Search Results
Results 1 - 50 of 2062
1 2 3 4 5 6 7 8 9 10 >
Izumi-Nakaseko Hiroko H Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16, Omori-nishi Ota-ku, Tokyo 143-8540, - - 2014
An inversion of electro-mechanical coupling; namely, mechanical relaxation which precedes electrical repolarization, has been proposed as a surrogate marker to predict the occurrence of drug-induced arrhythmias. The present study was designed to qualitatively and quantitatively clarify the effects of rapidly activating delayed rectifier K(+) current (IKr)-selective blockade by E-4031 on ...
McGarvey Jeremy R JR University of - - 2014
A treatment target for progressive LV remodeling prevention following myocardial infarction (MI) is to affect structural changes directly within the MI region. One approach is through targeted injection of biocomposite materials, such as calcium hydroxyapatite (CHAM), into the MI region. In this study, the effects of CHAM injections upon key ...
Yamakawa Kentaro - - 2014
Vagal nerve stimulation (VNS) has been proposed as a cardio-protective intervention. However, regional ventricular electrophysiological effects of VNS are not well characterized. The purpose of this study was to evaluate effects of right and left VNS on electrophysiological properties of the ventricles and hemodynamic parameters. In Yorkshire pigs, a 56-electrode ...
Dohi Kaoru K Department of Cardiology and Nephrology, Mie University Graduate School of - - 2014
Fluid management is of paramount importance in the treatment strategy of heart failure (HF), but the therapeutic efficacy of loop diuretic-based treatment for HF patients is limited by insufficient response and adverse effects. Clinical data establishing the efficacy and safety of tolvaptan, a selective oral vasopressin V2 receptor antagonist that ...
Xie Juan J The Trauma Emergency & Critical Care Medicine Center, the Fifth People's Hospital of Shanghai, Fudan - - 2014
Background: Air pollution can be a contributing cause to the development and exacerbation of coronary heart disease (CHD), but there is little knowledge about the acute effects of air pollution on different clinical subtypes of CHD.Methods: We conducted a time-series study to investigate the association of air pollution (particulate matter ...
Khori Vahid V Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, - - 2014
Simvastatin (SV) leads to reduction of ventricular rhythm during atrial fibrillation on rabbit atrioventricular (AV) nodes. The aim of our study was (i) to determine the frequency-dependent effects of SV in a functional model, and (ii) to assess the effects of SV to suppress experimental atrioventricular nodal reentrant tachycardia (AVNRT). ...
Gullo Caio Eduardo - - 2014
Heart Failure (HF) is a progressive and fatal disorder, which ranks among the major public health problems in Brazil and worldwide. However, survival for patients who developed the syndrome after myocardial infarction (MI) enhanced significantly, as a result of an improvement of pharmacological therapies. A medical breakthrough was the discovery ...
Dlesk Anton A 5th Department of Internal Medicine, Medical Faculty of Commenius University and University Hospital, Ružinovská 6, 826 06, Bratislava, Slovakia, - - 2014
The aim of the study was to evaluate the effect of growth hormone (GH) replacement therapy on the morphological and functional changes in the left ventricle (LV) in patients with GH deficiency (GHD). Patients with adult-onset GHD were treated with GH. Transthoracic echocardiography was performed at baseline and after 6 ...
Hodcroft Christopher J CJ Department of Acute Medicine, Royal Glamorgan Hospital, Llantrisant, United - - 2014
The use of cannabis is not usually regarded as a risk factor for acute coronary syndrome. However, several cases of myocardial infarction (MI) associated with cannabis use have been reported in the scientific literature. The etiology of this phenomenon is not known. To present a case of cannabis-associated MI in ...
Cuspidi Cesare C aDepartment of Health Science, University of Milano-Bicocca bIstituto Auxologico Italiano cDepartment of Clinical Sciences and Community Health, University of Milano and Fondazione Policlinico di Milano, Milan, Italy dUniversity Clinical Hospital Centre 'Dragisa Misovic', Belgrade, Serbia eIstituto di Ricerche a Carattere Scientifico Multimedica, Sesto San Giovanni, Milan, - - 2014
Left ventricular (LV) changes associated with obesity, including LV hypertrophy and impaired LV function, have been shown to be reverted by bariatric surgery. Little is known about the effects of bariatric procedures on right ventricle (RV). We analyzed the literature in order to provide a comprehensive information on RV structural ...
Babba M M Coventry University, Biomolecular and Sport Sciences, Coventry, United - - 2014
Recent studies have emphasised an important role for Artemisinin as an effective and potent anticancer cancer drug, with significantly less adverse effects in comparison to traditional chemotherapeutic agents. Most of the widely used cancer treatments are limited in use due to their dose dependent cardiotoxicity. Artemisinin has been found to ...
Duicu O M OM Department of Pathophysiology "Victor Babes" University of Medicine and Pharmacy, Timisoara, - - 2014
Modulation of mitochondrial function in the settings of ischemia/reperfusion (I/R) injury represents a major therapeutic target of pharmacological agents able to reduce the cell death at reperfusion. The aim of this study was to compare the effects of acute administration of magnesium orotate (MO), MgCl2, orotic acid (OA) with those ...
Rodriguez-Sinovas A A Institut de Recerca Hospitals Vall d'Hebron, Lab. Cardiologia Experimental, Barcelona, - - 2014
Ventricular arrhythmias are a common clinical manifestation in patients with acute myocardial infarction submitted to coronary revascularizaton. Reperfusion arrhythmias have been associated with successful myocardial reperfusion during thrombolytic therapy, but they have been also suggested to be a marker of large infarct size and worse prognosis. Ischemic postconditioning (PostC) has ...
Goshovska Y Y Bogomoletz Institute of Physiology, Kiev, - - 2014
Hydrogen sulfide (H2S) is endogenously generated from L-cysteine by cystathionine-gamma-lyase (CSE). H2S donors demonstrate cardioprotective properties, however, role of endogenous H2S is not revealed. We hypothesized that exogenous L-cysteine may stimulate H2S synthesis and mediate cardioprotection. At the same time L-cysteine might be engaged in gluthatione production. Thus, the aim ...
Bharti S S All India Institute of Medical Sciences, New Delhi, - - 2014
We established previously that Crocus sativus and its carotenoid crocin protects the myocardium via augmenting the endogenous antioxidant defense system. Since, heat shock protein70 (Hsp70) actively participates in shielding the cell from oxidative stress, programmed or necrotic cell deaths; we hypothesized that Hsp70 might be the actual mediator behind the ...
Khaliulin I I University of Bristol, Bristol, United - - 2014
We have recently discovered that consecutive treatment of heart with isoproterenol and adenosine (Iso/Ade treatment), with a high dose of Iso (200 nM), confers strong protection against ischemia and reperfusion injury. Here we investigate whether this effect can be achieved at clinically relevant dose of Iso and identify the mechanism ...
Szucs G G Cardiovascular Research Group, Department of Biochemistry, University Of Szeged, Szeged, - - 2014
We have previously reported that chronic oral treatment with the HMG-CoA reductase inhibitor lovastatin shows cardioprotection but interacts with the cardioprotective effect of postconditioning and that farnesol, a key intermediate of the mevalonate pathway, is cardioprotective possibly via enhancement of protein geranylgeranylation. Here we studied the interaction of the HMG-CoA ...
Muntean D D University of Medicine Victor Babes, Pathophysiology, Timisoara, - - 2014
Whether cardioprotective strategies are still effective in elderly is a matter of debate. The present study was purported to assess the persistence of the protective effects of pharmacological agents targeting mitochondria in old Sprague-Dawley rats. Methods. To this aim isolated hearts from old (20-24 mo) and adult (4-6 mo) animals ...
Kisvari G G University of Szeged, Department of Pharmacology and Pharmacotherapy, Szeged, - - 2014
In a previous study we have shown that a single dose of simvastatin markedly reduced the severity of ventricular arrhythmias that resulted from a 25 min ischaemia and reperfusion (I/R) in anaesthetized dogs. This protection seems to involve the generation of nitric oxide (NO) via the activation of NO synthase ...
Markava I I Republican Scientific and Practical Centre of Cardiology, Minsk, - - 2014
The objective was to find out the value of the markers that reflect the pathophysiology of destabilization of ischemic heart disease in risk stratification and access the effectiveness of the secondary prevention. This prospective study included 180 hospitalized patients (M/F=120/60, 57±3) with UA and low to intermediate Grace score. End-points ...
Garcia-Prieto J J National Centre for Cardiovascular Research (CNIC), Atherothrombosis, Epidemiology and Imaging Department, Madrid, - - 2014
Beta3-adrenergic receptor (b3AR) stimulation reduces myocardial ischemia/reperfusion injury (IRI) in vivo. The aim of this study was to assess whether this effect is exerted directly in the cardiomyocytes and to investigate the role of the mPTP in this protection. Adult isolated and HL-1 cardiomyocytes were subjected to hypoxia/reoxygenation (H/R) in ...
Leon E E Cardiocentro "Ernesto Che Guevara", Santa Clara, - - 2014
To determine the synergistic effect of glycemia and leukocyte count by leukoglycemic index (LGI) on prognosis in patients with myocardial infarction with ST segment elevation (STEMI). Methods: A prospective longitudinal study of 233 patients diagnosed with STEMI who were admitted to a secondary hospital was performed. Clinical data and cardiac ...
Zhu Pengju P Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766 Jingshi Road, 250014, Jinan, - - 2014
Radiofrequency catheter ablation (RFCA) is an effective therapy for atrial fibrillation (AF). This study was designed to investigate the effects of RFCA on left ventricular (LV) structure and function in AF patients. A systematic literature search in MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed to identify ...
Estévez-Loureiro Rodrigo R Rodrigo Estévez-Loureiro, Armando Pérez de Prado, Carlos Cuellas, Norberto Alonso-Orcajo, Maria López-Benito, Felipe Fernández-Vázquez, Division of Cardiology, Complejo Asistencial Universitario de León (CAULE), 24071 Leon, - - 2014
Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction (STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the ...
Schmidt Michael Rahbek MR Michael Rahbek Schmidt, Kasper Pryds, Hans Erik Bøtker, Department of Cardiology, Aarhus University Hospital Skejby, 8200 Aarhus N, - - 2014
Myocardial infarction is a major cause of death and disability worldwide and myocardial infarct size is a major determinant of prognosis. Early and successful restoration of myocardial reperfusion following an ischemic event is the most effective strategy to reduce final infarct size and improve clinical outcome, but reperfusion may induce ...
Chevalier Julie J Chair of Health Systems, ESSEC Business School, Cergy-Pontoise, France. Electronic address: - - 2014
Atrial fibrillation is the main cause of stroke, but the risk can be reduced, usually with vitamin K antagonists (VKAs) such as warfarin. The RE-LY atrial fibrillation study demonstrated that the rates of stroke and systemic embolism with dabigatran (an oral direct thrombin inhibitor) were similar to or lower than ...
Liu Chao C Heart Center, The First Hospital of Hebei Medical University. Electronic address: - - 2014
Diuretic resistance in heart failure is defined as a state in which diuretic response is diminished or lost before the therapeutic goal of relief from congestion has been reached. Diuretic resistance is very common and is associated with poor outcomes. Over the past decade, several new drugs and devices targeting ...
Priester Tiffany T Cardiology Division, University of Utah, Salt Lake City, UT, - - 2014
Obesity is associated with elevated coronary artery calcium (CAC), a marker of coronary atherosclerosis that is strongly predictive of cardiovascular events. We evaluated the effects of marked weight loss achieved through Roux-en-Y gastric bypass surgery (GBS) on CAC scores. We performed echocardiography and computed tomography of the heart in 149 ...
Vaidya Anil - - 2014
Delayed diagnosis and treatment of Acute Myocardial Infarction (AMI) has a major adverse impact on prognosis in terms of both morbidity and mortality. Since conventional cardiac Troponin assays have a low sensitivity for diagnosing AMI in the first hours after myocardial necrosis, high-sensitive assays have been developed. The aim of ...
Ho Yi-Jin - - 2014
Caffeic acid phenethyl ester (CAPE) has been shown to protect the heart against ischemia/reperfusion (I/R) injury by various mechanisms including its antioxidant effect. In this study, we evaluated the protective effects of a CAPE analog with more structural stability in plasma, caffeic acid phenethyl amide (CAPA), on I/R injury in ...
Hansen Jan J Department of Biomedicine-Pharmacology, Aarhus University, University Park 1240, DK-8000, Aarhus C, - - 2014
The gut hormone glucagon-like peptide-1 (GLP-1) is an insulinotropic incretin with significant cardiovascular impact. Two classes of medication, GLP-1 analogues and DPP-4 inhibitors, have been developed that circumvent the rapid degradation of GLP-1 by the enzyme dipeptidyl peptidase-4 (DPP-4), both enhance the incretin effect and were developed for the treatment ...
Zhang Yanmin Y Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK; Heart Centre, Northwest Women's and Children's Hospital, Xi'an, 710003, P.R - - 2014
To test a hypothesis attributing arrhythmia in Brugada Syndrome to right ventricular (RV) outflow tract (RVOT) conduction abnormalities arising from Nav 1.5 insufficiency and fibrotic change. Arrhythmic properties of Langendorff-perfused Scn5a+/- and wild-type mouse hearts were correlated with ventricular effective refractory periods (VERPs), multi-electrode array (MEA) measurements of action potential ...
Masoumi Nafiseh N Department of Bioengineering, The Pennsylvania State University, University Park, PA, - - 2014
Cyclic flexure and stretch are essential to the function of semilunar heart valves and have demonstrated utility in mechanically conditioning tissue-engineered heart valves. In this study, a cyclic stretch and flexure bioreactor was designed and tested in the context of the bioresorbable elastomer poly(glycerol sebacate). Solid poly(glycerol sebacate) membranes were ...
Milojevic Ai A Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, - - 2014
To inform potential pathophysiological mechanisms of air pollution effects on cardiovascular disease (CVD), we investigated short-term associations between ambient air pollution and a range of cardiovascular events from three national databases in England and Wales. Using a time-stratified case-crossover design, over 400 000 myocardial infarction (MI) events from the Myocardial Ischaemia ...
Yoshino Takuya T T Yoshino, Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, - - 2014
Although persistent excessive actions of aldosterone have unfavorable effects on the cardiovascular system, primarily via mineralocorticoid receptor-dependent pathways, the pathophysiological significance of aldosterone cascade activation in heart diseases has not yet been fully clarified. We herein examined the effects of short-term aldosterone stimulation at a physiological dose on the cardiac ...
Marino Marcello M University of Pavia, Pavia, - - 2014
Platelet inhibition is the main goal of ancillary pharmacologic therapy during percutaneous coronary interventions (PCI). Thienopyridines and ticagrelor are oral drugs developed for this purpose. Cangrelor is an intravenous, non-thienopyridine antagonist of the P2Y12 receptor with a rapid, potent, predictable, and quickly reversible effect. Cangrelor has been studied in a ...
Afzal Sohaib Sm S Imperial College - - 2014
The term "resynchronisation" indicates restoration of simultaneity, which by implication refers to ventricular timings (VV delay) rather than atrioventricular (AV) delay. However, while AV delay adjustment causes large haemodynamic effects, different laboratories have reported contradictory results concerning the strength of the effect of VV optimisation. 22 patients in sinus rhythm ...
Vincze Z - - 2014
We examined 416 patients with acute myocardial infarction. 249 patients had STEMI and 167 NSTEMI. 227 were men and 189 women. 142 men had STEMI and 85 men had NSTEMI. 107 women were diagnosed with STEMI and 82 with NSTEMI. 22.5% of patient with STEMI and 20.2% of patients with ...
Chang Ta-Yuan TY China Medical University, Taichung, - - 2014
Exposure to noise has been associated with cardiovascular disease, but the mechanism related to cardiac activity is unknown. This repeated-measure study aimed to investigate effects of occupational noise exposure on 24-hour ambulatory cardiac parameters among aviation industry workers. We recruited 75 volunteers in an aircraft-manufacturing industrial cohort in 2009. Individual ...
Oni-Orisan Akinyemi A Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, - - 2014
Cardiovascular disease, including acute myocardial infarction (AMI), is the leading cause of morbidity and mortality globally, despite well-established treatments. The discovery and development of novel therapeutics that prevent the progression of devastating consequences following AMI are thus important in reducing the global burden of this devastating disease. Scientific evidence for ...
Hoogeveen Ellen K EK Department of Internal Medicine and Nephrology, Jeroen Bosch Hospital, Den Bosch, the Netherlands - - 2014
heart failure is a major risk factor for cardiovascular mortality, for which n-3 fatty acids may have beneficial effects. We examined the effect of marine eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and plant-derived alpha-linolenic acid (ALA) on N-Terminal-pro Brain Natriuretic Peptide (NT-proBNP), a biomarker of heart failure. we randomly ...
Kuehn Andreas A Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum - - 2014
Background:Coronary flow reserve (CFR) is reduced in patients with transposition of the great arteries (TGA) after the arterial switch operation (ASO). Dissection of the great arteries and coronary reimplantation may result in sympathetic denervation, with a negative effect on myocardial perfusion.Methods and Results:18 patients with TGA participated in the study; 9 had ...
Burashnikov Alexander A Masonic Medical Research Laboratory, Utica, - - 2014
-There is a critical need for safer and more effective pharmacological management of atrial fibrillation (AF) in the setting of heart failure (HF). -This study investigates the electrophysiological, anti- and pro-arrhythmic effects of a clinically-relevant concentration of ranolazine (5 µM) in coronary-perfused right atrial and left ventricular preparations isolated from ...
Momiyama Yukihiko Y Department of Cardiology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan. Electronic address: - - 2014
Apelin is an endogenous ligand for the orphan G protein-coupled receptor (APJ receptor). Apelin is predominantly expressed in endocardial and vascular endothelial cells, while APJ receptor is localized to endothelial and smooth muscle cells, and cardiomyocytes. Apelin has recently attracted much attention due to its promotive effects on angiogenesis and ...
Wei Bo B State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: - - 2014
The protective effect of sodium tanshinone IIA sulfonate (STS) pretreatment against experimental myocardial ischemia/reperfusion (I/R) has been demonstrated previously, however its therapeutic effects and mechanism of action still remain unclear. The objective of this study was to investigate the therapeutic time window and potential mechanism of STS action on myocardial ...
Schade Anja A Klinik für Kardiologie II (Interventionelle Elektrophysiologie), Herz-und Gefäßklinik Bad Neustadt, Salzburger Leite 1, 97616, Bad Neustadt a.d. Saale, Germany, - - 2014
Catheter ablation is an effective treatment for ventricular tachycardia (VT) in structural heart disease to reduce VT recurrence and implantable cardioverter defibrillator shocks.Current guidelines recommend ablation in patients with recurrent or incessant VT. In patients with left ventricular assist device (LVAD), VTs may be well tolerated hemodynamically and catheter ablation ...
Grossini Elena E E Grossini, Facoltà di Medicina e Chirurgi, Università del Piemonte Orientale, Novara, 28100, Italy - - 2014
Adiponectin, the most abundant adipokine released by adipose tissue, appears to play an important role in the regulation of vascular endothelial and cardiac function. To date however, the physiological effects of human monomeric adiponectin on the coronary vasculature and myocardial systo-diastolic function, as well as on parasympathetic/sympathetic involvement and nitric ...
Zhang Zheng Z Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi`an, 710032, - - 2014
5-Diphosphoinositol pentakisphosphate (IP7), formed by a family of inositol hexakisphosphate kinases (IP6Ks), has been demonstrated to be a physiologic inhibitor of Akt. IP6K inhibition may increase Akt activation in mesenchymal stem cells (MSCs), resulting in enhanced cardiac protective effect after transplantation. The aim of this study was to investigate the ...
Gonca Ersöz E Biology Department, Faculty of Art and Sciences, Bülent Ecevit University, İncivez, Zonguldak, Turkey - - 2014
Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid with anti-inflammatory activity mediated by enhancing adenosine signaling. As the adenosine A1 receptor activation confers protection against ischemia/reperfusion (I/R)-induced ventricular arrhythmias, we hypothesized that CBD may have antiarrhythmic effect through the activation of adenosine A1 receptor. Cannabidiol has recently been shown to suppress ischemia-induced ...
Rognoni Andrea A Coronary Care Unit and Catheterization Laboratory, "Maggiore della Carità" Hospital, Corso Mazzini 18, 28100 Novara, - - 2014
Intra-aortic balloon counterpulsation is the most widely used form of mechanical hemodynamic support in the setting of cardiogenic shock due to ST-segment elevation myocardial infarction (STEMI). Intra-aortic balloon pump (IABP) is also strongly recommended (class 1b) in the current European guidelines for treatment of STEMI. The evidence of a possible ...
1 2 3 4 5 6 7 8 9 10 >