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Banitt E H - - 1986
The antiarrhythmic agent flecainide acetate was resolved by fractional crystallization of its diastereomeric alpha-bromocamphor-pi-sulfonate salts. Optical purity of the two enantiomers was shown to be greater than 99% by an NMR technique using the chiral shift reagent Eu(hfbc)3. Antiarrhythmic effects of flecainide and its enantiomers were assessed in two different ...
Marchetti G - - 1986
The activity of ibopamine (SB-7505), the 3,4-diisobutyryl ester of N-methyldopamine, on myocardial contractility and systemic and renal hemodynamics was investigated in the anesthetized dog with experimental infarction, instrumented with catheters and electromagnetic flowmeters. Ibopamine, given by the intraduodenal route at a dose of 24 mg/kg, was effective in improving the ...
Markiewicz W - - 1986
We compared the action of alfentanil on experimental myocardial infarction size with two widely used anesthetic drugs: fentanyl and halothane. Myocardial infarction size, measured by histological techniques, was identical for the three drugs investigated. Our results demonstrate that the action of alfentanil on factors governing myocardial oxygen supply and demand ...
Berti F - - 1986
Defibrotide is a polydeoxyribonucleotide of mammalian origin which possesses profibrinolytic effect and PGI2-releasing capacity. Because of these properties, defibrotide has antithrombotic effects which are demonstrated in various experimental models of venous and arterial thrombosis. The present study indicates that defibrotide clearly protects against myocardial damage in the rabbit 3 days ...
Dor X - - 1985
It seems difficult to escape the conclusion that conotruncal migration and torsions do occur: The amplitude, direction and timing of these movements can be accurately tracked and they can be experimentally arrested. The movements have a significant function: Associated with the partitionings, they regulate the outlet ventricular distribution at two ...
Opie L H - - 1985
Calcium antagonists are an important new modality in cardiovascular therapy. Tiapamil, a congener of verapamil, is undergoing clinical and laboratory evaluation. We have undertaken experimental studies on the anti-arrhythmic properties of tiapamil, and on the intravenous use of this agent in patients with acute myocardial infarction. Reasons are given for ...
Smith H J - - 1985
Experimental models of heart failure can be used to address specific questions not easily answered in patients, but no single model can reproduce exactly any of the clinical syndromes of heart failure since these are dominated by fatigue and breathlessness. Heart failure may be induced experimentally by pressure loading, volume ...
Löffelholz K - - 1985
This review has directed attention to the anatomical, biochemical, physiological, and pharmacological features of cardiac parasympathetic neuroeffector transmission. The relationships among these properties have permitted a synthesis of the operation of the parasympathetic nervous system at the subcellular, cellular, tissue, and organ level in the heart. However, the attempt to ...
Natelson B H - - 1985
This review focuses on the relations between neural structures and the heart in the pathogenesis of severe cardiac dysfunction (namely, cardiac arrhythmias, focal cardiac lesions, and the sudden death syndrome). After establishing the anatomic connections between the brain and the heart and then reviewing ways to assess the integrity of ...
Laorden M L - - 1985
The effect of the new beta-agonist drug tulobuterol, has been compared with isoproterenol in an experimental model of ectopic cardiac automaticity induced by local injury in the isolated right ventricle of the rat. Isoproterenol significantly increases ventricular automaticity even with the lowest concentrations tested (10(-9)M). Tulobuterol, at concentrations ranging from ...
David H - - 1985
Myocardial ischaemia in the dog lasting for three hours is followed by swellings of the mitochondria and dilatation of the sarcoplasmic reticulum. The volume density (Vv) of mitochondria in the peripheral ischaemia zone is 0.2890, that of sarcoplasmic reticulum is 0.0101. Prostacyclin was administered either i.v. or by triggering in ...
Laky D - - 1984
The present study concerns the morphological and biochemical lesional picture of the myocardium in cases of acute heart failure induced by various experimental models: ligature of the coronary artery, direct electric stimulation of the heart by catheterism, lethal hemorrhage, pneumothorax, beta-adrenergic shock. Worthy of note was the similitude of the ...
Kozlovskis P L - - 1984
Densitometric scanning of SDS-polyacrylamide gels was used to measure myosin heavy chain concentration in left ventricular specimens obtained from cat hearts 3 to 12 months after healing of small experimental myocardial infarctions. The study was designed to test the hypothesis that myosin concentration varies as a function of anatomic proximity ...
de Leiris J - - 1984
The aim of this paper is to consider the advantages of using isolated heart preparations in studies designed to investigate the effect of hypoxia or ischaemia on myocardial cells. After a brief description of the two most frequently used experimental models of perfused hearts, namely the Langendorff preparation and the ...
Cotoi S - - 1984
Experimental ventricular preexcitation type WPW was performed in five dogs, through an artificial bypass, an electric conductor, made of copper, with a diameter of 8 mm and 12 cm in length. Whenever the conductor was put in contact with both the atrial and the ventricular wall, a WPW electrocardiogram pattern ...
García-Peláez I - - 1984
The role of the superior atrioventricular cushion in the normal development of the left ventricular infundibulum was experimentally studied in the chick embryo. 178 embryos at stages 19-24 of Hamburger and Hamilton were selectively labeled using gelatin-india ink; afterward embryos were reincubated until the mature heart stage, in which the ...
Khaw B A - - 1984
Monoclonal antibody R11D10 to human cardiac myosin, which also cross-reacted with canine cardiac myosin, was used to demonstrate in vivo localization and visualization by gamma scintigraphy of experimental myocardial infarction. R11D10 Fab with a Ka of 5 X 10(8) M-1 was labeled with technetium-99m (99mTc) by the dithionite reduction method ...
Hood W B WB - - 1983
Much of our knowledge about the effects of coronary occlusion and reperfusion is derived from studies in experimental animals. The recent discovery that coronary thrombosis is usually present in clinical myocardial infarction and that thrombolysis represents an approach to therapy presents opportunities for further experimental work. Animal models are particularly ...
Jacob H S - - 1983
C5A is capable of causing granulocyte/granulocyte interactions that lead to clumping, vasoocclusion, and the extension of infarctive damage in patients with coronary artery disease. Employing a new rheologic procedure, laser transillumination of thin vascular beds, one directly observes in vivo granulocyte aggregation in the mesentery of the rat. Nonsteroidal antiinflammatory ...
Hofmeyr G J - - 1983
The sequence of fetal heart rate (FHR) changes recorded in a case of acute fetal haemorrhage is reported. Initial bradycardia progressed through an undulatory phase to tachycardia. Analysis of these patterns in the context of experimental data on intrinsic heart rate control suggests that the FHR was limited by availability ...
Thomas A C - - 1983
The practical value of measuring the ratio of potassium ion (K+) to sodium ion (Na+) in myocardium as an indicator of early inapparent infarction in sudden cardiac death was assessed using a series of 29 human hearts from selected coroner's autopsies together with experimental material from dogs, including infarcts of ...
Chien K R - - 1983
Ligation of the circumflex artery of anaesthetised, open-chest rabbits caused a progressive increase in nonsedimentable cathepsin D activity in severely ischaemic myocardium and an anatomical redistribution of the enzyme from lysosomes into the cytosol, along with progressive ultrastructural signs of cellular damage and necrosis. Chlorpromazine pretreatment (15 mg X kg-1 ...
Al-Rufaie H K - - 1983
A retrospective study has been carried out on the necropsy material from 30 patients who have died after a clinically diagnosed myocardial infarction. This study has been undertaken to compare the reliability of the fluorescence of infarcted myocardium when stained by haematoxylin and eosin and an adjacent section stained by ...
Zatz L M - - 1983
The planimetric measurement of the area of the ventricles on a computed tomographic section is a convenient and useful method of assessing ventricular size when more sophisticated techniques are not available. It is commonly reported as a planimetric ventricular-brain ratio or VBR. Ventricular size is related to cranial size in ...
O'Connor W N - - 1983
Experimental myocardial infarction of the posterolateral left ventricular wall in 2 dog hearts, the result of 1 h of occlusion of the left circumflex coronary artery followed by 4 days of reperfusion, was studied post mortem by serial histological sectioning. Microscopic examination in a transverse plane showed a zone of ...
Hearse D J - - 1983
At the present time our experimental findings plus the weight of other experimental evidence suggest that there is unlikely to be a quantitatively significant border zone in the lateral plane. The transition from normal to ischemic tissue is likely to be accomplished over a distance of 1.0 mm or less ...
Meerson F Z - - 1982
A working hypothesis on pathogenesis of ischemic heart damage has been proposed. According to this hypothesis, a crucial role in conversion of reversible damage into irreversible damage is played by cardiomyocyte membrane destruction caused by the so-called "lipid triad". The latter comprises activation of lipid peroxidation, activation of phospholipases, and ...
Uherík A - - 1982
The hypothesis on the relationship between biofeedback and the psychophysiological regulatory properties of Ss was tested experimentally. The Ss were 17 adult males after myocardial infarction, 13 patients with bronchial asthma and 18 healthy adults. Biofeedback was followed through a continuous bioelectrical skin reactivity (BSR) recording as an indicator of ...
Faarup P - - 1982
Infarcts of the rabbit kidney were experimentally induced in 22 animals by selective left renal arteriography using the genuine foreign bodies present in the contrast media and catheters as damaging agents. Three days later the infarcts were macroscopically located and measured at laparotomy. Three weeks later the infarcts were macroscopically ...
Tanaka T - - 1982
The influence of differential washout on the redistribution phenomenon of thallium 201 chloride deposited in ischemic myocardium was investigated. Two groups of dogs had serial scintigraphic images and tissue counting performed. The first group had ischemia produced prior to the injection of the thallium and, following the control image after ...
Milei J - - 1982
The normal electrocardiographic (ECG) pattern was determined for Cebus monkeys and compared with those obtained in animals subjected to experimental heart damage. ECG patterns were related to the anatomopathological findings in both normal and treated animals. The anatomic study revealed a vertical heart in which both ventricles constituted the frontal ...
Antalóczy Z - - 1982
Under experimental conditions, potassium canrenoate causes a significant increase in [3H]norepinephrine (NE) uptake by the heart, although the NE content remains unchanged. The increased NE uptake and unchanged NE content indicate an augmented NE turnover caused by the drug. In saluretic-pretreated animals, the intracellular hypopotassemia can be restored by Aldactone. ...
Samuel J L - - 1981
Histoenzymological techniques were used to examine ATPase activity in rat heart muscle fibres after experimental infarction. 25 hours after coronary ligation, ATPase activity in all ventricular section fibres was high, homogeneous at pH 9.4, sections. 48 hours after ligation, necrotic ventricular fibres appeared, leaving only a thin layer of fibres ...
Hugod C - - 1981
Rabbits were continuously exposed to 200 ppm carbon monoxide. Using the same criteria as applied by earlier investigators for morphological myocardial damage, no histotoxic effect on myocardial morphology could be demonstrated when electron-microscopic investigations were performed blindly. Similarly, exposure to 0.5 ppm hydrogen cyanide, 0.5 ppm hydrogen cyanide + 200 ...
Polson H - - 1981
Results of our experimental studies have demonstrated that, during the evolution of mesenteric infarction, lysosomal membrane instability occurs with the release of beta-N acetylhexosaminidase into the portal and systemic circulation. Preliminary clinical results suggest an elevation of the Hex B fraction in mesenteric infarction. Measurements of total and various fractions ...
Unger T - - 1981
Listeners who had demonstrated right-ear dichotic listening preference in the first of four listening sessions were randomly assigned to an experimental and control group. Both groups participated in three more dichotic listening sessions. For sessions 2 and 3, left-ear responses were reinforced for the experimental group listeners. There was a ...
Katzeff I E - - 1981
This paper experimentally evaluates the "imaginary cardiac vector" hypothesis, that the cardiac vector is not a real vector. We have previously shown on theoretical grounds that the basis of the cardiac vector is invalid in that Einthoven used scalar, not vector, procedures. Attempts by subsequent workers to compensate for the ...
Raku┼Łan K - - 1981
Quantitative evaluation of the myocardial left ventricular capillarity was performed in three groups of guinea pigs: a) animals native to high altitude collected in Andean mountains, b) animals born at sea level and subjected to a stimulated high altitude postnatally, c) animals born and kept at sea level. The number ...
Carle B N - - 1981
A method is described for demonstrating myocardial necrosis by changes in the autofluorescence of routine hematoxylin and eosin or hematoxylin and eosin-phloxine stained sections using a standard microscope with an epifluorescence attachment. Regions of necrosis fluoresce with a brilliant yellow color clearly distinguishable from the dull olive-green to red-brown fluorescence ...
Seybold V - - 1981
The indirect immunofluorescence technique was used to examine the pharmacology associated with reserpine-induced alterations in vasopressin and neurophysin (VP/NP) immunoreactivity in the external layer of the median eminence in the rat. Twenty-four hours after injection of reserpine, a selective, marked depletion of VP/NP immunoreactivity from the external layer is apparent. ...
Parry G J - - 1981
Despite the clinical importance of ischemia in the pathogenesis of many human neuropathies, little is known about the effect of circulatory compromise on the structure of peripheral nerves. This results in part from the lack of an entirely satisfactory model in which to study ischemic neuropathy. We therefore injected arachidonic ...
Leprán I - - 1981
Four non-steroid anti-inflammatory drugs, sulfinpyrazone, acetylsalicylic acid, sodium salicylate and indomethacin were tested in the acute phase of experimental myocardial infarction in conscious rats. A single oral dose was administered, then 1 h later the occlusion of the left anterior descending coronary artery was made by using a previously implanted ...
Vizda J - - 1981
A survey is presented of research results of pyrophosphate myocardial scanning in 130 dogs and 150 patients with various myocardial lesions. The results of experiments in animals were immediately applied in clinical practice. The results showed that acute transmural myocardial lesions yielded practically in all instances positive scintigraphic findings. The ...
Lau V K - - 1981
Cardiac trauma can be experimentally produced by blunt impulsive impact over the cardiac apex in the anesthetized canine. A gradation of myocardial injury, including transient arrhythmia, contusion, and lethal ventricular fibrillation, can be produced by varying the power of the charge in a modified captive bolt pistol. Ballistics experiments were ...
Willerson J T - - 1980
Alterations in cell and subcellular membrane integrity occur during evolving ischemic myocardial injury. We tested the hypothesis that an antibody against human liver mitochondria [anti-mitochondrial antibody developing in a patient with primary biliary cirrhosis] could identify altered cell membrane integrity in experimental canine myocardial infarcts. The proximal left anterior descending ...
Laky D - - 1980
The dynamics of morphologic and biochemical lesions of the myocardial fiber during the first ten days after an experimental myocardial infarction showed an unequal evolution of the lesional picture in the ischaemic area, the intervention of lysosomal hydrolases and the reactions of inflammatory fibrocollagen substitution. Morphologic aspects in the areas ...
Abe T - - 1980
The most important and effective factor for myocardial protection during cardiac operation is to keep the myocardium at as low a temperature as possible. The ideal temperature is around 15 degrees C. A thumbtack type of needle thermistor has been developed and used clinically and experimentally during myocardial protection. This ...
Czarnecki C M - - 1980
Furazolidone (FZ) at 700 ppm was added to feed mixtures fed turkey poults two weeks posthatching to induce experimental cardiomyopathy. Poults in the control pen received the same ration but without FZ. From ECG data obtained at weekly intervals, poults were selected for sacrifice at 3, 4, and 5 weeks ...
Adams S B - - 1980
Cytologic examination of serial peritoneal fluid samples of nine experimental ponies was performed during a 72 hour period following laparotomy. Six of the ponies had jejunal infarction induced by occlusion of the corresponding vasculature. Cytologic examination was also performed on the peritoneal fluid of a series of horses with naturally ...
Reimer K A - - 1980
Because patient prognosis is related in part to infarct size, therapies that could limit infarct size should be beneficial. The development of such therapies has been hampered by the lack of proven techniques to measure infarct size or to assess the effect of therapy in living patients. In addition, the ...
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