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Simon Roger P - - 2010
Ictal events include those of the autonomic nervous system. This sympathetic stimulation may persist into the postictal period, affecting cardiopulmonary function. Such postictal effects include potentially fatal alterations in cardiac rhythm and ventilatory function, management challenges such as pulmonary edema, and diagnostically confusing laboratory abnormalities such as fever and cerebrospinal ...
Jansen K K University Hospitals Leuven, Herestraat 49, 3000 Leuven, - - 2010
Epilepsy and seizures can have a dramatic effect on the autonomic nervous system by involvement of the central autonomic control centers. The peri-ictal changes can lead to short-term alteration of cardiac functions in patients with seizures, and are partially hemispheric specific. Changes in heart rhythm, conduction and even subtle signs ...
Ji Sang Yong - - 2010
Cardiac autonomic function plays a crucial role in health and disease, with abnormalities both reflecting the severity of the disease and contributing specifically to clinical deterioration and poor prognosis. Radiotracer analogs of the sympathetic mediator norepinephrine have been investigated extensively, and are at the brink of potential widespread clinical use. ...
Sánchez-Lázaro Ignacio J - - 2011
An alteration of the autonomic nervous system has been described in heart failure (HF). The aim of this study was to assess, compare and relate the impairment of both arms of the autonomic nervous systems, the sympathetic and parasympathetic (SNS and PNS) in a same group of patients. We analyzed ...
Bhattacharyya Mimi R MR Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, - - 2011
Emotion in daily life may be associated with transient myocardial ischemia, ventricular tachycardia and impaired autonomic function in cardiac patients, but the precise temporal sequence is unclear. Eighty-eight patients with suspected coronary artery disease underwent 24-h electrocardiographic monitoring, and affect was measured with the Day Reconstruction Method. Thirteen patients (15%) ...
Chan Christopher T - - 2010
Cardiovascular events are common in patients with ESRD. Whether sympathetic overactivity or vagal withdrawal contribute to cardiovascular events is unclear. We determined the general prevalence and clinical correlates of heart rate variability in patients on hemodialysis. We collected baseline information on demographics, clinical conditions, laboratory values, medications, physical performance, left ...
Sredniawa Beata - - 2010
BACKGROUND: Previous studies have shown conflicting results about the value of heart rate turbulence (HRT) for risk stratification of patients (pts) with chronic heart failure (CHF). We prospectively evaluated the relation between HRT and progression toward end-stage heart failure or all-cause mortality in patients with CHF. METHODS: HRT was assessed ...
Goldstein David S DS Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892-1620, USA. - - 2010
Important recent publications in the area of neuroscience and heart-brain medicine center largely around three topics: (1) mechanisms of cardiac sympathetic denervation in Parkinson disease, (2) cytoplasmic monoamine metabolites as autotoxins, and (3) the validity of power spectral analysis of heart rate variability to indicate cardiac sympathetic tone. Findings by ...
Volders Paul G A - - 2010
It has long been recognized that increased sympathetic nerve activity during physiologic stress (exercise, swimming, emotion, arousal, loud noise, etc.) has profound influences on the electrical and contractile functions of the heart. In the severely predisposed heart, these stressors may lead to ventricular tachyarrhythmias and sudden death. Still little is ...
Patel Hitesh - - 2011
Autonomic dysfunction (AD) is associated with morbidity and mortality in patients with systolic heart failure (SHF). The extent of AD when LV ejection fraction is preserved (HF-NEF), is unclear. Our objectives were: 1) quantitative assessment of autonomic function in SHF and HF-NEF; and 2) exploration of relationships among AD, symptoms ...
Buob Axel - - 2010
Autonomic cardiovascular dysfunction is common in Parkinson's disease (PD). Imaging studies suggest loss of cardiac sympathetic nerves even in the absence of clinical signs of autonomic dysfunction. Aim of the study was to investigate the functional significance of autonomic cardiovascular denervation at early stages of PD. Seven PD patients (Hoehn ...
Fu Liang-Wu - - 2010
Myocardial ischaemia activates cardiac sympathetic afferents leading to chest pain and reflex cardiovascular responses. Previous studies have shown that a brief period of myocardial ischaemia increases endothelin in cardiac venous plasma draining ischaemic myocardium and that exogenous endothelin excites cutaneous group III and IV sensory nerve fibres. The present study ...
Scholte Arthur J H A - - 2010
The purpose of this study was to evaluate the prevalence of cardiac autonomic neuropathy (CAN) in a cohort of patients with type 2 diabetes, truly asymptomatic for coronary artery disease (CAD), using heart rate variability (HRV) and (123)I-metaiodobenzylguanidine ((123)I-mIBG) myocardial scintigraphy. The study group comprised 88 patients with type 2 ...
Pieper Suzanne - - 2010
OBJECTIVES: To test the hypothesize that increased heart rate (HR) and decreased heart rate variability (HRV) are not only due to concurrent stressful events and worries but also to stressors and worries occurring in the preceding hours or stressors anticipated to occur in the next hour. Worry was expected to ...
Kimura Kensuke - - 2010
In severe congestive heart failure (CHF), sympathetic overactivity correlates with the exacerbation of cardiac performance. To test the hypothesis that the cardiac sympathetic nerve density dramatically changes with the acceleration of circulating norepinephrine (NE) concentration, we investigated the temporal association of nerve growth factor (NGF) expression in the heart and ...
Dikecligil Gülce N - - 2010
Heart rate variability (HRV) measures homeostatic regulation of the autonomic nervous system in response to perturbation and has been previously shown to quantify risk for cardiac events. Despite known interactions among stress vulnerability, psychiatric illness, and cardiac health, however, this is the first study to our knowledge to compare directly ...
Magrans R - - 2010
We assess autonomic nervous system response during prolonged percutaneous transluminal coronary angioplasty (PTCA) using heart rate variability analysis with multifractal indices. These indices are used to evaluate the effects of the PTCA procedures at different arteries and locations. A total of 55 patients from the Staff3 database, with no prior ...
Saburkina Inga - - 2010
Sheep are routinely used in experimental cardiac electrophysiology and surgery. The purpose of this study was to (1) ascertain the topography and architecture of the ovine epicardial neural plexus (ENP), (2) determine the relationships of ENP with vagal and sympathetic cardiac nerves and ganglia, and (3) evaluate gross anatomic differences ...
Lujan Heidi L - - 2010
The Cardiac Arrhythmia Suppression Trial demonstrated that antiarrhythmic drugs not only fail to prevent sudden cardiac death, but actually increase overall mortality. These findings have been confirmed in additional trials. The "proarrhythmic" effects of most currently available antiarrhythmic drugs makes it essential that we investigate novel strategies for the prevention ...
Goya-Esteban Rebeca - - 2010
Heart rate variability (HRV) markers have been widely used to characterize the autonomous regulation state of the heart from 24-h Holter monitoring, but long-term evolution of HRV indexes is mostly unknown. A dataset of 7-day Holter recordings of 22 patients with congestive heart failure was studied. A rhythmometric procedure was ...
Jones David E J DE Institute of Cellular Medicine, Newcastle Univ., - - 2010
Cardiovascular system dysregulation in the form of autonomic dysfunction is common at all stages of the disease process in the autoimmune liver disease primary biliary cirrhosis (PBC) and associates with the symptom of fatigue. The mechanisms underpinning autonomic dysfunction in PBC are, however, at present unclear. In this study we ...
Lara Aline - - 2010
Overwhelming evidence supports the importance of the sympathetic nervous system in heart failure. In contrast, much less is known about the role of failing cholinergic neurotransmission in cardiac disease. By using a unique genetically modified mouse line with reduced expression of the vesicular acetylcholine transporter (VAChT) and consequently decreased release ...
Fazio Giovanni - - 2010
BACKGROUND: It is well-known that a reduction of the cardiac frequency variability, measurable with the Heart Rate Variability (HRV) system, is an indirect expression of the sympathetic-autonomic tone. Another index, Heart Rate Turbulence (HRT), has been recently suggested as a possible unit of measurement for the sympathetic-autonomic tone: this system ...
Sevcencu Cristian - - 2010
Studies with heart rate variability have revealed interictal autonomic alterations in patients with epilepsy. In addition, epilepsy is frequently associated with ictal tachycardia or bradycardia, which sometimes precedes the onset of seizures. Ictal tachycardia is sometimes associated with electrocardiography (ECG) morphologic changes and ictal bradycardia often progresses to asystole. Such ...
Smith Michael L - - 2010
BACKGROUND: Sudden cardiac death is usually caused by ventricular arrhythmias and in many cases, is preceded by frequent ventricular ectopy. It is known that ectopic beats cause transient increases in sympathetic nerve activity (SNA). OBJECTIVE: Because high SNA is known to be arrhythmogenic, we hypothesized that high rates of ectopy ...
Kanazawa Hideaki - - 2010
Although several cytokines and neurotrophic factors induce sympathetic neurons to transdifferentiate into cholinergic neurons in vitro, the physiological and pathophysiological roles of this remain unknown. During congestive heart failure (CHF), sympathetic neural tone is upregulated, but there is a paradoxical reduction in norepinephrine synthesis and reuptake in the cardiac sympathetic ...
Levick Scott P SP Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, - - 2010
Chronic activation of the sympathetic nervous system is a key component of cardiac hypertrophy and fibrosis. However, previous studies have provided evidence that also implicate inflammatory cells, including mast cells (MCs), in the development of cardiac fibrosis. The current study investigated the potential interaction of cardiac MCs with the sympathetic ...
Hill Labarron K - - 2010
Conceptualizations of parasympathetic and sympathetic activity of the autonomic nervous system as representing a bi-dimensional autonomic space have driven recent discussions surrounding the degree of respective and interactive influence of each branch on visceral organs (e.g. heart). An important consideration of autonomic influences on cardiac function is the presence of ...
Drakos Stavros G - - 2010
OBJECTIVES: The purpose of this study was to analyze the effects of left ventricular assist devices (LVADs) on myocardial sympathetic innervation of the failing heart. BACKGROUND: Ventricular unloading by LVADs seems to cause reverse remodeling of the failing heart, but little is known about the sympathetic nerve activity during long-term ...
Christensen J H - - 2010
Studies suggest that marine n-3 polyunsaturated fatty acids (PUFA) offer some protection against sudden cardiac death (SCD). The autonomic nervous system is involved in the pathogenesis of SCD and due to the fact that n-3 PUFA is abundant in the brain and other nervous tissue it is likely that n-3 ...
Turker Yasin - - 2010
BACKGROUND: Coronary artery ectasia (CAE) is characterized by an abnormal dilatation of the coronary arteries, which is a variant of coronary artery disease (CAD). Increased sympathetic activity or decreased vagal modulation of cardiac function assessed by heart rate variability (HRV) analysis has been associated with an increased risk of coronary ...
I?ler Y - - 2010
In this study, the effects of heart rate (HR) normalization in the analysis of the heart rate variability (HRV) were investigated to distinguish 29 patients with congestive heart failure from 54 healthy subjects in the control group. In the analysis performed, the best accuracy performances of optimal combination of standard ...
Schneider Alexandra - - 2010
Exposure to ambient particles has been shown to be responsible for cardiovascular effects, especially in elderly with cardiovascular disease. The study assessed the association between deceleration capacity (DC) as well as heart rate variability (HRV) and ambient particulate matter (PM) in patients with coronary artery disease (CAD). A prospective study ...
Leonarduzzi Roberto Fabio RF Lab. Signals and Nonlinear Dynamics, Faculty of Engineering, Universidad Nacional de Entre Ríos, Argentina. - - 2010
Heart rate variability is a non invasive and indirect measure of the autonomic control of the heart. Therefore, alterations to this control system caused by myocardial ischaemia are reflected in changes in the complex and irregular fluctuations of this signal. Multifractal analysis is a well suited tool for the analysis ...
Goldie Jessica J Faculty of Health Sciences, University of Ontario Institute of Technology, 2000 Simcoe St. N., Oshawa, L1H 7K4 Canada. - - 2010
Introduction. Electrocardiography (ECG) can be used to collect heart rate data which in turn can be used to measure heart rate variability (HRV). The sympathetic and parasympathetic nervous systems have the ability to affect this variability, which can ultimately affect arousal levels.
D'Addio Gianni G S. Maugeri Foundation, Bioengeneering Dpt. of Rehabilitation Institute of Telese, via Bagni Vecchi 82037 Telese Terme, (BN) Italy. - - 2010
Cardiovascular oscillations following spontaneous ventricular premature complexes (VPC) are characterized by a short-term heart rate fluctuation known as heart rate turbulence (HRT) described by the so-called turbulence onset (TO) and slope (TS). Despite a recent written consensus on the standard of HRT measurement, reproducibility data are lacking. Aim of the ...
Di Rienzo Marco M Dept. of Biomedical Technology, "Santa Maria Nascente" Research Hospital, Fondazione Don Carlo Gnocchi, 20148 Milan, Italy. - - 2010
The Push-Pull Effect (PPE) is a physiological phenomenon defined as a reduction of +Gz tolerance induced by a previous exposure to a -Gz acceleration, that may lead to loss of consciousness. Aim of this study was to evaluate, for the first time, the cardiac rhythm changes associated with PPE during ...
Akutsu Yasushi - - 2010
We evaluate the systemic right ventricle (SRV) failure of congenitally corrected transposition of the great arteries using the scintigraphic studies in a case with 32-year-old male who improved the heart failure by the use of beta-adrenergic blockers. The myocardial perfusion sympathetic nervous system activity mismatch with preserved coronary flow and ...
Mueller E M - - 2010
Cortical efferences to the heart are important for cardiovascular health, psychopathology, emotion regulation and other dimensions of human functioning. Although researchers have already begun to outline the underlying neuroanatomy, the timing of neurovisceral communication in humans is difficult to study non-invasively. A possible coupling between the brain and the heart ...
Khandoker Ahsan H - - 2010
Early sub-clinical assessment of severity of cardiac autonomic neuropathy (CAN) and intervention are of prime importance for risk stratification and early treatment in preventing sudden death due to silent myocardial infarction. The Ewing battery is currently the diagnostic tool of choice but is unable to detect sub-clinical disease and requires ...
Esler Murray - - 2010
Sympathetic nervous system responses typically are regionally differentiated, with activation in one outflow sometimes accompanying no change or sympathetic inhibition in another. Regional sympathetic activity is best studied in humans by recording from postganglionic sympathetic efferents (multiunit or single fiber recording) and by isotope dilution-derived measurement of organ-specific norepinephrine release ...
Huang Chien-Hua - - 2010
Epidemiological studies show an association between particulate matter exposure and acute heart failure. However, underlying mechanisms remain unclear. In this study, we investigated acute cardiac hemodynamic effects and related mechanisms after 1 day exposure to diesel exhaust particles (DEPs). Male Sprague-Dawley rats were randomized and instilled with 250 microg (low ...
Fu Liang-Wu - - 2010
Myocardial ischemia is a complex process leading to the simultaneous release of a number of mediators, including thromboxane A(2) (TxA(2)) and bradykinin (BK), that activate cardiac spinal afferents. The present study tested the hypothesis that TxA(2) and BK reciprocally interact to excite ischemically sensitive cardiac afferents. Nerve activity of single ...
Soliman Elsayed Z - - 2010
AIMS: High resting heart rate (HR) has been associated with sudden cardiac death (SCD). This association is not fully explained by the reported association between HR with coronary heart disease (CHD) or left ventricular systolic dysfunction, the major pathological substrates for SCD. Ventricular arrhythmia is the most common antecedent event ...
Valencia Jose F - - 2009
This work has proposed a methodology based on the concept of entropy rates to study the complexity of the short-term heart-rate variability (HRV) for improving risk stratification to predict sudden cardiac death (SCD) of patients with established ischemic-dilated cardiomyopathy (IDC). The short-term HRV was analyzed during daytime and nighttime by ...
Parrish Diana C DC Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, - - 2010
Myocardial infarction causes a heterogeneity of noradrenergic transmission that contributes to the development of ventricular arrhythmias and sudden cardiac death. Ischaemia-induced alterations in sympathetic transmission include regional variations in cardiac noradrenaline (NA) and in tyrosine hydroxylase, the rate-limiting enzyme in NA synthesis. Inflammatory cytokines that act through gp130 are elevated ...
Maestri Roberto - - 2010
Despite a well-established prognostic value in cardiac patients, HRV (heart rate variability) indexes have been used little in the clinical setting. Poor reliability of the measurements might be a possible explanation for this. In the present study, we assessed the reliability of short-term HRV indexes in post-MI (myocardial infarction) patients. ...
Karmakar C K - - 2009
The asymmetry in heart rate variability is a visibly obvious phenomenon in the Poincaré plot of normal sinus rhythm. It shows the unevenness in the distribution of points above and below the line of identity, which indicates instantaneous changes in the beat to beat heart rate. The major limitation of ...
Ghebremedhin Estifanos - - 2009
Clinical and autopsy studies have consistently reported cardiac sympathetic dysfunction in the left ventricular wall in patients with Parkinson's disease (PD). Whether the nerve fibers of the cardiac conduction system or the atrial walls are equally affected in this disease process has not yet been well documented. Therefore, the aim ...
Chen Hung Yi - - 2009
BACKGROUND: Heart rate turbulence (HRT) has recently been introduced as a noninvasive tool for studying autonomic dysfunction. It presented short time fluctuation of sinus cycle length following single ventricular premature contraction (VPC). However, HRT parameters may be influenced by different factors. This study aimed to evaluate the possible influence of ...
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