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Bro-Jeppesen John J From the Departments of Cardiology (J.B.-J., C.H., L.K., J.K.) and Cardiothoracic Anesthesia (M.W., M.O.), The Heart Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Anesthesia and Intensive Care, Lund University, Helsingborg Hospital, Helsingborg, Sweden (N.N.); and Departments of Cardiology (D.E.) and Anesthesia and Intensive Care (H.F.), Lund University, Skåne University Hospital, Lund, Sweden. - - 2014
Cardiovascular dysfunction is common after out-of-hospital cardiac arrest as part of the postcardiac arrest syndrome, and hypothermia may pose additional impact on hemodynamics. The aim was to investigate systemic vascular resistance index (SVRI), cardiac index, and myocardial performance at a targeted temperature management of 33°C (TTM33) versus 36°C (TTM36). Single-center ...
Srivatsan Varsha V Department of Cardiology, SRM Medical College Hospital and Research Centre, - - 2014
Heart failure (HF) continues to be an illness of daunting proportions with a four- year mortality touching 50%. Biomarkers for prognosticating patients with heart failure have generated immense interest. Several studies have been conducted on a novel biomarker, galectin-3 to assess its prognostic effect in heart failure populations. However, the ...
Rawat Dhawjbahadur K DK From the Departments of Biochemistry and Molecular Biology (D.K.R., R.G., S.C., S.A.G.), Pharmacology (A.A., I.F.M.), Lung Biology (A.A., I.F.M., S.A.G.), Internal Medicine (I.F.M.), and Pathology (A.G.K.), University of South Alabama, College of Medicine, Mobile; and Department of Physiology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan (M.W., - - 2014
Pulmonary arterial hypertension (PAH) is a debilitating and deadly disease with no known cure. Heart failure is a major comorbidity and a common cause of the premature death of patients with PAH. Increased asymmetrical right ventricular hypertrophy and septal wall thickening compress the left ventricular cavity and elicit diastolic heart ...
Bates Angelina A Olathe Cardiology Services, Olathe Medical Center, Olathe, Kansas, - - 2014
Diastolic heart failure, or heart failure with preserved ejection fraction, is a leading cause of morbidity and mortality. There are no current therapies effective in improving outcomes for these patients. The aim of this article is to review the literature and examine the role of coenzyme Q10 in heart failure ...
Anselmino Matteo M Cardiology Division, Department of Medical Sciences, University of Turin, Turin, - - 2014
-Catheter ablation of atrial fibrillation (AFCA) is an established therapeutic option for rhythm control in symptomatic patients. Its efficacy and safety among patients with left ventricular systolic dysfunction is based on small populations, and data concerning long-term outcome are limited. We performed this meta-analysis to assess safety and long-term outcome ...
Singh Robin Man RM Robin Man Singh, Department of Medicine, University of Louisville, Louisville, KY 40202, United - - 2014
Left ventricular ejection fraction (LVEF) is an important predictor of cardiac outcome and helps in making important diagnostic and therapeutic decisions such as the treatment of different types of congestive heart failure or implantation of devices like cardiac resynchronization therapy-defibrillator. LVEF can be measured by various techniques such as transthoracic ...
Pinchuk T V TV N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia, - - 2014
Proinflammatory markers were evaluated in patients with chronic heart failure of ischemic origin and essential hypertension with preserved left-ventricular ejection fraction before and after a 6-month course of simvastatin therapy (20 mg/day). The study was carried out in 125 patients with diastolic dysfunction manifested as impaired relaxation and pseudonormalization. The ...
Mamalyga M L ML Department of Anatomy and Physiology of Humans and Animals, Moscow State Pedagogical University, Moscow, Russia, - - 2014
Monitoring of the heart status during increasing stress-induced load allowed us to evaluate heart function after treatment of absence epilepsy with anticonvulsants of various types of action. Functional load against the background of treatment with lamotrigine or convulex had different effects on the dynamics of heart rate variability, hemodynamic parameters ...
Vardeny Orly O Department of Pharmacy, University of Wisconsin School of Pharmacy, Madison, Wisconsin. Electronic address: - - 2014
Neprilysin is an enzyme that contributes to the breakdown of the biologically active natriuretic peptides and several other vasoactive compounds. Inhibiting neprilysin has been a therapeutic target for several compounds that have been tested in cardiovascular disease, including ecadotril, candoxatril, omapatrilat, and LCZ696. Although ecadotril, candoxatril, and omapatrilat were initially ...
Shah Syed Raza SR Dow University of Health Sciences (DUHS), Karachi, Pakistan, - - 2014
The burden of noncommunicable diseases (NCDs) is emerging as a major public health challenge for the world. NCDs are projected to account for around 75 % of global mortality by the year 2020. The most common and problematic of all noncommunicable conditions is heart disease. As such, the weight of ...
Singh Mahipal M Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN - - 2014
Heart failure represents a major cause of morbidity and mortality in the western society. Cardiac myocyte loss due to apoptosis plays a significant role in the progression of heart failure. The extracellular matrix (ECM) maintains the structural integrity of the heart and allows the transmission of electrical and mechanical signals ...
Soeki Takeshi T Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. Electronic address: - - 2014
Ghrelin is a novel growth hormone (GH)-releasing peptide originally isolated from the stomach. Recently, we have shown that ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction. In the present study, we evaluated the effect of ghrelin on autonomic nerve activity in healthy ...
Morisawa Daisuke D *Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine †Division of Coronary Heart Disease, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, - - 2014
It remains unknown how sildenafil acutely provides hemodynamic alterations in patients with decompensated congestive heart failure. The aim of this study was to investigate whether myocardial and/or hemodynamic conditions affect hemodynamic response to sildenafil in patients with decompensated heart failure. Twenty five consecutive patients with decompensated congestive heart failure were ...
Abnousi Freddy F Stanford University, Stanford, CA. Electronic address: - - 2014
Heart failure with preserved ejection fraction is often thought of as "the other half" of all heart failure. It is similar to heart failure with reduced ejection fraction in incidence, prevalence, morbidity, mortality, and cost, yet there is still not a single therapy - device, pharmaceutical, or otherwise - that ...
Katz Daniel H DH Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, - - 2014
The purpose of this study was to determine the relationship between albuminuria and cardiac structure/function in heart failure with preserved ejection fraction (HFpEF). Albuminuria, a marker of endothelial dysfunction, has been associated with adverse cardiovascular outcomes in HFpEF. However, the relationship between albuminuria and cardiac structure/function in HFpEF has not ...
Gerede Demet Menekse DM Department of Cardiology, Ankara University School of Medicine, Ankara, - - 2014
Scleroderma is a connective tissue disease characterized by diffuse vascular lesions and fibrosis of the skin and major organs including lungs, kidneys, and heart. When cardiac involvement is clinically evident, it is recognized as a poor prognostic factor. The early detection of cardiac involvement in scleroderma would be desirable both ...
Garza Jennifer L JL Division of Occupational and Environmental Medicine, UConn Health, Farmington, CT, USA, - - 2014
High levels of workplace psychosocial factors have been associated with adverse cardiovascular outcomes, possibly through the pathway of increasing autonomic arousal. The purpose of this study was to investigate whether the workplace psychosocial factors of effort-reward imbalance (ERI) and overcommitment were associated with greater decreases in heart rate variability (HRV) ...
Crucean Adrian A 1Department of Paediatric Cardiac Surgery,Birmingham Children's Hospital,Birmingham,United - - 2014
Although holes, or channels, between the ventricles are the commonest congenital cardiac malformations, there is still no consensus as to how they can best be described and categorised. So as to assess whether it is possible to produce a potentially universally acceptable system, we have analysed the hearts categorised as ...
Moore J P JP Department of Pediatrics, Division of Pediatric Cardiology and the Ahmanson/UCLA Adult Congenital Heart Disease Center - - - 2014
Arrhythmia in the adult congenital heart disease (ACHD) population is recognized as a major source of morbidity and mortality and has contributed to an increasing burden on the health care system over the past several decades. Abnormalities of impulse formation and propagation encountered in this population are distinct from those ...
Agarwal Richa R Division of Cardiology, Department of Medicinea, Department of Cardiothoracic Surgeryb, Cardiovascular Institute, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, - - 2014
Management for continuous flow left ventricular assist device thrombosis often relies on speculation of individual clinical risk factors and integration of indirect evidence for device dysfunction. There are no comprehensive guidelines for treatment of this serious complication, and most of our current knowledge comes from anecdotal experience or observational study. ...
Patel Nikita M NM Department of Biomedical Engineering, Cullen College of Engineering, University of Houston, Houston, TX, - - 2014
Current therapies in left ventricular systolic dysfunction and end stage heart failure include mechanical assist devices and/or transplant. The development of a tissue-engineered integrative platform would present a therapeutic option which overcomes the limitations associated with current treatment modalities. This study provides a foundation for the fabrication and preliminary viability ...
Carrilho-Ferreira Pedro P Lisbon School of Medicine, Lisbon Academic Medical Center, CCUL, Lisbon University, Lisbon, - - 2014
Left ventricular non-compaction (LVNC) is thought to arise from arrest of the normal process of trabecular remodeling or "compaction" that takes place during embryonic life and is characterized by the presence of a two-layered ventricular wall, with a compact epicardial layer and a non-compacted endocardial layer. It is an uncommon ...
Lowalekar Samar K - - 2014
ObjectivesHearts preserved ex vivo at 4°C undergo time-dependent irreversible injury due to extreme hypothermia. Studies using novel organ preservative solution SOMAH, suggest that hearts are optimally `preserved¿ at subnormothermic temperature of 21°C. Present study evaluates relative efficacy of SOMAH `cardioplegia¿ at 4 and 21°C in preservation of optimum heart function ...
Attin Mina M School of Nursing, San Diego State University, 5500 Campanile Drive, San Diego, CA, 92182, USA, - - 2014
Survival after in-hospital cardiac arrest (I-HCA) remains < 30 %. There is very limited literature exploring the electrocardiogram changes prior to I-HCA. The purpose of the study was to determine demographics and electrocardiographic predictors prior to I-HCA. A retrospective study was conducted among 39 cardiovascular subjects who had cardiopulmonary resuscitation from ...
Pleister Adam A Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, - - 2014
The catastrophic consequences for patients in the settings of certain clinical conditions such as acute right ventricular infarction or massive pulmonary embolism with right heart failure illustrate the essential role that the right ventricle plays in sustaining life. With the development of more sophisticated diagnostic imaging technologies at the end ...
Limongelli Giuseppe G Division of Cardiology, Monaldi Hospital, Second University of Naples, Naples, - - 2014
The physiological importance of the right ventricle (RV) has been underestimated over the past years. Finally in the early 1950s through the 1970s, cardiac surgeons recognized the importance of RV function. Since then, the importance of RV function has been recognized in many acquired cardiac heart disease. RV can be ...
Gargiulo Paola P Department of Advanced Biomedical Sciences, Federico II University, Naples, - - 2014
For many years, the right ventricle (RV) has been considered a passive chamber with a relatively insignificant role in the overall functionality of the heart. More recently, the role of performance of RV in the clinical presentation and long-term prognosis of multiple pathological states, such as congenital heart diseases, chronic ...
Fernández-Jiménez Rodrigo R Department of "Atherothrombosis, Imaging and Epidemiology", Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro, 3. 28029, Madrid, - - 2014
Heart attack (myocardial infarction) is a highly prevalent entity worldwide. Widespread implementation of reperfusion strategies has dramatically reduced the mortality associated with infarction. Paradoxically, the mortality reduction has significantly increased the incidence of chronic heart failure (HF). Treatment of HF, once present, represents a huge socioeconomic burden on individuals and ...
Lai Ling L Diabetes and Obesity Research Center, Cardiovascular Pathobiology Program, Sanford-Burnham Medical Research Institute, Orlando, - - 2014
-An unbiased systems approach was utilized to define energy metabolic events that occur during the pathologic cardiac remodeling en route to heart failure. -Combined myocardial transcriptomic and metabolomic profiling were conducted in a well-defined mouse model of heart failure that allows comparative assessment of compensated and decompensated (heart failure) forms ...
Freites Alfonso A Department of Cardiology, University Hospital Fundacion Alcorcon, Madrid, - - 2014
We presented the case of an adult male without structural heart disease, who in the period of 3 years developed apical hypertrophic cardiomyopathy. ECG changes preceded the development of ventricular hypertrophy. We discussed the appearance of ventricular enlargement during adulthood, in some cases of hypertrophic cardiomyopathy (HC), and how the ...
Blechman Ido I Heart Failure Institute and Leviev Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, - - 2014
Improvement in the left ventricular ejection fraction (LVEF) may occur in patients with dilated cardiomyopathy (DCM). There are different implications of persistent versus transient improvement in LVEF among DCM patients receiving contemporary therapy. We studied 188 patients with nonischemic DCM. Persistent improvement in LVEF (PIEF) was defined as LVEF increase ...
Nearing Bruce D BD Division of Cardiovascular Medicine,  Department of Medicine,  Beth Israel Deaconess Medical Center,  Harvard-Thorndike Electrophysiology Institute, Harvard Medical School, Boston, - - 2014
Contemporary electrocardiographic (ECG) markers including ventricular ectopy and arrhythmias have not proved reliable in risk assessment for life-threatening arrhythmias. We developed the "Multilead ECG Template-Derived Residua" approach to remove intrinsic morphologic differences and allow calculation of pathologic ECG heterogeneities among spatially separated leads. Prediction by R-wave and T-wave heterogeneity (RWH, ...
McConnell Patrick I PI The Department of Cardiothoracic Surgery and Research Institute, Nationwide Children's Hospital1; Department of Surgery, The Ohio State University Wexner Medical Center2; Qtest Laboratories 3, Columbus, Ohio and the Department of Surgery and Wright State University, Dayton Ohio - - 2014
Direct mechanical ventricular actuation (DMVA) exerts direct cardiac compression/decompression and does not require blood contact. The safety and effects of DMVA support in chronically dysfunctional beating hearts in vivo have not been established. This study evaluated hemodynamics and load-independent systolic/diastolic cardiac function before/after acute support (2 hours) using DMVA in ...
Mada Razvan O - - 2014
Echocardiography is the standard method for assessing myocardial function in patients with ischemic heart disease. The acquisition and interpretation of echocardiographic images, however, remains a highly specialized task which often relies entirely on the subjective visual assessment of the reader and requires therefore, particular training and expertise. Myocardial deformation imaging ...
Moss Travis J TJ Cardiovascular Division, Department of Internal Medicine, and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA 22908, USA. Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, - - 2014
The original observation that reduced heart rate variability (HRV) confers poor prognosis after myocardial infarction has been followed by many studies of heart rate dynamics. We tested the hypothesis that an entropy-based local dynamics measure gave prognostic information in ambulatory patients undergoing 24-h electrocardiography. In this context, entropy is the ...
Slaughter Mark S MS 1Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY 40202 2Department of Bioengineering, University of Louisville, Louisville, KY 40202 3CorMatrix, Roswell - - 2014
Biomaterials with direct intramyocardial injection devices have been developed and are being investigated as a potential cardiac regenerative therapy for end-stage ischemic heart failure (IHF). Decellularized extracellular matrix (ECM) has been shown to improve cardiac function and attenuate or reverse pathologic remodeling cascades. CorMatrix Cardiovascular, Inc. has developed a porcine ...
Grosman-Rimon Liza L * Faculty of Kinesiology and Physical Education, University of Toronto † Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network ‡ Division of Nephrology, University Health Network, University of - - 2014
Although the newer continuous flow left ventricular assist devices (CF-LVADs) provide clinical advantages over the pulsatile pumps, the effects of low pulsatility on inflammation are incompletely understood. The objective of our study was to examine the levels of inflammatory mediators in CF-LVAD recipients compared to both healthy controls and to ...
Gregori Mario M aCardiology, Department of Clinical and Molecular Medicine, University of Rome 'Sapienza' bIRCCS Neuromed, Pozzilli, Italy cCardiology Unit, Department of Medicine, Karolinska Institute, Stockholm, - - 2014
Right ventricular dysfunction (RVD) is associated with poor cardiovascular outcome. The renin-angiotensin-aldosterone system is involved in alterations of the left ventricular geometry and function. Detrimental effects of the renin-angiotensin-aldosterone system on the right ventricular function are being postulated, but data supporting this assumption are still lacking. The aim of the ...
Bonadei Ivano I Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Study of Brescia, - - 2014
Although the introduction of novel medical and invasive therapies in recent years has led to a significant reduction in mortality from heart failure, the same cannot be said for mortality due to cardiogenic shock. Drug therapy with inotropic agents and catecholamines has the disadvantage of causing increased myocardial oxygen consumption ...
Yoshioka Daisuke D Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan - - 2014
We report the successful longest biventricular support using dual Jarvik 2000 biventricular assist device (BVAD; Jarvik Heart, Inc., New York, NY, USA) as a bridge to transplant. A 27-year old woman with arrhythmogenic right ventricular cardiomyopathy underwent implantation of two Jarvik 2000s as a left ventricular assist device and right ...
Vaduganathan Muthiah M Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, - - 2014
Heart failure (HF) accounts for over 1 million primary hospitalizations in the USA each year and carries a tremendous burden on costs and patient outcomes. The clinical syndrome of HF is not a single disease, but represents the complex interplay between various cardiac and non-cardiac processes, each of which need ...
Shih Chia-Jen CJ School of Medicine, National Yang-Ming University, Taipei, Taiwan & Taipei Veterans General Hospital, Yuanshan Branch, Yilan, - - 2014
-Substantial infective endocarditis (IE)-related morbidity and mortality may occur even after successful treatment. However, no previous study has explored long-term hard endpoints (i.e., stroke, myocardial infarction, heart failure, cardiovascular death) in addition to all-cause mortality in IE survivors. -A nationwide population-based cohort study was conducted among IE survivors identified using ...
Monfredi Oliver O From the Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom (O.M., H.S., M.N., M.R.B.); Laboratory of Cardiovascular Science, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD (O.M., A.E.L., V.A.M., E.G.L.); K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway (A.-B.J., U.W.); Laboratory of Biomedical Sciences and Information Management, National Cerebral and Cardiovascular Center, Osaka, Japan (S.I.); and Biological Physics Group, University of Manchester, Manchester, United Kingdom (R.W., H.Z.). - - 2014
Heart rate (HR) variability (HRV; beat-to-beat changes in the R-wave to R-wave interval) has attracted considerable attention during the past 30+ years (PubMed currently lists >17 000 publications). Clinically, a decrease in HRV is correlated to higher morbidity and mortality in diverse conditions, from heart disease to fetal distress. It ...
Malfatto Gabriella G aDivisione di Cardiologia, Ospedale San Luca, Istituto Auxologico Italiano IRCCS bDipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università di Milano-Bicocca, Milan, - - 2014
In chronic heart failure, changes of intra-thoracic impedance (Z0IT) may suggest impending pulmonary congestion; a similar result has been found by measuring trans-thoracic conductance (TFCTT = 1/Z0 = 1/kΩ). We assumed that a relationship could exist between Z0IT and TFCTT. We collected 140 measurements from 70 patients carrying an implantable cardioverter-defibrillator/cardiac resynchronization device with ...
Chang Po-Cheng PC Division of Cardiology, Department of Internal Medicine, Linko, Chang Gung Memorial Hospital, Taipei, Taiwan; Chang Gung University College of Medicine, Taoyuan, - - 2014
Na(+)/Ca(2+) exchanger blockade has been reported to be anti-arrhythmic in different models. The effects of KB-R7943, a Na(+)/Ca(2+) exchanger blocker, on arrhythmogenesis in hearts with chronic myocardial infarction (MI) remain unclear. Dual voltage and intracellular Ca(2+) (Cai) optical mapping was performed in nine rabbit hearts with chronic MI and four ...
Schmidt Michael Rahbek MR Department of Cardiology, Aarhus University Hospital Skejby, DK-8200 Aarhus N, - - 2014
Conditioning the heart to resist predictable and unpredictable ischemia-reperfusion injury is one of the fastest growing areas of bench to bedside research within cardiology. Basic science has provided important insight into signaling pathways and protective mechanisms in the heart, and a growing number of clinical studies have, with important exceptions, ...
Sugaya Nagisa N Department of Epidemiology and Public Health, Graduate School of Medicine, Yokohama City University, Yokohama, - - 2014
Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) may reflect central noradrenergic activity. In this study, we investigated salivary MHPG changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30 min after awakening to determine MHPG and cortisol. ...
Mine Takanao - - 2014
It is not clear whether patients with sinus rhythm and reduced left ventricular function should be treated with anticoagulation therapy during or after treatment for heart failure. A 67-year-old Japanese man was hospitalized at our institution with heart failure due to dilated cardiomyopathy. On day after discharge, he developed cerebral ...
Li Shujuan S 1Department of Paediatric Cardiology,The First Affiliated Hospital of Sun Yat-Sen - - 2014
Objectives: This study sought to evaluate left ventricular, right ventricular, and left atrial mechanics and their interactions in patients with congenital scoliosis without clinical heart failure. Methods: A total of 23 patients with a median age of 14 years and a median Cobb's angle of 61° were studied. Ventricular and ...
Barold S Serge SS Florida Heart Rhythm Institute, Tampa, - - 2014
Some devices used for cardiac resynchronization therapy (CRT) can sense from the left ventricular (LV) lead as in Biotronik CRT devices (Biotronik GmbH, Berlin, Germany), whose special LV timing cycles form the basis of this report. LV sensing (LVs) was designed to prevent competitive pacing outside the LV myocardial absolute ...
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