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Lowalekar Samar K - - 2014
ObjectivesHearts preserved ex vivo at 4°C undergo time-dependent irreversible injury due to extreme hypothermia. Studies using novel organ preservative solution SOMAH, suggest that hearts are optimally `preserved¿ at subnormothermic temperature of 21°C. Present study evaluates relative efficacy of SOMAH `cardioplegia¿ at 4 and 21°C in preservation of optimum heart function ...
Attin Mina M School of Nursing, San Diego State University, 5500 Campanile Drive, San Diego, CA, 92182, USA, - - 2014
Survival after in-hospital cardiac arrest (I-HCA) remains < 30 %. There is very limited literature exploring the electrocardiogram changes prior to I-HCA. The purpose of the study was to determine demographics and electrocardiographic predictors prior to I-HCA. A retrospective study was conducted among 39 cardiovascular subjects who had cardiopulmonary resuscitation from ...
Pleister Adam A Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, - - 2014
The catastrophic consequences for patients in the settings of certain clinical conditions such as acute right ventricular infarction or massive pulmonary embolism with right heart failure illustrate the essential role that the right ventricle plays in sustaining life. With the development of more sophisticated diagnostic imaging technologies at the end ...
Limongelli Giuseppe G Division of Cardiology, Monaldi Hospital, Second University of Naples, Naples, - - 2014
The physiological importance of the right ventricle (RV) has been underestimated over the past years. Finally in the early 1950s through the 1970s, cardiac surgeons recognized the importance of RV function. Since then, the importance of RV function has been recognized in many acquired cardiac heart disease. RV can be ...
Gargiulo Paola P Department of Advanced Biomedical Sciences, Federico II University, Naples, - - 2014
For many years, the right ventricle (RV) has been considered a passive chamber with a relatively insignificant role in the overall functionality of the heart. More recently, the role of performance of RV in the clinical presentation and long-term prognosis of multiple pathological states, such as congenital heart diseases, chronic ...
Fernández-Jiménez Rodrigo R Department of "Atherothrombosis, Imaging and Epidemiology", Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro, 3. 28029, Madrid, - - 2014
Heart attack (myocardial infarction) is a highly prevalent entity worldwide. Widespread implementation of reperfusion strategies has dramatically reduced the mortality associated with infarction. Paradoxically, the mortality reduction has significantly increased the incidence of chronic heart failure (HF). Treatment of HF, once present, represents a huge socioeconomic burden on individuals and ...
Lai Ling L Diabetes and Obesity Research Center, Cardiovascular Pathobiology Program, Sanford-Burnham Medical Research Institute, Orlando, - - 2014
-An unbiased systems approach was utilized to define energy metabolic events that occur during the pathologic cardiac remodeling en route to heart failure. -Combined myocardial transcriptomic and metabolomic profiling were conducted in a well-defined mouse model of heart failure that allows comparative assessment of compensated and decompensated (heart failure) forms ...
Freites Alfonso A Department of Cardiology, University Hospital Fundacion Alcorcon, Madrid, - - 2014
We presented the case of an adult male without structural heart disease, who in the period of 3 years developed apical hypertrophic cardiomyopathy. ECG changes preceded the development of ventricular hypertrophy. We discussed the appearance of ventricular enlargement during adulthood, in some cases of hypertrophic cardiomyopathy (HC), and how the ...
Blechman Ido I Heart Failure Institute and Leviev Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, - - 2014
Improvement in the left ventricular ejection fraction (LVEF) may occur in patients with dilated cardiomyopathy (DCM). There are different implications of persistent versus transient improvement in LVEF among DCM patients receiving contemporary therapy. We studied 188 patients with nonischemic DCM. Persistent improvement in LVEF (PIEF) was defined as LVEF increase ...
Nearing Bruce D BD Division of Cardiovascular Medicine,  Department of Medicine,  Beth Israel Deaconess Medical Center,  Harvard-Thorndike Electrophysiology Institute, Harvard Medical School, Boston, - - 2014
Contemporary electrocardiographic (ECG) markers including ventricular ectopy and arrhythmias have not proved reliable in risk assessment for life-threatening arrhythmias. We developed the "Multilead ECG Template-Derived Residua" approach to remove intrinsic morphologic differences and allow calculation of pathologic ECG heterogeneities among spatially separated leads. Prediction by R-wave and T-wave heterogeneity (RWH, ...
McConnell Patrick I PI The Department of Cardiothoracic Surgery and Research Institute, Nationwide Children's Hospital1; Department of Surgery, The Ohio State University Wexner Medical Center2; Qtest Laboratories 3, Columbus, Ohio and the Department of Surgery and Wright State University, Dayton Ohio - - 2014
Direct mechanical ventricular actuation (DMVA) exerts direct cardiac compression/decompression and does not require blood contact. The safety and effects of DMVA support in chronically dysfunctional beating hearts in vivo have not been established. This study evaluated hemodynamics and load-independent systolic/diastolic cardiac function before/after acute support (2 hours) using DMVA in ...
Mada Razvan O - - 2014
Echocardiography is the standard method for assessing myocardial function in patients with ischemic heart disease. The acquisition and interpretation of echocardiographic images, however, remains a highly specialized task which often relies entirely on the subjective visual assessment of the reader and requires therefore, particular training and expertise. Myocardial deformation imaging ...
Moss Travis J TJ Cardiovascular Division, Department of Internal Medicine, and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA 22908, USA. Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, - - 2014
The original observation that reduced heart rate variability (HRV) confers poor prognosis after myocardial infarction has been followed by many studies of heart rate dynamics. We tested the hypothesis that an entropy-based local dynamics measure gave prognostic information in ambulatory patients undergoing 24-h electrocardiography. In this context, entropy is the ...
Slaughter Mark S MS 1Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY 40202 2Department of Bioengineering, University of Louisville, Louisville, KY 40202 3CorMatrix, Roswell - - 2014
Biomaterials with direct intramyocardial injection devices have been developed and are being investigated as a potential cardiac regenerative therapy for end-stage ischemic heart failure (IHF). Decellularized extracellular matrix (ECM) has been shown to improve cardiac function and attenuate or reverse pathologic remodeling cascades. CorMatrix Cardiovascular, Inc. has developed a porcine ...
Grosman-Rimon Liza L * Faculty of Kinesiology and Physical Education, University of Toronto † Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network ‡ Division of Nephrology, University Health Network, University of - - 2014
Although the newer continuous flow left ventricular assist devices (CF-LVADs) provide clinical advantages over the pulsatile pumps, the effects of low pulsatility on inflammation are incompletely understood. The objective of our study was to examine the levels of inflammatory mediators in CF-LVAD recipients compared to both healthy controls and to ...
Gregori Mario M aCardiology, Department of Clinical and Molecular Medicine, University of Rome 'Sapienza' bIRCCS Neuromed, Pozzilli, Italy cCardiology Unit, Department of Medicine, Karolinska Institute, Stockholm, - - 2014
Right ventricular dysfunction (RVD) is associated with poor cardiovascular outcome. The renin-angiotensin-aldosterone system is involved in alterations of the left ventricular geometry and function. Detrimental effects of the renin-angiotensin-aldosterone system on the right ventricular function are being postulated, but data supporting this assumption are still lacking. The aim of the ...
Bonadei Ivano I Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Study of Brescia, - - 2014
Although the introduction of novel medical and invasive therapies in recent years has led to a significant reduction in mortality from heart failure, the same cannot be said for mortality due to cardiogenic shock. Drug therapy with inotropic agents and catecholamines has the disadvantage of causing increased myocardial oxygen consumption ...
Yoshioka Daisuke D Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan - - 2014
We report the successful longest biventricular support using dual Jarvik 2000 biventricular assist device (BVAD; Jarvik Heart, Inc., New York, NY, USA) as a bridge to transplant. A 27-year old woman with arrhythmogenic right ventricular cardiomyopathy underwent implantation of two Jarvik 2000s as a left ventricular assist device and right ...
Vaduganathan Muthiah M Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, - - 2014
Heart failure (HF) accounts for over 1 million primary hospitalizations in the USA each year and carries a tremendous burden on costs and patient outcomes. The clinical syndrome of HF is not a single disease, but represents the complex interplay between various cardiac and non-cardiac processes, each of which need ...
Shih Chia-Jen CJ School of Medicine, National Yang-Ming University, Taipei, Taiwan & Taipei Veterans General Hospital, Yuanshan Branch, Yilan, - - 2014
-Substantial infective endocarditis (IE)-related morbidity and mortality may occur even after successful treatment. However, no previous study has explored long-term hard endpoints (i.e., stroke, myocardial infarction, heart failure, cardiovascular death) in addition to all-cause mortality in IE survivors. -A nationwide population-based cohort study was conducted among IE survivors identified using ...
Monfredi Oliver O From the Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom (O.M., H.S., M.N., M.R.B.); Laboratory of Cardiovascular Science, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD (O.M., A.E.L., V.A.M., E.G.L.); K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway (A.-B.J., U.W.); Laboratory of Biomedical Sciences and Information Management, National Cerebral and Cardiovascular Center, Osaka, Japan (S.I.); and Biological Physics Group, University of Manchester, Manchester, United Kingdom (R.W., H.Z.). - - 2014
Heart rate (HR) variability (HRV; beat-to-beat changes in the R-wave to R-wave interval) has attracted considerable attention during the past 30+ years (PubMed currently lists >17 000 publications). Clinically, a decrease in HRV is correlated to higher morbidity and mortality in diverse conditions, from heart disease to fetal distress. It ...
Malfatto Gabriella G aDivisione di Cardiologia, Ospedale San Luca, Istituto Auxologico Italiano IRCCS bDipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università di Milano-Bicocca, Milan, - - 2014
In chronic heart failure, changes of intra-thoracic impedance (Z0IT) may suggest impending pulmonary congestion; a similar result has been found by measuring trans-thoracic conductance (TFCTT = 1/Z0 = 1/kΩ). We assumed that a relationship could exist between Z0IT and TFCTT. We collected 140 measurements from 70 patients carrying an implantable cardioverter-defibrillator/cardiac resynchronization device with ...
Chang Po-Cheng PC Division of Cardiology, Department of Internal Medicine, Linko, Chang Gung Memorial Hospital, Taipei, Taiwan; Chang Gung University College of Medicine, Taoyuan, - - 2014
Na(+)/Ca(2+) exchanger blockade has been reported to be anti-arrhythmic in different models. The effects of KB-R7943, a Na(+)/Ca(2+) exchanger blocker, on arrhythmogenesis in hearts with chronic myocardial infarction (MI) remain unclear. Dual voltage and intracellular Ca(2+) (Cai) optical mapping was performed in nine rabbit hearts with chronic MI and four ...
Schmidt Michael Rahbek MR Department of Cardiology, Aarhus University Hospital Skejby, DK-8200 Aarhus N, - - 2014
Conditioning the heart to resist predictable and unpredictable ischemia-reperfusion injury is one of the fastest growing areas of bench to bedside research within cardiology. Basic science has provided important insight into signaling pathways and protective mechanisms in the heart, and a growing number of clinical studies have, with important exceptions, ...
Sugaya Nagisa N Department of Epidemiology and Public Health, Graduate School of Medicine, Yokohama City University, Yokohama, - - 2014
Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) may reflect central noradrenergic activity. In this study, we investigated salivary MHPG changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30 min after awakening to determine MHPG and cortisol. ...
Mine Takanao - - 2014
It is not clear whether patients with sinus rhythm and reduced left ventricular function should be treated with anticoagulation therapy during or after treatment for heart failure. A 67-year-old Japanese man was hospitalized at our institution with heart failure due to dilated cardiomyopathy. On day after discharge, he developed cerebral ...
Li Shujuan S 1Department of Paediatric Cardiology,The First Affiliated Hospital of Sun Yat-Sen - - 2014
Objectives: This study sought to evaluate left ventricular, right ventricular, and left atrial mechanics and their interactions in patients with congenital scoliosis without clinical heart failure. Methods: A total of 23 patients with a median age of 14 years and a median Cobb's angle of 61° were studied. Ventricular and ...
Barold S Serge SS Florida Heart Rhythm Institute, Tampa, - - 2014
Some devices used for cardiac resynchronization therapy (CRT) can sense from the left ventricular (LV) lead as in Biotronik CRT devices (Biotronik GmbH, Berlin, Germany), whose special LV timing cycles form the basis of this report. LV sensing (LVs) was designed to prevent competitive pacing outside the LV myocardial absolute ...
Defauw Arne A Ghent - - 2014
Rotors occurring in the heart underlie the mechanisms of cardiac arrhythmias. Answering the question whether or not the location of rotors is related to local properties of cardiac tissue has important practical applications. This is because ablation of rotors has been shown to be an effective way to fight cardiac ...
Kilic Ana A University of Western - - 2014
Na+/H+ exchanger 1 (NHE-1) inhibition attenuates the hypertrophic response and heart failure in various experimental models. As the hypertrophic program is rapidly initiated following insult we investigated whether early and transient administration of an NHE-1 inhibitor will exert salutary effects on cardiomyocyte hypertrophy or heart failure using both in vitro ...
Yeboah Joseph J Departments of Internal Medicine, Winston - Salem MC; Cardiology, Wake Forest University School of Medicine, Winston - Salem MC; Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC. Electronic address: - - 2014
Limited data exist on the association between LV dilation/remodeling and incident heart failure (HF), especially in adults without prior myocardial infarction and valvular heart disease. We assessed the association between left ventricular (LV) dilation and remodeling, and incident heart failure in a multi ethnic cohort METHODS: 4974 of 6814 participants ...
van Buchem Mark A MA Department of Radiology, Leiden University Medical Center, Leiden, The - - 2014
While both cardiac dysfunction and progressive loss of cognitive functioning are prominent features of an aging population, surprisingly few studies have addressed the link between heart and brain function. This is probably due to the monodisciplinary approach to these problems by cardiologists, neurologists, and geriatricians. Recent data indicate that autoregulation ...
Verbeni Antonella - - 2014
Nowadays advanced heart failure is mainly treated through heart transplantation. However, the low availability of donors makes the research of alternative therapies urgent. Continuous-flow left ventricular assist devices (LVADs) are going to assume a more significant role in assisting the failing heart. A recent challenge in clinical practice is the ...
Chamberlain Alanna M AM Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55905, USA. Electronic address: - - 2014
Comorbidities are a major concern in heart failure, leading to adverse outcomes, increased healthcare utilization, and excess mortality. Nevertheless, the epidemiology of comorbid conditions and differences in their occurrence by type of heart failure and sex are not well documented. The prevalence of 16 chronic conditions defined by the US ...
Kleinbongard P P Institute for Pathophysiology, West German Heart and Vascular Center, University School of Medicine Essen, Essen, - - 2014
In patients with acute myocardial infarction, timely reperfusion is mandatory to limit infarct size. However, reperfusion also adds to myocardial injury. Brief episodes of ischaemia/reperfusion in the myocardium or on organ remote from the heart, prior to or shortly after sustained myocardial ischaemia effectively reduce infarct size, provided there is ...
Wang Lijuan L Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, - - 2014
Aldosterone synthase (CYP11B2) is one of the most studied candidate genes related to essential hypertension (EH) and left ventricular hypertrophy (LVH). Some studies have focused on the relationship between -344C/T polymorphism (rs1799998) in the CYP11B2 gene and LVH, but the results are controversial. This meta-analysis is purposed to reveal the ...
Passino Claudio C Division of Cardiology and Cardiovascular Medicine, Fondazione G. Monasterio CNR-Regione Toscana; Scuola Superiore Sant'Anna, Pisa, Italy. Electronic address: - - 2014
Ventricular remodeling occurs progressively in untreated patients after large myocardial infarction and in those with cardiomyopathy. The pathologic changes of increased left ventricular (LV) volume and perturbation in the LV chamber geometry involves not only the myocytes, but also non-myocyte cells and the extracellular matrix. Inflammation, fibrosis, neuro-hormonal activation, and ...
Buchhorn Reiner R Chefarzt der Klinik Kinder- und Jugendmedizin Caritas-Krankenhaus Uhlandstr. 7 97980 Bad Mergentheim Germany.. - - 2014
The prevalence of heart failure in patients with congenital heart disease, mainly due to large left to right shunts, is as high as 20%. Heart failure has a high impact on prognosis, growth and neurodevelopment. Prior to surgery or after palliative procedures children need a medical heart failure therapy. The ...
Ostman-Smith Ingegerd I Division of Paediatric Cardiology Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Sweden. - - 2014
Congestive cardiac failure accounts for 36% of childhood deaths in hypertrophic cardiomyopathy, and in infants with presentation with heart failure symptoms before two years of age, the mortality is extremely high unless treatment with beta-receptor antagonists is instituted. The mechanism of heart failure is not systolic dysfunction, but rather extreme ...
Prijic Sergej S Pediatric Cardiologist Assistant Professor of Pediatrics Mother and Child Health Institute of Serbia R. Dakica St. 6-8; 11070 Belgrade, Serbia School of Medicine - University of Belgrade Dr Subotica St. 8, 11000 Belgrade, Serbia. - - 2014
Patients with chronic heart failure have prolonged sympathetic stimulation and subsequent worsening of the failing heart function. Beta-blockers (non-selective, cardio-selective, and non-selective with ancillary properties) counteract the effects of prolonged sympathetic stimulation. Beta-blocker therapy results in the improvement of the left ventricular systolic and diastolic function, reversal remodeling, heart rate ...
Prijic Sergej - - 2014
Background.Numerous prospective randomized clinical trials demonstrated favorable effect of beta-blockers in adults with chronic heart failure. However, effectiveness of beta blockers in pediatric patients with systemic ventricle systolic dysfunction was not recognized sufficiently. Limited number of pediatric patients might be the course of unrecognized carvediolol treatment benefit. Currently, no meta-analysis ...
Dodd Michael S MS Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom - - 2014
-Myocardial infarction (MI) is one of the leading causes of heart failure. An increasing body of evidence links alterations in cardiac metabolism and mitochondrial function with the progression of heart disease. The aim of this work was to therefore follow the in vivo mitochondrial metabolic alterations caused by MI, thereby ...
Matsumura Tsuyoshi T Department of Neurology National Hospital Organization Toneyama National Hospital Toneyama 5-1-1 Toyonaka Osaka 550-8552 Japan. - - 2014
Respiratory failure and heart failure are inevitable complications in Duchenne muscular dystrophy (DMD). Respiratory failure and heart failure undergo simultaneously and affect each other. After dissemination of mechanical ventilation, heart failure is the main cause of death in DMD. Regular assessment of cardiopulmonary function, early introduction of cardioprotective therapy and ...
Akhmedov Alexander T AT The Molecular Cardiology and Neuromuscular Institute, 75 Raritan Avenue, Highland Park, NJ, 08904, - - 2014
Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction, progressing eventually to the final end point heart failure (HF), remain the leading cause of morbidity and mortality in the USA. HF is a complex syndrome that results from any structural or functional impairment in ventricular filling or blood ejection. ...
Myles Rachel C RC Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, - - 2014
Heart failure (HF) results in dramatic electrophysiological remodeling, including increased sensitivity of ryanodine receptors (RyR) and decreased inward rectifying K(+) current (IK1), which predisposes HF myocytes to delayed afterdepolarizations and triggered activity. Therefore, we sought to determine the role of increased RyR sensitivity and decreased IK1 in contributing to focal ...
Dawson Alan G AG Department of Cardiothoracic Surgery, Aberdeen Royal Infirmary, Aberdeen, UK - - 2014
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was 'Is the placement of an Amplatzer septal occluder device across a post-infarction ventricular septal defect a suitable alternative for patients not eligible for surgical repair?' Altogether, 31 papers were found using the ...
Swidan M M MM Labeled Compound Department, Hot Labs Center, Atomic Energy Authority, PO13759, Cairo, - - 2014
Acebutolol was successfully labeled with (125) I via direct electrophilic substitution reaction. Radioiodinated acebutolol was prepared with a maximum radiochemical yield of 96.5 ± 0.3% and in vitro stability up to 72 h. The in vivo biological distribution of radioiodinated acebutolol showed high heart uptake of 37.8 ± 0.14% injected activity/g organ with low lungs ...
Ali Abdellah Hamed Khalil AH Department of Respiratory Medicine, Faculty of Medicine, Sohag University, Egypt; Department of Oncological Medical Services, Institute of Health Biosciences, The University of Tokushima Graduate School, - - 2014
The changes of autonomic nervous activity during bronchoscopic procedures are closely related to the development of cardiovascular complications. We aimed to evaluate the changes of autonomic nervous activity during bronchoscopic procedures using R-R interval variability from electrocardiograms obtained during diagnostic bronchoscopy. Twenty-four patients who underwent bronchoscopy were included. Continuous electrocardiogram ...
Catena Cristiana C Hypertension Unit, Division of Internal Medicine, Department of Experimental and Clinical Sciences, University of Udine, 33100, Udine, - - 2014
Both hyperuricaemia and left ventricular (LV) hypertrophy are associated with the metabolic syndrome and increased cardiovascular risk. The relationship between uric acid levels and left ventricular mass in hypertension, however, is unclear. In this study, we have investigated this relationship in hypertensive patients without the metabolic syndrome. In a cross-sectional ...
Scirica Benjamin M BM Brigham and Women's Hospital and Harvard Medical School, Boston, MA - - 2014
-Diabetes and heart failure frequently coexist. However, few diabetes trials have prospectively evaluated and adjudicated heart failure as an endpoint. -16,492 patients with type 2 diabetes and a history of, or at risk for, cardiovascular events were randomized to saxagliptin or placebo (mean followup-2.1 years). The primary endpoint was the ...
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