Search Results
Results 1 - 50 of 745
1 2 3 4 5 6 7 8 9 10 >
Kumar Prabhat - - 2015
Implantable cardioverter-defibrillator (ICDs), cardiac resynchronization (CRT) and combination (CRT-D) therapy have become an integral part of the management of patients with heart failure with reduced ejection fraction (HFrEF). ICDs treat ventricular arrhythmia and CRTs improve left ventricular systolic function by resynchronizing ventricular contraction. Device therapies (ICD, CRT-D), have been shown ...
Stulc Tomáš T 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, U Nemocnice 1, 128 21, Prague, Czech Republic, - - 2014
Ivabradine is generally considered to be a safe drug with well-established and substantial benefits. Nevertheless, recently published results from the SIGNIFY trial suggest that ivabradine has rather inconsistent effects on cardiovascular outcomes. In addition, careful examination of all available data from ivabradine trials reveals signals of harm that have not ...
Spiro Jon J Department of Cardiology, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, - - 2014
In an effort to improve outcomes in percutaneous coronary intervention (PCI), percutaneous ventricular assist devices (PVADs) have been investigated in (1) high-risk PCI, (2) acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) and (3) in AMI without CS. PCI has become an increasing complex due to an ageing population ...
Zhuang Jianhui J aDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China bCardiology Division, Spedali Civili and University of Brescia, Brescia, Italy cDepartment of Geriatrics, the 113th Hospital of Chinese People's Liberation Army, Ningbo, China dSection of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy eDepartment of Blood Transfusion, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China *Jianhui Zhuang and Pompilio Faggiano contributed equally to the writing of the - - 2014
An increasing number of clinical studies have explored the possibility of using tumor biomarker carbohydrate antigen 125 (CA 125) in the management of patients with heart failure. This systematic review and meta-analysis was performed to comprehensively summarize the available evidence and evaluate the applicability of CA 125 in heart failure. ...
Adachi Toru T Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, - - 2014
-Septal atrial tachycardia (AT) can occur in patients without structural heart disease and in patients with prior catheter ablation of atrial fibrillation. We aimed to assess septal AT that occurs after open-heart surgery. -This study comprised 20 consecutive patients undergoing catheter ablation of macroreentrant AT after open-heart surgery. Relevance to ...
Raje Vikram P VP Department of Internal Medicine, Division of Cardiovascular Disease. Virginia Commonwealth University†. Hunter Holmes McGuire Veterans Medical - - 2014
Dobutamine is a rare and unrecognized cause of eosinophilic myocarditis. It is even more unique for it to cause significant clinical deterioration. Patients with end stage cardiomyopathy have very little cardiac reserve and dobutamine induced myocarditis may cause enough harm to require urgent mechanical circulatory support. We describe a man ...
Bruns Danielle R DR University of Colorado - - 2014
Right ventricular (RV) function is a key determinant of survival in patients with both right and left ventricular failure, yet the mechanisms of RV failure are poorly understood. Recent studies suggest cardiac metabolism is altered in RV failure in pulmonary hypertension (PH). Accordingly, we assessed mitochondrial content, dynamics and function ...
Hasun Matthias M 2. Medizinische Abteilung, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Vienna, - - 2014
Atrial fibrillation (AF) is by far the most frequent heart rhythm disorder and is associated with a significantly increased risk of stroke, heart failure and death. Despite improvements in prevention and treatment, the prognosis has not changed significantly. To use new and promising pharmacological and interventional concepts for thromboembolic prophylaxis ...
Malik Rabiya R Cardiovascular Center, Tufts Medical Center, Tufts University School of Medicine, Boston, - - 2014
Ectopia cordis, defined as partial or complete displacement of the heart outside of the thoracic cavity, is a rare congenital malformation. If not surgically corrected during the early years of life, ectopia cordis can prove to be a fatal abnormality. However, due to the presence of multiple intracardiac and extracardiac ...
Dipoce Jason J Staff Radiologist Hadassah Medical Center Jerusalem, - - 2014
This article will familiarize the reader with several different cardiac devices including pacemakers and implantable cardioverter-defibrillators (ICDs), intra-aortic balloon pump, ventricular assist devices, valve replacements and repairs, shunt occluding devices and passive constraint devices. Many cardiac devices are routinely encountered in clinical practice. Other devices are in the early stages ...
Castaño Adam A Center for Advanced Cardiac Care, Columbia College of Physicians and Surgeons, New York City, NY, USA, - - 2014
Transthyretin-cardiac amyloidoses (ATTR-CA) are an underdiagnosed but increasingly recognized cause of heart failure. Extracellular deposition of fibrillary proteins into tissues due to a variety of inherited transthyretin mutations in ATTRm or due to advanced age in ATTRwt eventually leads to organ failure. In the heart, amyloid deposition causes diastolic dysfunction, ...
Moses-Arms Ashley A Department of Biological and Environmental Sciences, Texas A&M University-Commerce, Commerce, TX, 75429-3011, - - 2014
Heart disease is the number one killer in the USA, making cardiogenesis and its related pathways a relevant area of study for improving health and life expectancy. The Mexican salamander (axolotl), Ambystoma mexicanum, provides an excellent vertebrate animal model for studying myofibrillogenesis due to its naturally occurring cardiac nonfunction mutation. ...
Reddy Sushma S Department of Pediatrics, Stanford University, Stanford, CA, - - 2014
BackgroundAdrenergic receptor (ADR) genotypes are associated with heart failure (HF) and β-blocker response in adults. We assessed the influence of ADR genotypes in children with dilated cardiomyopathy (DCM).Methods91 children with advanced DCM and 44 with stable DCM were genotyped for 3 ADR genotypes associated with HF risk in adults: α2cdel322-325, ...
Stacey R Brandon RB Department of Internal Medicine Section on Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA, - - 2014
Left ventricular (LV) noncompaction cardiomyopathy (LVNC) is a form of cardiomyopathy in which trabeculations fail to "compact" with the left ventricular endocardium during fetal cardiac development and is classically associated with subsequent impairment of LV function, significant mortality, ventricular dysrhythmias, and embolic phenomena. As awareness and medical imaging quality have ...
Pfeffer Marc A MA Cardiovascular Division, Brigham and Women 's Hospital, 75 Francis Street, Boston, Massachusetts 02115 - - 2014
-Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) patients with heart failure and preserved left ventricular ejection fraction assigned to spironolactone did not achieve a significant reduction in the primary composite outcome (time to cardiovascular death, aborted cardiac arrest, or hospitalization for management of heart failure) ...
Packer Milton M Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX - - 2014
-Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs on the risk of clinical deterioration in surviving patients. -We compared the angiotensin-neprilysin inhibitor LCZ696 (400 mg daily) with ...
Germer Carina M CM Centro de Engenharia Biomédica, UNICAMP, R. Alexander Fleming 163, Cid. Universitária Zeferino Vaz, Campinas, SP, 13083-881, - - 2014
The electrocardiogram (ECG) is the simplest and most effective non-invasive method to assess the electrical activity of the heart and to obtain information on the heart rate (HR) and rhythm. Because information on the HR of very small reptiles (body mass <10 g) is still scarce in the literature, in the ...
Qiu Qiong Q Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yanjiang Road, Guangzhou, 510120, - - 2014
Left ventricular noncompaction (LVNC) is a rare cardiomyopathy with high incidence of heart failure (HF). It is unclear whether LVNC patients with desynchronized HF would benefit from cardiac resynchronization therapy (CRT). In order to evaluate the effect of CRT on LVNC, this study explored left ventricular (LV) remodeling and mechanical ...
Grotenhuis Heynric B HB Labatt Family Heart Center, Hospital for Sick Children, The University of Toronto, Toronto, Ontario, - - 2014
Echocardiography is the first-line diagnostic technique in patients with congenital heart disease. Recent developments include further standardization of pediatric and congenital echocardiography with general-specific and lesion-specific guidelines. New research focuses on clinical validation of echocardiographic quantitative techniques for assessing right ventricular and single ventricular function. Recent guidelines include standardization of ...
- - 2014
Essential facts Each year, 175,000 people in the UK experience a myocardial infarction, or heart attack. This happens when the heart muscle is starved of oxygen-rich blood, causing damage to the muscle. Most heart attacks are caused by coronary heart disease (CHD), when the coronary arteries become narrowed by a ...
Chatterjee Neal N Massachusetts General Hospital, Harvard Medical School, Boston, - - 2014
Heart failure with preserved left ventricular (LV) ejection fraction (HFpEF) represents approximately half of patients with heart failure and confers similar morbidity and mortality as HF with reduced left ventricular ejection fraction (HFrEF).(1) HFpEF has been characterized by abnormal LV diastolic function, abnormal LV-central vascular coupling, impaired systolic reserve and ...
Peng Tao T Department of Nephrology, Shandong University Qilu Hospital, Jinan 250012, - - 2014
Background/Aims: To investigate the role of endothelial dysfunction on left ventricular remodeling in patients with chronic kidney disease and to evaluate the correlation between endothelial dysfunction and left ventricular remodeling. Methods: Seventy-three patients with chronic kidney disease as study-group and thirty healthy volunteers as control-group were enrolled in the present ...
Harring Gesa G University Heart Center Hamburg, Department of Pediatric Cardiology, University Hospital Hamburg- Eppendorf, Martinistrasse 52, 20246 Hamburg, - - 2014
Pentalogy of Cantrell (P.o.C.) is a rare congenital midline defect. We present a case and its treatment of P.o.C. with complete ectopia cordis and congenital heart disease. Postnatally the congenital heart defect was surgically corrected and the ectopic heart was covered by musculous mobilized flap. Due to cephalic orientation of ...
Seeger Joost Ph JP Department of Physiology, Radboud University Medical Centre, Nijmegen, The Netherlands Department of Pharmacology-Toxicology, Radboud University Medical Centre, Nijmegen, The - - 2014
Reperfusion is mandatory after ischaemia, but it also triggers ischaemia-reperfusion (IR)-injury. It is currently unknown whether heart failure alters the magnitude of IR-injury. Ischaemic preconditioning can limit IR-injury. Since ischaemic preconditioning is typically applied in subjects at risk for cardiovascular complications, it is of clinical importance to understand its efficacy ...
Halbach Marcel M Department of Internal Medicine III, Heart Center, University of Cologne, Kerpener Str. 62, 50937 Cologne, - - 2014
Sympathovagal imbalance plays a major role in the progression of heart failure with reduced ejection fraction. Baroreflex activation therapy (BAT) by electrical stimulation of baroreceptors located at the carotid sinus can reduce sympathetic and increase parasympathetic tone. This review provides an overview on the concept of BAT in heart failure ...
Hu Jing J Department of Pharmacy, General Hospital of Lanzhou Command, PLA, Lanzhou, 730050, China, - - 2014
Apigenin (Api), a mainly bioactive component of Apium graveolens L. var. dulce DC. (a traditional Chinese medicinal herb), possesses a wide range of biological activities, including antioxidant effects. It also has been shown to associate with lower prevalence of cardiovascular diseases, but its mechanisms of action remain unclear. The aim ...
Stienen G J M GJ Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands, - - 2014
Heart failure is a multi-factorial progressive disease in which eventually the contractile performance of the heart is insufficient to meet the demands of the body, even at rest. A distinction can be made on the basis of the cause of the disease in genetic and acquired heart failure and at ...
Gerdes A Martin AM New York College of Osteopathic Medicine at New York Institute of Technology - - 2014
The link between low thyroid hormone (TH) function and heart failure (HF) is reviewed. The idea that TH dysfunction may contribute to diseases leading to HF has been discussed for over 60 years. A growing body of evidence from animal and human studies, particularly in recent years, suggests that TH ...
Imamura Teruhiko T Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, University of - - 2014
Background:Predicting the occurrence of aortic insufficiency (AI) during left ventricular assist device (LVAD) support has remained unsolved.Methods and Results:We enrolled 52 patients who had received continuous flow LVAD (14 axial and 38 centrifugal pumps) and who been followed for ≥6 months between Jun 2006 and Dec 2013. Native aortic valve (AV) opening ...
Fresiello Libera L Institute of Clinical Physiology, Section of Rome, National Research Council, Rome, - - 2014
The current use of left ventricular assist devices (LVADs) as destination therapy is associated with the clinical need of monitoring patient-pump interaction. To this aim, the present work investigated the possibility of getting useful information about the status of the assisted left ventricle using electrocardiographic (ECG) data. A total of ...
Tsioufis Costas C aFirst Cardiology Clinic, University of Athens, Hippocration Hospital, Athens, Greece bVeterans Affairs and Georgetown University Medical Centers, Washington, District of Columbia cSt. Jude Medical, Inc., Irvine, California, USA dClinica Medica, University of Milano-Bicocca, Monza eIstituto di Ricerche a Carattere Scientifico IRCCS Multimedica, Sesto San Giovanni Milan, - - 2014
This EnligHTN I nonrandomized substudy investigated the effect of multielectrode renal denervation (RDN) on cardiac and neurohumoral adaptations. Eighteen patients with true drug-resistant hypertension [age: 56 ± 10 years, 12 men, BMI: 33.6 ± 5.4 kg/m, office blood pressure (BP) by automatic device (Omron): 182 ± 19/97 ± 18 mmHg and ambulatory BP (Spacelabs): 153 ± 16/87 ± 15 mmHg receiving 4.5 antihypertensive drugs/day] and ...
Rodríguez-Sinovas Antonio A Laboratorio de Cardiología Experimental, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain antonio.rodriguez.sinovas@vhir.org - - 2014
Microtubules play a major role in transmitting mechanical forces within the myocardium, and in maintaining organelle function. However, this intracellular network is disrupted during myocardial ischemia/reperfusion. We assessed the effects of prevention of microtubule disruption with paclitaxel on ischemia/reperfusion injury in isolated rat cardiomyocytes and hearts. Isolated rat cardiomyocytes were ...
Saito Shunsuke S Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan, - - 2014
Myocardial recovery occurs in a small cohort of patients receiving left ventricular assist device (LVAD) support, but identification of candidates for device removal remains challenging. We hypothesized that hemodynamic evaluation using echocardiography and right heart catheter during temporary suspension of LVAD support (LVAD-off test) can assess cardiac recovery to predict ...
Cheng Min M State Key Laboratory of Cardiovascular Disease, Department of Evidence Based Medicine, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beili Shi Road 167, Beijing, - - 2014
The prognostic significance of atrial fibrillation (AF) in patients with heart failure remains inconclusive. To perform a meta-analysis of the published data to study the prognostic significance of AF in heart failure patients and to determine whether this relates to the presence of preserved or reduced left ventricular systolic function. ...
Lankford Harvey V HV 1 Richmond, - - 2014
Abstract Lankford, Harvey V, Erik R Swenson. Dilated hearts at high altitude: Words from on high. High Alt Med Biol 15:000-000, 2014.-From the time of the turn of the twentieth century, dilated hearts and presumed cardiac fatigue in expeditionary climbers and scientists have been the subject of much commentary in ...
Gigliotti Osvaldo S OS Seton Heart Institute, Austin, - - 2014
The rationale to perform left ventriculography at the time of cardiac catheterization has been little studied. The technique and frequency of use of left ventriculography vary by geographic regions, institutions, and individuals. Despite the recent publication of guidelines and appropriate use criteria for coronary angiography, revascularization, and noninvasive imaging, to ...
Masuda Mio M Department of Metabolism, Endocrinology, Molecular Medicine, and Nephrology, Osaka City University Graduate School of Medicine, Osaka, - - 2014
Background/Aims: β2-Microglobulin (β2-MG) is a major protein component of dialysis-related amyloidosis. In long-term hemodialysis (HD) patients, β2-MG amyloid deposits not only in osteoarticular tissues, but also in systemic tissues, including the heart. The purpose of this study was to investigate the relationship between serum β2-MG concentrations and echocardiographic parameters in ...
Morrison Alex A Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, New York, - - 2014
The regulation of AMPK in the ischemic heart remains incompletely understood. Recent evidence implicates the role of Sestrin2 in the AMPK signaling pathway, and it is hypothesized that Sestrin2 plays an influential role during myocardial ischemia to promote AMPK activation. Sestrin2 protein was found to be expressed in adult cardiomyocytes ...
Kawabata Miko M *Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan Department of Systems Pharmacology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, - - 2014
Sorafenib is associated with adverse cardiac effects, including left ventricular dysfunction. However, the precise mechanism remains unclear. Here, we aimed to establish the genes responsible for this cardiotoxicity using zebrafish and human cardiomyocytes. Fluorescent cardiac imaging using pigmentless zebrafish with green fluorescent protein hearts revealed that the ventricular dimensions of ...
Novo G G Chair and Division of Cardiology, University Hospital P. Giaccone, University of - - 2014
Left ventricular non compaction (LVNC) is a cardiomyopathy due to an arrest of the normal development of myocardium which determines the persistence of foetal myocardium in post--natal life in at least 2/3 of the wall (criterion known as non compacted/ compacted ratio greater than 2). Although in absence of a ...
Koopman Laurens P LP Department of Pediatric Cardiology, ErasmusMC/Sophia Children's Hospital Rotterdam, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands, - - 2014
Obesity prevalence is still on the rise worldwide in both adults and children. In adults, obesity is a significant cardiovascular risk factor associated with increased morbidity and mortality. In children and adolescents this is more controversial, but early changes in cardiovascular function have been observed with possible long-term implications. In ...
Itou Junji J Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota; Stem Cell Institute, University of Minnesota, Minneapolis, - - 2014
The zebrafish heart regenerates after various severe injuries. Common processes of heart regeneration are cardiomyocyte proliferation, activation of epicardial tissue, and neovascularization. In order to further characterize heart regeneration processes, we introduced milder injuries and compared responses to those induced by ventricular apex resection, a widely used injury method. We ...
Spethmann Sebastian S Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany Bundeswehrkrankenhaus Berlin, Abteilung I - Innere Medizin, Berlin, - - 2014
There is a risk for sudden cardiac death and nonfatal arrhythmias for marathon runners. A new telemedical approach to prevent sudden cardiac death could be online electrocardiogram monitoring during endurance sport events, which would allow the emergency services located along the running track to initiate instantaneous therapy. In a first ...
Potse Mark M Center for Computational Medicine in Cardiology, Faculty of Informatics, Università della Svizzera italiana, Via Giuseppe Buffi 13, 6904 Lugano, Switzerland Inria Bordeaux Sud-Ouest, 33405 Talence CEDEX, France - - 2014
Left-ventricular (LV) conduction disturbances are common in heart-failure patients and a left bundle-branch block (LBBB) electrocardiogram (ECG) type is often seen. The precise cause of this pattern is uncertain and is probably variable between patients, ranging from proximal interruption of the left bundle branch to diffuse distal conduction disease in ...
Sedmera David D Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, CZ; Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, - - 2014
Prevalence of cardiac arrhythmias increases gradually with age; however, specific rhythm disturbances can appear even prior to birth and markedly affect fetal development. Relatively little is known about these disorders, chiefly because of their relative rarity and difficulty in diagnosis. In this review, we cover the most common forms found ...
Giovannoni Isabella I Department of Pathology and Molecular Histopathology, Bambino Gesù Children's Hospital, IRCCS, Rome Piazza Sant'Onofrio, 4 00165, Rome, Italy, - - 2014
Generalized arterial calcification of infancy (GACI, OMIM 208000) and pseudoxanthoma elasticum (PXE, OMIM 264800) are rare autosomal-recessive disorders which represent the opposite ends of the same spectrum of pathologies characterized by progressive ectopic calcification and degeneration of elastic fibers at skin, eyes, and cardiovascular level. Patients with GACI suffer from ...
Yilmaz Osman O From the Departments of *Pediatric Cardiology, †Pediatric Infectious Diseases, and ‡Neonatology, Erzurum District Training and Research Hospital, Erzurum, - - 2014
Hypocalcemia is a rare condition that causes dilated cardiomyopathy and can result in heart failure. Patients with hypocalcemia have been reported to recover in 3 to 12 months after calcium and vitamin D replacement therapy as well as treatment of heart failure. A 6-month-old male patient who presented with dyspnea ...
Pettit Mark A MA Emergency Medicine Resident Physician (Pettit), *Department of Emergency Medicine, Christiana Care Health System, Newark, DE; Emergency Medicine Attending Physician, Assistant Professor of Emergency Medicine (Koyfman), †Division of Emergency Medicine, University of Illinois College of Medicine at Peoria, OSF Saint Francis Medical Center, Peoria, IL; and Emergency Medicine Attending Physician, Assistant Professor of Emergency Medicine (Foran), ‡Department of Emergency Medicine, NYU School of Medicine, Bellevue Hospital Center, New York, - - 2014
Myocarditis is an inflammatory disease of the heart that can cause devastating disease in otherwise healthy children. Inciting agents such as viral infection cause direct damage to the myocardial cells, which triggers an inflammatory response that enhances myocardial toxicity and associated morbidity. Severe cases typically present with respiratory distress and ...
Cheung Yiu-Fai YF Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China. Email: - - 2014
This review aims to provide an overview of conventional and novel indices used in clinical and research arenas for evaluation of right ventricular (RV) function in congenital heart diseases with a dual-chambered circulation. Articles cited in this review were selected using PubMed search of publications in English with no date ...
Lin Elaine Y EY Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, - - 2014
Adults with congenital heart disease (CHD) face increased risk for morbidity and mortality with age, but few prognostic models exist. This study aims to assess whether the Heart Failure Survival Score (HFSS), which risk stratifies patients for heart transplantation, predicts outcomes in adults with moderate or complex CHD. This was ...
1 2 3 4 5 6 7 8 9 10 >