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Javard Romain R Companion Animal Research Group, Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC J2S 7C6, - - 2014
Objective-To evaluate the usefulness of Doppler-derived peak flow velocity through the left ventricular outflow tract (LVOT Vmax) and effective orifice area indexed to body surface area (EOAi) in puppies to predict development of subaortic stenosis (SAS) in the same dogs as adults. Design-Prospective, longitudinal, observational study. Animals-38 Golden Retrievers. Procedures-Cardiac ...
Kasa Jaya Kiran JK Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, Uttar Pradesh, - - 2014
The present study was undertaken to evaluate the effect of alcoholic extract of Dalbergia sissoo leaf extract (DSE) on isoproterenol (ISP)-induced myocardial injury in rats. Evaluation of three doses (30, 100 and 300 mg/kg of body weight) of DSE was done in ISP-treated rats. ISP was used at 85 mg/kg body weight by ...
Aydinok Yesim Y Ege University Hospital, Izmir, - - 2014
The randomized comparison of deferasirox to deferoxamine for myocardial iron removal in patients with transfusion-dependent anemias (CORDELIA) gave the opportunity to assess relative prevalence and body distribution of iron overload in screened patients. Patients aged ≥10 years with transfusion-dependent anemias from 11 countries were screened. Data were summarized descriptively, overall ...
Rio Rodrigo Del RD Laboratory of Cardiorespiratory Control, Center of Biomedical Research, Universidad Autónoma de Chile, Santiago, Chile - - 2014
Chronic heart failure (CHF) is a leading medical problem worldwide. Common hallmarks of CHF include autonomic imbalance and breathing disorders, both of which are closely related to the progression of the disease and strongly predict mortality in CHF patients. The role played by the carotid body (CB) chemoreceptors on the ...
Zemrak Filip F Centre for Advanced Cardiovascular Imaging, Queen Mary University of London, The London Chest Hospital, London, United - - 2014
Left ventricular (LV) trabeculation is highly variable among individuals and is increased in some diseases (e.g., congenital heart disease or cardiomyopathies), but its significance in population-representative individuals is unknown. The goal of this study was to determine if excessive LV trabeculation in population-representative individuals is associated with preceding changes in cardiac ...
Lai Shenghan S From the Department of Pathology (SL, JL, HZ, SC), Department of Medicine (SL, GG), Department of Radiology (SL, C-YL, SLZ, HL), and Department of Psychiatry (GT), Johns Hopkins School of Medicine, Baltimore, MD; Department of Epidemiology and Biostatistics (HZ), Tianjin Medical University, Tianjin, China; and Radiology and Imaging Sciences (DAB, C-YL), NIH Clinical Center, Bethesda, - - 2014
Cardiac steatosis is a manifestation of ectopic fat deposition and is associated with obesity. The impact of chronic cocaine use on obesity measures and on the relationship between obesity measures and cardiac steatosis is not well-characterized. The objectives of this study were to compare obesity measures in chronic cocaine users ...
Altay Servet - - 2014
The definition of glomerular hyperfiltration has not been agreed upon and the pathophysiological mechanisms have not been well explored. Low serum creatinine concentrations may be associated with increased risk of coronary heart disease (CHD) or cardiopulmonary events the impact of which needs further study. Consecutive applicants to a cardiovascular hospital ...
Rafael Beatrix B Psychiatric Clinic, University of Szeged, Szeged, Hungary; Special Hospital of Chest Illnesses, Deszk, - - 2014
To examine psychological risk factors and somatic factors in patients after myocardial infarction. To study the relationship between somatic and psychological factors, their influence on subjective quality of life (well-being) and also to examine possible gender differences. There has been a growing body of evidence that psychosocial factors are risk ...
Shimada Mai M Department of Emergency Medicine, Maimonides Medical Center, Brooklyn, New - - 2014
Patients suffering from heatstroke often present with electrocardiograph abnormalities, but persistent ventricular tachycardia has not been reported previously. This report is intended to demonstrate that rapid and effective cooling is critical to survival in patients experiencing heatstroke with ventricular tachycardia. We cared for a healthy 38-year-old man with environmentally induced ...
Alpert Martin A MA Division of Cardiovascular Medicine and Department of Surgery, University of Missouri School of Medicine, Columbia, - - 2014
Obesity has been reported to be associated with delayed ventricular repolarization. The purpose of this study was to assess ventricular repolarization in normotensive severely obese subjects with and without heart failure (HF) and to assess the effect of weight loss on ventricular repolarization in such patients. Twenty-eight patients with and ...
Kylmälä Minna M MM Division of Cardiology, Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland; BioMag Laboratory, Hospital District of Helsinki and Uusimaa HUSLAB, Helsinki University Central Hospital, Helsinki, - - 2014
Assessment of myocardial infarct (MI) size is important for therapeutic and prognostic reasons. We used body surface potential mapping (BSPM) to evaluate whether single-lead electrocardiographic variables can assess MI size. We performed BSPM with 120 leads covering the front and back chest (plus limb leads) on 57 patients at different ...
Fontes-Carvalho Ricardo R Cardiology Department, Gaia Hospital Center, Gaia, Portugal; Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal. Electronic address: - - 2014
Obesity has been associated with subclinical left ventricular (LV) diastolic dysfunction and increased risk of heart failure. Few data are available on the relative contribution of adiposity distribution and changes in myocardial structure and function. We evaluated the influence of visceral versus subcutaneous abdominal adipose tissue and epicardial fat on ...
Haroon Javeria J Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Molecular Biology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Morphology, Federal University of Minas Gerais (UFMG), 31270-010 Belo Horizonte, Minas Gerais, Brazil; Department of Physiology and Biophysics, Federal University of Minas Gerais (UFMG), 31270-010 Belo Horizonte, Minas Gerais, - - 2014
This study examined the sex differences for physical, morphological, histological, mRNA, and protein expression levels changes for interleukins and natriuretic peptides in left ventricle (LV) of two groups of adult FVB/N mice; males (WM) and females (WF). LV morphological, histological, reverse transcription and quantitative real-time PCR (RT-PCR), and immunohistochemical (IHC) ...
Iliodromitis Efstathios K EK Second Department of Cardiology, Medical School, Attikon University Hospital, Athens, - - 2014
Conditioning refers to endogenous mechanisms rendering the myocardium more tolerant against reperfusion injury. Application of brief ischemia-reperfusion cycles prior to the index ischemia has a beneficial effect and limits the infarct size. This is called preconditioning and is mainly mediated by activation of adenosine, bradykinin, opioid and other receptors, with ...
Racca V V S. Maria Nascente Institute IRCCS, Don Carlo Gnocchi Foundation, Milan,Italy Rehabilitative Cardiology - - 2014
Heart surgery is a frequent reason for admission to in--patient cardiac rehabilitation programmes. ICF approach has never been used to evaluate cardiac patients after major heart surgery. The aim was to evaluate and measure functionality in cardiac patients who have undergone heart surgery, using for the first time the ICF--based ...
Conceicão Maria Eduarda B A M - - 2014
The effects of body biometrics on cardiac measurements and description of cardiac anatomy were performed in red-tailed boas (Boa constrictor constrictor) (n = 29) using real-time B-mode ultrasonography. Statistical comparison of measured cardiac metrics according to sex and body measurements demonstrated no significant difference between sexes but a highly significant ...
Schugar Rebecca C RC Department of Medicine, Center for Cardiovascular Research, Washington University, St. Louis, MO, - - 2014
Exploitation of protective metabolic pathways within injured myocardium still remains an unclarified therapeutic target in heart disease. Moreover, while the roles of altered fatty acid and glucose metabolism in the failing heart have been explored, the influence of highly dynamic and nutritionally modifiable ketone body metabolism in the regulation of ...
Kamath Deepak Y DY Division of Clinical Research & Training, St John's Research Institute, Bengaluru, - - 2014
There is a need to evaluate and implement cost-effective strategies to improve adherence to treatments in coronary heart disease. There are no studies from low- to middle income countries (LMICs) evaluating trained community health worker (CHW)-based interventions for the secondary prevention of coronary heart disease. We designed a hospital-based, open ...
Simonyi Gábor G Metabolic Center, Szent Imre Teaching Hospital, Budapest, - - 2014
Various ECG abnormalities are commonly observed in obesity and in metabolic syndrome. Some of these abnormalities are caused by the pushed-up position of the diaphragm due to obesity and others occur as a result of the complications of the condition. The position of the R wave may change, various arrhythmias ...
Binnetoğlu Fatih Köksal FK Department of Pediatric Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale-Turkey. - - 2014
To evaluate the left venticular myocardial deformation parameters in normotensive obese children and adolescents by using 2D speckle tracking echocardiography. This observational cross-sectional study included 69 children and adolescents (aged between 10-18), 38 were normotensive obese and 31 were normal weighted. All children underwent detailed two- dimentional, Doppler and two-dimentional ...
Kim Eung Gyu EG From the Departments of *Neurology and †Plastic and Reconstructive Surgery, Baik Hospital, Inje University, Busan, - - 2014
We report a case of a 23-year-old man with cerebral infarction and permanent visual loss after injection of a hyaluronic acid gel filler for augmentation rhinoplasty. The patient was admitted to the hospital with complaints of loss of vision in the right eye, facial paralysis on the right side, and ...
Yang Li-Li LL Department of Neurology, Peking University First Hospital Beijing, China ; Department of Neurology, The Daqing Oil Field General Hospital Daqing, - - 2014
The clinical manifestation of acute corpus callosum (CC) infarction is lack of specificity and complex, so it is easily missed diagnosis and misdiagnosis in the early stage. The present study aims to describe the clinical features of the acute CC infarction. In this study, 25 patients with corpus callosum infarction ...
Held Matthias M Medical Mission Hospital, Academic Teaching Hospital, Julius Maximilian University of Würzburg, Department of Internal Medicine, Würzburg, - - 2014
The prevalence of obesity is rising. Obesity can lead to cardiovascular and ventilatory complications through multiple mechanisms. Cardiac and pulmonary function in asymptomatic subjects and the effect of structured dietary programs on cardiac and pulmonary function is unclear. To determine lung and cardiac function in asymptomatic obese adults and to ...
Wykrętowicz Mariusz M Department of Radiology, University School of Medicine, Poznań, - - 2014
Left ventricular mass (LVM) is correlated with body composition and central hemodynamics as well as kidney function. Recently, fat-free mass has been considered to be more strongly correlated with LVM in comparison to other descriptors of fatness. We therefore address the question of whether comprehensive descriptors of fatness, central hemodynamics ...
Xu Jingjia - - 2014
The presence, size, and distribution of ischemic tissue bear significant prognostic and therapeutic implication for ventricular arrhythmias. While many approaches to 3D infarct detection have been developed via electrophysiological (EP) imaging from noninvasive electrocardiographic data, this ill-posed inverse problem remains challenging especially for septal infarcts that are hidden from body-surface ...
Park Hae-Young Lopilly HY Department of Ophthalmology and Visual Science, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, - - 2013
The objective of this study was to determine whether transneuronal retrograde degeneration (TRD) of the retinal ganglion cells (RGCs) could be detected by optical coherence tomography (OCT) in humans with lesions other than of the occipital lobe or visual cortex. In addition, whether laterality and severity of retinal nerve fiber ...
Wang Ning-Ping NP Cardiovascular Research Laboratory, Mercer University School of Medicine, Savannah, GA 31404, - - 2012
Curcumin, the natural yellow pigment extracted from the rhizomes of the plant curcuma longa, has been demonstrated to exhibit a variety of potent beneficial effects, acting as an antioxidant, anti-inflammatory and anti-fibrotic. In this study we tested the hypothesis that curcumin attenuates maladaptive cardiac repair and improves cardiac function after ...
Piktel Joseph S - - 2012
Although the majority of sudden cardiac arrests occur in patients with ischemic heart disease, the effect of therapeutic hypothermia on arrhythmia susceptibility during acute global ischemia is not well understood. While both ischemia and severe hypothermia are arrhythmogenic, patients undergoing therapeutic hypothermia do not have an increase in arrhythmias, despite ...
Warren John B - - 2012
To quantify the value of a medical therapy the benefits are weighed against the risks. Effectiveness is defined by objective evidence from predefined endpoints. This benefit is offset against the disadvantage of adverse events. The safety assessment is usually a subjective summary of concerns that can often be neither confirmed ...
Escudero Carolina - - 2012
Arrhythmias are an important cause of morbidity and mortality in children. Despite recent technological advances in treatment, pharmacologic therapy remains the most common treatment modality for pediatric arrhythmias. The choice of antiarrhythmic agent, the duration of therapy, and the dosing schedule depend on multiple factors including the recurrence risk and ...
Li Jingyuan J Department of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095-7115, - - 2012
We have recently shown that postischemic administration of intralipid protects the heart against ischemia-reperfusion injury. Here we compared the cardioprotective effects of intralipid with cyclosporine-A, a potent inhibitor of the mitochondrial permeability transition pore opening. In vivo rat hearts or isolated Langendorff-perfused mouse hearts were subjected to ischemia followed by ...
Betensky Brian P - - 2012
BACKGROUND: Defining the arrhythmogenic substrate is essential for successful ablation of scar-related ventricular tachycardia (VT). The visual characteristics of endocardial ischemic scar have not been described in vivo. The goal of this study was to 1) quantify the visual characteristics of normal tissue, scar border zone and dense scar in ...
Maier Lars S - - 2012
The late Na current is of pathophysiological importance for the heart. Ranolazine is an innovative anti-ischemic and antianginal agent that inhibits the late Na current, thereby reducing the Na-dependent Ca-overload, which improves diastolic tone and oxygen handling during myocardial ischemia. In addition, ranolazine seems to exert beneficial effects on diastolic ...
Rifki Oktay F - - 2012
Stress-induced hypertrophic growth of the myocardium is a pathogenetic milestone in the progression of heart failure. Some evidence suggests that suppression of pathological cardiac hypertrophy per se is a viable target for therapeutic intervention, and cardiomyocyte autophagy is an attractive mechanism for consideration as a means of controlling the hypertrophic ...
Shen Deliang D Cedars-Sinai Heart Institute, Los Angeles, CA 90048, - - 2012
Despite mounting pre-clinical and clinical evidence of the beneficial effects of cell-based therapy, optimal cell dosing and delivery approaches have not been identified. Cardiospheres are self-assembling three-dimensional (3D) microtissues formed by cardiac stem cells and supporting cell types. The ability of cardiospheres to augment cardiac function has been demonstrated in ...
Callea Giuditta - - 2012
Abstract. Aims: The aims of this review are to identify and evaluate studies exploring the cost-effectiveness of primary angioplasty (PPCI) vs. thrombolysis (TL) for treating acute myocardial infarction (AMI). Methods and results: A comprehensive free-text searching identified economic evaluation studies that were reviewed with respect to their effectiveness data, identification, ...
Osadchii Oleg E - - 2012
PURPOSE: Dofetilide is class III antiarrhythmic agent which prolongs cardiac action potential duration because of selective inhibition of I (Kr), the rapid component of the delayed rectifier K(+) current. Although clinical studies reported on proarrhythmic risk associated with dofetilide treatment, the contributing electrophysiological mechanisms remain poorly understood. This study was ...
Tzeis Stylianos - - 2012
Pharmacological management of cardiac arrhythmias is limited by the reduced availability of safe and effective antiarrhythmic agents. Ranolazine is an agent currently used for the treatment of angina, which inhibits transmembrane ionic currents involved in several phases of the action potential in both the atrial and the ventricular cells. Due ...
Kumfu Sirinart - - 2012
Iron-overload induced cardiomyopathy is a major cause of morbidity and mortality in thalassemic patients. Previous studies suggest that cardiac mitochondrial dysfunction may be involved in the pathogenesis of cardiomyopathy in thalassemia. We tested the hypothesis that iron overload causes dysfunction of cardiac mitochondria isolated from thalassemic mice. Cardiac mitochondria were ...
De Meyer Simon F SF Immune Disease Institute, Boston, MA 02115, - - 2012
Coronary heart disease is a major cause of death in the western world. Although essential for successful recovery, reperfusion of ischemic myocardium is inevitably associated with reperfusion injury. To investigate a potential protective role of ADAMTS13, a protease cleaving von Willebrand factor multimers, during myocardial ischemia/reperfusion, we used a mouse ...
Krebs Paul - - 2012
QUESTION Does use of varenicline for tobacco cessation increase risk for treatment-emergent, cardiovascular (CV) serious adverse events in adult tobacco users? REVIEW SCOPE Included studies compared varenicline with an inactive control in current adult tobacco users and reported adverse events. The primary outcome was treatment-emergent, CV serious adverse events defined ...
Lygate Craig A CA Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK. - - 2012
Increasing energy storage capacity by elevating creatine and phosphocreatine (PCr) levels to increase ATP availability is an attractive concept for protecting against ischaemia and heart failure. However, testing this hypothesis has not been possible since oral creatine supplementation is ineffectual at elevating myocardial creatine levels. We therefore used mice overexpressing ...
Lim Hoong Sern - - 2012
Contemporary devices include sophisticated algorithms specifically designed to minimize ventricular pacing, with the intention of limiting the patient's exposure to potentially deleterious effects of right ventricular pacing. The added complexity and adverse effects (some potentially life-threatening) associated with the use of these algorithms are often under-appreciated. The operational features, efficacy, ...
Birner Christoph C Klinik und Poliklinik für Innere Medizin II-Kardiologie, Universitätsklinikum Regensburg, 93042, Regensburg, Germany. - - 2012
Vasopeptidase inhibition (VPI), a therapeutic strategy by dual inhibition of both ACE and neutral endopeptidase 24.11, has not shown a prognostic benefit over ACE inhibition in chronic severe heart failure (CHF). Nevertheless, the effects of early treatment by VPI on cardiac remodelling have not been well assessed. We analysed the ...
Cao Zhijuan Z Department of Surgery, East Tennessee State University, Johnson City, TN 37614, - - 2013
Toll-like receptors (TLRs) have been implicated in myocardial ischemia/reperfusion (I/R) injury. The TLR9 ligand, CpG-ODN has been reported to improve cell survival. We examined effect of CpG-ODN on myocardial I/R injury. Male C57BL/6 mice were treated with either CpG-ODN, control-ODN, or inhibitory CpG-ODN (iCpG-ODN) 1h prior to myocardial ischemia (60min) ...
Aggarwal Nitin T NT Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison, WI 53792, - - 2013
Reactive oxygen species (ROS) have been associated with various human diseases, and considerable attention has been paid to investigate their physiological effects. Various ROS are synthesized in the mitochondria and accumulate in the cytoplasm if the cellular antioxidant defense mechanism fails. The critical balance of this ROS synthesis and antioxidant ...
Naggar Isaac - - 2012
The sympathetic and parasympathetic divisions of the autonomic nervous system modulate cardiac rhythm and the probability of arrhythmia occurrence. Both increased sympathetic drive and hypoxia increase the likelihood for ventricular fibrillation (VF). Vagus nerve stimulation (VNS) can protect from fatal arrhythmias via cholinergic and nitrergic action. We sought to determine ...
Park Min - - 2012
Cardiovascular disease, including heart failure, is a principal cause of death in individuals with obesity and diabetes. However, the mechanisms of obesity- and diabetes-induced heart disease are multifaceted and remain to be clearly defined. Of relevance to this review, there is currently great research and clinical interest in the endocrine ...
Eiby Yvonne Ann - - 2012
Aims: Low systemic blood flow occurs in up to 30% of infants born at less than 30 weeks gestation. It is associated with increased morbidity and mortality and current treatments are ineffective in 40% of cases. The aim of this study was to assess the ability of the preterm heart ...
Heo Kyung-Sun - - 2012
Recently, the crucial role of GLP-1 in cardiovascular disease has been suggested by both preclinical and clinical studies. In vivo and in vitro studies have demonstrated cardio-protective effects of GLP-1 by activating cell survival signal pathways, which have greatly reduced ischemia/reperfusion injury and also cardiac dysfunction in various congestive heart ...
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