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Vargas-Uricoechea Hernando H Division of Endocrinology and Metabolism, Internal Medicine Department, University of Cauca, Popayán-Cauca, Colombia. Electronic address: - - 2014
Thyroid hormones have a significant impact on heart function, mediated by genomic and non-genomic effects. Consequently, thyroid hormone deficiencies, as well as excesses, are expected to result in profound changes in cardiac function regulation and cardiovascular hemodynamics. Thyroid hormones upregulate the expression of the sarcoplasmic reticulum calcium-activated ATPase and downregulate ...
Søndergaard Eva Bjerre - - 2014
Abstract Objectives: The objective of the study was to analyse the outcome of patients with advanced heart failure due to abuse of anabolic-androgenic steroids. Design: A retrospective chart review of patients admitted or referred for advanced heart failure, due to anabolic androgenic steroid abuse, in the period 2009 to 2013 ...
Okin Peter M PM aGreenberg Division of Cardiology, Weill Cornell Medical College, New York, New York, USA bGlostrup University Hospital, Copenhagen, Denmark cUniversity of Bergen, Bergen, Norway dSahlgrenska University Hospital/Östra, Gothenburg, - - 2014
Persistence or development of ECG left ventricular hypertrophy (LVH) by Cornell product criteria is associated with an increased risk of developing heart failure compared with regression or continued absence of LVH. We postulated that this association might be in part mediated via worse left ventricular systolic function in patients with ...
Mahr Claudius C Division of Cardiology, University of Washington, Seattle, WA, 98195, - - 2014
Advanced heart failure describes the subset of heart failure patients refractory to conventional medical therapy. For some advanced heart failure patients, the use of mechanical circulatory support provides an intermediary "bridge" step for transplant eligible patients or an alternative therapy for transplant ineligible patients. Over the past 20 years, clinical ...
Osadchii Oleg E - - 2014
Abstract Objectives. In the clinical setting, patients with slower resting heart rate are less prone to cardiovascular death compared to those with elevated heart rate. However, electrophysiological adaptations associated with slowed cardiac rhythm have not been thoroughly explored. In this study, relationships between intrinsic heart rate and arrhythmic susceptibility were ...
Fouzas Sotirios S Neonatal Intensive Care Unit, University Hospital of Patras and University of Patras Medical School, Patras, Greece; Department of Pediatrics, University Hospital of Patras and University of Patras Medical School, Patras, Greece. Electronic address: - - 2014
Intrauterine growth restriction (IUGR) is associated with structural and functional cardiac alterations but the electrophysiological consequences of these disturbances remain unknown. To explore the distribution of ventricular repolarization and its relation to myocardial mechanics in newborns with IUGR. Conventional and tissue Doppler echocardiographic data, and electrocardiographic parameters used to describe ...
Hacking Douglas F DF Department of Paediatric Intensive Care, The Royal Children's Hospital, Melbourne, Victoria, Australia; Department of Anaesthetics, Saint Vincent's Hospital, Melbourne, Victoria, - - 2014
We aimed to determine the effect of elective left heart decompression at the time of initiation of central venoarterial extracorporeal membrane oxygenation (VA ECMO) on VA ECMO duration and clinical outcomes in children in a single tertiary ECMO referral center with a large pediatric population from a national referral center ...
Kikuchi C C Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Anesthesiology, Asahikawa Medical University, Asahikawa, - - 2014
The pharmacological conditioning of the heart with anaesthetics such as volatile anaesthetics or opioids is a phenomenon whereby a transient exposure to an anaesthetic agent protects the heart from the harmful consequences of myocardial ischemia and reperfusion injury. The cellular and molecular mechanisms of anaesthetic conditioning appear largely to mimic ...
Paglia Antonella A Department of Translational Medical Sciences- Section of Internal Medicine, University of Naples Federico - - 2014
Central aortic pressure waveform (AoPW) is the summation of a forward-traveling wave generated by the left ventricle and a backward-traveling wave caused by the reflection of the forward wave. The aim of this study was to evaluate the effect of ventricular-vascular coupling on the morphology of AoPW in chronic heart ...
Coffin Samuel T ST Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, - - 2014
: Eosinophilic myocarditis is a rare condition in which inflammation of the heart results in an infiltrative cardiomyopathy that is often difficult to diagnose in the acute setting. It sometimes presents as left ventricular hypertrophy. The authors present a case of a 79-year-old woman with a history of Non-Hodgkin's lymphoma ...
Camer Danielle D School of Medicine, and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, - - 2014
Bardoxolone methyl has been reported to cause detrimental cardiovascular events in the terminated BEACON Phase III human clinical trial via modulation of the renal endothelin pathway. However, the effects of bardoxolone methyl administration on the endothelin pathway in the heart are unknown. Our purpose in this perspective is to highlight ...
Amundson Beret E - - 2014
Abstract Cardiac troponin (cTn) I and T are released from myocardial cells following necrosis, i.e., cell death. An accurate measure of cTn concentrations in a patient's blood following ischemia/chest pain can enable providers to determine whether or not a myocardial infarction (MI) has occurred. Point-of-care (POC) devices that measure blood ...
Grodin Justin L JL Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH - - 2014
Cardiac troponin levels offer prognostic information for patients with heart failure. Highly sensitive assays detect levels of cTn much lower than the 99th percentile of standard cTn assays. We hypothesize that cardiac troponin (cTn) levels measured by a high sensitivity assay provide better prognostic value compared to cTn levels measured ...
Rickard John J Division of Electrophysiology, Department of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address: - - 2015
Patients with ambulatory New York Heart Association (NYHA) class IV heart failure were significantly underrepresented in clinical trials of cardiac resynchronization therapy (CRT). The natural long-term trajectory of survival free of left ventricular assist device (LVAD) or heart transplant in patients with ambulatory class IV symptoms who underwent CRT has ...
Diakos Nikolaos A NA Utah Transplantation Affiliated Hospitals (UTAH) Cardiac Transplant Program: Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health Sciences Center, Intermountain Medical Center, Veterans Administration Salt Lake City Health Care System, Salt Lake City, Utah; University of Utah Molecular Medicine Program, Salt Lake City, - - 2014
In animal models of heterotopic transplantation, mechanical unloading of the normal, nonhypertrophic heart results in atrophy. Primarily on the basis of these animal data, the notion that chronic left ventricular assist device (LVAD)-induced unloading will result in atrophy has dominated the clinical heart failure field, and anti-atrophic drugs have been used ...
Weinheimer Carla J CJ Center for Cardiovascular Research, Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri, United States of - - 2014
Mouse surgical models are important tools for evaluating mechanisms of human cardiac disease. The clinically relevant co-morbidities of hypertension and ischemia have not been explored in mice. We have developed a surgical approach that combines transverse aortic constriction (TAC) and distal left anterior coronary ligation (MI) to produce a gradual ...
Nagao Michinobu M Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu - - 2014
The aims of this study were to quantify the geometrical differences in left ventricular (LV) dyssynchrony in patients with heart failure (HF) using cine-tagged MRI, and to investigate the relationship between dyssynchrony and major adverse cardiac events (MACE) in HF.In 67 patients with HF [mean LV ejection fraction (LVEF), 34%], ...
Watanabe Atai A Institute of Medical Science, The University of - - 2014
Anticoagulants such as warfarin are recommended for patients with atrial fibrillation (AF) to decrease stroke risk associated with thrombus formation in the left atrium (LA). In a subgroup of patients, however, warfarin is unable to prevent LA thrombus formation at therapeutic doses. This study characterized the clinical and echocardiographic features ...
Sobanski Piotr P aHildegard Palliative Centre Basel bGynaecological Cancer Centre, University Hospital Basel, Basel, Switzerland cDepartment of Social and Welfare Studies, Linköping University, Linköping, Sweden dDepartment of Palliative Care, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, - - 2014
Until recently, concepts of care for people with heart failure had rarely included preparation for unavoidable imminent death or caring for the dying.The purpose of this review is to provide an update on current end-of-life issues specific to heart failure patients. Mortality in the heart failure population remains high, especially ...
Yu Jiangbo J Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. - - 2014
Matrine, an alkaloid isolated from the traditional Chinese medicine Sophora flavescens AIT has exhibited a number of therapeutic effects on cardiovascular and liver diseases. The purpose of the present study was to investigate whether matrine has a protective effect on heart failure in rats. Coronary artery ligation was used to ...
Roberts William C WC Baylor Heart and Vascular Institute, Baylor University Medical Center at Dallas, Texas; Department of Internal Medicine (Division of Cardiology), Baylor University Medical Center at Dallas, Texas; Department of Pathology, Baylor University Medical Center at Dallas, Texas. Electronic address: - - 2014
Although mortality rates during acute myocardial infarction (AMI) continue to drop, cardiac rupture (left ventricular free wall [LVFW] or ventricular septum [VS] or papillary muscle [PM] or combination) remains relatively common. The aim was to identify commonalities among patients with AMI complicated by cardiac rupture. During a 22-year period (1993-2014) ...
Armstrong Danielle D Department of Pathology, Baylor University Medical Center, Dallas, - - 2014
Described herein are clinical and morphologic findings in 2 patients who underwent heart transplantation because of severe heart failure resulting from cardiac sarcoidosis. Although the explanted hearts in each patient had characteristic gross changes of cardiac sarcoidosis, one patient who had been treated with prednisone, had no residual sarcoid granulomas ...
Hoyer Alexandro A Department of Cardiac Surgery, University of Leipzig, Heart Center Leipzig, Struempellstrasse 39, 04289, Leipzig, Germany, - - 2014
Evidence as to how ACE inhibitors attenuate ischemia-reperfusion injury (IR) after cardioplegic arrest remains scarce. Twenty-four rabbit hearts were perfused on a Langendorff apparatus. Control hearts (n = 6) were arrested with pure histidine-tryptophan-ketoglutarate (HTK)-Bretschneider. Treatment groups received added to the cardioplegic solution (n = 6) captopril (100 μmol/l) and losartan (100 μmol/l) for selective AT1-receptor ...
Harvey Richard P RP Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst 2010, New South Wales, Australia. Electronic address: - - 2014
Despite therapeutic advances that slow its progression, heart disease remains the world's leading cause of death. Until recently, the "Holy Grail" of cardiac biology, to regenerate the damaged heart, appeared to be a fantastical and quixotic quest. However, recent studies showing that the mammalian heart possesses an innate, albeit limited, ...
den Uil Corstiaan A CA Department of Cardiology, Erasmus Medical Center, Thoraxcenter, 's-Gravendijkwal 230, 3015, CE Rotterdam, The Netherlands, - - 2014
Intravenous nitroglycerin is a well-known, but underused, treatment for acute decompensated heart failure. Nitroglycerin has a rapid onset of action and short half-life and there is a clear dose-response curve on both global hemodynamics and peripheral circulation. IV nitroglycerin reduces LV and RV filling pressures and afterload. In the case ...
Hürlimann David D Department of Cardiology, Invasive Electrophysiology and Devices, University Heart Center Zurich, Zurich, - - 2014
Various studies have attempted to identify super-responders to cardiac resynchronization therapy (CRT) by echocardiographic parameters of reverse remodeling. However, scientific evidence regarding those parameters is scarce. This study aimed at validating the definition of super-response to CRT based on the following frequently employed echocardiographic parameters: left ventricular ejection fraction (LVEF), ...
Kydd Anna C AC Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, - - 2014
Optimal delivery of CRT requires appropriate patient selection and device implantation. Echocardiographic predictors of CRT response individually appear to enhance patient selection, but do not fully reflect the complex underlying myocardial dysfunction. We hypothesized that a multiparametric approach would offer greater predictive value and sought to derive a score incorporating ...
Li Jifen J Center for Translational Medicine, Thomas Jefferson - - 2014
Rationale: Shortly after birth, muscle cells of the mammalian heart lose their ability to divide. Thus, they are unable to effectively replace dying cells in the injured heart. The recent discovery that the transcriptional co-activator Yap is necessary and sufficient for cardiomyocyte proliferation has gained considerable attention. However, the upstream ...
Fox P R PR The Animal Medical Center, New York, - - 2014
Cardiac biomarkers provide objective data that augments clinical assessment of heart disease (HD). Determine the utility of plasma N-terminal pro-brain natriuretic peptide concentration [NT-proBNP] measured by a 2nd generation canine ELISA assay to discriminate cardiac from noncardiac respiratory distress and evaluate HD severity. Client-owned dogs (n = 291). Multicenter, cross-sectional, prospective investigation. ...
Zhang Wei W Pharmacy Department of Yulin First Hospital, Second Affiliated Hospital of Yanan University, Yulin Shaanxi, 719000, PR - - 2014
The present study was designed to investigate whether oxymatrine could attenuate isoproterenol-induced heart failure via regulation of asymmetric dimethylarginine (ADMA) metabolism in rats. Heart failure model was established by once daily subcutaneous injection of isoproterenol (5mg/kg/d) to rats for 7 days. Simultaneously, oral administration of oxymatrine (25, 50 and 100mg/kg/d, ...
Smith Daryl I DI 1 Department of Anesthesiology, 2Division of Cardiac Surgery, 3Division of Thoracic and Foregut Surgery, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 604, Rochester, NY - - 2014
Stellate ganglion blockade for cardiac dysrhythmia is a well described but infrequently used technique to manage ventricular tachycardia (VT). In patients with left ventricular assist devices (LVAD), these dysrhythmias cause increased morbidity because of right ventricular dysfunction, and often severe discomfort. Continuous stellate ganglion blockade may yield valuable information on ...
Chin Melanie P MP Reata Pharmaceuticals, Irving, TX, - - 2014
A phase 3 randomized clinical trial was designed to test whether bardoxolone methyl, a nuclear factor-erythroid-2-related factor-2 (Nrf2) activator, slows progression to end-stage renal disease in patients with stage 4 chronic kidney disease and type 2 diabetes mellitus. The trial was terminated because of an increase in heart failure in ...
Toldo Stefano S VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA; Victoria Johnson Research Laboratory, Virginia Commonwealth University, Richmond, VA, - - 2014
Impairment in the myocardial relaxation and/or of the ventricular compliance determines the presence of diastolic dysfunction. Diastolic dysfunction in the heart may occur as a result of normal aging, but it more often is caused by metabolic or structural abnormalities in the myocardium, which are the substrate for diastolic heart ...
Woo Anthony Yiu-Ho AY Institute of Molecular Medicine, Centre for Life Sciences, Peking University, Beijing 100871, China; Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, - - 2014
The body is constantly faced with a dynamic demand of blood flow. The heart is able to respond to these changing needs by adjusting cardiac output based on the cues of the circulating catechnolamine levels. Cardiac β-adrenoceptors transduce the signal of catecholamine stimulation via Gs proteins to their downstream effectors ...
Saito Tomohiro T Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Osaka, - - 2014
Right ventricular failure after left ventricular assist device (LVAD) implantation is associated with high mortality. This study was designed to evaluate the effectiveness of an atrial septostomy with a membrane oxygenator incorporated in an LVAD as a novel approach for right ventricular failure after LVAD implantation. The outflow and inflow ...
Hayashi Ichiro I Department of Cardiovascular Surgery, National Hospital Organization Saitama National Hospital, Wako City, Saitama, Japan - - 2014
Because of the difficulty in placing a suture-supporting extension to a non-infarcted area, ventricular septal perforation repair in the presence of large myocardial infarctions can give rise to life-threatening tears or ruptures of the left ventricular free wall. We report a case of successful reinforcement of an infarction area from ...
Cho M J MJ Pediatrics, Medical Research Institute of Pusan National University Hospital, Pusan NationalUniversity School of Medicine, South Korea - - - 2014
The effects of beta--blockers in pediatric and congenital heart disease (CHD) patients suffering from heart failure are controversial. We performed a meta--analysis to determine whether beta--blockers are effective for heart failure in pediatric and CHD patients. We searched for clinical trials focusing on clinical on clinical and ventricular functional / ...
Neragi-Miandoab S S Department of Cardiothoracic Surgery, Montefiore Medical Center, Albert Einstein College ofMedicine, Bronx, NY, USA - - - 2014
Congestive heart failure (CHF) results from damage to the myocardium and has a broad etiology ranging from ischemic to non--ischemic etiology. It is one of the leading causes of cardiovascular morbidity and mortality and carries a 5--year mortality of 50%, estimated by WHO to represent 30% of deaths in the ...
Forti Alessandro A Anesthesia Department, Regional Hospital Treviso, Treviso, Italy; Intensive Care Department, Regional Hospital Treviso, Treviso, Italy; Emergency Department, Regional Hospital Treviso, Treviso, - - 2014
Despite early cardiopulmonary resuscitation (CPR) by bystanders and early advanced cardiac life support (ACLS) maneuvers, some patients present to the emergency department with persistent cardiac arrest caused by a coronary artery occlusion. Although emergency percutaneous intervention (PCI) has been shown to be effective in improving survival, transporting patients in cardiac ...
Dedkov Eduard I EI Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA - - 2014
A large myocardial infarction (MI) initiates progressive cardiac remodeling that leads to systolic heart failure (HF). Long-term heart rate reduction (HRR) induced by the I f current inhibitor ivabradine (IVA) ameliorates left ventricular (LV) remodeling and improves systolic performance in young post-MI rats. However, the beneficial effects of chronic IVA ...
Lavie Carl J CJ Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA; Cardiac Rehabilitation, Exercise Laboratories, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA; Department of Preventive Medicine, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Electronic address: - - 2015
Obesity adversely affects many cardiovascular disease (CVD) risk factors and increases the risk of most CVD, including heart failure (HF). HF is markedly increased in the setting of obesity. However, obese patients with HF have a better prognosis than lean patients with HF, which has been termed the obesity paradox. ...
Meloni Antonella A CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, - - 2014
The multislice multiecho T2* cardiovascular magnetic resonance (CMR) technique allows to detect different patterns of myocardial iron overload (MIO). The aim of this cross-sectional study was to verify the association between cardiac complications (heart failure and arrhythmias), biventricular dysfunction and myocardial fibrosis with different patterns of MIO in thalassemia major ...
Teo Koon K KK Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada. Electronic address: - - 2014
This position statement addresses issues in revascularization for multivessel coronary artery disease (CAD) from the perspective of both cardiologists and cardiac surgeons. Recommendations are made based on evidence from clinical trials and observational studies, with an emphasis on the increasing number of individuals with significant comorbid disease burden and functional ...
Ciszewski Jan - - 2014
The only subgroups of patients with heart failure and atrial fibrillation in which the efficacy of cardiac resynchronization therapy has been scientifically proven are patients with indications for right ventricular pacing and patients after atrioventricular junction ablation. However it is unlikely that atrioventricular junction ablation would be a standard procedure ...
Habek Jasna Cerkez JC Department of Cardiology, Croatian Catholic University, University Hospital Sveti Duh, Zagreb, - - 2014
To assess the prevalence of left ventricular diastolic dysfunction in a population of patients with type 2 diabetes mellitus; to determine correlation of diastolic dysfunction with heart rate and its variability. The study included 202 patients with type 2 diabetes mellitus. Echocardiography was performed with special reference to diastolic function, ...
Al-Biltagi Mohammed A MA Pediatric Department, Faculty of Medicine,Tanta - - 2014
Objective: To evaluate the presence of cardiac dyssynchrony in Egyptian children with congestive heart failure due to dilated cardiomyopathy. Materials and methods: A total of 30 children with congestive cardiac failure due to dilated cardiomyopathy and 30 healthy age-matched controls were examined with conventional echocardiography, tissue Doppler, and speckle tracking ...
Haeck M L A ML Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the - - 2014
Mechanical circulatory support with a continuous-flow left ventricular assist device (LVAD) may be a valuable treatment in end-stage heart failure patients for an extended period of time. The purpose of this study was to evaluate the safety and efficacy of implantation of a continuous-flow LVAD in end-stage heart failure patients ...
Borik Sharon S 1Department of Pediatrics,Labatt Family Heart Center,Division of Cardiology,University of Toronto School of - - 2014
Using phase-contrast MRI in a foetus with borderline left ventricular hypoplasia at 37 weeks' gestation we showed an increase in pulmonary blood flow during maternal hyperoxygenation. The associated increase in venous return to the left atrium, however, resulted in reversal of the atrial shunt, with no improvement in left ventricular ...
Jhund Pardeep S PS Cardiovascular Division, Brigham and Women's Hospital, Boston, MA; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United - - 2014
-Elevated high sensitivity troponin is associated with increasing disease severity in patients with stable heart failure with reduced ejection fraction, but less is known about the association in heart failure with preserved ejection fraction (HFpEF). -We examined the prevalence of elevated high sensitivity troponin T (hs-TnT) in 298 patients with ...
Li Lei L University of Washington, Seattle, - - 2014
-Programmed necrosis (necroptosis) plays an important role in development, tissue homeostasis, and disease pathogenesis. The molecular mechanisms that regulate necroptosis in the heart and its physiological relevance in myocardial remodeling and heart failure remain largely unknown. -Here we identified an obligate function for TAK1 (TGFβ-activated kinase 1, gene name Map3k7) ...
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