Search Results
Results 51 - 100 of 856
1 2 3 4 5 6 7 8 9 10 >
Dipoce Jason J Staff Radiologist Hadassah Medical Center Jerusalem, - - 2014
This article will familiarize the reader with several different cardiac devices including pacemakers and implantable cardioverter-defibrillators (ICDs), intra-aortic balloon pump, ventricular assist devices, valve replacements and repairs, shunt occluding devices and passive constraint devices. Many cardiac devices are routinely encountered in clinical practice. Other devices are in the early stages ...
Castaño Adam A Center for Advanced Cardiac Care, Columbia College of Physicians and Surgeons, New York City, NY, USA, - - 2014
Transthyretin-cardiac amyloidoses (ATTR-CA) are an underdiagnosed but increasingly recognized cause of heart failure. Extracellular deposition of fibrillary proteins into tissues due to a variety of inherited transthyretin mutations in ATTRm or due to advanced age in ATTRwt eventually leads to organ failure. In the heart, amyloid deposition causes diastolic dysfunction, ...
Moses-Arms Ashley A Department of Biological and Environmental Sciences, Texas A&M University-Commerce, Commerce, TX, 75429-3011, - - 2014
Heart disease is the number one killer in the USA, making cardiogenesis and its related pathways a relevant area of study for improving health and life expectancy. The Mexican salamander (axolotl), Ambystoma mexicanum, provides an excellent vertebrate animal model for studying myofibrillogenesis due to its naturally occurring cardiac nonfunction mutation. ...
Reddy Sushma S Department of Pediatrics, Stanford University, Stanford, CA, - - 2014
BackgroundAdrenergic receptor (ADR) genotypes are associated with heart failure (HF) and β-blocker response in adults. We assessed the influence of ADR genotypes in children with dilated cardiomyopathy (DCM).Methods91 children with advanced DCM and 44 with stable DCM were genotyped for 3 ADR genotypes associated with HF risk in adults: α2cdel322-325, ...
Stacey R Brandon RB Department of Internal Medicine Section on Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA, - - 2014
Left ventricular (LV) noncompaction cardiomyopathy (LVNC) is a form of cardiomyopathy in which trabeculations fail to "compact" with the left ventricular endocardium during fetal cardiac development and is classically associated with subsequent impairment of LV function, significant mortality, ventricular dysrhythmias, and embolic phenomena. As awareness and medical imaging quality have ...
Pfeffer Marc A MA Cardiovascular Division, Brigham and Women 's Hospital, 75 Francis Street, Boston, Massachusetts 02115 - - 2014
-Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) patients with heart failure and preserved left ventricular ejection fraction assigned to spironolactone did not achieve a significant reduction in the primary composite outcome (time to cardiovascular death, aborted cardiac arrest, or hospitalization for management of heart failure) ...
Champion Sébastien S Intensive Care Unit, University Hospital de la Réunion, Saint Denis - - - 2014
We report the case of a 49-year-old woman who experienced an inferior myocardial infarction with right ventricular extension, poorly tolerated, partly due to a severe rheumatic mitral stenosis discovered during the hospitalization. Following an initial emergent mechanical circulatory support with femoro-femoral extracorporeal life support (ECLS), the patient had the mitral ...
Packer Milton M Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX - - 2014
-Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs on the risk of clinical deterioration in surviving patients. -We compared the angiotensin-neprilysin inhibitor LCZ696 (400 mg daily) with ...
Braunwald Eugene E TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: - - 2014
Heart failure is a global problem with an estimated prevalence of 38 million patients worldwide, a number that is increasing with the ageing of the population. It is the most common diagnosis in patients aged 65 years or older admitted to hospital and in high-income nations. Despite some progress, the ...
Pouleur Anne-Catherine AC Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain and Division of Cardiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Electronic address: - - 2014
While there have been significant recent advances in the medical management of chronic HF (including the use of beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and aldosterone blockers), the ability to characterize, monitor, and predict a patient's response to HF therapy is poor. Risk stratification is important in patients ...
Mavroudis Constantine C Johns Hopkins Children's Heart Surgery, Florida Hospital for Children, Orlando, Florida. Electronic address: - - 2014
Specific congenital heart anomalies significantly increase the risk for late atrial arrhythmias, raising the question whether prophylactic arrhythmia operations should be incorporated into reparative open heart procedures. Currently no consensus exists regarding standard prophylactic arrhythmia procedures. Questions remain concerning the arrhythmia-specific lesions to perform, energy sources to use, need for ...
Germer Carina M CM Centro de Engenharia Biomédica, UNICAMP, R. Alexander Fleming 163, Cid. Universitária Zeferino Vaz, Campinas, SP, 13083-881, - - 2014
The electrocardiogram (ECG) is the simplest and most effective non-invasive method to assess the electrical activity of the heart and to obtain information on the heart rate (HR) and rhythm. Because information on the HR of very small reptiles (body mass <10 g) is still scarce in the literature, in the ...
Ong Sang-Bing SB Hatter Cardiovascular Institute, Institute of Cardiovascular Science, NIHR University College London Hospitals Biomedical Research Centre, University College London Hospital & Medical School, 67 Chenies Mews, London WC1E 6HX, - - 2014
Ischemic heart disease (IHD) remains the leading cause of death and disability worldwide. For patients presenting with an acute myocardial infarction, the most effective treatment for limiting myocardial infarct (MI) size is timely reperfusion. However, in addition to the injury incurred during acute myocardial ischemia, the process of reperfusion can ...
Moreno Nuno N Departamento de Fisiologia e Cirurgia Cardiotorácica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Electronic address: - - 2014
Levosimendan is a pyridazinone-dinitrile derivative with positive inotropic and vasodilatory effects that has beneficial effects on myocardial performance. In previous randomized studies levosimendan improved hemodynamics and clinical course, but its effect on prognosis is still unclear. This important issue has limited its use. Although primarily used in the management of ...
Selzman Craig H CH Division of Cardiothoracic Surgery, University of Utah School of Medicine, Salt Lake City, Utah. Electronic address: - - 2014
Ventricular assist devices have become standard therapy for patients with advanced heart failure either as a bridge to transplantation or destination therapy. Despite the functional and biologic evidence of reverse cardiac remodeling, few patients actually proceed to myocardial recovery, and even fewer to the point of having their device explanted. ...
Abbate Antonio A VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA; Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: - - 2014
Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome of exercise intolerance and/or congestion, in the presence of a left ventricular (LV) ejection fraction within the normal limits (i.e. LVEF>50%). Determining the presence of impaired LV relaxation and/or filling (diastolic dysfunction) in HFpEF is needed to pragmatically ...
Qiu Qiong Q Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yanjiang Road, Guangzhou, 510120, - - 2014
Left ventricular noncompaction (LVNC) is a rare cardiomyopathy with high incidence of heart failure (HF). It is unclear whether LVNC patients with desynchronized HF would benefit from cardiac resynchronization therapy (CRT). In order to evaluate the effect of CRT on LVNC, this study explored left ventricular (LV) remodeling and mechanical ...
Grotenhuis Heynric B HB Labatt Family Heart Center, Hospital for Sick Children, The University of Toronto, Toronto, Ontario, - - 2014
Echocardiography is the first-line diagnostic technique in patients with congenital heart disease. Recent developments include further standardization of pediatric and congenital echocardiography with general-specific and lesion-specific guidelines. New research focuses on clinical validation of echocardiographic quantitative techniques for assessing right ventricular and single ventricular function. Recent guidelines include standardization of ...
Clifton Peter P University of South Australia, Adelaide, South Australia, Australia. Electronic address: - - 2014
Although recent reports suggest an association between saxagliptin and an increased risk of admissions for heart failure, it is not clear whether dipeptidyl peptidase IV (DPP-IV) inhibition contributes to heart failure in high-risk patients. The purpose of this research is to understand heart failure risk among high-risk patients with type ...
Pisarenko Oleg I OI Russian Cardiology Research and Production Complex, Moscow, Russia. Electronic address: - - 2014
C-terminal fragments of adipokine apelin are able to attenuate myocardial ischemia-reperfusion (I/R) injury, but whether their effects are manifested during cardioplegic arrest remain obscure. This study was designed to evaluate the efficacy of natural apelin-12 (H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH, A12) and its novel structural analogs (H-(N(α)Me)Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Nle-Pro-Phe-OH, AI, and N(G)-Arg(N(G)NO2)-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Nle-Pro-Phe-NH2, AII) as additives to ...
Abbate Antonio A VCU Pauley Heart Center and Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, Virginia. Electronic address: - - 2014
Two pilot studies of interleukin-1 (IL-1) blockade in ST-segment elevation myocardial infarction (STEMI) showed blunted acute inflammatory response and overall favorable outcomes at 3 months follow-up. We hereby present a patient-level pooled analysis with extended follow-up of 40 patients with clinically stable STEMI randomized to anakinra, a recombinant IL-1 receptor antagonist, ...
- - 2014
Essential facts Each year, 175,000 people in the UK experience a myocardial infarction, or heart attack. This happens when the heart muscle is starved of oxygen-rich blood, causing damage to the muscle. Most heart attacks are caused by coronary heart disease (CHD), when the coronary arteries become narrowed by a ...
Chatterjee Neal N Massachusetts General Hospital, Harvard Medical School, Boston, - - 2014
Heart failure with preserved left ventricular (LV) ejection fraction (HFpEF) represents approximately half of patients with heart failure and confers similar morbidity and mortality as HF with reduced left ventricular ejection fraction (HFrEF).(1) HFpEF has been characterized by abnormal LV diastolic function, abnormal LV-central vascular coupling, impaired systolic reserve and ...
Peng Tao T Department of Nephrology, Shandong University Qilu Hospital, Jinan 250012, - - 2014
Background/Aims: To investigate the role of endothelial dysfunction on left ventricular remodeling in patients with chronic kidney disease and to evaluate the correlation between endothelial dysfunction and left ventricular remodeling. Methods: Seventy-three patients with chronic kidney disease as study-group and thirty healthy volunteers as control-group were enrolled in the present ...
Ahmad Tariq T Division of Cardiology, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Duke University Medical Center, Durham, North - - 2014
The purpose of this study was to examine changes in a broad panel of biomarkers following left ventricular assist device (LVAD) support in advanced heart failure (HF). LVAD therapy mechanically unloads the failing heart and may result in reversal of certain aspects of the end-stage HF phenotype. Changes in markers ...
Piper Susan E SE Department of Cardiovascular Research, King's College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, United Kingdom; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, United Kingdom. Electronic address: - - 2014
Soluble ST2 (sST2) is an emerging biomarker of cardiac remodelling and fibrosis. Studies indicate that it is predictive of mortality in acutely decompensated heart failure. The role of sST2 in chronic heart failure (CHF) is less well defined. No studies have examined serial measurements in optimised patients as a potential ...
Harring Gesa G University Heart Center Hamburg, Department of Pediatric Cardiology, University Hospital Hamburg- Eppendorf, Martinistrasse 52, 20246 Hamburg, - - 2014
Pentalogy of Cantrell (P.o.C.) is a rare congenital midline defect. We present a case and its treatment of P.o.C. with complete ectopia cordis and congenital heart disease. Postnatally the congenital heart defect was surgically corrected and the ectopic heart was covered by musculous mobilized flap. Due to cephalic orientation of ...
Seeger Joost Ph JP Department of Physiology, Radboud University Medical Centre, Nijmegen, The Netherlands Department of Pharmacology-Toxicology, Radboud University Medical Centre, Nijmegen, The - - 2014
Reperfusion is mandatory after ischaemia, but it also triggers ischaemia-reperfusion (IR)-injury. It is currently unknown whether heart failure alters the magnitude of IR-injury. Ischaemic preconditioning can limit IR-injury. Since ischaemic preconditioning is typically applied in subjects at risk for cardiovascular complications, it is of clinical importance to understand its efficacy ...
Halbach Marcel M Department of Internal Medicine III, Heart Center, University of Cologne, Kerpener Str. 62, 50937 Cologne, - - 2014
Sympathovagal imbalance plays a major role in the progression of heart failure with reduced ejection fraction. Baroreflex activation therapy (BAT) by electrical stimulation of baroreceptors located at the carotid sinus can reduce sympathetic and increase parasympathetic tone. This review provides an overview on the concept of BAT in heart failure ...
Hu Jing J Department of Pharmacy, General Hospital of Lanzhou Command, PLA, Lanzhou, 730050, China, - - 2014
Apigenin (Api), a mainly bioactive component of Apium graveolens L. var. dulce DC. (a traditional Chinese medicinal herb), possesses a wide range of biological activities, including antioxidant effects. It also has been shown to associate with lower prevalence of cardiovascular diseases, but its mechanisms of action remain unclear. The aim ...
Stienen G J M GJ Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands, - - 2014
Heart failure is a multi-factorial progressive disease in which eventually the contractile performance of the heart is insufficient to meet the demands of the body, even at rest. A distinction can be made on the basis of the cause of the disease in genetic and acquired heart failure and at ...
Gerdes A Martin AM New York College of Osteopathic Medicine at New York Institute of Technology - - 2014
The link between low thyroid hormone (TH) function and heart failure (HF) is reviewed. The idea that TH dysfunction may contribute to diseases leading to HF has been discussed for over 60 years. A growing body of evidence from animal and human studies, particularly in recent years, suggests that TH ...
Imamura Teruhiko T Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, University of - - 2014
Background:Predicting the occurrence of aortic insufficiency (AI) during left ventricular assist device (LVAD) support has remained unsolved.Methods and Results:We enrolled 52 patients who had received continuous flow LVAD (14 axial and 38 centrifugal pumps) and who been followed for ≥6 months between Jun 2006 and Dec 2013. Native aortic valve (AV) opening ...
Ueland Thor T Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet; Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: - - 2014
The extracellular matrix (ECM) plays an important role in left ventricular remodeling and progression of heart failure (HF). Biglycan and mimecan are ECM proteins that are abundantly expressed in cardiac tissue but have not been evaluated as prognostic markers in HF. We investigated their interaction with statin treatment and association ...
Swager Sarah A SA Dept. of Molecular & Cellular Biochemistry, Wexner Medical Center, The Ohio State University, Columbus, OH - - 2014
Claudin-5 is transcriptionally downregulated resulting in dramatically reduced protein levels in human heart failure. Studies in mice have demonstrated that reduced claudin-5 levels occur prior to cardiac damage and far before reduced whole heart function. Therefore, claudin-5 may be a useful early therapeutic target for human heart failure. However, the ...
Fresiello Libera L Institute of Clinical Physiology, Section of Rome, National Research Council, Rome, - - 2014
The current use of left ventricular assist devices (LVADs) as destination therapy is associated with the clinical need of monitoring patient-pump interaction. To this aim, the present work investigated the possibility of getting useful information about the status of the assisted left ventricle using electrocardiographic (ECG) data. A total of ...
Tsioufis Costas C aFirst Cardiology Clinic, University of Athens, Hippocration Hospital, Athens, Greece bVeterans Affairs and Georgetown University Medical Centers, Washington, District of Columbia cSt. Jude Medical, Inc., Irvine, California, USA dClinica Medica, University of Milano-Bicocca, Monza eIstituto di Ricerche a Carattere Scientifico IRCCS Multimedica, Sesto San Giovanni Milan, - - 2014
This EnligHTN I nonrandomized substudy investigated the effect of multielectrode renal denervation (RDN) on cardiac and neurohumoral adaptations. Eighteen patients with true drug-resistant hypertension [age: 56 ± 10 years, 12 men, BMI: 33.6 ± 5.4 kg/m, office blood pressure (BP) by automatic device (Omron): 182 ± 19/97 ± 18 mmHg and ambulatory BP (Spacelabs): 153 ± 16/87 ± 15 mmHg receiving 4.5 antihypertensive drugs/day] and ...
Rodríguez-Sinovas Antonio A Laboratorio de Cardiología Experimental, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain antonio.rodriguez.sinovas@vhir.org - - 2014
Microtubules play a major role in transmitting mechanical forces within the myocardium, and in maintaining organelle function. However, this intracellular network is disrupted during myocardial ischemia/reperfusion. We assessed the effects of prevention of microtubule disruption with paclitaxel on ischemia/reperfusion injury in isolated rat cardiomyocytes and hearts. Isolated rat cardiomyocytes were ...
Abend Alon A The Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, POB 9649, Haifa 31096, - - 2014
Heart failure is a major public health problem in western society. Recently, agents that inhibit histone deacetylase (HDAC) enzymes were developed and approved by the FDA as anticancer agents. This breakthrough has provided the motivation to develop more potent and more selective HDAC inhibitors and to target other pathologic conditions ...
Saito Shunsuke S Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan, - - 2014
Myocardial recovery occurs in a small cohort of patients receiving left ventricular assist device (LVAD) support, but identification of candidates for device removal remains challenging. We hypothesized that hemodynamic evaluation using echocardiography and right heart catheter during temporary suspension of LVAD support (LVAD-off test) can assess cardiac recovery to predict ...
Cheng Min M State Key Laboratory of Cardiovascular Disease, Department of Evidence Based Medicine, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beili Shi Road 167, Beijing, - - 2014
The prognostic significance of atrial fibrillation (AF) in patients with heart failure remains inconclusive. To perform a meta-analysis of the published data to study the prognostic significance of AF in heart failure patients and to determine whether this relates to the presence of preserved or reduced left ventricular systolic function. ...
Broch Kaspar K Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; K. G. Jebsen Research Centre and Center for Heart Failure Research, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: - - 2014
Elevated levels of soluble ST2 (sST2) are associated with adverse outcome in heart failure. A change in sST2 levels has also been shown to presage outcome. In vitro, ST2 expression is induced by myocardial stress and pro-inflammatory stimuli. The determinants of sST2 levels in vivo, and how they vary with ...
Goretti Emeline E Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé (CRP-Santé), 84 Val Fleuri, L-1526 Luxembourg, - - 2014
miRNAs are small noncoding RNAs known to post-transcriptionally regulate gene expression. miRNAs are expressed in the heart where they regulate multiple pathophysiological processes. The discovery of stable cardiac miRNAs in the bloodstream has also motivated the investigation of their potential as biomarkers. This review gathers the current knowledge on the ...
Fabregat-Andrés Oscar O Servicio de Cardiología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain; Fundación de Investigación, Hospital General de Valencia, Valencia, Spain. Electronic address: - - 2014
Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a metabolic regulator induced during ischemia that prevents cardiac remodeling in animal models. The activity of PGC-1α can be estimated in patients with ST-segment elevation acute myocardial infarction. The aim of the present study was to evaluate the value of blood PGC-1α ...
Finsterer Josef J Krankenanstalt Rudolfstiftung, Vienna, Austria. Electronic address: - - 2014
One of the most frequently affected organs in mitochondrial disorders (MIDs), defined as hereditary diseases due to affection of the mitochondrial energy metabolism, is the heart. Cardiac involvement (CI) in MIDs has therapeutic and prognostic implications. This review aims at summarizing and discussing the various cardiac manifestations in MIDs. Data ...
Rossignol Patrick P Inserm, Centre d'Investigations Cliniques-Plurithématique 1433, Inserm U1116, Nancy, France; CHU Nancy, Département de Cardiologie, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France; Université de Lorraine, France; INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), France. Electronic address: - - 2014
Numerous registries, including the most recent ESC Euro-observational registry, have reported a large and persistent gap between real-life practice in the use of life-saving evidence-based therapies (such as renin angiotensin antagonists, beta-blockers, mineralocorticoid receptor antagonists) and recommended practices in international guidelines. Although the use of multiple renin angiotensin aldosterone system-inhibitors ...
Wroński Jakub J Students Scientific Group at Department of Pathology, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warszawa, Poland; Students Scientific Group at Department of General and Transplantation Surgery, Medical University of Warsaw, Nowogrodzka 59, 02-006 Warszawa, Poland. Electronic address: - - 2014
Cirrhotic cardiomyopathy is a chronic cardiac dysfunction in patients with liver cirrhosis. It is mostly characterized by impaired cardiac function, but some myocardial anatomical changes have also been described. The aim of this study was to assess the influence of liver cirrhosis on heart wall thickness changes in a retrospective ...
Lankford Harvey V HV 1 Richmond, - - 2014
Abstract Lankford, Harvey V, Erik R Swenson. Dilated hearts at high altitude: Words from on high. High Alt Med Biol 15:000-000, 2014.-From the time of the turn of the twentieth century, dilated hearts and presumed cardiac fatigue in expeditionary climbers and scientists have been the subject of much commentary in ...
Gigliotti Osvaldo S OS Seton Heart Institute, Austin, - - 2014
The rationale to perform left ventriculography at the time of cardiac catheterization has been little studied. The technique and frequency of use of left ventriculography vary by geographic regions, institutions, and individuals. Despite the recent publication of guidelines and appropriate use criteria for coronary angiography, revascularization, and noninvasive imaging, to ...
Masuda Mio M Department of Metabolism, Endocrinology, Molecular Medicine, and Nephrology, Osaka City University Graduate School of Medicine, Osaka, - - 2014
Background/Aims: β2-Microglobulin (β2-MG) is a major protein component of dialysis-related amyloidosis. In long-term hemodialysis (HD) patients, β2-MG amyloid deposits not only in osteoarticular tissues, but also in systemic tissues, including the heart. The purpose of this study was to investigate the relationship between serum β2-MG concentrations and echocardiographic parameters in ...
1 2 3 4 5 6 7 8 9 10 >