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Aspelin Peter - - 2006
The aim of the study was to assess the effects of iodinated contrast media on blood components and endothelium based on experimental and clinical studies and to produce clinically relevant guidelines for reducing thrombotic and hematologic complications following the intravascular use of contrast media. A report was drafted after review ...
Wang Jinfeng - - 2006
In this report, we describe a simple and fast method for creating a murine myocardial infarction model and providing a useful and convenient tool for the research in ischemic heart disease. We established acute myocardial infarction in the Kunming-strain mouse within 2 minutes by ligating the left anterior descending coronary ...
Gupta Anuj - - 2006
Myocardial fibrosis has been identified in biopsy specimens from catheterization and valve replacement surgery in patients with severe chronic aortic regurgitation (AR). While characterization of these extracellular matrix (ECM) alterations has been incomplete in humans, fibrosis also has been identified in chronic severe experimentally created AR, in which ECM composition ...
Rodovicius Hiliaras - - 2006
The objective of this study was to examine the acceptor activities of tRNA for amino acids, valine and arginine, and the activities of the corresponding aminoacyl-tRNA synthetases of normal rabbit liver and 6, 12 and 24 h after experimental myocardial ischemia in different seasons of the year. MATERIAL AND METHODS: ...
Zhong Jing-quan - - 2005
Epinephrine (adrenaline) and vasopressin have been by far the most commonly studied vasopressors in experimental cardiac arrest. Despite animal experimental studies suggesting improved outcomes in experimental cardiac arrest, clinical trials of pressor agents have failed to show clear cut benefit from either vasopressin or epinephrine, although few, if any, trials ...
Rakhmatullina F F - - 2005
Experimental myocardial infarction (coronary ligation without drug infusion) reduced heart rate, stroke volume, cardiac output, and blood pressure. Under conditions of blocked NO synthesis, experimental myocardial infarction was accompanied by a transient increase in heart rate, stroke volume, cardiac output, and blood pressure, followed by their decrease throughout the experiment. ...
Hamid Shabaz A - - 2005
During and following acute myocardial infarction, a variety of endogenous mediators are elevated, one of which is adrenomedullin (AM). AM is a multifunctional peptide that has been identified as having a putative beneficial role following an ischemic insult at both systemic and local levels. Classically described as a potent vasodilator, ...
Genlin Xu X Coll. of Med. Instrum., Univ. of Shanghai for Sci. & - - 2005
The compression of the mural coronary artery also exists in the diastole. We make a myocardial bridging simulator and build an experimental model to study the status of the compression. Through the simulative experiment, we make a numerical value simulation which depicts the effect of the myocardial bridge on the ...
Ge Dingfei D Department of Information & Electrical Engineering, Zhejiang University of Science and Technology, Hangzhou 310012, - - 2005
There is a need to develop a criterion to measure the class separability of cardiac data before the decision-making logic is applied. This article explores the use of separability criteria to measure the separability of cardiac data. Then a new separability criterion was presented, which was constructed by combining standard ...
Mueller Nicolas J - - 2004
BACKGROUND: Xenotransplantation using pigs as the source species for organs carries a potential risk for transmission and activation of porcine herpesviruses. Activation of porcine cytomegalovirus (PCMV) in pig-to-baboon xenotransplantation is associated with xenograft injury and possibly an increased incidence of consumptive coagulopathy (CC). METHODS: To further investigate the role of ...
Telgmann Ursula - - 2004
The development of biofilms is determined by the balance of growth and detachment. But while the growth of biofilms is well studied, the influence of growth history and detachment on biofilm development is not. Here we report on laboratory scale experiments where heterotrophic biofilms were grown in a tubular reactor. ...
Salto-Tellez Manuel - - 2004
INTRODUCTION: The laboratory mouse is a powerful tool in cardiovascular research. In this report, we describe a method for a reproducible mouse myocardial infarction model that would allow subsequent comparative and quantitative studies on molecular and pathophysiological variables. METHODS: (A) The distribution of the major coronary arteries including the septal ...
Lukyanov Anatoly N - - 2004
Micelles prepared from polyethyleneglycol/phosphatidyl-ethanolamine conjugates (PEG-PE) with a size of 7-20 nm and zeta-potential of approximately -18 mV were administered i.v. to rabbits with experimental myocardial infarctions. Micelles demonstrated a prolonged circulation in the blood (half-life of 2 h) and accumulated in the infarction zone with efficiency more than 8-fold ...
Moreno José Bitu - - 2004
Recently, we showed that the arterial in-line application of the leukocyte inhibition module (LIM) within the heart-lung machine limits overshooting leukocyte activity and cardiac tissue damage. Moreover, significantly better cardiac function was found in an experimental animal model when LIM was used. In the meantime, the first promising clinical data ...
Azizov V A - - 2003
OBJECTIVE: To study immunohistochemical and electron-microscopic features of secretory cardiomyocytes in experimental myocardial infarction (MI). METHODS: Totally 15 hearts of dogs with experimental MI were studied. For electron-microscopic study materials were collected from left atrium, and its several parts (appendix, lateral and frontal walls). For immunohistochemical analysis of atrial natriuretic ...
Yakobson G S - - 2003
We compared the results of clinical and experimental studies of endocrine parameters in patients with myocardial infarction and arterial hypertension and NISAG rats with hereditary stress-induced arterial hypertension during experimental myocardial infarction. Changes in the content of corticosterone, aldosterone, insulin, triiodothyronine, and thyroxin were similar in animals and patients with ...
Brock William J - - 2003
An increased sensitivity of the heart to endogenous epinephrine (adrenaline), a phenomenon referred to as cardiac sensitization, has long been recognized as a risk during exposure to hydrocarbons, principally halogenated hydrocarbons. Cardiac sensitization, which can result in serious arrhythmia and death, requires a certain critical blood level of both the ...
Verwoerd-Verhoef Henriette L - - 2003
OBJECTIVE: To assess the impact of lateral nasal wall surgery on sinonasal growth METHODS: Twenty young New Zealand White rabbits, 6 weeks of age, were included in this experimental study. Surgery was performed on two groups of ten animals each (series I and II). Entrance to the left nasal cavity ...
Kang Y James - - 2003
Interest in cardiotoxicity has dramatically increased during the past two years, leading to exciting progress in our understanding of the field. Both clinical and experimental animal studies have emphasized the role of cardiotoxicity in myocardial pathogenesis. Exploration of the cardiotoxicity of air pollution and highly active antiretroviral therapy (HAART) through ...
Sun Chia-Wei - - 2002
Time-resolved Stokes vectors of transmitted optical signals were measured to differentiate normal and stunned myocardium tissues. The corresponding Mueller matrices were calculated based on the Stokes-Mueller formalism. Our experimental results indicated that the time-resolved Mueller matrices could provide information about myocardial architectural alteration in stunned myocardium. Thus, the Stokes-Mueller measurement ...
Tiemann Klaus - - 2002
Myocardial contrast echocardiography (MCE) has become a major field of clinical research in echocardiography in the last decade. The introduction of new contrast agents was accompanied by a large variety of new contrast specific imaging techniques. Recent experimental and clinical studies demonstrate that MCE is now ready for clinical applications. ...
Bassingthwaighte James B - - 2002
Physical systems, from galactic clusters to diffusing molecules, often show fractal behavior. Likewise, living systems might often be well described by fractal algorithms. Such fractal descriptions in space and time imply that there is order in chaos, or put the other way around, chaotic dynamical systems in biology are more ...
Redington Andrew N - - 2002
This article describes the importance of the right ventricle in both the normal circulation, and in the abnormal milieu of previously palliated or corrected congenital heart disease. The latter group represents natural models of abnormal right ventricular loading that do not exist in any other experimental arena, and their study ...
Liu Jian-Xun - - 2002
AIM: To study the effects of recombinant staphylokinase (r-Sak) on coronary thrombosis, cardiac ischemia, and myocardial infarction in Chinese experimental miniature swine. METHODS: Endarterium was injuried and coronary thrombi were formed gradually through direct electrical stimulation on the coronary artery of Chinese experimental miniature swine. Effects of r-Sak in vitro ...
Spieckermann P G - - 2002
Due to the numerous chapters discussing the history of this society, substantial aspects of cardiovascular research are covered to a great extent. Therefore it is extraordinarily difficult to find a convincing classification for the field of "Experimental Cardiology". What remains, if physiology, heart surgery, coronary heart disease, diagnostic imaging, heart ...
Spodick David H - - 2002
Diagnosis and treatment for the heart and virtually all its structures is becoming available via the pericardium. With or without pericardial effusion (formerly necessary for safe access), instruments that can enter the noneffusive pericardium are available and thoroughly tested experimentally, with human trials currently under way. Successful therapy includes antiarrhythmic, ...
Baroldi G - - 2001
Pathological contraction bands affecting myocardial cells are observed in many different human conditions and in different experimental models. Their morphology was defined long ago but we need to understand the pathogenesis and functional meaning. A distinction between different histological forms of contraction bands and their quantification in a large spectrum ...
Goumghar M D - - 2001
Experimental infections of two susceptible French populations of Lymnaea truncatula (Courcelles and Saint Ours) with an allopatric (Fès, Morocco) or a semi-sympatric (Limoges, France) isolate of Fasciola hepatica miracidia were performed to determine the effect of allopatric miracidia on redial and cercarial production. In both populations, cercarial release was significantly ...
Bailer A J - - 2001
We have been challenged by Peter Chapman to consider the implication of hormesis for both ecotoxicology and ecological risk assessment. A consideration of his proposal led to the following observations and comments. I echo his comments related to the need for experimental designs and statistical tools that accommodate and address ...
Herrmann J - - 2001
OBJECTIVE: Experimental hypercholesterolemia is associated with vasa vasorum neovascularization, unknown to occur before or after initial lesion formation. Thus, this study was performed to determine the temporal course of neovascularization of coronary vasa vasorum in relation to endothelial dysfunction, a hallmark of early atherosclerosis. METHODS: Female domestic pigs were fed ...
Gandini C - - 2001
Cardiac dysfunction including arrhythmias and myocardial ischemia have often been reported in carbon monoxide poisoning; scattered punctiform hemorrhages throughout the heart have been documented in autopsy samples. An appropriate diagnostic approach is crucial to assess carbon monoxide cardiac damage. This evaluation may be confounded by several factors, including the absence ...
Kostin Y V - - 2000
High antiarrhythmic activity of a new Russian antiarrhythmic drug quaternidine in ventricular arrhythmia was studied in 96 coronary patients by Holter monitoring, bicycle ergometry, and echocardiography. The drug had a positive impact on local kinetics in left-ventricular ischemic myocardium and some parameters of bicycle exercise test. The preparation possesses no ...
Leibrandt P N - - 2000
BACKGROUND: The transmission of 12-lead electrocardiograms from remote locations to hand-held computers of cardiologists is now possible with the development of wireless technology and computer software. This investigation determined whether the cardiologist's decisions regarding reperfusion therapy for patients with symptoms suggestive of an acute myocardial infarction are the same when ...
Panchal A R - - 2000
The goal of this study was to measure flux through pyruvate carboxylation and decarboxylation in the heart in vivo. These rates were measured in the anterior wall of normal anesthetized swine hearts by infusing [U-(13)C(3)]lactate and/or [U-(13)C(3)] pyruvate into the left anterior descending (LAD) coronary artery. After 1 h, the ...
Armbruster P - - 2000
Understanding the consequences of inbreeding has important implications for a wide variety of topics in population biology. However, most studies quantifying the effects of inbreeding are performed under artificial farm, greenhouse, laboratory or zoo conditions. Although several authors have argued that the deleterious effects of inbreeding (inbreeding depression) are likely ...
Tamaki N - - 2000
Nuclear medicine has progressed in conjunction with the recent growth of molecular medicine. Myocardial energy metabolism has long been investigated in experimental models with the use of Langendorff's method or coronary sinus blood sampling. However, the introduction of a variety of radiopharmaceutical agents has now made possible easy visualization of ...
Ytrehus K - - 2000
Results obtained by experimental studies of the ischemic heart have been of tremendous importance for the understanding of physiology, biochemistry and lately also the molecular genetics of the heart. Experimental models in use for the study of the ischemic heart involve studies on the integrated organism, experiments with isolated hearts ...
Vazquez-Jimenez J F - - 2000
OBJECTIVE: Cardiac lymph is the most direct medium for analyzing metabological changes in the myocardial cell. Currently, dogs are the animals used for investigation of myocardial lymphatic function. However, questions arise when comparing and interpreting the human system to the experimental model, since the dog coronary anatomy is different from ...
Leabu M. V. - - 2000
Peroxidatic activity in heart effluent was defined as a new biochemical parameter for the experimental study of myocardial ischemia. The peroxidatic reaction was determined by dot blot analysis with 3,3'-diaminobenzidine as hydrogen donor. After ischemia, the level of peroxidatic activity in heart effluent was 2-3 times higher than before. The ...
Spalding M B - - 2000
An experimental model of right heart failure was developed to determine the effects of fluid loading and aminophylline on right heart function. We hypothesised that aminophylline would specifically improve right heart function through a decrease in pulmonary vascular resistance and, possibly, an increase in cardiac contractility. Right heart infarct was ...
Konstantinov I E - - 2000
Sergei S. Brukhonenko designed and constructed one of the earliest heart-lung machines. He was the first to experimentally perform a total body perfusion with the heart of the animal isolated from the circulation. His work paved the way to the first experimental operations on heart valves. Although Brukhoneko's pioneering contributions ...
Apstein C S - - 2000
Early clinical trials of glucose-insulin-potassium for acute myocardial infarction were inconclusive. However, several recent placebo-controlled, prospective, randomized clinical trials of glucose-insulin-potassium for acute myocardial infarction or metabolic support during and after cardiac surgery have demonstrated its efficacy. These clinical results are supported by experimental studies that have shown a strong ...
Lazda E J - - 2000
The aims of this study were to determine whether immunohistochemical staining for C9 can demonstrate myocardial necrosis in the fetus and neonate. Hearts from cases of stillbirth or neonatal death with confirmed myocardial necrosis (in neonates) or with ischemic lesions outside the heart (in neonates and stillborns) were stained immunohistochemically ...
Tazawa H - - 1999
Avian embryos develop within a hard eggshell which permits the measurement of heart rate while maintaining an adequate gas exchange through the chorioallantoic membrane. Heart rate has been determined from cardiogenic signals detected either noninvasively, semi-invasively or invasively with various transducers. Firstly, we reviewed these previously-developed methods and experimental results ...
Matsusaka T - - 1999
Accumulating data show that excess of angiotensin II (Ang II) is involved in cardiac fibrosis. Many experimental studies suggested that Ang II induces cardiac fibrosis not by its blood pressure-raising action, but rather by a direct action on the heart. However, it has been difficult to distinguish the local and ...
White J M - - 1999
BACKGROUND: Acute myocardial infarction places additional demands on an already compromised myocardium. Relaxing music can induce a relaxation response, thereby reversing the deleterious effects of the stress response. OBJECTIVES: To compare the effects of relaxing music; quiet, uninterrupted rest; and "treatment as usual" on anxiety levels and physiological indicators of ...
Pneumaticos S G - - 1999
This experimental animal study compared the healing patterns between open and closed treatments of Achilles tendon tenotomies. Twenty-four male New Zealand rabbits underwent tenotomy of the left Achilles tendon and were randomized into two groups, treated with either open surgical repair or closed management. After the death of the animal, ...
Katwa L C - - 1999
Biosynthesis of endothelin-1 (ET-1), the most potent endogenous vasoconstrictor yet identified, is increased following myocardial infarction (MI) in man. Pathological events which occur in the connective tissues of the equine hoof during laminitis are similar in some respects, to changes occurring in the myocardial connective tissues following MI in man. ...
Santos A C - - 1998
ABSTRACT. The aim of the present study was to investigate the lymphatic cardiac circulation in an experimental model of ischemia plus reperfusion in mongrel dogs (Canis familiaris L). As radiotracer we used 0.2-0.25 ml (111 MBq) of 99mTc-Re2S7 colloid (+/-10 microm), injected subcapsullary below the second diagonal of the descending ...
Weems C F - - 1998
This experiment used the integration of a multi-element design with a second baseline to isolate the effect of biofeedback on the control of a target response, heart rate. The results of the experiment indicate that contingent visual heart rate feedback was instrumental in specifically facilitating the control of heart rate ...
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