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Rommel John J JJ Division of Cardiology, Department of Medicine, The University of North Carolina at Chapel Hill, 160 Dental Circle, 6th Floor Burnett-Womack Building, Chapel Hill, NC 27599-7075, - - 2014
Left ventricular assist devices (LVADs) are an increasingly common treatment for end-stage systolic heart failure. However, there are limited data on how to best treat patients pharmacologically after LVAD implantation, resulting in uncertainty about which heart failure medications provide the most benefit. Still, some evidence exists that certain medical therapies ...
Vazir Ali A Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust, NIHR Cardiovascular Biomedical Research Unit and Institute of Cardiovascular Medicine and Sciences (ICMS), National Heart and Lung Institute (NHLI), Imperial College London, London, - - 2014
The management of heart failure with preserved ejection fraction (HFpEF) is challenging and requires an accurate diagnosis. Although currently there is no convincing therapy that prolongs survival in patients with HFpEF, treatment of fluid retention and of comorbidities, such as hypertension, myocardial ischemia, and atrial fibrillation, may improve symptoms and ...
D'Elia Emilia E Cardiovascular Department, Papa Giovanni XXIII Hospital, Piazza OMS 1, Bergamo 24127, Italy; University of Pavia, Piazzale Golgi 1, Pavia 27100, - - 2014
Mineralocorticoid receptor antagonists (MRAs) have become mandated therapy in patients with reduced ejection fraction (systolic) heart failure (HF) across all symptom classes. These agents should also be prescribed in the early post-myocardial infarction setting in those with reduced ejection fraction and either HF symptoms or diabetes. This article explores the ...
Ibebuogu Uzoma N UN At the University of Tennessee Health Science Center in Memphis, Uzoma N. Ibebuogu is an assistant professor and Rami N. Khouzam is an associate professor. At Georgia Regents University in Augusta, Gyanendra Sharma and John W. Thornton practice in the Division of Cardiology, Roshanak Robati practices in the School of Medicine, and David Silverman practices in the Department of Medicine. The authors have disclosed no potential conflicts of interest, financial or - - 2014
Patent foramen ovale (PFO) is a congenital heart defect that may first be diagnosed in adulthood and has a prevalence of 25% to 30%. Although many patients with PFO are asymptomatic and do not require treatment, paradoxical embolism can cause stroke or myocardial infarction. The authors report an unusual case ...
Pison Laurent L Department of Cardiology, Maastricht University Medical Centre, PO Box 5800, Maastricht, the Netherlands - - 2014
The purpose of this European Heart Rhythm Association (EHRA) survey was to explore the work-up and management of lone atrial fibrillation (AF) among the European centres. Thirty-two European centres, all members of the EHRA electrophysiology (EP) research network, responded to this survey and completed the list of questions. The prevalence ...
Schmidt Tobias T ASKLEPIOS Klinik St. Georg Hospital, Division of Cardiology, Lohmühlenstrasse 5, 20099, Hamburg, - - 2014
The Parachute(®) Ventricular Partitioning Device offers an additional strategy for heart failure patients with exclusion of the infarcted wall to decrease left ventricular volumes, myocardial work, and wall stress. The aim of the present study was to evaluate if Parachute implantation might influence acute haemodynamic and functional performance in patients ...
Farber Nicholas J - - 2014
CMR is considered the 'gold standard' for non-invasive LV and RV mass quantitation. This information is solely based on gradient-recalled echo (GRE) sequences while contrast dependent on intrinsic T1/T2 characteristics potentially offers superior image contrast between blood and myocardium. This study aims, for the first time in humans, to validate ...
Costello John P JP Division of Cardiovascular Surgery, Children's National Health System, Washington, DC, USA The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System, Washington, DC, - - 2014
The development of acquired von Willebrand syndrome (AVWS) after placement of a pulsatile-flow left ventricular assist device (LVAD) is rare and only recently recognized. We report the case of a young infant who was diagnosed with ventricular assist device (VAD)-related AVWS following implantation of a Berlin Heart EXCOR Pediatric Ventricular ...
Karani Kunal B KB The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, - - 2014
The hybrid stage I procedure has emerged as a less-invasive alternative to the standard surgical Norwood procedure in the palliation of high-risk hypoplastic left heart syndrome and variants. This approach may also benefit patients requiring complex neonatal repair who have significant anatomic and/or perioperative risk factors that either prevent or ...
Hastings Ramin S RS Leon H. Charney Division of Cardiology, NYU School of Medicine, New York, NY, USA - - 2014
Coronary artery embolism is an uncommon cause of acute myocardial infarction (MI). We present a patient with pulmonary atresia and severe right heart hypoplasia who underwent a lateral tunnel Fontan procedure in childhood and presented with an acute ST-segment elevation MI at 19 years of age. In addition to the ...
Ozyilmaz Isa I Department of Pediatric Cardiology, Mehmet Akif Ersoy Cardiovascular Research and Training Hospital, Istanbul, - - 2014
A 2.5-month-old female patient presented for closure of a ventricular septal defect (VSD). Transthoracic echocardiography showed a large muscular ventricular septal defect. After perventricular closure of the defect was performed with an Amplatzer muscular VSD occluder, peroperative transesophageal echocardiography revealed that the device had been implanted in the wrong area ...
de Haan S S Department of Cardiology and Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, De Boelelaan 1118, 1081, HV, Amsterdam, the Netherlands, - - 2014
Implantable cardioverter defibrillators (ICD) and cardiac resynchronisation therapy (CRT) have substantially improved the survival of patients with cardiomyopathy. Eligibility for this therapy requires a left ventricular ejection fraction (LVEF) <35 %. This is largely based on studies using echocardiography. Cardiac magnetic resonance imaging (CMR) is increasingly utilised for LVEF assessment, but ...
Ootani Katsuki K Department of Pediatrics, School of Medicine, Hirosaki University, Hirosaki, - - 2014
Described herein is the case of a rare combination of congenital left ventricular (LV) aneurysm and left ventricular non-compaction (LVNC) in a newborn. The patient developed refractory heart failure soon after birth and died at 5 months of age. The etiology of both congenital LV aneurysm and LVNC seems to ...
Huang Ben-Shian BS National Yang-Ming University Hospital, - - 2014
Role of estrogen receptor α (ERα) in the kidney and heart was still uncertain, although Estrogen-ER action is usually thought to function as reno- and possibly cardio-protection, which includes prevention of glomerulosclerosis and podocyte apoptosis in kidney, and atheroprotection by lowering plague formation and against endothelial dysfunction after injury, ischemia ...
Songur C Murat CM Department of Cardiovascular Surgery, Turkey Yuksek Ihtisas Hospital Ankara, - - 2014
We sought to investigate the effects of the angiotension II receptor blocker candesartan on ischemia-reperfusion injury using a cardioplegia arrested isolated rat heart model. Ischemia-reperfusion injury was induced in isolated rat hearts with 40 minutes of global ischemia followed by a 30-minute reperfusion protocol. Throughout the experiment, constant pressure perfusion ...
Wider Joseph J 1 Cardiovascular Research Institute, 2 Department of Physiology, 3 Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, - - 2014
The successful clinical translation of novel therapeutic strategies to attenuate lethal myocardial ischemia-reperfusion injury and limit infarct size has been identified as a major unmet need, and is of particular importance in patients with type-2 diabetes. There is a wealth of preclinical evidence that ischemic conditioning (encompassing the three paradigms ...
Liu Yan - - 2014
This study used gated myocardial perfusion imaging (G-MPI) to assess the clinical value of Xinmailong injection in chronic congestive heart failure (CHF). A total of 102 CHF patients were randomly divided into the control group (n = 51) and the Xinmailong group (n = 51). Patients in the control group ...
Huang Fei Qiong FQ National Heart Centre Singapore, - - 2014
Evaluation of left ventricular (LV) diastolic function is important in clinical echocardiography. The relationship between mitral annular velocities and transmitral inflow velocities provide additional information about LV filling and diastolic function. This study evaluates the relationships of time intervals between peaks E of mitral inflow velocities and E' of mitral ...
Katz Daniel H DH Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, - - 2014
The purpose of this study was to determine the relationship between albuminuria and cardiac structure/function in heart failure with preserved ejection fraction (HFpEF). Albuminuria, a marker of endothelial dysfunction, has been associated with adverse cardiovascular outcomes in HFpEF. However, the relationship between albuminuria and cardiac structure/function in HFpEF has not ...
Bro-Jeppesen John J From the Departments of Cardiology (J.B.-J., C.H., L.K., J.K.) and Cardiothoracic Anesthesia (M.W., M.O.), The Heart Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Anesthesia and Intensive Care, Lund University, Helsingborg Hospital, Helsingborg, Sweden (N.N.); and Departments of Cardiology (D.E.) and Anesthesia and Intensive Care (H.F.), Lund University, Skåne University Hospital, Lund, Sweden. - - 2014
Cardiovascular dysfunction is common after out-of-hospital cardiac arrest as part of the postcardiac arrest syndrome, and hypothermia may pose additional impact on hemodynamics. The aim was to investigate systemic vascular resistance index (SVRI), cardiac index, and myocardial performance at a targeted temperature management of 33°C (TTM33) versus 36°C (TTM36). Single-center ...
Srivatsan Varsha V Department of Cardiology, SRM Medical College Hospital and Research Centre, - - 2014
Heart failure (HF) continues to be an illness of daunting proportions with a four- year mortality touching 50%. Biomarkers for prognosticating patients with heart failure have generated immense interest. Several studies have been conducted on a novel biomarker, galectin-3 to assess its prognostic effect in heart failure populations. However, the ...
Rawat Dhawjbahadur K DK From the Departments of Biochemistry and Molecular Biology (D.K.R., R.G., S.C., S.A.G.), Pharmacology (A.A., I.F.M.), Lung Biology (A.A., I.F.M., S.A.G.), Internal Medicine (I.F.M.), and Pathology (A.G.K.), University of South Alabama, College of Medicine, Mobile; and Department of Physiology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan (M.W., - - 2014
Pulmonary arterial hypertension (PAH) is a debilitating and deadly disease with no known cure. Heart failure is a major comorbidity and a common cause of the premature death of patients with PAH. Increased asymmetrical right ventricular hypertrophy and septal wall thickening compress the left ventricular cavity and elicit diastolic heart ...
Bates Angelina A Olathe Cardiology Services, Olathe Medical Center, Olathe, Kansas, - - 2014
Diastolic heart failure, or heart failure with preserved ejection fraction, is a leading cause of morbidity and mortality. There are no current therapies effective in improving outcomes for these patients. The aim of this article is to review the literature and examine the role of coenzyme Q10 in heart failure ...
Anselmino Matteo M Cardiology Division, Department of Medical Sciences, University of Turin, Turin, - - 2014
-Catheter ablation of atrial fibrillation (AFCA) is an established therapeutic option for rhythm control in symptomatic patients. Its efficacy and safety among patients with left ventricular systolic dysfunction is based on small populations, and data concerning long-term outcome are limited. We performed this meta-analysis to assess safety and long-term outcome ...
Singh Robin Man RM Robin Man Singh, Department of Medicine, University of Louisville, Louisville, KY 40202, United - - 2014
Left ventricular ejection fraction (LVEF) is an important predictor of cardiac outcome and helps in making important diagnostic and therapeutic decisions such as the treatment of different types of congestive heart failure or implantation of devices like cardiac resynchronization therapy-defibrillator. LVEF can be measured by various techniques such as transthoracic ...
Frazier O H OH Department of Cardiopulmonary Transplantation and the Center for Cardiac Support, Texas Heart Institute, Houston, Texas. Electronic address: - - 2014
The potential for myocardial reconditioning and device explantation after long-term continuous-flow left ventricular assist device (LVAD) support presents an opportunity to delay or avoid transplantation in select patients. Thirty of 657 patients with end-stage heart failure supported with continuous-flow LVADs were assessed for device explantation. Each patient underwent an individualized ...
Pinchuk T V TV N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia, - - 2014
Proinflammatory markers were evaluated in patients with chronic heart failure of ischemic origin and essential hypertension with preserved left-ventricular ejection fraction before and after a 6-month course of simvastatin therapy (20 mg/day). The study was carried out in 125 patients with diastolic dysfunction manifested as impaired relaxation and pseudonormalization. The ...
Mamalyga M L ML Department of Anatomy and Physiology of Humans and Animals, Moscow State Pedagogical University, Moscow, Russia, - - 2014
Monitoring of the heart status during increasing stress-induced load allowed us to evaluate heart function after treatment of absence epilepsy with anticonvulsants of various types of action. Functional load against the background of treatment with lamotrigine or convulex had different effects on the dynamics of heart rate variability, hemodynamic parameters ...
Vardeny Orly O Department of Pharmacy, University of Wisconsin School of Pharmacy, Madison, Wisconsin. Electronic address: - - 2014
Neprilysin is an enzyme that contributes to the breakdown of the biologically active natriuretic peptides and several other vasoactive compounds. Inhibiting neprilysin has been a therapeutic target for several compounds that have been tested in cardiovascular disease, including ecadotril, candoxatril, omapatrilat, and LCZ696. Although ecadotril, candoxatril, and omapatrilat were initially ...
Shah Syed Raza SR Dow University of Health Sciences (DUHS), Karachi, Pakistan, - - 2014
The burden of noncommunicable diseases (NCDs) is emerging as a major public health challenge for the world. NCDs are projected to account for around 75 % of global mortality by the year 2020. The most common and problematic of all noncommunicable conditions is heart disease. As such, the weight of ...
Singh Mahipal M Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN - - 2014
Heart failure represents a major cause of morbidity and mortality in the western society. Cardiac myocyte loss due to apoptosis plays a significant role in the progression of heart failure. The extracellular matrix (ECM) maintains the structural integrity of the heart and allows the transmission of electrical and mechanical signals ...
Soeki Takeshi T Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. Electronic address: - - 2014
Ghrelin is a novel growth hormone (GH)-releasing peptide originally isolated from the stomach. Recently, we have shown that ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction. In the present study, we evaluated the effect of ghrelin on autonomic nerve activity in healthy ...
Morisawa Daisuke D *Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine †Division of Coronary Heart Disease, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, - - 2014
It remains unknown how sildenafil acutely provides hemodynamic alterations in patients with decompensated congestive heart failure. The aim of this study was to investigate whether myocardial and/or hemodynamic conditions affect hemodynamic response to sildenafil in patients with decompensated heart failure. Twenty five consecutive patients with decompensated congestive heart failure were ...
Abnousi Freddy F Stanford University, Stanford, CA. Electronic address: - - 2014
Heart failure with preserved ejection fraction is often thought of as "the other half" of all heart failure. It is similar to heart failure with reduced ejection fraction in incidence, prevalence, morbidity, mortality, and cost, yet there is still not a single therapy - device, pharmaceutical, or otherwise - that ...
Gerede Demet Menekse DM Department of Cardiology, Ankara University School of Medicine, Ankara, - - 2014
Scleroderma is a connective tissue disease characterized by diffuse vascular lesions and fibrosis of the skin and major organs including lungs, kidneys, and heart. When cardiac involvement is clinically evident, it is recognized as a poor prognostic factor. The early detection of cardiac involvement in scleroderma would be desirable both ...
Garza Jennifer L JL Division of Occupational and Environmental Medicine, UConn Health, Farmington, CT, USA, - - 2014
High levels of workplace psychosocial factors have been associated with adverse cardiovascular outcomes, possibly through the pathway of increasing autonomic arousal. The purpose of this study was to investigate whether the workplace psychosocial factors of effort-reward imbalance (ERI) and overcommitment were associated with greater decreases in heart rate variability (HRV) ...
Crucean Adrian A 1Department of Paediatric Cardiac Surgery,Birmingham Children's Hospital,Birmingham,United - - 2014
Although holes, or channels, between the ventricles are the commonest congenital cardiac malformations, there is still no consensus as to how they can best be described and categorised. So as to assess whether it is possible to produce a potentially universally acceptable system, we have analysed the hearts categorised as ...
Moore J P JP Department of Pediatrics, Division of Pediatric Cardiology and the Ahmanson/UCLA Adult Congenital Heart Disease Center - - - 2014
Arrhythmia in the adult congenital heart disease (ACHD) population is recognized as a major source of morbidity and mortality and has contributed to an increasing burden on the health care system over the past several decades. Abnormalities of impulse formation and propagation encountered in this population are distinct from those ...
Agarwal Richa R Division of Cardiology, Department of Medicinea, Department of Cardiothoracic Surgeryb, Cardiovascular Institute, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, - - 2014
Management for continuous flow left ventricular assist device thrombosis often relies on speculation of individual clinical risk factors and integration of indirect evidence for device dysfunction. There are no comprehensive guidelines for treatment of this serious complication, and most of our current knowledge comes from anecdotal experience or observational study. ...
Patel Nikita M NM Department of Biomedical Engineering, Cullen College of Engineering, University of Houston, Houston, TX, - - 2014
Current therapies in left ventricular systolic dysfunction and end stage heart failure include mechanical assist devices and/or transplant. The development of a tissue-engineered integrative platform would present a therapeutic option which overcomes the limitations associated with current treatment modalities. This study provides a foundation for the fabrication and preliminary viability ...
Carrilho-Ferreira Pedro P Lisbon School of Medicine, Lisbon Academic Medical Center, CCUL, Lisbon University, Lisbon, - - 2014
Left ventricular non-compaction (LVNC) is thought to arise from arrest of the normal process of trabecular remodeling or "compaction" that takes place during embryonic life and is characterized by the presence of a two-layered ventricular wall, with a compact epicardial layer and a non-compacted endocardial layer. It is an uncommon ...
Lowalekar Samar K - - 2014
ObjectivesHearts preserved ex vivo at 4°C undergo time-dependent irreversible injury due to extreme hypothermia. Studies using novel organ preservative solution SOMAH, suggest that hearts are optimally `preserved¿ at subnormothermic temperature of 21°C. Present study evaluates relative efficacy of SOMAH `cardioplegia¿ at 4 and 21°C in preservation of optimum heart function ...
Attin Mina M School of Nursing, San Diego State University, 5500 Campanile Drive, San Diego, CA, 92182, USA, - - 2014
Survival after in-hospital cardiac arrest (I-HCA) remains < 30 %. There is very limited literature exploring the electrocardiogram changes prior to I-HCA. The purpose of the study was to determine demographics and electrocardiographic predictors prior to I-HCA. A retrospective study was conducted among 39 cardiovascular subjects who had cardiopulmonary resuscitation from ...
Pleister Adam A Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, - - 2014
The catastrophic consequences for patients in the settings of certain clinical conditions such as acute right ventricular infarction or massive pulmonary embolism with right heart failure illustrate the essential role that the right ventricle plays in sustaining life. With the development of more sophisticated diagnostic imaging technologies at the end ...
Limongelli Giuseppe G Division of Cardiology, Monaldi Hospital, Second University of Naples, Naples, - - 2014
The physiological importance of the right ventricle (RV) has been underestimated over the past years. Finally in the early 1950s through the 1970s, cardiac surgeons recognized the importance of RV function. Since then, the importance of RV function has been recognized in many acquired cardiac heart disease. RV can be ...
Gargiulo Paola P Department of Advanced Biomedical Sciences, Federico II University, Naples, - - 2014
For many years, the right ventricle (RV) has been considered a passive chamber with a relatively insignificant role in the overall functionality of the heart. More recently, the role of performance of RV in the clinical presentation and long-term prognosis of multiple pathological states, such as congenital heart diseases, chronic ...
Fernández-Jiménez Rodrigo R Department of "Atherothrombosis, Imaging and Epidemiology", Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro, 3. 28029, Madrid, - - 2014
Heart attack (myocardial infarction) is a highly prevalent entity worldwide. Widespread implementation of reperfusion strategies has dramatically reduced the mortality associated with infarction. Paradoxically, the mortality reduction has significantly increased the incidence of chronic heart failure (HF). Treatment of HF, once present, represents a huge socioeconomic burden on individuals and ...
Lai Ling L Diabetes and Obesity Research Center, Cardiovascular Pathobiology Program, Sanford-Burnham Medical Research Institute, Orlando, - - 2014
-An unbiased systems approach was utilized to define energy metabolic events that occur during the pathologic cardiac remodeling en route to heart failure. -Combined myocardial transcriptomic and metabolomic profiling were conducted in a well-defined mouse model of heart failure that allows comparative assessment of compensated and decompensated (heart failure) forms ...
Freites Alfonso A Department of Cardiology, University Hospital Fundacion Alcorcon, Madrid, - - 2014
We presented the case of an adult male without structural heart disease, who in the period of 3 years developed apical hypertrophic cardiomyopathy. ECG changes preceded the development of ventricular hypertrophy. We discussed the appearance of ventricular enlargement during adulthood, in some cases of hypertrophic cardiomyopathy (HC), and how the ...
Blechman Ido I Heart Failure Institute and Leviev Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, - - 2014
Improvement in the left ventricular ejection fraction (LVEF) may occur in patients with dilated cardiomyopathy (DCM). There are different implications of persistent versus transient improvement in LVEF among DCM patients receiving contemporary therapy. We studied 188 patients with nonischemic DCM. Persistent improvement in LVEF (PIEF) was defined as LVEF increase ...
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