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Wloch Agata A Department of Obstetrics and Gynecology, Medical University of Silesia, Katowice, - - 2014
To investigate the difference in forces developed by atrial and ventricular myocardium during contraction in human embryos using a novel method. A cross-sectional study of 115 pregnancies examined at 6-10 weeks of gestation. Ventricular inflow and outflow velocities were obtained by Doppler echocardiography and the relative force development was evaluated ...
Chen Jing J Department of Biotechnology, Institute of Life Sciences, Fujian Normal University, Fuzhou, Fujian, - - 2014
The cardiac toxicity of zebrafish embryos in response to the lethal dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been well characterized. However dioxin contamination levels in nature are usually lower and sublethal TCDD toxicity is less investigated. We found that for the 72 hours post fertilization (hpf) zebrafish embryos, the non-lethal doses ...
Riehle Christian C Fraternal Order of Eagles Diabetes Research Center, Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of - - 2014
Autophagy is a conserved cellular process that plays an important role in cardiovascular homeostasis. Basal levels of autophagy are required for the maintenance of organellar quality control. Autophagy is dynamically regulated in the heart in the fasting to re-feeding transition. Insulin signaling plays an important role in the regulation of ...
Diman Nata Y NY Center for Molecular Cardiology, Weill Cornell Medical - - 2014
Rationale: Holt-Oram syndrome (HOS) is an autosomal dominant heart-hand syndrome caused by mutations in the TBX5 gene. Overexpression of Tbx5 in the chick proepicardial organ (PEO) impaired coronary blood vessel formation. However, the potential activity of Tbx5 in the epicardium itself, and Tbx5's role in mammalian coronary vasculogenesis, remains largely ...
Rognoni Andrea A Coronary Care Unit and Catheterization Laboratory, A.O.U. Maggiore della Carità, Novara, - - 2014
Cardiovascular disease, in particular acute coronary syndromes (ACS), is still one of the leading causes of death in industrialized countries. ACS including ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI) and unstable angina pectoris (UA) are associated with lower mortality if diagnosed early. The diagnosis is based on clinical symptoms, ...
Oni-Orisan Akinyemi A From the *University of North Carolina at Chapel Hill, UNC Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Chapel Hill, NC; and †Advanced Heart Failure and Cardiac Transplantation, Research Scientist, Center for Health Services Research, Henry Ford Hospital, Detroit, - - 2014
Heart failure is becoming increasingly prevalent in the United States and is a significant cause of morbidity and mortality. Several therapies are currently available to treat this chronic illness; however, clinical response to these treatment options exhibit significant interpatient variation. It is now clearly understood that genetics is a key ...
Saxena Amit A Albert Einstein College of - - 2014
Regulatory T cells (Tregs) play a pivotal role in suppressing immune responses regulating behavior and gene expression in effector T cells, macrophages and dendritic cells. Tregs infiltrate the infarcted myocardium; however, their role the inflammatory and reparative response following myocardial infarction remains poorly understood. We used foxp3(EGFP) reporter mice to ...
Knecht Stephanie E SE Lexington VA Medical Center, Lexington, KY, - - 2014
Angiotensin inhibitors have been extensively evaluated in clinical trials and have demonstrated significant reductions in morbidity and mortality following myocardial infarction and stroke, as well as in patients with heart failure or who are at risk of cardiovascular disease. Further, both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) ...
Zverev A A AA Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia, - - 2014
We studied the effect of neuropeptide Y in concentrations of 10(-10)-10(-6) M on myocardial contractility of rats at the age of 7, 21, and 100 days. Studying the isometric contraction of myocardial strips showed that neuropeptide Y decreases the force of myocardial contraction in 7-day-old rat pups. Exogenous neuropeptide Y ...
Panza Julio A JA Westchester Medical Center and New York Medical College, Valhalla, New York. Electronic address: - - 2014
Patients with ischemic left ventricular dysfunction have higher operative risk with coronary artery bypass graft surgery (CABG). However, those whose early risk is surpassed by subsequent survival benefit have not been identified. This study sought to examine the impact of anatomic variables associated with poor prognosis on the effect of CABG ...
Lerman Bruce B BB Division of Cardiology, Department of Medicine, Cornell University Medical Center, New York, - - 2014
There is no universally accepted method by which to diagnose clinical ventricular tachycardia (VT) due to cAMP-mediated triggered activity. Based on cellular and clinical data, adenosine termination of VT is thought to be consistent with a diagnosis of triggered activity. However, a major gap in evidence mitigates the validity of ...
Akpek Mahmut M Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey - - 2014
We evaluated the acute effect of intracoronary administration of tirofiban on no-reflow phenomenon in patients with ST-segment elevated myocardial infarction undergoing primary percutaneous coronary intervention. Consecutive patients (n = 162) were randomized into 2 groups based on whether intracoronary tirofiban was administered. After the administration of intracoronary tirofiban, thrombolysis in ...
Miller Mark R MR *University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, - - 2014
Air pollution has been estimated to be responsible for several millions of deaths worldwide per year, the majority of which have been attributed to cardiovascular causes. The particulate matter in air pollution has been shown impair vascular function, increase blood pressure, promote thrombosis and impair fibrinolysis, accelerate the development of ...
Zhang Qian Q State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, PR - - 2014
Statins protect mesenchymal stem cells (MSCs) against the harsh microenvironment and improve the efficacy of MSC transplantation after acute myocardial infarction (AMI); however, the mechanism remains uncertain. Furthermore, the transdifferentiation potential of MSCs in the post-infarct heart remains highly controversial. The RhoA/Rho-associated coiled-coil-forming kinase (ROCK) pathway participates in many aspects ...
de Carvalho Eduardo Elias Vieira EE Cardiology Division, Internal Medicine Department, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, São Paulo, - - 2014
Primary microvascular angina (PMA) is a common clinical condition associated to negative impact on quality of life (QOL) and reduced physical capacity. This study aimed at evaluating the effects of aerobic physical training (APT) on myocardial perfusion, physical capacity, and QOL in patients with PMA. We investigated 12 patients (53.8 ± 9.7 years ...
Kharche Sanjay R SR College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, EX4 4QF, UK Biological Physics Group, School of Physics and Astronomy, University of Manchester, Manchester M13 9PL, - - 2014
Atrial anti-arrhythmic effects of β-adrenoceptor antagonists (β-blockers) may involve both a suppression of pro-arrhythmic effects of catecholamines, and an adaptational electrophysiological response to chronic β-blocker use; so-called 'pharmacological remodelling'. In human atrium, such remodelling decreases the transient outward (Ito) and inward rectifier (IK1) K(+) currents, and increases the cellular action ...
Kang Jeehoon J Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital National Research Laboratory for Stem Cell Niche, Seoul National University College of Medicine Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, - - 2014
From our previous clinical trials, intracoronary infusion of granulocyte-colony stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cells ((mob)PBMCs) proved to be effective in improving myocardial contractility and reducing infarct volume in acute myocardial infarction. We tested the effect of priming (mob)PBMCs with Erythropoietin (EPO) to augment its therapeutic efficacy. (mob)PBMCs were ...
Walfridsson Håkan H Department of Cardiology, University Hospital, Linköping, - - 2014
We aimed at examining the acetylcholine-dependent inward-rectifier current (IKAch) as a target for the management of atrial fibrillation (AF). The investigative agents AZD2927 and A7071 concentration-dependently blocked IKACh in vitro with minimal off-target activity. In anaesthetized dogs (n = 17) subjected to 8 weeks of rapid atrial pacing (RAP), the ...
Sodian Ralf R Department of Cardiac Surgery, Ludwig-Maximilians-Universität München, Munich, Germany - - 2014
Atrioventricular (AV) disruption is a rare but fatal complication after prosthetic mitral valve replacement. Surgical management is controversial and ranges from epicardial tissue sealing to open repair using autologous or xenogenic patch techniques to autotransplantation of the heart. We report the successful repair of an AV disruption Type I using ...
Gu Yongwei Y Department of Cardiology, The Fourth Affiliated Hospital of Nantong University (The First People's Hospital of Yancheng), Yancheng, Jiangsu 224006, P.R. - - 2014
Artemisinin has been demonstrated to exert beneficial effects on ventricular remodeling. The present study investigated whether artemisinin was able to decrease the ventricular fibrillation threshold (VFT) in rats following myocardial infarction (MI) and aimed to determine the possible underlying mechanisms. The rats were subjected to surgery to induce MI by ...
Shang Ruiping - - 2014
L-carnitine supplementation has been associated with a significant reduction in all-cause mortality, ventricular arrhythmia, and angina in the setting of acute myocardial infarction (MI). However, on account of strict homeostatic regulation of plasma L-carnitine concentrations, higher doses of L-carnitine supplementation may not provide additional therapeutic benefits. This study aims to ...
Izumi-Nakaseko Hiroko H Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16, Omori-nishi Ota-ku, Tokyo 143-8540, - - 2014
An inversion of electro-mechanical coupling; namely, mechanical relaxation which precedes electrical repolarization, has been proposed as a surrogate marker to predict the occurrence of drug-induced arrhythmias. The present study was designed to qualitatively and quantitatively clarify the effects of rapidly activating delayed rectifier K(+) current (IKr)-selective blockade by E-4031 on ...
McGarvey Jeremy R JR University of - - 2014
A treatment target for progressive LV remodeling prevention following myocardial infarction (MI) is to affect structural changes directly within the MI region. One approach is through targeted injection of biocomposite materials, such as calcium hydroxyapatite (CHAM), into the MI region. In this study, the effects of CHAM injections upon key ...
Yamakawa Kentaro K Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, - - 2014
Vagal nerve stimulation (VNS) has been proposed as a cardioprotective intervention. However, regional ventricular electrophysiological effects of VNS are not well characterized. The purpose of this study was to evaluate effects of right and left VNS on electrophysiological properties of the ventricles and hemodynamic parameters. In Yorkshire pigs, a 56-electrode ...
Dohi Kaoru K Department of Cardiology and Nephrology, Mie University Graduate School of - - 2014
Fluid management is of paramount importance in the treatment strategy of heart failure (HF), but the therapeutic efficacy of loop diuretic-based treatment for HF patients is limited by insufficient response and adverse effects. Clinical data establishing the efficacy and safety of tolvaptan, a selective oral vasopressin V2 receptor antagonist that ...
Zhao Shijie S Department of Geriatric Cardiology, First Affiliated Hospital, China Medical University, Shenyang, - - 2014
Adjunctive therapy with intracoronary nitroprusside (NTP) in primary percutaneous coronary intervention (PPCI) had controversial benefits in patients with ST segment elevation myocardial infarction (STEMI). To evaluate the effect of intracoronary NTP on no reflow phenomenon (NR) and clinical outcomes in STEMI patients undergoing PPCI. We searched the following databases without ...
Xie Juan J The Trauma Emergency & Critical Care Medicine Center, the Fifth People's Hospital of Shanghai, Fudan - - 2014
Background: Air pollution can be a contributing cause to the development and exacerbation of coronary heart disease (CHD), but there is little knowledge about the acute effects of air pollution on different clinical subtypes of CHD.Methods: We conducted a time-series study to investigate the association of air pollution (particulate matter ...
Tagliamonte Ercole E Cardiology Division, "Umberto I" Hospital, Nocera Inferiore, - - 2014
Ranolazine reduces the Na-dependent calcium overload via inhibition of the late sodium current, improving diastolic tone and oxygen handling during myocardial ischemia. In patients with angina, evidence of myocardial ischemia, but no obstructive coronary artery disease (CAD), abnormal coronary autoregulation plays a key role. Transthoracic Doppler-derived coronary flow reserve (CFR) ...
Khori Vahid V Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, - - 2014
Simvastatin (SV) leads to reduction of ventricular rhythm during atrial fibrillation on rabbit atrioventricular (AV) nodes. The aim of our study was (i) to determine the frequency-dependent effects of SV in a functional model, and (ii) to assess the effects of SV to suppress experimental atrioventricular nodal reentrant tachycardia (AVNRT). ...
Gullo Caio Eduardo - - 2014
Heart Failure (HF) is a progressive and fatal disorder, which ranks among the major public health problems in Brazil and worldwide. However, survival for patients who developed the syndrome after myocardial infarction (MI) enhanced significantly, as a result of an improvement of pharmacological therapies. A medical breakthrough was the discovery ...
Dlesk Anton A 5th Department of Internal Medicine, Medical Faculty of Commenius University and University Hospital, RuÅžinovská 6, 826 06, Bratislava, Slovakia, - - 2014
The aim of the study was to evaluate the effect of growth hormone (GH) replacement therapy on the morphological and functional changes in the left ventricle (LV) in patients with GH deficiency (GHD). Patients with adult-onset GHD were treated with GH. Transthoracic echocardiography was performed at baseline and after 6 ...
Hodcroft Christopher J CJ Department of Acute Medicine, Royal Glamorgan Hospital, Llantrisant, United - - 2014
The use of cannabis is not usually regarded as a risk factor for acute coronary syndrome. However, several cases of myocardial infarction (MI) associated with cannabis use have been reported in the scientific literature. The etiology of this phenomenon is not known. To present a case of cannabis-associated MI in ...
Cuspidi Cesare C aDepartment of Health Science, University of Milano-Bicocca bIstituto Auxologico Italiano cDepartment of Clinical Sciences and Community Health, University of Milano and Fondazione Policlinico di Milano, Milan, Italy dUniversity Clinical Hospital Centre 'Dragisa Misovic', Belgrade, Serbia eIstituto di Ricerche a Carattere Scientifico Multimedica, Sesto San Giovanni, Milan, - - 2014
Left ventricular (LV) changes associated with obesity, including LV hypertrophy and impaired LV function, have been shown to be reverted by bariatric surgery. Little is known about the effects of bariatric procedures on right ventricle (RV). We analyzed the literature in order to provide a comprehensive information on RV structural ...
Kisvari G G University of Szeged, Department of Pharmacology and Pharmacotherapy, Szeged, - - 2014
In a previous study we have shown that a single dose of simvastatin markedly reduced the severity of ventricular arrhythmias that resulted from a 25 min ischaemia and reperfusion (I/R) in anaesthetized dogs. This protection seems to involve the generation of nitric oxide (NO) via the activation of NO synthase ...
Bharti S S All India Institute of Medical Sciences, New Delhi, - - 2014
We established previously that Crocus sativus and its carotenoid crocin protects the myocardium via augmenting the endogenous antioxidant defense system. Since, heat shock protein70 (Hsp70) actively participates in shielding the cell from oxidative stress, programmed or necrotic cell deaths; we hypothesized that Hsp70 might be the actual mediator behind the ...
Garcia-Prieto J J National Centre for Cardiovascular Research (CNIC), Atherothrombosis, Epidemiology and Imaging Department, Madrid, - - 2014
Beta3-adrenergic receptor (b3AR) stimulation reduces myocardial ischemia/reperfusion injury (IRI) in vivo. The aim of this study was to assess whether this effect is exerted directly in the cardiomyocytes and to investigate the role of the mPTP in this protection. Adult isolated and HL-1 cardiomyocytes were subjected to hypoxia/reoxygenation (H/R) in ...
Rodriguez-Sinovas A A Institut de Recerca Hospitals Vall d'Hebron, Lab. Cardiologia Experimental, Barcelona, - - 2014
Ventricular arrhythmias are a common clinical manifestation in patients with acute myocardial infarction submitted to coronary revascularizaton. Reperfusion arrhythmias have been associated with successful myocardial reperfusion during thrombolytic therapy, but they have been also suggested to be a marker of large infarct size and worse prognosis. Ischemic postconditioning (PostC) has ...
Babba M M Coventry University, Biomolecular and Sport Sciences, Coventry, United - - 2014
Recent studies have emphasised an important role for Artemisinin as an effective and potent anticancer cancer drug, with significantly less adverse effects in comparison to traditional chemotherapeutic agents. Most of the widely used cancer treatments are limited in use due to their dose dependent cardiotoxicity. Artemisinin has been found to ...
Muntean D D University of Medicine Victor Babes, Pathophysiology, Timisoara, - - 2014
Whether cardioprotective strategies are still effective in elderly is a matter of debate. The present study was purported to assess the persistence of the protective effects of pharmacological agents targeting mitochondria in old Sprague-Dawley rats. Methods. To this aim isolated hearts from old (20-24 mo) and adult (4-6 mo) animals ...
Khaliulin I I University of Bristol, Bristol, United - - 2014
We have recently discovered that consecutive treatment of heart with isoproterenol and adenosine (Iso/Ade treatment), with a high dose of Iso (200 nM), confers strong protection against ischemia and reperfusion injury. Here we investigate whether this effect can be achieved at clinically relevant dose of Iso and identify the mechanism ...
Szucs G G Cardiovascular Research Group, Department of Biochemistry, University Of Szeged, Szeged, - - 2014
We have previously reported that chronic oral treatment with the HMG-CoA reductase inhibitor lovastatin shows cardioprotection but interacts with the cardioprotective effect of postconditioning and that farnesol, a key intermediate of the mevalonate pathway, is cardioprotective possibly via enhancement of protein geranylgeranylation. Here we studied the interaction of the HMG-CoA ...
Leon E E Cardiocentro "Ernesto Che Guevara", Santa Clara, - - 2014
To determine the synergistic effect of glycemia and leukocyte count by leukoglycemic index (LGI) on prognosis in patients with myocardial infarction with ST segment elevation (STEMI). Methods: A prospective longitudinal study of 233 patients diagnosed with STEMI who were admitted to a secondary hospital was performed. Clinical data and cardiac ...
Goshovska Y Y Bogomoletz Institute of Physiology, Kiev, - - 2014
Hydrogen sulfide (H2S) is endogenously generated from L-cysteine by cystathionine-gamma-lyase (CSE). H2S donors demonstrate cardioprotective properties, however, role of endogenous H2S is not revealed. We hypothesized that exogenous L-cysteine may stimulate H2S synthesis and mediate cardioprotection. At the same time L-cysteine might be engaged in gluthatione production. Thus, the aim ...
Duicu O M OM Department of Pathophysiology "Victor Babes" University of Medicine and Pharmacy, Timisoara, - - 2014
Modulation of mitochondrial function in the settings of ischemia/reperfusion (I/R) injury represents a major therapeutic target of pharmacological agents able to reduce the cell death at reperfusion. The aim of this study was to compare the effects of acute administration of magnesium orotate (MO), MgCl2, orotic acid (OA) with those ...
Markava I I Republican Scientific and Practical Centre of Cardiology, Minsk, - - 2014
The objective was to find out the value of the markers that reflect the pathophysiology of destabilization of ischemic heart disease in risk stratification and access the effectiveness of the secondary prevention. This prospective study included 180 hospitalized patients (M/F=120/60, 57±3) with UA and low to intermediate Grace score. End-points ...
Estévez-Loureiro Rodrigo R Rodrigo Estévez-Loureiro, Armando Pérez de Prado, Carlos Cuellas, Norberto Alonso-Orcajo, Maria López-Benito, Felipe Fernández-Vázquez, Division of Cardiology, Complejo Asistencial Universitario de León (CAULE), 24071 Leon, - - 2014
Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction (STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the ...
Schmidt Michael Rahbek MR Michael Rahbek Schmidt, Kasper Pryds, Hans Erik Bøtker, Department of Cardiology, Aarhus University Hospital Skejby, 8200 Aarhus N, - - 2014
Myocardial infarction is a major cause of death and disability worldwide and myocardial infarct size is a major determinant of prognosis. Early and successful restoration of myocardial reperfusion following an ischemic event is the most effective strategy to reduce final infarct size and improve clinical outcome, but reperfusion may induce ...
Zhu Pengju P Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766 Jingshi Road, 250014, Jinan, - - 2014
Radiofrequency catheter ablation (RFCA) is an effective therapy for atrial fibrillation (AF). This study was designed to investigate the effects of RFCA on left ventricular (LV) structure and function in AF patients. A systematic literature search in MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed to identify ...
Chevalier Julie J Chair of Health Systems, ESSEC Business School, Cergy-Pontoise, France. Electronic address: - - 2014
Atrial fibrillation is the main cause of stroke, but the risk can be reduced, usually with vitamin K antagonists (VKAs) such as warfarin. The RE-LY atrial fibrillation study demonstrated that the rates of stroke and systemic embolism with dabigatran (an oral direct thrombin inhibitor) were similar to or lower than ...
Liu Chao C Heart Center, The First Hospital of Hebei Medical University. Electronic address: - - 2014
Diuretic resistance in heart failure is defined as a state in which diuretic response is diminished or lost before the therapeutic goal of relief from congestion has been reached. Diuretic resistance is very common and is associated with poor outcomes. Over the past decade, several new drugs and devices targeting ...
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