensitive. Several other electrocardiogram abnormalities, sometimes referred to as "STEMI-equivalents", should also alert the clinician to conditions similarly requiring aggressive intervention. The de Winter/ST/T complex, ST-segment elevation in lead aVR, Wellens' phenomenon, posterior wall myocardial infarction, and pathologic ST ...
Papanicolaou Kyriakos N KN Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, - - 2012
At birth, there is a switch from placental to pulmonary circulation and the heart commences its aerobic metabolism. In cardiac myocytes, this transition is marked by increased mitochondrial biogenesis and remodeling of the intracellular architecture. The mechanisms governing the formation of new mitochondria and their expansion within myocytes remain largely ...
Xie Linglin L Department of Pediatrics, The University of Chicago, Chicago, IL 60637, - - 2012
The developmental mechanisms underlying human congenital heart disease (CHD) are poorly understood. Atrial septal defects (ASDs) can result from haploinsufficiency of cardiogenic transcription factors including TBX5. We demonstrated that Tbx5 is required in the second heart field (SHF) for atrial septation in mice. Conditional Tbx5 haploinsufficiency in the SHF but not ...
Tao Ge - - 2012
Collagen XIV is a fibril-associated collagen with an interrupted triple helix (FACIT). Previous studies have shown that this collagen type regulates early stages of fibrillogenesis in connective tissues of high mechanical demand. Mice null for Collagen XIV are viable, however formation of the interstitial collagen network is defective in tendons ...
Hinits Yaniv Y Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, UK. - - 2012
Mef2 transcription factors have been strongly linked with early heart development. D-mef2 is required for heart formation in Drosophila, but whether Mef2 is essential for vertebrate cardiomyocyte (CM) differentiation is unclear. In mice, although Mef2c is expressed in all CMs, targeted deletion of Mef2c causes lethal loss of second heart ...
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