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Riehle Christian C Fraternal Order of Eagles Diabetes Research Center, Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of - - 2014
Autophagy is a conserved cellular process that plays an important role in cardiovascular homeostasis. Basal levels of autophagy are required for the maintenance of organellar quality control. Autophagy is dynamically regulated in the heart in the fasting to re-feeding transition. Insulin signaling plays an important role in the regulation of ...
Diman Nata Y NY Center for Molecular Cardiology, Weill Cornell Medical - - 2014
Rationale: Holt-Oram syndrome (HOS) is an autosomal dominant heart-hand syndrome caused by mutations in the TBX5 gene. Overexpression of Tbx5 in the chick proepicardial organ (PEO) impaired coronary blood vessel formation. However, the potential activity of Tbx5 in the epicardium itself, and Tbx5's role in mammalian coronary vasculogenesis, remains largely ...
Oni-Orisan Akinyemi A From the *University of North Carolina at Chapel Hill, UNC Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Chapel Hill, NC; and †Advanced Heart Failure and Cardiac Transplantation, Research Scientist, Center for Health Services Research, Henry Ford Hospital, Detroit, - - 2014
Heart failure is becoming increasingly prevalent in the United States and is a significant cause of morbidity and mortality. Several therapies are currently available to treat this chronic illness; however, clinical response to these treatment options exhibit significant interpatient variation. It is now clearly understood that genetics is a key ...
Rognoni Andrea A Coronary Care Unit and Catheterization Laboratory, A.O.U. Maggiore della Carità, Novara, - - 2014
Cardiovascular disease, in particular acute coronary syndromes (ACS), is still one of the leading causes of death in industrialized countries. ACS including ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI) and unstable angina pectoris (UA) are associated with lower mortality if diagnosed early. The diagnosis is based on clinical symptoms, ...
Saxena Amit A Albert Einstein College of - - 2014
Regulatory T cells (Tregs) play a pivotal role in suppressing immune responses regulating behavior and gene expression in effector T cells, macrophages and dendritic cells. Tregs infiltrate the infarcted myocardium; however, their role the inflammatory and reparative response following myocardial infarction remains poorly understood. We used foxp3(EGFP) reporter mice to ...
Knecht Stephanie E SE Lexington VA Medical Center, Lexington, KY, - - 2014
Angiotensin inhibitors have been extensively evaluated in clinical trials and have demonstrated significant reductions in morbidity and mortality following myocardial infarction and stroke, as well as in patients with heart failure or who are at risk of cardiovascular disease. Further, both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) ...
Panza Julio A JA Westchester Medical Center and New York Medical College, Valhalla, New York. Electronic address: - - 2014
Patients with ischemic left ventricular dysfunction have higher operative risk with coronary artery bypass graft surgery (CABG). However, those whose early risk is surpassed by subsequent survival benefit have not been identified. This study sought to examine the impact of anatomic variables associated with poor prognosis on the effect of CABG ...
Zverev A A AA Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia, - - 2014
We studied the effect of neuropeptide Y in concentrations of 10(-10)-10(-6) M on myocardial contractility of rats at the age of 7, 21, and 100 days. Studying the isometric contraction of myocardial strips showed that neuropeptide Y decreases the force of myocardial contraction in 7-day-old rat pups. Exogenous neuropeptide Y ...
Lerman Bruce B BB Division of Cardiology, Department of Medicine, Cornell University Medical Center, New York, - - 2014
There is no universally accepted method by which to diagnose clinical ventricular tachycardia (VT) due to cAMP-mediated triggered activity. Based on cellular and clinical data, adenosine termination of VT is thought to be consistent with a diagnosis of triggered activity. However, a major gap in evidence mitigates the validity of ...
Akpek Mahmut M Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey - - 2014
We evaluated the acute effect of intracoronary administration of tirofiban on no-reflow phenomenon in patients with ST-segment elevated myocardial infarction undergoing primary percutaneous coronary intervention. Consecutive patients (n = 162) were randomized into 2 groups based on whether intracoronary tirofiban was administered. After the administration of intracoronary tirofiban, thrombolysis in ...
de Carvalho Eduardo Elias Vieira EE Cardiology Division, Internal Medicine Department, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, São Paulo, - - 2014
Primary microvascular angina (PMA) is a common clinical condition associated to negative impact on quality of life (QOL) and reduced physical capacity. This study aimed at evaluating the effects of aerobic physical training (APT) on myocardial perfusion, physical capacity, and QOL in patients with PMA. We investigated 12 patients (53.8 ± 9.7 years ...
Kharche Sanjay R SR College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, EX4 4QF, UK Biological Physics Group, School of Physics and Astronomy, University of Manchester, Manchester M13 9PL, - - 2014
Atrial anti-arrhythmic effects of β-adrenoceptor antagonists (β-blockers) may involve both a suppression of pro-arrhythmic effects of catecholamines, and an adaptational electrophysiological response to chronic β-blocker use; so-called 'pharmacological remodelling'. In human atrium, such remodelling decreases the transient outward (Ito) and inward rectifier (IK1) K(+) currents, and increases the cellular action ...
Miller Mark R MR *University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, - - 2014
Air pollution has been estimated to be responsible for several millions of deaths worldwide per year, the majority of which have been attributed to cardiovascular causes. The particulate matter in air pollution has been shown impair vascular function, increase blood pressure, promote thrombosis and impair fibrinolysis, accelerate the development of ...
Zhang Qian Q State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, PR - - 2014
Statins protect mesenchymal stem cells (MSCs) against the harsh microenvironment and improve the efficacy of MSC transplantation after acute myocardial infarction (AMI); however, the mechanism remains uncertain. Furthermore, the transdifferentiation potential of MSCs in the post-infarct heart remains highly controversial. The RhoA/Rho-associated coiled-coil-forming kinase (ROCK) pathway participates in many aspects ...
Walfridsson Håkan H Department of Cardiology, University Hospital, Linköping, - - 2014
We aimed at examining the acetylcholine-dependent inward-rectifier current (IKAch) as a target for the management of atrial fibrillation (AF). The investigative agents AZD2927 and A7071 concentration-dependently blocked IKACh in vitro with minimal off-target activity. In anaesthetized dogs (n = 17) subjected to 8 weeks of rapid atrial pacing (RAP), the ...
Kang Jeehoon J Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital National Research Laboratory for Stem Cell Niche, Seoul National University College of Medicine Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, - - 2014
From our previous clinical trials, intracoronary infusion of granulocyte-colony stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cells ((mob)PBMCs) proved to be effective in improving myocardial contractility and reducing infarct volume in acute myocardial infarction. We tested the effect of priming (mob)PBMCs with Erythropoietin (EPO) to augment its therapeutic efficacy. (mob)PBMCs were ...
Sodian Ralf R Department of Cardiac Surgery, Ludwig-Maximilians-Universität München, Munich, Germany - - 2014
Atrioventricular (AV) disruption is a rare but fatal complication after prosthetic mitral valve replacement. Surgical management is controversial and ranges from epicardial tissue sealing to open repair using autologous or xenogenic patch techniques to autotransplantation of the heart. We report the successful repair of an AV disruption Type I using ...
Gu Yongwei Y Department of Cardiology, The Fourth Affiliated Hospital of Nantong University (The First People's Hospital of Yancheng), Yancheng, Jiangsu 224006, P.R. - - 2014
Artemisinin has been demonstrated to exert beneficial effects on ventricular remodeling. The present study investigated whether artemisinin was able to decrease the ventricular fibrillation threshold (VFT) in rats following myocardial infarction (MI) and aimed to determine the possible underlying mechanisms. The rats were subjected to surgery to induce MI by ...
Shang Ruiping - - 2014
L-carnitine supplementation has been associated with a significant reduction in all-cause mortality, ventricular arrhythmia, and angina in the setting of acute myocardial infarction (MI). However, on account of strict homeostatic regulation of plasma L-carnitine concentrations, higher doses of L-carnitine supplementation may not provide additional therapeutic benefits. This study aims to ...
Izumi-Nakaseko Hiroko H Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16, Omori-nishi Ota-ku, Tokyo 143-8540, - - 2014
An inversion of electro-mechanical coupling; namely, mechanical relaxation which precedes electrical repolarization, has been proposed as a surrogate marker to predict the occurrence of drug-induced arrhythmias. The present study was designed to qualitatively and quantitatively clarify the effects of rapidly activating delayed rectifier K(+) current (IKr)-selective blockade by E-4031 on ...
McGarvey Jeremy R JR University of - - 2014
A treatment target for progressive LV remodeling prevention following myocardial infarction (MI) is to affect structural changes directly within the MI region. One approach is through targeted injection of biocomposite materials, such as calcium hydroxyapatite (CHAM), into the MI region. In this study, the effects of CHAM injections upon key ...
Yamakawa Kentaro K Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, - - 2014
Vagal nerve stimulation (VNS) has been proposed as a cardioprotective intervention. However, regional ventricular electrophysiological effects of VNS are not well characterized. The purpose of this study was to evaluate effects of right and left VNS on electrophysiological properties of the ventricles and hemodynamic parameters. In Yorkshire pigs, a 56-electrode ...
Dohi Kaoru K Department of Cardiology and Nephrology, Mie University Graduate School of - - 2014
Fluid management is of paramount importance in the treatment strategy of heart failure (HF), but the therapeutic efficacy of loop diuretic-based treatment for HF patients is limited by insufficient response and adverse effects. Clinical data establishing the efficacy and safety of tolvaptan, a selective oral vasopressin V2 receptor antagonist that ...
Zhao Shijie S Department of Geriatric Cardiology, First Affiliated Hospital, China Medical University, Shenyang, - - 2014
Adjunctive therapy with intracoronary nitroprusside (NTP) in primary percutaneous coronary intervention (PPCI) had controversial benefits in patients with ST segment elevation myocardial infarction (STEMI). To evaluate the effect of intracoronary NTP on no reflow phenomenon (NR) and clinical outcomes in STEMI patients undergoing PPCI. We searched the following databases without ...
Xie Juan J The Trauma Emergency & Critical Care Medicine Center, the Fifth People's Hospital of Shanghai, Fudan - - 2014
Background: Air pollution can be a contributing cause to the development and exacerbation of coronary heart disease (CHD), but there is little knowledge about the acute effects of air pollution on different clinical subtypes of CHD.Methods: We conducted a time-series study to investigate the association of air pollution (particulate matter ...
Tagliamonte Ercole E Cardiology Division, "Umberto I" Hospital, Nocera Inferiore, - - 2014
Ranolazine reduces the Na-dependent calcium overload via inhibition of the late sodium current, improving diastolic tone and oxygen handling during myocardial ischemia. In patients with angina, evidence of myocardial ischemia, but no obstructive coronary artery disease (CAD), abnormal coronary autoregulation plays a key role. Transthoracic Doppler-derived coronary flow reserve (CFR) ...
Khori Vahid V Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, - - 2014
Simvastatin (SV) leads to reduction of ventricular rhythm during atrial fibrillation on rabbit atrioventricular (AV) nodes. The aim of our study was (i) to determine the frequency-dependent effects of SV in a functional model, and (ii) to assess the effects of SV to suppress experimental atrioventricular nodal reentrant tachycardia (AVNRT). ...
Gullo Caio Eduardo - - 2014
Heart Failure (HF) is a progressive and fatal disorder, which ranks among the major public health problems in Brazil and worldwide. However, survival for patients who developed the syndrome after myocardial infarction (MI) enhanced significantly, as a result of an improvement of pharmacological therapies. A medical breakthrough was the discovery ...
Dlesk Anton A 5th Department of Internal Medicine, Medical Faculty of Commenius University and University Hospital, Ružinovská 6, 826 06, Bratislava, Slovakia, - - 2014
The aim of the study was to evaluate the effect of growth hormone (GH) replacement therapy on the morphological and functional changes in the left ventricle (LV) in patients with GH deficiency (GHD). Patients with adult-onset GHD were treated with GH. Transthoracic echocardiography was performed at baseline and after 6 ...
Hodcroft Christopher J CJ Department of Acute Medicine, Royal Glamorgan Hospital, Llantrisant, United - - 2014
The use of cannabis is not usually regarded as a risk factor for acute coronary syndrome. However, several cases of myocardial infarction (MI) associated with cannabis use have been reported in the scientific literature. The etiology of this phenomenon is not known. To present a case of cannabis-associated MI in ...
Cuspidi Cesare C aDepartment of Health Science, University of Milano-Bicocca bIstituto Auxologico Italiano cDepartment of Clinical Sciences and Community Health, University of Milano and Fondazione Policlinico di Milano, Milan, Italy dUniversity Clinical Hospital Centre 'Dragisa Misovic', Belgrade, Serbia eIstituto di Ricerche a Carattere Scientifico Multimedica, Sesto San Giovanni, Milan, - - 2014
Left ventricular (LV) changes associated with obesity, including LV hypertrophy and impaired LV function, have been shown to be reverted by bariatric surgery. Little is known about the effects of bariatric procedures on right ventricle (RV). We analyzed the literature in order to provide a comprehensive information on RV structural ...
Zhu Pengju P Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766 Jingshi Road, 250014, Jinan, - - 2014
Radiofrequency catheter ablation (RFCA) is an effective therapy for atrial fibrillation (AF). This study was designed to investigate the effects of RFCA on left ventricular (LV) structure and function in AF patients. A systematic literature search in MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed to identify ...
Estévez-Loureiro Rodrigo R Rodrigo Estévez-Loureiro, Armando Pérez de Prado, Carlos Cuellas, Norberto Alonso-Orcajo, Maria López-Benito, Felipe Fernández-Vázquez, Division of Cardiology, Complejo Asistencial Universitario de León (CAULE), 24071 Leon, - - 2014
Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction (STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the ...
Schmidt Michael Rahbek MR Michael Rahbek Schmidt, Kasper Pryds, Hans Erik Bøtker, Department of Cardiology, Aarhus University Hospital Skejby, 8200 Aarhus N, - - 2014
Myocardial infarction is a major cause of death and disability worldwide and myocardial infarct size is a major determinant of prognosis. Early and successful restoration of myocardial reperfusion following an ischemic event is the most effective strategy to reduce final infarct size and improve clinical outcome, but reperfusion may induce ...
Chevalier Julie J Chair of Health Systems, ESSEC Business School, Cergy-Pontoise, France. Electronic address: - - 2014
Atrial fibrillation is the main cause of stroke, but the risk can be reduced, usually with vitamin K antagonists (VKAs) such as warfarin. The RE-LY atrial fibrillation study demonstrated that the rates of stroke and systemic embolism with dabigatran (an oral direct thrombin inhibitor) were similar to or lower than ...
Liu Chao C Heart Center, The First Hospital of Hebei Medical University. Electronic address: - - 2014
Diuretic resistance in heart failure is defined as a state in which diuretic response is diminished or lost before the therapeutic goal of relief from congestion has been reached. Diuretic resistance is very common and is associated with poor outcomes. Over the past decade, several new drugs and devices targeting ...
Valgimigli Marco M Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands. Electronic address: - - 2014
The therapeutic potential of vorapaxar in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention (PCI) is unknown. This prespecified analysis of a postrandomization subgroup evaluated the effects of vorapaxar compared with placebo among Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) participants undergoing ...
Priester Tiffany T Cardiology Division, University of Utah, Salt Lake City, UT, - - 2014
Obesity is associated with elevated coronary artery calcium (CAC), a marker of coronary atherosclerosis that is strongly predictive of cardiovascular events. We evaluated the effects of marked weight loss achieved through Roux-en-Y gastric bypass surgery (GBS) on CAC scores. We performed echocardiography and computed tomography of the heart in 149 ...
Vaidya Anil - - 2014
Delayed diagnosis and treatment of Acute Myocardial Infarction (AMI) has a major adverse impact on prognosis in terms of both morbidity and mortality. Since conventional cardiac Troponin assays have a low sensitivity for diagnosing AMI in the first hours after myocardial necrosis, high-sensitive assays have been developed. The aim of ...
Ho Yi-Jin - - 2014
Caffeic acid phenethyl ester (CAPE) has been shown to protect the heart against ischemia/reperfusion (I/R) injury by various mechanisms including its antioxidant effect. In this study, we evaluated the protective effects of a CAPE analog with more structural stability in plasma, caffeic acid phenethyl amide (CAPA), on I/R injury in ...
Hansen Jan J Department of Biomedicine-Pharmacology, Aarhus University, University Park 1240, DK-8000, Aarhus C, - - 2014
The gut hormone glucagon-like peptide-1 (GLP-1) is an insulinotropic incretin with significant cardiovascular impact. Two classes of medication, GLP-1 analogues and DPP-4 inhibitors, have been developed that circumvent the rapid degradation of GLP-1 by the enzyme dipeptidyl peptidase-4 (DPP-4), both enhance the incretin effect and were developed for the treatment ...
Zhang Yanmin Y Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK; Heart Centre, Northwest Women's and Children's Hospital, Xi'an, 710003, P.R - - 2014
To test a hypothesis attributing arrhythmia in Brugada Syndrome to right ventricular (RV) outflow tract (RVOT) conduction abnormalities arising from Nav 1.5 insufficiency and fibrotic change. Arrhythmic properties of Langendorff-perfused Scn5a+/- and wild-type mouse hearts were correlated with ventricular effective refractory periods (VERPs), multi-electrode array (MEA) measurements of action potential ...
Masoumi Nafiseh N Department of Bioengineering, The Pennsylvania State University, University Park, PA, - - 2014
Cyclic flexure and stretch are essential to the function of semilunar heart valves and have demonstrated utility in mechanically conditioning tissue-engineered heart valves. In this study, a cyclic stretch and flexure bioreactor was designed and tested in the context of the bioresorbable elastomer poly(glycerol sebacate). Solid poly(glycerol sebacate) membranes were ...
Milojevic Ai A Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, - - 2014
To inform potential pathophysiological mechanisms of air pollution effects on cardiovascular disease (CVD), we investigated short-term associations between ambient air pollution and a range of cardiovascular events from three national databases in England and Wales. Using a time-stratified case-crossover design, over 400 000 myocardial infarction (MI) events from the Myocardial Ischaemia ...
Yoshino Takuya T T Yoshino, Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, - - 2014
Although persistent excessive actions of aldosterone have unfavorable effects on the cardiovascular system, primarily via mineralocorticoid receptor-dependent pathways, the pathophysiological significance of aldosterone cascade activation in heart diseases has not yet been fully clarified. We herein examined the effects of short-term aldosterone stimulation at a physiological dose on the cardiac ...
Marino Marcello M University of Pavia, Pavia, - - 2014
Platelet inhibition is the main goal of ancillary pharmacologic therapy during percutaneous coronary interventions (PCI). Thienopyridines and ticagrelor are oral drugs developed for this purpose. Cangrelor is an intravenous, non-thienopyridine antagonist of the P2Y12 receptor with a rapid, potent, predictable, and quickly reversible effect. Cangrelor has been studied in a ...
Vincze Z - - 2014
We examined 416 patients with acute myocardial infarction. 249 patients had STEMI and 167 NSTEMI. 227 were men and 189 women. 142 men had STEMI and 85 men had NSTEMI. 107 women were diagnosed with STEMI and 82 with NSTEMI. 22.5% of patient with STEMI and 20.2% of patients with ...
Chang Ta-Yuan TY China Medical University, Taichung, - - 2014
Exposure to noise has been associated with cardiovascular disease, but the mechanism related to cardiac activity is unknown. This repeated-measure study aimed to investigate effects of occupational noise exposure on 24-hour ambulatory cardiac parameters among aviation industry workers. We recruited 75 volunteers in an aircraft-manufacturing industrial cohort in 2009. Individual ...
Oni-Orisan Akinyemi A Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, - - 2014
Cardiovascular disease, including acute myocardial infarction (AMI), is the leading cause of morbidity and mortality globally, despite well-established treatments. The discovery and development of novel therapeutics that prevent the progression of devastating consequences following AMI are thus important in reducing the global burden of this devastating disease. Scientific evidence for ...
Hoogeveen Ellen K EK Department of Internal Medicine and Nephrology, Jeroen Bosch Hospital, Den Bosch, the Netherlands - - 2014
heart failure is a major risk factor for cardiovascular mortality, for which n-3 fatty acids may have beneficial effects. We examined the effect of marine eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and plant-derived alpha-linolenic acid (ALA) on N-Terminal-pro Brain Natriuretic Peptide (NT-proBNP), a biomarker of heart failure. we randomly ...
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