Search Results
Results 351 - 400 of 504
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Thomsen H - - 1994
C5b-9(m) is a specific and sensitive marker for myocardial cell necrosis. The diagnostic value of this marker would be considerably limited in forensic practice if its immuno-histochemical demonstration were hampered by putrefaction or autolysis. We could demonstrate C5b-9(m) immunohistochemically in necrotic myocardium due to infarction up to the 11th day ...
Regodon S - - 1993
A technique is described for catheterisation of the ventricular recess within the olfactory bulb of the horse. Twelve adult horses were used. The olfactory recess is in the frontal region, 42 +/- 3 mm below the skin, on the line joining the supraorbital foramina, and approximately 18 +/- 2 mm ...
Maslov L N - - 1993
We studied antiarrhythmic action of D-Ala 2, Leu 5, Arg 6-enkephalin (dalargin) in experiments on male rats. Dalargin is reported to prevent heart rhythm disturbance and heart electrical stability decrease in experimental coronary occlusion, postinfarction, cardiosclerosis and emotional stress. Dalargin prevents acute myocardial ischaemia-induced increase of cAMP content in blood ...
Holmbom B - - 1993
Staining with triphenyltetrazolium chloride (TTC), although controversial, has frequently been used for the delineation of myocardial infarction. This study was performed further to explore the reliability of the TTC method. In 24-h experiments pigs were subjected to closed-chest occlusion of the left anterior descending coronary artery for 30, 60 or ...
Otsuji S - - 1993
We examined the effects of dietary supplementation with eicosapentaenoic acid (EPA) on experimental myocardial infarction in dogs. Twenty-five dogs were fed standard diets, 10 of which were supplemented with EPA-ester (100 mg/kg body weight/day) for 8 weeks, while 15 served as controls. After ingesting EPA for 8 weeks, the ratio ...
Männer J - - 1993
In chick embryos, the formation of the epicardium proceeds from the attachment of a secondary sinuventricular mesocardium. This mesocardium is formed by the adhesion of pericardial villi with the dorsal surface of the heart. It was the aim of this study to clarify the role of the pericardial villi in ...
Humphrey J D - - 1992
We present a new theoretically motivated experimental approach for identifying the functional form of a constitutive relation for any nonlinear, anisotropic pseudoelastic biological membrane. The utility of this approach is illustrated by identifying, from biaxial data, a new constitutive relation for excised ventricular epicardium. Values of the associated material parameters ...
Yao Y - - 1992
In this study, an animal model of multiple system organ failure (MSOF) in rabbits, engendered by feeding E. coli prior to severe hemorrhagic shock, was used for the purpose of investigating 1) the relationship between lipopolysaccharide (LPS) and MSOF, and 2) the effectiveness of Re-LPS antiserum in preventing MSOF. The ...
Grevelink S A - - 1992
BACKGROUND: Despite extensive research on hyposensitization and prior application of topical barrier preparations, efforts to prevent Toxicodendron dermatitis have been only minimally successful. OBJECTIVE: Seven different barrier creams were evaluated for topical protection against experimentally produced Toxicodendron dermatitis in a randomized, double-blind study. METHODS: Twenty patients had the seven barrier ...
Torchilin V P - - 1992
The less than optimal accumulation of immunoliposome-associated reagents at target sites has often been attributed to the rapid in vivo clearance of immunoliposomes from the blood. In an attempt to overcome the drawback of rapid clearance and use the targeting potential of immunoliposomes, we have prepared long-circulating, 111In-labeled immunoliposomes. Targeting ...
Eliskova M - - 1992
In ten postmortem hearts of the Macaque monkey (M. mulatta), the coronary lymphatics were visualized using an India ink suspension in 2% gelatin. The left coronary lymphatic initially passed to the dorsal surface of the aortic arch. In five hearts, this lymphatic went directly to the cardiac lymph node, whereas ...
Meller S T - - 1992
There is considerable evidence that on the anterior surface of the heart (which is usually supplied by the left anterior descending and the proximal part of the left circumflex coronary arteries), sympathetic efferent reflexes characterized by tachycardia and/or hypertension predominate following experimental or pathological perturbations. These cardiovascular reflexes are accompanied ...
Wit A L - - 1992
Experimental animal models of ventricular arrhythmias have been developed to elucidate mechanisms of arrhythmogenesis in humans. Studies of animal models have enabled the vulnerable period of the ventricles to be discovered and characterized and should eventually lead to improved techniques of defibrillation. Animal models of ischemic heart disease and myocardial ...
Mulholland C W - - 1991
Serum total free radical trapping abilities (TRAP experimental) were measured in 15 patients with acute myocardial infarction (AMI) and compared to sex- and age-matched controls. TRAP experimental values were significantly lower (p less than 0.01) in the AMI group. Theoretical trapping abilities were also calculated and compared with experimentally derived ...
Dworkin G H - - 1991
The technique of heterotopically transplanting a rabbit heart into the abdominal position of a recipient rabbit is discussed. Myocardial preservation, vascular anatomy of the recipient, and general anesthetic considerations are described, as are techniques to avoid anesthetic death, hemorrhage, and paraplegia. Application of these techniques to experimental models of accelerated ...
Nakada T - - 1991
Intracellular pH levels of infarcted brain determined by phosphorus-31 nuclear magnetic resonance (NMR) spectroscopy disclosed a notable phenomenon. The acidotic brain pH seen in the acute stage of infarction was observed to rebound into the alkalotic range in the subacute phase before returning to the normal range in the chronic ...
Yost H J - - 1991
The heart and viscera of vertebrates are formed from primordia that are apparently bilaterally symmetrical. This symmetry is broken during development, yielding organs that develop characteristic asymmetries along the left-right axis. Results from three lines of experimentation on embryos of the amphibian Xenopus laevis indicate that left-right asymmetries are established ...
Holmbom B - - 1991
A method for large specimen cryosectioning is described. Specimens of pig heart ventricles were lightly fixed by microwave irradiation, embedded in 10% gelatin, frozen in hexan chilled with dry ice, and sectioned using an LKB 2250 PMW cryomicrotome. The sections were collected on transparent film and transferred onto glass slides. ...
van der Walt J J - - 1990
ST-segment changes in the ECG, which are an indication of acute myocardial ischaemia, are obtained when a small quantity of an extract from dried Pachystigma pygmaeum is injected intravenously in sheep. When the fraction was injected subcutaneously, animals reached a crisis after about 5 h, with low values of stroke ...
Ornish D - - 1990
In a prospective, randomised, controlled trial to determine whether comprehensive lifestyle changes affect coronary atherosclerosis after 1 year, 28 patients were assigned to an experimental group (low-fat vegetarian diet, stopping smoking, stress management training, and moderate exercise) and 20 to a usual-care control group. 195 coronary artery lesions were analysed ...
Xu G X - - 1990
Four methods for encapsulating adenosine triphosphate (ATP) in liposomes were evaluated. Optimum entrapment required emulsifying ATP with the lipids used to form the liposome membrane in a high-speed homogenizer followed by evaporating the organic solvent with vigorous stirring. Under these optimum conditions ATP entrapment was 38.9%; i.e., the dosage form ...
Shekhonin B V - - 1990
Distribution of fibrinogen/fibrin and fibronectin in regions of experimental myocardial infarction were studied by the immunofluorescence technique. Distinct from normal myocardium 3 and 12 to 24 h after coronary artery ligation infiltration of necrotized cardiomyocytes by fibrinogen/fibrin and plasma fibronectin was detected. Fibrinogen/fibrin and plasma fibronectin constitute "primary matrix" of ...
Reeves W C - - 1990
The relationship between digoxin administration and the development of doxorubicin cardiomyopathy was evaluated in a chronic experimental rabbit model. We graded the myocardial pathology by conventional light microscopic histologic techniques. Additionally, myocardial fibrosis was quantified by hydroxyproline determinations and myocardial cellular damage by technetium-99m pyrophosphate uptake. Twenty-four rabbits were studied: ...
Otsuka K - - 1990
Recent advances of the chronobiologic approach to experimental and clinical cardiology was reviewed. First, the maximum entropy method (MEM) was introduced as one of the statistical methods analyzing the circadian periodicity. The MEM power spectrum showed a remarkable resolution property. It will play an important role in chronocardiology in cooperation ...
Mehta P M - - 1990
Several experimental studies have suggested that the sulphydryl-containing angiotensin-converting enzyme inhibitor, captopril, has cardioprotective effects in the setting of acute myocardial ischaemia, ischaemia/reperfusion and infarction. We have observed that captopril can reduce the degree of dilatation and early functional myocardial infarct expansion produced by 3 h of permanent coronary artery ...
Khaw B A - - 1990
Monoclonal antimyosin Fab (AM-Fab) was radiolabeled with 111In via a new bifunctional chelating agent, isothiocyanatobenzyl-DTPA (SCN-DTPA), and used to visualize acute reperfused experimental myocardial infarction. Antibody localization was compared to 201Tl (0.6 mCi) distribution in nine animals. Each animal was injected intravenously with 0.5 mCi of 111In-SCN-DTPA AM-Fab preparations (Prep ...
Reeves W C - - 1990
An experimental animal model was utilized to evaluate the role of simultaneous two-dimensional echocardiography combined with a modified electrocardiographic monitoring technique for improving the safety of pericardiocentesis. This technique avoids the hazards of placing the sharp pericardiocentesis needle against the heart in order to determine its location against the epicardial ...
Biver P - - 1990
Endogenous factors with biological and immunological activity similar to cardiac glycoside drugs (endogenous digitalis-like factors; EDLF) have been found in several tissues and body fluids of animals and humans. Detectable EDLF concentrations were found in blood and urine extracts of adults (normal healthy controls, hypertensive patients and salt-loaded healthy subjects), ...
Kadish A - - 1989
The maximum amplitude of vector loops formed by summing orthogonally recorded bipolar electrograms has been shown to reflect the direction of activation in cardiac muscle. To investigate whether components of vector loops could provide information about different activation directions in local areas of myocardium, we correlated "instantaneous vectors" with isochronal ...
Duska F - - 1988
99mTc-aminohexylidendiphosphonate (99mTc-AHDP) is a new Czechoslovak pharmaceutical of the phosphonate line which contains the amino group NH2 in its molecule. This substance was tested in 5 dogs with experimentally provoked 48-h old myocardial infarction. The in-vivo scan and the radioactivity of tissue samples demonstrated that 99mTc-AHDP is as suitable for ...
Tinker J H - - 1988
I have tried to summarize experimental work in human and animal models. This work is complex and difficult to interpret. Clinicians should not take isolated experimental studies and jump to conclusions about clinical use of anaesthetics. Experimenters should not arrive at sweeping conclusions based on a particular experimental study performed ...
Tinker J H - - 1988
I have tried to summarize experimental work in human and animal models. This work is complex and difficult to interpret. Clinicians should not take isolated experimental studies and jump to conclusions about clinical use of anaesthetics. Experimenters should not arrive at sweeping conclusions based on a particular experimental study performed ...
BÅ‚och P - - 1988
Ultrastereologic studies were performed on myocardial mitochondria in experimental hypothyroidism induced by the excision of the thyroid gland. Studies were carried out using accepted methods in stereology according to Weibel et al. Mitochondrial membrane surface areas and relative volumes of individual membranes and compartments were calculated by means of Weibel's ...
Natelson B H - - 1987
Evidence exists for the presence of a neuro-anatomy that can produce cardiac vasospasm. Recent experimental and clinical data suggest that this neuro-anatomic mechanism can be activated by behavioral events in the psycho-social surround of the patient with coronary artery disease. I hypothesize that this mechanism can produce myocardial ischemia and ...
Jensen J A - - 1987
The standard coronary ligation model for experimental myocardial infarction results in variable areas and patterns of necrosis; therefore, the healing of such infarctions is also variable. The authors developed an experimental myocardial injury model using simple cryoinjury, which allows standardization of the size, depth, and location of the wound. Thirty-eight ...
Boor P J - - 1987
The chemistry, industrial usage, general toxicity, and experimental use of allylamine are briefly reviewed. This highly reactive unsaturated alkylamine has had industrial applications in a variety of organic processes, and continues to be utilized, although accurate data concerning production is not readily available. The general toxic effects of the freebase ...
Schulzke J D - - 1987
Self-filling blind loops of rat jejunum exhibit hyperregenerative transformation of the mucosa. We used this experimental model to characterise mechanisms, which may occur under similar conditions in man (stagnant loop syndrome). Epithelial and subepithelial resistance were measured in the Ussing-chamber by voltage divider ratio measurements after positioning a microelectrode between ...
Janetschek G - - 1987
Experimental testicular torsion must be used for certain studies of clinical relevance, but most experimental models either do not provide hemodynamic alteration comparable to the clinical situation or cannot guarantee reproducibility. Using a rat model arterial perfusion and hemorrhagic infarction were correlated to the degree of both intra- and extravaginal ...
Vrána M - - 1987
1. Benzodiazepines and strong analgesics raise considerably the ventricular fibrillation threshold and thus electrically stabilize the heart in the early stage of myocardial ischaemia. 2. Benzodiazepines markedly potentiate the electrostabilizing effect of the beta-blocker metipranolol. 3. Trimecaine per se does not electrically stabilize the heart in the first hour of ...
Friedman M - - 1986
One thousand thirteen post myocardial infarction patients were observed for 4.5 years to determine whether their type A (coronary-prone) behavior could be altered and the effect such alteration might have on the subsequent cardiac morbidity and mortality rates of these individuals. Eight hundred sixty-two of these individuals were randomly assigned ...
Allwork S P - - 1986
To evaluate the histological phenomenon of fluorescence of necrotic myocardium in ultraviolet light a prospective study of fatal myocardial infarction with accurate clinical and biochemical correlation was made. To test the morphological characteristics and specificity of the technique experimental infarctions were induced surgically in sheep and pigs and acute ischaemia ...
Friedli H P - - 1986
The effect of pindolol on experimental myocardial infarction was studied in a pig model. Intravenous application of 0.05 mg pindolol per kg body weight was initiated one hour after coronary ligation and repeated at 12-hour intervals for five days. No significant difference in infarct size could be found between pindolol-treated ...
Rakusan K - - 1986
The key to understanding the mechanics of capillary proliferation probably lies in comprehension of the normal capillary growth during the early postnatal period when most of the terminal vessels in mammalian hearts are being formed. Similarly, stimulated cardiac growth is accompanied mainly, but not exclusively, by capillary proliferation if it ...
Naggan L - - 1986
Epidemiologic methods provide a basis for evaluating new medical technologies of varying complexity and sophistication. Use is made of the concepts of efficacy, effectiveness and efficiency, and cost-effectiveness. The available methods, observational and experimental, are reviewed in the context of evaluation of the intensive coronary care unit (ICCU). Most early ...
Marchetti G - - 1986
The activity of ibopamine (SB-7505), the 3,4-diisobutyryl ester of N-methyldopamine, on myocardial contractility and systemic and renal hemodynamics was investigated in the anesthetized dog with experimental infarction, instrumented with catheters and electromagnetic flowmeters. Ibopamine, given by the intraduodenal route at a dose of 24 mg/kg, was effective in improving the ...
Banitt E H - - 1986
The antiarrhythmic agent flecainide acetate was resolved by fractional crystallization of its diastereomeric alpha-bromocamphor-pi-sulfonate salts. Optical purity of the two enantiomers was shown to be greater than 99% by an NMR technique using the chiral shift reagent Eu(hfbc)3. Antiarrhythmic effects of flecainide and its enantiomers were assessed in two different ...
Markiewicz W - - 1986
We compared the action of alfentanil on experimental myocardial infarction size with two widely used anesthetic drugs: fentanyl and halothane. Myocardial infarction size, measured by histological techniques, was identical for the three drugs investigated. Our results demonstrate that the action of alfentanil on factors governing myocardial oxygen supply and demand ...
Berti F - - 1986
Defibrotide is a polydeoxyribonucleotide of mammalian origin which possesses profibrinolytic effect and PGI2-releasing capacity. Because of these properties, defibrotide has antithrombotic effects which are demonstrated in various experimental models of venous and arterial thrombosis. The present study indicates that defibrotide clearly protects against myocardial damage in the rabbit 3 days ...
Dor X - - 1985
It seems difficult to escape the conclusion that conotruncal migration and torsions do occur: The amplitude, direction and timing of these movements can be accurately tracked and they can be experimentally arrested. The movements have a significant function: Associated with the partitionings, they regulate the outlet ventricular distribution at two ...
Opie L H - - 1985
Calcium antagonists are an important new modality in cardiovascular therapy. Tiapamil, a congener of verapamil, is undergoing clinical and laboratory evaluation. We have undertaken experimental studies on the anti-arrhythmic properties of tiapamil, and on the intravenous use of this agent in patients with acute myocardial infarction. Reasons are given for ...
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