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Kathiria Nazima N NN Department of Radiology, Cardiac and Pulmonary Imaging, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628, USA. Electronic address: - - 2015
Many novel cardiac MR sequences can be used for assessment of adult patients with congenital heart disease. Although most of these techniques are still primarily used in the research arena, there are many potential applications in clinical practice. Advanced cardiac MR assessment of myocardial tissue characterization, flow hemodynamics, and myocardial ...
Kumar Prabhat - - 2015
Implantable cardioverter-defibrillator (ICDs), cardiac resynchronization (CRT) and combination (CRT-D) therapy have become an integral part of the management of patients with heart failure with reduced ejection fraction (HFrEF). ICDs treat ventricular arrhythmia and CRTs improve left ventricular systolic function by resynchronizing ventricular contraction. Device therapies (ICD, CRT-D), have been shown ...
- - 2014
Essential facts Heart failure affects about 900,000 people in the UK. The condition can affect people of all ages, but it is more common in older people, with more than half of all patients over the age of 75. It is caused by the heart failing to pump enough blood ...
Jeon Taegyun - - 2014
Cardiac disease is one of the main causes of catastrophic mortality. Therefore, detecting the symptoms of cardiac disease as early as possible is important for increasing the patient's survival. In this study, a compact and effective architecture for detecting atrial fibrillation (AFib) and myocardial ischemia is proposed. We developed a ...
Rajagopalan Viswanathan V Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd, PO Box 8000, Old Westbury, NY, 11568-8000, USA, - - 2014
Cardiac remodeling includes alterations in molecular, cellular, and interstitial systems contributing to changes in size, shape, and function of the heart. This may be the result of injury, alterations in hemodynamic load, neurohormonal effects, electrical abnormalities, metabolic changes, etc. Thyroid hormones (THs) serve as master regulators for diverse remodeling processes ...
Mann Sarah S University of Pennsylvania School of Nursing, - - 2014
Myocardial infarction (MI) induces cardiac remodeling. This may increase the susceptibility of the infarcted heart to subsequent ischemic events. While chronic angiotensin II blockade is cardioprotective post-MI, the acute effects of angiotensin II in ischemia-reperfusion injury (IR) remains unclear. In the present study, we tested whether angiotensin II administration altered ...
Trappanese Danielle M DM Cardiovascular Research Center, Temple University School of Medicine, 3500 North Broad Street, MERB 1047, Philadelphia, PA, 19140, - - 2015
The β1-adrenergic antagonist metoprolol improves cardiac function in animals and patients with chronic heart failure, isolated mitral regurgitation (MR), and ischemic heart disease, though the molecular mechanisms remain incompletely understood. Metoprolol has been reported to upregulate cardiac expression of β3-adrenergic receptors (β3AR) in animal models. Myocardial β3AR signaling via neuronal ...
Truby Lauren L Department of Surgery, Columbia University Medical Center, New York, NY, - - 2014
Acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) remains associated with significant mortality despite the widespread application of early revascularization strategies. Recent evidence suggests that the use of intra-aortic balloon pump (IABP) counterpulsation does not improve mortality in this cohort of patients. We summarize our experience with mechanical circulatory ...
Hai Ofek Y OY Division of Cardiovascular Medicine, Department of Medicine, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY, - - 2014
Cardiac resynchronization therapy is beneficial in heart failure patients with LVEF ≤35% and electrical dyssynchrony. However, its effects among patients with less severe LV dysfunction have not been established. Recent post-hoc analyses of landmark CRT trials suggest that CRT benefit may be present in patients with LVEF >35% and is ...
Grymyr Ole-Johannes H N OJ The Intervention Centre, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway - - 2014
Miniaturized accelerometers attached to the epicardium have been shown to provide useful clinical information. However, attachment of such a sensor has been cumbersome due to requirement of aligning the three sensor axes with the cardiac coordinate axes, limiting clinical utility. We propose a new method to process the three-dimensional (3D) ...
Zhuang Qin Q Department of Cardiology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, - - 2014
Idiopathic hypereosinophilic syndrome (HES) is a rare leukoproliferative systemic disorder characterized by sustained overproduction of eosinophils and poor prognosis. A case that a 67-year-old man with persistent symptoms of heart failure due to cardiac involvement in idiopathic HES is concentrated on. Echocardiography revealed the marked endocardial thickening of both ventricles ...
Gomes Lilian L Hospital de São Sebastião, Santa Maria da Feira, Portugal. Electronic address: - - 2014
Myotonic dystrophy is a multisystem disease associated with cardiac abnormalities that are responsible for high morbidity and mortality. It commonly affects conduction tissue, resulting in changes in heart rate that tend to progress with age. The aim of the study was to assess overall cardiovascular risk and the risk of ...
Trescher Karola K Department of Cardiac Surgery, LK St. Pölten, Pölten, Austria Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna Medical University, Vienna, Austria - - 2014
Currently available cardioplegic solutions provide excellent protection in patients with normal surgical risk; in high-risk patients, however, such as in emergency coronary artery bypass surgery, there is still room for improvement. As most of the cardioplegic solutions primarily protect myocytes, the addition of substances for protection of the endothelium might ...
Ziacchi Matteo M Department of Experimental, Diagnostic and Specialty Medicine, Institute of Cardiology, University of Bologna, S.Orsola-Malpighi University Hospital, Bologna, Italy *Dr Matteo Ziacchi and Dr Igor Diemberger contributed equally to this - - 2014
Cardiac resynchronization is a well tolerated and effective therapy for heart failure, but 30% of patients still do not respond to biventricular pacing. Optimization of device settings, in particular interventricular delay value, represents a plausible target for improving these results, but available literature is discordant. We aimed our study at ...
Todaro Maria Chiara MC aClinical and Experimental Department of Medicine and Pharmacology, University of Messina, Messina, Italy bAurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, Milwaukee, Wisconsin, - - 2014
Although preserved ejection fraction is found in more than 50% of patients with heart failure, its acceptance as a specific clinical entity is limited. More understanding of the physiopathology, early diagnosis and medical management is needed. With no existing systematic information in the literature, the aim of this review is ...
Pickard Jack M J JM The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London, WC1E 6HX, - - 2015
In 1993, Przyklenk and colleagues made the intriguing experimental observation that 'brief ischemia in one vascular bed also protects remote, virgin myocardium from subsequent sustained coronary artery occlusion' and that this effect '…. may be mediated by factor(s) activated, produced, or transported throughout the heart during brief ischemia/reperfusion'. This seminal ...
Stulc Tomáš T 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, U Nemocnice 1, 128 21, Prague, Czech Republic, - - 2014
Ivabradine is generally considered to be a safe drug with well-established and substantial benefits. Nevertheless, recently published results from the SIGNIFY trial suggest that ivabradine has rather inconsistent effects on cardiovascular outcomes. In addition, careful examination of all available data from ivabradine trials reveals signals of harm that have not ...
Spiro Jon J Department of Cardiology, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, - - 2014
In an effort to improve outcomes in percutaneous coronary intervention (PCI), percutaneous ventricular assist devices (PVADs) have been investigated in (1) high-risk PCI, (2) acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) and (3) in AMI without CS. PCI has become an increasing complex due to an ageing population ...
Zhuang Jianhui J aDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China bCardiology Division, Spedali Civili and University of Brescia, Brescia, Italy cDepartment of Geriatrics, the 113th Hospital of Chinese People's Liberation Army, Ningbo, China dSection of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy eDepartment of Blood Transfusion, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China *Jianhui Zhuang and Pompilio Faggiano contributed equally to the writing of the - - 2014
An increasing number of clinical studies have explored the possibility of using tumor biomarker carbohydrate antigen 125 (CA 125) in the management of patients with heart failure. This systematic review and meta-analysis was performed to comprehensively summarize the available evidence and evaluate the applicability of CA 125 in heart failure. ...
Neragi-Miandoab S S Department of Cardiothoracic Surgery Montefiore Medical Center Albert Einstein College of Medicine Bronx, NY, USA - - - 2014
Congestive heart failure (CHF) results from damage to the myocardium and has a broad etiology ranging from ischemic to non-ischemic etiology. It is one of the leading causes of cardiovascular morbidity and mortality and carries a 5-year mortality of 50%, estimated by WHO to represent 30% of deaths in the ...
Cabianca Nancy N Nancy Cabianca is a staff nurse at the Queen's Medical Center, Honolulu, HI. Contact author: allupthecreek@hotmail.com. Reflections is coordinated by Madeleine Mysko, MA, RN: - - 2014
A lasting payoff for the long shifts and lost personal time.
Pellicori Pierpaolo P Department of Cardiology, Hull York Medical School, Hull, UK - - 2014
Many patients with heart failure (HF) have a normal left ventricular ejection fraction, and are labelled as having HF with preserved left ventricular ejection fraction (HFPEF). Hypertension, atrial fibrillation and age are important contributors to the development of HFPEF and, therefore, its prevalence is likely to increase in the next ...
Zhang Qing Q aDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan bDivision of Cardiology, Anzhen Hospital, Capital Medical University, Beijing cDivision of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, - - 2014
Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in patients with mild-to-severe heart failure. However, up to 40% of CRT recipients are nonresponders. This review addresses important aspects with regard to the identification and management of CRT nonresponders. Mid-term clinical or echocardiographic nonresponse is associated with worse clinical outcomes during ...
Williams Paul D PD James Cook University Hospital, Marton Road, Middlesbrough, United Kingdom TS4 3BW. - - 2014
Right heart catheterization has been described via the arm but previous reports have been retrospective, performed for limited indications, and may not give an accurate assessment of the success rate or safety of this technique. We sought to prospectively examine the feasibility and safety of left and right heart catheterization ...
Li Zhao-Jun ZJ Department of Ultrasound, First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, 200080, China, - - 2014
The elastic and functional coupling of heart and vessels makes the stroke work (SW) of the heart optimal. Speckle tracking imaging (STI) can evaluate the myocardial strain and function. We studied ventricular-vascular coupling in 80 diabetic patients with different systolic function using STI. The patients were divided into two groups ...
Nagwekar J J Department of Cell Biology and Center for Fluorescence Technology and Nanomedicine, University of North Texas Health Science Center , 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, United - - 2014
The contraction of the right ventricle (RV) expels blood into the pulmonary circulation, and the contraction of the left ventricle (LV) pumps blood into the systemic circulation through the aorta. The respective afterloads imposed on the LV and RV by aortic and pulmonary artery pressures create very different mechanical requirements ...
Vogel Rebecca R The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, 1 Discovery Drive, Rensselaer, NY 12144, - - 2014
Research shows that various types of stem cells (SCs) have the ability to rebuild damaged heart tissue. The TIME and Late TIME human trials shed light on the optimum timing of SC therapy administration after myocardial damage. The FOCUS study failed to show a substantial positive effect of bone marrow-derived ...
Alva M L ML Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK; RTI International, Washington, DC, - - 2014
To estimate the immediate and long-term inpatient and non-inpatient costs for Type 2 diabetes-related complications. The costs of all consultations, visits, admissions and procedures associated with diabetes-related complications during UK Prospective Diabetes Study post-trial monitoring in the period 1997-2007 were estimated using hospitalization records for 2791 patients in England and ...
Nogaret Alain A Department of Physics, University of Bath, Bath, BA2 7AY, UK - - 2014
Cardiac rhythm management devices provide therapies for both arrhythmias and resynchronization but not heart failure, which affects millions of patients worldwide. This paper reviews recent advances in biophysics and mathematical engineering that provide a novel technological platform for addressing heart disease and enabling beat-to-beat adaptation of cardiac pacing in response ...
Allida Sabine M SM Centre for Cardiovascular & Chronic Care, Faculty of Health, University of Technology Sydney, Broadway, NSW, - - 2014
This review will (1) explore factors related to thirst in chronic heart failure and (2) describe interventions to alleviate thirst in chronic heart failure patients. Thirst is a common and troublesome symptom of chronic heart failure. Despite the burden and prevalence of this symptom, there are limited strategies to assist ...
Sun Bei B Yantaishan Hospital, Yantai, 264000, Shandong, People's Republic of - - 2014
This study aimed to investigate the effect of total flavonoids of Choerospondias axillaris (TFC) on myocardial infarction (MI)-induced cardiac dysfunction, interstitial fibrosis and inflammatory reaction and further to clarify the potential signaling pathway involved. Rats were subjected to MI via coronary artery occlusion. The model establishment was confirmed by the ...
Schwartzman David D Heart, Lung and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, - - 2014
Atrial fibrillation (AF) is frequently comorbid in patients receiving cardiac resynchronization therapy (CRT), and suppression is typically difficult. Herein, we sought to understand the benefit of atrial rhythm control in the setting of ventricular rate and regularity control induced by atrioventricular node (AVN) ablation. Fifty-two patients with heart failure, persistent ...
Soler Fernando F Department of Biochemistry and Molecular Biology A, University of Murcia, 30100 Murcia, - - 2014
The important regulator of cardiac function, cAMP, is hydrolyzed by different cyclic nucleotide phosphodiesterases (PDEs), whose expression and activity are not uniform throughout the heart. Of these enzymes, PDE2 shapes β1 adrenoceptor-dependent cardiac cAMP signaling, both in the right and left ventricular myocardium, but its role in regulating β2 adrenoceptor-mediated ...
Correale Michele - - 2014
Clinical trials demonstrated that statin therapy is associated with a significant reduction in cardiovascular morbidity and mortality when used for either primary or secondary prevention of cardiovascular events. Several studies have shown that statins, having an important effect in the prevention of acute coronary syndromes, are also able to prevent ...
- - 2014
Essential facts Cardiopulmonary resuscitation (CPR) is a treatment to restart the heart after cardiac arrest. Cardiorespiratory arrest is part of the final stage of dying, and health professionals can be involved in extremely difficult decisions about whether to give CPR to people when their heart stops or they stop breathing. ...
Athyros Vasilios G VG Head of Metabolic Disease and Atherosclerosis Units, Second Prop. Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece. - - 2014
Heart failure with preserved ejection fraction (HFpEF). Arterial hypertension (AH), arterial stiffness (AS), older age, and female gender are the main determinants of HFpEF, but several cardiac or extra-cardiac pathologies are also possible causes. The combined ventricular-vascular stiffening (abnormal left atrium-left ventricle coupling related to AS) is the main contributor ...
Perea Rosario J RJ Radiology Department. Hospital Clinic, University of Barcelona, Barcelona, Spain, - - 2014
Myocardial fibrosis is always present in end-stage heart failure and is a major independent predictor of adverse cardiac outcome. Cardiac magnetic resonance (CMR) is an imaging method that permits a non-invasive assessment of the heart and has been established as the "gold standard" for the evaluation of cardiac anatomy and ...
Grandin Wilson W Division of Cardiology, University of Pennsylvania, Philadelphia, - - 2014
Carfilzomib is a novel irreversible proteasome inhibitor (PI) used with increasing frequency to treat patients with relapsed and/or refractory multiple myeloma (RRMM). This agent is an effective treatment for this challenging population, but proteasome inhibition has the potential for significant cardiac toxicity via the accumulation of intracellular protein aggregates. Although ...
Lazo Mariana M Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore Maryland; Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Electronic address: - - 2014
Patients with non-alcoholic fatty liver disease (NAFLD) are thought to be at increased risk of cardiovascular morbidity and mortality. However, the relationships NAFLD to subclinical myocardial injury or structural heart disease are unknown. We conducted a cross-sectional analysis of 8668 participants from the Atherosclerosis Risk in the Communities (ARIC) Study ...
Moyzis Alexandra G - - 2014
The heart is highly energy dependent with most of its energy provided by mitochondrial oxidative phosphorylation. Mitochondria also play a role in many other essential cellular processes including metabolite synthesis and calcium storage. Therefore, maintaining a functional population of mitochondria is critical for cardiac function. Efficient degradation and replacement of ...
Ratto Elena E I.R.C.C.S. Azienda Ospedaliera Universitaria San Martino-IST, Genova, - - 2014
A new classification of left ventricular geometry based on left ventricular dilatation and concentricity has recently been developed. This classification identifies subgroups differing with regard to systemic haemodynamics, left ventricular function and cardiovascular prognosis. We investigated the relationship between the new classification of left ventricular geometry and subclinical renal damage, ...
Soucy Kevin G KG 1Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, KY 40202 2Department of Bioengineering, University of Louisville, Louisville, KY 40202 3Cardiovascualr Innovation Institute, University of Louisville, Louisville, KY 40202 4Department of Medicine, University of Louisville, Louisville, KY 40202 5Department of Pediatrics, University of Louisville, Louisville, KY 40202 6CorMatrix Cardiovascular, Inc., Roswell, GA 30076 7Research Resource Facilities, University of Louisville, Louisville, KY - - 2014
Myocardial recovery with LVAD support is uncommon and unpredictable. We tested the hypothesis that injectable particulate extracellular matrix (P-ECM) with left ventricular assist device (LVAD) support promotes cell proliferation and improves cardiac function. LVAD, P-ECM, and P-ECM+LVAD therapies were investigated in 60-day (n=6) and 90-day (n=6) chronic ischemic heart failure ...
Mentz Robert J RJ Duke University, Durham, North Carolina. Electronic address: - - 2014
Heart failure patients are classified by ejection fraction (EF) into distinct groups: heart failure with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction (HFrEF). Although patients with heart failure commonly have multiple comorbidities that complicate management and may adversely affect outcomes, their role in the HFpEF and ...
Maksuti Elira E Department of Medical Engineering, School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden. Electronic address: - - 2014
Medical imaging and clinical studies have proven that the heart pumps by means of minor outer volume changes and back-and-forth longitudinal movements in the atrioventricular (AV) region. The magnitude of AV-plane displacement has also shown to be a reliable index for diagnosis of heart failure. Despite this, AV-plane displacement is ...
Adachi Toru T Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, - - 2014
-Septal atrial tachycardia (AT) can occur in patients without structural heart disease and in patients with prior catheter ablation of atrial fibrillation. We aimed to assess septal AT that occurs after open-heart surgery. -This study comprised 20 consecutive patients undergoing catheter ablation of macroreentrant AT after open-heart surgery. Relevance to ...
Raje Vikram P VP Department of Internal Medicine, Division of Cardiovascular Disease. Virginia Commonwealth University†. Hunter Holmes McGuire Veterans Medical - - 2014
Dobutamine is a rare and unrecognized cause of eosinophilic myocarditis. It is even more unique for it to cause significant clinical deterioration. Patients with end stage cardiomyopathy have very little cardiac reserve and dobutamine induced myocarditis may cause enough harm to require urgent mechanical circulatory support. We describe a man ...
Bruns Danielle R DR University of Colorado - - 2014
Right ventricular (RV) function is a key determinant of survival in patients with both right and left ventricular failure, yet the mechanisms of RV failure are poorly understood. Recent studies suggest cardiac metabolism is altered in RV failure in pulmonary hypertension (PH). Accordingly, we assessed mitochondrial content, dynamics and function ...
Lee Sung Ho SH Division of Cardiology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, - - 2014
We applied cardiac resynchronization therapy (CRT) for desynchronized heart failure patients. We evaluated clinical outcomes including morbidity, mortality, and echocardiographic parameters in 47 patients with implanted CRT in Korea from October 2005 to May 2013. The combined outcomes of hospitalization from heart failure, heart transplantation and death were the primary ...
Hasun Matthias M 2. Medizinische Abteilung, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Vienna, - - 2014
Atrial fibrillation (AF) is by far the most frequent heart rhythm disorder and is associated with a significantly increased risk of stroke, heart failure and death. Despite improvements in prevention and treatment, the prognosis has not changed significantly. To use new and promising pharmacological and interventional concepts for thromboembolic prophylaxis ...
Malik Rabiya R Cardiovascular Center, Tufts Medical Center, Tufts University School of Medicine, Boston, - - 2014
Ectopia cordis, defined as partial or complete displacement of the heart outside of the thoracic cavity, is a rare congenital malformation. If not surgically corrected during the early years of life, ectopia cordis can prove to be a fatal abnormality. However, due to the presence of multiple intracardiac and extracardiac ...
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