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Results 301 - 350 of 393
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Hood W B WB - - 1983
Much of our knowledge about the effects of coronary occlusion and reperfusion is derived from studies in experimental animals. The recent discovery that coronary thrombosis is usually present in clinical myocardial infarction and that thrombolysis represents an approach to therapy presents opportunities for further experimental work. Animal models are particularly ...
Jacob H S - - 1983
C5A is capable of causing granulocyte/granulocyte interactions that lead to clumping, vasoocclusion, and the extension of infarctive damage in patients with coronary artery disease. Employing a new rheologic procedure, laser transillumination of thin vascular beds, one directly observes in vivo granulocyte aggregation in the mesentery of the rat. Nonsteroidal antiinflammatory ...
Hofmeyr G J - - 1983
The sequence of fetal heart rate (FHR) changes recorded in a case of acute fetal haemorrhage is reported. Initial bradycardia progressed through an undulatory phase to tachycardia. Analysis of these patterns in the context of experimental data on intrinsic heart rate control suggests that the FHR was limited by availability ...
Chien K R - - 1983
Ligation of the circumflex artery of anaesthetised, open-chest rabbits caused a progressive increase in nonsedimentable cathepsin D activity in severely ischaemic myocardium and an anatomical redistribution of the enzyme from lysosomes into the cytosol, along with progressive ultrastructural signs of cellular damage and necrosis. Chlorpromazine pretreatment (15 mg X kg-1 ...
Thomas A C - - 1983
The practical value of measuring the ratio of potassium ion (K+) to sodium ion (Na+) in myocardium as an indicator of early inapparent infarction in sudden cardiac death was assessed using a series of 29 human hearts from selected coroner's autopsies together with experimental material from dogs, including infarcts of ...
Al-Rufaie H K - - 1983
A retrospective study has been carried out on the necropsy material from 30 patients who have died after a clinically diagnosed myocardial infarction. This study has been undertaken to compare the reliability of the fluorescence of infarcted myocardium when stained by haematoxylin and eosin and an adjacent section stained by ...
Zatz L M - - 1983
The planimetric measurement of the area of the ventricles on a computed tomographic section is a convenient and useful method of assessing ventricular size when more sophisticated techniques are not available. It is commonly reported as a planimetric ventricular-brain ratio or VBR. Ventricular size is related to cranial size in ...
O'Connor W N - - 1983
Experimental myocardial infarction of the posterolateral left ventricular wall in 2 dog hearts, the result of 1 h of occlusion of the left circumflex coronary artery followed by 4 days of reperfusion, was studied post mortem by serial histological sectioning. Microscopic examination in a transverse plane showed a zone of ...
Hearse D J - - 1983
At the present time our experimental findings plus the weight of other experimental evidence suggest that there is unlikely to be a quantitatively significant border zone in the lateral plane. The transition from normal to ischemic tissue is likely to be accomplished over a distance of 1.0 mm or less ...
Meerson F Z - - 1982
A working hypothesis on pathogenesis of ischemic heart damage has been proposed. According to this hypothesis, a crucial role in conversion of reversible damage into irreversible damage is played by cardiomyocyte membrane destruction caused by the so-called "lipid triad". The latter comprises activation of lipid peroxidation, activation of phospholipases, and ...
Antalóczy Z - - 1982
Under experimental conditions, potassium canrenoate causes a significant increase in [3H]norepinephrine (NE) uptake by the heart, although the NE content remains unchanged. The increased NE uptake and unchanged NE content indicate an augmented NE turnover caused by the drug. In saluretic-pretreated animals, the intracellular hypopotassemia can be restored by Aldactone. ...
Milei J - - 1982
The normal electrocardiographic (ECG) pattern was determined for Cebus monkeys and compared with those obtained in animals subjected to experimental heart damage. ECG patterns were related to the anatomopathological findings in both normal and treated animals. The anatomic study revealed a vertical heart in which both ventricles constituted the frontal ...
Faarup P - - 1982
Infarcts of the rabbit kidney were experimentally induced in 22 animals by selective left renal arteriography using the genuine foreign bodies present in the contrast media and catheters as damaging agents. Three days later the infarcts were macroscopically located and measured at laparotomy. Three weeks later the infarcts were macroscopically ...
Tanaka T - - 1982
The influence of differential washout on the redistribution phenomenon of thallium 201 chloride deposited in ischemic myocardium was investigated. Two groups of dogs had serial scintigraphic images and tissue counting performed. The first group had ischemia produced prior to the injection of the thallium and, following the control image after ...
Uherík A - - 1982
The hypothesis on the relationship between biofeedback and the psychophysiological regulatory properties of Ss was tested experimentally. The Ss were 17 adult males after myocardial infarction, 13 patients with bronchial asthma and 18 healthy adults. Biofeedback was followed through a continuous bioelectrical skin reactivity (BSR) recording as an indicator of ...
Samuel J L - - 1981
Histoenzymological techniques were used to examine ATPase activity in rat heart muscle fibres after experimental infarction. 25 hours after coronary ligation, ATPase activity in all ventricular section fibres was high, homogeneous at pH 9.4, sections. 48 hours after ligation, necrotic ventricular fibres appeared, leaving only a thin layer of fibres ...
Hugod C - - 1981
Rabbits were continuously exposed to 200 ppm carbon monoxide. Using the same criteria as applied by earlier investigators for morphological myocardial damage, no histotoxic effect on myocardial morphology could be demonstrated when electron-microscopic investigations were performed blindly. Similarly, exposure to 0.5 ppm hydrogen cyanide, 0.5 ppm hydrogen cyanide + 200 ...
Polson H - - 1981
Results of our experimental studies have demonstrated that, during the evolution of mesenteric infarction, lysosomal membrane instability occurs with the release of beta-N acetylhexosaminidase into the portal and systemic circulation. Preliminary clinical results suggest an elevation of the Hex B fraction in mesenteric infarction. Measurements of total and various fractions ...
Unger T - - 1981
Listeners who had demonstrated right-ear dichotic listening preference in the first of four listening sessions were randomly assigned to an experimental and control group. Both groups participated in three more dichotic listening sessions. For sessions 2 and 3, left-ear responses were reinforced for the experimental group listeners. There was a ...
Katzeff I E - - 1981
This paper experimentally evaluates the "imaginary cardiac vector" hypothesis, that the cardiac vector is not a real vector. We have previously shown on theoretical grounds that the basis of the cardiac vector is invalid in that Einthoven used scalar, not vector, procedures. Attempts by subsequent workers to compensate for the ...
Raku┼Łan K - - 1981
Quantitative evaluation of the myocardial left ventricular capillarity was performed in three groups of guinea pigs: a) animals native to high altitude collected in Andean mountains, b) animals born at sea level and subjected to a stimulated high altitude postnatally, c) animals born and kept at sea level. The number ...
Carle B N - - 1981
A method is described for demonstrating myocardial necrosis by changes in the autofluorescence of routine hematoxylin and eosin or hematoxylin and eosin-phloxine stained sections using a standard microscope with an epifluorescence attachment. Regions of necrosis fluoresce with a brilliant yellow color clearly distinguishable from the dull olive-green to red-brown fluorescence ...
Seybold V - - 1981
The indirect immunofluorescence technique was used to examine the pharmacology associated with reserpine-induced alterations in vasopressin and neurophysin (VP/NP) immunoreactivity in the external layer of the median eminence in the rat. Twenty-four hours after injection of reserpine, a selective, marked depletion of VP/NP immunoreactivity from the external layer is apparent. ...
Parry G J - - 1981
Despite the clinical importance of ischemia in the pathogenesis of many human neuropathies, little is known about the effect of circulatory compromise on the structure of peripheral nerves. This results in part from the lack of an entirely satisfactory model in which to study ischemic neuropathy. We therefore injected arachidonic ...
Leprán I - - 1981
Four non-steroid anti-inflammatory drugs, sulfinpyrazone, acetylsalicylic acid, sodium salicylate and indomethacin were tested in the acute phase of experimental myocardial infarction in conscious rats. A single oral dose was administered, then 1 h later the occlusion of the left anterior descending coronary artery was made by using a previously implanted ...
Lau V K - - 1981
Cardiac trauma can be experimentally produced by blunt impulsive impact over the cardiac apex in the anesthetized canine. A gradation of myocardial injury, including transient arrhythmia, contusion, and lethal ventricular fibrillation, can be produced by varying the power of the charge in a modified captive bolt pistol. Ballistics experiments were ...
Vizda J - - 1981
A survey is presented of research results of pyrophosphate myocardial scanning in 130 dogs and 150 patients with various myocardial lesions. The results of experiments in animals were immediately applied in clinical practice. The results showed that acute transmural myocardial lesions yielded practically in all instances positive scintigraphic findings. The ...
Willerson J T - - 1980
Alterations in cell and subcellular membrane integrity occur during evolving ischemic myocardial injury. We tested the hypothesis that an antibody against human liver mitochondria [anti-mitochondrial antibody developing in a patient with primary biliary cirrhosis] could identify altered cell membrane integrity in experimental canine myocardial infarcts. The proximal left anterior descending ...
Laky D - - 1980
The dynamics of morphologic and biochemical lesions of the myocardial fiber during the first ten days after an experimental myocardial infarction showed an unequal evolution of the lesional picture in the ischaemic area, the intervention of lysosomal hydrolases and the reactions of inflammatory fibrocollagen substitution. Morphologic aspects in the areas ...
Abe T - - 1980
The most important and effective factor for myocardial protection during cardiac operation is to keep the myocardium at as low a temperature as possible. The ideal temperature is around 15 degrees C. A thumbtack type of needle thermistor has been developed and used clinically and experimentally during myocardial protection. This ...
Czarnecki C M - - 1980
Furazolidone (FZ) at 700 ppm was added to feed mixtures fed turkey poults two weeks posthatching to induce experimental cardiomyopathy. Poults in the control pen received the same ration but without FZ. From ECG data obtained at weekly intervals, poults were selected for sacrifice at 3, 4, and 5 weeks ...
Adams S B - - 1980
Cytologic examination of serial peritoneal fluid samples of nine experimental ponies was performed during a 72 hour period following laparotomy. Six of the ponies had jejunal infarction induced by occlusion of the corresponding vasculature. Cytologic examination was also performed on the peritoneal fluid of a series of horses with naturally ...
Reimer K A - - 1980
Because patient prognosis is related in part to infarct size, therapies that could limit infarct size should be beneficial. The development of such therapies has been hampered by the lack of proven techniques to measure infarct size or to assess the effect of therapy in living patients. In addition, the ...
Reeves W C - - 1980
The ability of dexamethasone (DEX) to reduce the severity of the late stage of radiation-induced heart disease (RIHD) was assessed in 25 New Zealand white rabbits. Ten rabbits served as unirradiated controls (CONT). In Group A, seven rabbits received intravenous DEX prior to irradiation and every 24 hours for three ...
Zanon P L - - 1980
The ventricular myocardium of CD1 mice given a single high dose (LD50) of daunorubicin (DNR) or its derivative, 4-demethoxydaunorubicin (4DD), was studied under the electron microscope. Severe degenerative alterations were observed, but only in the mitochondria in myocardial tissue samples taken 3 and 7 days after treatment. This suggests that ...
Helmius G - - 1980
An experimental method for induction of myocardial infarction in sheep is described. This leads to local infarction without arteriographically demonstrable lesions in the coronary arteries. A 0.95 mm thick thermosonde is introduced into a coronary artery through a catheter. The tip of the thermosonde is heated to 45-65 degrees C ...
Houck J C - - 1979
Both crude and highly purified testicular hyaluronidase preparations have been shown to contain a component which increases the permeability of the microcirculation in rat skin. This permeability activity had an isoelectric point of 7.4 while hyaluronidase was 9.4. It also could be separated from hyaluronidase by acrylamide gel electrophoresis. The ...
Dewanjee M K - - 1979
The pharmacodynamics of several tin compounds were studied in healthy rabbits, rabbits with myocardial infarcts, and isolated myocardial tissue. The results showed that tin chelates of pyrophosphate, HEDP, DTPA, and glucoheptonate are very unstable in vivo, giving rise to free stannous ions. These ions localize mainly in bone, with the ...
Derias N W - - 1979
Wavy myocardial fibres were found in about half each of a series of 28 normal and 31 infarcted human hearts, as well as in the normal heart of an infant. Such fibres were also seen in rather more than half of a series of normal rat hearts. Thus, the wavy ...
Maggs P R - - 1979
The understanding of left ventricular failure and cardiogenic shock after myocardial infarction has been facilitated by a two-component model proposed by Swan et al. which views the left ventricle as consisting of a clearly defined infarcted portion and a normally functioning remainder. Although appealing, this model is difficult to substantiate ...
Dor X - - 1979
An experimental study on the heart of the chick embryo demonstrates that the atrio-ventricular canal does not migrate towards the right, but that it is the inter-ampullar ring which almost completely migrates to the left. Consequently: 1. absence of migration of the interampullar ring will be responsible for the development ...
Anderson K R - - 1979
Experimental cardiac infarction produced in dogs by coronary artery ligation has been used to investigate the value of macroscopic histochemical enzyme loss in the diagnosis of myocardial infarction at post-mortem. Creative phosphokinase and non-specific dehydrogenase methods gave the best results but became positive only 5-6 hr after infarction. It is ...
Thompson P L - - 1979
Limitation of myocardial injury after coronary occlusion is an exciting, recently recognised, but as yet unconfirmed, possibility in the treatment of myocardial infarction. Review of the experimental basis for the concept indicates that although manipulation of the ST segment of the electrocardiogram is not sufficient proof that myocardial necrosis can ...
Barts M P - - 1979
In 59 sexually mature male chinchilla rabbits, and in control sham-operated animals, there were compared the indicators characterizing the functional state of the heart and the levels of catecholamines and of SH groups in experimental myocardial infarction induced by ligating the descending branch of the left coronary artery. Phasic shifts ...
Eldevik O P - - 1978
The effect of hydration on the incidence of complications from myelography with aqueous media was studied. Myelography was performed with methylglucamine iocarmate in dehydrated and vigorously hydrated monkeys. The incidence of seizures and the severity of arachnoiditis were significantly greater in the dehydrated animals. The authors suggest that patients be ...
Heng M K - - 1978
The effect of glucose-insulin-potassium (GIK) infusions was studied in 45 dogs after left anterior descending coronary artery ligation. GIK caused a modest increase in lactate concentration in small veins draining the infarct but did not affect glucose uptake. No effect on creatine kinase activity in the infarct was seen from ...
Higgins C B - - 1978
The concentration of iodine within infarcted and normal myocardium after intravenous administration of contrast material was determined by fluorescence excitation analysis in seven dogs at 48 hours after coronary arterial ligation. The iodine concentration of infarcted myocardial tissue was several times greater than normal myocardium after administration of meglumine/sodium diatrizoate, ...
Laky D - - 1978
The biology of the myocardial fiber was studied under experimental conditions similar to angina and the premonitory syndrome of myocardial infarction. The morphophysiologic data obtained particularly concerning the mitochondria demonstrated that affection of the myocardium by progressive ischaemia induced less severe lesions than the abrupt onset of ischaemia, also lowering ...
Bickford A A - - 1978
Gross and histopathologic lesions were studied in 10 Broad-Breasted White turkeys with acute erysipelas induced experimentally. The gross pathologic features of the disease conformed very closely with descriptions in the literature (7). Histopathologic evaluation was concentrated on the inoculation site (skin), proventriculus, ileocecal area of the intestine, liver, spleen, kidney, ...
Nelson C V - - 1978
Vector dipole moments were measured on young pigs before and one week after ligation of the left anterior descending coronary artery. Vectors were obtained for the three peaks of vector spatial magnitude, M. Preoperative, postoperative, and difference vectors were measured for each peak. If excitation is normal except through the ...
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