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Results 301 - 350 of 2074
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Wenk Jonathan F JF Department of Mechanical Engineering, University of Kentucky, Lexington, Kentucky, - - 2013
The Acorn CorCap Cardiac Support Device (CSD; Acorn Cardiovascular Inc, St. Paul, MN) is a woven polyester jacket that is placed around the heart and designed to reverse the progressive remodeling associated with dilated cardiomyopathy. However, the effects of the Acorn CSD on myofiber stress and ventricular function remain unknown. ...
Han Jin - - 2013
BACKGROUND: The aim of this study was to investigate the cardioprotective effect of fimasartan, a newly developed angiotensin II receptor type I blocker (ARB), against myocardial ischemia/reperfusion (I/R) injury and to identify the mechanism by which it reduces mitochondrial damage. METHODS: Fimasartan was administered intravenously to Sprague-Dawley rats (3mg/kg), cardiomyocytes ...
Eyre T - - 2013
Anaemia is common in patients with congestive heart failure, and has an adverse effect on prognosis. This article discusses the advances in understanding of the pathophysiology of the anaemia, the treatment options including transfusion, and highlights areas in need of further development.
Riccioni Graziano - - 2013
Evaluation of: Tardif JC, Ponikowski P, Kahan T; on behalf of the ASSOCIATE investigators. Effects of ivabradine in patients with stable angina receiving beta-blockers according to baseline heart rate: an analysis of the ASSOCIATE study. Int. J. Cardiol. pii:S0167-5273(12)01385-X (2012). Chronic stable angina pectoris is the most common manifestation of ...
Kiani Amjad - - 2013
Some pharmacological preconditioning approaches are utilized as an effective adjunct to myocardial protection, particularly following cardiac procedures. The current study addressed the potential clinical implications and protective effects of isoflurane as an anesthetic most applicable on postoperative myocardial function measured by cardiac biomarkers. 46 patients were included in the study. ...
Dmitriev Yu V - - 2013
The cardioprotective effects of necroptosis inhibitors necrostatin-1 and necrostatin-5 were studied on the isolated heart model in rats. Intraperitoneal injection of necrostatin-1 (1.65 mg/kg) or necrostatin-5 (2.46 mg/kg) 60 min before reperfusion of the isolated heart reduced the infarction zone caused by 30-min global ischemia and 120-min reperfusion. Intracoronary injection ...
Cassuto James - - 2013
BACKGROUND: A paradoxical inverse relationship between body mass index, morbidity and mortality in patients with ischemic heart disease has been noted; but the underlying mechanisms remain unclear. Given that coronary resistance arteries are the primary regulators of myocardial blood flow, we examined the effects of obesity and medication on dilator ...
Liu Haiyan - - 2013
Numerous studies revealed that the effective rate of β-blockers for hypertension treatment is about 50∼60%, which was mainly due to interindividual difference in drug response, especially for β-blocker metoprolol. Previous studies have demonstrated that cytochrome P450 2D6 (CYP2D6) and β1-adrenergic receptor (ADRB1) gene polymorphisms could affect metoprolol antihypertensive efficacy. However, ...
Cervigón Raquel - - 2013
During atrial fibrillation (AF), multiple wandering propagation wavelets at high rates drift around both atria under controversial hierarchical models. Antiarrhythmic drugs modify the cardiac ionic currents supporting the fibrillation process within the atria, and can alter AF propagation dynamics and even terminate the arrhythmia. However, some other drugs, theoretically nonantiarrhythmic, ...
Ali Ali - - 2013
The severe teratogenic side effects of thalidomide led to its well-publicized withdrawal in the 1970s, but as it is cautiously being reintroduced into clinical use, new adverse effects are being described. A 65-year-old male with multiple myeloma received chemotherapy which included cyclophosphamide, thalidomide and dexamethasone. Whilst on this treatment he ...
Ingram Thomas E - - 2013
OBJECTIVES: To assess the potential benefits of inorganic nitrite in two clinical models: stress-induced myocardial ischemia and whole arm ischemia/reperfusion (IR). BACKGROUND: Inorganic nitrite, traditionally considered a relatively inert metabolite of nitric oxide, may exert vasomodulatory and vasoprotective effects. Despite promising results from animal models, few have shown effectiveness in ...
George Robert S - - 2013
AIMS: Dilated cardiomyopathy (DCM) patients have abundant levels of norepinephrine secondary to failure of the norepinephrine transporter uptake mechanism. Little is known about the effects of an LV assist device (LVAD) on cardiac sympathetic innervations and norepinephrine transporter dysfunction. This study examines the effects of continuous-flow HeartMate II LVAD on ...
Pathak A - - 2013
WHAT IS KNOWN AND OBJECTIVE: Positive inotropic agents are frequently used in acute decompensated heart failure (ADHF) due to left ventricular systolic dysfunction. These agents are known to improve cardiac performance and peripheral perfusion in the short-term treatment. However, several preclinical and clinical studies emphasized detrimental effects of these drugs ...
Diez Emiliano R - - 2013
Reperfusion arrhythmias are currently attributed to ionic imbalance and oxidative stress. Tamoxifen is a potent antioxidant that also modulates some ionic transport pathways. In this work we tried to correlate the electrophysiologic effects of 1, 2 and 5 µM tamoxifen with the incidence and severity of arrhythmias appearing on reperfusion ...
Gilbert Richard E - - 2013
The prevention of cardiovascular disease is among our highest priorities in managing patients with diabetes. The concerns that arose from the association between rosiglitazone use and the incidence of myocardial infarction have led drug regulation authorities to mandate evidence of cardiovascular safety before a new anti-hyperglycaemic agent can be approved. ...
Ahmet Ismayil - - 2013
The cardioprotective properties of erythropoietin (EPO) in pre-clinical studies are well documented, but erythropoietic and prothrombotic properties of EPO preclude its use in chronic heart failure (CHF). We tested the effect of long-term treatment with a small peptide sequence within the EPO molecule, Helix B surface peptide (HBSP), that possess ...
Pedrinelli Roberto - - 2013
Systemic hypertension is highly prevalent in stable coronary artery disease, a pervasive comorbidity complicating the diagnostic performance and interpretation of non-invasive provocative tests in chest pain patients because of the ischaemic signals generated, despite normal or near normal coronary arteries, by hearts structurally readapted by long-term exposure to raised systemic ...
Neckář Jan - - 2013
The purpose of the present study was to assess the impact of brief daily reoxygenation during adaptation to chronic continuous hypoxia (CCH) on protective cardiac phenotype. Adult male Wistar rats were kept at CCH (10% oxygen) for 5, 15 or 30 days; a subgroup of animals was exposed to room ...
Shuvy Mony - - 2013
Oxygen supplementation is a standard treatment for all patients who present with acute coronary syndrome, regardless of oxygen saturation levels. Most of the data regarding the function of oxygen in myocardial infarction is based on a limited number of basic and clinical studies. We performed a systematic literature review that ...
Czifra Arpád - - 2013
BACKGROUND: Renal replacement therapy may have a favorable effect on diastolic left ventricular function, but it is not clear whether hemodiafiltration is superior to hemodialysis in this field. Nitric oxide (NO) and asymmetric dimethylarginine (ADMA) may play a role in the changes of intracardiac hemodynamics, but it is not clear ...
Wong Cheuk-Kit - - 2013
Recurrent ischemic events after an acute coronary syndrome (ACS) are frequent, despite current antiplatelet therapies and revascularization. Warfarin reduces recurrent ischemia but increases bleeding. Warfarin is difficult to administer with the proportion of time achieving therapeutic international normalized ratios varying within and among individuals. The newer oral anticoagulants have predictable ...
Bonita Raphael - - 2013
Cancer chemotherapy has improved over the years with the advent of newer agents, including more targeted chemotherapeutic drugs, resulting in better patient survival. However, with continued use and patient exposure to these drugs, important cardiovascular adverse effects are becoming realized, such as left ventricular dysfunction and heart failure, myocardial ischemia, ...
Winterfield Jeffrey R - - 2013
PURPOSE OF REVIEW: Drug-refractory ventricular tachycardia in the setting of structural heart disease results in frequent implantable cardioverter defibrillator therapies and an increased risk of heart failure. Management requires catheter ablation procedures for effective suppression of the arrhythmia. RECENT FINDINGS: Imaging and electroanatomic mapping technologies provide new insights into the ...
Chaichana Thanapong - - 2013
PURPOSE: Coronary plaque has been shown to directly affect the blood parameters, however, haemodynamic variations based on the plaque configuration has not been studied. In this study we investigate the haemodynamic effects of various types of plaques in the left coronary bifurcation. METHODS: Eight types of plaque configurations were simulated ...
Costache Irina Iuliana II Department of Cardiology, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa" - - - 2013
Discovered in 1961 by Tondeur and Binon, two Belgian chemists, amiodarone was widely used, especially in Europe, initially as an antianginal agent, and later as an antiarrhythmic one (following the experiments conducted at the University of Oxford by Dr. Bramah Singh). Thus, the role of amiodarone was reconsidered, becoming, together ...
Hermida Nerea - - 2013
AIMS: The metabolic syndrome (MS) leads to myocardial fibrosis (MF) and diastolic dysfunction. Statins have proven beneficial effects in MS, but their impact on cardiac remodelling is uncertain. We examined the effects and mechanisms of chronic statin treatment on cardiac remodelling, e.g. fibrosis and diastolic properties. METHODS AND RESULTS: We ...
Mueller Martin - - 2013
Tissue loss after myocardial ischemia with reperfusion (MI/R) is in part conveyed by neutrophil recruitment to post-ischemic myocardium. Strategies to prevent reperfusion injury would help to limit myocardial damage. The receptor for activated complement factor 5 (C5aR) plays a prominent role in inflammation. We examine the effects of C5aR-deficiency on ...
Fröhlich Georg M GM The Heart Hospital, University College London Hospitals, 16-18 Westmoreland Street, W1G 8PH, London, - - 2013
Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), timely myocardial reperfusion using either thrombolytic therapy or primary percutaneous coronary intervention (PPCI) is the most effective therapy for limiting myocardial infarct (MI) size, preserving ...
Liu Mi-Hua - - 2013
Angiogenic stimulation is a promising new strategy for treating patients with arteriosclerotic coronary artery disease. This strategy aims to ameliorate cardiac function by improving myocardial perfusion and lowering the risk of myocardial infarction. However, angiogenesis may contribute to the growth of atherosclerotic lesions. Atherogenesis is also a potential side effect ...
Waldman M - - 2013
Tetrahydrocannabinol (THC), the major psychoactive component of marijuana, is a cannabinoid agonist that exerts its effects by activating at least two specific receptors (CB1 and CB2) that belong to the seven transmembrane G-protein coupled receptor (GPCR) family. Both CB1 and CB2 mRNA and proteins are present in the heart. THC ...
Germanakis Ioannis - - 2013
The present study focuses on the short term effects of repeated low level administration of turinabol and methanabol on cardiac function in young rabbits (4 months-old). The experimental scheme consisted of two oral administration periods, lasting one month each, interrupted by one-month wash-out period. Serial echocardiographic evaluation at the end ...
Leonardi Sergio - - 2013
AimsThe TRA·CER trial compared vorapaxar, a novel platelet protease-activated receptor (PAR)-1 antagonist, with placebo in 12 944 patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACS). In this analysis, we explored the effect of vorapaxar on myocardial infarction (MI).Methods and resultsA blinded, independent central endpoint adjudication committee prospectively defined ...
Zhao Man-man MM Department of Pediatrics, Peking University First Hospital, Beijing 100034, - - 2013
To explore the mechanisms underlying the protection by SO2 preconditioning against rat myocardial ischemia/reperfusion (I/R) injury. Male Wistar rats underwent 30-min left coronary artery ligation followed by 120-min reperfusion. An SO2 donor (1 μmol/kg) was intravenously injected 10 min before the ischemia, while LY294002 (0.3 mg/kg) was intravenously injected 30 ...
Axelsson B - - 2013
BACKGROUND: Although inotropic stimulation is considered harmful in the presence of myocardial ischaemia, both calcium sensitisers and phosphodiesterase inhibitors may offer cardioprotection. We hypothesise that these cardioprotective effects are related to an acute alteration of myocardial metabolism. We studied in vivo effects of milrinone and levosimendan on calcium overload and ...
Minoura Yoshino Y Masonic Medical Research Laboratory, Utica, New York 13501, - - 2013
Wenxin Keli (WK), a Chinese herb extract, is reported to be effective in the treatment of atrial and ventricular cardiac arrhythmias. Recent studies suggest that WK inhibits the transient potassium outward current (I(to)). To examine the effectiveness of WK, alone and in combination with quinidine, to suppress arrhythmogenesis in an ...
Molenaar Peter - - 2013
BACKGROUND AND PURPOSE: Phosphodiesterases PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle are unknown. We investigated whether the PDE3-selective inhibitor cilostamide (0.3-1μM) or PDE4 inhibitor rolipram (1-10μM) modified the positive inotropic and lusitropic effects of catecholamines in human failing ...
Shah Sachil - - 2013
Pharmacologic stress testing uses vasodilators to provide objective evidence of myocardial ischemia. Adenosine and dipyridamole are nonselective adenosine receptor agonists that have been associated with myocardial infarction (MI) during intravenous infusion. Mechanisms postulated for this effect include coronary steal, transmural steal, global hypotension, and direct vasoconstriction. Regadenoson, a direct A2A ...
Khatua Tarak Nath - - 2013
Garlic is widely recognized for its immense therapeutic potential. Garlic has been shown to exert its beneficial effects against a wide spectrum of diseases, including cancer, diabetes, and microbial infections, as well as immunological and cardiovascular disorders. Most of the research on garlic has indicated that garlic and its active ...
Alghatrif Majd - - 2013
Obesity is associated with increased diastolic stiffness and myocardial steatosis and dysfunction. The impact of aging on the protective effects of caloric restriction (CR) is not clear. We studied 2-month (younger) and 6-7-month (older)-old ob/ob mice and age-matched C57BL/6J controls (WT). Ob/ob mice were assigned to diet ad libitum or ...
Tabrizchi Reza - - 2013
Evaluation of: Zuckerman IH, Yin X, Rattinger GB et al. Effect of exposure to evidence-based pharmacotherapy on outcomes after acute myocardial infarction in older adults. J. Am. Geriatr. Soc. 60(10), 1854-1861 (2012). The number of myocardial infarctions (MIs) in population remains high and this event is a significant predictor of mortality. ...
Hwang Dae Seong - - 2013
Purpose: The aim of this study was to demonstrate the early effects of statin treatment on plaque composition according to plaque stability on Intravascular Ultrasound- Virtual Histology at 6 months after a coronary event. Previous trials have demonstrated that lipid lowering therapy with statins decreases plaque volume and increases plaque ...
Calhoun McKenzie - - 2013
Evaluation of: Bangalore S, Steg PG, Deedwania P et al. β-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA 308(13), 1340-1349 (2012). The number of myocardial infarctions (MIs) in population remains high and this event is a significant predictor of mortality. Information in the literature ...
Yabluchanskiy Andriy A San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center, San Antonio, TX 78245, - - 2013
Myocardial infarction (MI) remains a major cause of morbidity and mortality worldwide. Rapid advances in the treatment of acute MI have significantly improved short-term outcomes in patients, due in large part to successes in preventing myocardial cell death and limiting infarct area during the time of ischemia and subsequent reperfusion. ...
Zeymer Uwe U Klinikum der Stadt Ludwigshafen GmbH, Bremserstraße 79, 67063, Ludwigshafen, Germany, - - 2013
The purpose of this article is to summarize the current knowledge about treatment with oral platelet inhibitors in patients with acute coronary syndrome (ACS). Antiplatelet therapy has been shown to improve the prognosis of patients with ACS with ST segment elevation myocardial infarction (STEMI) and non-ST segment elevation ACS (NSTE-ACS). ...
Bai Hongyuan - - 2013
Abstract Objectives: To evaluate the effectiveness and safety of Chinese herbal medicine (CHM) as an adjunctive treatment for patients with dilated cardiomyopathy (DCM) and heart failure. Design: Studies on biomedical treatment plus CHM versus biomedical treatment alone in treating patients with DCM and heart failure were retrieved from PubMed and ...
Testai Lara - - 2013
Flavonoids are important components of 'functional foods', with beneficial effects on the cardiovascular function, mainly due to their antioxidant activity. Many flavonoids exert antihypertensive, anti-atherosclerotic and antiplatelet activity and positive effects against endothelial dysfunction. Recent evidence indicates that they exert cardioprotective effects against myocardial ischaemia/reperfusion (I/R) injury. The aim of ...
De Servi Stefano - - 2013
A series of trials have shown that bivalirudin, a direct thrombin inhibitor that does not require the cofactor antithrombin III to be effective, is a reasonable alternative to unfractionated heparin (UFH) alone or associated with glycoprotein IIb/IIIa antagonists (GPI) in patients undergoing percutaneous coronary interventions (PCI). Particularly in patients with ...
Sontag David P - - 2013
The anti-cancer drug doxorubicin is associated with an increased risk of cardiac damage and dysfunction, which can be acute as well as chronic. Fibroblast growth factor 2 (FGF-2) provides cardioprotection from ischemia-reperfusion injury but its effects on doxorubicin-induced damage are not known. We investigated the acute effects of doxorubicin administered ...
Tsuji Yukiomi Y Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Hufelandstr 55, 45122, Essen, - - 2013
The implantable cardioverter-defibrillator significantly improves survival in patients with malignant ventricular arrhythmias but does not target the underlying pathological substrate responsible for arrhythmic events. A significant proportion of defibrillator recipients experience multiple ventricular tachycardia/fibrillation episodes over a short period of time, termed electrical storm (ES). The current therapeutic strategy for ...
He Hua - - 2013
ABSTRACT: This study aimed to investigate the effects of salvianolic acid A (Sal A) on the time course of plasma and tissues dimethylarginine levels after myocardial infarction (MI) induced by left coronary artery ligation. The rats were assigned to 4 groups: Sham, MI, MI treated with Sal A (1 or ...
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