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Pettit Mark A MA Emergency Medicine Resident Physician (Pettit), *Department of Emergency Medicine, Christiana Care Health System, Newark, DE; Emergency Medicine Attending Physician, Assistant Professor of Emergency Medicine (Koyfman), †Division of Emergency Medicine, University of Illinois College of Medicine at Peoria, OSF Saint Francis Medical Center, Peoria, IL; and Emergency Medicine Attending Physician, Assistant Professor of Emergency Medicine (Foran), ‡Department of Emergency Medicine, NYU School of Medicine, Bellevue Hospital Center, New York, - - 2014
Myocarditis is an inflammatory disease of the heart that can cause devastating disease in otherwise healthy children. Inciting agents such as viral infection cause direct damage to the myocardial cells, which triggers an inflammatory response that enhances myocardial toxicity and associated morbidity. Severe cases typically present with respiratory distress and ...
Cheung Yiu-Fai YF Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China. Email: - - 2014
This review aims to provide an overview of conventional and novel indices used in clinical and research arenas for evaluation of right ventricular (RV) function in congenital heart diseases with a dual-chambered circulation. Articles cited in this review were selected using PubMed search of publications in English with no date ...
Lin Elaine Y EY Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, - - 2014
Adults with congenital heart disease (CHD) face increased risk for morbidity and mortality with age, but few prognostic models exist. This study aims to assess whether the Heart Failure Survival Score (HFSS), which risk stratifies patients for heart transplantation, predicts outcomes in adults with moderate or complex CHD. This was ...
Lambiase Pier D PD Institute of Cardiovascular Science, Heart Hospital, UCL, 16-18 Westmoreland Street, London, W1G 8PH, UK, - - 2014
Connexins are essential in the propagation of electrical activity throughout the heart and are an important determinant of conduction velocity. Their dysfunction is an important factor in the genesis of abnormal cardiac rhythm and is relevant to the pathogenesis of a wide variety of cardiac pathologies. Here, we review the ...
Lee Hae-Young HY Department of Internal Medicine, Seoul National University Hospital, Seoul, - - 2014
This study was designed to evaluate the dose-effect relationship of statins in patients with ischemic congestive heart failure (CHF), since the role of statins in CHF remains unclear. The South koreAn Pitavastatin Heart FaIluRE (SAPHIRE) study was designed to randomize patients with ischemic CHF into daily treatments of 10 mg ...
Prastaro Maria M Department of Advanced Biomedical Sciences, Federico II University, Via Pansini, 5, 80131, Naples, Italy, - - 2014
Heart failure with reduced ejection fraction is a common and malignant condition, which recognizes a lot of causes and that carries a poor long-term prognosis. All patients with reduced left ventricular ejection fraction, both asymptomatic and symptomatic, should be evaluated with transthoracic echocardiography as a depth analysis of first level, ...
Goshvarpour Atefeh - - 2014
Background: Poincare plots are commonly used to study the nonlinear behavior of physiologic signals. The aim of this study is to evaluate the Poincare plot indices of human heart rate signals during meditation. Methods: For this purpose, heart rate time series of eight Chi meditators available in Physionet database were ...
Buchner Stefan S Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany Both authors contributed equally - - 2014
Structural and functional integrity of the right heart is important in the prognosis after acute myocardial infarction (AMI). The objective of this study was to assess the impact of sleep disordered breathing (SDB) on structure and function of the right heart early after AMI. 54 patients underwent cardiovascular magnetic resonance ...
Hudzik Bartosz B Third Department of Cardiology, Silesian Centre for Heart Disease, Medical University of Silesia, Curie-Sklodowska 9, 41-800, Zabrze, Poland, - - 2014
Nowadays, amiodarone is the most commonly used antidysrhythmic drug in clinical practice. It is highly effective in the management of recurrent ventricular dysrhythmias, paroxysmal supraventricular dysrhythmias, including atrial fibrillation and flutter, and in the maintenance of sinus rhythm after electrical cardioversion of atrial fibrillation. Moreover, it has the added benefit ...
Nakao Yoko M YM Department of EBM Research, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, 54 Shogoinkawaharacho, Sakyo-Ku, Kyoto, 606-8507, - - 2014
It was previously reported that nocturnal home oxygen therapy (HOT) significantly improved not only sleep disordered breathing (SDB), but also quality of life (QOL) and left ventricular ejection fraction (LVEF) in two trials. To strengthen the statistical reliability of the above efficacies of HOT and to assess the effects of 12-week ...
Ferrari Markus M Clinic of Internal Medicine 1, HSK, Klinikum der Landeshauptstadt Wiesbaden und der HELIOS Kliniken Gruppe, Wiesbaden, - - 2014
Cardiogenic shock due to acute myocardial infarction, postcardiotomy syndrome following cardiac surgery, or manifestation of heart failure remains a clinical challenge with high mortality rates, despite ongoing advances in surgical techniques, widespread use of primary percutaneous interventions, and medical treatment. Clinicians have, therefore, turned to mechanical means of circulatory support. ...
Mancuso Frederico José Neves FJ Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, - - 2014
Background: Cardiovascular urgencies are frequent reasons for seeking medical care. Prompt and accurate medical diagnosis is critical to reduce the morbidity and mortality of these conditions. Objective: To evaluate the use of a pocket-size echocardiography in addition to clinical history and physical exam in a tertiary medical emergency care. Methods: ...
Muntean Danina M - - 2014
Ischemia and heart failure-related cardiac arrhythmias, both atrial (e.g., atrial fibrillation) and ventricular (e.g., malignant tachyarrhythmias) represent a leading cause of morbidity and mortality worldwide. Despite the progress made in the last decade in understanding their pathophysiological mechanisms there is still an unmet need for safer and more efficacious pharmacological ...
Mora Luis L Emory University Hospital, Atlanta, - - 2014
A 56-year-old man with a history of paroxysmal atrial fibrillation was referred for consideration of non-pharmacologic approaches to reduce stroke risk. He had been recently admitted to the hospital with an acute ischemic stroke thought to be cardioembolic in origin and had a history of prior traumatic subdural hematoma. Given ...
Frey Norbert N From the Universitätsklinikum Schleswig-Holstein, Campus Kiel Klinik für Kardiologie und Angiologie, Kiel, Germany (N.F., M.R.); Department of Internal Medicine/Cardiology, University of Leipzig, Heart Center, Leipzig, Germany (A.L.); Medizinische Klinik Kardiologie, Angiologie, Pneumologie Internische Intensivmedizin Hämostasiologie, Mannheim, Germany (T.S.); Department of Internal Medicine III, Heart Center, University of Cologne, Cologne, Germany (J.M.-E.); AZ Middelheim Cardiology, Antwerpen, Belgium (P.V.); UZ Brussel Department of Cardiology, Brussel, Jette, Belgium (D.S.); Medizinische Universitätsklinik (Krehl-Klinik) Abteilung Innere Medizin III, Kardiologie, Angiologie, und Pneumologie, Heidelberg, Germany (F.B.); BioLineRx, Jerusalem, Israel (S.T.); Neufeld Cardiac Research Institute, Tel-Aviv University, Tamman Cardiovascular Research Institute, Regenerative Medicine, Stem Cells and Tissue Engineering Center, Sheba Medical Center, Tel-Hashomer, Israel - - 2014
We aimed to test, for the first time, the feasibility of intracoronary delivery of an innovative, injectable bioabsorbable scaffold (IK-5001), to prevent or reverse adverse left ventricular remodeling and dysfunction in patients after ST-segment-elevation myocardial infarction. Patients (n=27) with moderate-to-large ST-segment-elevation myocardial infarctions, after successful revascularization, were enrolled. Two milliliters ...
Iles Leah M LM Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia Baker IDI Heart and Diabetes Institute, Melbourne, Australia - - 2014
Myocardial fibrosis is fundamental in the pathogenesis of heart failure. Late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) imaging is commonly assumed to represent myocardial fibrosis; however, comparative human histological data are limited, especially in non-ischaemic cardiac disease. Diffuse interstitial myocardial fibrosis is increasingly recognized as central in the ...
Rienzo Mario M From the Inserm, U955, Equipe 03, F-94000, Créteil, France (M.R., J.M., A.B., L.S., M.J., J.B.S., L.H., A.B., B.G.); Université Paris-Est, UMR_S955, UPEC, F-94000, Créteil, France (M.R., J.M., A.B., L.S., M.J., J.B.S., L.H., A.B., B.G.); Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, F-94700, Maisons-Alfort, France (M.R., J.M., A.B., L.S., M.J., J.B.S., L.H., A.B., B.G.); AP-HP, Groupe Hospitalier Henri Mondor, Fédération de Cardiologie, F-94000, Créteil, France (L.H., A.B.); and AP-HP, Hôpital Européen Georges Pompidou, Service d'Anesthésie-Réanimation Chirurgicale, F-75015, Paris, France - - 2014
During chronic hypertension, increases in heart rate (HR) or adrenergic stimulation are associated with maladaptive left ventricular responses as isovolumic contraction and relaxation durations failed to reduce, impeding filling. We, therefore, investigated the effects of acute selective HR reduction with ivabradine on left ventricular dysfunction during chronic hypertension. Accordingly, chronically ...
Deshpande Alok A Alok Deshpande, Yochai Birnbaum, The Section of Cardiology, The Department of Medicine, Baylor College of Medicine, Houston, TX 77030, United - - 2014
The benefits of early perfusion in ST elevation myocardial infarctions (STEMI) are established; however, early perfusion of non-ST elevation myocardial infarctions has not been shown to be beneficial. In addition, ST elevation (STE) caused by conditions other than acute ischemia is common. Non-ischemic STE may be confused as STEMI, but ...
Hutchinson Lisa J LJ Bristol Royal Hospital for Children,Bristol,United - - 2014
The Medtronic LINQ™ was inserted in an 11-month-old boy for close monitoring of rapid ventricular tachycardia. The device is much smaller than the conventional Medtronic loop recorder. The real advantage of the LINQ™ is that it automatically notifies Carelink if any ventricular tachycardia is seen, which is very advantageous for ...
Lindbäck Camilla C School of Health, Care and Social Welfare, Mälardalen University , Eskilstuna/Västerås , Sweden - - 2014
Abstract Purpose: The aim of the present study was to explore and describe meanings of being on sick leave due to heart failure. Methods: The study was conducted in Sweden during 2011-2012. Five men and one woman, aged 46 to 62, were interviewed. A reflective life-world research approach based on ...
Takeishi Yasuchika Y Department of Cardiology and Hematology, Fukushima Medical - - 2014
Appropriate use of biomarkers is clinically important for identifying heart failure in its early stage, optimizing risk stratification, and managing patients. This article describes established and traditional biomarkers as well as novel biomarkers reflective of myocardial stress, myocardial damage, extracellular matrix, oxidative stress, inflammation, renal function, micro RNAs, and heart ...
Herring Neil N Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK - - 2014
Acute myocardial infarction and congestive cardiac failure are characterized by high levels of cardiac sympathetic drive. Under these conditions additional sympathetic neurotransmitters such as neuropeptide-Y can be released in addition to norepinephrine and plasma levels correlate with infarct size and mortality. Even in the presence of beta-blockers, NPY is able ...
Arnous Samer S Manchester Heart Centre, Manchester Royal Infirmary, Biomedical Research Centre, Manchester, United - - 2014
Aims: The aim of this study was to assess the safety and feasibility of manual removal of a non-occlusive coronary thrombus using an open filter device. Between April 2006 and December 2011, 1,102 patients were treated percutaneously for acute coronary syndrome at our institution. Of these, nine (1%) had a ...
Imamura Teruhiko T Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, - - 2014
Although the suppression of sympathetic activity is an essential mission for the current heart failure treatment strategy, little is known about the relationship between the rotation speed setting and autonomic nervous activity during continuous-flow left ventricular assist device (LVAD) treatment. We evaluated 23 adult patients with sinus rhythm (36 ± 13 years) who ...
Søndergaard Eva Bjerre - - 2014
Abstract Objectives: The objective of the study was to analyse the outcome of patients with advanced heart failure due to abuse of anabolic-androgenic steroids. Design: A retrospective chart review of patients admitted or referred for advanced heart failure, due to anabolic androgenic steroid abuse, in the period 2009 to 2013 ...
Okin Peter M PM aGreenberg Division of Cardiology, Weill Cornell Medical College, New York, New York, USA bGlostrup University Hospital, Copenhagen, Denmark cUniversity of Bergen, Bergen, Norway dSahlgrenska University Hospital/Östra, Gothenburg, - - 2014
Persistence or development of ECG left ventricular hypertrophy (LVH) by Cornell product criteria is associated with an increased risk of developing heart failure compared with regression or continued absence of LVH. We postulated that this association might be in part mediated via worse left ventricular systolic function in patients with ...
Mahr Claudius C Division of Cardiology, University of Washington, Seattle, WA, 98195, - - 2014
Advanced heart failure describes the subset of heart failure patients refractory to conventional medical therapy. For some advanced heart failure patients, the use of mechanical circulatory support provides an intermediary "bridge" step for transplant eligible patients or an alternative therapy for transplant ineligible patients. Over the past 20 years, clinical ...
Osadchii Oleg E - - 2014
Abstract Objectives. In the clinical setting, patients with slower resting heart rate are less prone to cardiovascular death compared to those with elevated heart rate. However, electrophysiological adaptations associated with slowed cardiac rhythm have not been thoroughly explored. In this study, relationships between intrinsic heart rate and arrhythmic susceptibility were ...
Hacking Douglas F DF Department of Paediatric Intensive Care, The Royal Children's Hospital, Melbourne, Victoria, Australia; Department of Anaesthetics, Saint Vincent's Hospital, Melbourne, Victoria, - - 2014
We aimed to determine the effect of elective left heart decompression at the time of initiation of central venoarterial extracorporeal membrane oxygenation (VA ECMO) on VA ECMO duration and clinical outcomes in children in a single tertiary ECMO referral center with a large pediatric population from a national referral center ...
Kikuchi C C Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Anesthesiology, Asahikawa Medical University, Asahikawa, - - 2014
The pharmacological conditioning of the heart with anaesthetics such as volatile anaesthetics or opioids is a phenomenon whereby a transient exposure to an anaesthetic agent protects the heart from the harmful consequences of myocardial ischemia and reperfusion injury. The cellular and molecular mechanisms of anaesthetic conditioning appear largely to mimic ...
Paglia Antonella A Department of Translational Medical Sciences- Section of Internal Medicine, University of Naples Federico - - 2014
Central aortic pressure waveform (AoPW) is the summation of a forward-traveling wave generated by the left ventricle and a backward-traveling wave caused by the reflection of the forward wave. The aim of this study was to evaluate the effect of ventricular-vascular coupling on the morphology of AoPW in chronic heart ...
Coffin Samuel T ST Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, - - 2014
: Eosinophilic myocarditis is a rare condition in which inflammation of the heart results in an infiltrative cardiomyopathy that is often difficult to diagnose in the acute setting. It sometimes presents as left ventricular hypertrophy. The authors present a case of a 79-year-old woman with a history of Non-Hodgkin's lymphoma ...
Camer Danielle D School of Medicine, and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, - - 2014
Bardoxolone methyl has been reported to cause detrimental cardiovascular events in the terminated BEACON Phase III human clinical trial via modulation of the renal endothelin pathway. However, the effects of bardoxolone methyl administration on the endothelin pathway in the heart are unknown. Our purpose in this perspective is to highlight ...
Amundson Beret E - - 2014
Abstract Cardiac troponin (cTn) I and T are released from myocardial cells following necrosis, i.e., cell death. An accurate measure of cTn concentrations in a patient's blood following ischemia/chest pain can enable providers to determine whether or not a myocardial infarction (MI) has occurred. Point-of-care (POC) devices that measure blood ...
Diakos Nikolaos A NA Utah Transplantation Affiliated Hospitals (UTAH) Cardiac Transplant Program: Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health Sciences Center, Intermountain Medical Center, Veterans Administration Salt Lake City Health Care System, Salt Lake City, Utah; University of Utah Molecular Medicine Program, Salt Lake City, - - 2014
In animal models of heterotopic transplantation, mechanical unloading of the normal, nonhypertrophic heart results in atrophy. Primarily on the basis of these animal data, the notion that chronic left ventricular assist device (LVAD)-induced unloading will result in atrophy has dominated the clinical heart failure field, and anti-atrophic drugs have been used ...
Weinheimer Carla J CJ Center for Cardiovascular Research, Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri, United States of - - 2014
Mouse surgical models are important tools for evaluating mechanisms of human cardiac disease. The clinically relevant co-morbidities of hypertension and ischemia have not been explored in mice. We have developed a surgical approach that combines transverse aortic constriction (TAC) and distal left anterior coronary ligation (MI) to produce a gradual ...
Nagao Michinobu M Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu - - 2014
The aims of this study were to quantify the geometrical differences in left ventricular (LV) dyssynchrony in patients with heart failure (HF) using cine-tagged MRI, and to investigate the relationship between dyssynchrony and major adverse cardiac events (MACE) in HF.In 67 patients with HF [mean LV ejection fraction (LVEF), 34%], ...
Watanabe Atai A Institute of Medical Science, The University of - - 2014
Anticoagulants such as warfarin are recommended for patients with atrial fibrillation (AF) to decrease stroke risk associated with thrombus formation in the left atrium (LA). In a subgroup of patients, however, warfarin is unable to prevent LA thrombus formation at therapeutic doses. This study characterized the clinical and echocardiographic features ...
Sobanski Piotr P aHildegard Palliative Centre Basel bGynaecological Cancer Centre, University Hospital Basel, Basel, Switzerland cDepartment of Social and Welfare Studies, Linköping University, Linköping, Sweden dDepartment of Palliative Care, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, - - 2014
Until recently, concepts of care for people with heart failure had rarely included preparation for unavoidable imminent death or caring for the dying.The purpose of this review is to provide an update on current end-of-life issues specific to heart failure patients. Mortality in the heart failure population remains high, especially ...
Yu Jiangbo J Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. - - 2014
Matrine, an alkaloid isolated from the traditional Chinese medicine Sophora flavescens AIT has exhibited a number of therapeutic effects on cardiovascular and liver diseases. The purpose of the present study was to investigate whether matrine has a protective effect on heart failure in rats. Coronary artery ligation was used to ...
Hoyer Alexandro A Department of Cardiac Surgery, University of Leipzig, Heart Center Leipzig, Struempellstrasse 39, 04289, Leipzig, Germany, - - 2014
Evidence as to how ACE inhibitors attenuate ischemia-reperfusion injury (IR) after cardioplegic arrest remains scarce. Twenty-four rabbit hearts were perfused on a Langendorff apparatus. Control hearts (n = 6) were arrested with pure histidine-tryptophan-ketoglutarate (HTK)-Bretschneider. Treatment groups received added to the cardioplegic solution (n = 6) captopril (100 μmol/l) and losartan (100 μmol/l) for selective AT1-receptor ...
den Uil Corstiaan A CA Department of Cardiology, Erasmus Medical Center, Thoraxcenter, 's-Gravendijkwal 230, 3015, CE Rotterdam, The Netherlands, - - 2014
Intravenous nitroglycerin is a well-known, but underused, treatment for acute decompensated heart failure. Nitroglycerin has a rapid onset of action and short half-life and there is a clear dose-response curve on both global hemodynamics and peripheral circulation. IV nitroglycerin reduces LV and RV filling pressures and afterload. In the case ...
Hürlimann David D Department of Cardiology, Invasive Electrophysiology and Devices, University Heart Center Zurich, Zurich, - - 2014
Various studies have attempted to identify super-responders to cardiac resynchronization therapy (CRT) by echocardiographic parameters of reverse remodeling. However, scientific evidence regarding those parameters is scarce. This study aimed at validating the definition of super-response to CRT based on the following frequently employed echocardiographic parameters: left ventricular ejection fraction (LVEF), ...
Kydd Anna C AC Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, - - 2014
Optimal delivery of CRT requires appropriate patient selection and device implantation. Echocardiographic predictors of CRT response individually appear to enhance patient selection, but do not fully reflect the complex underlying myocardial dysfunction. We hypothesized that a multiparametric approach would offer greater predictive value and sought to derive a score incorporating ...
Li Jifen J Center for Translational Medicine, Thomas Jefferson - - 2014
Rationale: Shortly after birth, muscle cells of the mammalian heart lose their ability to divide. Thus, they are unable to effectively replace dying cells in the injured heart. The recent discovery that the transcriptional co-activator Yap is necessary and sufficient for cardiomyocyte proliferation has gained considerable attention. However, the upstream ...
Fox P R PR The Animal Medical Center, New York, - - 2014
Cardiac biomarkers provide objective data that augments clinical assessment of heart disease (HD). Determine the utility of plasma N-terminal pro-brain natriuretic peptide concentration [NT-proBNP] measured by a 2nd generation canine ELISA assay to discriminate cardiac from noncardiac respiratory distress and evaluate HD severity. Client-owned dogs (n = 291). Multicenter, cross-sectional, prospective investigation. ...
Zhang Wei W Pharmacy Department of Yulin First Hospital, Second Affiliated Hospital of Yanan University, Yulin Shaanxi, 719000, PR - - 2014
The present study was designed to investigate whether oxymatrine could attenuate isoproterenol-induced heart failure via regulation of asymmetric dimethylarginine (ADMA) metabolism in rats. Heart failure model was established by once daily subcutaneous injection of isoproterenol (5mg/kg/d) to rats for 7 days. Simultaneously, oral administration of oxymatrine (25, 50 and 100mg/kg/d, ...
Smith Daryl I DI 1 Department of Anesthesiology, 2Division of Cardiac Surgery, 3Division of Thoracic and Foregut Surgery, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 604, Rochester, NY - - 2014
Stellate ganglion blockade for cardiac dysrhythmia is a well described but infrequently used technique to manage ventricular tachycardia (VT). In patients with left ventricular assist devices (LVAD), these dysrhythmias cause increased morbidity because of right ventricular dysfunction, and often severe discomfort. Continuous stellate ganglion blockade may yield valuable information on ...
Chin Melanie P MP Reata Pharmaceuticals, Irving, TX, - - 2014
A phase 3 randomized clinical trial was designed to test whether bardoxolone methyl, a nuclear factor-erythroid-2-related factor-2 (Nrf2) activator, slows progression to end-stage renal disease in patients with stage 4 chronic kidney disease and type 2 diabetes mellitus. The trial was terminated because of an increase in heart failure in ...
Toldo Stefano S VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA; Victoria Johnson Research Laboratory, Virginia Commonwealth University, Richmond, VA, - - 2014
Impairment in the myocardial relaxation and/or of the ventricular compliance determines the presence of diastolic dysfunction. Diastolic dysfunction in the heart may occur as a result of normal aging, but it more often is caused by metabolic or structural abnormalities in the myocardium, which are the substrate for diastolic heart ...
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