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Mc Ardle Brian A BA Department of Medicine (Division of Cardiology), University of Ottawa Heart Institute, Ottawa, Canada; National Cardiac PET Center, University of Ottawa Heart Institute, Ottawa, - - 2014
-Cardiac Allograft Vasculopathy (CAV) is a key prognostic determinant following heart transplant (HT). Detection and risk stratification of patients with CAV is problematic. Positron emission tomography (PET) using Rubidium-82 (Rb-82) allows quantification of absolute myocardial blood flow and may have utility for risk stratification in this population. -Patients with a ...
Bajaj Sharad S Departments of 1Cardiovascular Diseases and 2Electrophysiology, St. Michael's Medical Center, Newark, - - 2014
Brugada syndrome predisposes individuals to ventricular arrhythmias and sudden cardiac death, in the absence of structural heart disease. The typical Brugada electrocardiogram (ECG) phenotype is often concealed in affected population, and the existing genetic testing is capable of detecting just about 20% of cases. Therefore, the diagnosis largely requires various ...
Kotecha Dipak D University of Birmingham Centre for Cardiovascular Sciences, Birmingham, UK; Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust, London, UK; Centre of Cardiovascular Research and Education in Therapeutics, Monash University, Melbourne, VIC, Australia. Electronic address: - - 2014
Atrial fibrillation and heart failure often coexist, causing substantial cardiovascular morbidity and mortality. β blockers are indicated in patients with symptomatic heart failure with reduced ejection fraction; however, the efficacy of these drugs in patients with concomitant atrial fibrillation is uncertain. We therefore meta-analysed individual-patient data to assess the efficacy ...
Mart Christopher Robin CR Division of Pediatric Cardiology, Department of Pediatrics, Primary Children's Hospital, University of Utah, 100 North Mario Capecchi Drive, Salt Lake, UT, 84113, USA, - - 2014
Neonates born with borderline left heart hypoplasia, or hypoplastic left heart complex, can undergo biventricular repair while those with severe left heart hypoplasia require single ventricle palliation. Deciding which patients are candidates for biventricular repair may be very difficult since there are no scoring systems to predict biventricular repair in ...
Elgendy Islam Y IY 1600 SW Archer Road, PO Box 100277 Gainesville, FL. 32610. - - 2014
Beta-adrenergic blockers remain one of the cornerstones in the management of coronary artery disease, both in chronic stable angina and myocardial infarction. These recommendations were based on studies conducted in the era prior to the establishment of the modern therapy for ischemic heart disease and myocardial infarction i.e. anti-platelet therapy, ...
Sanborn Timothy A TA NorthShore University HealthSystem, Evanston, IL, - - 2014
Objective: To assess the relationship of femoral vascular closure device (VCD) use to bleeding and ischemic events in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) via different anticoagulation strategies. Background: It is unknown whether femoral VCD reduce major bleeding after primary PCI for STEMI ...
Tchantchaleishvili Vakhtang V Division of Cardiac Surgery, University of Rochester Medical Center, Rochester, USA - - 2014
Transcatheter device closure of atrial septal defects (ASDs) is a minimally invasive technique that offers an alternative to conventional surgical repair. There are risks imposed by this technique; however, they compare favourably with risks of surgical closure. Here, we present a case of a 59-year old male with late erosion ...
Hayward Robert M RM Division of Cardiology, Department of Medicine, University of California, San - - 2014
Late after surgical repair of complex congenital heart disease, atrial arrhythmias are a major cause of morbidity, and ventricular arrhythmias and sudden cardiac death are a major cause of mortality. The six cases in this article highlight common challenges in the management of arrhythmias in the adult congenital heart disease ...
Zannad Faiez F Inserm, CIC 1433, Centre Hospitalier Universitaire, Department of Cardiology, Nancy University, Université de Lorraine, Nancy, France - - 2014
The neural cardiac therapy for heart failure (NECTAR-HF) was a randomized sham-controlled trial designed to evaluate whether a single dose of vagal nerve stimulation (VNS) would attenuate cardiac remodelling, improve cardiac function and increase exercise capacity in symptomatic heart failure patients with severe left ventricular (LV) systolic dysfunction despite guideline ...
Fox Kim K From the National Heart and Lung Institute, Imperial College, Institute of Cardiovascular Medicine and Science, Royal Brompton Hospital, London (K.F., P.G.S.), and the Robertson Centre for Biostatistics, University of Glasgow, Glasgow (I.F.) - both in the United Kingdom; Département Hospitalo-Universitaire Fibrosis Inflammation Remodeling, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, INSERM Unité 1148, and Université Paris-Diderot, Sorbonne Paris Cité - all in Paris (P.G.S.); the Montreal Heart Institute Coordinating Centre, Université de Montréal, Montreal (J.-C.T.); the Third Division of Cardiology, Medical University of Silesia, Katowice, Poland (M.T.); and the Department of Cardiology and Laboratory for Technologies of Advanced Therapies Center, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care and Research, Ettore Sansavini Health Science Foundation, Cotignola, Italy - - 2014
Background An elevated heart rate is an established marker of cardiovascular risk. Previous analyses have suggested that ivabradine, a heart-rate-reducing agent, may improve outcomes in patients with stable coronary artery disease, left ventricular dysfunction, and a heart rate of 70 beats per minute or more. Methods We conducted a randomized, ...
Imbrogno S S Dept. of Biology, Ecology and Earth Sciences (B.E.ST), University of Calabria, Arcavacata di Rende (CS), Italy. Electronic address: - - 2014
Goldfish tolerate prolonged and severe hypoxia, thus representing a well-suited model to study the maintenance of cardiac function when O2 availability represents a limiting factor. Using a working heart preparation, we explored the role of the intracardiac nitric oxide synthase (NOS)-derived Nitric Oxide (NO) under normoxic and hypoxic conditions. Cardiac ...
Abe Hajime H Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Department of Cardiology, Sakakibara Heart Institute, 3-16-1 Asahicho, Fuchu-shi, Tokyo 183-0003, Japan. Electronic address: - - 2014
Detecting the presence of coronary artery disease (CAD) is critically important in managing patients with heart failure of uncertain cause. The recently introduced (123)I-BMIPP/(201)TlCl dual myocardial single-photon emission computed tomography (dual SPECT) is potentially a non-invasive diagnostic tool in detecting ischemic heart disease. The aim of our study is to ...
Li Mengmeng M State Key Laboratory of Reproductive Medicine, Department of Pediatrics, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, - - 2014
Polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants that may pose significant health-risks to various organisms including humans. Although the mixed PCB Aroclor 1254 is widespread in the environment, its potential toxic effect on heart development and the mechanism underlying its developmental toxicity have not been previously studied. Here, we used ...
Huang Bing B Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, P.R. - - 2014
Recently, a beneficial effect of renal sympathetic denervation (RSD) has been seen in patients with ventricular electrical storm. However, the effect of RSD on ventricular electrophysiology remains unclear. Thirty-three mongrel dogs were included in the present study. RSD was performed by radiofrequency ablation of the adventitial surface of the renal ...
Fang Jie J Department of Orthodontics, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, - - 2014
Molecular switches of myosin isoforms are known to occur in various conditions. Here, we demonstrated the result from fetal heart failure and its potential mechanisms. Fetal and adult heart failure rat models were induced by injections of isoproterenol as previously described, and Go6976 was given to heart failing fetuses. Real-time ...
Malakan Rad Elaheh E Section of Pediatric Cardiology, Children's Medical Center (Pediatric Center of Excellence), Tehran University of Medical Sciences, Tehran, - - 2014
Congenital left ventricular outpouchings (LVOs) are reported under five overlapping and poorly defined terms including left ventricular accessory chamber, left ventricular aneurysm (LVA), left ventricular diverticulum (LVD), double-chambered LV, and accessory left ventricle. Diagnostic criteria are frequently mixed and not mutually exclusive. They convey no information regarding treatment strategy and ...
Nagao Michinobu M Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, - - 2014
Right ventricular (RV) failure and ventricular dyssynchrony are strong determinants of prognosis in patients with adult congenital heart disease (ACHD). The aim of this study was to investigate the relationship between interventricular dyssynchrony (IVD) using cine-tagged magnetic resonance imaging (MRI) and RV dysfunction in ACHD patients. Sixty-seven patients with ACHD ...
Korkmaz K K Department of Cardiovascular Surgery, Ankara Numune sResearch and Training Hospital, Ankara, Turkey. - - 2014
Left ventricular pseudo-aneurysms develop when cardiac rupture is contained by pericardial adhesions or scar tissue due to myocardial infarction, surgery, trauma or infection. Left ventricular pseudo-aneurysms are uncommon, difficult to diagnose and prone to cardiac rupture. Urgent surgical repair is recommended. Here we report on a case of a large ...
Haworth Thomas Eliot TE University of - - 2014
To extend our knowledge of fish cardiac excitability to a Chondrostei fish, we examined electrophysiological phenotype of the Siberian sturgeon (Acipenser baerii) heart. Epicardial ECG of A.baerii had typical waveform of vertebrate ECG with Q-T interval of 650 ± 30 ms and an intrinsic heart rate of 45.5 ± 5 ...
Tomson Todd T TT Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, 676 North St. Claire, Suite 600, Chicago, IL 60611, - - 2014
Insertable cardiac monitors (ICMs) are leadless subcutaneous devices that continuously monitor the heart rhythm and record events over a timeframe measured in years, allowing for the diagnosis of infrequent rhythm abnormalities that can be the cause of palpitations, syncope and stroke. To date, ICMs have primarily been used in the ...
Chan Ngai-Yin NY Consultant, Princess Margaret Hospital, Hong - - 2014
A 64-year-old woman underwent left atrial appendage occlusion with an Amplatzer Cardiac Plug device. Displacement of the device was detected on day 1 with transeosophageal echocardiographic checking. The device became dislodged and flitted in the left atrium after unsuccessful retrieval with a snare and 12F steerable transseptal sheath. A double ...
MaroszyƄska Iwona I 1Department of Intensive Care and Congenital Malformations of the Neonates and - - 2014
Congenital diaphragmatic hernia (CDH) is a malformation with a diverse clinical picture. Its severity can be assessed prenatally using the lung area to head circumference ratio (LHR). LHR lower than 1 as associated with high mortality is an indication for prenatal treatment involving occlusion of fetal trachea. Before such treatment ...
Lowalekar S K SK Cardiothoracic Surgery Division, Departments of Surgery, Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Boston, MA; VA Boston Healthcare System, Boston, - - 2014
Organ preservation at 4°C results in temporally irreversible injury to cellular structure and function. This study was designed to evaluate the possibility of storing hearts at ambient temperatures in novel organ preservation solution Somah to prevent damage and preserve optimum function by maintaining cellular energy over the temperature range of ...
Haeusler Karl Georg KG - - 2014
"Lone" atrial fibrillation (AF) is generally used to refer to patients with AF in the absence of structural heart disease. When the decision for oral anticoagulation is discussed, "lone" AF refers to patients who do not have established stroke risk factors. Imaging is often used to rule out structural heart ...
Badalzadeh Reza R Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, - - 2014
This study was designed to investigate the anti-arrhythmic effect of diosgenin preconditioning in myocardial reperfusion injury in rat, focusing on the involvement of the nitric oxide (NO) system and mitochondrial ATP-dependent potassium (mitoKATP) channels in this scenario. After isolation of the hearts of male Wister rats, the study was conducted ...
Gualandro Danielle M DM aDepartment of Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil bDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Basel, - - 2014
We aim to help clinicians to use and interpret high-sensitivity cardiac troponins (cTns) in different acute care settings. This guidance is timely and relevant as high-sensitivity cTns are currently replacing conventional cTn assays in most parts of the world. cTn I and T are structural proteins unique to the heart. ...
Moran D D Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland. Electronic address: - - 2014
We assessed adherence to European Society of Cardiology heart rate guidelines (i.e. heart rates less than 70bpm) in patients with chronic stable heart failure. We also investigated the percent of patients on target doses of rate controlling drugs. Multicenter study involving 549 patients from 12 heart failure centers in the ...
Jain Puneet Kumar PK Center of Excellence in Information and Communication Technology, Indian Institute of Technology Jodhpur, Rajasthan, India. Electronic address: - - 2014
To diagnose health status of the heart, heart monitoring systems use heart signals produced during each cardiac cycle. Many types of signals are acquired to analyze heart functionality and hence several heart monitoring systems such as phonocardiography, electrocardiography, photoplethysmography and seismocardiography are used in practice. Recently, focus on the at-home ...
Chu Chun-Yuan CY Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, - - 2014
The pre-ejection period-derived myocardial performance index measured from tissue Doppler echocardiography (PEPa-derived MPI) was reported to be associated with left ventricular systolic and diastolic function in atrial fibrillation (AF). However, its relationship with cardiovascular outcomes in AF has never been evaluated. This study sought to examine the ability of PEPa-derived ...
Winter Matthew D MD Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA - - 2014
'Valentine' heart shape is a common qualifier used in veterinary radiology to describe a cardiac silhouette with focal enlargement at the level of the base of the heart in feline patients. Anecdotally, this sign has been thought to be related to biatrial enlargement and also to hypertrophic cardiomyopathy (HCM). However, ...
Hartyánszky István I Semmelweis University Heart and Vascular Center, Budapest, Hungary - - 2014
Although circular ventricular resection techniques are the gold standard of left ventricular (LV) restoration, these techniques can lead to suboptimal results. Postoperative systolic resection can be inadequate, because it must be planned on a heart stopped in diastole. Low cardiac output due to insufficient LV volume results in a potentially ...
Omland T T Division of Medicine, Akershus University Hospital, Lørenskog, Norway; Center for Heart Failure Research and K.G. Jebsen Cardiac Research Centre, University of Oslo, Oslo, - - 2014
The signs and symptoms of heart failure are frequently unspecific and correlate poorly with objective indices of cardiac function. Objective assessment of cardiac function by echocardiography or other imaging modalities also correlate poorly with symptomatic status and functional capacity. Accordingly, there is a need for circulating biomarkers that can provide ...
Bernardo Bianca C BC Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia; julie.mcmullen@bakeridi.edu.au - - 2014
Expression of microRNA-652 (miR-652) increases in the diseased heart, decreases in a setting of cardioprotection, and is inversely correlated with heart function. The aim of this study was to assess the therapeutic potential of inhibiting miR-652 in a mouse model with established pathological hypertrophy and cardiac dysfunction due to pressure ...
Koerber Scott M SM Department of Internal Medicine, University of Missouri, Columbia, - - 2014
Electronic control devices (ECDs) are weapons used to incapacitate violent subjects. Subjects have died suddenly after ECD application, but because cardiac dysrhythmias have been inconsistently observed during ECD application in animals, the cause for death is uncertain. The objective was to identify the factors contributing to cardiac stimulation during ECD ...
Yang Shuang S Department of Pathology, Johns Hopkins University, Baltimore, - - 2014
Conduction abnormalities can lead to dyssynchronous contraction, which significantly worsens morbidity and mortality of heart failure. Cardiac resynchronization therapy (CRT) can reverse ventricular remodeling and improve cardiac function. Although the underlying molecular changes are unknown, the use of a canine model of dyssynchrony heart failure (DHF) and CRT has shown ...
Dionne P O PO Research Centre, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada; Department of Surgery, Montreal Heart Institute, University of Montreal, Montreal, Quebec, - - 2014
We describe the case of a 57-year-old woman who developed right heart failure after a second orthotopic bicaval cardiac transplant. Perioperative transesophageal echocardiogram showed a left atrial mass consisting of redundant tissue at the atrial suture line in the left atrium that did not have a significant hemodynamic effect under ...
Liu Bin B Cardiovascular Disease Center, First Hospital of Jilin University, Changchun 130021, Jilin, PR - - 2014
The electrocardiogram (ECG) is a biophysical electric signal generated by the heart muscle, and is one of the major measurements of how well a heart functions. Automatic ECG analysis algorithms usually extract the geometric or frequency-domain features of the ECG signals and have already significantly facilitated automatic ECG-based cardiac disease ...
Frustaci Andrea A aCardiovascular, Respiratory, Nefrologic, Anestesiologic and Geriatric Sciences Department, La Sapienza University bCellular and Molecular Cardiology Lab, IRCCS L. Spallanzani cInfectious Disease Department, IRCCS L. Spallanzani dRadiology Department, La Sapienza University, Rome, - - 2014
Right ventricle compromise affects survival of patients with HIV-associated pulmonary artery hypertension (PAH). Myocardial histology with viral assessment may clarify the mechanism of right ventricular deterioration and provide clues on PAH origin. Fifteen patients with HIV infection, PAH and right ventricular dysfunction underwent cardiac magnetic resonance, catheterization, coronary with ventricular ...
Röger Susanne S Medical Faculty Mannheim of the University of Heidelberg, 1st Department of Medicine, Mannheim, Germany; DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Germany. Electronic address: - - 2014
Cardiac contractility modulation (CCM) is an implantable device treatment for heart failure with reduced ejection fraction. CCM therapy improves patient functional status but its effect on intra-ventricular conduction remains unknown. 70 patients treated with CCM between 12/2002 and 5/2013 had 12-vector-ECG recordings made at baseline and final follow-up visits. QRS ...
Croteau Etienne E Sherbrooke Molecular Imaging Center of CRCHUS, Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Sherbrooke, QC, Canada. Electronic address: - - 2014
The ketone body acetoacetate could be used as an alternate nutrient for the heart, and it also has the potential to improve cardiac function in an ischemic-reperfusion model or reduce the mitochondrial production of oxidative stress involved in cardiotoxicity. In this study, [(11)C]-acetoacetate was investigated as an early marker of ...
Prescimone Tommaso T CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, - - 2014
Caspase (Casp)-1 has been indicated as a molecular target capable of preventing the progression of cardiovascular diseases, including heart failure (HF), due to its central role in promoting inflammation and cardiomyocyte loss. The aim of this study was to assess whether Left Ventricular Assist Device (LVAD) implantation modifies the inflammatory ...
Jankowska Ewa A EA Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland; Cardiology Department, Centre for Heart Diseases, Military Hospital, Wroclaw, Poland. Electronic address: - - 2014
We sought to determine and compare clinical profile and management of outpatients with heart failure with reduced ejection fraction (HFREF) treated by cardiologists and general practitioners (GPs) in Poland. All the 790 randomly selected cardiologists and GPs in the DATA-HELP registry, which included 5563 patients, filled out questionnaires about 10 ...
Haigney Mark M Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address: - - 2014
Breathing is a critical component of cardiopulmonary function, but few tools exist to evaluate respiration in ambulatory patients. Holter monitoring allows accurate diagnosis of a host of cardiac issues, and several investigators have demonstrated the ability to detect respiratory effort on the electrocardiogram. In this study we introduce a myogram ...
Wu Shujing - - 2014
Interactions between doxorubicin (DOX) and iron generate reactive oxygen species and contribute to DOX-induced heart failure. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for the treatment of a variety of diseases. Therefore, we investigated the preventive effects of hydrogen treatment on DOX-induced heart failure in rats. ...
Sezai Akira A Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, - - 2014
The vasopressin V2 receptor antagonist (Tolvaptan) is a new diuretic that selectively promotes the excretion of water. It has been reported to be effective for patients in cardiology, but there have been no reports of its use in the perioperative period after cardiac surgery. We report the usefulness of Tolvaptan ...
Loar Robert W RW Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota, - - 2014
Hypoplastic left heart syndrome (HLHS) is a form of congenital heart disease characterized by severe underdevelopment of the left heart, leading to inadequate systemic blood flow. Several different atrial septal morphologies are observed in HLHS, most commonly a secundum atrial septal defect, patent foramen ovale, intact septum, and leftward displacement ...
Hasin Tal T William J von Liebig Transplant Center, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota. Electronic address: - - 2014
Left ventricular assist devices (LVADs) acutely decrease left ventricular wall stress. Thus, early postoperative levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) should decrease. This study investigated postoperative changes in NT-proBNP levels, the parameters related to changes, and the possible association with complications by performing a retrospective analysis of changes in ...
Kim Chilsung C Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of - - 2014
Percutaneous extracorporeal life support (P-ECLS) is a useful modality for the management of refractory cardiac or pulmonary failure. However, venoarterial P-ECLS may result in a complication of left ventricular distension. In this case report, we discuss a patient with drug-induced dilated cardiomyopathy managed with venoarterial P-ECLS and a left atrial ...
Liu Sheng-da SD Department of Hyperbaric Oxygen, Beijing Aerospace General Hospital, Beijing, China. Electronic address: - - 2014
N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been used in the evaluation on heart function in many heart diseases. However, little is known in patients with acute carbon monoxide poisoning (ACOP). Left ventricular ejection fraction (LVEF) can be applied as a preliminary test method to measure the left ventricular function. In ...
Pozo Eduardo E The Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josee and Henry R. Kravis Center for Cardiovascular Health; Icahn School of Medicine, New York, United States; Servicio de Cardiología, Hospital Universitario de La Princesa, Madrid, - - 2014
Imaging techniques are essential in the clinical evaluation of patients with a myocardial infarction. They are of value for both initial assessment of the ischemic injury and for detection of the subgroup of patients at higher risk of developing cardiovascular events during follow-up. Echocardiography remains the technique of choice for ...
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