Search Results
Results 251 - 300 of 1027
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Waring W Stephen - - 2007
BACKGROUND: Monoamine oxidase inhibitors (MAOIs) are uncommonly used due to their high frequency of adverse effects, including tachycardia and hypertension. Recently, there has been renewed interest in the role of this class of drugs in treating a variety of psychiatric disorders. The clinical features of MAOI overdose are poorly characterised. ...
Hosch Waldemar - - 2007
OBJECTIVE: This study evaluates if MR-relaxometry of myocardial tissue reveals significant differences in cardiac amyloidosis (CA) compared with patients with systemic amyloidosis but without cardiac involvement (NCA) and a healthy control group. Therefore, we measured T1 and T2 relaxation times (RT) of the left ventricular myocardium with magnetic resonance imaging ...
Hiemann Nicola E - - 2007
BACKGROUND: Epicardial vasculopathy has been shown to be associated with poor outcome after heart transplantation. We demonstrate that histologically proven stenotic microvasculopathy is a novel prognostic factor for long-term survival. METHODS AND RESULTS: In 9713 biopsies harvested within the first posttransplantation year from 873 patients (83% male; mean age, 49.1+/-0.6 ...
Aktas Yilmaz Banu - - 2008
Secondary amyloidosis (AA amyloidosis) has rarely been described in patients with systemic lupus erythematosus (SLE). We, herein, present a 56-year-old female patient, who developed AA amyloidosis following a 22-year history of SLE. She developed severe mitral regurgitation complicated with chordae tendinea rupture that led to acute congestive heart failure and ...
Kontani Makoto - - 2007
An 81-year-old man was referred to our hospital with exertional dyspnea following cold-like symptoms. Electrocardiography revealed ST elevation and positive T wave in leads I, II, aVL, aVF, and V2-V6. The diagnosis was acute myocarditis complicating heart failure. He was conservatively managed. On hospital day 8, brain infarction developed and ...
Daliri Armand - - 2007
Percutaneous computed tomographic (CT) fluoroscopy-guided biopsy was performed to evaluate an intracardiac tumor located within the left atrium of a 72-year-old woman. Postinterventional follow-up was unproblematic and free of complications. Histopathologic examination revealed a high-grade cardiac sarcoma, and the patient underwent consecutive resection and radiation therapy. In general, percutaneous puncture ...
Cross Brian - - 2007
Cardiac sarcoidosis is most often clinically silent. When symptomatic, it commonly involves the conduction system. This inflammatory and infiltrative process may be manifest as conduction delays and/or important ventricular ectopy. More diffuse myocardial infiltration may result in congestive heart failure (CHF). This case report illustrates how a more focal infiltrative ...
Ellis Christopher R - - 2007
Myocarditis represents a heterogeneous final common pathway for myocardial inflammation of diverse etiologies and accounts for up to one-third of cases of dilated cardiomyopathy. The pathophysiology of viral myocarditis can be disaggregated into the effects of direct viral mediated injury, triggered acute and chronic autoimmune responses, and subsequent adverse remodeling. ...
Krombach Gabriele A - - 2007
In cardiac amyloidosis an interstitial deposition of amyloid fibrils causes concentric thickening of the atrial and ventricular walls. We describe the results of tissue characterization of the myocardium by T1 quantification and MRI findings in a patient with cardiac amyloidosis. The T1 time of the myocardium was elevated compared to ...
Saegusa Seiichiro - - 2007
We examined the effects of the angiotensin II receptor type 1 blocker candesartan on myocarditis injury in a murine model of acute myocarditis. We hypothesized that candesartan improves cardiac damage by inducing cardiac expression of adiponectin. We examined changes in heart failure caused by myocarditis in mice by candesartan based ...
Hakeem Abdul - - 2007
A young man with a strong family history of myocardial infarction with sudden death presented with chest pain and was found to have positive cardiac biomarkers and echocardiographic evidence of inferolateral wall hypokinesia. He was managed as an acute coronary syndrome and underwent a thorough ischemic work-up which was negative. ...
Trybus J - - 2007
Uterine infarctions have not been reported in domestic animals, and there are few reports in the human medical literature. In a retrospective study, uterine infarctions were identified in 9 of 323 (2.8%) female cynomolgus monkeys (Macaca fascicularis) necropsied over a 13-year period. The infarctions were grossly visible, after fixation, on ...
Di Bella Gianluca - - 2008
Usually, during acute phase of focal myocarditis, edema is located in the epicardial layer of the ventricular wall and it can't be associated with clear evidence of wall motion abnormalities on echocardiography. Among many cardiac imaging techniques, only cardiac magnetic resonance (CMR) and computer tomography permit a direct detection of ...
Garibaldi Brian - - 2007
Cardiac amyloidosis can result from any of the systemic amyloidoses. The disease is often characterized by a restrictive cardiomyopathy although the particular signs and symptoms depend in part on the underlying cause. In addition to managing the symptoms of heart failure, treatment options vary depending on the etiology of amyloid ...
Auriti Antonio - - 2007
Biopsy of the heart has become a widely applied technique in circumstances such as detection of a transplant reject or histological diagnosis of masses. Biopsy is usually performed in the catheter laboratory (cath-lab) under fluoroscopic guidance. Echocardiography guidance is employed but as 'ancillary' comforting support to the cath-lab operator and ...
Avella Andrea - - 2007
A positive endomyocardial biopsy (EMB) is a major diagnostic criterion for arrhythmogenic right ventricular cardiomyopathy (ARVC). Nevertheless, its sensitivity is low due to the focal nature of the disease. Moreover, myocardial samples are usually taken from the uncommonly involved interventricular septum to minimize the risk of perforation. In this report, ...
Pawlak Agnieszka - - 2007
BACKGROUND: Desmin plays one of the key roles in cardiomyocytes. The protein protects the integration of the cell and has the following actions: mechanical, structural and regulatory. Observed abnormalities of its activity have been associated with worsening of heart failure (HF). AIM: Evaluation of desmin activity detected with immunohistochemical (IHC) ...
Tandri Harikrishna - - 2007
A 46-year-old white woman presented to the emergency department with hemodynamically stable sustained ventricular tachycardia (VT). She was chemically cardioverted with lidocaine. Her electrocardiogram, showing sinus rhythm, was unremarkable, and serial cardiac enzyme tests excluded myocardial infarction. A signal-averaged electrocardiogram was abnormal, with a filtered QRS duration of 187 milliseconds. ...
Obata Hiroaki - - 2007
Myocarditis is an acute inflammatory disease of the myocardium for which there is currently no specific therapy. We investigated the therapeutic potential of C-type natriuretic peptide (CNP) in acute experimental autoimmune myocarditis. One week after injection of porcine myosin into male Lewis rats, CNP (0.05 microg/kg/min) was continuously administered for ...
Brown Morgan L - - 2007
Cardiac sarcoid is a rare and frequently fatal disease. We report a case of isolated cardiac sarcoid diagnosed during elective cardiac surgery. Although this patient presented with a history that was consistent with sarcoid heart disease, diagnosis is challenging when there is no other organ involvement with sarcoid. The patient ...
Mikami Yoko - - 2007
Cardiac amyloidosis is generally a progressive disease with a poor prognosis, so early diagnosis and appropriate treatments are important. Although cardiac amyloidosis can be diagnosed definitively by endomyocardial biopsy, non-invasive methods of diagnosis are desired because of a great risk in biopsy. In ECG-gated enhanced multislice computed tomography, not only ...
Talerico, Cassandra
Background: This project examined JAK-STAT pathway activation in two mouse models of cardiac hypertrophy: autoimmune myocarditis and pressure overload (PO). Methods: Myocarditis was induced with cardiac myosin; PO was induced by transverse aortic constriction. STAT1, 3, and 5 binding was assessed by gel shift. STATs, JAKs, SERCA2A, and calsequestrin (CSQ) ...
Kato Shigeru - - 2007
A 45-year-old man developed fulminant myocarditis for which ventricular assist devices (intra-aortic balloon pumping and percutaneous cardiopulmonary support) were required for hemodynamic support. Echocardiography showed left ventricular akinesis and, since no improvement was noted on the following day, immunoglobulin (70 g/day for 2 days) was added to the therapy. The ...
Eshaghian Shervin - - 2007
When amyloidosis affects the heart, a devastating and progressive process can lead to congestive heart failure, arrhythmias, conduction abnormalities, angina, and death. The signs and symptoms of cardiac amyloidosis are generally dominated by diastolic heart failure resulting from restrictive cardiomyopathy. Amyloid infiltration of the heart initially causes mild diastolic dysfunction, ...
Hiramitsu Shinya - - 2007
Transient left ventricular (LV) wall thickening is observed in patients with acute lymphocytic myocarditis. The present study was undertaken to clarify the significance of transient LV wall thickening in patients with this disease. The subjects comprised 25 patients with acute lymphocytic myocarditis. Echocardiography was used to measure the thickness of ...
Yagi Shusuke - - 2007
AL amyloidosis is a disease in which immunoglobulin L chain is deposited in multiple organs, and the prognosis of cardiac amyloidosis is extremely poor. Although several treatments based on that for multiple myeloma, have been performed, there is no clear evidence that cardiac function is improved. We report a case ...
Laky D - - 2007
Hibernating myocardium represent a prolonged but potentially reversible myocardial contractile dysfunction, an incomplete adaptation caused by chronic myocardial ischemia and persisting at least until blood flow restored. The purpose of this study was to investigate the morphological changes and weather relations exist among function, metabolism and structure in left ventricular ...
Mamas Mamas A - - 2007
A case of influenza A myopericarditis is presented in a patient with cardiac tamponade and immunomediated cardiac failure. Myocarditis is a rare and potentially lethal complication of infection with influenza A, and may manifest with a wide spectrum of cardiac involvement, from mild myocarditis to cardiogenic shock. Even with full ...
Hung Ming-Yow - - 2007
This study was designed to evaluate the role and effectiveness of gallium 67 imaging in the diagnosis of acute myocarditis that mimics acute myocardial infarction. Of 315 consecutive acute myocardial infarction patients admitted to our institution over a 4-year period, 5 (2 men, 3 women) were suspected of having acute ...
Han Juyup - - 2006
Endomyocardial biopsy (EMBx) is a useful tool for diagnosing various cardiac pathologies. However, the routine use of EMBx has not gained widespread acceptance due to the possible complications related to the EMBx. Thus, not much information is available on the complications related to the EMBx. We prospectively evaluated 90 consecutive ...
Al Ali Abdullah M - - 2006
Although the etiology of eosinophilic myocarditis (EM) is not always apparent, several causes are identified, including hypersensitivity to a drug or substance, with the heart as the target organ. However, symptoms and signs of hypersensitivity are not found in all patients. EM can lead to progressive myocardial damage with destruction ...
Angelini Annalisa - - 2007
Hibernating myocardium (HM) is viable but dysfunctional myocardium which can recover following revascularization. Myocyte necrosis is virtually absent in HM; however, cellular loss may take place by apoptosis, although this is controversial. To assess the presence of apoptosis and its relevance in HM. During coronary artery by-pass surgery (CABG), 21 ...
Bahlmann Edda - - 2007
The phenomenon of transient apical ballooning is a rare underlying cause of severe left ventricular dysfunction and has been described as Tako-Tsubo-like cardiomyopathy. Acute myocarditis has been reported to masquerade as acute myocardial infarction or vice versa and is considered as differential diagnosis in this phenomenon. We present here a ...
Cheng Y-K - - 2006
BACKGROUND: Nasal polyposis (NP) is a chronic inflammatory disease of upper airway with unknown etiology. NP is frequently associated with asthma; the interaction between these comorbidities remains interesting. Oxidative stress has been implicated in the pathophysiology of NP and asthma. The aim of this study is to investigate the significance ...
Cooper Leslie T LT - - 2006
Acute or fulminant nonischemic, dilated cardiomyopathy (DCM) is an uncommon cause for heart failure with a highly variable prognosis that is in part dependent on histopathology and in part on clinical presentation. Once common causes of acute DCM are excluded using standard clinical tests, the specific inflammatory and infectious causes ...
Cheng Adrian S H - - 2006
Cardiac involvement is a significant cause of morbidity and mortality in patients with amyloidosis. A 73-year old Caucasian woman was admitted to a hospital with increasing dyspnoea. Examination revealed a large left-sided pleural effusion, gross peripheral oedema and a pan-systolic murmur. The electrocardiogram showed low voltage QRS complexes with lateral ...
Mahrholdt Heiko - - 2006
BACKGROUND: Enteroviruses and adenoviruses have been considered the most common causes of viral myocarditis, but parvovirus B19 (PVB19) and human herpesvirus 6 (HHV6) are increasingly found in endomyocardial biopsy samples. METHODS AND RESULTS: Consequently, our aim was to evaluate the prevalence and clinical presentation of cardiac PVB19 and/or HHV6 infection ...
Tincani A - - 2006
Cardiac involvement is one of the main complications substantially contributing to the morbidity and mortality of patients suffering from systemic autoimmune diseases. All the anatomical heart structures can be affected, and multiple pathogenic mechanisms have been reported. Non-organ-specific autoantibodies have been implicated in immune complex formation and deposition as the ...
Murphy Ross T - - 2006
Cardiac amyloidosis typically presents with diastolic heart failure, but asymmetrical septal hypertrophy with outflow tract obstruction has been described. We illustrate the case of a 71-year-old woman with biopsy-proven cardiac amyloidosis and severe medical comorbidities with refractory severe heart failure who had asymmetric septal hypertrophy, systolic anterior motion (SAM) of ...
Maisch B - - 2006
Invasive diagnostic and therapeutic techniques are indispensable for the diagnosis and interventional treatment of coronary artery disease, valvular involvement and, in particular, if the specific components of the inflammatory or degenerative processes in rheumatic disease are to be identified in the different components of the heart. Although impairment of cardiac ...
Doyle Amy - - 2006
Rocky Mountain Spotted Fever (RMSF), caused by Rickettia rickettsii, is a serious tickborne illness that is endemic in the southeastern United States. Although it is most commonly known as a cause of fever and rash, it can have systemic manifestations. The myocardium may rarely be involved, with symptoms that can ...
Mizuno Reiko - - 2007
BACKGROUND: Echocardiographic modalities have challenged the myocardial tissue characterization, but this reliability has not reached to the clinical use. This study investigated whether combined tissue harmonic imaging (THI) and integrated backscatter analysis (IB) provide the reliable and quantitative information about myocardial fibrosis in idiopathic dilated cardiomyopathy (DCM) in comparison with ...
Brahmi Nozha - - 2006
We present 2 cases of myocardial damage induced by Paraphenylenediamine (PPD) poisoning in young patients without any history of cardiovascular disease. ECG findings revealed the presence of localized ST segment elevation in precordial leads (V1-V4) in the first case and (V3-V6) in the second associated to an increase of the ...
Hiramitsu Shinya - - 2006
Most patients with acute myocarditis manifest particular clinical signs and symptoms, including marked cardiac failure and/or a high degree of atrioventricular block on admission. However, a 78-year-old man did not have symptoms and was hospitalized as a result of abnormalities observed on an incidentally obtained electrocardiogram (ECG). Several days later, ...
Heymans Stephane - - 2006
BACKGROUND: Acute viral myocarditis is an important cause of cardiac failure in young adults for which there is no effective treatment apart from general heart failure therapy. The present study tested the hypothesis that increased expression of the proteinases urokinase-type plasminogen activator (uPA) and matrix metalloproteinases (MMPs) is implicated in ...
Kiuchi Shintaro - - 2007
We report a case in which late gadolinium enhancement (LGE) and 67-Ga scintigraphy were useful for the diagnosis of cardiac sarcoidosis and for the evaluation of the disease activity. The patient was a 60-year-old woman who had been diagnosed as having eye sarcoidosis when she was 48. Two years previously ...
Garcia-Pavia Pablo - - 2006
Cardiac Magnetic Resonance (CMR) imaging has recently become a very useful tool in the diagnosis of myocarditis. We describe a patient in whom acute myocarditis was presented as an acute myocardial infarction and had an atypical course with rapid normalization of ECG abnormalities. In this case CMR imaging was essential ...
Butany Jagdish - - 2006
BACKGROUND: Primary cardiac sarcoidosis (CS) is rare, and concomitant involvement of the coronary arteries is rarer still. Successful diagnosis of this disease is difficult due to its nonspecific symptoms which mimic those of idiopathic dilated cardiomyopathy (IDCM). METHODS AND RESULTS: We describe a 47-year-old Caucasian male who underwent orthotopic heart ...
van Haelst Paul L - - 2006
Giant cell myocarditis (GCM) is a serious condition that warrants immediate diagnosis and treatment. It often presents as rapidly progressive heart failure and/or malignant ventricular arrhythmias. Here, we describe a 34-year-old patient with myasthenia gravis who presented with GCM 2 weeks after resection of a thymoma. A cardiac biopsy confirming ...
Edibam Cyrus - - 2006
This case presentation describes the very rare condition of isolated atrial amyloidosis and it's associated complications. A 53-year-old male presented to hospital in severe pulmonary edema secondary to spontaneous intramural left atrial hemorrhage and subsequent wall dissection causing acute "pre-mitral valve" obstruction. The patient was subsequently found to have AL ...
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