Search Results
Results 401 - 450 of 2276
< 4 5 6 7 8 9 10 11 12 13 14 >
Keller Till - - 2011
Introduction of highly sensitive troponin assays into clinical practice has substantially improved the evaluation of patients with chest pain. To evaluate the diagnostic performance of a highly sensitive troponin I (hsTnI) assay compared with a contemporary troponin I (cTnI) assay and their serial changes in the diagnosis of acute myocardial ...
Gupta Ashish A Department of Medicine, Cardiology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland, - - 2012
ATP is required for normal cardiac contractile function, and it has long been hypothesized that reduced energy delivery contributes to the contractile dysfunction of heart failure (HF). Despite experimental and clinical HF data showing reduced metabolism through cardiac creatine kinase (CK), the major myocardial energy reserve and temporal ATP buffer, ...
Zhao Heng - - 2011
The author reviews the protective effects of ischemic postconditioning, a recently emerging strategy with broad implications in the search for new treatments in stroke and myocardial ischemic injury. Ischemic postconditioning, which refers to a series of brief ischemia and reperfusion cycles applied immediately at the site of the ischemic organ ...
Kolseth Solveig Moss - - 2011
OBJECTIVESLevosimendan is a novel inotropic agent claimed to improve myocardial contractility by a calcium-sensitizing effect. Our aim was to evaluate dose-dependent effects of levosimendan on left ventricular (LV) contractility and energetic properties in an acute, ischaemic heart failure porcine model.METHODSSix pigs were used in an anaesthetized in vivo open-chest model. ...
Elsenberg Ellen H A M - - 2011
Toll-Like Receptor (TLR) activation induced inflammatory responses are important in the progression of atherosclerosis. We previously showed that TLR-dependent leukocyte responsiveness is acutely attenuated following percutaneous coronary intervention or vascular surgery. Furthermore, cytokine release following whole blood TLR-2 and -4 stimulation is negatively correlated with fractional flow reserve, suggesting that ...
Bank Alan J - - 2011
Cardiac pacing is a common treatment option for patients with sick sinus syndrome or atrioventricular block, with the ventricular pacing lead often secured in the convenient right ventricular (RV) apical location. While RV pacing reduces symptoms and limitations associated with heart block, it may have detrimental effects on cardiac structure ...
Ristagno Giuseppe - - 2011
OBJECTIVE: The placement of defibrillation pads at ideal anatomical sites is one of the major determinants of transthoracic defibrillation success. However, the optimal pads position for ventricular defibrillation is still undetermined. In the present study, we compared the effects of two different pads positions on defibrillation success rate in a ...
Bozkurt Biykem - - 2012
It is unclear whether improvement in left ventricular (LV) ejection fraction (LVEF) following treatment with a combined α(1),β(1),β(2)-blockade can be attributed to improvement in LV contractility, to a reduction in afterload, and/or to improvements in LV remodeling and chamber size. We aimed to examine whether the observed improvement in LVEF ...
Camm A John - - 2011
Atrial fibrillation is an increasingly common arrhythmia which is associated with a substantial burden of cardiovascular disease. The arrhythmia is mostly treated with pharmacological therapy, although some interventional techniques such as left atrial ablation, atrioventricular nodal ablation plus pacemaker implantation, and left atrial appendage occlusion or excision are gaining popularity. ...
Issa Aurora - - 2011
The conventional dobutamine (Dob) stress protocol for myocardial perfusion scintigraphy (MPS) is long, with frequent adverse effects, and generally requires atropine injection to reach target heart rate. Atropine is usually administered at the end of the protocol, when adverse effects are more frequent. Earlier atropine injection may be useful to ...
He Ting - - 2011
AIM: To investigate the in vivo and in vitro protective effects of pentamethylquercetin (PMQ), a member of polymethoxy flavonoids (PMFs), on cardiac hypertrophy. METHODS: An in vivo cardiac hypertrophy model established by abdominal aorta banding technique in rats was treated with PMQ in increasing dosages (2.5, 5, and 10 mg·kg(-1)·d(-1)). An ...
Iravanian Shahriar - - 2011
AimsAtrial fibrillation (AF)-induced electrical remodelling causes shortening of refractory period and slowing of conduction velocity. During the course of catheter ablation of AF, there are often transitions from AF to left atrial flutter (AFL) and from faster to slower AFL. The purpose of this study was to characterize the time ...
Aldous Sally J - - 2012
Abstract Background: Many papers evaluating high sensitivity troponin assays make the diagnosis of myocardial infarction based on conventional troponin assays in clinical use at the time of recruitment. Such analyses often do not show superiority of high sensitivity assays compared with contemporary assays meeting precision guidelines. Methods: Three hundred and ...
Johnson Carolyn M - - 2011
Focal Initiation of Ventricular Tachycardia in Ischemic HF.  Introduction: To define the role of focal and reentrant mechanisms underlying nonsustained (NSVT) and sustained ventricular tachycardia (SuVT) induced by programmed stimulation, 3-dimensional cardiac mapping was performed in 8 dogs with heart failure (HF) created by multiple intracoronary microsphere embolizations. Methods and ...
Durmus Tahir - - 2011
OBJECTIVES: To compare 0.15 mmol/kg gadobutrol with 0.20 mmol/kg gadopentetate dimeglumine with regard to late gadolinium enhancement (LGE) of infarcted myocardium at magnetic resonance (MR) imaging. MATERIALS AND METHODS: Twenty patients with history of chronic myocardial infarction underwent 2 cardiac MR examinations at 1.5 Tesla. For the evaluation of myocardial ...
Olson Aaron K - - 2012
Triiodothyronine (T3) supplementation improves clinical outcomes in infants after cardiac surgery using cardiopulmonary bypass by unknown mechanisms. We utilized a translational model of infant cardiopulmonary bypass to test the hypothesis that T3 modulates pyruvate entry into the citric acid cycle (CAC), thereby providing the energy support for improved cardiac function ...
Hynes Brian - - 2011
AimsWe have previously reported the cardioprotective effects of endothelial progenitor cell (EPC)-conditioned media (CM) therapy post-myocardial infarction (MI). In the present study, we have determined the insulin-like growth factor-1 (IGF-1) contribution to EPC CM effects on cardiomyocyte survival, contractility, and angiogenesis in vivo.Methods and resultsConditioned media from porcine EPC were ...
Catena Cristiana - - 2012
Experimental and clinical studies indicate that exposure to high aldosterone concentrations causes cardiac damage independent of the blood pressure level. In recent years, it has become clear that the effects of aldosterone on the heart are mediated by actions on a variety of cell types and intracellular mechanisms that contribute ...
Porto Italo - - 2011
Aims: To assess the main predictors and significance of filter no-reflow (FNR) in protected saphenous vein graft (SVG) percutaneous coronary intervention (PCI) and the effect of two different filter-based devices on FNR incidence. The phenomenon of FNR has been described as a transient impairment of blood flow due to debris ...
Rane Aboli A - - 2011
The first review on biomaterials for the treatment of myocardial infarction (MI) was written in 2006. In the last 5 years, the general approaches for biomaterial treatment of MI and subsequent left ventricular remodeling remain the same, namely, left ventricular restraints, epicardial patches, and injectable therapies. Nonetheless, there have been ...
Kienesberger Petra C PC Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, - - 2012
Alterations in myocardial triacylglycerol content have been associated with poor left ventricular function, suggesting that enzymes involved in myocardial triacylglycerol metabolism play an important role in regulating contractile function. Myocardial triacylglycerol catabolism is mediated by adipose triglyceride lipase (ATGL), which is rate limiting for triacylglycerol hydrolysis. To address the influence ...
Mohsin Sadia S San Diego State University, San Diego, CA, - - 2011
Treatment strategies for heart failure remain a high priority for ongoing research due to the profound unmet need in clinical disease coupled with lack of significant translational progress. The underlying issue is the same whether the cause is acute damage, chronic stress from disease, or aging: progressive loss of functional ...
Kadner Karen - - 2011
Biomaterials are increasingly being investigated as a means of reducing stress within the ventricular wall of infarcted hearts and thus attenuating pathological remodelling and loss of function. In this context, we have examined the influence of timing of delivery on the efficacy of a polyethylene glycol hydrogel polymerised with an ...
Ramond Amandine - - 2011
We have previously shown that chronic intermittent hypoxia (IH), a component of the obstructive sleep apnea syndrome, increases heart sensitivity to infarction. We investigate here the deleterious mechanisms potentially involved in the IH-induced infarction aggravation, investigating the role of oxidative stress. Male Wistar rats were subjected to chronic IH or ...
Onishi Anna - - 2011
To assess whether sevoflurane preconditioning is associated with inhibition of mitochondrial permeability transition pore (MPTP), the effects of sevoflurane were compared with those of cyclosporine A, a known inhibitor of MPTP opening. Isolated perfused guinea pig hearts underwent 30min global ischemia and 120min reperfusion (control). Sevoflurane preconditioning was elicited by ...
Dvir Danny - - 2011
We describe a patient with severe aortic stenosis who underwent CoreValve (Medtronic) implantation and presented several days later with a tachyarrhythmic episode. The electrocardiographic features of the arrhythmia were compatible with left-ventricular outflow tract ventricular-tachycardia. The life-threatening event was not associated with ischemia or an electrolyte disorder and was not ...
Chen Wei-Ta - - 2011
Heat stroke is defined by central nervous system abnormalities and failure of proper maintenance of thermoregulation as a result of high core body temperature ensuing from exposure to high environmental temperatures or strenuous exercise. Common complications include acute respiratory distress syndrome, disseminated intravascular coagulation, acute renal injury, hepatic injury, and ...
Nakashima Takashi - - 2011
A 78-year-old female received a cardiac resynchronization therapy-defibrillator equipped with an intrathoracic impedance (ITI) monitor and amiodarone therapy was initiated. A massive and long-lasting decrease in ITI occurred without heart failure (HF) deterioration. Pericardial effusion secondary to amiodarone-induced hypothyroidism may have caused the impedance reduction.
Harris Carolyn A - - 2011
ABSTRACT: The treatment of hydrocephalus by cerebrospinal fluid (CSF) shunting is plagued by ventricular catheter obstruction.Shunts can become obstructed by cells originating from tissue normal to the brain or by pathological cells in the CSF for a variety of reasons.In this review, the authors examine ventricular catheter obstruction and identify ...
Ishida Kentaro - - 2011
BACKGROUND: Statin treatment has been shown to improve coronary endothelial function, irrespective of lipid-lowering effects. This study's aim was to elucidate the effects of statin treatment on coronary microvascular dysfunction and left ventricular remodeling in acute myocardial infarction (AMI) patients. METHODS: Thirty-five patients undergoing successful reperfusion following AMI were assigned ...
Ando Masahiko - - 2011
OBJECTIVE: Recent developments in adjunctive therapy have enabled us to remove once-implanted left ventricular assist devices. For successful device removal, appropriate patient selection and precise evaluation of cardiac function are essential. However, with rotary pumps, pump weaning inevitably creates diastolic retrograde pump flow, and this flow may overload the native ...
Grande Juan Manuel - - 2011
Increases of pacing threshold stimulation are well documented with different antiarrhythmic drugs, but not with amiodarone. We report a case of a patient with dual-chamber pacing, with stable thresholds on repeated measurements on the last year, who presented severe increase of atrial pacing threshold resulting in loss of atrial capture ...
Mourouzis Iordanis - - 2011
The present study explored the effects of thyroid hormone (TH) treatment on post-ischemic cardiac function and potential implicated mechanisms. Acute myocardial infarction (AMI) was induced in mice by coronary artery ligation while sham-operated animals served as controls. This procedure resulted in a marked depression of cardiac function and significant reduction ...
Yang Feng Hua - - 2011
The Z-disc protein CapZ has historically been classified as a structural element, anchoring sarcomeric actin. Our previous work expanded its role to include signal transduction, as CapZ transgenic myofilaments are less sensitive to protein kinase C (PKC). Myocardial PKC has paradoxical effects, mediating both preconditioning and ischemia-reperfusion (IR) injury. Our ...
Farraj Aimen K - - 2012
Ozone (O₃) is a well-documented respiratory oxidant, but increasing epidemiological evidence points to extrapulmonary effects, including positive associations between ambient O₃ concentrations and cardiovascular morbidity and mortality. With preliminary reports linking O₃ exposure with changes in heart rate (HR), we investigated the hypothesis that a single inhalation exposure to O₃ ...
Angelos Mark G - - 2011
INTRODUCTION: Rapid post-ischemic re-oxygenation is necessary to minimize ischemic injury, but itself can induce further reperfusion injury through the induction of reactive oxygen species. Utilization of oxygen within the cell primarily occurs in the mitochondria. The objective of this study was to determine heart mitochondrial function after 1 h of ...
Gálvez-Montón Carolina - - 2011
BACKGROUND: Myocardial salvage after coverage with a fat flap was recently demonstrated in acute coronary occlusion. The effect of this novel therapeutic strategy on a chronic myocardial scar is unknown. METHODS: Myocardial infarction (MI) was induced by coil deployment in the mid circumflex artery in the swine model. Two weeks ...
Kumar Andreas - - 2011
The purpose of this study was to validate T2*-weighted cardiac magnetic resonance (T2*-CMR) for the detection and quantification of reperfusion hemorrhage in vivo against an ex vivo gold standard, and to investigate the relationship of hemorrhage to microvascular obstruction, infarct size, and left ventricular (LV) functional parameters. Hemorrhage can contribute ...
Ahmad Omar - - 2011
Background: A blood test that quantified the extent of brain damage following ischaemic stroke might be a useful surrogate outcome measure in trials of acute stroke treatments. Measures of neuronal and glial damage, such as neuron-specific enolase (NSE), glial fibrillary acidic protein, tau-protein, myelin-basic protein and S100-β are potential candidate ...
Smeele K M - - 2011
Rationale Isoforms I and II of the glycolytic enzyme hexokinase (HK) are known to associate with mitochondria. It is unknown whether mitochondrially bound hexokinase (mitoHK) is mandatory for ischaemic preconditioning and normal functioning of the intact, beating heart. Objective We hypothesise that reducing mitoHK abrogates ischaemic preconditioning and disrupts myocardial ...
Dehina L - - 2011
Myocardial ischaemia affects mitochondrial function leading to ionic imbalance and susceptibility to ventricular fibrillation. Trimetazidine (TMZ), a metabolic agent, is clinically used as an anti-anginal therapy. This study was conducted to compare the effect of Vastarel 20 mg IR (immediate release) and Vastarel 35 mg MR (modified release), two bioequivalent ...
Kuka J - - 2011
Mildronate is a cardioprotective agent whose mechanism of action is based on decrease in L-carnitine concentration in heart tissue and concomitant decrease in fatty acid metabolism. The present study was undertaken to highlight the role of mitochondrial energy pathways in the anti-infarction mechanism of mildronate. Male Wistar rats received water ...
Naumenko S E - - 2011
We studied the effect of inhibition of norepinephrine reuptake during the reperfusion period on the size of infarction zone after focal myocardial ischemia and under conditions of ischemic postconditioning. In groups 1 and 2, 30-min occlusion of the left coronary artery followed by 120-min reperfusion was performed. In groups 3 ...
Simmons K L - - 2011
Concerns have been raised regarding the cardiovascular safety of muscarinic receptor antagonists, such as Ipratropium bromide for use in asthmatic patients with underlying heart disease.1 2 The aims of this study were to determine the involvement of Ipratropium at the muscarinic receptor on myocardial ischaemia/reperfusion injury in isolated adult cardiomyocyte ...
Huang Chien-Hua - - 2011
AIM OF STUDY: Significant myocardial dysfunction and high mortality occur after whole-body ischaemia-eperfusion injuries in the post-cardiac arrest status. The inhibition of mitochondrial permeability transition pore (mPTP) opening during ischaemia-reperfusion can ameliorate injuries in the specific organs. We investigated the effect and therapeutic window of pharmacological inhibition of mPTP opening ...
Zhao Ye - - 2011
Abstract Background. Selective retrograde coronary venous bypass (SRCVB) may be a promising treatment for patients with advanced coronary artery disease (CAD). The aim of this study is to investigate the effect of SRCVB on plasma endothelial factor levels in dog myocardial ischemic model, and explore the possible mechanisms. Methods. 24 ...
Perasso Luisa - - 2011
Creatine (Cr) is essential in safeguarding ATP levels and in moving ATP from its production site (mitochondria) to the cytoplasmic regions where it is used. Moreover, it has effects unrelated to energy metabolism, such as free radical scavenging, antiapoptotic action, and protection against excitotoxicity. Recent research has studied Cr-derived compounds ...
Dongó E - - 2011
Myocardial infarction is responsible for the majority of cardiovascular mortality and the pathogenesis of myocardial damage during and after the infarction involves reactive oxygen species. Serious efforts are under way to modulate the developing ischemia/reperfusion injury and recently the use of hydrogen sulfide (H2S) emerged as a new possibility. H2S ...
Bell R M - - 2011
While matrix-metalloproteinase (MMP) inhibition protects against myocardial ischaemia/reperfusion injury, the mechanisms are poorly understood. We hypothesised that this cardioprotection is independent of mitochondrial permeability transition pore (mPTP) inhibition, the end-effector of ischaemic postconditioning (iPOC). In ex vivo and in vivo mouse hearts, we investigated whether the MMP inhibitor, ilomostat (0.25 ...
Schuleri Karl H - - 2011
The aim of this study was to use multidetector computed tomography (MDCT) to assess therapeutic effects of myocardial regenerative cell therapies. Cell transplantation is being widely investigated as a potential therapy in heart failure. Noninvasive imaging techniques are frequently used to investigate therapeutic effects of cell therapies in the preclinical ...
< 4 5 6 7 8 9 10 11 12 13 14 >