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Koopman Laurens P LP Department of Pediatric Cardiology, ErasmusMC/Sophia Children's Hospital Rotterdam, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands, - - 2014
Obesity prevalence is still on the rise worldwide in both adults and children. In adults, obesity is a significant cardiovascular risk factor associated with increased morbidity and mortality. In children and adolescents this is more controversial, but early changes in cardiovascular function have been observed with possible long-term implications. In ...
Rommel John J JJ Division of Cardiology, Department of Medicine, The University of North Carolina at Chapel Hill, 160 Dental Circle, 6th Floor Burnett-Womack Building, Chapel Hill, NC 27599-7075, - - 2014
Left ventricular assist devices (LVADs) are an increasingly common treatment for end-stage systolic heart failure. However, there are limited data on how to best treat patients pharmacologically after LVAD implantation, resulting in uncertainty about which heart failure medications provide the most benefit. Still, some evidence exists that certain medical therapies ...
Vazir Ali A Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust, NIHR Cardiovascular Biomedical Research Unit and Institute of Cardiovascular Medicine and Sciences (ICMS), National Heart and Lung Institute (NHLI), Imperial College London, London, - - 2014
The management of heart failure with preserved ejection fraction (HFpEF) is challenging and requires an accurate diagnosis. Although currently there is no convincing therapy that prolongs survival in patients with HFpEF, treatment of fluid retention and of comorbidities, such as hypertension, myocardial ischemia, and atrial fibrillation, may improve symptoms and ...
D'Elia Emilia E Cardiovascular Department, Papa Giovanni XXIII Hospital, Piazza OMS 1, Bergamo 24127, Italy; University of Pavia, Piazzale Golgi 1, Pavia 27100, - - 2014
Mineralocorticoid receptor antagonists (MRAs) have become mandated therapy in patients with reduced ejection fraction (systolic) heart failure (HF) across all symptom classes. These agents should also be prescribed in the early post-myocardial infarction setting in those with reduced ejection fraction and either HF symptoms or diabetes. This article explores the ...
Shih Chia-Jen CJ School of Medicine, National Yang-Ming University, Taipei, Taiwan & Taipei Veterans General Hospital, Yuanshan Branch, Yilan, - - 2014
-Substantial infective endocarditis (IE)-related morbidity and mortality may occur even after successful treatment. However, no previous study has explored long-term hard endpoints (i.e., stroke, myocardial infarction, heart failure, cardiovascular death) in addition to all-cause mortality in IE survivors. -A nationwide population-based cohort study was conducted among IE survivors identified using ...
Monfredi Oliver O From the Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom (O.M., H.S., M.N., M.R.B.); Laboratory of Cardiovascular Science, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD (O.M., A.E.L., V.A.M., E.G.L.); K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway (A.-B.J., U.W.); Laboratory of Biomedical Sciences and Information Management, National Cerebral and Cardiovascular Center, Osaka, Japan (S.I.); and Biological Physics Group, University of Manchester, Manchester, United Kingdom (R.W., H.Z.). - - 2014
Heart rate (HR) variability (HRV; beat-to-beat changes in the R-wave to R-wave interval) has attracted considerable attention during the past 30+ years (PubMed currently lists >17 000 publications). Clinically, a decrease in HRV is correlated to higher morbidity and mortality in diverse conditions, from heart disease to fetal distress. It ...
Malfatto Gabriella G aDivisione di Cardiologia, Ospedale San Luca, Istituto Auxologico Italiano IRCCS bDipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università di Milano-Bicocca, Milan, - - 2014
In chronic heart failure, changes of intra-thoracic impedance (Z0IT) may suggest impending pulmonary congestion; a similar result has been found by measuring trans-thoracic conductance (TFCTT = 1/Z0 = 1/kΩ). We assumed that a relationship could exist between Z0IT and TFCTT. We collected 140 measurements from 70 patients carrying an implantable cardioverter-defibrillator/cardiac resynchronization device with ...
Schmidt Michael Rahbek MR Department of Cardiology, Aarhus University Hospital Skejby, DK-8200 Aarhus N, - - 2014
Conditioning the heart to resist predictable and unpredictable ischemia-reperfusion injury is one of the fastest growing areas of bench to bedside research within cardiology. Basic science has provided important insight into signaling pathways and protective mechanisms in the heart, and a growing number of clinical studies have, with important exceptions, ...
Sugaya Nagisa N Department of Epidemiology and Public Health, Graduate School of Medicine, Yokohama City University, Yokohama, - - 2014
Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) may reflect central noradrenergic activity. In this study, we investigated salivary MHPG changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30 min after awakening to determine MHPG and cortisol. ...
Mine Takanao - - 2014
It is not clear whether patients with sinus rhythm and reduced left ventricular function should be treated with anticoagulation therapy during or after treatment for heart failure. A 67-year-old Japanese man was hospitalized at our institution with heart failure due to dilated cardiomyopathy. On day after discharge, he developed cerebral ...
Li Shujuan S 1Department of Paediatric Cardiology,The First Affiliated Hospital of Sun Yat-Sen - - 2014
Objectives: This study sought to evaluate left ventricular, right ventricular, and left atrial mechanics and their interactions in patients with congenital scoliosis without clinical heart failure. Methods: A total of 23 patients with a median age of 14 years and a median Cobb's angle of 61° were studied. Ventricular and ...
Barold S Serge SS Florida Heart Rhythm Institute, Tampa, - - 2014
Some devices used for cardiac resynchronization therapy (CRT) can sense from the left ventricular (LV) lead as in Biotronik CRT devices (Biotronik GmbH, Berlin, Germany), whose special LV timing cycles form the basis of this report. LV sensing (LVs) was designed to prevent competitive pacing outside the LV myocardial absolute ...
Defauw Arne A Ghent - - 2014
Rotors occurring in the heart underlie the mechanisms of cardiac arrhythmias. Answering the question whether or not the location of rotors is related to local properties of cardiac tissue has important practical applications. This is because ablation of rotors has been shown to be an effective way to fight cardiac ...
Kilic Ana A University of Western - - 2014
Na+/H+ exchanger 1 (NHE-1) inhibition attenuates the hypertrophic response and heart failure in various experimental models. As the hypertrophic program is rapidly initiated following insult we investigated whether early and transient administration of an NHE-1 inhibitor will exert salutary effects on cardiomyocyte hypertrophy or heart failure using both in vitro ...
Yeboah Joseph J Departments of Internal Medicine, Winston - Salem MC; Cardiology, Wake Forest University School of Medicine, Winston - Salem MC; Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC. Electronic address: - - 2014
Limited data exist on the association between LV dilation/remodeling and incident heart failure (HF), especially in adults without prior myocardial infarction and valvular heart disease. We assessed the association between left ventricular (LV) dilation and remodeling, and incident heart failure in a multi ethnic cohort METHODS: 4974 of 6814 participants ...
van Buchem Mark A MA Department of Radiology, Leiden University Medical Center, Leiden, The - - 2014
While both cardiac dysfunction and progressive loss of cognitive functioning are prominent features of an aging population, surprisingly few studies have addressed the link between heart and brain function. This is probably due to the monodisciplinary approach to these problems by cardiologists, neurologists, and geriatricians. Recent data indicate that autoregulation ...
Verbeni Antonella - - 2014
Nowadays advanced heart failure is mainly treated through heart transplantation. However, the low availability of donors makes the research of alternative therapies urgent. Continuous-flow left ventricular assist devices (LVADs) are going to assume a more significant role in assisting the failing heart. A recent challenge in clinical practice is the ...
Chamberlain Alanna M AM Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55905, USA. Electronic address: - - 2014
Comorbidities are a major concern in heart failure, leading to adverse outcomes, increased healthcare utilization, and excess mortality. Nevertheless, the epidemiology of comorbid conditions and differences in their occurrence by type of heart failure and sex are not well documented. The prevalence of 16 chronic conditions defined by the US ...
Kleinbongard P P Institute for Pathophysiology, West German Heart and Vascular Center, University School of Medicine Essen, Essen, - - 2014
In patients with acute myocardial infarction, timely reperfusion is mandatory to limit infarct size. However, reperfusion also adds to myocardial injury. Brief episodes of ischaemia/reperfusion in the myocardium or on organ remote from the heart, prior to or shortly after sustained myocardial ischaemia effectively reduce infarct size, provided there is ...
Wang Lijuan L Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, - - 2014
Aldosterone synthase (CYP11B2) is one of the most studied candidate genes related to essential hypertension (EH) and left ventricular hypertrophy (LVH). Some studies have focused on the relationship between -344C/T polymorphism (rs1799998) in the CYP11B2 gene and LVH, but the results are controversial. This meta-analysis is purposed to reveal the ...
Passino Claudio C Division of Cardiology and Cardiovascular Medicine, Fondazione G. Monasterio CNR-Regione Toscana; Scuola Superiore Sant'Anna, Pisa, Italy. Electronic address: - - 2014
Ventricular remodeling occurs progressively in untreated patients after large myocardial infarction and in those with cardiomyopathy. The pathologic changes of increased left ventricular (LV) volume and perturbation in the LV chamber geometry involves not only the myocytes, but also non-myocyte cells and the extracellular matrix. Inflammation, fibrosis, neuro-hormonal activation, and ...
Buchhorn Reiner R Chefarzt der Klinik Kinder- und Jugendmedizin Caritas-Krankenhaus Uhlandstr. 7 97980 Bad Mergentheim Germany.. - - 2014
The prevalence of heart failure in patients with congenital heart disease, mainly due to large left to right shunts, is as high as 20%. Heart failure has a high impact on prognosis, growth and neurodevelopment. Prior to surgery or after palliative procedures children need a medical heart failure therapy. The ...
Ostman-Smith Ingegerd I Division of Paediatric Cardiology Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Sweden. - - 2014
Congestive cardiac failure accounts for 36% of childhood deaths in hypertrophic cardiomyopathy, and in infants with presentation with heart failure symptoms before two years of age, the mortality is extremely high unless treatment with beta-receptor antagonists is instituted. The mechanism of heart failure is not systolic dysfunction, but rather extreme ...
Prijic Sergej S Pediatric Cardiologist Assistant Professor of Pediatrics Mother and Child Health Institute of Serbia R. Dakica St. 6-8; 11070 Belgrade, Serbia School of Medicine - University of Belgrade Dr Subotica St. 8, 11000 Belgrade, Serbia. - - 2014
Patients with chronic heart failure have prolonged sympathetic stimulation and subsequent worsening of the failing heart function. Beta-blockers (non-selective, cardio-selective, and non-selective with ancillary properties) counteract the effects of prolonged sympathetic stimulation. Beta-blocker therapy results in the improvement of the left ventricular systolic and diastolic function, reversal remodeling, heart rate ...
Prijic Sergej - - 2014
Background.Numerous prospective randomized clinical trials demonstrated favorable effect of beta-blockers in adults with chronic heart failure. However, effectiveness of beta blockers in pediatric patients with systemic ventricle systolic dysfunction was not recognized sufficiently. Limited number of pediatric patients might be the course of unrecognized carvediolol treatment benefit. Currently, no meta-analysis ...
Dodd Michael S MS Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom - - 2014
-Myocardial infarction (MI) is one of the leading causes of heart failure. An increasing body of evidence links alterations in cardiac metabolism and mitochondrial function with the progression of heart disease. The aim of this work was to therefore follow the in vivo mitochondrial metabolic alterations caused by MI, thereby ...
Matsumura Tsuyoshi T Department of Neurology National Hospital Organization Toneyama National Hospital Toneyama 5-1-1 Toyonaka Osaka 550-8552 Japan. - - 2014
Respiratory failure and heart failure are inevitable complications in Duchenne muscular dystrophy (DMD). Respiratory failure and heart failure undergo simultaneously and affect each other. After dissemination of mechanical ventilation, heart failure is the main cause of death in DMD. Regular assessment of cardiopulmonary function, early introduction of cardioprotective therapy and ...
Akhmedov Alexander T AT The Molecular Cardiology and Neuromuscular Institute, 75 Raritan Avenue, Highland Park, NJ, 08904, - - 2014
Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction, progressing eventually to the final end point heart failure (HF), remain the leading cause of morbidity and mortality in the USA. HF is a complex syndrome that results from any structural or functional impairment in ventricular filling or blood ejection. ...
Myles Rachel C RC Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, - - 2014
Heart failure (HF) results in dramatic electrophysiological remodeling, including increased sensitivity of ryanodine receptors (RyR) and decreased inward rectifying K(+) current (IK1), which predisposes HF myocytes to delayed afterdepolarizations and triggered activity. Therefore, we sought to determine the role of increased RyR sensitivity and decreased IK1 in contributing to focal ...
Dawson Alan G AG Department of Cardiothoracic Surgery, Aberdeen Royal Infirmary, Aberdeen, UK - - 2014
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was 'Is the placement of an Amplatzer septal occluder device across a post-infarction ventricular septal defect a suitable alternative for patients not eligible for surgical repair?' Altogether, 31 papers were found using the ...
Swidan M M MM Labeled Compound Department, Hot Labs Center, Atomic Energy Authority, PO13759, Cairo, - - 2014
Acebutolol was successfully labeled with (125) I via direct electrophilic substitution reaction. Radioiodinated acebutolol was prepared with a maximum radiochemical yield of 96.5 ± 0.3% and in vitro stability up to 72 h. The in vivo biological distribution of radioiodinated acebutolol showed high heart uptake of 37.8 ± 0.14% injected activity/g organ with low lungs ...
Ali Abdellah Hamed Khalil AH Department of Respiratory Medicine, Faculty of Medicine, Sohag University, Egypt; Department of Oncological Medical Services, Institute of Health Biosciences, The University of Tokushima Graduate School, - - 2014
The changes of autonomic nervous activity during bronchoscopic procedures are closely related to the development of cardiovascular complications. We aimed to evaluate the changes of autonomic nervous activity during bronchoscopic procedures using R-R interval variability from electrocardiograms obtained during diagnostic bronchoscopy. Twenty-four patients who underwent bronchoscopy were included. Continuous electrocardiogram ...
de Haan S S Department of Cardiology and Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, De Boelelaan 1118, 1081, HV, Amsterdam, the Netherlands, - - 2014
Implantable cardioverter defibrillators (ICD) and cardiac resynchronisation therapy (CRT) have substantially improved the survival of patients with cardiomyopathy. Eligibility for this therapy requires a left ventricular ejection fraction (LVEF) <35 %. This is largely based on studies using echocardiography. Cardiac magnetic resonance imaging (CMR) is increasingly utilised for LVEF assessment, but ...
Catena Cristiana C Hypertension Unit, Division of Internal Medicine, Department of Experimental and Clinical Sciences, University of Udine, 33100, Udine, - - 2014
Both hyperuricaemia and left ventricular (LV) hypertrophy are associated with the metabolic syndrome and increased cardiovascular risk. The relationship between uric acid levels and left ventricular mass in hypertension, however, is unclear. In this study, we have investigated this relationship in hypertensive patients without the metabolic syndrome. In a cross-sectional ...
Scirica Benjamin M BM Brigham and Women's Hospital and Harvard Medical School, Boston, MA - - 2014
-Diabetes and heart failure frequently coexist. However, few diabetes trials have prospectively evaluated and adjudicated heart failure as an endpoint. -16,492 patients with type 2 diabetes and a history of, or at risk for, cardiovascular events were randomized to saxagliptin or placebo (mean followup-2.1 years). The primary endpoint was the ...
Wink Jeroen J From the Department of Anaesthesiology, Leiden University Medical Centre, Leiden, the Netherlands (JW, BTV, PHJA), and Department of Anaesthesia, University Hospitals Ghent, Ghent, Belgium - - 2014
Sympathetic blockade with thoracic epidural anaesthesia (TEA) results in circulatory changes and may directly alter cardiac function. Ageing is associated with an impairment of autonomic nervous system control and a deterioration of myocardial diastolic performance. We postulated that haemodynamic changes induced by TEA could vary with age. An observational study. ...
Rana M S MS Academic Medical Center, University of - - 2014
Rationale: Cardiac progenitor cells from the second heart field (SHF) contribute to rapid growth of the embryonic heart, giving rise to right ventricular and outflow tract myocardium at the arterial pole of the heart, and atrial myocardium at the venous pole. Recent clonal analysis and cell tracing experiments indicate that ...
Feng Han-Zhong HZ Department of Physiology, Wayne State University School of Medicine, Detroit, - - 2014
Abnormal splice-out of the exon 7-encoded segment in the N-terminal variable region of cardiac troponin T (cTnT-ΔE7) was found in turkeys and, together with the inclusion of embryonic exon (eTnT), in adult dogs with a correlation with dilated cardiomyopathy. Overexpression of these cTnT variants in transgenic mouse hearts significantly decreased ...
Garnatz Audrey S AS Committee on Development, Regeneration, and Stem Cell Biology, The University of Chicago, Chicago, IL - - 2014
FOG-2 is a multi-zinc finger protein that binds the transcriptional activator GATA4 and modulates GATA4-mediated regulation of target genes during heart development. Our previous work has demonstrated that the Nucleosome Remodeling and Deacetylase (NuRD) complex physically interacts with FOG-2 and is necessary for FOG-2 mediated repression of GATA4 activity in ...
Nichols Larry L Department of Pathology, University of Pittsburgh Medical - - 2014
Thrombotic thrombocytopenic purpura (TTP) is a rare and potentially fatal disease. Early implementation of therapeutic plasma exchange (TPE) has decreased the mortality rate from >90% to <10%. However, fatalities still occur in these patients. The goal of this study was to characterize the causes of death and related postmortem findings ...
Sacks Chana A - - 2014
With the publication of the PARADIGM-HF trial in the Journal, we may be entering a new era of treatment for heart failure with reduced ejection fraction. To provide a historical perspective on the beginning of this new epoch, we constructed an interactive timeline (available with the full text of this ...
Heidlebaugh Michael M 1 Department of Emergency Medicine, William Beaumont Hospital , Royal Oak, - - 2014
Sudden cardiac arrest is associated with high early mortality, which is largely related to postcardiac arrest syndrome characterized by an acute but often transient decrease in left ventricular (LV) function. The stunned LV provides poor cardiac output, which compounds the initial global insult from hypoperfusion. If employed early, an LV ...
Alonso Erik E Department of Electrical Engineering and Computer Science.University of Stavanger. 4036 Stavanger, Norway; Communications Engineering Department. University of theBasque Country UPV/EHU. Alameda Urquijo S/N 48013 Bilbao, - - 2014
To propose a method which analyses the electrocardiogram (ECG) waveform of any cardiac rhythm occurring during resuscitation and computes the probability of that rhythm converting into another with better prognosis (Pdes). Rhythm transitions occurring spontaneously or due to defibrillation were analysed. For each possible rhythm, ventricular fibrillation/ventricular tachycardia (VF/VT), pulseless ...
Sibilitz Kirstine L KL Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address: - - 2014
We tested the hypothesis that moderately elevated plasma creatinine levels and decreased levels of estimated glomerular filtration rate (eGFR) are associated with increased risk of myocardial infarction, ischemic heart disease, and early death in the general population. We studied 10,489 individuals with a plasma creatinine measurement and calculated eGFR from ...
Cadrin-Tourigny Julia J Electrophysiology Service, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, - - 2014
Despite amiodarone's established safety profile in the setting of heart failure, it is unknown whether its impact on cardiovascular outcomes in patients with atrial fibrillation is modulated by left ventricular function. A pooled analysis of 3307 patients (age 68.0±0.2 years; 31.1% female) enrolled in AFFIRM and AF-CHF trials was conducted ...
Pu Lijin - - 2014
To investigate the effect of cardiac resynchronization therapy (CRT) with right ventricular sense triggered left ventricular pacing for chronic heart failure (CHF). Thirty patients who were eligible for the Class I indication of CRT were enrolled and the informed consents were signed. Left ventricular ejection fraction (LVEF), diastolic mitral flow ...
Kamiński Rafał - - 2014
Background: Atrial fibrillation (AF) is a common arrhythmia in people in elderly and in many cases is responsible for stroke or pulmonary embolism. One of the factors facilitating atrial thrombus formation is anatomical morphology of atria, especially appendages. The pharmacological treatment of arrhythmia generally is focused on ventricular rate control. ...
Satoh Shinji S Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan, - - 2014
Atherosclerosis is a dise ase characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins, those may lead to acute coronary syndrome (ACS). We investigated the expression level of TLR-4 in ACS, as ...
Sankaranarayanan R - - 2014
Atrial fibrillation (AF) continues to impose a significant burden upon healthcare resources. A sustained increase in the ageing population and better survival from conditions such as ischaemic heart disease have ensured that both the incidence and prevalence of AF continue to increase significantly. AF can lead to complications such as ...
Dumotier Berengere M - - 2014
The underlying mechanisms behind cardiac arrhythmias are described in this manuscript. In clinical practice, significant arrhythmias are unpredictable, and under some conditions, potentially life-threatening. How can basic science help improve our understanding of molecular entities and factors behind the arrhythmia to advance, develop, adapt or deliver available medications? Structural heart ...
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